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Aliases for TNP1 Gene

Aliases for TNP1 Gene

  • Transition Protein 1 (During Histone To Protamine Replacement) 2 3
  • STP-1 3 4
  • TP-1 3 4
  • TP1 3

External Ids for TNP1 Gene

Previous GeneCards Identifiers for TNP1 Gene

  • GC02M215821
  • GC02M216445
  • GC02M217688
  • GC02M217926
  • GC02M217549
  • GC02M217432
  • GC02M217724
  • GC02M209578

Summaries for TNP1 Gene

Entrez Gene Summary for TNP1 Gene

  • Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TNP1 Gene

TNP1 (Transition Protein 1 (During Histone To Protamine Replacement)) is a Protein Coding gene. Diseases associated with TNP1 include epididymo-orchitis and aggressive systemic mastocytosis. Among its related pathways are Transcription_CREM signaling in testis.

UniProtKB/Swiss-Prot for TNP1 Gene

  • In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins

Gene Wiki entry for TNP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNP1 Gene

Genomics for TNP1 Gene

Regulatory Elements for TNP1 Gene

Genomic Location for TNP1 Gene

Chromosome:
2
Start:
216,859,458 bp from pter
End:
216,860,064 bp from pter
Size:
607 bases
Orientation:
Minus strand

Genomic View for TNP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNP1 Gene

Proteins for TNP1 Gene

  • Protein details for TNP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09430-STP1_HUMAN
    Recommended name:
    Spermatid nuclear transition protein 1
    Protein Accession:
    P09430

    Protein attributes for TNP1 Gene

    Size:
    55 amino acids
    Molecular mass:
    6424 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TNP1 Gene

Proteomics data for TNP1 Gene at MOPED

Post-translational modifications for TNP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNP1 Gene

Domains & Families for TNP1 Gene

Protein Domains for TNP1 Gene

Suggested Antigen Peptide Sequences for TNP1 Gene

Graphical View of Domain Structure for InterPro Entry

P09430

UniProtKB/Swiss-Prot:

STP1_HUMAN :
  • Belongs to the nuclear transition protein 1 family.
Family:
  • Belongs to the nuclear transition protein 1 family.
genes like me logo Genes that share domains with TNP1: view

No data available for Gene Families for TNP1 Gene

Function for TNP1 Gene

Molecular function for TNP1 Gene

GENATLAS Biochemistry:
transition protein 1 (in haploid spermatogenic cells during transition histone-protamine)
UniProtKB/Swiss-Prot Function:
In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins

Gene Ontology (GO) - Molecular Function for TNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IMP 12743712
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TNP1: view
genes like me logo Genes that share phenotypes with TNP1: view

Animal Models for TNP1 Gene

MGI Knock Outs for TNP1:

Animal Model Products

miRNA for TNP1 Gene

miRTarBase miRNAs that target TNP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNP1 Gene

Localization for TNP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNP1 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNP1 Gene COMPARTMENTS Subcellular localization image for TNP1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IDA 12743712
GO:0001673 male germ cell nucleus IBA --
GO:0005634 nucleus --
genes like me logo Genes that share ontologies with TNP1: view

Pathways & Interactions for TNP1 Gene

genes like me logo Genes that share pathways with TNP1: view

Pathways by source for TNP1 Gene

1 GeneGo (Thomson Reuters) pathway for TNP1 Gene

Gene Ontology (GO) - Biological Process for TNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000012 single strand break repair IDA 12743712
GO:0006337 nucleosome disassembly IMP 10781074
GO:0006338 chromatin remodeling IDA 12743712
GO:0006342 chromatin silencing IEP 11315969
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with TNP1: view

No data available for SIGNOR curated interactions for TNP1 Gene

Drugs & Compounds for TNP1 Gene

(1) Drugs for TNP1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
serine Nutra 420

(3) Additional Compounds for TNP1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Gold
  • Au Gold powder
  • Auride
  • Aurum
  • Aurum Metallicum
  • Burnish gold
7440-57-5
Paraffin
protamine
genes like me logo Genes that share compounds with TNP1: view

Transcripts for TNP1 Gene

mRNA/cDNA for TNP1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(70) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNP1 Gene

Transition protein 1 (during histone to protamine replacement):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1:
SP2: -

Relevant External Links for TNP1 Gene

GeneLoc Exon Structure for
TNP1
ECgene alternative splicing isoforms for
TNP1

Expression for TNP1 Gene

mRNA expression in normal human tissues for TNP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNP1 Gene

This gene is overexpressed in Testis (x52.6).

SOURCE GeneReport for Unigene cluster for TNP1 Gene Hs.3017

mRNA Expression by UniProt/SwissProt for TNP1 Gene

P09430-STP1_HUMAN
Tissue specificity: Expressed by spermatids (at protein level).
genes like me logo Genes that share expression patterns with TNP1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TNP1 Gene

Orthologs for TNP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TNP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNP1 35
  • 98.79 (n)
  • 98.18 (a)
TNP1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnp1 16
Tnp1 36
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNP1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNP1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNP1 36
  • 74 (a)
OneToOne
Species with no ortholog for TNP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNP1 Gene

ENSEMBL:
Gene Tree for TNP1 (if available)
TreeFam:
Gene Tree for TNP1 (if available)

Paralogs for TNP1 Gene

No data available for Paralogs for TNP1 Gene

Variants for TNP1 Gene

Variation tolerance for TNP1 Gene

Residual Variation Intolerance Score: 57.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNP1 Gene

HapMap Linkage Disequilibrium report
TNP1
Human Gene Mutation Database (HGMD)
TNP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for TNP1 Gene

Disorders for TNP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TNP1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
epididymo-orchitis
aggressive systemic mastocytosis
  • asm
male infertility
  • infertility male
- elite association
Search TNP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TNP1

Genetic Association Database (GAD)
TNP1
Human Genome Epidemiology (HuGE) Navigator
TNP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNP1
genes like me logo Genes that share disorders with TNP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNP1 Gene

Publications for TNP1 Gene

  1. Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2. (PMID: 2249851) Luerssen H. … Engel W. (Genomics 1990) 2 23 67
  2. Involvement of importin-4 in the transport of transition protein 2 into the spermatid nucleus. (PMID: 17682055) Pradeepa M.M. … Rao M.R. (Mol. Cell. Biol. 2008) 23 67
  3. Spermiogenesis defects in human: detection of transition proteins in semen from some infertile men. (PMID: 18727729) Becker S. … Golan R. (Andrologia 2008) 23 67
  4. Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men. (PMID: 17852044) Jedrzejczak P. … Jagodzinski P.P. (Arch. Androl. 2007) 23 67
  5. The role of androgens in spermatogenesis. (PMID: 17566258) Komori S. … Koyama K. (Soc Reprod Fertil Suppl 2007) 23 67

Products for TNP1 Gene

Sources for TNP1 Gene

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