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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNNI3K Gene

protein-coding   GIFtS: 55
GCID: GC01P074669

TNNI3 Interacting Kinase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TNNI3 Interacting Kinase1 2     Serine/Threonine-Protein Kinase TNNI3K2
Cardiac Ankyrin Repeat Kinase2 3     EC 2.7.11.13
Cardiac Troponin I-Interacting Kinase2 3     TNNI3-Interacting Kinase3
CARK2 3     

External Ids:    HGNC: 196611   Entrez Gene: 510862   Ensembl: ENSG000001167837   OMIM: 6139325   UniProtKB: Q59H183   

Export aliases for TNNI3K gene to outside databases

Previous GC identifers: GC01P074071 GC01P074413 GC01P074664 GC01P074666


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNNI3K Gene:
This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The
protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac
physiology. (provided by RefSeq, Sep 2012)

GeneCards Summary for TNNI3K Gene: 
TNNI3K (TNNI3 interacting kinase) is a protein-coding gene. Diseases associated with TNNI3K include ventricular septal defect, and coronary heart disease. GO annotations related to this gene include protein serine/threonine kinase activity and protein C-terminus binding. An important paralog of this gene is FPGT-TNNI3K.

UniProtKB/Swiss-Prot: TNI3K_HUMAN, Q59H18
Function: May play a role in cardiac physiology




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNNI3K gene promoter:
         Pbx1a   GCNF   STAT5A   YY1   FOXL1   GATA-1   GCNF-1   GCNF-2   NF-kappaB1   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TNNI3K

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNNI3K


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

TNNI3K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNNI3K gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P074669:  view genomic region     (about GC identifiers)

Start:
74,663,937 bp from pter      End:
75,010,116 bp from pter
Size:
346,180 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNI3K_HUMAN, Q59H18 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase TNNI3K  
Size: 835 amino acids; 92851 Da
Cofactor: Magnesium
Subunit: Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB
Subcellular location: Nucleus. Cytoplasm. Note=Expressed at lower levels in the cytoplasm
Sequence caution: Sequence=BAD92178.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAE45949.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q17RN0 Q49AR1 Q6MZS9 Q9Y2V6
Alternative splicing: 4 isoforms:  Q59H18-2   Q59H18-1   Q59H18-3   Q59H18-4   (Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein)

Explore the universe of human proteins at neXtProt for TNNI3K: NX_Q59H18

Explore proteomics data for TNNI3K at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q59H18

  • TNNI3K Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNNI3K Protein Expression
    REFSEQ proteins: NP_057062.1  
    ENSEMBL proteins: 
     ENSP00000359930   ENSP00000322251   ENSP00000431465   ENSP00000434975   ENSP00000433550  
     ENSP00000359928  

    Human Recombinant Protein Products for TNNI3K: 
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    Cloud-Clone Corp. Proteins for TNNI3K 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12721663
    GO:0005737cytoplasm IDA12721663

    TNNI3K for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: TNNI3 interacting kinase 
    HH498 subfamily

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q59H18

    ProtoNet protein and cluster: Q59H18

    UniProtKB/Swiss-Prot: TNI3K_HUMAN, Q59H18
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 10 ANK repeats
    Similarity: Contains 1 protein kinase domain


    TNNI3K for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNI3K_HUMAN, Q59H18
    Function: May play a role in cardiac physiology
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA12721663
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12721663
    GO:0005524ATP binding IEA--
         
    TNNI3K for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TNNI3K:
     Decreased substrate adherent c  Gemcitabine induced cell-death  Increased cell death HMECs cel  Paclitaxel antagonistic effect 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidTNNI3K 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNNI3K

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/16 Interacting proteins for TNNI3K (Q59H181, 3 ENSP000003599284) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNNI3P194291, 3, ENSP000003418384EBI-704142,EBI-704146 I2D: score=3 STRING: ENSP00000341838
    ACTA1P681333, ENSP000003556454I2D: score=3 STRING: ENSP00000355645
    ACTC1P680323, ENSP000002903784I2D: score=3 STRING: ENSP00000290378
    MYBPC3Q148963, ENSP000003821934I2D: score=3 STRING: ENSP00000382193
    AIPO001703, ENSP000002791464I2D: score=3 STRING: ENSP00000279146
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA12721663

    TNNI3K for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNNI3K (TNI3K)

    1 HMDB Compound for TNNI3K    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about TNNI3K / TNI3K

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNNI3K gene: 
    NM_015978.2  

    Unigene Cluster for TNNI3K:

    TNNI3 interacting kinase
    Hs.480085  [show with all ESTs]
    Unigene Representative Sequence: NM_003838
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533006 ENST00000370893 ENST00000326637(uc001dgf.2) ENST00000530184
    ENST00000497284 ENST00000526236 ENST00000534020 ENST00000525480 ENST00000370889
    ENST00000465473 ENST00000370891(uc001dge.2)
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TNNI3K:
    hsa-miR-223 hsa-miR-626
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    Additional mRNA sequence: 

    AF017445.1 AF116826.1 AK126321.1 AK223254.1 AK294948.1 AK299468.1 AK304490.1 AK307984.1 
    AY303691.1 BC020720.1 BC032308.1 BC113539.1 BC117262.1 

    18 DOTS entries:

    DT.112517  DT.104148  DT.100816378  DT.91716010  DT.91847061  DT.92440057  DT.95263385  DT.40129090 
    DT.91713938  DT.100019681  DT.121423053  DT.91923813  DT.97858459  DT.121423100  DT.303274  DT.75197315 
    DT.92440060  DT.92440065 

    24/199 AceView cDNA sequences (see all 199):

    CK819259 AI298368 BG940401 Z39211 AW475012 BQ722029 BX112488 BX099674 
    AI377988 AA490306 AU130402 AA938871 AI383084 BX501623 BP342463 AF116826 
    AI375137 AA707390 AI741185 BQ774566 AA280262 NM_015978 Z43126 F12805 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TNNI3K (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c
    SP1:                          -           -                                                               
    SP2:                          -           -     -                 -     -     -     -     -               
    SP3:                          -           -     -                                                         
    SP4:                          -                 -                                                         
    SP5:                                            -                                                         


    ECgene alternative splicing isoforms for TNNI3K

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNNI3K expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACTGCTTT
    TNNI3K Expression
    About this image


    See TNNI3K Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNNI3K

    SOURCE GeneReport for Unigene cluster: Hs.480085

    UniProtKB/Swiss-Prot: TNI3K_HUMAN, Q59H18
    Tissue specificity: Highly expressed in both adult and fetal heart

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TNNI3K gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnni3k1 , 5 TNNI3 interacting kinase1, 5 85.13(n)1
    91.01(a)1
      3 (79.32 cM)5
    4357661  NM_177066.51  NP_796040.31 
     1547863025 
    chicken
    (Gallus gallus)
    Aves TNNI3K1 TNNI3 interacting kinase 81.79(n)
    91.48(a)
      100533999  NM_001204816.1  NP_001191745.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    91(a)
    possible ortholog
    GL343194.1(2418276-2645629)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.300192 Xenopus laevis transcribed sequence with strong similarity more 81.46(n)    BG406579.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tnni3k1 TNNI3 interacting kinase 74.13(n)
    85.27(a)
      799621  NM_001204823.1  NP_001191752.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C24A1.31 Protein C24A1.3 54.04(n)
    49.58(a)
      175225  NM_001026011.1  NP_001021182.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VIK1 VH1-interacting kinase 47.51(n)
    37.02(a)
      837960  NM_101266.4  NP_172853.1 


    ENSEMBL Gene Tree for TNNI3K (if available)
    TreeFam Gene Tree for TNNI3K (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNNI3K gene
    FPGT-TNNI3K2  MAP3K122  MAP3K112  KIAA18042  RAF12  KSR22  KSR12  MOS2  
    BRAF2  MAP3K92  MAP3K102  ARAF2  MAP3K72  ZAK2  MAP3K132  ILK2  
    18/25 SIMAP similar genes for TNNI3K using alignment to 5 protein entries:     TNI3K_HUMAN (see all proteins) (see all similar genes):
    FPGT-TNNI3K    FPGT    TESK2    ZAK    RPS6KA2    KSR1
    EGFR    CDKN2A    ERBB2    DKFZp686M05208    EZR-ROS1    LRIG3(NM_001136051)-ROS1
    LRIG3(NM_153377)-ROS1    R32    R34    SLC34A2-ROS1    TPM3-ROS1    JAK2

    TNNI3K for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6383 SNPs in TNNI3K are shown (see all 6383)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356394
    A colorectal cancer sample4--see VAR_0356392 R G mis40--------
    VAR_0412264
    A colorectal adenocarcinoma sample4--see VAR_0412262 S L mis40--------
    VAR_0412304
    A head & Neck squamous cell carcinoma sample4--see VAR_0412302 M I mis40--------
    VAR_0412254
    ----see VAR_0412252 F L mis40--------
    rs756613381,2
    --72835238(+) TCTTAA/TTCTTA 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1846534771,2
    C--72855865(+) CGAGAA/CTCCGT 1 -- int10--------
    rs1892154361,2
    C--72855869(+) ACTCCA/GTCTCA 1 -- int10--------
    rs57752291,2
    C,F--72869105(+) CAATAT/-TTTAT 1 -- int14Minor allele frequency- -:0.50NA CSA 8
    rs2004313491,2
    --72890209(+) GAGAC-/TTAGTCA 1 -- int10--------
    rs785552711,2
    C--72895494(+) TAATT-/AATTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TNNI3K (74663937 - 74913937 bp, first 250kb of TNNI3K)

    Structural Variations
         Database of Genomic Variants (DGV) 10/29 variations for TNNI3K (see all 29):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749963CNV Deletion23290073
    esv2549117CNV Deletion19546169
    esv4202CNV Deletion18987735
    esv1000471CNV Deletion20482838
    esv2749941CNV Deletion23290073
    esv1932816CNV Deletion18987734
    esv1327381CNV Deletion17803354
    esv2350476CNV Deletion18987734
    esv2660597CNV Deletion23128226
    esv2749952CNV Deletion23290073


    Human Gene Mutation Database (HGMD): TNNI3K
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TNNI3K
    DNA2.0 Custom Variant and Variant Library Synthesis for TNNI3K

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613932    OMIM disorders: --

    3 diseases for TNNI3K:    About MalaCards
    ventricular septal defect    coronary heart disease    myocardial infarction


    TNNI3K for disorders           About GeneDecksing

    Genetic Association Database (GAD): TNNI3K
    Human Genome Epidemiology (HuGE) Navigator: TNNI3K (4 documents)

    Export disorders for TNNI3K gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNNI3K gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with TNNI3K)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I. (PubMed id 12721663)1, 2, 3 Zhao Y.... Ding J.-F. (2003)
    2. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1, 4 Speliotes E.K....Loos R.J. (2010)
    3. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PubMed id 20808825)1, 4 Chen X....Kong X. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Overexpression of TNNI3K, a cardiac-specific MAP kinase, promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury. (PubMed id 18552163)1, 9 Lai Z.F....Kim-Mitsuyama S. (2008)
    8. Identification of the dual specificity and the functional domains of the cardiac-specific protein kinase TNNI3K. (PubMed id 17660584)1, 9 Feng Y....Meng X.M. (2007)
    9. Genome-wide meta-analysis identifies 11 new loci for a nthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (2013)
    10. Genome-wide association and longitudinal analyses reve al genetic loci linking pubertal height growth, pubertal timing and childhood ad iposity. (PubMed id 23449627)1 Cousminer D.L....Widen E. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51086 HGNC: 19661 AceView: FPGTandTNNI3K Ensembl:ENSG00000116783 euGenes: HUgn51086
    ECgene: TNNI3K H-InvDB: TNNI3K

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNNI3K Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/tnni3k/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNNI3K gene:
    Search GeneIP for patents involving TNNI3K

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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