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Aliases for TNNI3K Gene

Aliases for TNNI3K Gene

  • TNNI3 Interacting Kinase 2 3 5
  • Cardiac Troponin I-Interacting Kinase 3 4
  • Cardiac Ankyrin Repeat Kinase 3 4
  • CARK 3 4
  • TNNI3-Interacting Kinase 4
  • EC 4
  • CCDD 3

External Ids for TNNI3K Gene

Previous GeneCards Identifiers for TNNI3K Gene

  • GC01P074071
  • GC01P074413
  • GC01P074664
  • GC01P074666
  • GC01P074669
  • GC01P074673

Summaries for TNNI3K Gene

Entrez Gene Summary for TNNI3K Gene

  • This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012]

GeneCards Summary for TNNI3K Gene

TNNI3K (TNNI3 Interacting Kinase) is a Protein Coding gene. Diseases associated with TNNI3K include Cardiac Conduction Disease With Or Without Dilated Cardiomyopathy and Familial Atrial Tachyarrhythmia-Infra-Hisian Cardiac Conduction Disease. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FPGT-TNNI3K.

UniProtKB/Swiss-Prot for TNNI3K Gene

  • May play a role in cardiac physiology.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNNI3K Gene

Genomics for TNNI3K Gene

Regulatory Elements for TNNI3K Gene

Enhancers for TNNI3K Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TNNI3K on UCSC Golden Path with GeneCards custom track

Genomic Location for TNNI3K Gene

74,235,387 bp from pter
74,544,432 bp from pter
309,046 bases
Plus strand

Genomic View for TNNI3K Gene

Genes around TNNI3K on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNNI3K Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNNI3K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNNI3K Gene

Proteins for TNNI3K Gene

  • Protein details for TNNI3K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase TNNI3K
    Protein Accession:
    Secondary Accessions:
    • Q17RN0
    • Q49AR1
    • Q6MZS9
    • Q9Y2V6

    Protein attributes for TNNI3K Gene

    835 amino acids
    Molecular mass:
    92851 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB.
    • Sequence=BAD92178.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAE45949.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNNI3K Gene

    Alternative splice isoforms for TNNI3K Gene


neXtProt entry for TNNI3K Gene

Proteomics data for TNNI3K Gene at MOPED

Post-translational modifications for TNNI3K Gene

Other Protein References for TNNI3K Gene

No data available for DME Specific Peptides for TNNI3K Gene

Domains & Families for TNNI3K Gene

Gene Families for TNNI3K Gene

Suggested Antigen Peptide Sequences for TNNI3K Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
  • Contains 10 ANK repeats.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
  • Contains 10 ANK repeats.
genes like me logo Genes that share domains with TNNI3K: view

Function for TNNI3K Gene

Molecular function for TNNI3K Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
May play a role in cardiac physiology.

Enzyme Numbers (IUBMB) for TNNI3K Gene

Gene Ontology (GO) - Molecular Function for TNNI3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,IDA 12721663
GO:0031013 troponin I binding IPI 12721663
genes like me logo Genes that share ontologies with TNNI3K: view
genes like me logo Genes that share phenotypes with TNNI3K: view

Human Phenotype Ontology for TNNI3K Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for TNNI3K

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TNNI3K Gene

Localization for TNNI3K Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNNI3K Gene

Nucleus. Cytoplasm. Note=Expressed at lower levels in the cytoplasm.

Subcellular locations from

Jensen Localization Image for TNNI3K Gene COMPARTMENTS Subcellular localization image for TNNI3K gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for TNNI3K Gene

Pathways & Interactions for TNNI3K Gene

SuperPathways for TNNI3K Gene

No Data Available

Interacting Proteins for TNNI3K Gene

Gene Ontology (GO) - Biological Process for TNNI3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002027 regulation of heart rate IMP 24925317
GO:0086069 bundle of His cell to Purkinje myocyte communication IMP 23236294
genes like me logo Genes that share ontologies with TNNI3K: view

No data available for Pathways by source and SIGNOR curated interactions for TNNI3K Gene

Drugs & Compounds for TNNI3K Gene

(1) Drugs for TNNI3K Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with TNNI3K: view

Transcripts for TNNI3K Gene

Unigene Clusters for TNNI3K Gene

TNNI3 interacting kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNNI3K Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c
SP1: - -
SP2: - - - - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - - - - - - -
SP7: - -

Relevant External Links for TNNI3K Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNNI3K Gene

mRNA expression in normal human tissues for TNNI3K Gene

mRNA differential expression in normal tissues according to GTEx for TNNI3K Gene

This gene is overexpressed in Heart - Left Ventricle (x9.0), Brain - Cerebellar Hemisphere (x7.0), Brain - Cerebellum (x7.0), and Heart - Atrial Appendage (x4.8).

Protein differential expression in normal tissues from HIPED for TNNI3K Gene

This gene is overexpressed in Bone (34.4) and Heart (32.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TNNI3K Gene

SOURCE GeneReport for Unigene cluster for TNNI3K Gene Hs.480085

mRNA Expression by UniProt/SwissProt for TNNI3K Gene

Tissue specificity: Highly expressed in both adult and fetal heart.
genes like me logo Genes that share expression patterns with TNNI3K: view

Protein tissue co-expression partners for TNNI3K Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TNNI3K Gene

Orthologs for TNNI3K Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TNNI3K Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNNI3K 35
  • 92.61 (n)
  • 96.53 (a)
  • 95 (a)
(Canis familiaris)
Mammalia TNNI3K 35
  • 91.61 (n)
  • 94.84 (a)
  • 93 (a)
(Mus musculus)
Mammalia Tnni3k 35
  • 85.13 (n)
  • 91.01 (a)
Tnni3k 16
Tnni3k 36
  • 90 (a)
(Pan troglodytes)
Mammalia TNNI3K 35
  • 99.76 (n)
  • 99.52 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Tnni3k 35
  • 84.71 (n)
  • 91.38 (a)
(Monodelphis domestica)
Mammalia TNNI3K 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
-- 36
  • 14 (a)
(Gallus gallus)
Aves TNNI3K 35
  • 81.79 (n)
  • 91.48 (a)
  • 90 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tnni3k 35
  • 78.91 (n)
  • 89.68 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30019 35
(Danio rerio)
Actinopterygii tnni3k 35
  • 74.13 (n)
  • 85.27 (a)
tnni3k 36
  • 84 (a)
(Caenorhabditis elegans)
Secernentea C24A1.3 35
  • 54.08 (n)
  • 49.58 (a)
C24A1.3 36
  • 42 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons VIK 35
  • 47.47 (n)
  • 36.91 (a)
Species with no ortholog for TNNI3K:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNNI3K Gene

Gene Tree for TNNI3K (if available)
Gene Tree for TNNI3K (if available)

Paralogs for TNNI3K Gene

Paralogs for TNNI3K Gene

genes like me logo Genes that share paralogs with TNNI3K: view

Variants for TNNI3K Gene

Sequence variations from dbSNP and Humsavar for TNNI3K Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035639 A colorectal cancer sample
VAR_038821 -
VAR_038822 -
VAR_041223 -
VAR_041224 -

Structural Variations from Database of Genomic Variants (DGV) for TNNI3K Gene

Variant ID Type Subtype PubMed ID
nsv522147 CNV Loss 19592680
dgv245n71 CNV Gain 21882294
dgv246n71 CNV Gain 21882294
dgv247n71 CNV Loss 21882294
nsv870852 CNV Loss 21882294
nsv523474 CNV Loss 19592680
nsv870653 CNV Loss 21882294
nsv871150 CNV Loss 21882294
nsv871467 CNV Gain+Loss 21882294
dgv248n71 CNV Loss 21882294
dgv249n71 CNV Loss 21882294
esv6294 CNV Gain 19470904
esv2749941 CNV Deletion 23290073
esv2350476 CNV Deletion 18987734
esv4202 CNV Deletion 18987735
esv1000471 CNV Deletion 20482838
esv1327381 CNV Deletion 17803354
esv2749952 CNV Deletion 23290073
nsv870654 CNV Loss 21882294
nsv461984 CNV Loss 19166990
esv2660597 CNV Deletion 23128226
nsv820047 CNV Loss 19587683
esv274525 CNV Insertion 20981092
nsv830248 CNV Loss 17160897
nsv525557 CNV Loss 19592680
nsv871900 CNV Loss 21882294
esv2549117 CNV Deletion 19546169
esv1932816 CNV Deletion 18987734
esv2749963 CNV Deletion 23290073

Variation tolerance for TNNI3K Gene

Residual Variation Intolerance Score: 34.7% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNNI3K Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNNI3K Gene

Disorders for TNNI3K Gene

MalaCards: The human disease database

(5) MalaCards diseases for TNNI3K Gene - From: OMIM, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards


  • Cardiac conduction disease with or without dilated cardiomyopathy (CCDD) [MIM:616117]: A cardiac disorder characterized by atrial tachyarrhythmia and conduction system disease. Some patients have dilated cardiomyopathy. {ECO:0000269 PubMed:24925317}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TNNI3K

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TNNI3K: view

No data available for Genatlas for TNNI3K Gene

Publications for TNNI3K Gene

  1. Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I. (PMID: 12721663) Zhao Y. … Ding J.-F. (J. Mol. Med. 2003) 2 3 4 67
  2. Overexpression of TNNI3K, a cardiac-specific MAP kinase, promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury. (PMID: 18552163) Lai Z.F. … Kim-Mitsuyama S. (Am. J. Physiol. Heart Circ. Physiol. 2008) 3 23
  3. Identification of the dual specificity and the functional domains of the cardiac-specific protein kinase TNNI3K. (PMID: 17660584) Feng Y. … Meng X.M. (Gen. Physiol. Biophys. 2007) 3 23
  4. Troponin I-interacting protein kinase: a novel cardiac-specific kinase, emerging as a molecular target for the treatment of cardiac disease. (PMID: 24899531) Lal H. … Force T. (Circ. J. 2014) 3
  5. TNNI3K mutation in familial syndrome of conduction system disease, atrial tachyarrhythmia and dilated cardiomyopathy. (PMID: 24925317) Theis J.L. … Olson T.M. (Hum. Mol. Genet. 2014) 3

Products for TNNI3K Gene

Sources for TNNI3K Gene