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Aliases for TNPO1 Gene

Aliases for TNPO1 Gene

  • Transportin 1 2 3
  • Karyopherin (Importin) Beta 2 2 3
  • M9 Region Interaction Protein 3 4
  • Karyopherin Beta-2 3 4
  • Importin Beta-2 3 4
  • Importin 2 2 3
  • KPNB2 3 4
  • MIP1 3 4
  • TRN 3 4
  • MIP 3 4
  • Importin Beta 2 3
  • IPO2 3

External Ids for TNPO1 Gene

Previous HGNC Symbols for TNPO1 Gene

  • KPNB2

Previous GeneCards Identifiers for TNPO1 Gene

  • GC05P072196
  • GC05P072148
  • GC05P067317

Summaries for TNPO1 Gene

Entrez Gene Summary for TNPO1 Gene

  • This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNPO1 Gene

TNPO1 (Transportin 1) is a Protein Coding gene. Diseases associated with TNPO1 include retinitis pigmentosa 2 and hiv-1. Among its related pathways are GPCR Pathway and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and Ran GTPase binding. An important paralog of this gene is TNPO2.

UniProtKB/Swiss-Prot for TNPO1 Gene

  • Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner.

Gene Wiki entry for TNPO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNPO1 Gene

Genomics for TNPO1 Gene

Regulatory Elements for TNPO1 Gene

Genomic Location for TNPO1 Gene

Chromosome:
5
Start:
72,816,312 bp from pter
End:
72,916,733 bp from pter
Size:
100,422 bases
Orientation:
Plus strand

Genomic View for TNPO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TNPO1 Gene

Proteins for TNPO1 Gene

  • Protein details for TNPO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92973-TNPO1_HUMAN
    Recommended name:
    Transportin-1
    Protein Accession:
    Q92973
    Secondary Accessions:
    • B4DVC6
    • Q92957
    • Q92975

    Protein attributes for TNPO1 Gene

    Size:
    898 amino acids
    Molecular mass:
    102355 Da
    Quaternary structure:
    • Binds HNRPA1, HNRPA2, HNRNPDL, RPL23A, RPS7, RPL5, RAN and SRP19. Interacts with H2A, H2B, H3 and H4 histones. Binds to HIV-1 Rev. Interacts with isoform 5 of ADAR/ADAR1 (via DRBM 3 domain). Interacts with SNAI1 (via zinc fingers); the interaction mediates SNAI1 nuclear import. Interacts with SNAI2 (via zinc fingers).
    SequenceCaution:
    • Sequence=AAC50723.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH40340.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNPO1 Gene

    Alternative splice isoforms for TNPO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNPO1 Gene

Proteomics data for TNPO1 Gene at MOPED

Post-translational modifications for TNPO1 Gene

  • Ubiquitination at Lys 85, Lys 192, and Lys 863
  • Modification sites at PhosphoSitePlus

Other Protein References for TNPO1 Gene

Antibody Products

No data available for DME Specific Peptides for TNPO1 Gene

Domains & Families for TNPO1 Gene

Gene Families for TNPO1 Gene

Protein Domains for TNPO1 Gene

Suggested Antigen Peptide Sequences for TNPO1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92973

UniProtKB/Swiss-Prot:

TNPO1_HUMAN :
  • Contains 1 importin N-terminal domain.
  • Belongs to the importin beta family. Importin beta-2 subfamily.
  • Contains 20 HEAT repeats.
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the importin beta family. Importin beta-2 subfamily.
Similarity:
  • Contains 20 HEAT repeats.
genes like me logo Genes that share domains with TNPO1: view

Function for TNPO1 Gene

Molecular function for TNPO1 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner.

Gene Ontology (GO) - Molecular Function for TNPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 10353245
GO:0008139 nuclear localization sequence binding TAS 8808633
GO:0008536 Ran GTPase binding IEA --
GO:0008565 protein transporter activity IBA --
genes like me logo Genes that share ontologies with TNPO1: view

Phenotypes for TNPO1 Gene

GenomeRNAi human phenotypes for TNPO1:
genes like me logo Genes that share phenotypes with TNPO1: view

miRNA for TNPO1 Gene

miRTarBase miRNAs that target TNPO1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNPO1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TNPO1 Gene

Localization for TNPO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNPO1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNPO1 Gene COMPARTMENTS Subcellular localization image for TNPO1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for TNPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus TAS 9144189
GO:0005737 cytoplasm TAS 9144189
GO:0005829 cytosol TAS --
GO:0031965 nuclear membrane IBA --
genes like me logo Genes that share ontologies with TNPO1: view

Pathways & Interactions for TNPO1 Gene

genes like me logo Genes that share pathways with TNPO1: view

Gene Ontology (GO) - Biological Process for TNPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000059 protein import into nucleus, docking IBA --
GO:0000060 protein import into nucleus, translocation TAS 9144189
GO:0006607 NLS-bearing protein import into nucleus IBA --
GO:0006610 ribosomal protein import into nucleus IBA --
GO:0006886 intracellular protein transport --
genes like me logo Genes that share ontologies with TNPO1: view

No data available for SIGNOR curated interactions for TNPO1 Gene

Drugs & Compounds for TNPO1 Gene

(2) Drugs for TNPO1 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
Calcium Nutra 0

(3) Additional Compounds for TNPO1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
gdp
mcp 1
RANTES
genes like me logo Genes that share compounds with TNPO1: view

Transcripts for TNPO1 Gene

Unigene Clusters for TNPO1 Gene

Transportin 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNPO1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNPO1 Gene

No ASD Table

Relevant External Links for TNPO1 Gene

GeneLoc Exon Structure for
TNPO1
ECgene alternative splicing isoforms for
TNPO1

Expression for TNPO1 Gene

mRNA expression in normal human tissues for TNPO1 Gene

Protein differential expression in normal tissues from HIPED for TNPO1 Gene

This gene is overexpressed in Bone (52.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNPO1 Gene



SOURCE GeneReport for Unigene cluster for TNPO1 Gene Hs.482497

genes like me logo Genes that share expression patterns with TNPO1: view

Protein tissue co-expression partners for TNPO1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TNPO1 Gene

Orthologs for TNPO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TNPO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TNPO1 35
  • 95.36 (n)
  • 99.78 (a)
TNPO1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNPO1 35
  • 95.19 (n)
  • 99.53 (a)
TNPO1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnpo1 35
  • 90.79 (n)
  • 99.67 (a)
Tnpo1 16
Tnpo1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNPO1 35
  • 99.81 (n)
  • 100 (a)
TNPO1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnpo1 35
  • 90.56 (n)
  • 99.44 (a)
oppossum
(Monodelphis domestica)
Mammalia TNPO1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNPO1 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNPO1 35
  • 86.98 (n)
  • 96.54 (a)
TNPO1 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNPO1 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnpo1 35
  • 83.26 (n)
  • 95.39 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1493 35
zebrafish
(Danio rerio)
Actinopterygii tnpo1 35
  • 77.94 (n)
  • 92.36 (a)
tnpo1 36
  • 92 (a)
OneToMany
TNPO1 (2 of 2) 36
  • 80 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005892 35
  • 65.2 (n)
  • 75.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta Trn 35
  • 66.03 (n)
  • 74.35 (a)
CG8219 36
  • 60 (a)
ManyToMany
Trn 36
  • 74 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea imb-2 35
  • 55.25 (n)
  • 52.74 (a)
imb-2 36
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAP104 36
  • 32 (a)
OneToMany
KAP104 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TRN1 35
  • 52.51 (n)
  • 46.3 (a)
rice
(Oryza sativa)
Liliopsida Os04g0691500 35
  • 53.06 (n)
  • 49.56 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9387 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03690 35
  • 48.21 (n)
  • 39.11 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes kap104 35
  • 52.71 (n)
  • 46.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5618 36
  • 72 (a)
OneToMany
Species with no ortholog for TNPO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNPO1 Gene

ENSEMBL:
Gene Tree for TNPO1 (if available)
TreeFam:
Gene Tree for TNPO1 (if available)

Paralogs for TNPO1 Gene

Paralogs for TNPO1 Gene

(2) SIMAP similar genes for TNPO1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TNPO1: view

Variants for TNPO1 Gene

Sequence variations from dbSNP and Humsavar for TNPO1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_014455 -

Structural Variations from Database of Genomic Variants (DGV) for TNPO1 Gene

Variant ID Type Subtype PubMed ID
nsv882180 CNV Loss 21882294
nsv525479 CNV Loss 19592680
nsv830343 CNV Loss 17160897
dgv6180n71 CNV Loss 21882294
dgv6181n71 CNV Loss 21882294
esv2730296 CNV Deletion 23290073
esv2730297 CNV Deletion 23290073

Variation tolerance for TNPO1 Gene

Residual Variation Intolerance Score: 7.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNPO1 Gene

HapMap Linkage Disequilibrium report
TNPO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNPO1 Gene

Disorders for TNPO1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TNPO1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa 2
  • rp2
hiv-1
  • aids, slow progression to
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association
Search TNPO1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TNPO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNPO1
genes like me logo Genes that share disorders with TNPO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNPO1 Gene

Publications for TNPO1 Gene

  1. Karyopherin beta2 mediates nuclear import of a mRNA binding protein. (PMID: 9144189) Bonifaci N. … Blobel G. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 23 67
  2. Glucose-induced expression of MIP-1 genes requires O-GlcNAc transferase in monocytes. (PMID: 20206135) Chikanishi T. … Kato S. (Biochem. Biophys. Res. Commun. 2010) 23 67
  3. Apolipoprotein A-I mimetic 4F alters the function of human monocyte-derived macrophages. (PMID: 20219948) Smythies L.E. … Datta G. (Am. J. Physiol., Cell Physiol. 2010) 23 67
  4. A glycine-rich domain of hnRNP H/F promotes nucleocytoplasmic shuttling and nuclear import through an interaction with transportin 1. (PMID: 20308327) Van Dusen C.M. … McNally M.T. (Mol. Cell. Biol. 2010) 23 67
  5. Cellular chemotaxis induced by wear particles from joint replacements. (PMID: 20398931) Goodman S.B. … Ma T. (Biomaterials 2010) 23 67

Products for TNPO1 Gene

Sources for TNPO1 Gene

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