Aliases for TNPO2 Gene
External Ids for TNPO2 Gene
GeneCards Summary for TNPO2 Gene
TNPO2 (Transportin 2) is a Protein Coding gene. GO annotations related to this gene include Ran GTPase binding and nuclear localization sequence binding. An important paralog of this gene is TNPO1.
UniProtKB/Swiss-Prot for TNPO2 Gene
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).