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Aliases for TNNT3 Gene

Aliases for TNNT3 Gene

  • Troponin T Type 3 (Skeletal, Fast) 2 3
  • Fast Skeletal Muscle Troponin T 3 4
  • Beta-TnTF 3 4
  • TNTF 3 4
  • FTnT 3 4
  • Troponin T, Fast Skeletal Muscle 3
  • Troponin T3, Skeletal, Fast 2
  • Troponin-T3, Skeletal, Fast 3
  • Troponin-T3 2
  • Beta TnTF 3
  • Skeletal 2
  • AMCD2B 6
  • DA2B 6
  • Fast 2
  • FSSV 6

External Ids for TNNT3 Gene

Previous GeneCards Identifiers for TNNT3 Gene

  • GC11M000837
  • GC11P002023
  • GC11P001900
  • GC11P001908
  • GC11P001898
  • GC11P001710

Summaries for TNNT3 Gene

Entrez Gene Summary for TNNT3 Gene

  • The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]

GeneCards Summary for TNNT3 Gene

TNNT3 (Troponin T Type 3 (Skeletal, Fast)) is a Protein Coding gene. Diseases associated with TNNT3 include tnnt3-related arthrogryposis multiplex congenita, distal, type 2b and arthrogryposis, distal, type 2b. Among its related pathways are Striated Muscle Contraction and Striated Muscle Contraction. GO annotations related to this gene include actin binding and tropomyosin binding. An important paralog of this gene is TNNT1.

UniProtKB/Swiss-Prot for TNNT3 Gene

  • Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity

Gene Wiki entry for TNNT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNNT3 Gene

Genomics for TNNT3 Gene

Regulatory Elements for TNNT3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNNT3 Gene

1,919,562 bp from pter
1,938,706 bp from pter
19,145 bases
Plus strand

Genomic View for TNNT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNNT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNNT3 Gene

Proteins for TNNT3 Gene

  • Protein details for TNNT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Troponin T, fast skeletal muscle
    Protein Accession:
    Secondary Accessions:
    • A8MQ76
    • A8MSW1
    • B3KPX3
    • B7WP64
    • B7ZL26
    • B7ZVV9
    • Q12975
    • Q12976
    • Q12977
    • Q12978
    • Q17RG9
    • Q6FH29
    • Q6N056
    • Q86TH6

    Protein attributes for TNNT3 Gene

    269 amino acids
    Molecular mass:
    31825 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH50446.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TNNT3 Gene

neXtProt entry for TNNT3 Gene

Proteomics data for TNNT3 Gene at MOPED

Post-translational modifications for TNNT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for TNNT3 Gene

Domains for TNNT3 Gene

Protein Domains for TNNT3 Gene


Suggested Antigen Peptide Sequences for TNNT3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the troponin T family.
  • Belongs to the troponin T family.
genes like me logo Genes that share domains with TNNT3: view

No data available for Gene Families for TNNT3 Gene

Function for TNNT3 Gene

Molecular function for TNNT3 Gene

GENATLAS Biochemistry:
troponin T3,component of the troponin complex forming the calcium-sensitive molecular switch that regulates striated muscle contraction in response to modifications in intracellular concentration,fast skeletal muscle,organized in pair with TNNI2,involved in the attachment of the complex to tropomyosin and troponin I,not imprinted in humans
UniProtKB/Swiss-Prot Function:
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity

Gene Ontology (GO) - Molecular Function for TNNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 contributes_to actin binding IDA 17194691
GO:0005523 tropomyosin binding IMP 8987992
GO:0030172 troponin C binding IPI 8987992
GO:0030899 contributes_to calcium-dependent ATPase activity IDA 8987992
GO:0031013 troponin I binding IPI 15507453
genes like me logo Genes that share ontologies with TNNT3: view
genes like me logo Genes that share phenotypes with TNNT3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TNNT3 Gene

Localization for TNNT3 Gene

Subcellular locations from

Jensen Localization Image for TNNT3 Gene COMPARTMENTS Subcellular localization image for TNNT3 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for TNNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005861 troponin complex IDA 17194691
genes like me logo Genes that share ontologies with TNNT3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TNNT3 Gene

Pathways for TNNT3 Gene

genes like me logo Genes that share pathways with TNNT3: view

Pathways by source for TNNT3 Gene

1 BioSystems pathway for TNNT3 Gene
2 Reactome pathways for TNNT3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for TNNT3 Gene

Gene Ontology (GO) - Biological Process for TNNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003009 skeletal muscle contraction IDA 17194691
GO:0006200 obsolete ATP catabolic process --
GO:0006937 regulation of muscle contraction --
GO:0006942 regulation of striated muscle contraction IDA 17194691
GO:0008152 metabolic process IDA 8987992
genes like me logo Genes that share ontologies with TNNT3: view

Drugs for TNNT3 Gene

(1) HMDB Compounds for TNNT3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with TNNT3: view

Transcripts for TNNT3 Gene

Unigene Clusters for TNNT3 Gene

Troponin T type 3 (skeletal, fast):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNNT3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNNT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1: - -
SP2: - -
SP3: -

Relevant External Links for TNNT3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNNT3 Gene

mRNA expression in normal human tissues for TNNT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNNT3 Gene

This gene is overexpressed in Muscle - Skeletal (48.7).

Protein differential expression in normal tissues for TNNT3 Gene

This gene is overexpressed in Tonsil (48.4), Esophagus (9.3), and Stomach (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNNT3 Gene

SOURCE GeneReport for Unigene cluster for TNNT3 Gene Hs.73454

mRNA Expression by UniProt/SwissProt for TNNT3 Gene

Tissue specificity: In fetal and adult fast skeletal muscles, with a higher level expression in fetal than in adult muscle
genes like me logo Genes that share expressions with TNNT3: view

Primer Products

In Situ Assay Products

No data available for Expression partners for TNNT3 Gene

Orthologs for TNNT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNNT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNNT3 35
  • 90.05 (n)
  • 95.48 (a)
TNNT3 36
  • 87 (a)
(Canis familiaris)
Mammalia TNNT3 35
  • 89.55 (n)
  • 95.91 (a)
TNNT3 36
  • 90 (a)
(Mus musculus)
Mammalia Tnnt3 35
  • 88.99 (n)
  • 95.93 (a)
Tnnt3 16
Tnnt3 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia TNNT3 36
  • 76 (a)
(Pan troglodytes)
Mammalia TNNT3 36
  • 91 (a)
(Gallus gallus)
Aves TNNT3 35
  • 75.95 (n)
  • 85.84 (a)
TNNT3 36
  • 69 (a)
(Anolis carolinensis)
Reptilia TNNT3 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75764 35
tnnt3 35
  • 76.21 (n)
  • 81.82 (a)
African clawed frog
(Xenopus laevis)
Amphibia tnnt3a-prov 35
(Danio rerio)
Actinopterygii -- 35
tnnt3b 35
  • 72.22 (n)
  • 72.86 (a)
tnnt3a 36
  • 65 (a)
tnnt3b 36
  • 53 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10451 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10162 36
  • 42 (a)
CSA.963 36
  • 45 (a)
Species with no ortholog for TNNT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNNT3 Gene

Gene Tree for TNNT3 (if available)
Gene Tree for TNNT3 (if available)

Paralogs for TNNT3 Gene

Paralogs for TNNT3 Gene

genes like me logo Genes that share paralogs with TNNT3: view

Variants for TNNT3 Gene

Sequence variations from dbSNP and Humsavar for TNNT3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4701 -- 1,934,425(+) CCAAC(G/T)ACAGC missense, reference
rs4727 untested 1,938,477(+) GTCGG(C/T)GGGCG reference, synonymous-codon
rs9952 -- 1,938,495(-) TGGCC(G/T)CTCTA utr-variant-3-prime
rs10760 -- 1,938,602(-) ACTGT(C/G)AGGGA utr-variant-3-prime
rs491040 -- 1,935,108(-) ACGGG(C/G)TCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNNT3 Gene

Variant ID Type Subtype PubMed ID
nsv896727 CNV Gain 21882294
nsv896731 CNV Loss 21882294
nsv467645 CNV Gain 19166990
nsv469926 CNV Loss 18288195
dgv983n71 CNV Loss 21882294
esv29980 CNV Loss 17803354
nsv522320 CNV Loss 19592680
nsv7643 CNV Loss 18451855
nsv61 CNV Loss 15895083
nsv7213 OTHER Inversion 18451855
esv1011096 OTHER Inversion 20482838
esv2615443 OTHER Inversion 19546169
nsv513689 OTHER Inversion 21212237
dgv151e201 CNV Deletion 23290073
dgv34n16 OTHER Inversion 17901297
nsv896749 CNV Loss 21882294
dgv987n71 CNV Loss 21882294
nsv62 OTHER Inversion 15895083
nsv436657 OTHER Inversion 17901297
esv1001997 OTHER Inversion 20482838
dgv988n71 CNV Loss 21882294
nsv516622 CNV Loss 19592680
dgv989n71 CNV Loss 21882294
esv1007968 CNV Insertion 20482838
esv2743979 CNV Deletion 23290073
nsv7644 CNV Insertion 18451855
nsv63 CNV Insertion 15895083

Relevant External Links for TNNT3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNNT3 Gene

Disorders for TNNT3 Gene

(1) OMIM Diseases for TNNT3 Gene (600692)


  • Arthrogryposis, distal, 2B (DA2B) [MIM:601680]: A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA2B is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures. {ECO:0000269 PubMed:12865991}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for TNNT3 Gene

Relevant External Links for TNNT3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TNNT3: view

No data available for Novoseek inferred disease relationships and Genatlas for TNNT3 Gene

Publications for TNNT3 Gene

  1. Isolation and characterization of human fast skeletal beta troponin T cDNA: comparative sequence analysis of isoforms and insight into the evolution of members of a multigene family. (PMID: 8172653) Wu Q.-L. … Sarkar S. (DNA Cell Biol. 1994) 2 3 4 23
  2. Skeletal muscle contractile gene (TNNT3, MYH3, TPM2) mutations not found in vertical talus or clubfoot. (PMID: 19142688) Gurnett C.A. … Dobbs M.B. (Clin. Orthop. Relat. Res. 2009) 3 23 48
  3. Assignment of the human fast skeletal troponin T gene (TNNT3) to chromosome 11p15.5: evidence for the presence of 11pter in a monochromosome 9 somatic cell hybrid in NIGMS mapping panel 2. (PMID: 8838323) Mao C. … Sarkar S. (Genomics 1996) 3 23
  4. Identification of a fetal exon in the human fast troponin T gene. (PMID: 8062920) Briggs M.M. … Schachat F. (FEBS Lett. 1994) 3 4
  5. Mutations in TNNT3 cause multiple congenital contractures: a second locus for distal arthrogryposis type 2B. (PMID: 12865991) Sung S.S. … Bamshad M. (Am. J. Hum. Genet. 2003) 3 4

Products for TNNT3 Gene

Sources for TNNT3 Gene

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