Aliases for TNNI1 Gene
External Ids for TNNI1 Gene
Previous GeneCards Identifiers for TNNI1 Gene
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNNI1 Gene
TNNI1 (Troponin I1, Slow Skeletal Type) is a Protein Coding gene. Diseases associated with TNNI1 include Atrophy Of Testis and Cardiomyopathy, Familial Hypertrophic. Among its related pathways are Activation of cAMP-Dependent PKA and Striated Muscle Contraction. GO annotations related to this gene include actin binding. An important paralog of this gene is TNNI3.
UniProtKB/Swiss-Prot for TNNI1 Gene
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.