External Ids for TNN Gene
Previous GeneCards Identifiers for TNN Gene
GeneCards Summary for TNN Gene
TNN (Tenascin N) is a Protein Coding gene. Diseases associated with TNN include Adhesive Otitis Media and Chronic Purulent Otitis Media. Among its related pathways are ECM proteoglycans and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and integrin binding. An important paralog of this gene is TNC.
UniProtKB/Swiss-Prot for TNN Gene
Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022).