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TNPO3 Gene

protein-coding   GIFtS: 56
GCID: GC07M128594

Transportin 3

(Previous name: limb girdle muscular dystrophy 1F (autosomal dominant))
(Previous symbol: LGMD1F)
  See TNPO3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transportin 31 2     TRN-SR22
LGMD1F1 2     imp122
Limb Girdle Muscular Dystrophy 1F (Autosomal Dominant)1 2     transportin-32
Importin 121 2     transportin-SR2
IPO122 3     Imp123
TRN-SR2 3     Importin-123
TRNSR2 5     Transportin-SR3
MTR10A2     

External Ids:    HGNC: 171031   Entrez Gene: 235342   Ensembl: ENSG000000644197   OMIM: 6100325   UniProtKB: Q9Y5L03   

Export aliases for TNPO3 gene to outside databases

Previous GC identifers: GC07M128149 GC07M128148 GC07M128188 GC07M128382 GC07M122955


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNPO3 Gene:
The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the
splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection,
apparently through interaction with the HIV-1 capsid protein. Two transcript variants encoding different isoforms
as well as a noncoding transcript have been found for this gene.(provided by RefSeq, Jul 2010)

GeneCards Summary for TNPO3 Gene:
TNPO3 (transportin 3) is a protein-coding gene. Diseases associated with TNPO3 include limb-girdle muscular dystrophy type 1f, and primary biliary cirrhosis. GO annotations related to this gene include receptor activity. An important paralog of this gene is IPO13.

UniProtKB/Swiss-Prot: TNPO3_HUMAN, Q9Y5L0
Function: Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the
nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains

Gene Wiki entry for TNPO3 (Transportin-3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNPO3 gene promoter:
         SRF   ISGF-3   USF1   MAZR   AP-1   Pax-5   SRF (504 AA)   CREB   USF-1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): TNPO3 promoter sequence
   Search Chromatin IP Primers for TNPO3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNPO3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.1   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q32.2

TNPO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNPO3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M128594:  view genomic region     (about GC identifiers)

Start:
128,594,234 bp from pter      End:
128,695,227 bp from pter
Size:
100,994 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 127,977,977-128,078,965     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TNPO3_HUMAN, Q9Y5L0 (See protein sequence)
Recommended Name: Transportin-3  
Size: 923 amino acids; 104203 Da
Subunit: Interacts with phosphorylated SFRS1 and SFRS2. Interacts with NUP62 and RBM4
Sequence caution: Sequence=AAD38537.1; Type=Frameshift; Positions=920;
3 PDB 3D structures from and Proteopedia for TNPO3:
4C0O (3D)        4C0P (3D)        4C0Q (3D)    
Secondary accessions: A4D1K9 C9IZM0 Q6NUM1 Q96G71 Q96GU9 Q9Y3R2
Alternative splicing: 4 isoforms:  Q9Y5L0-2   Q9Y5L0-1   Q9Y5L0-3   Q9Y5L0-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNPO3: NX_Q9Y5L0

Explore proteomics data for TNPO3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys628
  • Modification sites at PhosphoSitePlus

  • See TNPO3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177957.2  NP_036602.1  

    ENSEMBL proteins: 
     ENSP00000265388   ENSP00000420089   ENSP00000418646   ENSP00000418267   ENSP00000376936  

    TNPO3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IPO: Importins

    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR013598 Exportin-1/Importin-b-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9Y5L0

    ProtoNet protein and cluster: Q9Y5L0

    1 Blocks protein domain: IPB013598 Exportin 1-like


    Find genes that share domains with TNPO3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNPO3_HUMAN, Q9Y5L0
    Function: Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the
    nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS10366588
    GO:0005488binding ----
    GO:0005515protein binding IPI12628928
         
    Find genes that share ontologies with TNPO3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNPO3:
     Decreased p24 protein expressi  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNPO3
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    miRTarBase miRNAs that target TNPO3:
    hsa-mir-34a-5p (MIRT025217), hsa-mir-423-3p (MIRT042607), hsa-mir-24-3p (MIRT030364), hsa-mir-30a-5p (MIRT028439), hsa-mir-149-5p (MIRT045648), hsa-mir-17-5p (MIRT050985), hsa-mir-375 (MIRT019682), hsa-mir-16-5p (MIRT031422), hsa-mir-15b-5p (MIRT046428)

    Block miRNA regulation of human, mouse, rat TNPO3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNPO3 (see all 55):
    hsa-miR-21* hsa-miR-642a hsa-miR-513a-5p hsa-miR-1224-3p hsa-miR-1260b hsa-miR-128 hsa-miR-30d hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidTNPO3 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNPO3_HUMAN, Q9Y5L0: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with TNPO3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TNPO3
    Interactions:

        Search GeneGlobe Interaction Network for TNPO3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNPO3 (Q9Y5L02, 3 ENSP000002653884) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMURF2Q9HAU42, 3MINT-61784 I2D: score=3 
    RANP628263, ENSP000003961274I2D: score=8 STRING: ENSP00000396127
    ATG3Q9NT623, ENSP000002832904I2D: score=4 STRING: ENSP00000283290
    BRF2Q9HAW03, ENSP000002206594I2D: score=2 STRING: ENSP00000220659
    C20orf24Q9BUV83, ENSP000003412134I2D: score=2 STRING: ENSP00000341213
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0035048splicing factor protein import into nucleus IDA12628928

    Find genes that share ontologies with TNPO3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNPO3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNPO3 gene (2 alternative transcripts): 
    NM_001191028.2  NM_012470.3  

    Unigene Cluster for TNPO3:

    Transportin 3
    Hs.193613  [show with all ESTs]
    Unigene Representative Sequence: NR_034053
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265388 ENST00000482320 ENST00000471234 ENST00000471166 ENST00000393245(uc010llx.2 uc003vom.2 uc003vol.2 uc010llz.2 uc010lly.2)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TNPO3 (see all 55):
    hsa-miR-21* hsa-miR-642a hsa-miR-513a-5p hsa-miR-1224-3p hsa-miR-1260b hsa-miR-128 hsa-miR-30d hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidTNPO3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): TNPO3 (NM_012470)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNPO3
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      QuantiTect SYBR Green Assays in human, mouse, rat TNPO3
      QuantiFast Probe-based Assays in human, mouse, rat TNPO3

    Additional mRNA sequence: 

    AF145029.1 AJ133769.1 AK001263.1 AK022910.1 AK097374.1 AK225999.1 AK312580.1 BC009221.2 
    BC009923.2 BC068530.1 NR_034053.2 

    18 DOTS entries:

    DT.317886  DT.100815262  DT.100815261  DT.97785380  DT.121092818  DT.121092830  DT.100725585  DT.100815264 
    DT.92437137  DT.100815260  DT.121092835  DT.100815268  DT.121092824  DT.100815259  DT.121092839  DT.95176189 
    DT.95351551  DT.100804596 

    Selected AceView cDNA sequences (see all 330):

    CD673286 AI421825 AA282050 BF448101 AW196671 BC009923 F09161 NM_012470 
    BP357116 AW295686 AI139764 BC009221 BU157351 AI206723 CB961105 AA777057 
    AU124595 CB045232 BM991178 BU684243 BM476104 BM826507 BM982588 AI739531 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TNPO3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                          -                                                                                                                                 
    SP2:                                                                                                                                                            
    SP3:                    -     -                                                                                                                                 
    SP4:                    -     -     -     -                                                                                                                     
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25
    SP1:                  
    SP2:        -         
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for TNPO3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNPO3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TNPO3 Expression
    About this image

    TNPO3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNPO3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.193613
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNPO3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TNPO3 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnpo31 , 5 transportin 31, 5 90.79(n)1
    99.35(a)1
      6 (12.36 cM)5
    3209381  NM_177296.41  NP_796270.21 
     295408275 
    chicken
    (Gallus gallus)
    Aves TNPO31 transportin 3 77.27(n)
    93.54(a)
      426277  XM_423940.4  XP_423940.4 
    lizard
    (Anolis carolinensis)
    Reptilia TNPO36
    transportin 3
    89(a)
    1 ↔ 1
    GL343993.1(18796-78866)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.295082 Xenopus laevis transcribed sequence with moderate similarity more 81.1(n)    48024036 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc554092 similar to transportin-SR 76.02(n)   394062  BC045332.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trn-SR1 Transportin-Serine/Arginine rich 50.62(n)
    43.12(a)
      33465  NM_134864.4  NP_608708.2 
    worm
    (Caenorhabditis elegans)
    Secernentea tsr-11 tsr-1 43.91(n)
    30.98(a)
      173601  NM_061878.4  NP_494279.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MTR10(YOR160W)4
    MTR101
    Nuclear import receptor, mediates the nuclear localization more4
    MTR101
    40.93(n)1
    27.96(a)1
      15(633839-636757)4
    8543311, 4  NP_014803.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G626001 AT5G62600 40.77(n)
    26.8(a)
      836381  NM_125655.3  NP_201066.2 
    rice
    (Oryza sativa)
    Liliopsida Os10g04778001 Os10g0477800 42.33(n)
    28.14(a)
      9270745  NM_001189279.1  NP_001176208.1 


    ENSEMBL Gene Tree for TNPO3 (if available)
    TreeFam Gene Tree for TNPO3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNPO3 gene
    IPO132  

    Find genes that share paralogs with TNPO3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for TNPO3
    PGOHUM00000243187 PGOHUM00000241501


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNPO3 (see all 1912)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58873991,2
    C--122964057(+) TTTTTT/-CCCCC 3 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs350615091,2
    C--123006540(+) CACTG-/T/TT  
            
    TTTTT
    3 -- int12NA CSA 4
    rs745714981,2
    C--123006551(+) TTTTTC/TCCTTT 3 -- int10--------
    rs350692561,2
    C--123031075(+) CTACT-/AAAAAA 3 -- int10--------
    rs732403111,2
    C--127984886(+) AAAAAA/TTTTTT 3 -- int10--------
    rs354303771,2
    C--127991537(+) ATGAA-/AC/AC 
     AC
    /CACA
    CACAC
    3 -- int10--------
    rs669191291,2
    C--127997615(-) TTTTC-/TTTTTTT 3 -- int12Minor allele frequency- TT:0.25NA 4
    rs102470031,2
    C,H--127997622(+) gaaaaA/Ggaaaa 3 -- int1 trp34Minor allele frequency- G:0.11NA 126
    rs1425229361,2
    C--128001397(+) TTTTC-/TTTTTTT 3 -- int10--------
    rs355522271,2
    C--128005830(+) TCCACT/-TTTTT 3 -- int11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for TNPO3 (128594234 - 128695227 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TNPO3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735137CNV Deletion23290073
    esv2670312CNV Deletion23128226
    nsv507416CNV Insertion20534489
    nsv831125CNV Loss17160897

    Human Gene Mutation Database (HGMD): TNPO3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNPO3
    DNA2.0 Custom Variant and Variant Library Synthesis for TNPO3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610032    OMIM disorders: --

    3 diseases for TNPO3:    
    About MalaCards
    limb-girdle muscular dystrophy type 1f    primary biliary cirrhosis    hiv-1


    Find genes that share disorders with TNPO3           About GenesLikeMe

    Genetic Association Database (GAD): TNPO3
    Human Genome Epidemiology (HuGE) Navigator: TNPO3 (6 documents)

    Export disorders for TNPO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNPO3 gene, integrated from 10 sources (see all 89):
    (articles sorted by number of sources associating them with TNPO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transportin-SR, a nuclear import receptor for SR proteins. (PubMed id 10366588)1, 2, 3, 9 Kataoka N.... Dreyfuss G. (J. Cell Biol. 1999)
    2. A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins. (PubMed id 10713112)1, 2, 3, 9 Lai M.-C.... Tarn W.-Y. (J. Biol. Chem. 2000)
    3. Transportin-SR2 mediates nuclear import of phosphorylated SR proteins. (PubMed id 11517331)1, 2, 9 Lai M.-C.... Tarn W.-Y. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    4. Association of a functional polymorphism in the IRF5 region with systemic sclerosis in a Japanese population. (PubMed id 19479858)1, 4, 9 Ito I....Tsuchiya N. (Arthritis Rheum. 2009)
    5. Next-generation sequencing identifies transportin 3 as the causative gene for LGMD1F. (PubMed id 23667635)1, 3 Torella A....Nigro V. (PLoS ONE 2013)
    6. Limb-girdle muscular dystrophy 1F is caused by a microdeletion in the transportin 3 gene. (PubMed id 23543484)1, 3 MeliA M.J....MartA- R. (Brain 2013)
    7. Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis. (PubMed id 21750679)1, 4 Allanore Y....Martinez M. (PLoS Genet. 2011)
    8. Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. (PubMed id 21779181)1, 4 Gorlova O....Martin J. (PLoS Genet. 2011)
    9. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. (PubMed id 21408207)1, 4 Chung S.A....Criswell L.A. (PLoS Genet. 2011)
    10. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PubMed id 21399635)1, 4 Mells G.F....Anderson C.A. (Nat. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23534 HGNC: 17103 AceView: TNPO3 Ensembl:ENSG00000064419 euGenes: HUgn23534
    ECgene: TNPO3 H-InvDB: TNPO3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNPO3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNPO3 gene:
    Search GeneIP for patents involving TNPO3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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