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TNPO1 Gene

protein-coding   GIFtS: 62
GCID: GC05P072148

Transportin 1

(Previous name: karyopherin (importin) beta 2)
(Previous symbol: KPNB2)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transportin 11 2     MIP2 3
KPNB21 2 3 5     TRN2 3
MIP12 3 5     M9 Region Interaction Protein2 3
Karyopherin (Importin) Beta 21 2     IPO22
Importin 21 2     Importin Beta 22
Importin Beta-22 3     transportin-12
Karyopherin Beta-22 3     

External Ids:    HGNC: 64011   Entrez Gene: 38422   Ensembl: ENSG000000833127   OMIM: 6029015   UniProtKB: Q929733   

Export aliases for TNPO1 gene to outside databases

Previous GC identifers: GC05P072196 GC05P067317


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNPO1 Gene:
This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization
signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha
subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at
nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TNPO1 Gene:
TNPO1 (transportin 1) is a protein-coding gene. Diseases associated with TNPO1 include retinitis pigmentosa 2, and legionnaires' disease. GO annotations related to this gene include nuclear localization sequence binding and Ran GTPase binding. An important paralog of this gene is TNPO2.

UniProtKB/Swiss-Prot: TNPO1_HUMAN, Q92973
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear
localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex
to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds
to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by
an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By
similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of
the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also
to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and
RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of
H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of
HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner

Gene Wiki entry for TNPO1 (Transportin 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNPO1 gene promoter:
         GR   Sox5   SREBP-1c   GR-beta   FOXD3   AP-4   SREBP-1b   YY1   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNPO1 promoter sequence
   Search Chromatin IP Primers for TNPO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNPO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.2   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13.1

TNPO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNPO1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P072148:  view genomic region     (about GC identifiers)

Start:
72,112,139 bp from pter      End:
72,212,560 bp from pter
Size:
100,422 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TNPO1_HUMAN, Q92973 (See protein sequence)
Recommended Name: Transportin-1  
Size: 898 amino acids; 102355 Da
Subunit: Binds HNRPA1, HNRPA2, HNRNPDL, RPL23A, RPS7, RPL5, RAN and SRP19. Interacts with H2A, H2B, H3 and H4
histones. Binds to HIV-1 Rev. Interacts with isoform 5 of ADAR/ADAR1 (via DRBM 3 domain). Interacts with SNAI1
(via zinc fingers); the interaction mediates SNAI1 nuclear import. Interacts with SNAI2 (via zinc fingers)
Sequence caution: Sequence=AAC50723.1; Type=Erroneous initiation; Sequence=AAH40340.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for TNPO1 (see all 12):
1QBK (3D)        2H4M (3D)        2OT8 (3D)        2QMR (3D)        2Z5J (3D)        2Z5K (3D)    
Secondary accessions: B4DVC6 Q92957 Q92975
Alternative splicing: 3 isoforms:  Q92973-1   Q92973-2   Q92973-3   

Explore the universe of human proteins at neXtProt for TNPO1: NX_Q92973

Explore proteomics data for TNPO1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys81, Lys85, Lys192, Lys495, Lys863
  • Modification sites at PhosphoSitePlus

  • See TNPO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002261.3  NP_694858.1  

    ENSEMBL proteins: 
     ENSP00000336712   ENSP00000430312   ENSP00000428899   ENSP00000425118   ENSP00000474059  
     ENSP00000398524   ENSP00000415164  
    Reactome Protein details: Q92973

    TNPO1 Human Recombinant Protein Products:

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    Novus Biologicals TNPO1 Protein
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    Cloud-Clone Corp. Proteins for TNPO1

    TNPO1 Antibody Products:

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    TNPO1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TNPO1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TNPO1
    Cloud-Clone Corp. CLIAs for TNPO1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IPO: Importins

    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q92973

    ProtoNet protein and cluster: Q92973

    3 Blocks protein domains:
    IPB000225 Armadillo repeat
    IPB000357 HEAT repeat
    IPB001494 Importin-beta


    UniProtKB/Swiss-Prot: TNPO1_HUMAN, Q92973
    Similarity: Belongs to the importin beta family
    Similarity: Contains 8 HEAT repeats
    Similarity: Contains 1 importin N-terminal domain


    TNPO1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNPO1_HUMAN, Q92973
    Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear
    localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex
    to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
    through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds
    to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
    cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by
    an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By
    similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of
    the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also
    to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and
    RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of
    H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of
    HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI10353245
    GO:0008139nuclear localization sequence binding TAS8808633
    GO:0008536Ran GTPase binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    TNPO1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNPO1:
     Cell division defect  Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNPO1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNPO1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNPO1

    miRNA
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    miRTarBase miRNAs that target TNPO1:
    hsa-mir-155-5p (MIRT021043), hsa-mir-210-3p (MIRT003172), hsa-mir-18a-5p (MIRT050674), hsa-mir-21-5p (MIRT031064), hsa-mir-34a-5p (MIRT025575), hsa-mir-16-5p (MIRT032051), hsa-mir-124-3p (MIRT023181), hsa-mir-92a-3p (MIRT049301), hsa-let-7b-5p (MIRT052319)

    Block miRNA regulation of human, mouse, rat TNPO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNPO1 (see all 172):
    hsa-miR-411* hsa-miR-640 hsa-miR-3938 hsa-miR-128 hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-3622b-3p hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat TNPO1

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNPO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNPO1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNPO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNPO1_HUMAN, Q92973: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS9144189
    GO:0005829cytosol TAS--

    TNPO1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNPO1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.62
    Destabilization of mRNA by Tristetraprolin (TTP)0.00
    2GPCR Pathway
    NFAT in Immune Response0.58
    3Chks in Checkpoint Regulation
    SREBP Proteolysis0.43
    4Gene Expression
    Gene Expression0.40
    5Ran Pathway
    Ran Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNPO1
        Ran Pathway
    SREBP Proteolysis
    NFAT in Immune Response

    2 GeneGo (Thomson Reuters) Pathways for TNPO1
        Cell cycle Spindle assembly and chromosome separation
    Development TGF-beta receptor signaling

    1 Reactome Pathway for TNPO1
        Tristetraprolin (TTP) destabilizes mRNA



    TNPO1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TNPO1
    Interactions:

        GeneGlobe Interaction Network for TNPO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNPO1 (Q929731, 2, 3 ENSP000003367124) via UniProtKB, MINT, STRING, and/or I2D (see all 742)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NXF1Q9UBU92, 3, ENSP000002941724MINT-15485 MINT-15486 I2D: score=3 STRING: ENSP00000294172
    GCN1L1Q926162, 3, ENSP000003006484MINT-7947479 I2D: score=4 STRING: ENSP00000300648
    ELAVL1Q157172, 3, ENSP000003852694MINT-7947479 I2D: score=1 STRING: ENSP00000385269
    GRB2P629931, 3, ENSP000003390074EBI-286693,EBI-401755 I2D: score=1 STRING: ENSP00000339007
    PLK1P533502, 3, ENSP000003000934MINT-7947479 I2D: score=1 STRING: ENSP00000300093
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation TAS9144189
    GO:0006886intracellular protein transport ----
    GO:0010467gene expression TAS--
    GO:0016032viral process IEA--
    GO:0016070RNA metabolic process TAS--

    TNPO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNPO1

    1 HMDB Compound for TNPO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    4 Novoseek inferred chemical compound relationships for TNPO1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mcp 1 74.8 1 7589134 (1)
    rantes 68.4 10 9247020 (1), 11391951 (1), 19397398 (1), 10876908 (1) (see all 9)
    gdp 26.4 1 10353245 (1)
    calcium 0 1 9702779 (1)



    TNPO1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TNPO1 gene (2 alternative transcripts): 
    NM_002270.3  NM_153188.2  

    Unigene Cluster for TNPO1:

    Transportin 1
    Hs.482497  [show with all ESTs]
    Unigene Representative Sequence: NM_002270
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337273(uc011csi.1 uc003kck.4 uc003kci.4 uc003kcg.4)
    ENST00000515483 ENST00000520850 ENST00000523768 ENST00000518279 ENST00000513944
    ENST00000506351 ENST00000509030 ENST00000511754 ENST00000506528 ENST00000508762
    ENST00000505082 ENST00000605210 ENST00000503084 ENST00000454282(uc011csj.1)
    ENST00000447967
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate TNPO1 (see all 172):
    hsa-miR-411* hsa-miR-640 hsa-miR-3938 hsa-miR-128 hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-3622b-3p hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): TNPO1 (NM_002270)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNPO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNPO1
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat TNPO1

    Additional mRNA sequence: 

    AK055669.1 AK090518.1 AK124768.1 AK299671.1 AK301021.1 AK308177.1 AL049378.1 BC040340.1 
    U70322.1 U72069.1 U72395.1 

    Selected DOTS entries (see all 37):

    DT.442028  DT.446733  DT.92443089  DT.97826902  DT.100794057  DT.91962001  DT.100694075  DT.100746266 
    DT.120837612  DT.120837566  DT.100778665  DT.95102393  DT.95181779  DT.120837683  DT.95181785  DT.100794062 
    DT.100794059  DT.100803960  DT.100805598  DT.120837684  DT.121212872  DT.91853984  DT.92443090  DT.95181783 

    Selected AceView cDNA sequences (see all 603):

    AI953905 BU509669 AL603416 BG109768 AA825705 AA453318 BF221744 AI867579 
    BQ026099 BP872225 CB216416 CB044442 AA931074 BF476146 BQ922510 BG674629 
    CR592982 BF589499 BQ423313 AU123781 AI393489 BM670770 AA897275 AI654423 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNPO1 expression in normal human tissues (normalized intensities)      TNPO1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TNPO1 Expression
    About this image


    TNPO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TNPO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNPO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.482497
        Custom PCR Arrays for TNPO1
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TNPO1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNPO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TNPO1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnpo11 , 5 transportin 11, 5 90.79(n)1
    99.67(a)1
      13 (52.24 cM)5
    2387991  NM_178716.31  NP_848831.21 
     988390195 
    chicken
    (Gallus gallus)
    Aves TNPO11 transportin 1 86.98(n)
    96.54(a)
      427218  XM_424806.4  XP_424806.3 
    lizard
    (Anolis carolinensis)
    Reptilia TNPO16
    transportin 1
    97(a)
    1 ↔ 1
    2(16274254-16307859)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.14932 Xenopus laevis transportin mRNA, partial cds 86.68(n)    AF059614.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tnpo11 transportin 1 77.94(n)
    92.36(a)
      562607  XM_005171979.1  XP_005172036.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trn1 Transportin 66.03(n)
    74.35(a)
      38721  NM_058020.4  NP_477368.1 
    worm
    (Caenorhabditis elegans)
    Secernentea imb-21 imb-2 55.25(n)
    52.74(a)
      175094  NM_064586.3  NP_496987.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KAP104(YBR017C)4 Transportin or cytosolic karyopherin beta 2; functions more   --   2(273703-270947) 852305  NP_009573.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TRN11 TRN1 52.51(n)
    46.3(a)
      816198  NM_127248.4  NP_179287.3 
    rice
    (Oryza sativa)
    Liliopsida Os04g06915001 Os04g0691500 53.06(n)
    49.56(a)
      4337505  NM_001060894.2  NP_001054359.2 


    ENSEMBL Gene Tree for TNPO1 (if available)
    TreeFam Gene Tree for TNPO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNPO1 gene
    TNPO22  
    2 SIMAP similar genes for TNPO1 using alignment to 4 protein entries:     TNPO1_HUMAN (see all proteins):
    TNPO2    TNPO2 variant protein

    TNPO1 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for TNPO1
    PGOHUM00000238863 PGOHUM00000262947 PGOHUM00000262948 PGOHUM00000256819 PGOHUM00000256820


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNPO1 (see all 1818)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830403711,2
    --72110507(+) TAAAGA/GGAAAA 1 -- us2k10--------
    rs47040401,2
    C,F,A,H--72110515(+) AAATAC/TTACTG 1 -- us2k17Minor allele frequency- T:0.41NA WA EA 366
    rs117415771,2
    C,F,H--72110573(+) CCATGT/CTAATA 1 -- us2k1 tfbs36Minor allele frequency- C:0.17NA WA CSA EA 364
    rs1448388501,2
    C--72110645(+) AAAAAA/GGCTAC 1 -- us2k10--------
    rs1387792411,2
    C--72110746(+) TAATCC/TCAATT 1 -- us2k10--------
    rs1863016761,2
    C--72110780(+) TTTTTC/TCTTTC 1 -- us2k10--------
    rs1417235521,2
    --72111074(+) AAATAC/TACTTT 1 -- us2k10--------
    rs1897920081,2
    --72111110(+) AACTAA/CCATTC 1 -- us2k10--------
    rs342797101,2
    C--72111161(+) TATTTG/-GGGGG 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1503598461,2
    C--72111258(+) TCTATA/TTTTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TNPO1 (72112139 - 72212560 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TNPO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730296CNV Deletion23290073
    esv2730297CNV Deletion23290073
    dgv6181n71CNV Loss21882294
    nsv830343CNV Loss17160897
    dgv6180n71CNV Loss21882294
    nsv882180CNV Loss21882294
    nsv525479CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNPO1
    DNA2.0 Custom Variant and Variant Library Synthesis for TNPO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602901    OMIM disorders: --

    Selected diseases for TNPO1 (see all 24):    About MalaCards
    retinitis pigmentosa 2    legionnaires' disease    meningoencephalitis    retinitis pigmentosa
    adult t-cell leukemia    hiv-1    brain cancer    retinitis
    cholera    t-cell leukemia    inflammatory bowel disease    lateral sclerosis
    atherosclerosis    myeloma    tonsillitis    sarcoma
    leukemia    hepatocellular carcinoma    thyroiditis    prostate cancer


    TNPO1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    3 Novoseek inferred disease relationships for TNPO1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hiv infections 13.3 2 9247020 (1), 10876908 (1)
    inflammation 0 1 11391951 (1)
    tumors 0 2 15005344 (1)


    Export disorders for TNPO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNPO1 gene, integrated from 10 sources (see all 166):
    (articles sorted by number of sources associating them with TNPO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Karyopherin beta2 mediates nuclear import of a mRNA binding protein. (PubMed id 9144189)1, 2, 3, 9 Bonifaci N.... Blobel G. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. A novel receptor-mediated nuclear protein import pathway. (PubMed id 8808633)1, 2, 3 Pollard V.W....Dreyfuss G. (Cell 1996)
    3. RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1. (PubMed id 19124606)1, 2, 9 Fritz J....Jantsch M.F. (Mol. Cell. Biol. 2009)
    4. Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp. (PubMed id 10353245)1, 2, 9 Chook Y.M. and Blobel G. (Nature 1999)
    5. Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1. (PubMed id 16704975)1, 2 Arnold M.... Kehlenbach R.H. (J. Biol. Chem. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin. (PubMed id 11682607)1, 2 Dean K.A.... Fried H.M. (J. Cell Sci. 2001)
    9. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. (PubMed id 9687515)1, 2 Jaekel S. and Goerlich D. (EMBO J. 1998)
    10. Transportin: nuclear transport receptor of a novel nuclear protein import pathway. (PubMed id 8986607)1, 2 Nakielny S....Dreyfuss G. (Exp. Cell Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3842 HGNC: 6401 AceView: TNPO1 Ensembl:ENSG00000083312 euGenes: HUgn3842
    ECgene: TNPO1 H-InvDB: TNPO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNPO1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNPO1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNPO1 gene:
    Search GeneIP for patents involving TNPO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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