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Aliases for TNPO1 Gene

Aliases for TNPO1 Gene

  • Transportin 1 2 3
  • KPNB2 3 4 6
  • MIP1 3 4 6
  • Karyopherin (Importin) Beta 2 2 3
  • M9 Region Interaction Protein 3 4
  • Karyopherin Beta-2 3 4
  • Importin Beta-2 3 4
  • Importin 2 2 3
  • TRN 3 4
  • MIP 3 4
  • Importin Beta 2 3
  • Transportin-1 3
  • IPO2 3

External Ids for TNPO1 Gene

Previous HGNC Symbols for TNPO1 Gene

  • KPNB2

Previous GeneCards Identifiers for TNPO1 Gene

  • GC05P072196
  • GC05P072148
  • GC05P067317

Summaries for TNPO1 Gene

Entrez Gene Summary for TNPO1 Gene

  • This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNPO1 Gene

TNPO1 (Transportin 1) is a Protein Coding gene. Diseases associated with TNPO1 include retinitis pigmentosa 2. Among its related pathways are GPCR Pathway and Gene Expression. GO annotations related to this gene include Ran GTPase binding and nuclear localization sequence binding. An important paralog of this gene is TNPO2.

UniProtKB/Swiss-Prot for TNPO1 Gene

  • Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner.

Gene Wiki entry for TNPO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNPO1 Gene

Genomics for TNPO1 Gene

Regulatory Elements for TNPO1 Gene

Genomic Location for TNPO1 Gene

Start:
72,816,312 bp from pter
End:
72,916,733 bp from pter
Size:
100,422 bases
Orientation:
Plus strand

Genomic View for TNPO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNPO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNPO1 Gene

Proteins for TNPO1 Gene

  • Protein details for TNPO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92973-TNPO1_HUMAN
    Recommended name:
    Transportin-1
    Protein Accession:
    Q92973
    Secondary Accessions:
    • B4DVC6
    • Q92957
    • Q92975

    Protein attributes for TNPO1 Gene

    Size:
    898 amino acids
    Molecular mass:
    102355 Da
    Quaternary structure:
    • Binds HNRPA1, HNRPA2, HNRNPDL, RPL23A, RPS7, RPL5, RAN and SRP19. Interacts with H2A, H2B, H3 and H4 histones. Binds to HIV-1 Rev. Interacts with isoform 5 of ADAR/ADAR1 (via DRBM 3 domain). Interacts with SNAI1 (via zinc fingers); the interaction mediates SNAI1 nuclear import. Interacts with SNAI2 (via zinc fingers).
    SequenceCaution:
    • Sequence=AAC50723.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH40340.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNPO1 Gene

    Alternative splice isoforms for TNPO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNPO1 Gene

Proteomics data for TNPO1 Gene at MOPED

Post-translational modifications for TNPO1 Gene

  • Ubiquitination at Lys81, Lys85, Lys192, Lys495, and Lys863
  • Modification sites at PhosphoSitePlus

Other Protein References for TNPO1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TNPO1 Gene

Domains for TNPO1 Gene

Gene Families for TNPO1 Gene

HGNC:
  • IPO :Importins

Protein Domains for TNPO1 Gene

Suggested Antigen Peptide Sequences for TNPO1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92973

UniProtKB/Swiss-Prot:

TNPO1_HUMAN :
  • Q92973
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the importin beta family. Importin beta-2 subfamily.
Similarity:
  • Contains 20 HEAT repeats.
genes like me logo Genes that share domains with TNPO1: view

Function for TNPO1 Gene

Molecular function for TNPO1 Gene

UniProtKB/Swiss-Prot Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner.

Gene Ontology (GO) - Molecular Function for TNPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 10353245
GO:0008139 nuclear localization sequence binding TAS 8808633
GO:0008536 Ran GTPase binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TNPO1: view

Phenotypes for TNPO1 Gene

GenomeRNAi human phenotypes for TNPO1:
genes like me logo Genes that share phenotypes with TNPO1: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNPO1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TNPO1 Gene

Localization for TNPO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNPO1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNPO1 Gene COMPARTMENTS Subcellular localization image for TNPO1 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TNPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 9144189
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 18570454
GO:0072372 primary cilium TAS --
genes like me logo Genes that share ontologies with TNPO1: view

Pathways for TNPO1 Gene

genes like me logo Genes that share pathways with TNPO1: view

Gene Ontology (GO) - Biological Process for TNPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation TAS 9144189
GO:0006886 intracellular protein transport --
GO:0006996 organelle organization TAS --
GO:0010467 gene expression TAS --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with TNPO1: view

Compounds for TNPO1 Gene

(1) HMDB Compounds for TNPO1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(4) Novoseek inferred chemical compound relationships for TNPO1 Gene

Compound -log(P) Hits PubMed IDs
mcp 1 74.8 1
rantes 68.4 9
gdp 26.4 1
calcium 0 1
genes like me logo Genes that share compounds with TNPO1: view

Transcripts for TNPO1 Gene

Unigene Clusters for TNPO1 Gene

Transportin 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNPO1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNPO1 Gene

No ASD Table

Relevant External Links for TNPO1 Gene

GeneLoc Exon Structure for
TNPO1
ECgene alternative splicing isoforms for
TNPO1

Expression for TNPO1 Gene

mRNA expression in normal human tissues for TNPO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNPO1 Gene

SOURCE GeneReport for Unigene cluster for TNPO1 Gene Hs.482497

genes like me logo Genes that share expressions with TNPO1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TNPO1 Gene

Orthologs for TNPO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TNPO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNPO1 35
  • 99.81 (n)
  • 100 (a)
TNPO1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNPO1 35
  • 95.36 (n)
  • 99.78 (a)
TNPO1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNPO1 35
  • 95.19 (n)
  • 99.53 (a)
TNPO1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnpo1 35
  • 90.79 (n)
  • 99.67 (a)
Tnpo1 16
Tnpo1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNPO1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNPO1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnpo1 35
  • 90.56 (n)
  • 99.44 (a)
chicken
(Gallus gallus)
Aves TNPO1 35
  • 86.98 (n)
  • 96.54 (a)
TNPO1 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNPO1 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1493 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tnpo1 35
  • 83.26 (n)
  • 95.39 (a)
zebrafish
(Danio rerio)
Actinopterygii tnpo1 35
  • 77.94 (n)
  • 92.36 (a)
tnpo1 36
  • 92 (a)
OneToMany
TNPO1 (2 of 2) 36
  • 80 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005892 35
  • 65.2 (n)
  • 75.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8219 36
  • 60 (a)
ManyToMany
Trn 35
  • 66.03 (n)
  • 74.35 (a)
Trn 36
  • 74 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea imb-2 35
  • 55.25 (n)
  • 52.74 (a)
imb-2 36
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAP104 36
  • 32 (a)
OneToMany
KAP104 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TRN1 35
  • 52.51 (n)
  • 46.3 (a)
rice
(Oryza sativa)
Liliopsida Os04g0691500 35
  • 53.06 (n)
  • 49.56 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03690 35
  • 48.21 (n)
  • 39.11 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes kap104 35
  • 52.71 (n)
  • 46.94 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9387 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5618 36
  • 72 (a)
OneToMany
Species with no ortholog for TNPO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNPO1 Gene

ENSEMBL:
Gene Tree for TNPO1 (if available)
TreeFam:
Gene Tree for TNPO1 (if available)

Paralogs for TNPO1 Gene

Paralogs for TNPO1 Gene

Selected SIMAP similar genes for TNPO1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TNPO1: view

Variants for TNPO1 Gene

Sequence variations from dbSNP and Humsavar for TNPO1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs7879 -- 72,914,309(-) GTAAA(A/T)ACAAA utr-variant-3-prime
rs17606 -- 72,888,271(+) CTGGA(C/T)AGCAA reference, synonymous-codon
rs34645 -- 72,817,426(-) GGCCA(A/G)TCTGC intron-variant
rs34646 -- 72,817,234(-) TGGGC(A/C/G/T)CTGTG intron-variant
rs34647 -- 72,816,603(-) CCCGC(C/G)GCGGG utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TNPO1 Gene

Variant ID Type Subtype PubMed ID
nsv882180 CNV Loss 21882294
nsv525479 CNV Loss 19592680
nsv830343 CNV Loss 17160897
dgv6180n71 CNV Loss 21882294
dgv6181n71 CNV Loss 21882294
esv2730296 CNV Deletion 23290073
esv2730297 CNV Deletion 23290073

Relevant External Links for TNPO1 Gene

HapMap Linkage Disequilibrium report
TNPO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNPO1 Gene

Disorders for TNPO1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TNPO1 Gene including...

Search for TNPO1 Gene in MalaCards »

(3) Novoseek inferred disease relationships for TNPO1 Gene

Disease -log(P) Hits PubMed IDs
hiv infections 13.3 2
inflammation 0 1
tumors 0 1
genes like me logo Genes that share disorders with TNPO1: view

No data available for UniProtKB/Swiss-Prot for TNPO1 Gene

Publications for TNPO1 Gene

  1. Karyopherin beta2 mediates nuclear import of a mRNA binding protein. (PMID: 9144189) Bonifaci N. … Blobel G. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp. (PMID: 10353245) Chook Y.M. … Blobel G. (Nature 1999) 3 4 23
  3. RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1. (PMID: 19124606) Fritz J. … Jantsch M.F. (Mol. Cell. Biol. 2009) 3 4 23
  4. A novel receptor-mediated nuclear protein import pathway. (PMID: 8808633) Pollard V.W. … Dreyfuss G. (Cell 1996) 2 3 4
  5. Transportin: nuclear transport receptor of a novel nuclear protein import pathway. (PMID: 8986607) Nakielny S. … Dreyfuss G. (Exp. Cell Res. 1996) 3 4

Products for TNPO1 Gene

Sources for TNPO1 Gene

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