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Aliases for TNPO2 Gene

Aliases for TNPO2 Gene

  • Transportin 2 2 3
  • Karyopherin Beta-2b 3 4
  • Importin 3 2 3
  • KPNB2B 3 6
  • TRN2 3 6
  • Transportin 2 (Importin 3, Karyopherin Beta 2b) 3
  • Karyopherin Beta 2b, Transportin 3
  • Karyopherin Beta 2b 2
  • Transportin-2 3
  • IPO3 3

External Ids for TNPO2 Gene

Previous GeneCards Identifiers for TNPO2 Gene

  • GC19M012672
  • GC19M012673
  • GC19M012674
  • GC19M012810
  • GC19M012383

Summaries for TNPO2 Gene

GeneCards Summary for TNPO2 Gene

TNPO2 (Transportin 2) is a Protein Coding gene. GO annotations related to this gene include Ran GTPase binding and nuclear localization sequence binding. An important paralog of this gene is TNPO1.

UniProtKB/Swiss-Prot for TNPO2 Gene

  • Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).

Gene Wiki entry for TNPO2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNPO2 Gene

Genomics for TNPO2 Gene

Regulatory Elements for TNPO2 Gene

Genomic Location for TNPO2 Gene

Start:
12,699,194 bp from pter
End:
12,724,011 bp from pter
Size:
24,818 bases
Orientation:
Minus strand

Genomic View for TNPO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNPO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNPO2 Gene

Proteins for TNPO2 Gene

  • Protein details for TNPO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14787-TNPO2_HUMAN
    Recommended name:
    Transportin-2
    Protein Accession:
    O14787
    Secondary Accessions:
    • O14655
    • Q6IN77

    Protein attributes for TNPO2 Gene

    Size:
    897 amino acids
    Molecular mass:
    101388 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TNPO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNPO2 Gene

Proteomics data for TNPO2 Gene at MOPED

Post-translational modifications for TNPO2 Gene

  • Ubiquitination at Lys71, Lys484, and Lys862
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TNPO2 Gene

Domains for TNPO2 Gene

Gene Families for TNPO2 Gene

HGNC:
  • IPO :Importins

Protein Domains for TNPO2 Gene

Suggested Antigen Peptide Sequences for TNPO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14787

UniProtKB/Swiss-Prot:

TNPO2_HUMAN :
  • O14787
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the importin beta family. Importin beta-2 subfamily.
Similarity:
  • Contains 20 HEAT repeats.
genes like me logo Genes that share domains with TNPO2: view

Function for TNPO2 Gene

Molecular function for TNPO2 Gene

UniProtKB/Swiss-Prot Function: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).

Gene Ontology (GO) - Molecular Function for TNPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 12896982
GO:0008139 nuclear localization sequence binding TAS 9298975
GO:0008536 Ran GTPase binding IEA --
genes like me logo Genes that share ontologies with TNPO2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TNPO2 Gene

Localization for TNPO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNPO2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNPO2 Gene COMPARTMENTS Subcellular localization image for TNPO2 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TNPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TNPO2: view

Pathways for TNPO2 Gene

SuperPathways for TNPO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TNPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
genes like me logo Genes that share ontologies with TNPO2: view

No data available for Pathways by source for TNPO2 Gene

Compounds for TNPO2 Gene

(1) HMDB Compounds for TNPO2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with TNPO2: view

Transcripts for TNPO2 Gene

Unigene Clusters for TNPO2 Gene

Transportin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNPO2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - - - -
SP5: -
SP6: -
SP7: - - -
SP8:

ExUns: 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1: -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8: -

Relevant External Links for TNPO2 Gene

GeneLoc Exon Structure for
TNPO2
ECgene alternative splicing isoforms for
TNPO2

Expression for TNPO2 Gene

mRNA expression in normal human tissues for TNPO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNPO2 Gene

SOURCE GeneReport for Unigene cluster for TNPO2 Gene Hs.416049

genes like me logo Genes that share expressions with TNPO2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TNPO2 Gene

Orthologs for TNPO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TNPO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNPO2 35
  • 99.52 (n)
  • 100 (a)
TNPO2 36
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNPO2 35
  • 93.05 (n)
  • 99.67 (a)
TNPO2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNPO2 35
  • 92.72 (n)
  • 99.89 (a)
TNPO2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnpo2 35
  • 91.75 (n)
  • 99.67 (a)
Tnpo2 16
Tnpo2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNPO2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNPO2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnpo2 35
  • 91.92 (n)
  • 99.66 (a)
lizard
(Anolis carolinensis)
Reptilia TNPO2 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnpo2 35
  • 81.77 (n)
  • 93.91 (a)
zebrafish
(Danio rerio)
Actinopterygii iktdsubc_2a7 35
tnpo2 35
  • 79.52 (n)
  • 90.08 (a)
tnpo2 36
  • 90 (a)
OneToMany
TNPO2 (2 of 2) 36
  • 95 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8219 36
  • 58 (a)
ManyToMany
Trn 36
  • 72 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea imb-2 36
  • 51 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAP104 36
  • 31 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.12801 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5618 36
  • 70 (a)
OneToMany
Species with no ortholog for TNPO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNPO2 Gene

ENSEMBL:
Gene Tree for TNPO2 (if available)
TreeFam:
Gene Tree for TNPO2 (if available)

Paralogs for TNPO2 Gene

Paralogs for TNPO2 Gene

genes like me logo Genes that share paralogs with TNPO2: view

Variants for TNPO2 Gene

Sequence variations from dbSNP and Humsavar for TNPO2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs9467 -- 12,699,465(+) TTTTT(A/T)AAAAA utr-variant-3-prime
rs722571 -- 12,700,565(-) GACCC(A/G)CTCCA utr-variant-3-prime
rs722572 -- 12,700,231(-) CGTTT(A/G)ATTGA utr-variant-3-prime
rs729767 -- 12,718,649(-) GCAGA(C/G)CCTTT intron-variant
rs1063903 -- 12,699,466(-) TTTTT(A/T)TAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TNPO2 Gene

Variant ID Type Subtype PubMed ID
dgv3733n71 CNV Loss 21882294
nsv911077 CNV Loss 21882294
esv273009 CNV Insertion 20981092

Relevant External Links for TNPO2 Gene

HapMap Linkage Disequilibrium report
TNPO2
Human Gene Mutation Database (HGMD)
TNPO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNPO2 Gene

Disorders for TNPO2 Gene

Relevant External Links for TNPO2

Genetic Association Database (GAD)
TNPO2
genes like me logo Genes that share disorders with TNPO2: view

No data available for UniProtKB/Swiss-Prot for TNPO2 Gene

Publications for TNPO2 Gene

  1. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. (PMID: 9298975) Siomi M.C. … Dreyfuss G. (J. Cell Biol. 1997) 2 3 4
  2. Karyopherin beta 2B participates in mRNA export from the nucleus. (PMID: 12384575) Shamsher M.K. … Radu A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 23
  3. A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling. (PMID: 12896982) Blanc V. … Davidson N.O. (J. Biol. Chem. 2003) 3 23
  4. Transportin2 functions as importin and mediates nuclear import of HuR. (PMID: 14981248) GA1ttinger S. … Kutay U. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 23
  5. Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR. (PMID: 15037768) Rebane A. … Steitz J.A. (RNA 2004) 3 23

Products for TNPO2 Gene

Sources for TNPO2 Gene

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