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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNPO2 Gene

protein-coding   GIFtS: 54
GCID: GC19M012810

Transportin 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transportin 21 2     Karyopherin Beta 2b1
Importin 31 2     IPO32
Karyopherin Beta-2b2 3     Karyopherin Beta 2b, Transportin2
KPNB2B2 5     Transportin 2 (Importin 3, Karyopherin Beta 2b)2
TRN22 5     transportin-22

External Ids:    HGNC: 199981   Entrez Gene: 300002   Ensembl: ENSG000001055767   OMIM: 6030025   UniProtKB: O147873   

Export aliases for TNPO2 gene to outside databases

Previous GC identifers: GC19M012672 GC19M012673 GC19M012674 GC19M012383


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TNPO2 Gene: 
TNPO2 (transportin 2) is a protein-coding gene. Diseases associated with TNPO2 include sarcoma. GO annotations related to this gene include protein transporter activity and nuclear localization sequence binding. An important paralog of this gene is TNPO1.

UniProtKB/Swiss-Prot: TNPO2_HUMAN, O14787
Function: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for
nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate
complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently
translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the
NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the
nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be
conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
(By similarity)

Gene Wiki entry for TNPO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNPO2 gene promoter:
         Sp1   Pax-6   Nkx2-5   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNPO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNPO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNPO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.13

TNPO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNPO2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M012810:  view genomic region     (about GC identifiers)

Start:
12,810,008 bp from pter      End:
12,834,825 bp from pter
Size:
24,818 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNPO2_HUMAN, O14787 (See protein sequence)
Recommended Name: Transportin-2  
Size: 897 amino acids; 101388 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: O14655 Q6IN77
Alternative splicing: 2 isoforms:  O14787-1   O14787-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNPO2: NX_O14787

Explore proteomics data for TNPO2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14787

  • TNPO2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNPO2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001129667.1  NP_001129668.1  NP_038461.2  

    ENSEMBL proteins: 
     ENSP00000349321   ENSP00000397379   ENSP00000468698   ENSP00000468434   ENSP00000465625  
     ENSP00000468101   ENSP00000468739   ENSP00000466011   ENSP00000466446   ENSP00000468642  
     ENSP00000467115   ENSP00000466421   ENSP00000407182   ENSP00000389648  

    Human Recombinant Protein Products for TNPO2: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNPO2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005643nuclear pore ----
    GO:0005737cytoplasm IEA--

    TNPO2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IPO: Importins

    4 InterPro protein domains:
     IPR000357 HEAT
     IPR011989 ARM-like
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O14787

    ProtoNet protein and cluster: O14787

    2 Blocks protein domains:
    IPB000357 HEAT repeat
    IPB001494 Importin-beta


    UniProtKB/Swiss-Prot: TNPO2_HUMAN, O14787
    Similarity: Belongs to the importin beta family
    Similarity: Contains 13 HEAT repeats
    Similarity: Contains 1 importin N-terminal domain


    TNPO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNPO2_HUMAN, O14787
    Function: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for
    nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate
    complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently
    translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the
    NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the
    nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be
    conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
    (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI12896982
    GO:0008139nuclear localization sequence binding TAS9298975
    GO:0008536Ran GTPase binding IEA--
    GO:0008565protein transporter activity ----
         
    TNPO2 for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidTNPO2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNPO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/24 Interacting proteins for TNPO2 (O147873 ENSP000003973794) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NXF1Q9UBU93, ENSP000002941724I2D: score=2 STRING: ENSP00000294172
    PTP4A3O753653, ENSP000003322744I2D: score=2 STRING: ENSP00000332274
    ELAVL1Q157173, ENSP000003852694I2D: score=1 STRING: ENSP00000385269
    NUP98P529483, ENSP000003160324I2D: score=1 STRING: ENSP00000316032
    RANP628263, ENSP000003961274I2D: score=1 STRING: ENSP00000396127
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--

    TNPO2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNPO2

    1 HMDB Compound for TNPO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about TNPO2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNPO2 gene (3 alternative transcripts): 
    NM_001136195.1  NM_001136196.1  NM_013433.4  

    Unigene Cluster for TNPO2:

    Transportin 2
    Hs.416049  [show with all ESTs]
    Unigene Representative Sequence: NM_001136195
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000356861(uc002mup.3 uc002muq.3) ENST00000450764(uc002muo.3)
    ENST00000589149 ENST00000592287 ENST00000588216 ENST00000587155 ENST00000585886
    ENST00000587068 ENST00000589572 ENST00000588491 ENST00000589956 ENST00000588151
    ENST00000586775 ENST00000588484 ENST00000587654 ENST00000589337 ENST00000590781
    ENST00000425528
    miRNA
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate TNPO2 (see all 55):
    hsa-miR-136 hsa-miR-3167 hsa-miR-3667-5p hsa-miR-3142 hsa-miR-298 hsa-miR-510 hsa-miR-490-3p hsa-miR-1290
    SwitchGear 3'UTR luciferase reporter plasmidTNPO2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB210011.1 AF007748.1 AF019039.1 AK056183.1 AK299485.1 AK307632.1 AL832114.1 BC018314.1 
    BC072420.1 

    24/25 DOTS entries (see all 25):

    DT.100785954  DT.100785957  DT.121437190  DT.91987086  DT.100718588  DT.100009746  DT.91909833  DT.443552 
    DT.86859925  DT.100753258  DT.91805659  DT.102841537  DT.426102  DT.91713945  DT.92435863  DT.95214960 
    DT.97859661  DT.121437099  DT.121437111  DT.91785188  DT.92380959  DT.121437107  DT.91823555  DT.92435867 

    24/380 AceView cDNA sequences (see all 380):

    AA325412 BM126179 AA331218 NM_013433 AW088621 F05132 AI871327 AW080477 
    CR615070 BM452067 BU621378 AW262955 F05666 AI203385 AI222226 AU119841 
    AA889538 BM475252 BX283543 BM982517 AI246630 BU949054 AA938007 AI073891 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TNPO2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^
    SP1:                          -     -                                                                                                     -     -               
    SP2:                                -                                                                                                     -     -               
    SP3:                                                                                                                                      -     -               
    SP4:                    -     -     -                                                                                                     -     -               
    SP5:                                                                                                                                            -               

    ExUns: 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b
    SP1:                                      -                                                   
    SP2:                                      -           -                                       
    SP3:                                      -           -                                       
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for TNPO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNPO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTCGAGC
    TNPO2 Expression
    About this image


    See TNPO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNPO2

    SOURCE GeneReport for Unigene cluster: Hs.416049
        SABiosciences Custom PCR Arrays for TNPO2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNPO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TNPO2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnpo21 , 5 transportin 2 (importin 3, karyopherin beta 2b)1, 5 91.75(n)1
    99.67(a)1
      8 (41.51 cM)5
    2129991  NM_001122843.11  NP_001116315.11 
     850369155 
    lizard
    (Anolis carolinensis)
    Reptilia TNPO26
    Uncharacterized protein
    96(a)
    1 ↔ 1
    GL343286.1(779230-806310)
    zebrafish
    (Danio rerio)
    Actinopterygii iktdsubc_2a72 iktdsubc_2a7 81.08(n)   337801  57060564 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trn6
    CG82196
    --
    72(a)
    58(a)
    many ↔ many
    many ↔ many
    3L(6186580-6193485)
    3L(6193573-6196876)
    worm
    (Caenorhabditis elegans)
    Secernentea imb-26
    Protein IMB-2, isoform a
    52(a)
    1 → many
    II(14365705-14373450)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KAP1046
    Transportin or cytosolic karyopherin beta 2; funct...
    31(a)
    1 → many
    II(270947-273703)
    rice
    (Oryza sativa)
    Liliopsida Os.128012 Oryza sativa mRNA for transportin, partial 75.48(n)    AK100077.1 


    ENSEMBL Gene Tree for TNPO2 (if available)
    TreeFam Gene Tree for TNPO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNPO2 gene
    TNPO12  
    2 SIMAP similar genes for TNPO2 using alignment to 9 protein entries:     TNPO2_HUMAN (see all proteins):
    TNPO2 variant protein    TNPO1

    TNPO2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/590 SNPs in TNPO2 are shown (see all 590)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2019752981,2
    Cuntested112830100(+) AGGACA/GAAAAT 6 F syn10--------
    VAR_0693734
    ----see VAR_0693732 W C mis40--------
    rs1840600671,2
    --12409933(+) GAACAC/TGGGAG 1 -- us2k10--------
    rs1400315571,2
    --12409966(+) ATCACA/GCCACT 1 -- us2k10--------
    rs1435550111,2
    --12409987(+) CTGGGC/TGACAG 1 -- us2k10--------
    rs1463367881,2
    --12809581(+) CGGAGC/TAAGAC 3 -- ds50010--------
    rs1165759431,2
    F--12809588(+) AGACCC/TGGTCT 3 -- ds50011Minor allele frequency- T:0.09WA 118
    rs1919061821,2
    --12809589(+) GACCCG/TGTCTC 3 -- ds50010--------
    rs1810067641,2
    --12809590(+) ACCCGG/TTCTCA 3 -- ds50010--------
    rs1158942481,2
    F--12809635(+) TTCCCC/TCCACA 3 -- ds50011Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for TNPO2 (12810008 - 12834825 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TNPO2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv273009CNV Insertion20981092
    nsv911077CNV Loss21882294
    dgv3733n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): TNPO2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TNPO2
    DNA2.0 Custom Variant and Variant Library Synthesis for TNPO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603002    OMIM disorders: --

    2 diseases for TNPO2:    About MalaCards
    sarcoma    


    TNPO2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TNPO2

    Export disorders for TNPO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNPO2 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with TNPO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. (PubMed id 9298975)1, 2, 3 Siomi M.C.... Dreyfuss G. (1997)
    2. Karyopherin beta 2B participates in mRNA export from the nucleus. (PubMed id 12384575)1, 3, 9 Shamsher M.K....Radu A. (2002)
    3. Transportin2 functions as importin and mediates nuclear import of HuR. (PubMed id 14981248)1, 9 Guttinger S....Kutay U. (2004)
    4. Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR. (PubMed id 15037768)1, 9 Rebane A....Steitz J.A. (2004)
    5. A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling. (PubMed id 12896982)1, 9 Blanc V.... Davidson N.O. (2003)
    6. Delineation of mRNA export pathways by the use of cell-permeable peptides. (PubMed id 11729309)1, 9 Gallouzi I.-E. and Steitz J.A. (2001)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Diagnostic exome sequencing in persons with severe intellectual disability. (PubMed id 23033978)2 de Ligt J.... Vissers L.E. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 30000 HGNC: 19998 AceView: TNPO2 Ensembl:ENSG00000105576 euGenes: HUgn30000
    ECgene: TNPO2 H-InvDB: TNPO2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNPO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNPO2 gene:
    Search GeneIP for patents involving TNPO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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