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TNPO2 Gene

protein-coding   GIFtS: 56
GCID: GC19M012810

Transportin 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transportin 21 2     Karyopherin Beta 2b1
Importin 31 2     IPO32
Karyopherin Beta-2b2 3     Karyopherin Beta 2b, Transportin2
KPNB2B2 5     Transportin 2 (Importin 3, Karyopherin Beta 2b)2
TRN22 5     transportin-22

External Ids:    HGNC: 199981   Entrez Gene: 300002   Ensembl: ENSG000001055767   OMIM: 6030025   UniProtKB: O147873   

Export aliases for TNPO2 gene to outside databases

Previous GC identifers: GC19M012672 GC19M012673 GC19M012674 GC19M012383


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TNPO2 Gene:
TNPO2 (transportin 2) is a protein-coding gene. GO annotations related to this gene include nuclear localization sequence binding and Ran GTPase binding. An important paralog of this gene is TNPO1.

UniProtKB/Swiss-Prot: TNPO2_HUMAN, O14787
Function: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for
nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate
complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently
translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the
NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the
nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be
conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
(By similarity)

Gene Wiki entry for TNPO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNPO2 gene promoter:
         Sp1   Pax-6   Nkx2-5   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNPO2 promoter sequence
   Search Chromatin IP Primers for TNPO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNPO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.13

TNPO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNPO2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M012810:  view genomic region     (about GC identifiers)

Start:
12,810,008 bp from pter      End:
12,834,825 bp from pter
Size:
24,818 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TNPO2_HUMAN, O14787 (See protein sequence)
Recommended Name: Transportin-2  
Size: 897 amino acids; 101388 Da
Secondary accessions: O14655 Q6IN77
Alternative splicing: 2 isoforms:  O14787-1   O14787-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNPO2: NX_O14787

Explore proteomics data for TNPO2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys71, Lys484, Lys862
  • Modification sites at PhosphoSitePlus

  • See TNPO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129667.1  NP_001129668.1  NP_038461.2  

    ENSEMBL proteins: 
     ENSP00000349321   ENSP00000397379   ENSP00000468698   ENSP00000468434   ENSP00000465625  
     ENSP00000468101   ENSP00000468739   ENSP00000466011   ENSP00000466446   ENSP00000468642  
     ENSP00000467115   ENSP00000466421   ENSP00000407182   ENSP00000389648  

    TNPO2 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNPO2

     
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    antibodies-online proteins for TNPO2 (2 products) 

     
    antibodies-online peptides for TNPO2

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    antibodies-online antibodies for TNPO2 (11 products) 

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    antibodies-online kits for TNPO2 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IPO: Importins

    4 InterPro protein domains:
     IPR000357 HEAT
     IPR011989 ARM-like
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O14787

    ProtoNet protein and cluster: O14787

    2 Blocks protein domains:
    IPB000357 HEAT repeat
    IPB001494 Importin-beta


    UniProtKB/Swiss-Prot: TNPO2_HUMAN, O14787
    Similarity: Belongs to the importin beta family
    Similarity: Contains 13 HEAT repeats
    Similarity: Contains 1 importin N-terminal domain


    Find genes that share domains with TNPO2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNPO2_HUMAN, O14787
    Function: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for
    nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate
    complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently
    translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the
    NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the
    nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be
    conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
    (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI12896982
    GO:0008139nuclear localization sequence binding TAS9298975
    GO:0008536Ran GTPase binding IEA--
         
    Find genes that share ontologies with TNPO2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNPO2
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    miRNA
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    miRTarBase miRNAs that target TNPO2:
    hsa-mir-186-5p (MIRT021089), hsa-mir-125a-5p (MIRT021306), hsa-mir-331-3p (MIRT019238), hsa-mir-191-5p (MIRT021490), hsa-mir-92b-3p (MIRT040668), hsa-mir-25-3p (MIRT050201), hsa-mir-615-3p (MIRT039785), hsa-mir-598-3p (MIRT040490)

    Block miRNA regulation of human, mouse, rat TNPO2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNPO2 (see all 55):
    hsa-miR-136 hsa-miR-3167 hsa-miR-3667-5p hsa-miR-3142 hsa-miR-298 hsa-miR-510 hsa-miR-490-3p hsa-miR-1290
    SwitchGear 3'UTR luciferase reporter plasmidTNPO2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TNPO2

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    GenScript: all cDNA clones in your preferred vector (see all 3): TNPO2 (NM_013433)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNPO2_HUMAN, O14787: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with TNPO2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TNPO2
    Interactions:

        GeneGlobe Interaction Network for TNPO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNPO2 (O147873 ENSP000003973794) via UniProtKB, MINT, STRING, and/or I2D (see all 132)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NXF1Q9UBU93, ENSP000002941724I2D: score=2 STRING: ENSP00000294172
    PTP4A3O753653, ENSP000003322744I2D: score=2 STRING: ENSP00000332274
    ELAVL1Q157173, ENSP000003852694I2D: score=1 STRING: ENSP00000385269
    NUP98P529483, ENSP000003160324I2D: score=1 STRING: ENSP00000316032
    RANP628263, ENSP000003961274I2D: score=1 STRING: ENSP00000396127
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--

    Find genes that share ontologies with TNPO2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNPO2

    1 HMDB Compound for TNPO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNPO2 gene (3 alternative transcripts): 
    NM_001136195.1  NM_001136196.1  NM_013433.4  

    Unigene Cluster for TNPO2:

    Transportin 2
    Hs.416049  [show with all ESTs]
    Unigene Representative Sequence: NM_001136195
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000356861(uc002mup.3 uc002muq.3) ENST00000450764(uc002muo.3)
    ENST00000589149 ENST00000592287 ENST00000588216 ENST00000587155 ENST00000585886
    ENST00000587068 ENST00000589572 ENST00000588491 ENST00000589956 ENST00000588151
    ENST00000586775 ENST00000588484 ENST00000587654 ENST00000589337 ENST00000590781
    ENST00000425528
    miRNA
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    Block miRNA regulation of human, mouse, rat TNPO2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNPO2 (see all 55):
    hsa-miR-136 hsa-miR-3167 hsa-miR-3667-5p hsa-miR-3142 hsa-miR-298 hsa-miR-510 hsa-miR-490-3p hsa-miR-1290
    SwitchGear 3'UTR luciferase reporter plasmidTNPO2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TNPO2
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    GenScript: all cDNA clones in your preferred vector (see all 3): TNPO2 (NM_013433)
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      QuantiTect SYBR Green Assays in human, mouse, rat TNPO2
      QuantiFast Probe-based Assays in human, mouse, rat TNPO2

    Additional mRNA sequence: 

    AB210011.1 AF007748.1 AF019039.1 AK056183.1 AK299485.1 AK307632.1 AL832114.1 BC018314.1 
    BC072420.1 

    Selected DOTS entries (see all 25):

    DT.100785954  DT.100785957  DT.121437190  DT.91987086  DT.100718588  DT.100009746  DT.91909833  DT.443552 
    DT.86859925  DT.100753258  DT.91805659  DT.102841537  DT.426102  DT.91713945  DT.92435863  DT.95214960 
    DT.97859661  DT.121437099  DT.121437111  DT.91785188  DT.92380959  DT.121437107  DT.91823555  DT.92435867 

    Selected AceView cDNA sequences (see all 380):

    AI222226 BM685099 BM976144 BU621378 AL079855 AI246630 AW189326 BE083112 
    BM475252 BU782986 AW005624 AI025278 BF968879 AA485636 AI871327 AA328549 
    BX283543 BG747898 BM982517 AW080477 AA310328 BF848723 CR626762 AU279769 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TNPO2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^
    SP1:                          -     -                                                                                                     -     -               
    SP2:                                -                                                                                                     -     -               
    SP3:                                                                                                                                      -     -               
    SP4:                    -     -     -                                                                                                     -     -               
    SP5:                                                                                                                                            -               

    ExUns: 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b
    SP1:                                      -                                                   
    SP2:                                      -           -                                       
    SP3:                                      -           -                                       
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for TNPO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNPO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTCGAGC
    TNPO2 Expression
    About this image


    TNPO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Telencephalon
    TNPO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNPO2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.416049
        Custom PCR Arrays for TNPO2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNPO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TNPO2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnpo21 , 5 transportin 2 (importin 3, karyopherin beta 2b)1, 5 91.75(n)1
    99.67(a)1
      8 (41.51 cM)5
    2129991  NM_145390.41  NP_663365.31 
     850369155 
    lizard
    (Anolis carolinensis)
    Reptilia TNPO26
    transportin 2
    97(a)
    1 ↔ 1
    GL343286.1(779230-806310)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tnpo21 transportin 2 81.77(n)
    93.91(a)
      100496325  XM_002938477.2  XP_002938523.1 
    zebrafish
    (Danio rerio)
    Actinopterygii iktdsubc_2a72 iktdsubc_2a7 81.08(n)   337801  57060564 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trn6
    CG82196
    --
    72(a)
    58(a)
    many ↔ many
    many ↔ many
    3L(6186580-6193485)
    3L(6193573-6196876)
    worm
    (Caenorhabditis elegans)
    Secernentea imb-26
    Protein IMB-2, isoform a (imb-2) mRNA, complete cd...
    51(a)
    1 → many
    II(14365705-14373870) WBGene00002076
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KAP1046
    Transportin or cytosolic karyopherin beta 2; funct...
    31(a)
    1 → many
    II(270947-273703) YBR017C
    rice
    (Oryza sativa)
    Liliopsida Os.128012 Oryza sativa mRNA for transportin, partial 75.48(n)    AK100077.1 


    ENSEMBL Gene Tree for TNPO2 (if available)
    TreeFam Gene Tree for TNPO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNPO2 gene
    TNPO12  
    2 SIMAP similar genes for TNPO2 using alignment to 9 protein entries:     TNPO2_HUMAN (see all proteins):
    TNPO2 variant protein    TNPO1

    Find genes that share paralogs with TNPO2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNPO2 (see all 590)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2019752981,2
    Cuntested112830100(+) AGGACA/GAAAAT 6 F syn10--------
    rs1840600671,2
    --12409933(+) GAACAC/TGGGAG 1 -- us2k10--------
    rs1400315571,2
    --12409966(+) ATCACA/GCCACT 1 -- us2k10--------
    rs1435550111,2
    --12409987(+) CTGGGC/TGACAG 1 -- us2k10--------
    rs1463367881,2
    --12809581(+) CGGAGC/TAAGAC 3 -- ds50010--------
    rs1165759431,2
    F--12809588(+) AGACCC/TGGTCT 3 -- ds50011Minor allele frequency- T:0.09WA 118
    rs1919061821,2
    --12809589(+) GACCCG/TGTCTC 3 -- ds50010--------
    rs1810067641,2
    --12809590(+) ACCCGG/TTCTCA 3 -- ds50010--------
    rs1158942481,2
    F--12809635(+) TTCCCC/TCCACA 3 -- ds50011Minor allele frequency- T:0.03WA 118
    rs104158311,2
    C,F,A,H--12809726(+) TTCTAT/CGAAAA 3 -- ds500119Minor allele frequency- C:0.22NS EA NA WA CSA 2026

    HapMap Linkage Disequilibrium report for TNPO2 (12810008 - 12834825 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TNPO2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv273009CNV Insertion20981092
    nsv911077CNV Loss21882294
    dgv3733n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): TNPO2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNPO2
    DNA2.0 Custom Variant and Variant Library Synthesis for TNPO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603002    OMIM disorders: --


    Find genes that share disorders with TNPO2           About GenesLikeMe

    Genetic Association Database (GAD): TNPO2

    Export disorders for TNPO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNPO2 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with TNPO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. (PubMed id 9298975)1, 2, 3 Siomi M.C.... Dreyfuss G. (J. Cell Biol. 1997)
    2. Karyopherin beta 2B participates in mRNA export from the nucleus. (PubMed id 12384575)1, 3, 9 Shamsher M.K....Radu A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Transportin2 functions as importin and mediates nuclear import of HuR. (PubMed id 14981248)1, 9 GA1ttinger S....Kutay U. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR. (PubMed id 15037768)1, 9 Rebane A....Steitz J.A. (RNA 2004)
    5. A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling. (PubMed id 12896982)1, 9 Blanc V.... Davidson N.O. (J. Biol. Chem. 2003)
    6. Delineation of mRNA export pathways by the use of cell-permeable peptides. (PubMed id 11729309)1, 9 Gallouzi I.-E. and Steitz J.A. (Science 2001)
    7. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Diagnostic exome sequencing in persons with severe intellectual disability. (PubMed id 23033978)2 de Ligt J.... Vissers L.E. (N. Engl. J. Med. 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 30000 HGNC: 19998 AceView: TNPO2 Ensembl:ENSG00000105576 euGenes: HUgn30000
    ECgene: TNPO2 H-InvDB: TNPO2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNPO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNPO2 gene:
    Search GeneIP for patents involving TNPO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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