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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNNC2 Gene

protein-coding   GIFtS: 57
GCID: GC20M044451

Troponin C Type 2 (Fast)

(Previous names: troponin C2, fast)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Troponin C Type 2 (Fast)1 2
Troponin C2, Fast1 2
Troponin C, Skeletal Muscle2

External Ids:    HGNC: 119441   Entrez Gene: 71252   Ensembl: ENSG000001014707   OMIM: 1910395   UniProtKB: P025853   

Export aliases for TNNC2 gene to outside databases

Previous GC identifers: GC20M044180 GC20M044140 GC20M045090 GC20M045137 GC20M043885 GC20M041193


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNNC2 Gene:
Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits.
The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit
binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded
by this gene is the Tn-C subunit. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNNC2 Gene: 
TNNC2 (troponin C type 2 (fast)) is a protein-coding gene. Diseases associated with TNNC2 include distal arthrogryposis, and clubfoot, and among its related super-pathways are Striated Muscle Contraction. GO annotations related to this gene include actin binding and calcium ion binding. An important paralog of this gene is CALML3.

UniProtKB/Swiss-Prot: TNNC2_HUMAN, P02585
Function: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three
components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for
tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments

Gene Wiki entry for TNNC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNNC2 gene promoter:
         Egr-3   Max1   AhR   MyoD   Lmo2   Arnt   Egr-2   HFH-1   Msx-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNNC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNNC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNNC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.11   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12-q13.11

TNNC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNNC2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M044451:  view genomic region     (about GC identifiers)

Start:
44,451,853 bp from pter      End:
44,462,384 bp from pter
Size:
10,532 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNNC2_HUMAN, P02585 (See protein sequence)
Recommended Name: Troponin C, skeletal muscle  
Size: 160 amino acids; 18122 Da
Miscellaneous: Skeletal muscle troponin C binds four calcium ions

Explore the universe of human proteins at neXtProt for TNNC2: NX_P02585

Explore proteomics data for TNNC2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P02585

  • TNNC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNNC2 Protein Expression
    REFSEQ proteins: NP_003270.1  
    ENSEMBL proteins: 
     ENSP00000361636   ENSP00000361638  
    Reactome Protein details: P02585
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    Cloud-Clone Corp. Proteins for TNNC2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005829cytosol TAS--
    GO:0005861troponin complex IDA17194691

    TNNC2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR018247 EF_Hand_1_Ca_BS
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry P02585

    ProtoNet protein and cluster: P02585

    UniProtKB/Swiss-Prot: TNNC2_HUMAN, P02585
    Similarity: Belongs to the troponin C family
    Similarity: Contains 4 EF-hand domains


    TNNC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNNC2_HUMAN, P02585
    Function: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three
    components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for
    tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments

         Genatlas biochemistry entry for TNNC2:
    troponin C2,calcium binding subunit,component of the troponin complex forming the calcium-sensitive molecular
    switch that regulates striated muscle contraction in response to modifications in intracellular
    concentration,fast twitch skeletal muscle

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779contributes to actin binding IDA17194691
    GO:0005509calcium ion binding IEA--
         
    TNNC2 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNNC2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Striated Muscle Contraction
    Striated Muscle Contraction0.87
    Muscle contraction0.65
    Striated Muscle Contraction0.87
    2Calcium signaling pathway
    Calcium signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TNNC2
        Striated Muscle Contraction

    2        Reactome Pathways for TNNC2
        Muscle contraction
    Striated Muscle Contraction


    1         Kegg Pathway  (Kegg details for TNNC2):
        Calcium signaling pathway


    TNNC2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TNNC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for TNNC2 (P025853 ENSP000003616364) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNNI2P487883, ENSP000002528984I2D: score=1 STRING: ENSP00000252898
    ACTN2ENSP000003555374STRING: ENSP00000355537
    DESENSP000003630714STRING: ENSP00000363071
    MYBPC1ENSP000003548494STRING: ENSP00000354849
    MYBPC2ENSP000003503324STRING: ENSP00000350332
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003009skeletal muscle contraction IDA17194691
    GO:0006937regulation of muscle contraction TAS2373703
    GO:0007165signal transduction ----
    GO:0030049muscle filament sliding TAS--

    TNNC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNNC2

    1 HMDB Compound for TNNC2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for TNNC2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Calcium-- --targetagonist20371872 20801130 21250664 21035455
    FelodipineDl-Felodipine (see all 4)72509-76-3targetother3178884 10592235
    Octylphenoxy polyethoxyethanolalkylphenol-hydroxypolyoxyetheylene (see all 2)9036-19-5target--10592235

    Search CenterWatch for drugs/clinical trials and news about TNNC2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNNC2 gene: 
    NM_003279.2  

    Unigene Cluster for TNNC2:

    Troponin C type 2 (fast)
    Hs.182421  [show with all ESTs]
    Unigene Representative Sequence: BF574800
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372555(uc002xpr.3) ENST00000372557
    miRNA
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    Additional mRNA sequence: 

    AK291323.1 AK300665.1 BC005323.1 CR541864.1 CR541884.1 M22307.1 X07898.1 

    14 DOTS entries:

    DT.101985358  DT.120817722  DT.119490  DT.120817136  DT.120817198  DT.95277780  DT.100023184  DT.120817210 
    DT.120817835  DT.120817685  DT.120817575  DT.95280722  DT.102835624  DT.95081953 

    24/326 AceView cDNA sequences (see all 326):

    F29034 F31168 F24226 AA442911 F29196 NM_003279 AA176669 F19002 
    F37203 F26105 F26680 F29981 F27658 F26352 F36192 F34343 
    AA176750 F26530 F30072 F22622 F30437 F29162 F19531 F33636 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNNC2 expression in normal human tissues (normalized intensities)      TNNC2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGTGCGCC
    TNNC2 Expression
    About this image


    TNNC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 23 entries
             Multinuclear Myocytes Thoracic Vertebral Column Muscles
             skeletal muscle ; myocytes   
             cavities and their linings/intraembryonic coelom/diaphragm   
     
     Limb (Muscoskeletal System)    fully expand to see all 10 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
             Autopod
             limb/hindlimb/hind-paw   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut

    See TNNC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNNC2

    SOURCE GeneReport for Unigene cluster: Hs.182421
        SABiosciences Custom PCR Arrays for TNNC2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TNNC2 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnnc21 , 5 troponin C2, fast1, 5 90.21(n)1
    98.75(a)1
      2 (85.27 cM)5
    219251  NM_009394.21  NP_033420.11 
     1647771615 
    chicken
    (Gallus gallus)
    Aves TNNC21 troponin C type 2 (fast) 87.71(n)
    90(a)
      396434  NM_205450.1  NP_990781.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC532132 similar to troponin C2, fast 82.57(n)    BC041530.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tnnc2 troponin C, fast skeletal 80.02(n)   58082  BC064284.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TpnC41C6
    TpnC47D6
    (see all 9)
    Troponin C at 47D
    (see all 9)
    36(a)
    34(a)
    (see all 9)
    possible ortholog
    possible ortholog
    (see all 9)
    2R(952742-957715)
    2R(7161540-7162796)
    worm
    (Caenorhabditis elegans)
    Secernentea tnc-26
    cal-86
    (see all 4)
    Protein F12A10.5
    (see all 4)
    38(a)
    35(a)
    (see all 4)
    possible ortholog
    many ↔ many
    (see all 4)
    II(10466852-10468344)
    II(5480591-5482043)


    ENSEMBL Gene Tree for TNNC2 (if available)
    TreeFam Gene Tree for TNNC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNNC2 gene
    CALML32  CABP52  CABP12  TNNC12  CALM32  CABP42  CABP22  CALM12  
    CALML62  CALML52  CABP72  CALML42  CALN12  CALM22  
    18/35 SIMAP similar genes for TNNC2 using alignment to 3 protein entries:     TNNC2_HUMAN (see all proteins) (see all similar genes):
    TNNC1    CALM2    CALM1    CALML3    CALM3    CETN2
    CETN1    CALML6    OCM    OCM2    CALML5    MYL1
    MYL6    CETN3    MYL3    PPP3R1    MYL6B    CALN1

    TNNC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/154 SNPs in TNNC2 are shown (see all 154)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs798606461,2
    C,F--44451360(+) GATGGG/ACACCT 1 -- ds50011Minor allele frequency- A:0.04EA 120
    rs60176971,2
    C,H--44451552(+) TCACCC/TTGACT 1 -- ds50015Minor allele frequency- T:0.00NS EA NA 422
    rs60739231,2
    C,H--44451628(+) CGCCAG/TCTGTC 1 -- ds50014Minor allele frequency- T:0.00NS EA 414
    rs1122613841,2
    F--44451640(+) GGAGCC/AGGCTG 1 -- ds50012Minor allele frequency- A:0.10CSA WA 120
    rs784535781,2
    C,F--44451761(+) CCCAAG/AGGTGC 1 -- ds50012Minor allele frequency- A:0.10WA 120
    rs1854726581,2
    --44451849(+) GGCCAC/TGAGTT 1 -- ds50010--------
    rs88601,2
    C,F,H--44451901(-) GCGCGG/ACCCCT 1 -- ut31 ese325Minor allele frequency- A:0.35MN NS EA NA WA CSA 2531
    rs352801171,2
    C,F,H--44451918(+) GGTGGG/AGACCC 1 -- ut317Minor allele frequency- A:0.03NS NA WA 1072
    rs1881251711,2
    C--44451943(+) TCCCAC/TACCCT 1 -- ut310--------
    rs1121411901,2
    C--44452020(+) AACTCG/TGAGGG 1 -- spa10--------

    HapMap Linkage Disequilibrium report for TNNC2 (44451853 - 44462384 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TNNC2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833990CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 191039    OMIM disorders: --

    2 diseases for TNNC2:    About MalaCards
    distal arthrogryposis    clubfoot

    2 diseases from the University of Copenhagen DISEASES database for TNNC2:
    Distal arthrogryposis     Clubfoot

    TNNC2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TNNC2
    Human Genome Epidemiology (HuGE) Navigator: TNNC2 (3 documents)

    Export disorders for TNNC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNNC2 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with TNNC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene. (PubMed id 2373703)1, 2, 3, 9 Gahlmann R. and Kedes L. (1990)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    5. Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts. (PubMed id 3166492)1, 2 Gahlmann R.... Kedes L. (1988)
    6. Human skeletal muscle proteins. The primary structure of troponin C. (PubMed id 978749)1, 2 Romero-Herrera A.E.... Lehmann H. (1976)
    7. Binding properties of the calcium-activated F2 isofor m of Lethocerus troponin C. (PubMed id 21250664)7 Martin S.R....Pastore A. (2011)
    8. Calcium binding kinetics of troponin C strongly modul ate cooperative activation and tension kinetics in cardiac muscle. (PubMed id 21035455)7 Kreutziger K.L....Regnier M. (2011)
    9. A dilated cardiomyopathy troponin C mutation lowers c ontractile force by reducing strong myosin-actin binding. (PubMed id 20371872)7 Dweck D....Potter J.D. (2010)
    10. A structural and functional perspective into the mech anism of Ca2+-sensitizers that target the cardiac troponin complex. (PubMed id 20801130)7 Robertson I.M....Sykes B.D. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7125 HGNC: 11944 AceView: TNNC2 Ensembl:ENSG00000101470 euGenes: HUgn7125
    ECgene: TNNC2 Kegg: 7125 H-InvDB: TNNC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNNC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNNC2 gene:
    Search GeneIP for patents involving TNNC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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