TNN Gene
protein-coding GIFtS: 51
GCID: GC01P175036
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tenascin N
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Aliases
for TNN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tenascin N1 2 | | TN-N2 3 | | TN-W2 | | Tenascin-N1 |
Export aliases for TNN gene to outside databasesPrevious GC identifers: GC01P171627 GC01P172286 GC01P172276 GC01P171768 GC01P173303 GC01P146264 |
Summaries
for TNN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TENN_HUMAN, Q9UQP3Function: Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity)
|
Genomic Views
for TNN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TNN gene promoter:
CREB RP58 AML1a Pbx1a FOXJ2 (long isoform) deltaCREB FOXJ2 E4BP4
Other transcription factors
Search SABiosciences Chromatin IP Primers for TNN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q23-q24 Ensembl cytogenetic band: 1q25.1 HGNC cytogenetic band: 1q23-q24TNN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P175036: view genomic region
(about GC identifiers)
Start:
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175,036,994 bp from pter |
End:
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175,117,202 bp from pter |
Size:
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80,209 bases |
Orientation:
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plus strand |
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Proteins
for TNN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TENN_HUMAN, Q9UQP3 (See
protein sequence)Recommended Name: Tenascin-N precursor Size: 1299 amino acids; 144034 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: B9EGP3 Q5R360Explore the universe of human proteins at neXtProt for TNN: NX_Q9UQP3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UQP3
TNN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071376.1
ENSEMBL proteins: ENSP00000239462
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TNN for ontologies About GeneDecksing
TNN Antibody Products:
Assay Products for TNN: |
Protein
Domains /
Families
for TNN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TNN for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9UQP3ProtoNet protein and cluster: Q9UQP3 1 Blocks protein family: IPB002181 Fibrinogen
UniProtKB/Swiss-Prot: TENN_HUMAN, Q9UQP3Similarity: Belongs to the tenascin familySimilarity: Contains 3 EGF-like domainsSimilarity: Contains 1 fibrinogen C-terminal domainSimilarity: Contains 9 fibronectin type-III domains |
Function
for TNN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TENN_HUMAN, Q9UQP3Function: Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNN (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNN |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TNN for ontologies About GeneDecksing
|
Pathways & Interactions
for TNN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Focal Adhesion | | | 2 | ECM-receptor interaction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for TNN
2 
Kegg Pathways (Kegg details for TNN):
TNN for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TNN
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/25 Interacting proteins for TNN (Q9UQP33 ENSP000002394624) via UniProtKB, MINT, STRING, and/or I2D (see all 25)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
TNN for ontologies About GeneDecksing
|
Drugs & Compounds
for TNN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TNN
Search CenterWatch for drugs/clinical trials and news about TNN / TENN
|
Transcripts
for TNN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TNN gene: NM_022093.1 Unigene Cluster for TNN: Tenascin N Hs.156369 [show with all ESTs]Unigene Representative Sequence: AK1270441 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000239462(uc010pmx.1 uc001gkl.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNN (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TNN (NM_001903) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNN | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNN |
Additional cDNA sequence: AK127044.1 AK127654.1 AL049689.1 BC136619.1 BC144305.1 1 DOTS entry: DT.40267896 13 AceView cDNA sequences: AL049689 BM677670 BF432086 BM723148 AI378673 AK127044 AI803573 BM712922 BX095893 AA558949 CF780884 AK127654 AI338459
GeneLoc Exon Structure
|
Expression
for TNN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TNN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCACCAGGC
About this image
See TNN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNN
SOURCE GeneReport for Unigene cluster: Hs.156369
SABiosciences Custom PCR Arrays for TNN
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNN
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNN | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNN |
Orthologs
for TNN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TNN gene from 3/12 species (see all 12) About this table
ENSEMBL Gene Tree for TNN (if available)
TreeFam Gene Tree for TNN (if available) |
Paralogs
for TNN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TNN gene
- TNR2 FIBCD12 FCN32 FCN12 FCN22 TNXB2 MFAP42 FN12
- TNC2 ANGPTL52
9 SIMAP similar genes for TNN using alignment to 1 protein entry: TENN_HUMAN:FCN2 FCN3 ANGPTL7 MFAP4 FCN1 FGL1
TNC variant protein TNR FN1
TNN for paralogs About GeneDecksing
|
Genomic Variants
for TNN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TNN (175036994 - 175117202 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TNN
3 CNVs: 97560 34736 65269 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNN |
|
Disorders
/ Diseases
for TNN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TNN for disorders About GeneDecksing
6  diseases for TNN: About MalaCardstrigeminal neuralgia familial colorectal cancer nevus colorectal cancer
periodontitis breast cancer
1 disease from the University of Copenhagen DISEASES database for TNN:Dysplastic nevus syndrome Human Genome Epidemiology (HuGE) Navigator: TNN (2 documents)
Export disorders for TNN gene to outside databases
|
Publications
for TNN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TNN gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with TNN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- Tenascin-N: characterization of a novel member of the tenascin family that mediates neurite repulsion from hippocampal explants. (PubMed id 12812753)1, 9 Neidhardt J....Schachner M. (2003)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Tenascin-W, a new marker of cancer stroma, is elevated in sera of colon and breast cancer patients. (PubMed id 18306355)1 Degen M....Seelentag W. (2008)
- Tenascin-W is a novel marker for activated tumor stroma in low-grade human breast cancer and influences cell behavior. (PubMed id 17909022)1 Degen M....Chiquet-Ehrismann R. (2007)
- Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro. (PubMed id 15592496)1 Scherberich A....Chiquet-Ehrismann R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The NH2 terminus of titin spans the Z-disc: its inter action with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity. (PubMed id 9817758)1 Gregorio C.C....Labeit S. (1998)
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External Searches for TNN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TNN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TNN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TNN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TNN gene:
Search GeneIP for patents involving TNN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TNN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TNN | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNN | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TNN | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | TNN Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNN |
|  |  |  | | | | Search ThermoFisher Antibodies for TNN |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNN |
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