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TNNT2 Gene

protein-coding GIFtS: 66

GC01M199594

troponin T type 2 (cardiac)
(Previous names: troponin T2, cardiac, cardiomyopathy, hypertrophic 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CMH2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CMD1D ^⁵
CMH2 ^², ⁵
CMPD2 ^²
MGC3889 ^²
OTTHUMP00000033864 ^²
OTTHUMP00000033867 ^²
RCM3 ^², ⁵
TnTC ^²
TnTc ^³
cTnT ^², ³

Descriptions
Cardiac muscle troponin T ^³
cardiomyopathy, dilated 1D (autosomal dominant) ^²
cardiomyopathy, hypertrophic 2 ^¹, ²
troponin T type 2 (cardiac) ^²
troponin T type 2, cardiac ^²
troponin T, cardiac muscle ^²
troponin T2, cardiac ^¹, ²

External Ids
HGNC: 11949¹
Entrez Gene: 7139²
UniProtKB: P45379³
Ensembl: ENSG00000118194⁷

Search outside databases for aliases for TNNT2 gene

Previous GC identifers: GC01P199302 GC01P197036 GC01M197794 GC01M198616 GC01M198059

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TNNT2:

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which

is located on the thin filament of striated muscles and regulates muscle contraction in response

to alterations in intracellular calcium ion concentration. Mutations in this gene have been

associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy.

Transcripts for this gene undergo alternative splicing that results in many tissue-specific

isoforms, however, the full-length nature of some of these variants has not yet been determined.

[provided by RefSeq]

UniProtKB/Swiss-Prot: TNNT2_HUMAN, P45379

Function: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory

complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity

Gene Wiki entry for TNNT2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TNNT2 gene

Entrez Gene cytogenetic band: 1q32 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32

TNNT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M199594: (about GC identifiers)

Start:	199,594,759 bp from pter
End:	199,613,431 bp from pter
Size:	18,673 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TNNT2_HUMAN, P45379 (See protein sequence)

Recommended Name: Troponin T, cardiac muscle

Size: 298 amino acids; 35924 Da

PDB structure from and Proteopedia :

1J1D (3D)

1J1E (3D)

Secondary accessions: A8K3K6 O60214 Q99596 Q99597 Q9UM96

Alternative splicing: 10 isoforms: P45379-1 P45379-2 P45379-3 P45379-4 P45379-5 P45379-6 P45379-7 P45379-8

P45379-9 P45379-10 (Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_000355.2 NP_001001430.1 NP_001001431.1 NP_001001432.1

ENSEMBL proteins:

ENSP00000350511 ENSP00000236918 ENSP00000356286 ENSP00000356287 ENSP00000353535 ENSP00000356291

ENSP00000356289 ENSP00000356288 ENSP00000356284

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for TNNT2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Cardiac Troponin T, Troponin T1 + T2 + T3)
	Human Recombinant Proteins from Abnova (TNNT2)

OriGene Purified Recombinant Human Proteins (see all 2): TNNT2

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005861	troponin complex	IDA	12186860

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Antibodies for TNNT2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TNNT2
	R&D Systems Antibodies for TNNT2 (Troponin T)
	Antibodies from Abcam (Cardiac Troponin T, Troponin T1 + T2 + T3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TNNT2)
	Novus Biologicals Antibodies for TNNT2

Assays for TNNT2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P45379

ProtoNet protein and cluster: P45379

1 Blocks protein family: IPB001978 Troponin

UniProtKB/Swiss-Prot: TNNT2_HUMAN, P45379

Similarity: Belongs to the troponin T family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TNNT2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TNNT2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000364

Applied Biosystems Silencer® siRNAs for TNNT2

Sigma-Aldrich siRNA and siRNA Panels for TNNT2

Sigma-Aldrich shRNA for TNNT2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TNNT2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000364
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000364
untagged cDNA clones in CMV expression vector (see all 4): NM_000364

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000364

UniProtKB/Swiss-Prot: TNNT2_HUMAN, P45379

Function: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory

complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity

Genatlas biochemistry entry for TNNT2:

troponin T2,component of the troponin complex forming the calcium-sensitive molecular switch that

regulates striated muscle contraction in response to modifications in intracellular

concentration,cardiac muscle,regulating striated muscle contraction in response to alterations in

intracellular calcium concentration,including multiple isoforms,involved in the attachment of the

complex to tropomyosin and troponin I

7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tnnt2):

	embryogenesis	growth/size	lethality-prenatal/perinatal	life span-post-weaning/aging
muscle	normal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IDA	8205619
GO:0005523	tropomyosin binding	IDA	10850966
GO:0030172	troponin C binding	IPI	8205619 15542288
GO:0031013	troponin I binding	IPI	15542288

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for TNNT2 (Your Favorite Gene powered by Ingenuity)

Calcium Signaling

GeneDecks TNNT2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for TNNT2

5/69 Interacting proteins for TNNT2 (ENSP00000356286³) via UniProtKB, MINT, and/or STRING (see all 69 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TNNC1	ENSP00000232975³	STRING (score=.999)
TNNI3	ENSP00000341838³	STRING (score=.999)
TPM1	ENSP00000350667³	STRING (score=.999)
TNNC2	ENSP00000361636³	STRING (score=.998)
TNNI1	ENSP00000351548³	STRING (score=.997)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008016	regulation of heart contraction	IMP	15542288
GO:0030049	muscle filament sliding	IDA	12186860 15923195
GO:0032780	negative regulation of ATPase activity	IDA	10850966
GO:0032781	positive regulation of ATPase activity	IDA	10850966 12186860
GO:0051592	response to calcium ion	IMP	8205619

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TNNT2
3 Novoseek chemical compound relationships for TNNT2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ptca	13.08	2	11208396 (2)
fatty acid	8.65	2	17926199 (1), 18999883 (1)
glycogen	6.80	1	18999883 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TNNT2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TNNT2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000364

Sigma-Aldrich siRNA and siRNA Panels for TNNT2

Sigma-Aldrich shRNA for TNNT2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000364 NM_001001430 NM_001001431 NM_001001432

REFSEQ mRNAs for TNNT2 gene (4 alternative transcripts):

NM_000364.2 NM_001001430.1 NM_001001431.1 NM_001001432.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000364 NM_001001430 NM_001001431 NM_001001432

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000364
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000364
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_000364

Additional cDNA sequence:

AK290621.1 AK309493.1 AL832707.1 AY277394.1 BC002653.2 L40162.1 S64668.1 X74819.1

X79855.1 X79856.1 X79858.1 X79859.1 X79861.1 X83743.1 X83744.1

18 DOTS entries:

DT.118095 DT.121454721 DT.100754093 DT.91695044 DT.100655158 DT.40208592 DT.99954344 DT.121454688

DT.95158177 DT.92424285 DT.95158176 DT.102842687 DT.121454692 DT.40208593 DT.87016979 DT.92424281

DT.95158182 DT.121454687

24/147 AceView cDNA sequences (see all 147 ):

NM_001001431 CA438630 AJ709472 AA362046 AJ709042 NM_000364 X79858 T28266

AJ706904 AY277394 NM_001001432 C05166 C04363 AJ709028 AJ706907 N87772

AI338772 AJ708802 AJ708866 C05043 AI367750 C04915 CF551854 AJ709460

highest scoring ESTs for TNNT2:

AA089987 AA092121 AA093091 AA093216 AA249219 AJ706750 AJ706854 AJ707426 AJ708269 AJ708444

Unigene Cluster for TNNT2:

Troponin T type 2 (cardiac)

Hs.533613 [show with all ESTs]

Unigene Representative Sequence: AL832707

GeneLoc Exon Structure

9 Ensembl transcripts including schematic representations:

ENST00000357848 ENST00000236918 ENST00000367317 ENST00000367318 ENST00000360372 ENST00000367322

ENST00000367320 ENST00000367319 ENST00000367315

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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TNNT2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TNNT2

¹ / ² / ³

3 probe-sets matching TNNT2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38793_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X74819	0.80	1.00	0.91	1
215389_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X79857	0.40	1.00	0.76	1
215389_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks TNNT2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATGCATTTTG

SOURCE GeneReport for Unigene cluster: Hs.533613
Expression variation in blood from EXPOLDB for TNNT2
UniProtKB/Swiss-Prot: TNNT2_HUMAN, P45379
Tissue specificity: Heart. The fetal heart shows a greater expression in the atrium than in the
ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium.
Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart.
Isoform 7 is also expressed in failing adult heart

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for TNNT2 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TNNT2¹	--	troponin T type 2 (cardiac)	89.64(n) 92.14(a)	403532 NM_001003012.1 NP_001003012.1
chimpanzee (Pan troglodytes)	TNNT2¹	--	troponin T type 2 (cardiac)	99.44(n) 99.66(a)	457618 XM_001146358.1 XP_001146358.1
rat (Rattus norvegicus)	Tnnt2¹	--	troponin T type 2 (cardiac)	85.54(n) 88.14(a)	24837 NM_012676.1 NP_036808.1
mouse (Mus musculus)	Tnnt2^{1, 5}	1 (60.00 cM)⁵	troponin T2, cardiac^{1, 5}	86.13(n)¹ 89.51(a)¹	21956¹ NM_011619.1¹ NP_035749.1¹ AB052890⁵ AK086260⁵ (see all 23)
chicken (Gallus gallus)	TNNT2¹	--	troponin T type 2 (cardiac)	76.03(n) 76.71(a)	396433 NM_205449.1 NP_990780.1

About this table Species with no ortholog for TNNT2

ENSEMBL Gene Tree for TNNT2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for TNNT2 gene

TNNT1² TNNT3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/217 NCBI SNPs in TNNT2 are shown (see all 217 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 138)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2799691^1,2	A,C,F,H	199614966(+)	`AGGAGT/CCAGGC`	4	--	ng3¹		8	EU EA WA	838
	rs4915232^1,2	A,C,F,H	199614569(-)	`GATTGG/AGTGAT`	4	--	ng3¹		11	NA EU EA WA	952
--	rs946639^1,2	A,C,F,H	199614886(+)	`AGGACG/CACCAC`	4	--	ng3¹		4	EU EA WA	400
--	rs2799690^1,2	A,C,F,H	199614871(+)	`AGCATC/TGTGGG`	4	--	ng3¹		3	EU EA	298
	rs3730246^1,2	C,F,H	199594697(-)	`CAGGTC/TCCCGG`	4	--	ng5¹		12	EU EA WA NS	1328
--	rs3730238^1,2	C,F,H	199597052(-)	`GGAGAA/GGTTCA`	4	K/R	mis¹		16	EU EA WA NS	1732
	rs2275864^1,2	C,F,H	199594718(-)	`TGAGGC/TGAGAC`	4	--	ng5¹		13	EA EU WA NS	2786
	rs3730245^1,2	C,F,H	199594736(-)	`TCAGAG/AAGAGA`	4	--	ng5¹		12	EU EA WA NS	1322
	rs10920180^1,2	A,C,F	199594517(+)	`TCTGTC/TCCCCT`	4	--	ng5¹		4	NS	498
	rs2799686^1,2	C,F,H	199613938(+)	`GCCTTG/AGGCAG`	4	--	ng3¹		11	NA EU EA WA	982

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HapMap Linkage Disequilibrium images for TNNT2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 191045 disorders: 115195 601494 612422

UniProtKB/Swiss-Prot: TNNT2_HUMAN, P45379

Defects in TNNT2 are the cause of cardiomyopathy familial hypertrophic type 2 (CMH2)

[MIM:115195]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by

ventricular hypertrophy, which is usually asymmetric and often involves the interventricular

septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be

readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from

benign to malignant forms with high risk of cardiac failure and sudden cardiac death

Defects in TNNT2 are the cause of cardiomyopathy dilated type 1D (CMD1D) [MIM:601494].

Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic

function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature

death

Defects in TNNT2 are the cause of cardiomyopathy familial restrictive type 3 (RCM3)

[MIM:612422]. Restrictive cardiomyopathy is a heart disorder characterized by impaired filling of

the ventricles with reduced diastolic volume, in the presence of normal or near normal wall

thickness and systolic function

10/22 Novoseek disease relationships for TNNT2 gene (see all 22 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
death sudden cardiac	57.81	1	12881443 (1)
dilated cardiomyopathy	56.19	4	11967535 (1), 11779518 (1), 14654368 (1), 16093482 (1)
death sudden	52.34	4	11857753 (1), 14563299 (1), 11967535 (1), 11779518 (1)
acute myocardial infarction	49.03	14	12649923 (3), 9857757 (1), 17926199 (1), 9028628 (1) (see all 9)
ventricular hypertrophy	47.88	5	10462276 (2), 17289431 (1), 9714088 (1), 14986170 (1)
heart failure	45.33	6	15819505 (1), 14697983 (1), 17289431 (1), 11967535 (1) (see all 5)
myocardial infarction	44.68	4	12815787 (1), 12955276 (1), 14662251 (1)
hypertrophy	41.08	2	12881443 (1), 9714088 (1)
cardiac hypertrophy	40.68	2	11857753 (1), 14986170 (1)
myopathy	40.23	7	11026100 (2), 9857757 (1), 9028628 (1), 10094373 (1)

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GeneTests: TNNT2

Dilated Cardiomyopathy

Human Gene Mutation Database: TNNT2
Genetic Association Database: TNNT2
Human Genome Epidemiology Navigator: TNNT2 (21 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/211 PubMed articles for TNNT2 gene (see all 211 ):

Mutation screening in dilated cardiomyopathy: prominent role of the beta myosin heavy chain gene. (PubMed id 15769782)^{1, 3, 4, 6} Villard E.... Komajda M. (2005)
A rapid protocol for cardiac troponin T gene mutation detection in familial hypertrophic cardiomyopathy. (PubMed id 9482583)^{1, 2, 3, 4} Gerull B....Thierfelder L. (1998)
Mutations profile in Chinese patients with hypertrophic cardiomyopathy. (PubMed id 15563892)^{1, 3, 4, 6} Song L.... Hui R. (2005)
Human cardiac troponin T: identification of fetal isoforms and assignment of the TNNT2 locus to chromosome 1q. (PubMed id 8088824)^{1, 2, 3, 4} Townsend P.J.... Barton P.J.R. (1994)
Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling. (PubMed id 16199542)^{1, 3, 4, 6} Ingles J.... Semsarian C. (2005)
The role of a common TNNT2 polymorphism in cardiac hypertrophy. (PubMed id 14986170)^{1, 3, 6} Komamura K....Miyatake K. (2004)
Novel missense mutation in cardiac troponin T gene found in Japanese patient with hypertrophic cardiomyopathy. (PubMed id 9140840)^{1, 3, 4} Nakajima-Taniguchi C....Yamauchi-Takihara K. (1997)
Codon 102 of the cardiac troponin T gene is a putative hot spot for mutations in familial hypertrophic cardiomyopathy. (PubMed id 8989109)^{1, 3, 4} Forissier J.F....Schwartz K. (1996)
Homozygous mutation in cardiac troponin T: implications for hypertrophic cardiomyopathy. (PubMed id 11034944)^{1, 3, 4} Ho C.Y....Seidman C.E. (2000)
Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. (PubMed id 15542288)^{1, 3, 4} Mogensen J....McKenna W.J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7139	HGNC: 11949	AceView: TNNT2	Ensembl:ENSG00000118194	euGenes: HUgn7139
ECgene: TNNT2	H-InvDB: TNNT2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Familial hypertrophic cardiomyopathy mutation database	http://www.angis.org.au/Databases/Heart/heartbreak.html
GeneReviews	http://www.genetests.org/query?gene=TNNT2

Licensable Technologies for TNNT2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for TNNT2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TNNT2-related products

	Millipore Custom Antibody & Bulk Services
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	Predesigned and custom siRNAs for TNNT2		Antibodies for TNNT2
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	Recombinant Proteins (Cardiac Troponin T, Troponin T1 + T2 + T3)
	Antibodies (Cardiac Troponin T, Troponin T1 + T2 + T3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for TNNT2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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TNNT2 Gene at Home site.
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TNNT2 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for TNNT2

Summaries
for TNNT2

Genomic Location
for TNNT2

Proteins
for TNNT2

Protein Domains/
Families
for TNNT2

Gene Function
for TNNT2

Pathways & Interactions
for TNNT2

Drugs & Compounds
for TNNT2

Transcripts
for TNNT2

Expression
for TNNT2

Orthologs
for TNNT2

Paralogs
for TNNT2

SNPs/Variants
for TNNT2

Disorders & Mutations
for TNNT2

Medical News
for TNNT2

Publications
for TNNT2

Search for TNNT2

Genome Databases showing TNNT2

Other Databases showing TNNT2

Specialized Databases showing TNNT2

Licensable Technologies
for TNNT2

Services
for TNNT2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TNNT2 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor TNNT2

Summariesfor TNNT2

Genomic Locationfor TNNT2

Proteinsfor TNNT2

Protein Domains/Familiesfor TNNT2

Gene Functionfor TNNT2

Pathways & Interactionsfor TNNT2

Drugs & Compoundsfor TNNT2

Transcriptsfor TNNT2

Expression for TNNT2

Orthologsfor TNNT2

Paralogsfor TNNT2

SNPs/Variantsfor TNNT2

Disorders & Mutationsfor TNNT2

Medical Newsfor TNNT2

Publicationsfor TNNT2

Search for TNNT2

Genome Databases showing TNNT2

Other Databases showing TNNT2

Specialized Databases showing TNNT2

Licensable Technologiesfor TNNT2

Servicesfor TNNT2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TNNT2

Summaries
for TNNT2

Genomic Location
for TNNT2

Proteins
for TNNT2

Protein Domains/
Families
for TNNT2

Gene Function
for TNNT2

Pathways & Interactions
for TNNT2

Drugs & Compounds
for TNNT2

Transcripts
for TNNT2

Expression
for TNNT2

Orthologs
for TNNT2

Paralogs
for TNNT2

SNPs/Variants
for TNNT2

Disorders & Mutations
for TNNT2

Medical News
for TNNT2

Publications
for TNNT2

Licensable Technologies
for TNNT2

Services
for TNNT2