TNPO1 Gene
protein-coding GIFtS: 59
GCID: GC05P072148
|
|
transportin 1(Previous name: karyopherin (importin) beta 2 )
(Previous symbol: KPNB2)
| |
Aliases
for TNPO1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transportin 11 2 | | Importin Beta-22 3 | | KPNB21 2 3 5 | | Karyopherin Beta-22 3 | | MIP11 2 3 5 | | M9 Region Interaction Protein2 3 | | MIP1 2 3 | | Importin 22 | | TRN1 2 3 | | Importin Beta 22 | | IPO21 2 | | Transportin-11 | | Karyopherin (Importin) Beta 21 2 | | |
Export aliases for TNPO1 gene to outside databasesPrevious GC identifers: GC05P072196 GC05P067317 |
Summaries
for TNPO1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TNPO1:
This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localizationsignals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alphasubunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins.Alternate splicing of this gene results in two transcript variants encoding different proteins. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: TNPO1_HUMAN, Q92973Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclearlocalization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to thenuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through thepore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin,the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTPhydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distributionof the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear importof M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins(hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export.Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding(BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in aRanGTP-dependent manner
Gene Wiki entry for TNPO1 (Transportin 1)
|
Genomic Views
for TNPO1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TNPO1 gene promoter:
GR Sox5 SREBP-1c GR-beta FOXD3 AP-4 SREBP-1b YY1 SREBP-1a GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for TNPO1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNPO1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q13.2 Ensembl cytogenetic band: 5q13.2 HGNC cytogenetic band: 5q13.1TNPO1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P072148: view genomic region
(about GC identifiers)
Start:
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72,112,139 bp from pter |
End:
|
72,212,560 bp from pter |
Size:
|
100,422 bases |
Orientation:
|
plus strand |
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Proteins
for TNPO1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TNPO1_HUMAN, Q92973 (See
protein sequence)Recommended Name: Transportin-1 Size: 898 amino acids; 102355 Da
Subunit: Binds HNRPA1, HNRPA2, HNRPDL, RPL23A, RPS7, RPL5, RAN and SRP19. Interacts with H2A, H2B, H3 and H4 histones.Binds to HIV-1 Rev. Interacts with isoform 5 of ADAR/ADAR1 (via DRBM 3 domain). Interacts with SNAI1 (via zincfingers); the interaction mediates SNAI1 nuclear import. Interacts with SNAI2 (via zinc fingers)
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAC50723.1; Type=Erroneous initiation; Sequence=AAH40340.1; Type=Erroneous initiation;
6/11 PDB 3D structures from  and Proteopedia  for TNPO1 (see all 11):1QBK (3D)
2H4M (3D)
2OT8 (3D)
2QMR (3D)
2Z5J (3D)
2Z5K (3D)
Secondary accessions: B4DVC6 Q92957 Q92975Alternative splicing: 3 isoforms: Q92973-1 Q92973-2 Q92973-3 Explore the universe of human proteins at neXtProt for TNPO1: NX_Q92973
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92973
TNPO1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_002261.3 NP_694858.1
ENSEMBL proteins: ENSP00000336712 ENSP00000430312 ENSP00000428899 ENSP00000379635 ENSP00000425118 ENSP00000428507 ENSP00000398524 ENSP00000415164 Reactome Protein details: Q92973
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
TNPO1 for ontologies About GeneDecksing
TNPO1 Antibody Products:
Assay Products for TNPO1: |
Protein
Domains /
Families
for TNPO1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TNPO1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92973ProtoNet protein and cluster: Q92973 3 Blocks protein families: IPB000225 Armadillo repeat IPB000357 HEAT repeat IPB001494 Importin-beta
UniProtKB/Swiss-Prot: TNPO1_HUMAN, Q92973Similarity: Belongs to the importin beta familySimilarity: Contains 8 HEAT repeatsSimilarity: Contains 1 importin N-terminal domain |
Function
for TNPO1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TNPO1_HUMAN, Q92973Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclearlocalization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to thenuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through thepore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin,the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTPhydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distributionof the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear importof M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins(hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export.Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding(BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in aRanGTP-dependent manner
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNPO1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNPO1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TNPO1 (NM_002270) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNPO1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNPO1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNPO1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TNPO1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TNPO1:
|
Pathways & Interactions
for TNPO1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell cycle_Spindle assembly and chromosome separation | | | 2 | Metabolism of mRNA | | | 3 | Development_TGF-beta receptor signaling | | | 4 | Ubiquitinated Orc1 is degraded by the proteasome | | | 5 | Destabilization of mRNA by Tristetraprolin (TTP) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for TNPO1
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNPO1
2  GeneGo (Thomson Reuters) Pathways for TNPO1
5 
Reactome Pathways for TNPO1
TNPO1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNPO1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/635 Interacting proteins for TNPO1 (Q929731, 2, 3 ENSP000003367124) via UniProtKB, MINT, STRING, and/or I2D (see all 635)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| NXF1 | Q9UBU92, 3, ENSP000002941724 | MINT-15485 MINT-15486 I2D:
score=3 STRING: ENSP00000294172 | | GCN1L1 | Q926162, 3, ENSP000003006484 | MINT-7947479 I2D:
score=4 STRING: ENSP00000300648 | | ELAVL1 | Q157172, 3, ENSP000003852694 | MINT-7947479 I2D:
score=1 STRING: ENSP00000385269 | | GRB2 | P629931, 3, ENSP000003390074 | EBI-1965561,EBI-401755 I2D:
score=1 STRING: ENSP00000339007 | | PSMC6 | P623332, 3 | MINT-7947479 I2D:
score=3 |
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
TNPO1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TNPO1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TNPO1 for compounds About GeneDecksing
 Browse Tocris compounds for TNPO1
1 HMDB Compound for TNPO1 About this table
4 Novoseek chemical compound relationships for TNPO1 gene About this table
Search CenterWatch for drugs/clinical trials and news about TNPO1
|
Transcripts
for TNPO1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TNPO1 gene (2 alternative transcripts): NM_002270.3 NM_153188.2 Unigene Cluster for TNPO1: Transportin 1 Hs.482497 [show with all ESTs]Unigene Representative Sequence: NM_00227017 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000337273(uc011csi.1 uc003kck.4 uc003kci.4 uc003kcg.4)
ENST00000515483 ENST00000520850 ENST00000523768 ENST00000396346 ENST00000518279
ENST00000513944 ENST00000506351 ENST00000509030 ENST00000511754 ENST00000506528
ENST00000508762 ENST00000505082 ENST00000519220 ENST00000503084 ENST00000454282(uc011csj.1)
ENST00000447967
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNPO1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNPO1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TNPO1 (NM_002270) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNPO1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNPO1 |
Additional cDNA sequence: AK055669.1 AK090518.1 AK124768.1 AK299671.1 AK301021.1 AK308177.1 AL049378.1 BC040340.1 U70322.1 U72069.1 U72395.1 24/38 DOTS entries (see all 38): DT.442028 DT.446733 DT.92443089 DT.97826902 DT.100794057 DT.91962001 DT.100694075 DT.120837566 DT.100746266 DT.120837612 DT.100778665 DT.95102393 DT.95181779 DT.120837683 DT.95181785 DT.100794062 DT.100794059 DT.100803960 DT.100805598 DT.120837684 DT.121212872 DT.91853984 DT.92443090 DT.95181783 24/603 AceView cDNA sequences (see all 603): AI014605 AA931074 AK124768 CR592982 AW167241 AA134756 C00263 BQ417419 BE302008 CB044442 BM830536 BU689354 BF592834 AV651208 AI765943 AA451704 H91653 AA481124 AI867579 CD721920 AA974727 AA442609 BX097739 AW001703
GeneLoc Exon Structure
|
Expression
for TNPO1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TNPO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TNPO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNPO1
SOURCE GeneReport for Unigene cluster: Hs.482497
SABiosciences Custom PCR Arrays for TNPO1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNPO1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNPO1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNPO1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNPO1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNPO1 |
Orthologs
for TNPO1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TNPO1 gene from 9/33 species (see all 33) About this table
ENSEMBL Gene Tree for TNPO1 (if available)
TreeFam Gene Tree for TNPO1 (if available) |
Paralogs
for TNPO1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TNPO1 gene
- TNPO22
2 SIMAP similar genes for TNPO1 using alignment to 5 protein entries: TNPO1_HUMAN (see all proteins):TNPO2 variant protein TNPO2
TNPO1 for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for TNPO1
PGOHUM00000238863 PGOHUM00000262947 PGOHUM00000262948 PGOHUM00000256819 PGOHUM00000256820
|
Genomic Variants
for TNPO1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TNPO1 (72112139 - 72212560 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TNPO1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNPO1 |
|
Disorders
/ Diseases
for TNPO1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TNPO1 for disorders About GeneDecksing
OMIM gene information: 602901
OMIM disorders: --
20/21  diseases for TNPO1 (see all 21): About MalaCardsretinitis pigmentosa-2 retinitis pigmentosa legionnaires' disease inflammatory bowel disease
adult t-cell leukemia meningoencephalitis leukemia/lymphoma lateral sclerosis
t-cell leukemia retinitis cholera hematopoiesis
hepatocellular carcinoma leukemia atherosclerosis myeloma
sarcoma immunodeficiency carcinoma malaria
3 Novoseek disease relationships for TNPO1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hiv infections |
13.3 |
2 |
9247020 (1), 10876908 (1) |
| inflammation |
0 |
1 |
11391951 (1) |
| tumors |
0 |
2 |
15005344 (1) |
Export disorders for TNPO1 gene to outside databases
|
Publications
for TNPO1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TNPO1 gene, integrated from 9 sources (see all 147):
(articles sorted by number of sources associating them with TNPO1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Karyopherin beta2 mediates nuclear import of a mRNA binding protein. (PubMed id 9144189)1, 2, 3, 9 Bonifaci N....Blobel G. (1997)
- A novel receptor-mediated nuclear protein import pathway. (PubMed id 8808633)1, 2, 3 Pollard V.W....Dreyfuss G. (1996)
- RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1. (PubMed id 19124606)1, 2, 9 Fritz J....Jantsch M.F. (2009)
- Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp. (PubMed id 10353245)1, 2, 9 Chook Y.M. and Blobel G. (1999)
- Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1. (PubMed id 16704975)1, 2 Arnold M.... Kehlenbach R.H. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin. (PubMed id 11682607)1, 2 Dean K.A.... Fried H.M. (2001)
- Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. (PubMed id 9687515)1, 2 Jaekel S. and Goerlich D. (1998)
- Transportin: nuclear transport receptor of a novel nuclear protein import pathway. (PubMed id 8986607)1, 2 Nakielny S....Dreyfuss G. (1996)
|
External Searches for TNPO1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TNPO1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TNPO1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TNPO1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TNPO1 gene:
Search GeneIP for patents involving TNPO1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TNPO1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TNPO1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNPO1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNPO1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TNPO1 | | OriGene 3'-UTR Clone for TNPO1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNPO1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNPO1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TNPO1 | | OriGene Custom Protein Services for TNPO1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TNPO1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNPO1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNPO1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNPO1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNPO1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNPO1 |
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| | | | Search Tocris compounds for TNPO1 |
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 | | | TNPO1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNPO1 |
|  |  |  | | | | ThermoFisher Antibody for TNPO1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNPO1 |
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