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TNR Gene

protein-coding   GIFtS: 66
GCID: GC01M175291

Tenascin R

  See TNR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4.2

Aliases
Tenascin R1 2     tenascin-R2
janusin1 2     Janusin3
restrictin1 2     Restrictin3
TN-R2 3     

External Ids:    HGNC: 119531   Entrez Gene: 71432   Ensembl: ENSG000001161477   OMIM: 6019955   UniProtKB: Q927523   
ORGUL members:    fRNAdb10:FR225370 FR105653 FR304635 FR347368 FR185812      
H-InvDB12:HIT000325769    
NCBI13:Y13359    
NONCODE14:n326321 n338375 n326320    
RNAdb15:HIV1373 EVF4245 EVF4247 EVF4252 EVF4250 see all 6    

Export aliases for TNR gene to outside databases

Previous GC identifers: GC01M172816 GC01M170720 GC01M171872 GC01M172531 GC01M172023 GC01M173558 GC01M146518


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNR Gene:
This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is
restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion
and modulation of sodium channel function. It is a constituent of perineuronal nets. (provided by RefSeq, Aug
2013)

GeneCards Summary for TNR Gene:
TNR (tenascin R) is a protein-coding gene. Diseases associated with TNR include osteochondritis dissecans, and familial osteochondritis dissecans. An important paralog of this gene is TNXB.

UniProtKB/Swiss-Prot: TENR_HUMAN, Q92752
Function: Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix
components. These interactions can influence cellular behavior by either evoking a stable adhesion and
differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits
RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and
cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and
differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth.
Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes
of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and
mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate
structure may modulate the adhesive properties of TNR over the course of development and during synapse
maintenance (By similarity)

Gene Wiki entry for TNR (Tenascin-R) Gene

fRNAdb sequence ontologies for TNR - the ORGUL cluster for this gene includes several descriptions:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for TNR

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNR gene promoter:
         LHX3b/Lhx3b   Sox5   STAT1   RP58   ATF-2   Olf-1   HEN1   CRE-BP1   LHX3a/Lhx3a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNR promoter sequence
   Search Chromatin IP Primers for TNR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q24

TNR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M175291:  view genomic region     (about GC identifiers)

Start:
175,284,330 bp from pter      End:
175,712,906 bp from pter
Size:
428,577 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TNR

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TENR_HUMAN, Q92752 (See protein sequence)
Recommended Name: Tenascin-R precursor  
Size: 1358 amino acids; 149562 Da
Subunit: Forms oligomers. Interacts with CNTN1, TNC, and FN1. Interacts with BCAN and ACAN in a calcium-dependent
manner. Interacts with SCN2B, PTPRZ1, and CSPG3 (By similarity)
Secondary accessions: C9J563 Q15568 Q5R3G0
Alternative splicing: 2 isoforms:  Q92752-1   Q92752-2   

Explore the universe of human proteins at neXtProt for TNR: NX_Q92752

Explore proteomics data for TNR at MOPED

Post-translational modifications: 

  • Contains N-linked oligosaccharides, O-linked sialylated structures and O-linked chondroitin sulfate
    glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure (By similarity).
    O-glycosylated on Thr-36 or Thr-37 with a core 1 or possibly core 8 glycan1
  • Glycosylation2 at Thr36, Thr37, Asn55, Asn180, Asn198, Asn278, Asn392, Asn470, Asn581, Asn791,
                                 Asn874, Asn1036, Asn1046, Asn1261
  • Modification sites at PhosphoSitePlus

  • See TNR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003276.3  
    ENSEMBL proteins: 
     ENSP00000356646   ENSP00000403413   ENSP00000263525  
    Reactome Protein details: Q92752

    TNR Human Recombinant Protein Products:

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    Novus Biologicals TNR Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for TNR

     
    Search eBioscience for Proteins for TNR 

    TNR Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for TNR

    TNR Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TNR
    Cloud-Clone Corp. CLIAs for TNR
    Search eBioscience for ELISAs for TNR 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    FIBC: Fibrinogen C domain containing

    Selected InterPro protein domains (see all 7):
     IPR003961 Fibronectin_type3
     IPR013032 EGF-like_CS
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR002181 Fibrinogen_a/b/g_C_dom
     IPR013111 EGF_extracell

    Graphical View of Domain Structure for InterPro Entry Q92752

    ProtoNet protein and cluster: Q92752

    1 Blocks protein domain: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: TENR_HUMAN, Q92752
    Domain: The EGF-like domains mediate interaction with CNTN1. The fibronectin type-III domains 3-5 mediate
    interaction with BCAN. The fibronectin type-III domains 1-2 and 7-9 mediate interaction with SCN2B (By
    similarity)
    Similarity: Belongs to the tenascin family
    Similarity: Contains 5 EGF-like domains
    Similarity: Contains 1 fibrinogen C-terminal domain
    Similarity: Contains 9 fibronectin type-III domains


    Find genes that share domains with TNR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TENR_HUMAN, Q92752
    Function: Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix
    components. These interactions can influence cellular behavior by either evoking a stable adhesion and
    differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits
    RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and
    cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and
    differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth.
    Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes
    of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and
    mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate
    structure may modulate the adhesive properties of TNR over the course of development and during synapse
    maintenance (By similarity)

         Genatlas biochemistry entry for TNR:
    tenascin-R,extracellular neural recognition molecule,expressed in glia and some neuronal subtypes,including
    horizontal cells in retina,putative ortholog of mouse loop-tail,interacting with fibronectin-dependent cell
    attachment and interaction,inhibitor of CD3-mediated T cell interaction

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TNR           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tnr):
     nervous system  no phenotypic analysis 

    Find genes that share phenotypes with TNR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tnrtm1Msch for TNR

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNR
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNR

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TNR (see all 12):
    hsa-miR-3163 hsa-miR-205 hsa-miR-922 hsa-miR-7-2* hsa-miR-516b* hsa-miR-1279 hsa-miR-340 hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidTNR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TNR
    Predesigned siRNA for gene silencing in human, mouse, rat TNR

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for TNR
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    GenScript: all cDNA clones in your preferred vector: TNR (NM_005958)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNR

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    Browse ESI BIO Cell Lines and PureStem Progenitors for TNR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TENR_HUMAN, Q92752: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus4
    plasma membrane2
    cytosol1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with TNR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNR About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    ECM-receptor interaction0.31
    Focal Adhesion0.65
    2Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    3PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway
    4MicroRNAs in cancer
    MicroRNAs in cancer
    5ECM proteoglycans
    ECM proteoglycans


    Find genes that share SuperPaths with TNR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for TNR
        Cell adhesion Cell-matrix glycoconjugates

    1 BioSystems Pathway for TNR
        Focal Adhesion

    1 Reactome Pathway for TNR
        ECM proteoglycans


    4 Kegg Pathways  (Kegg details for TNR):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Array including TNR: 
              Neurogenesis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TNR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNR (Q927523 ENSP000002635254) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNTN1Q128603, ENSP000003256604I2D: score=1 STRING: ENSP00000325660
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    NFASCO948563, ENSP000003531544I2D: score=1 STRING: ENSP00000353154
    SIGLEC1Q9BZZ23, ENSP000003411414I2D: score=1 STRING: ENSP00000341141
    BCANQ96GW73, ENSP000003312104I2D: score=2 STRING: ENSP00000331210
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion NAS8940128
    GO:0007158neuron cell-cell adhesion IEA--
    GO:0007411axon guidance NAS8940128
    GO:0008306associative learning IEA--
    GO:0010977negative regulation of neuron projection development ----

    Find genes that share ontologies with TNR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNR (TENR)

    2 HMDB Compounds for TNR    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    SodiumSodium (see all 2)7440-23-5--

    6 Novoseek inferred chemical compound relationships for TNR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurocan 88.3 7 9507007 (2), 16899820 (2), 10483914 (1), 18696101 (1) (see all 5)
    chondroitin sulfate 38.9 1 18696101 (1)
    calcium 0 2 9507007 (1), 17537973 (1)
    tyrosine 0 1 17068968 (1)
    testosterone 0 3 7539301 (2), 8933378 (1)
    polysaccharide 0 3 10406848 (2), 17537973 (1)



    Find genes that share compounds with TNR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    5/6 fRNAdb Secondary structures (see all 6):


    REFSEQ mRNAs for TNR gene: 
    NM_003285.2  

    Unigene Cluster for TNR:

    Tenascin R
    Hs.659864  [show with all ESTs]
    Unigene Representative Sequence: NM_003285
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367674(uc009wwu.1 uc010pmz.1) ENST00000422274 ENST00000263525(uc001gkp.1)

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    hsa-miR-3163 hsa-miR-205 hsa-miR-922 hsa-miR-7-2* hsa-miR-516b* hsa-miR-1279 hsa-miR-340 hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidTNR 3' UTR sequence
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    Additional mRNA sequence: 

    AK295823.1 BC129830.1 X98085.1 Y13359.1 Z67996.1 

    2 DOTS entries:

    DT.406347  DT.91720346 

    Selected AceView cDNA sequences (see all 67):

    BF740231 CD244497 AI879057 BF934451 BF514861 BF055935 AW160530 BF929429 
    AW293883 BE223030 BG007389 BX645837 AV721679 AA975526 BP349158 BX115029 
    BX950894 AA931902 T09112 X98085 AI298431 BG914014 Z67996 BE222657 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAGGTTCT
    TNR Expression
    About this image


    TNR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
             Oligodendrocyte-like cells
     
     Spinal Cord (Nervous System)
             Oligodendrocyte-like cells
     
     Oligodendrocytes (Nervous System)
             Oligodendrocyte-like cells
    TNR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.659864

    UniProtKB/Swiss-Prot: TENR_HUMAN, Q92752
    Tissue specificity: Brain specific

        Pathway & Disease-focused RT2 Profiler PCR Array including TNR: 
              Neurogenesis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNR gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnr1 , 5 tenascin R1, 5 88.27(n)1
    93.23(a)1
      1 (69.03 cM)5
    219601  NM_022312.31  NP_071707.21 
     1597375105 
    chicken
    (Gallus gallus)
    Aves TNR1 tenascin R (restrictin, janusin) 75.66(n)
    75.46(a)
      396213  NM_205276.2  NP_990607.2 
    lizard
    (Anolis carolinensis)
    Reptilia TNR6
    tenascin R
    77(a)
    1 ↔ 1
    4(71897527-72045815)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX724236.12   -- 77.3(n)    BX724236.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY286489.12   -- 73.82(n)   369191  AY286489.1 


    ENSEMBL Gene Tree for TNR (if available)
    TreeFam Gene Tree for TNR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for TNR gene
    TNXB2  ANGPTL32  FGA2  TNN2  ANGPTL42  ANGPTL52  FN12  TNC2  
    11 SIMAP similar genes for TNR using alignment to 3 protein entries:     TENR_HUMAN (see all proteins):
    FCN3    ANGPTL2    FCN2    MFAP4    FIBCD1    FCN1
    ANGPTL7    TNN    FGL1    LFIRE1    TNXB

    Find genes that share paralogs with TNR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNR (see all 9205)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107984091,2
    C,F,A,Huntested1175590376(+) CATCTA/G/TTCTGC 1 -- int134EA NA NS WA CSA 2989
    rs557157611,2
    C--146550885(+) ATGAGCA/-ATCCT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs3748027821,2
    C--146565864(+) ttttt-/TT/   
       TTTTT
    GGTGA
    1 -- int11NA 2
    rs561896231,2
    C--146850428(+) TTTTT-/T/TT  
            
    GGAGA
    1 -- int11NA 2
    rs1894811471,2
    --175291450(+) TGGGAA/GCTAGA 1 -- ds50010--------
    rs1810226661,2
    --175291452(+) GGAACC/TAGATT 1 -- ds50010--------
    rs1431545371,2
    --175291489(+) CTCTGC/GGGTCT 1 -- ds50010--------
    rs1850525901,2
    --175291615(+) TGGCCA/CATTAT 1 -- ds50010--------
    rs1466789651,2
    C--175291720(+) ACCAGA/CCTGGA 1 -- ds50010--------
    rs1894276661,2
    --175291757(+) AAAAAA/GTAAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TNR (175284330 - 175534330 bp, first 250kb of TNR)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TNR (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670531CNV Deletion23128226
    esv2719640CNV Deletion23290073
    esv2719662CNV Deletion23290073
    esv1283541CNV Deletion17803354
    esv2719673CNV Deletion23290073
    esv1005191CNV Deletion20482838
    esv2719651CNV Deletion23290073
    esv2719629CNV Deletion23290073
    nsv3633CNV Insertion18451855
    nsv3644CNV Insertion18451855

    Human Gene Mutation Database (HGMD): TNR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNR
    DNA2.0 Custom Variant and Variant Library Synthesis for TNR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601995OMIM information: 115665 116600 121800 155600 211420 600975 605225 605606 606788 606852 606928 607317 607671 608446 608543 608553 608995 605008    
    2 diseases for TNR:    
    About MalaCards
    osteochondritis dissecans    familial osteochondritis dissecans

    1 disease from the University of Copenhagen DISEASES database for TNR:
    Ehlers-Danlos syndrome

    Find genes that share disorders with TNR           About GenesLikeMe

    2 Novoseek inferred disease relationships for TNR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 15615725 (1)
    multiple sclerosis 0 3 10417662 (2)

    Genetic Association Database (GAD): TNR
    Human Genome Epidemiology (HuGE) Navigator: TNR (17 documents)

    Export disorders for TNR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNR gene, integrated from 10 sources (see all 110):
    (articles sorted by number of sources associating them with TNR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human tenascin-R: complete primary structure, pre-mRNA alternative splicing and gene localization on chromosome 1q23-q24. (PubMed id 8626505)1, 2, 3, 9 Carnemolla B.... Zardi L. (J. Biol. Chem. 1996)
    2. Parallel genotyping of 10,204 single nucleotide polymorphisms to screen for susceptible genes for IgA nephropathy. (PubMed id 19890582)1, 4, 9 Woo K.T....Chan C.M. (Ann. Acad. Med. Singap. 2009)
    3. The human tenascin-R gene. (PubMed id 8940128)1, 3, 9 Leprini A....Zardi L. (J. Biol. Chem. 1996)
    4. Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study. (PubMed id 18521090)1, 4, 9 Lavedan C....Polymeropoulos M.H. (Mol. Psychiatry 2009)
    5. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    6. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Genetic contribution to all cancers: the first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour pathology. (PubMed id 18415014)1, 4 LubiA8ski J....Scott R. (Breast Cancer Res. Treat. 2009)
    9. Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia. (PubMed id 19573479)1, 4 Volpi S....Lavedan C. (J Clin Psychiatry 2009)
    10. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)1, 4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7143 HGNC: 11953 AceView: TNR Ensembl:ENSG00000116147 euGenes: HUgn7143
    ECgene: TNR Kegg: 7143 H-InvDB: TNR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNR gene:
    Search GeneIP for patents involving TNR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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