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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNNC2 Gene

protein-coding   GIFtS: 56
GCID: GC20M044451

troponin C type 2 (fast)

(Previous names: troponin C2, fast )
 Explore 3 diseases affiliated with
TNNC2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TNNC2    

Aliases
for TNNC2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Troponin C Type 2 (Fast)1 2
Troponin C2, Fast1 2
Troponin C, Skeletal Muscle2

External Ids:    HGNC: 119441   Entrez Gene: 71252   Ensembl: ENSG000001014707   OMIM: 1910395   UniProtKB: P025853   

Export aliases for TNNC2 gene to outside databases

Previous GC identifers: GC20M044180 GC20M044140 GC20M045090 GC20M045137 GC20M043885 GC20M041193


Summaries
for TNNC2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TNNC2:
Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The
Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds
calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this
gene is the Tn-C subunit. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNNC2_HUMAN, P02585
Function: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components:
Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The
binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments

Gene Wiki entry for TNNC2


Genomic Views
for TNNC2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNNC2 gene promoter:
         Egr-3   Max1   AhR   MyoD   Lmo2   Arnt   Egr-2   HFH-1   Msx-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNNC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNNC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNNC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.11   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12-q13.11

TNNC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNNC2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M044451:  view genomic region     (about GC identifiers)

Start:
 44,451,853 bp from pter      End:
 44,462,384 bp from pter
Size:
 10,532 bases      Orientation:
 minus strand

Proteins
for TNNC2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TNNC2_HUMAN, P02585 (See protein sequence)
Recommended Name: Troponin C, skeletal muscle  
Size: 160 amino acids; 18122 Da
Miscellaneous: Skeletal muscle troponin C binds four calcium ions

Explore the universe of human proteins at neXtProt for TNNC2: NX_P02585

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P02585

    • TNNC2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003270.1  
    ENSEMBL proteins: 
     ENSP00000361636   ENSP00000361638  
    Reactome Protein details: P02585
    Human Recombinant Protein Products: 
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    Uscn Proteins for TNNC2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005861troponin complex IDA17194691


    TNNC2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TNNC2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TNNC2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR018247 EF_Hand_1_Ca_BS
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd

    Graphical View of Domain Structure for InterPro Entry P02585

    ProtoNet protein and cluster: P02585

    UniProtKB/Swiss-Prot: TNNC2_HUMAN, P02585
    Similarity: Belongs to the troponin C family
    Similarity: Contains 4 EF-hand domains


    Function
    for TNNC2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TNNC2_HUMAN, P02585
    Function: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components:
    Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The
    binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments

         Genatlas biochemistry entry for TNNC2:
    troponin C2,calcium binding subunit,component of the troponin complex forming the calcium-sensitive molecular switch
    that regulates striated muscle contraction in response to modifications in intracellular concentration,fast twitch
    skeletal muscle

    miRNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779contributes to actin binding IDA17194691
    GO:0005509calcium ion binding IEA--


    TNNC2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for TNNC2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Striated Muscle Contraction
    		Striated Muscle Contraction1.00
    		Muscle contraction0.65
    		Striated Muscle Contraction0.87
    2Calcium signaling pathway
    		Calcium signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for TNNC2 
        Striated Muscle Contraction

    2        Reactome Pathways for TNNC2
        Muscle contraction
    Striated Muscle Contraction


    1         Kegg Pathway  (Kegg details for TNNC2):
        Calcium signaling pathway


    TNNC2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TNNC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for TNNC2 (P025853 ENSP000003616364) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNNI2P487883, ENSP000002528984I2D: score=1 STRING: ENSP00000252898
    ACTN2ENSP000003555374STRING: ENSP00000355537
    DESENSP000003630714STRING: ENSP00000363071
    MYBPC1ENSP000003548494STRING: ENSP00000354849
    MYBPC2ENSP000003503324STRING: ENSP00000350332
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003009skeletal muscle contraction IDA17194691
    GO:0006937regulation of muscle contraction TAS2373703
    GO:0030049muscle filament sliding TAS--


    TNNC2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TNNC2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNNC2

    1 HMDB Compound for TNNC2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for TNNC2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Calcium-- --targetagonist20371872 20801130 21250664 21035455
    FelodipineDl-Felodipine (see all 4)72509-76-3targetother3178884 10592235
    Octylphenoxy polyethoxyethanolalkylphenol-hydroxypolyoxyetheylene (see all 2)9036-19-5target--10592235

    Search CenterWatch for drugs/clinical trials and news about TNNC2 

    Transcripts
    for TNNC2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TNNC2 gene: 
    NM_003279.2  

    Unigene Cluster for TNNC2:

    Troponin C type 2 (fast)
    Hs.182421  [show with all ESTs]
    Unigene Representative Sequence: BF574800
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372555(uc002xpr.3) ENST00000372557

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    Additional cDNA sequence: 

    AK291323.1 AK300665.1 BC005323.1 CR541864.1 CR541884.1 M22307.1 X07898.1 

    14 DOTS entries:

    DT.101985358  DT.120817722  DT.119490  DT.120817136  DT.120817198  DT.95277780  DT.100023184  DT.120817210 
    DT.120817835  DT.120817685  DT.120817575  DT.95280722  DT.102835624  DT.95081953 

    24/326 AceView cDNA sequences (see all 326):

    F29188 F34343 AI080746 F30132 F31168 F30072 F29981 F26105 
    F31343 F36228 F29196 F26680 AA442911 F21518 F29162 F19531 
    F24962 F26530 AA176669 F30949 F26352 F30437 F27471 F29298 

    GeneLoc Exon Structure


    Expression
    for TNNC2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNNC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGGTGCGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TNNC2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/19 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 19) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb Dorsal MusclesMultinuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleAnterior Neck MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleCervical Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Vertebrae Column MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MusclePelvic MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MusclePosterior Neck MusclesMultinuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TNNC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNNC2

    SOURCE GeneReport for Unigene cluster: Hs.182421
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    In Situ
    Assay Products:     
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    Orthologs
    for TNNC2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TNNC2 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TNNC21 troponin C type 2 (fast) 87.71(n)
    90(a)    		   396434  NM_205450.1  NP_990781.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC532132 similar to troponin C2, fast 82.57(n)    BC041530.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii tnnc2 troponin C, fast skeletal 80.02(n)   58082  BC064284.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 38(a)
    		 possible ortholog
    		 Group13.2(92169-97586)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATCAL46
    		 calmodulin-like protein 12
    		 19(a)
    		 1 → many
    		 2(17137829-17139612)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 OsCML6 - Calmodulin-related calcium sensor protein...
    		 39(a)
    		 1 → many
    		 11(21707347-21708627)


    ENSEMBL Gene Tree for TNNC2 (if available)
    TreeFam Gene Tree for TNNC2 (if available) 

    Paralogs
    for TNNC2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNNC2 gene
    CALML32  CABP52  CABP12  TNNC12  CALM32  CABP42  CABP22  CALM12  
    CALML62  CALML52  CALML42  CABP72  CALN12  CALM22  
    18/35 SIMAP similar genes for TNNC2 using alignment to 3 protein entries:     TNNC2_HUMAN (see all proteins) (see all similar genes):
    TNNC1    CALM2    CALM1    CALM3    CALML3    CETN2
    CETN1    CALML6    OCM    OCM2    CALML5    MYL1
    MYL6    CETN3    MYL3    PPP3R1    MYL6B    CABP2

    TNNC2 for paralogs           About GeneDecksing



    Genomic Variants
    for TNNC2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/116 NCBI SNPs in TNNC2 are shown (see all 116)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs798606461,2
    		F,--44451360(+) GATGGG/ACACCT 1 -- ds50011Minor allele frequency- A:0.04EA 120
    rs60176971,2
    		C,H--44451552(+) TCACCC/TTGACT 1 -- ds50015Minor allele frequency- T:0.00NS EA NA 422
    rs60739231,2
    		C,H--44451628(+) CGCCAG/TCTGTC 1 -- ds50014Minor allele frequency- T:0.00NS EA 414
    rs1122613841,2
    		--44451640(+) GGAGCC/AGGCTG 1 -- ds50012Minor allele frequency- A:0.10CSA WA 120
    rs784535781,2
    		C,--44451761(+) CCCAAG/AGGTGC 1 -- ds50012Minor allele frequency- A:0.10WA 120
    rs1854726581,2
    		--44451849(+) GGCCAC/TGAGTT 1 -- ds50010--------
    rs88601,2
    		C,F,H,--44451901(-) GCGCGG/ACCCCT 1 -- ut31 ese325Minor allele frequency- A:0.35MN NS EA NA WA CSA 2531
    rs352801171,2
    		C,F,H,--44451918(+) GGTGGG/AGACCC 1 -- ut317Minor allele frequency- A:0.03NS NA WA 1072
    rs1881251711,2
    		C,--44451943(+) TCCCAC/TACCCT 1 -- ut310--------
    rs1812854161,2
    		--44452080(+) CCAGGC/GCTCCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TNNC2 (44451853 - 44462384 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TNNC2: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for TNNC2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TNNC2 for disorders           About GeneDecksing

    OMIM gene information: 191039    OMIM disorders: --

    3 diseases for TNNC2:    About MalaCards
    distal arthrogryposis    arthrogryposis    immunodeficiency

    2 diseases from the University of Copenhagen DISEASES database for TNNC2:
    Distal arthrogryposis     Clubfoot
    Human Genome Epidemiology (HuGE) Navigator: TNNC2 (3 documents)

    Export disorders for TNNC2 gene to outside databases

    Publications
    for TNNC2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNNC2 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with TNNC2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene. (PubMed id 2373703)1, 2, 3, 9 Gahlmann R. and Kedes L. (1990)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    4. Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts. (PubMed id 3166492)1, 2 Gahlmann R.... Kedes L. (1988)
    5. Human skeletal muscle proteins. The primary structure of troponin C. (PubMed id 978749)1, 2 Romero-Herrera A.E.... Lehmann H. (1976)
    6. Binding properties of the calcium-activated F2 isofor m of Lethocerus troponin C. (PubMed id 21250664)7 Martin S.R....Pastore A. (2011)
    7. Calcium binding kinetics of troponin C strongly modul ate cooperative activation and tension kinetics in cardiac muscle. (PubMed id 21035455)7 Kreutziger K.L....Regnier M. (2011)
    8. A dilated cardiomyopathy troponin C mutation lowers c ontractile force by reducing strong myosin-actin binding. (PubMed id 20371872)7 Dweck D....Potter J.D. (2010)
    9. A structural and functional perspective into the mech anism of Ca2+-sensitizers that target the cardiac troponin complex. (PubMed id 20801130)7 Robertson I.M....Sykes B.D. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)

    External Searches for TNNC2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing TNNC2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7125 HGNC: 11944 AceView: TNNC2 Ensembl:ENSG00000101470 euGenes: HUgn7125
    ECgene: TNNC2 Kegg: 7125 H-InvDB: TNNC2

    Other Databases showing TNNC2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TNNC2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNNC2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TNNC2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TNNC2 gene:
    Search GeneIP for patents involving TNNC2

    GeneCards and IP:
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