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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TNNI1 Gene

protein-coding GIFtS: 60
GCID: GC01M201372

troponin I type 1 (skeletal, slow)

(Previous names: troponin I, skeletal, slow )

Explore 11 diseases affiliated with
TNNI1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Troponin I Type 1 (Skeletal, Slow)¹ ²
Troponin I, Slow-Twitch Isoform² ³
Troponin I, Skeletal, Slow¹
SSTNI²
TNN1²
Troponin I, Slow Skeletal Muscle²

External Ids:	HGNC: 11945¹	Entrez Gene: 7135²	Ensembl: ENSG00000159173⁷	OMIM: 191042⁵	UniProtKB: P19237³

Export aliases for TNNI1 gene to outside databases

Previous GC identifers: GC01M199081 GC01M196810 GC01M197839 GC01M198661 GC01M198106 GC01M199639 GC01M172539

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNNI1:

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile

apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3

subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit;

blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three

genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are

expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed

exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is

expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle

fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational

changes in actin-myosin complexes. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNNI1_HUMAN, P19237

Function: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers

calcium-sensitivity to striated muscle actomyosin ATPase activity

Gene Wiki entry for TNNI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNNI1 gene promoter:
NF-1 RFX1 AP-4 Evi-1 MZF-1 AREB6 POU2F1 FOXC1 POU2F1a NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNNI1 promoter sequence

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNNI1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31.3 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q31.3

TNNI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNNI1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M201372: view genomic region (about GC identifiers)

Start:	201,372,895 bp from pter	End:	201,398,994 bp from pter
Size:	26,100 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TNNI1_HUMAN, P19237 (See protein sequence)

Recommended Name: Troponin I, slow skeletal muscle

Size: 187 amino acids; 21692 Da

Subunit: Binds to actin and tropomyosin

Secondary accessions: A6NEH3 A8MSJ0 Q659A5 Q6FGS7 Q6FGW1 Q6ICU2 Q86T57 Q96DT9

Explore the universe of human proteins at neXtProt for TNNI1: NX_P19237

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P19237

TNNI1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003272.3

ENSEMBL proteins:

ENSP00000354488 ENSP00000337022 ENSP00000451307 ENSP00000356281 ENSP00000451660

ENSP00000451776

Reactome Protein details: P19237
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005861	troponin complex	NAS	--

TNNI1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNNI1 for domains About GeneDecksing

1 InterPro domain/family:

IPR001978 Troponin

Graphical View of Domain Structure for InterPro Entry P19237

ProtoNet protein and cluster: P19237

1 Blocks protein family: IPB001978 Troponin

UniProtKB/Swiss-Prot: TNNI1_HUMAN, P19237

Similarity: Belongs to the troponin I family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TNNI1_HUMAN, P19237

Function: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers

calcium-sensitivity to striated muscle actomyosin ATPase activity

Genatlas biochemistry entry for TNNI1:

troponin I1,inhibitory subunit,component of the troponin complex forming the calcium-sensitive molecular switch that

regulates striated muscle contraction in response to modifications in intracellular concentration,slow twitch skeletal

muscle,also expressed in cartilage,acting as a potent and specific inhibitor of angiogenesis

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	NAS	--
GO:0005523	tropomyosin binding	NAS	--
GO:0046872	metal ion binding	IEA	--

TNNI1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for TNNI1:

Decreased nuclei size in G2M

Increased S DNA content

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

Striated Muscle Contraction

	Striated Muscle Contraction	1.00			Muscle contraction	0.65
	Striated Muscle Contraction	0.87

Erythropoietin Pathway

Beta-Adrenergic Signaling

0.37

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNNI1

	Activation of PKA through GPCR
	PKA Signaling
	cAMP Pathway
	Activation of cAMP-Dependent PKA
	Beta-Adrenergic Signaling

1 BioSystems Pathway for TNNI1

Striated Muscle Contraction

2 Reactome Pathways for TNNI1

	Muscle contraction
	Striated Muscle Contraction

TNNI1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TNNI1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/39 Interacting proteins for TNNI1 (P19237^{2, 3} ENSP00000337022⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 39)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCDC85B	Q15834²^,³, ENSP00000311695⁴	MINT-66891 I2D: score=5 STRING: ENSP00000311695
ACTA1	P68133³, ENSP00000355645⁴	I2D: score=2 STRING: ENSP00000355645
TNNT1	P13805³, ENSP00000291901⁴	I2D: score=2 STRING: ENSP00000291901
TRIM63	Q969Q1³, ENSP00000363390⁴	I2D: score=1 STRING: ENSP00000363390
TNNC1	P63316³, ENSP00000232975⁴	I2D: score=2 STRING: ENSP00000232975

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006937	regulation of muscle contraction	--	--
GO:0006942	regulation of striated muscle contraction	NAS	2365354
GO:0030049	muscle filament sliding	TAS	--
GO:0055010	ventricular cardiac muscle tissue morphogenesis	IEA	--

TNNI1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for TNNI1

1 HMDB Compound for TNNI1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about TNNI1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNNI1 gene:

NM_003281.3

Unigene Cluster for TNNI1:

Troponin I type 1 (skeletal, slow)

Hs.320890 [show with all ESTs]

Unigene Representative Sequence: NM_003281

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000361379(uc021phd.1 uc001gwo.1) ENST00000336092 ENST00000555948

ENST00000367312(uc021phe.1 uc001gwp.3) ENST00000555340 ENST00000556362

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Additional cDNA sequence:

AJ315823.1 AK123965.1 AK223588.1 AK311896.1 AL831820.1 AL831975.1 AL832006.2 BC012600.1

BC012601.1 CR450301.1 CR541996.1 CR542030.1 J04760.1

19 DOTS entries:

DT.100804228 DT.219939 DT.99997083 DT.95338454 DT.100823769 DT.95264078 DT.95236214 DT.121339071

DT.121339033 DT.121339058 DT.40117493 DT.91710453 DT.91710539 DT.95338448 DT.95338455 DT.100819279

DT.100823768 DT.100823771 DT.121339034

24/477 AceView cDNA sequences (see all 477):

F35574 AJ346745 F20558 F29330 AJ345997 F30910 F17510 F18054

F25818 F27355 F26931 F29944 F22401 F35653 F17371 F16078

F24966 F21783 F26477 F32733 F32527 F29334 AJ572973 F15745

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TNNI1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b
SP1:																									-
SP2:															-		-		-		-				-
SP3:
SP4:									-		-
SP5:

ECgene alternative splicing isoforms for TNNI1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNNI1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGCACCTGG

About this image

TNNI1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/20 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 20)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Forelimb Dorsal Muscles

Multinuclear Myocytes

Selective marker (cell-identifying gene)

Skeletal Muscle

Limb

Forelimb Ventral Muscles

Multinuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Dorsal Muscle

Multinuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Ventral Muscle

Multinuclear Myocytes

Skeletal Muscle

Anterior Neck Muscles

Multinuclear Myocytes

Skeletal Muscle

Cervical Back Muscles

Multinuclear Myocytes

Skeletal Muscle

Lumbar Back Muscles

Multinuclear Myocytes

Skeletal Muscle

Lumbar Vertebrae Column Muscles

Multinuclear Myocytes

Skeletal Muscle

Pelvic Muscles

Multinuclear Myocytes

Skeletal Muscle

Posterior Neck Muscles

Multinuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See TNNI1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNNI1

SOURCE GeneReport for Unigene cluster: Hs.320890

UniProtKB/Swiss-Prot: TNNI1_HUMAN, P19237

Tissue specificity: Highest levels observed in human skeletal muscle (e.g. gastrocnemious muscle), differentiated

cultures of primary human muscle cells and rhabdomyosarcoma cells cultured in low serum medium. Expressed in C2 muscle

cell myoblasts and myotubes

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TNNI1 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TNNI1¹	troponin I type 1 (skeletal, slow)	80.75(n) 88.77(a)		421161 XM_419242.3 XP_419242.3
lizard (Anolis carolinensis)	Reptilia	TNNI1⁶	--	87(a)	1 ↔ 1	4(131463834-131469680)
African clawed frog (Xenopus laevis)	Amphibia	LOC397803²	cardiac troponin I	77.86(n)		L25721.1
zebrafish (Danio rerio)	Actinopterygii	tnni1b¹	troponin I, skeletal, slow b	74.73(n) 79.12(a)		494070 NM_001008613.1 NP_001008613.1
fruit fly (Drosophila melanogaster)	Insecta	wupA⁶	wings up A	17(a)	1 → many	X(17999586-18010855)
worm (Caenorhabditis elegans)	Secernentea	tni-4⁶ unc-27⁶ (see all 4)	Troponin I 2 (see all 4)	24(a) 21(a) (see all 4)	many ↔ many many ↔ many (see all 4)	IV(5204583-5207130) X(8789401-8790568)

ENSEMBL Gene Tree for TNNI1 (if available)
TreeFam Gene Tree for TNNI1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TNNI1 gene

TNNI2² TNNI3²

2 SIMAP similar genes for TNNI1 using alignment to 4 protein entries: TNNI1_HUMAN (see all proteins):

TNNI2 TNNI3

TNNI1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12059752^1,2	C,F,A,H	--	172538503(+)	`ACATTT/AGGAAG`	1	--	ds500¹		14		NS EA NA WA	1634
rs191950319^1,2	C	--	172539605(+)	`GCTTTC/TGGTTT`	1	--	ut3¹		0	--	--	--	--
rs115467535^1,2	C,F	--	172539874(+)	`CAGTTG/AAAATT`	1	--	ut3¹		1		NA	120
rs6656471^1,2	H	--	172540871(+)	`CTTGCG/ACCGTG`	1	--	ut3¹ ese³		4		NS EA	420
rs12126795^1,2	H	--	172541377(+)	`ttgaaC/Ttctcc`	1	--	ut3¹		4		NS EA	418
rs58932365^1,2	C	--	172541395(+)	`CATTT-/CCTCATC TGTAAATTTGAGCTA`	2	--	ut3¹		0	--	--	--	--
rs201338296^1,2	C	--	172541395(+)	`CATTTA/CCNNNN`	1	--	ut3¹		0	--	--	--	--
rs75128624^1,2	F	--	172541657(+)	`TTTCTC/GCTAGG`	1	--	ut3¹		1		WA	118
rs116649880^1,2	C,F	--	172541830(+)	`GGCCAG/AGCCCC`	1	--	ut3¹		1		WA	118
rs78739506^1,2	C,F	--	172542358(+)	`GGAAGA/GGTGGG`	1	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for TNNI1 (201372895 - 201398994 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TNNI1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TNNI1 for disorders           About GeneDecksing

OMIM gene information: 191042    OMIM disorders: --

11 diseases for TNNI1:    About MalaCards

myocardial infarction atrial fibrillation acute myocardial infarction atrophy of testis

hypertrophic cardiomyopathy cardiomyopathy rhabdomyosarcoma seizures

pharyngitis anemia dilated cardiomyopathy

2 diseases from the University of Copenhagen DISEASES database for TNNI1:

Atrophy of testis Hypertrophic cardiomyopathy

Export disorders for TNNI1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TNNI1 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with TNNI1)

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world of online information

Structure and expression of the human slow twitch skeletal muscle troponin I gene. (PubMed id 8144655)^{1, 2, 3} Corin S.J....Wade R. (1994)
cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I. (PubMed id 2365354)^{1, 2, 3} Wade R.... Kedes L. (1990)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Troponin I isoform expression in human heart. (PubMed id 1934363)^{1, 9} Hunkeler N.M.... Murphy A.M. (1991)
hMusTRD1alpha1 represses MEF2 activation of the troponin I slow enhancer. (PubMed id 12857748)^{1, 9} Polly P....Hardeman E.C. (2003)
Cardiac biomarkers are associated with an increased ri sk of stroke and death in patients with atrial fibrillation: a Randomized Evalua tion of Long-term Anticoagulation Therapy (RE-LY) substudy. (PubMed id 22374183)¹ Hijazi Z....Wallentin L. (2012)
Analysis of the sarcomere protein gene mutation on ca rdiomyopathy - Mutations in the cardiac troponin I gene. (PubMed id 20817590)¹ Murakami C....Kurihara K. (2010)
Impact of troponin 1 on long-term mortality after eme rgency orthopaedic surgery in older patients. (PubMed id 19811558)¹ Chong C....Lim W.K. (2010)
The Ubiquitin-interacting Motif Protein, S5a, Is Ubiquitinated by All Types of Ubiquitin Ligases by a Mechanism Different from Typical Substrate Recognition. (PubMed id 19240029)¹ Uchiki T....Goldberg A.L. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7135	HGNC: 11945	AceView: TNNI1	Ensembl:ENSG00000159173	euGenes: HUgn7135
ECgene: TNNI1	H-InvDB: TNNI1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TNNI1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TNNI1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TNNI1 gene:
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GeneCards and IP:
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TNNI1 Gene

troponin I type 1 (skeletal, slow)

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TNNI1 Gene

troponin I type 1 (skeletal, slow)

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