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TNNI1 Gene

protein-coding   GIFtS: 62
GCID: GC01M201372

Troponin I Type 1 (Skeletal, Slow)

(Previous names: troponin I, skeletal, slow)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Troponin I Type 1 (Skeletal, Slow)1 2
Troponin I, Slow-Twitch Isoform2 3
Troponin I, Skeletal, Slow1
SSTNI2
TNN12
Troponin I, Slow Skeletal Muscle2

External Ids:    HGNC: 119451   Entrez Gene: 71352   Ensembl: ENSG000001591737   OMIM: 1910425   UniProtKB: P192373   

Export aliases for TNNI1 gene to outside databases

Previous GC identifers: GC01M199081 GC01M196810 GC01M197839 GC01M198661 GC01M198106 GC01M199639 GC01M172539


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNNI1 Gene:
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile
apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3
subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit;
blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains
three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes
are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is
expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein.
This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch
skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated
conformational changes in actin-myosin complexes. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNNI1 Gene:
TNNI1 (troponin I type 1 (skeletal, slow)) is a protein-coding gene. Diseases associated with TNNI1 include atrophy of testis, and hypertrophic cardiomyopathy. GO annotations related to this gene include actin binding and tropomyosin binding. An important paralog of this gene is TNNI2.

UniProtKB/Swiss-Prot: TNNI1_HUMAN, P19237
Function: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers
calcium-sensitivity to striated muscle actomyosin ATPase activity

Gene Wiki entry for TNNI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNNI1 gene promoter:
         NF-1   RFX1   AP-4   Evi-1   MZF-1   AREB6   POU2F1   FOXC1   POU2F1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNNI1 promoter sequence
   Search Chromatin IP Primers for TNNI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNNI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31.3   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31.3

TNNI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNNI1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M201372:  view genomic region     (about GC identifiers)

Start:
201,372,895 bp from pter      End:
201,398,994 bp from pter
Size:
26,100 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TNNI1_HUMAN, P19237 (See protein sequence)
Recommended Name: Troponin I, slow skeletal muscle  
Size: 187 amino acids; 21692 Da
Subunit: Binds to actin and tropomyosin
Secondary accessions: A6NEH3 A8MSJ0 Q659A5 Q6FGS7 Q6FGW1 Q6ICU2 Q86T57 Q96DT9

Explore the universe of human proteins at neXtProt for TNNI1: NX_P19237

Explore proteomics data for TNNI1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TNNI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003272.3  
    ENSEMBL proteins: 
     ENSP00000354488   ENSP00000337022   ENSP00000451307   ENSP00000356281   ENSP00000451660  
     ENSP00000451776  
    Reactome Protein details: P19237

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001978 Troponin

    Graphical View of Domain Structure for InterPro Entry P19237

    ProtoNet protein and cluster: P19237

    1 Blocks protein domain: IPB001978 Troponin

    UniProtKB/Swiss-Prot: TNNI1_HUMAN, P19237
    Similarity: Belongs to the troponin I family


    TNNI1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNNI1_HUMAN, P19237
    Function: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers
    calcium-sensitivity to striated muscle actomyosin ATPase activity

         Genatlas biochemistry entry for TNNI1:
    troponin I1,inhibitory subunit,component of the troponin complex forming the calcium-sensitive molecular switch
    that regulates striated muscle contraction in response to modifications in intracellular concentration,slow
    twitch skeletal muscle,also expressed in cartilage,acting as a potent and specific inhibitor of angiogenesis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005523tropomyosin binding ----
    GO:0046872metal ion binding IEA--
         
    TNNI1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNNI1:
     Decreased nuclei size in G2M  Increased S DNA content 

    Animal Models:
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    miRTarBase miRNAs that target TNNI1:
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    Block miRNA regulation of human, mouse, rat TNNI1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNNI1 (see all 34):
    hsa-miR-1224-3p hsa-miR-629 hsa-miR-4325 hsa-miR-647 hsa-miR-4289 hsa-miR-492 hsa-miR-409-3p hsa-miR-627
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005861troponin complex IEA--

    TNNI1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNNI1 About    
    See pathways by source

    SuperPathContained pathways About
    1Striated Muscle Contraction
    Striated Muscle Contraction0.82
    Muscle contraction0.61
    Striated Muscle Contraction0.82
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    3Beta-Adrenergic Signaling
    Beta-Adrenergic Signaling0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNNI1
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA
    Beta-Adrenergic Signaling

    1 BioSystems Pathway for TNNI1
        Striated Muscle Contraction


    1 Reactome Pathway for TNNI1
        Striated Muscle Contraction



    TNNI1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TNNI1
    Interactions:

        Search GeneGlobe Interaction Network for TNNI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNNI1 (P192372, 3 ENSP000003370224) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-66891 I2D: score=5 STRING: ENSP00000311695
    ACTA1P681333, ENSP000003556454I2D: score=2 STRING: ENSP00000355645
    TNNT1P138053, ENSP000002919014I2D: score=2 STRING: ENSP00000291901
    TRIM63Q969Q13, ENSP000003633904I2D: score=1 STRING: ENSP00000363390
    TNNC1P633163, ENSP000002329754I2D: score=2 STRING: ENSP00000232975
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006942regulation of striated muscle contraction NAS2365354
    GO:0030049muscle filament sliding TAS--
    GO:0055010ventricular cardiac muscle tissue morphogenesis IEA--

    TNNI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNNI1

    1 HMDB Compound for TNNI1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TNNI1 gene: 
    NM_003281.3  

    Unigene Cluster for TNNI1:

    Troponin I type 1 (skeletal, slow)
    Hs.320890  [show with all ESTs]
    Unigene Representative Sequence: NM_003281
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361379(uc021phd.1 uc001gwo.1) ENST00000336092 ENST00000555948
    ENST00000367312(uc021phe.1 uc001gwp.3) ENST00000555340 ENST00000556362

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    Selected qRT-PCR Assays for microRNAs that regulate TNNI1 (see all 34):
    hsa-miR-1224-3p hsa-miR-629 hsa-miR-4325 hsa-miR-647 hsa-miR-4289 hsa-miR-492 hsa-miR-409-3p hsa-miR-627
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      QuantiFast Probe-based Assays in human, mouse, rat TNNI1

    Additional mRNA sequence: 

    AJ315823.1 AK123965.1 AK223588.1 AK311896.1 AL831820.1 AL831975.1 AL832006.2 BC012600.1 
    BC012601.1 CR450301.1 CR541996.1 CR542030.1 J04760.1 

    19 DOTS entries:

    DT.100804228  DT.219939  DT.99997083  DT.95338454  DT.100823769  DT.95264078  DT.95236214  DT.121339071 
    DT.121339033  DT.121339058  DT.40117493  DT.91710453  DT.91710539  DT.95338448  DT.95338455  DT.100819279 
    DT.100823768  DT.100823771  DT.121339034 

    Selected AceView cDNA sequences (see all 477):

    F28992 F18054 F29334 F25895 F28003 F28429 AA192956 AJ346745 
    AJ574562 F22401 F27355 F35653 F28541 F30910 F37572 F28736 
    F29450 F30322 F17536 F28613 F17510 F32733 F30333 F29330 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TNNI1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
    SP1:                                                                          -               
    SP2:                                            -     -     -     -           -               
    SP3:                                                                                          
    SP4:                          -     -                                                         
    SP5:                                                                                          


    ECgene alternative splicing isoforms for TNNI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNNI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCACCTGG
    TNNI1 Expression
    About this image


    TNNI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 16 entries
             Multinuclear Myocytes Lumbar Back Muscles
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
     
     Heart (Cardiovascular System)    fully expand to see all 6 entries
             Cardiac Crescent Cells Cardiac Crescent
             Heart Tube
             Cardiomyocyte-like progenitor cells
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    TNNI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNNI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.320890

    UniProtKB/Swiss-Prot: TNNI1_HUMAN, P19237
    Tissue specificity: Highest levels observed in human skeletal muscle (e.g. gastrocnemious muscle), differentiated
    cultures of primary human muscle cells and rhabdomyosarcoma cells cultured in low serum medium. Expressed in C2
    muscle cell myoblasts and myotubes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNNI1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnni11 , 5 troponin I, skeletal, slow 11, 5 89.66(n)1
    97.86(a)1
      1 (59.28 cM)5
    219521  NM_001112702.11  NP_001106173.11 
     1357830655 
    chicken
    (Gallus gallus)
    Aves TNNI11 troponin I type 1 (skeletal, slow) 80.75(n)
    88.77(a)
      421161  XM_004934839.1  XP_004934896.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNNI16
    troponin I type 1 (skeletal, slow)
    87(a)
    1 ↔ 1
    4(131460969-131469155)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978032 cardiac troponin I 77.86(n)    L25721.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tnni1b1 troponin I, skeletal, slow b 74.73(n)
    79.12(a)
      494070  NM_001008613.1  NP_001008613.1 


    ENSEMBL Gene Tree for TNNI1 (if available)
    TreeFam Gene Tree for TNNI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNNI1 gene
    TNNI22  TNNI32  
    2 SIMAP similar genes for TNNI1 using alignment to 4 protein entries:     TNNI1_HUMAN (see all proteins):
    TNNI2    TNNI3

    TNNI1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNNI1 (see all 462)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57800681,2
    C,F--201384704(+) TAGGA-/CCCCCC 1 -- int1 trp33Minor allele frequency- C:0.33NA CSA 6
    rs38356011,2
    C--201388613(+) GTGTG-/GT/TG 
            
    GAGTG
    1 -- int10--------
    rs1168016391,2
    C,F--207909903(+) TGGAAA/CGAACA 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1810629451,2
    --207909927(+) AGCCTA/GAGAGC 1 -- ds50010--------
    rs120597521,2
    C,F,A,H--207909952(+) ACATTT/AGGAAG 1 -- ds500114Minor allele frequency- A:0.11NS EA NA WA 1634
    rs1477785481,2
    C--207910142(+) GGGTAA/GAGAAG 1 -- ds50010--------
    rs1859276581,2
    --207910174(+) AGTGAA/GACTCA 1 -- ds50010--------
    rs27996811,2
    C,F,O,A,H--207910186(-) TTTGAA/GTATTC 1 -- ds500136Minor allele frequency- N:0.00EA NA NS WA CSA 3351
    rs1411076741,2
    --207910228(+) TGTCTA/GTCAGC 1 -- ds50010--------
    rs1469679861,2
    --207910230(+) TCTATC/TAGCAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TNNI1 (201372895 - 201398994 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TNNI1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4065CNV Insertion18451855
    nsv508687CNV Loss20534489
    nsv832326CNV Loss17160897
    nsv522795CNV Loss19592680
    nsv832315CNV Loss17160897
    nsv467961CNV Gain19166990
    nsv470776CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNNI1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 191042    OMIM disorders: --

    9 diseases for TNNI1:    
    About MalaCards
    atrophy of testis    hypertrophic cardiomyopathy    acute myocardial infarction    dilated cardiomyopathy
    rhabdomyosarcoma    myocardial infarction    asthma    cervicitis
    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for TNNI1:
    Atrophy of testis     Hypertrophic cardiomyopathy

    TNNI1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TNNI1

    Export disorders for TNNI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNNI1 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with TNNI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of the human slow twitch skeletal muscle troponin I gene. (PubMed id 8144655)1, 2, 3 Corin S.J.... Wade R. (J. Biol. Chem. 1994)
    2. cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I. (PubMed id 2365354)1, 2, 3 Wade R.... Kedes L. (Genomics 1990)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Troponin I isoform expression in human heart. (PubMed id 1934363)1, 9 Hunkeler N.M.... Murphy A.M. (Circ. Res. 1991)
    6. hMusTRD1alpha1 represses MEF2 activation of the troponin I slow enhancer. (PubMed id 12857748)1, 9 Polly P....Hardeman E.C. (J. Biol. Chem. 2003)
    7. Cardiac biomarkers are associated with an increased risk of stroke and death in patients with atrial fibrillation: a Randomized Evaluation of Long-term Anticoagulation Therapy (RE-LY) substudy. (PubMed id 22374183)1 Hijazi Z....Wallentin L. (Circulation 2012)
    8. Serum skeletal troponin I following inspiratory threshold loading in healthy young and middle-aged men. (PubMed id 22323298)1 Foster G.E....Reid W.D. (Eur. J. Appl. Physiol. 2012)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Analysis of the sarcomere protein gene mutation on cardiomyopathy - Mutations in the cardiac troponin I gene. (PubMed id 20817590)1 Murakami C....Kurihara K. (Leg Med (Tokyo) 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7135 HGNC: 11945 AceView: TNNI1 Ensembl:ENSG00000159173 euGenes: HUgn7135
    ECgene: TNNI1 H-InvDB: TNNI1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNNI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNNI1 gene:
    Search GeneIP for patents involving TNNI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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