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Aliases for TNNI1 Gene

Aliases for TNNI1 Gene

  • Troponin I1, Slow Skeletal Type 2 3
  • Troponin I Type 1 (Skeletal, Slow) 2 3 5
  • Troponin I, Slow-Twitch Isoform 3 4
  • SSTNI 3
  • TNN1 3

External Ids for TNNI1 Gene

Previous GeneCards Identifiers for TNNI1 Gene

  • GC01M199081
  • GC01M196810
  • GC01M197839
  • GC01M198661
  • GC01M198106
  • GC01M199639
  • GC01M201372
  • GC01M172539

Summaries for TNNI1 Gene

Entrez Gene Summary for TNNI1 Gene

  • Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNNI1 Gene

TNNI1 (Troponin I1, Slow Skeletal Type) is a Protein Coding gene. Diseases associated with TNNI1 include Atrophy Of Testis. Among its related pathways are Activation of cAMP-Dependent PKA and Striated Muscle Contraction. GO annotations related to this gene include actin binding. An important paralog of this gene is TNNI2.

UniProtKB/Swiss-Prot for TNNI1 Gene

  • Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Gene Wiki entry for TNNI1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNNI1 Gene

Genomics for TNNI1 Gene

Regulatory Elements for TNNI1 Gene

Enhancers for TNNI1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TNNI1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNNI1 Gene

201,403,767 bp from pter
201,429,866 bp from pter
26,100 bases
Minus strand

Genomic View for TNNI1 Gene

Genes around TNNI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNNI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNNI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNNI1 Gene

Proteins for TNNI1 Gene

  • Protein details for TNNI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Troponin I, slow skeletal muscle
    Protein Accession:
    Secondary Accessions:
    • A6NEH3
    • A8MSJ0
    • Q659A5
    • Q6FGS7
    • Q6FGW1
    • Q6ICU2
    • Q86T57
    • Q96DT9

    Protein attributes for TNNI1 Gene

    187 amino acids
    Molecular mass:
    21692 Da
    Quaternary structure:
    • Binds to actin and tropomyosin.

neXtProt entry for TNNI1 Gene

Proteomics data for TNNI1 Gene at MOPED

Post-translational modifications for TNNI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNNI1 Gene

No data available for DME Specific Peptides for TNNI1 Gene

Domains & Families for TNNI1 Gene

Gene Families for TNNI1 Gene

Protein Domains for TNNI1 Gene


Suggested Antigen Peptide Sequences for TNNI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the troponin I family.
  • Belongs to the troponin I family.
genes like me logo Genes that share domains with TNNI1: view

Function for TNNI1 Gene

Molecular function for TNNI1 Gene

GENATLAS Biochemistry:
troponin I1,inhibitory subunit,component of the troponin complex forming the calcium-sensitive molecular switch that regulates striated muscle contraction in response to modifications in intracellular concentration,slow twitch skeletal muscle,also expressed in cartilage,acting as a potent and specific inhibitor of angiogenesis
UniProtKB/Swiss-Prot Function:
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Gene Ontology (GO) - Molecular Function for TNNI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with TNNI1: view
genes like me logo Genes that share phenotypes with TNNI1: view

Animal Model Products

miRNA for TNNI1 Gene

miRTarBase miRNAs that target TNNI1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNNI1 Gene

Localization for TNNI1 Gene

Subcellular locations from

Jensen Localization Image for TNNI1 Gene COMPARTMENTS Subcellular localization image for TNNI1 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TNNI1 Gene

Pathways & Interactions for TNNI1 Gene

genes like me logo Genes that share pathways with TNNI1: view

Pathways by source for TNNI1 Gene

Gene Ontology (GO) - Biological Process for TNNI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003009 skeletal muscle contraction IBA --
GO:0006937 regulation of muscle contraction IEA --
GO:0060048 cardiac muscle contraction IBA --
genes like me logo Genes that share ontologies with TNNI1: view

No data available for SIGNOR curated interactions for TNNI1 Gene

Drugs & Compounds for TNNI1 Gene

(1) Drugs for TNNI1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with TNNI1: view

Transcripts for TNNI1 Gene

mRNA/cDNA for TNNI1 Gene

Unigene Clusters for TNNI1 Gene

Troponin I type 1 (skeletal, slow):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNNI1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
SP1: -
SP2: - - - - -
SP4: - -

Relevant External Links for TNNI1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNNI1 Gene

mRNA expression in normal human tissues for TNNI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNNI1 Gene

This gene is overexpressed in Muscle - Skeletal (x50.1).

Protein differential expression in normal tissues from HIPED for TNNI1 Gene

This gene is overexpressed in Fetal heart (51.8) and Esophagus (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNNI1 Gene

SOURCE GeneReport for Unigene cluster for TNNI1 Gene Hs.320890

mRNA Expression by UniProt/SwissProt for TNNI1 Gene

Tissue specificity: Highest levels observed in human skeletal muscle (e.g. gastrocnemious muscle), differentiated cultures of primary human muscle cells and rhabdomyosarcoma cells cultured in low serum medium. Expressed in C2 muscle cell myoblasts and myotubes.
genes like me logo Genes that share expression patterns with TNNI1: view

Protein tissue co-expression partners for TNNI1 Gene

- Elite partner

Primer Products

Orthologs for TNNI1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNNI1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNNI1 35
  • 90.73 (n)
  • 97.33 (a)
TNNI1 36
  • 97 (a)
(Canis familiaris)
Mammalia TNNI1 35
  • 92.16 (n)
  • 97.86 (a)
TNNI1 36
  • 98 (a)
(Mus musculus)
Mammalia Tnni1 35
  • 89.66 (n)
  • 97.86 (a)
Tnni1 16
Tnni1 36
  • 98 (a)
(Pan troglodytes)
Mammalia TNNI1 35
  • 99.29 (n)
  • 100 (a)
TNNI1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tnni1 35
  • 90.02 (n)
  • 97.33 (a)
(Monodelphis domestica)
Mammalia TNNI1 36
  • 96 (a)
(Gallus gallus)
Aves TNNI1 35
  • 80.75 (n)
  • 88.77 (a)
TNNI1 36
  • 77 (a)
(Anolis carolinensis)
Reptilia TNNI1 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100125108 35
  • 69.88 (n)
  • 80.75 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397803 35
(Danio rerio)
Actinopterygii tnni1b 35
  • 74.73 (n)
  • 79.12 (a)
tnni1a 36
  • 77 (a)
tnni1b 36
  • 68 (a)
tnni1d 36
  • 60 (a)
tnni1d 36
  • 60 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13140 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11013 36
  • 44 (a)
Species with no ortholog for TNNI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNNI1 Gene

Gene Tree for TNNI1 (if available)
Gene Tree for TNNI1 (if available)

Paralogs for TNNI1 Gene

Paralogs for TNNI1 Gene

(2) SIMAP similar genes for TNNI1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TNNI1: view

Variants for TNNI1 Gene

Sequence variations from dbSNP and Humsavar for TNNI1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2296695 - 201,413,112(+) CTCCC(A/C/G)GCACA reference, missense
rs1107256 -- 201,404,716(+) GTGGA(A/G)CAGTT utr-variant-3-prime
rs1022972 -- 201,412,475(+) TTCTC(C/T)GCTCT intron-variant
rs1138431 -- 201,409,959(-) gcctt(C/T)taggt intron-variant
rs1051895 -- 201,409,005(-) GGCTT(C/T)TCAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TNNI1 Gene

Variant ID Type Subtype PubMed ID
nsv467961 CNV Gain 19166990
nsv470776 CNV Gain 18288195
nsv832315 CNV Loss 17160897
nsv832326 CNV Loss 17160897
nsv508687 CNV Loss 20534489
nsv4065 CNV Insertion 18451855
nsv522795 CNV Loss 19592680

Variation tolerance for TNNI1 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TNNI1 Gene

Disorders for TNNI1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TNNI1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
atrophy of testis
- elite association - COSMIC cancer census association via MalaCards
Search TNNI1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TNNI1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TNNI1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNNI1 Gene

Publications for TNNI1 Gene

  1. Structure and expression of the human slow twitch skeletal muscle troponin I gene. (PMID: 8144655) Corin S.J. … Wade R. (J. Biol. Chem. 1994) 2 3 4 67
  2. hMusTRD1alpha1 represses MEF2 activation of the troponin I slow enhancer. (PMID: 12857748) Polly P. … Hardeman E.C. (J. Biol. Chem. 2003) 3 23
  3. Troponin I isoform expression in human heart. (PMID: 1934363) Hunkeler N.M. … Murphy A.M. (Circ. Res. 1991) 3 23
  4. cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I. (PMID: 2365354) Wade R. … Kedes L. (Genomics 1990) 2 3
  5. Whole exome sequencing identifies the TNNI3K gene as a cause of familial conduction system disease and congenital junctional ectopic tachycardia. (PMID: 25791106) Xi Y. … Gow R.M. (Int. J. Cardiol. 2015) 3

Products for TNNI1 Gene

Sources for TNNI1 Gene