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Aliases for TNNC2 Gene

Aliases for TNNC2 Gene

  • Troponin C Type 2 (Fast) 2 3
  • Troponin C2, Fast 2

External Ids for TNNC2 Gene

Previous GeneCards Identifiers for TNNC2 Gene

  • GC20M044180
  • GC20M044140
  • GC20M045090
  • GC20M045137
  • GC20M043885
  • GC20M044451
  • GC20M041193

Summaries for TNNC2 Gene

Entrez Gene Summary for TNNC2 Gene

  • Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNNC2 Gene

TNNC2 (Troponin C Type 2 (Fast)) is a Protein Coding gene. Among its related pathways are Calcium signaling pathway and Striated Muscle Contraction. GO annotations related to this gene include calcium ion binding and actin binding. An important paralog of this gene is CABP2.

UniProtKB/Swiss-Prot for TNNC2 Gene

  • Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments

Gene Wiki entry for TNNC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNNC2 Gene

Genomics for TNNC2 Gene

Regulatory Elements for TNNC2 Gene

Genomic Location for TNNC2 Gene

Start:
45,823,214 bp from pter
End:
45,833,745 bp from pter
Size:
10,532 bases
Orientation:
Minus strand

Genomic View for TNNC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNNC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNNC2 Gene

Proteins for TNNC2 Gene

  • Protein details for TNNC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02585-TNNC2_HUMAN
    Recommended name:
    Troponin C, skeletal muscle
    Protein Accession:
    P02585
    Secondary Accessions:
    • Q6FH92

    Protein attributes for TNNC2 Gene

    Size:
    160 amino acids
    Molecular mass:
    18122 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Skeletal muscle troponin C binds four calcium ions

neXtProt entry for TNNC2 Gene

Proteomics data for TNNC2 Gene at MOPED

Post-translational modifications for TNNC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNNC2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TNNC2 Gene

Domains for TNNC2 Gene

Gene Families for TNNC2 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for TNNC2 Gene

Suggested Antigen Peptide Sequences for TNNC2 Gene

Graphical View of Domain Structure for InterPro Entry

P02585

UniProtKB/Swiss-Prot:

TNNC2_HUMAN :
  • P02585
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the troponin C family.
genes like me logo Genes that share domains with TNNC2: view

Function for TNNC2 Gene

Molecular function for TNNC2 Gene

GENATLAS Biochemistry: troponin C2,calcium binding subunit,component of the troponin complex forming the calcium-sensitive molecular switch that regulates striated muscle contraction in response to modifications in intracellular concentration,fast twitch skeletal muscle
UniProtKB/Swiss-Prot Function: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments

Gene Ontology (GO) - Molecular Function for TNNC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 contributes_to actin binding IDA 17194691
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TNNC2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TNNC2 Gene

Localization for TNNC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNNC2 Gene COMPARTMENTS Subcellular localization image for TNNC2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 1

Gene Ontology (GO) - Cellular Components for TNNC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix --
GO:0005829 cytosol TAS --
GO:0005861 troponin complex IDA 17194691
genes like me logo Genes that share ontologies with TNNC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TNNC2 Gene

Pathways for TNNC2 Gene

genes like me logo Genes that share pathways with TNNC2: view

Pathways by source for TNNC2 Gene

1 BioSystems pathway for TNNC2 Gene
2 Reactome pathways for TNNC2 Gene
1 KEGG pathway for TNNC2 Gene

Gene Ontology (GO) - Biological Process for TNNC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003009 skeletal muscle contraction IDA 17194691
GO:0006937 regulation of muscle contraction TAS 2373703
GO:0007165 signal transduction --
GO:0030049 muscle filament sliding TAS --
genes like me logo Genes that share ontologies with TNNC2: view

Compounds for TNNC2 Gene

(1) HMDB Compounds for TNNC2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(3) Drugbank Compounds for TNNC2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Calcium
target agonist
Felodipine
  • Dl-Felodipine
72509-76-3 target other
Octylphenoxy polyethoxyethanol
  • alkylphenol-hydroxypolyoxyetheylene
9036-19-5 target
genes like me logo Genes that share compounds with TNNC2: view

Transcripts for TNNC2 Gene

mRNA/cDNA for TNNC2 Gene

(326) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNNC2 Gene

Troponin C type 2 (fast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNNC2 Gene

No ASD Table

Relevant External Links for TNNC2 Gene

GeneLoc Exon Structure for
TNNC2
ECgene alternative splicing isoforms for
TNNC2

Expression for TNNC2 Gene

mRNA expression in normal human tissues for TNNC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNNC2 Gene

This gene is overexpressed in Muscle - Skeletal (51.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNNC2 Gene

SOURCE GeneReport for Unigene cluster for TNNC2 Gene Hs.182421

genes like me logo Genes that share expressions with TNNC2: view

No data available for mRNA Expression by UniProt/SwissProt for TNNC2 Gene

Orthologs for TNNC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TNNC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNNC2 35
  • 100 (n)
  • 100 (a)
TNNC2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNNC2 35
  • 93.5 (n)
  • 98.11 (a)
TNNC2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNNC2 35
  • 94.17 (n)
  • 99.37 (a)
TNNC2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnnc2 35
  • 90.21 (n)
  • 98.75 (a)
Tnnc2 16
Tnnc2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNNC2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnnc2 35
  • 91.46 (n)
  • 99.37 (a)
chicken
(Gallus gallus)
Aves TNNC2 35
  • 87.71 (n)
  • 90 (a)
TNNC2 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 41 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC53213 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75744 35
tnnc2 35
  • 81.34 (n)
  • 90.57 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9508 35
zebrafish
(Danio rerio)
Actinopterygii tnnc 35
tnnc2 35
  • 76.67 (n)
  • 78.75 (a)
tnnc2 36
  • 79 (a)
OneToMany
TNNC2 (2 of 2) 36
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta And 36
  • 47 (a)
ManyToMany
CG11165 36
  • 35 (a)
ManyToMany
CG31958 36
  • 32 (a)
ManyToMany
CG31960 36
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cal-1 36
  • 38 (a)
ManyToMany
cal-2 36
  • 40 (a)
ManyToMany
cal-3 36
  • 29 (a)
ManyToMany
cal-4 36
  • 25 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMD1 36
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToOne
Species with no ortholog for TNNC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNNC2 Gene

ENSEMBL:
Gene Tree for TNNC2 (if available)
TreeFam:
Gene Tree for TNNC2 (if available)

Paralogs for TNNC2 Gene

genes like me logo Genes that share paralogs with TNNC2: view

Variants for TNNC2 Gene

Sequence variations from dbSNP and Humsavar for TNNC2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs4629 -- 45,824,058(-) GTGAC(G/T)GACGA reference, synonymous-codon
rs8860 -- 45,823,262(-) GCGCG(A/G)CCCCT utr-variant-3-prime
rs370237 -- 45,825,016(+) tctcg(C/T)tctgt intron-variant
rs378710 -- 45,823,613(+) GCCCC(C/G)GGAGC intron-variant
rs558554 -- 45,825,782(+) cgccc(A/G)gctaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNNC2 Gene

Variant ID Type Subtype PubMed ID
nsv833990 CNV Loss 17160897

Relevant External Links for TNNC2 Gene

HapMap Linkage Disequilibrium report
TNNC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNNC2 Gene

Disorders for TNNC2 Gene

(2) University of Copenhagen DISEASES for TNNC2 Gene

Relevant External Links for TNNC2

Genetic Association Database (GAD)
TNNC2
Human Genome Epidemiology (HuGE) Navigator
TNNC2
genes like me logo Genes that share disorders with TNNC2: view

No data available for UniProtKB/Swiss-Prot for TNNC2 Gene

Publications for TNNC2 Gene

  1. Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene. (PMID: 2373703) Gahlmann R. … Kedes L. (J. Biol. Chem. 1990) 2 3 4 23
  2. Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts. (PMID: 3166492) Gahlmann R. … Kedes L. (J. Mol. Biol. 1988) 3 4
  3. Human skeletal muscle proteins. The primary structure of troponin C. (PMID: 978749) Romero-Herrera A.E. … Lehmann H. (J. Mol. Evol. 1976) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TNNC2 Gene

Sources for TNNC2 Gene

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