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TNNI3K Gene

protein-coding   GIFtS: 53
GCID: GC01P074673

TNNI3 Interacting Kinase

  See TNNI3K-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TNNI3 Interacting Kinase1 2     Serine/Threonine-Protein Kinase TNNI3K2
Cardiac Ankyrin Repeat Kinase2 3     EC 2.7.11.13
Cardiac Troponin I-Interacting Kinase2 3     TNNI3-Interacting Kinase3
CARK2 3     

External Ids:    HGNC: 196611   Entrez Gene: 510862   Ensembl: ENSG000001167837   OMIM: 6139325   UniProtKB: Q59H183   

Export aliases for TNNI3K gene to outside databases

Previous GC identifers: GC01P074071 GC01P074413 GC01P074664 GC01P074666 GC01P074669


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNNI3K Gene:
This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The
protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac
physiology. (provided by RefSeq, Sep 2012)

GeneCards Summary for TNNI3K Gene:
TNNI3K (TNNI3 interacting kinase) is a protein-coding gene. Diseases associated with TNNI3K include restrictive cardiomyopathy. GO annotations related to this gene include protein serine/threonine kinase activity and protein C-terminus binding. An important paralog of this gene is FPGT-TNNI3K.

UniProtKB/Swiss-Prot: TNI3K_HUMAN, Q59H18
Function: May play a role in cardiac physiology




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNNI3K gene promoter:
         Pbx1a   GCNF   STAT5A   YY1   FOXL1   GATA-1   GCNF-1   GCNF-2   NF-kappaB1   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TNNI3K

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNNI3K


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

TNNI3K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNNI3K gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P074673:  view genomic region     (about GC identifiers)

Start:
74,663,947 bp from pter      End:
75,010,116 bp from pter
Size:
346,170 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TNI3K_HUMAN, Q59H18 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase TNNI3K  
Size: 835 amino acids; 92851 Da
Cofactor: Magnesium
Subunit: Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB
Sequence caution: Sequence=BAD92178.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAE45949.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q17RN0 Q49AR1 Q6MZS9 Q9Y2V6
Alternative splicing: 4 isoforms:  Q59H18-2   Q59H18-1   Q59H18-3   Q59H18-4   (Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein)

Explore the universe of human proteins at neXtProt for TNNI3K: NX_Q59H18

Explore proteomics data for TNNI3K at MOPED

Post-translational modifications: 

  • Autophosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TNNI3K Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057062.1  
    ENSEMBL proteins: 
     ENSP00000322251   ENSP00000431465   ENSP00000434975   ENSP00000433550   ENSP00000359928  

    TNNI3K Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TNNI3K

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: TNNI3 interacting kinase
    HH498 subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q59H18

    ProtoNet protein and cluster: Q59H18

    UniProtKB/Swiss-Prot: TNI3K_HUMAN, Q59H18
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 10 ANK repeats
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TNNI3K           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNI3K_HUMAN, Q59H18
    Function: May play a role in cardiac physiology
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA12721663
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12721663
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with TNNI3K           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for TNNI3K:
     Decreased substrate adherent c  Gemcitabine induced cell-death  Increased cell death HMECs cel  Paclitaxel antagonistic effect 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNNI3K
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    hsa-miR-223 hsa-miR-626
    SwitchGear 3'UTR luciferase reporter plasmidTNNI3K 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for TNNI3K 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNI3K_HUMAN, Q59H18: Nucleus. Cytoplasm. Note=Expressed at lower levels in the cytoplasm

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12721663
    GO:0005737cytoplasm IDA12721663

    Find genes that share ontologies with TNNI3K           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TNNI3K
    Interactions:

        GeneGlobe Interaction Network for TNNI3K

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for TNNI3K (Q59H181, 3 ENSP000003599284) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNNI3P194291, 3, ENSP000003418384EBI-704142,EBI-704146 I2D: score=3 STRING: ENSP00000341838
    ACTA1P681333, ENSP000003556454I2D: score=3 STRING: ENSP00000355645
    ACTC1P680323, ENSP000002903784I2D: score=3 STRING: ENSP00000290378
    MYBPC3Q148963, ENSP000003821934I2D: score=3 STRING: ENSP00000382193
    AIPO001703, ENSP000002791464I2D: score=3 STRING: ENSP00000279146
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA12721663

    Find genes that share ontologies with TNNI3K           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNNI3K (TNI3K)

    1 HMDB Compound for TNNI3K    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNNI3K gene: 
    NM_015978.2  

    Unigene Cluster for TNNI3K:

    TNNI3 interacting kinase
    Hs.480085  [show with all ESTs]
    Unigene Representative Sequence: NM_003838
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326637(uc001dgf.2) ENST00000530184 ENST00000497284 ENST00000526236
    ENST00000534020 ENST00000525480 ENST00000370889 ENST00000465473 ENST00000370891(uc001dge.2)

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate TNNI3K:
    hsa-miR-223 hsa-miR-626
    SwitchGear 3'UTR luciferase reporter plasmidTNNI3K 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TNNI3K
      QuantiFast Probe-based Assays in human, mouse, rat TNNI3K

    Additional mRNA sequence: 

    AF017445.1 AF116826.1 AK126321.1 AK223254.1 AK294948.1 AK299468.1 AK304490.1 AK307984.1 
    AY303691.1 BC020720.1 BC032308.1 BC113539.1 BC117262.1 

    18 DOTS entries:

    DT.112517  DT.104148  DT.100816378  DT.91716010  DT.91847061  DT.92440057  DT.95263385  DT.40129090 
    DT.91713938  DT.100019681  DT.121423053  DT.91923813  DT.97858459  DT.121423100  DT.303274  DT.75197315 
    DT.92440060  DT.92440065 

    Selected AceView cDNA sequences (see all 199):

    Z39211 AI383084 CK819259 AI338977 BX501623 BP342463 BX099674 Z43126 
    AW475012 BU622977 AI377988 AI375137 AA707390 BG940401 AF116826 BQ774566 
    AA758546 AI741185 F12805 BX112488 AA938871 NM_015978 AA280262 BQ722029 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TNNI3K (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c
    SP1:                          -           -                                                               
    SP2:                          -           -     -                 -     -     -     -     -               
    SP3:                          -           -     -                                                         
    SP4:                          -                 -                                                         
    SP5:                                            -                                                         


    ECgene alternative splicing isoforms for TNNI3K

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNNI3K expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACTGCTTT
    TNNI3K Expression
    About this image

    TNNI3K Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNNI3K Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.480085

    UniProtKB/Swiss-Prot: TNI3K_HUMAN, Q59H18
    Tissue specificity: Highly expressed in both adult and fetal heart

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TNNI3K gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnni3k1 , 5 TNNI3 interacting kinase1, 5 85.13(n)1
    91.01(a)1
      3 (79.32 cM)5
    4357661  NM_177066.51  NP_796040.31 
     1547863025 
    chicken
    (Gallus gallus)
    Aves TNNI3K1 TNNI3 interacting kinase 81.79(n)
    91.48(a)
      100533999  NM_001204816.1  NP_001191745.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    91(a)
    1 → many
    GL343194.1(2418276-2645629)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.300192 Xenopus laevis transcribed sequence with strong similarity more 81.46(n)    BG406579.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tnni3k1 TNNI3 interacting kinase 74.13(n)
    85.27(a)
      799621  NM_001204823.1  NP_001191752.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C24A1.31 C24A1.3 54.08(n)
    49.58(a)
      175225  NM_001026011.2  NP_001021182.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VIK1 VIK 47.47(n)
    36.91(a)
      837960  NM_101266.4  NP_172853.1 


    ENSEMBL Gene Tree for TNNI3K (if available)
    TreeFam Gene Tree for TNNI3K (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNNI3K gene
    FPGT-TNNI3K2  MAP3K122  MAP3K112  KIAA18042  RAF12  KSR22  KSR12  MOS2  
    BRAF2  MAP3K92  MAP3K102  ARAF2  MAP3K72  ZAK2  MAP3K132  ILK2  
    Selected SIMAP similar genes for TNNI3K using alignment to 4 protein entries:     TNI3K_HUMAN (see all proteins) (see all similar genes):
    FPGT-TNNI3K    TESK2    ZAK    RPS6KA2    KSR1    EGFR
    CDKN2A    ERBB2    DKFZp686M05208    EZR-ROS1    LRIG3(NM_001136051)-ROS1    LRIG3(NM_153377)-ROS1
    R32    R34    SLC34A2-ROS1    TPM3-ROS1    JAK2    MLKL

    Find genes that share paralogs with TNNI3K           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNNI3K (see all 6383)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356394
    A colorectal cancer sample4--see VAR_0356392 R G mis40--------
    VAR_0412264
    A colorectal adenocarcinoma sample4--see VAR_0412262 S L mis40--------
    VAR_0412304
    A head & Neck squamous cell carcinoma sample4--see VAR_0412302 M I mis40--------
    rs756613381,2
    --72835238(+) TCTTAA/TTCTTA 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1846534771,2
    C--72855865(+) CGAGAA/CTCCGT 1 -- int10--------
    rs1892154361,2
    C--72855869(+) ACTCCA/GTCTCA 1 -- int10--------
    rs57752291,2
    C,F--72869105(+) CAATAT/-TTTAT 1 -- int14Minor allele frequency- -:0.50NA CSA 8
    rs2004313491,2
    --72890209(+) GAGAC-/TTAGTCA 1 -- int10--------
    rs785552711,2
    C--72895494(+) TAATT-/AATTTT 1 -- int10--------
    rs106331371,2
    C--72897838(+) tgtgc-/ATGT/GT
    GT
    /GTGTGT
    gtgtg
    2 -- int1 cds10--------

    HapMap Linkage Disequilibrium report for TNNI3K (74663947 - 74913947 bp, first 250kb of TNNI3K)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TNNI3K (see all 29):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749963CNV Deletion23290073
    esv2549117CNV Deletion19546169
    esv4202CNV Deletion18987735
    esv1000471CNV Deletion20482838
    esv2749941CNV Deletion23290073
    esv1932816CNV Deletion18987734
    esv1327381CNV Deletion17803354
    esv2350476CNV Deletion18987734
    esv2660597CNV Deletion23128226
    esv2749952CNV Deletion23290073

    Human Gene Mutation Database (HGMD): TNNI3K
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNNI3K
    DNA2.0 Custom Variant and Variant Library Synthesis for TNNI3K

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613932    OMIM disorders: --

    1 disease for TNNI3K:    
    About MalaCards
    restrictive cardiomyopathy


    Find genes that share disorders with TNNI3K           About GenesLikeMe

    Genetic Association Database (GAD): TNNI3K
    Human Genome Epidemiology (HuGE) Navigator: TNNI3K (4 documents)

    Export disorders for TNNI3K gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TNNI3K gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with TNNI3K)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I. (PubMed id 12721663)1, 2, 3 Zhao Y.... Ding J.-F. (J. Mol. Med. 2003)
    2. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1, 4 Speliotes E.K....Loos R.J. (Nat. Genet. 2010)
    3. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PubMed id 20808825)1, 4 Chen X....Kong X. (PLoS ONE 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Overexpression of TNNI3K, a cardiac-specific MAP kinase, promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury. (PubMed id 18552163)1, 9 Lai Z.F....Kim-Mitsuyama S. (Am. J. Physiol. Heart Circ. Physiol. 2008)
    8. Identification of the dual specificity and the functional domains of the cardiac-specific protein kinase TNNI3K. (PubMed id 17660584)1, 9 Feng Y....Meng X.M. (Gen. Physiol. Biophys. 2007)
    9. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (Nat. Genet. 2013)
    10. Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. (PubMed id 23449627)1 Cousminer D.L....WidAcn E. (Hum. Mol. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 51086 HGNC: 19661 AceView: FPGTandTNNI3K Ensembl:ENSG00000116783 euGenes: HUgn51086
    ECgene: TNNI3K H-InvDB: TNNI3K

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TNNI3K Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/tnni3k/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TNNI3K gene:
    Search GeneIP for patents involving TNNI3K

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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