Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TNP2 Gene

Subcategory (RNA class) for TNP2 Gene

lncRNA

Aliases for TNP2 Gene

  • Transition Protein 2 2 3 5
  • Transition Protein 2 (During Histone To Protamine Replacement) 2 3
  • TP-2 3 4
  • TP2 3 4
  • Nuclear Transition Protein 2 3

External Ids for TNP2 Gene

ORGUL Members for TNP2 Gene

Previous GeneCards Identifiers for TNP2 Gene

  • GC16M011135
  • GC16M011513
  • GC16M011328
  • GC16M011269
  • GC16M011361
  • GC16M011280

Summaries for TNP2 Gene

GeneCards Summary for TNP2 Gene

TNP2 (Transition Protein 2) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with TNP2 include Male Infertility and Male Reproductive System Disease.

UniProtKB/Swiss-Prot for TNP2 Gene

  • In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.

Gene Wiki entry for TNP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNP2 Gene

Genomics for TNP2 Gene

Regulatory Elements for TNP2 Gene


Enhancers around TNP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNP2 Gene

Chromosome:
16
Start:
11,267,748 bp from pter
End:
11,269,533 bp from pter
Size:
1,786 bases
Orientation:
Minus strand

Genomic View for TNP2 Gene

Genes around TNP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNP2 Gene

Proteins for TNP2 Gene

  • Protein details for TNP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05952-STP2_HUMAN
    Recommended name:
    Nuclear transition protein 2
    Protein Accession:
    Q05952
    Secondary Accessions:
    • Q9NZB0

    Protein attributes for TNP2 Gene

    Size:
    138 amino acids
    Molecular mass:
    15641 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TNP2 Gene

Post-translational modifications for TNP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNP2 Gene

Domains & Families for TNP2 Gene

Protein Domains for TNP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TNP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q05952

UniProtKB/Swiss-Prot:

STP2_HUMAN :
  • Belongs to the nuclear transition protein 2 family.
Family:
  • Belongs to the nuclear transition protein 2 family.
genes like me logo Genes that share domains with TNP2: view

No data available for Gene Families for TNP2 Gene

Function for TNP2 Gene

Molecular function for TNP2 Gene

GENATLAS Biochemistry:
transition protein 2 (in haploid spermatogenic cells during transition histone-protamine)
UniProtKB/Swiss-Prot Function:
In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.

Gene Ontology (GO) - Molecular Function for TNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TNP2: view
genes like me logo Genes that share phenotypes with TNP2: view

Animal Model Products

miRNA for TNP2 Gene

miRTarBase miRNAs that target TNP2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNP2 Gene

Localization for TNP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNP2 Gene

Nucleus, nucleolus. Chromosome. Note=Nuclear import is ATP-dependent and nucleolar localization requires the protein to be phosphorylated. {ECO:0000250 UniProtKB:P11101}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNP2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0001673 male germ cell nucleus IBA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with TNP2: view

Pathways & Interactions for TNP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IBA --
GO:0007340 acrosome reaction IBA --
GO:0007341 penetration of zona pellucida IBA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TNP2: view

No data available for Pathways by source and SIGNOR curated interactions for TNP2 Gene

Drugs & Compounds for TNP2 Gene

(1) Drugs for TNP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TNP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNP2: view

Transcripts for TNP2 Gene

mRNA/cDNA for TNP2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNP2 Gene

Transition protein 2 (during histone to protamine replacement):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNP2 Gene

No ASD Table

Relevant External Links for TNP2 Gene

GeneLoc Exon Structure for
TNP2
ECgene alternative splicing isoforms for
TNP2

Expression for TNP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNP2 Gene

mRNA differential expression in normal tissues according to GTEx for TNP2 Gene

This gene is overexpressed in Testis (x52.5).

NURSA nuclear receptor signaling pathways regulating expression of TNP2 Gene:

TNP2

SOURCE GeneReport for Unigene cluster for TNP2 Gene:

Hs.513349

mRNA Expression by UniProt/SwissProt for TNP2 Gene:

Q05952-STP2_HUMAN
Tissue specificity: Expressed by spermatids (at protein level).
genes like me logo Genes that share expression patterns with TNP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TNP2 Gene

Orthologs for TNP2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TNP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNP2 34 35
  • 97.58 (n)
dog
(Canis familiaris)
Mammalia TNP2 34 35
  • 75.45 (n)
cow
(Bos Taurus)
Mammalia TNP2 34 35
  • 66.67 (n)
mouse
(Mus musculus)
Mammalia Tnp2 35
  • 44 (a)
OneToOne
Species where no ortholog for TNP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNP2 Gene

ENSEMBL:
Gene Tree for TNP2 (if available)
TreeFam:
Gene Tree for TNP2 (if available)

Paralogs for TNP2 Gene

No data available for Paralogs for TNP2 Gene

Variants for TNP2 Gene

Sequence variations from dbSNP and Humsavar for TNP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs112459327 -- 11,270,783(+) TGAGC(C/T)CAAGG intron-variant, upstream-variant-2KB
rs113200082 -- 11,267,616(+) CTGTC(A/G)TGTTC intron-variant, downstream-variant-500B
rs113362637 -- 11,270,817(+) AAGTG(A/C)TGGCA intron-variant, upstream-variant-2KB
rs113581941 -- 11,267,698(+) CACAC(A/C)CATGT intron-variant, downstream-variant-500B
rs114342107 -- 11,270,410(+) CTCTC(C/T)GCATG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TNP2 Gene

Variant ID Type Subtype PubMed ID
nsv571453 CNV loss 21841781
nsv525548 CNV loss 19592680
nsv1040428 CNV gain 25217958

Variation tolerance for TNP2 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.65; 78.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNP2 Gene

Disorders for TNP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TNP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
male infertility
  • infertility male
male reproductive system disease
  • genital diseases, male
- elite association - COSMIC cancer census association via MalaCards
Search TNP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TNP2

Genetic Association Database (GAD)
TNP2
Human Genome Epidemiology (HuGE) Navigator
TNP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNP2
genes like me logo Genes that share disorders with TNP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNP2 Gene

Publications for TNP2 Gene

  1. Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility. (PMID: 16989827) Aoki V.W. … Carrell D.T. (Fertil. Steril. 2006) 3 22 46 64
  2. Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations. (PMID: 16291974) Miyagawa Y. … Tanaka H. (J. Androl. 2005) 3 22 46 64
  3. Expression of mRNA and protein of nucleoproteins during human spermiogenesis. (PMID: 9809674) Steger K. … Bergmann M. (Mol. Hum. Reprod. 1998) 3 4 22 64
  4. Linkage of human spermatid-specific basic nuclear protein genes. Definition and evolution of the P1-->P2-->TP2 locus. (PMID: 8428967) Nelson J.E. … Krawetz S.A. (J. Biol. Chem. 1993) 3 4 22 64
  5. The genes for protamine 1 and 2 (PRM1 and PRM2) and transition protein 2 (TNP2) are closely linked in the mammalian genome. (PMID: 1395729) Engel W. … SchlA1ter G. (Cytogenet. Cell Genet. 1992) 2 3 22 64

Products for TNP2 Gene

Sources for TNP2 Gene

Content
Loading form....