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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TNNI2 Gene

protein-coding GIFtS: 63
GCID: GC11P001860

troponin I type 2 (skeletal, fast)

(Previous names: troponin I, skeletal, fast )

Explore 10 diseases affiliated with
TNNI2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Troponin I Type 2 (Skeletal, Fast)¹ ²		Fast-Twitch Skeletal Muscle Troponin I²
AMCD2B¹ ² ⁵		FsTnI¹
DA2B¹ ² ⁵		Troponin I Fast Twitch 2²
FSSV¹ ² ⁵		Troponin I, Fast Skeletal Muscle²
Troponin I, Skeletal, Fast¹ ²		Troponin I, Fast-Twitch Skeletal Muscle Isoform²
Troponin I, Fast-Twitch Isoform² ³

External Ids:	HGNC: 11946¹	Entrez Gene: 7136²	Ensembl: ENSG00000130598⁷	OMIM: 191043⁵	UniProtKB: P48788³

Export aliases for TNNI2 gene to outside databases

Previous GC identifers: GC11M000778 GC11M001963 GC11P001819 GC11P001825 GC11P001821 GC11P001824 GC11P001651

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNNI2:

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the

troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with

tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show

that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle

function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an

inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a

co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian

carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript

variants have been found for this gene. (provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: TNNI2_HUMAN, P48788

Function: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers

calcium-sensitivity to striated muscle actomyosin ATPase activity

Gene Wiki entry for TNNI2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNNI2 gene promoter:
COUP-TF1 COUP Lmo2 HNF-4alpha2 AP-4 Tal-1beta Roaz HNF-4alpha1 E47 COUP-TF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNNI2 promoter sequence

Search SABiosciences Chromatin IP Primers for TNNI2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNNI2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5

TNNI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNNI2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P001860: view genomic region (about GC identifiers)

Start:	1,860,219 bp from pter	End:	1,862,910 bp from pter
Size:	2,692 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TNNI2_HUMAN, P48788 (See protein sequence)

Recommended Name: Troponin I, fast skeletal muscle

Size: 182 amino acids; 21339 Da

Subunit: Binds to actin and tropomyosin

Secondary accessions: A6NIV8 A6NJU5

Alternative splicing: 2 isoforms: P48788-1 P48788-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNNI2: NX_P48788

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P48788

TNNI2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001139301.1 NP_001139313.1 NP_003273.1

ENSEMBL proteins:

ENSP00000371336 ENSP00000371331 ENSP00000371330 ENSP00000252898

Reactome Protein details: P48788
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	Uscn Proteins for TNNI2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18331830
GO:0005829	cytosol	TAS	--
GO:0005861	troponin complex	IDA	17194691

TNNI2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNNI2 for domains About GeneDecksing

1 InterPro domain/family:

IPR001978 Troponin

Graphical View of Domain Structure for InterPro Entry P48788

ProtoNet protein and cluster: P48788

1 Blocks protein family: IPB001978 Troponin

UniProtKB/Swiss-Prot: TNNI2_HUMAN, P48788

Similarity: Belongs to the troponin I family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TNNI2_HUMAN, P48788

Function: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers

calcium-sensitivity to striated muscle actomyosin ATPase activity

Genatlas biochemistry entry for TNNI2:

troponin I2,inhibitory subunit,component of the troponin complex forming the calcium-sensitive molecular switch that

regulates striated muscle contraction in response to modifications in intracellular concentration,fast twitch skeletal

muscle,organized in pair with TNNT3,tightly linked to TNNT2 and ELF3

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	contributes to actin binding	IDA	17194691
GO:0005515	protein binding	IPI	18331830
GO:0031014	troponin T binding	IPI	17194691

TNNI2 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for TNNI2:

Decreased focal adhesion (FA)

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TNNI2

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

Striated Muscle Contraction

	Striated Muscle Contraction	1.00			Muscle contraction	0.65
	Striated Muscle Contraction	0.87

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNNI2

	Activation of PKA through GPCR
	PKA Signaling
	cAMP Pathway
	Activation of cAMP-Dependent PKA

1 BioSystems Pathway for TNNI2

Striated Muscle Contraction

2 Reactome Pathways for TNNI2

	Muscle contraction
	Striated Muscle Contraction

TNNI2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TNNI2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/38 Interacting proteins for TNNI2 (P48788^{2, 3} ENSP00000252898⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRIM63	Q969Q1²^,³, ENSP00000363390⁴	MINT-6503650 I2D: score=2 STRING: ENSP00000363390
CALM1	P62158³, ENSP00000349467⁴	I2D: score=1 STRING: ENSP00000349467
CALM2	P62158³	I2D: score=1
CALM3	P62158³	I2D: score=1
SMURF2	Q9HAU4²^,³, ENSP00000262435⁴	MINT-6504030 I2D: score=1 STRING: ENSP00000262435

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003009	skeletal muscle contraction	IDA	17194691
GO:0030049	muscle filament sliding	TAS	--
GO:0045893	positive regulation of transcription, DNA-dependent	IDA	18331830

TNNI2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNNI2

1 HMDB Compound for TNNI2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about TNNI2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNNI2 gene (3 alternative transcripts):

NM_001145829.1 NM_001145841.1 NM_003282.3

Unigene Cluster for TNNI2:

Troponin I type 2 (skeletal, fast)

Hs.523403 [show with all ESTs]

Unigene Representative Sequence: CF552540

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000381911(uc021qbt.1 uc021qbv.1) ENST00000381906(uc021qbu.1)

ENST00000381905(uc010qxe.1) ENST00000468473 ENST00000252898

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Additional cDNA sequence:

BC032148.2 L21715.1

4 DOTS entries:

DT.445756 DT.120728170 DT.99968414 DT.120728179

24/225 AceView cDNA sequences (see all 225):

F21139 F32101 F26809 F29426 F27802 F25906 F31123 F29237

F24132 F31485 F22811 F31589 AJ572640 F28965 F26563 F30838

F30096 F27640 F16532 F26484 F24773 F26011 F29326 F31532

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TNNI2 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6
SP1:									-
SP2:

ECgene alternative splicing isoforms for TNNI2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNNI2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGGCCGGA

About this image

TNNI2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/15 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 15)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Forelimb Dorsal Muscles

Multinuclear Myocytes

Selective marker (cell-identifying gene)

Skeletal Muscle

Limb

Forelimb Ventral Muscles

Multinuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Dorsal Muscle

Multinuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Ventral Muscle

Multinuclear Myocytes

Skeletal Muscle

Anterior Neck Muscles

Multinuclear Myocytes

Skeletal Muscle

Cervical Back Muscles

Multinuclear Myocytes

Skeletal Muscle

Lumbar Back Muscles

Multinuclear Myocytes

Skeletal Muscle

Lumbar Vertebrae Column Muscles

Multinuclear Myocytes

Skeletal Muscle

Pelvic Muscles

Multinuclear Myocytes

Skeletal Muscle

Posterior Neck Muscles

Multinuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TNNI2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNNI2

SOURCE GeneReport for Unigene cluster: Hs.523403

SABiosciences Expression via Pathway-Focused PCR Arrays including TNNI2:

Angiogenic Growth Factors in human mouse rat

Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TNNI2 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TNNI2¹	troponin I type 2 (skeletal, fast)	77.96(n) 81.11(a)		396386 NM_205417.1 NP_990748.1
lizard (Anolis carolinensis)	Reptilia	TNNI2⁶	--	77(a)	1 ↔ 1	1(70696021-70702004)
African clawed frog (Xenopus laevis)	Amphibia	AF480427.1²	--	82.53(n)		AF480427.1
zebrafish (Danio rerio)	Actinopterygii	AF425744.1²	--	79.59(n)		AF425744.1
fruit fly (Drosophila melanogaster)	Insecta	wupA⁶	wings up A	17(a)	1 → many	X(17999586-18010855)
worm (Caenorhabditis elegans)	Secernentea	unc-27⁶ tni-4⁶ (see all 4)	Troponin I 4 (see all 4)	20(a) 20(a) (see all 4)	many ↔ many many ↔ many (see all 4)	X(8789401-8790568) IV(5204583-5207130)

ENSEMBL Gene Tree for TNNI2 (if available)
TreeFam Gene Tree for TNNI2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TNNI2 gene

TNNI1² TNNI3²

2 SIMAP similar genes for TNNI2 using alignment to 1 protein entry: TNNI2_HUMAN:

TNNI3 TNNI1

TNNI2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs104894312^1,2	C	pathogenic	1653597(+)	`ACCTGC/TGAGAC`	6	R *	stg¹		0	--	--	--	--
rs104894311^1,2	C	pathogenic	1653652(+)	`GGGCCA/GGAAGA`	6	Q R	mis¹		0	--	--	--	--
rs2292476^1,2	C,H	untested	1652005(+)	`GGGCTC/GAAAAC`	3	--	int¹ us2k¹		5		EA NS	1912
rs2271441^1,2	C,F,H	untested	1652811(+)	`ACCCCG/ACCTCC`	3	--	int¹		10		EA NS NA CSA WA EU	1674
rs1877444^1,2	C,F,A,H	untested	1861225(+)	`ACCCAC/ACCACC`	3	--	us2k¹ int¹		17		EA NS NA	1614
rs907610^1,2	C,F,H	untested	1861760(+)	`CAGAGA/C/G/T GTGAT`	12	R S	mis¹ syn¹		17		NA EA MN CSA WA	3411
rs112992909^1,2		--	1649702(+)	`GGCCCG/ACTCAC`	2	--	us2k¹		1		CSA	2
rs11041385^1,2	C,F	--	1650225(+)	`AGTCAC/TGGTCC`	2	--	us2k¹ tfbs³		1		NA	120
rs71471673^1,2	C,F	--	1650248(+)	`CAGGGC/TGGGGG`	2	--	us2k¹		2		NA	4
rs12288321^1,2	F	--	1650509(+)	`GGCAGG/AAAGAT`	3	--	us2k¹		2		CSA	4

HapMap Linkage Disequilibrium report for TNNI2 (1860219 - 1862910 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TNNI2
4 CNVs: 29889 29892 29893 29890
Human Gene Mutation Database (HGMD): TNNI2

Locus Specific Mutation Databases (LSDB): TNNI2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TNNI2 for disorders           About GeneDecksing

OMIM gene information: 191043
OMIM disorders: 601680
UniProtKB/Swiss-Prot: TNNI2_HUMAN, P48788

Defects in TNNI2 are a cause of distal arthrogryposis type 2B (DA2B) [MIM:601680]; also known as

arthrogryposis multiplex congenita, distal, type 2B (AMCD2B). DA2B is a form of inherited multiple congenital

contractures. Affected individuals have vertical talus, ulnar deviation in the hands, severe camptodactyly, and a

distinctive face characterized by a triangular shape, prominent nasolabial folds, small mouth and a prominent chin

10 diseases for TNNI2: About MalaCards

distal arthrogryposis arthrogryposis ovarian carcinoma myopathy

fissured tongue carcinoma nemaline myopathy atrial fibrillation

atrophy of testis pharyngitis

5 diseases from the University of Copenhagen DISEASES database for TNNI2:

Distal arthrogryposis Clubfoot Fissured tongue Atrophy of testis

Nemaline myopathy

Human Genome Epidemiology (HuGE) Navigator: TNNI2 (3 documents)

Export disorders for TNNI2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TNNI2 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with TNNI2)

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Structural characterization of the human fast skeletal muscle troponin I gene (TNNI2). (PubMed id 10721725)^{1, 2, 9} Mullen A.J. and Barton P.J.R. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mutations in genes encoding fast-twitch contractile proteins cause distal arthrogryposis syndromes. (PubMed id 12592607)^{1, 2} Sung S.S.... Bamshad M. (2003)
Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast. (PubMed id 9016781)^{1, 3} Tiso N....Danieli G.A. (1997)
Sequencing of a cDNA encoding the human fast-twitch skeletal muscle isoform of troponin I. (PubMed id 8148383)^{1, 2} Zhu L.... Wade R. (1994)
A novel deletion in TNNI2 causes distal arthrogryposis in a large Chinese family with marked variability of expression. (PubMed id 16802141)^{1, 9} Jiang M....Li J. (2006)
Distal arthrogryposis: clinical and genetic findings. (PubMed id 22519952)¹ Kimber E....Tulinius M. (2012)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Expression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscle. (PubMed id 18548613)¹ Moran C.M....Krieg P.A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7136	HGNC: 11946	AceView: TNNI2	Ensembl:ENSG00000130598	euGenes: HUgn7136
ECgene: TNNI2	H-InvDB: TNNI2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TNNI2	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TNNI2

Intellectual Property for TNNI2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TNNI2 gene:
Search GeneIP for patents involving TNNI2

GeneCards and IP:
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TNNI2 Gene

troponin I type 2 (skeletal, fast)

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TNNI2 Gene

troponin I type 2 (skeletal, fast)

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