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Aliases for TNN Gene

Aliases for TNN Gene

  • Tenascin N 2 3
  • TN-N 3 4
  • Tenascin-N 3
  • TNNC2 6
  • TN-W 3

External Ids for TNN Gene

Previous GeneCards Identifiers for TNN Gene

  • GC01P171627
  • GC01P172286
  • GC01P172276
  • GC01P171768
  • GC01P173303
  • GC01P175036
  • GC01P146264

Summaries for TNN Gene

GeneCards Summary for TNN Gene

TNN (Tenascin N) is a Protein Coding gene. Diseases associated with TNN include dysplastic nevus syndrome. Among its related pathways are PI3K-Akt signaling pathway and MicroRNAs in cancer. GO annotations related to this gene include identical protein binding and integrin binding. An important paralog of this gene is TNC.

UniProtKB/Swiss-Prot for TNN Gene

  • Involved in neurite outgrowth and cell migration in hippocampal explants.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNN Gene

Genomics for TNN Gene

Regulatory Elements for TNN Gene

Genomic Location for TNN Gene

Start:
175,067,858 bp from pter
End:
175,148,066 bp from pter
Size:
80,209 bases
Orientation:
Plus strand

Genomic View for TNN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNN Gene

Proteins for TNN Gene

  • Protein details for TNN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQP3-TENN_HUMAN
    Recommended name:
    Tenascin-N
    Protein Accession:
    Q9UQP3
    Secondary Accessions:
    • B9EGP3
    • Q5R360

    Protein attributes for TNN Gene

    Size:
    1299 amino acids
    Molecular mass:
    144034 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TNN Gene

Proteomics data for TNN Gene at MOPED

Post-translational modifications for TNN Gene

  • Glycosylation at Asn1149
  • Modification sites at PhosphoSitePlus

Other Protein References for TNN Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TNN Gene

Domains for TNN Gene

Gene Families for TNN Gene

HGNC:
  • FIBC :Fibrinogen C domain containing
  • FN3 :Fibronectin type III domain containing

Suggested Antigen Peptide Sequences for TNN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UQP3

UniProtKB/Swiss-Prot:

TENN_HUMAN :
  • Q9UQP3
Domain:
  • Contains 3 EGF-like domains.
  • Contains 1 fibrinogen C-terminal domain.
  • Contains 9 fibronectin type-III domains.
Family:
  • Belongs to the tenascin family.
genes like me logo Genes that share domains with TNN: view

Function for TNN Gene

Molecular function for TNN Gene

UniProtKB/Swiss-Prot Function: Involved in neurite outgrowth and cell migration in hippocampal explants.

Gene Ontology (GO) - Molecular Function for TNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005178 integrin binding IEA --
GO:0005515 protein binding --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with TNN: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TNN Gene

Localization for TNN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNN Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNN Gene COMPARTMENTS Subcellular localization image for TNN gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with TNN: view

Pathways for TNN Gene

genes like me logo Genes that share pathways with TNN: view

Gene Ontology (GO) - Biological Process for TNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion IEA --
GO:0007409 axonogenesis IEA --
GO:0016049 cell growth ISS --
GO:0016477 cell migration ISS --
genes like me logo Genes that share ontologies with TNN: view

Transcripts for TNN Gene

mRNA/cDNA for TNN Gene

Unigene Clusters for TNN Gene

Tenascin N:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNN Gene

No ASD Table

Relevant External Links for TNN Gene

GeneLoc Exon Structure for
TNN
ECgene alternative splicing isoforms for
TNN

Expression for TNN Gene

mRNA expression in normal human tissues for TNN Gene

mRNA differential expression in normal tissues according to GTEx for TNN Gene

This gene is overexpressed in Breast - Mammary Tissue (9.6), Skin - Not Sun Exposed (Suprapubic) (9.2), Adipose - Subcutaneous (6.5), and Adipose - Visceral (Omentum) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNN Gene

SOURCE GeneReport for Unigene cluster for TNN Gene Hs.156369

genes like me logo Genes that share expressions with TNN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TNN Gene

Orthologs for TNN Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNN 35
  • 98.87 (n)
  • 98.23 (a)
TNN 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNN 35
  • 87.76 (n)
  • 86.19 (a)
TNN 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNN 35
  • 87.51 (n)
  • 86.01 (a)
TNN 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnn 35
  • 78.85 (n)
  • 75.31 (a)
Tnn 16
Tnn 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNN 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNN 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnn 35
  • 79.01 (n)
  • 75.4 (a)
chicken
(Gallus gallus)
Aves TNN 35
  • 64.25 (n)
  • 57.54 (a)
TNN 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNN 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnn 35
  • 53.04 (n)
  • 46.35 (a)
zebrafish
(Danio rerio)
Actinopterygii tenw 35
tnw 36
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for TNN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNN Gene

ENSEMBL:
Gene Tree for TNN (if available)
TreeFam:
Gene Tree for TNN (if available)

Paralogs for TNN Gene

Paralogs for TNN Gene

Selected SIMAP similar genes for TNN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNN: view

Variants for TNN Gene

Sequence variations from dbSNP and Humsavar for TNN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs744008 -- 175,098,875(-) CAAGG(A/T)GAAGC intron-variant
rs744010 -- 175,124,235(+) TGAGC(G/T)CACCA intron-variant
rs763249 -- 175,093,056(-) aaaga(A/G)gaatg intron-variant
rs763250 -- 175,092,967(-) gtcac(A/C)cagga intron-variant
rs763251 -- 175,092,802(-) GCTTG(G/T)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNN Gene

Variant ID Type Subtype PubMed ID
nsv825487 CNV Gain 20364138
nsv3609 CNV Loss 18451855
nsv508648 CNV Loss 20534489
esv2719596 CNV Deletion 23290073
esv2719607 CNV Deletion 23290073
esv2566793 CNV Deletion 19546169
nsv498693 CNV Loss 21111241
dgv81e199 CNV Deletion 23128226
nsv3620 CNV Insertion 18451855
esv28085 CNV Gain 19812545
nsv821166 CNV Deletion 20802225
esv2719618 CNV Deletion 23290073
esv2159196 CNV Deletion 18987734
nsv160653 CNV Loss 16902084
nsv522101 CNV Loss 19592680

Relevant External Links for TNN Gene

HapMap Linkage Disequilibrium report
TNN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNN Gene

Disorders for TNN Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TNN Gene including...

Search for TNN Gene in MalaCards »

(1) University of Copenhagen DISEASES for TNN Gene

Relevant External Links for TNN

Genetic Association Database (GAD)
TNN
Human Genome Epidemiology (HuGE) Navigator
TNN
genes like me logo Genes that share disorders with TNN: view

No data available for UniProtKB/Swiss-Prot for TNN Gene

Publications for TNN Gene

  1. Tenascin-N: characterization of a novel member of the tenascin family that mediates neurite repulsion from hippocampal explants. (PMID: 12812753) Neidhardt J. … Schachner M. (Mol. Cell. Neurosci. 2003) 3 23
  2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Tenascin-W is a novel marker for activated tumor stroma in low-grade human breast cancer and influences cell behavior. (PMID: 17909022) Degen M. … Chiquet-Ehrismann R. (Cancer Res. 2007) 3
  5. Tenascin-W, a new marker of cancer stroma, is elevated in sera of colon and breast cancer patients. (PMID: 18306355) Degen M. … Seelentag W. (Int. J. Cancer 2008) 3

Products for TNN Gene

Sources for TNN Gene

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