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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNPO1 Gene

protein-coding   GIFtS: 62
GCID: GC05P072148

Transportin 1

(Previous name: karyopherin (importin) beta 2)
(Previous symbol: KPNB2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transportin 11 2     MIP2 3
KPNB21 2 3 5     TRN2 3
MIP12 3 5     M9 Region Interaction Protein2 3
Karyopherin (Importin) Beta 21 2     IPO22
Importin 21 2     Importin Beta 22
Importin Beta-22 3     transportin-12
Karyopherin Beta-22 3     

External Ids:    HGNC: 64011   Entrez Gene: 38422   Ensembl: ENSG000000833127   OMIM: 6029015   UniProtKB: Q929733   

Export aliases for TNPO1 gene to outside databases

Previous GC identifers: GC05P072196 GC05P067317


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNPO1 Gene:
This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization
signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha
subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at
nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TNPO1 Gene: 
TNPO1 (transportin 1) is a protein-coding gene. Diseases associated with TNPO1 include retinitis pigmentosa-2, and meningoencephalitis, and among its related super-pathways are Metabolism of RNA and Development TGF-beta receptor signaling. GO annotations related to this gene include protein transporter activity and nuclear localization sequence binding. An important paralog of this gene is TNPO2.

UniProtKB/Swiss-Prot: TNPO1_HUMAN, Q92973
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear
localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex
to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds
to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by
an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By
similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of
the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also
to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and
RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of
H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of
HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner

Gene Wiki entry for TNPO1 (Transportin 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNPO1 gene promoter:
         GR   Sox5   SREBP-1c   GR-beta   FOXD3   AP-4   SREBP-1b   YY1   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNPO1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNPO1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNPO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.2   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13.1

TNPO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNPO1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P072148:  view genomic region     (about GC identifiers)

Start:
72,112,139 bp from pter      End:
72,212,560 bp from pter
Size:
100,422 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNPO1_HUMAN, Q92973 (See protein sequence)
Recommended Name: Transportin-1  
Size: 898 amino acids; 102355 Da
Subunit: Binds HNRPA1, HNRPA2, HNRPDL, RPL23A, RPS7, RPL5, RAN and SRP19. Interacts with H2A, H2B, H3 and H4
histones. Binds to HIV-1 Rev. Interacts with isoform 5 of ADAR/ADAR1 (via DRBM 3 domain). Interacts with SNAI1
(via zinc fingers); the interaction mediates SNAI1 nuclear import. Interacts with SNAI2 (via zinc fingers)
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAC50723.1; Type=Erroneous initiation; Sequence=AAH40340.1; Type=Erroneous initiation;
6/11 PDB 3D structures from and Proteopedia for TNPO1 (see all 11):
1QBK (3D)        2H4M (3D)        2OT8 (3D)        2QMR (3D)        2Z5J (3D)        2Z5K (3D)    
Secondary accessions: B4DVC6 Q92957 Q92975
Alternative splicing: 3 isoforms:  Q92973-1   Q92973-2   Q92973-3   

Explore the universe of human proteins at neXtProt for TNPO1: NX_Q92973

Explore proteomics data for TNPO1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92973

  • TNPO1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNPO1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002261.3  NP_694858.1  

    ENSEMBL proteins: 
     ENSP00000336712   ENSP00000430312   ENSP00000428899   ENSP00000425118   ENSP00000474059  
     ENSP00000398524   ENSP00000415164  
    Reactome Protein details: Q92973
    Human Recombinant Protein Products for TNPO1: 
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    Novus Biologicals TNPO1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNPO1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005643nuclear pore ----
    GO:0005737cytoplasm TAS9144189
    GO:0005829cytosol TAS--

    TNPO1 for ontologies           About GeneDecksing



    TNPO1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for TNPO1 

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    Cloud-Clone Corp. ELISAs for TNPO1 
    Cloud-Clone Corp. CLIAs for TNPO1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IPO: Importins

    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q92973

    ProtoNet protein and cluster: Q92973

    3 Blocks protein domains:
    IPB000225 Armadillo repeat
    IPB000357 HEAT repeat
    IPB001494 Importin-beta


    UniProtKB/Swiss-Prot: TNPO1_HUMAN, Q92973
    Similarity: Belongs to the importin beta family
    Similarity: Contains 8 HEAT repeats
    Similarity: Contains 1 importin N-terminal domain


    TNPO1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNPO1_HUMAN, Q92973
    Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear
    localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex
    to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
    through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds
    to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
    cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by
    an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By
    similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of
    the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also
    to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and
    RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of
    H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of
    HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI10353245
    GO:0008139nuclear localization sequence binding TAS8808633
    GO:0008536Ran GTPase binding IEA--
    GO:0008565protein transporter activity ----
         
    TNPO1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNPO1:
     Cell division defect  Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNPO1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNPO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNPO1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNPO1 

    miRNA
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    miRTarBase miRNAs that target TNPO1:
    hsa-mir-210 (MIRT003172)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNPO1
    8/172 QIAGEN miScript miRNA Assays for microRNAs that regulate TNPO1 (see all 172):
    hsa-miR-411* hsa-miR-640 hsa-miR-3938 hsa-miR-128 hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-3622b-3p hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNPO1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNPO1 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    2Development TGF-beta receptor signaling
    Development TGF-beta receptor signaling0.96
    3Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation0.94
    4Destabilization of mRNA by Tristetraprolin (TTP)
    Destabilization of mRNA by Tristetraprolin (TTP)0.79
    5CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.63

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for TNPO1
        Cell cycle Spindle assembly and chromosome separation
    Development TGF-beta receptor signaling

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNPO1
        Ran Pathway
    SREBP Proteolysis
    NFAT in Immune Response

    2 GeneGo (Thomson Reuters) Pathways for TNPO1
        Cell cycle Spindle assembly and chromosome separation
    Development TGF-beta receptor signaling

    5        Reactome Pathways for TNPO1
        Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
    Destabilization of mRNA by Tristetraprolin (TTP)
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression



    TNPO1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNPO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/662 Interacting proteins for TNPO1 (Q929731, 2, 3 ENSP000003367124) via UniProtKB, MINT, STRING, and/or I2D (see all 662)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NXF1Q9UBU92, 3, ENSP000002941724MINT-15485 MINT-15486 I2D: score=3 STRING: ENSP00000294172
    GCN1L1Q926162, 3, ENSP000003006484MINT-7947479 I2D: score=4 STRING: ENSP00000300648
    ELAVL1Q157172, 3, ENSP000003852694MINT-7947479 I2D: score=1 STRING: ENSP00000385269
    GRB2P629931, 3, ENSP000003390074EBI-286693,EBI-401755 I2D: score=1 STRING: ENSP00000339007
    PSMC6P623332, 3MINT-7947479 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation TAS9144189
    GO:0006886intracellular protein transport ----
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--

    TNPO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNPO1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNPO1

    1 HMDB Compound for TNPO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    4 Novoseek inferred chemical compound relationships for TNPO1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mcp 1 74.8 1 7589134 (1)
    rantes 68.4 10 9247020 (1), 11391951 (1), 19397398 (1), 10876908 (1) (see all 9)
    gdp 26.4 1 10353245 (1)
    calcium 0 1 9702779 (1)

    Search CenterWatch for drugs/clinical trials and news about TNPO1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNPO1 gene (2 alternative transcripts): 
    NM_002270.3  NM_153188.2  

    Unigene Cluster for TNPO1:

    Transportin 1
    Hs.482497  [show with all ESTs]
    Unigene Representative Sequence: NM_002270
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337273(uc011csi.1 uc003kck.4 uc003kci.4 uc003kcg.4)
    ENST00000515483 ENST00000520850 ENST00000523768 ENST00000518279 ENST00000513944
    ENST00000506351 ENST00000509030 ENST00000511754 ENST00000506528 ENST00000508762
    ENST00000505082 ENST00000605210 ENST00000503084 ENST00000454282(uc011csj.1)
    ENST00000447967
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-411* hsa-miR-640 hsa-miR-3938 hsa-miR-128 hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-3622b-3p hsa-miR-298
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    Additional mRNA sequence: 

    AK055669.1 AK090518.1 AK124768.1 AK299671.1 AK301021.1 AK308177.1 AL049378.1 BC040340.1 
    U70322.1 U72069.1 U72395.1 

    24/37 DOTS entries (see all 37):

    DT.442028  DT.446733  DT.92443089  DT.97826902  DT.100794057  DT.91962001  DT.100694075  DT.100746266 
    DT.120837612  DT.120837566  DT.100778665  DT.95102393  DT.95181779  DT.120837683  DT.95181785  DT.100794062 
    DT.100794059  DT.100803960  DT.100805598  DT.120837684  DT.121212872  DT.91853984  DT.92443090  DT.95181783 

    24/603 AceView cDNA sequences (see all 603):

    BQ186448 AI983108 N32321 BX097739 BU689354 H91653 BF476146 AL603416 
    BM845934 AL043497 AU123781 AA370302 BU069048 AI524543 BI491566 AL700634 
    AW003602 AV651208 AW167241 AA453318 AL703042 AA811828 BF149183 CR592982 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNPO1 expression in normal human tissues (normalized intensities)      TNPO1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TNPO1 Expression
    About this image


    TNPO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             superior temporal gyrus   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See TNPO1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNPO1

    SOURCE GeneReport for Unigene cluster: Hs.482497
        SABiosciences Custom PCR Arrays for TNPO1
    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TNPO1 gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnpo11 , 5 transportin 11, 5 90.79(n)1
    99.67(a)1
      13 (52.24 cM)5
    2387991  NM_178716.31  NP_848831.21 
     988390195 
    chicken
    (Gallus gallus)
    Aves TNPO11 transportin 1 87(n)
    96.74(a)
      427218  XM_424806.3  XP_424806.2 
    lizard
    (Anolis carolinensis)
    Reptilia TNPO16
    Uncharacterized protein
    97(a)
    1 ↔ 1
    2(16274254-16307859)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.14932 Xenopus laevis transportin mRNA, partial cds 86.68(n)    AF059614.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tnpo11 transportin 1 78.16(n)
    92.7(a)
      562607  XM_685987.2  XP_691079.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trn1 Transportin 66.06(n)
    74.69(a)
      38721  NM_058020.3  NP_477368.1 
    worm
    (Caenorhabditis elegans)
    Secernentea imb-21 Protein IMB-2 55.25(n)
    52.74(a)
      175094  NM_064586.2  NP_496987.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KAP104(YBR017C)4 Transportin or cytosolic karyopherin beta 2; functions more   --   2(273703-270947) 852305  NP_009573.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TRN11 transportin 1 52.56(n)
    46.59(a)
      816198  NM_127248.4  NP_179287.3 
    rice
    (Oryza sativa)
    Liliopsida Os04g06915001 hypothetical protein 53.06(n)
    49.56(a)
      4337505  NM_001060894.2  NP_001054359.2 


    ENSEMBL Gene Tree for TNPO1 (if available)
    TreeFam Gene Tree for TNPO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNPO1 gene
    TNPO22  
    2 SIMAP similar genes for TNPO1 using alignment to 3 protein entries:     TNPO1_HUMAN (see all proteins):
    TNPO2    TNPO2 variant protein

    TNPO1 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for TNPO1
    PGOHUM00000238863 PGOHUM00000262947 PGOHUM00000262948 PGOHUM00000256819 PGOHUM00000256820


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1818 SNPs in TNPO1 are shown (see all 1818)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0144554
    ----see VAR_0144552 D E mis40--------
    rs1830403711,2
    --72110507(+) TAAAGA/GGAAAA 1 -- us2k10--------
    rs47040401,2
    C,F,A,H--72110515(+) AAATAC/TTACTG 1 -- us2k17Minor allele frequency- T:0.41NA WA EA 366
    rs117415771,2
    C,F,H--72110573(+) CCATGT/CTAATA 1 -- us2k1 tfbs36Minor allele frequency- C:0.17NA WA CSA EA 364
    rs1448388501,2
    C--72110645(+) AAAAAA/GGCTAC 1 -- us2k10--------
    rs1387792411,2
    C--72110746(+) TAATCC/TCAATT 1 -- us2k10--------
    rs1863016761,2
    C--72110780(+) TTTTTC/TCTTTC 1 -- us2k10--------
    rs1417235521,2
    --72111074(+) AAATAC/TACTTT 1 -- us2k10--------
    rs1897920081,2
    --72111110(+) AACTAA/CCATTC 1 -- us2k10--------
    rs342797101,2
    C--72111161(+) TATTTG/-GGGGG 1 -- us2k11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for TNPO1 (72112139 - 72212560 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TNPO1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2730296CNV Deletion23290073
    esv2730297CNV Deletion23290073
    dgv6181n71CNV Loss21882294
    nsv830343CNV Loss17160897
    dgv6180n71CNV Loss21882294
    nsv882180CNV Loss21882294
    nsv525479CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602901    OMIM disorders: --

    16 diseases for TNPO1:    About MalaCards
    retinitis pigmentosa-2    meningoencephalitis    legionnaires' disease    hiv type 1
    retinitis pigmentosa    adult t-cell leukemia    cholera    retinitis
    t-cell leukemia    lateral sclerosis    inflammatory bowel disease    atherosclerosis
    myeloma    sarcoma    leukemia    hepatocellular carcinoma


    TNPO1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TNPO1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hiv infections 13.3 2 9247020 (1), 10876908 (1)
    inflammation 0 1 11391951 (1)
    tumors 0 2 15005344 (1)


    Export disorders for TNPO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNPO1 gene, integrated from 9 sources (see all 162):
    (articles sorted by number of sources associating them with TNPO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Karyopherin beta2 mediates nuclear import of a mRNA binding protein. (PubMed id 9144189)1, 2, 3, 9 Bonifaci N....Blobel G. (1997)
    2. A novel receptor-mediated nuclear protein import pathway. (PubMed id 8808633)1, 2, 3 Pollard V.W....Dreyfuss G. (1996)
    3. RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1. (PubMed id 19124606)1, 2, 9 Fritz J....Jantsch M.F. (2009)
    4. Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp. (PubMed id 10353245)1, 2, 9 Chook Y.M. and Blobel G. (1999)
    5. Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1. (PubMed id 16704975)1, 2 Arnold M.... Kehlenbach R.H. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin. (PubMed id 11682607)1, 2 Dean K.A.... Fried H.M. (2001)
    9. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. (PubMed id 9687515)1, 2 Jaekel S. and Goerlich D. (1998)
    10. Transportin: nuclear transport receptor of a novel nuclear protein import pathway. (PubMed id 8986607)1, 2 Nakielny S....Dreyfuss G. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3842 HGNC: 6401 AceView: TNPO1 Ensembl:ENSG00000083312 euGenes: HUgn3842
    ECgene: TNPO1 H-InvDB: TNPO1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNPO1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNPO1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNPO1 gene:
    Search GeneIP for patents involving TNPO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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