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Aliases for TNN Gene

Aliases for TNN Gene

  • Tenascin N 2 3 5
  • Tenascin-W 3 4
  • TN-N 3 4
  • TN-W 3 4
  • Tenascin-N 3
  • TNW 4

External Ids for TNN Gene

Previous GeneCards Identifiers for TNN Gene

  • GC01P171627
  • GC01P172286
  • GC01P172276
  • GC01P171768
  • GC01P173303
  • GC01P175036
  • GC01P146264

Summaries for TNN Gene

GeneCards Summary for TNN Gene

TNN (Tenascin N) is a Protein Coding gene. Diseases associated with TNN include Adhesive Otitis Media and Chronic Purulent Otitis Media. Among its related pathways are ECM proteoglycans and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and integrin binding. An important paralog of this gene is TNC.

UniProtKB/Swiss-Prot for TNN Gene

  • Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022).

Additional gene information for TNN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNN Gene

Genomics for TNN Gene

GeneHancer (GH) Regulatory Elements for TNN Gene

Promoters and enhancers for TNN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I175067 Promoter 0.5 EPDnew 550.8 0.0 -43 0.1 TNN SDCCAG3P2
GH01I175071 Enhancer 1 Ensembl ENCODE 23 +4.9 4928 3.1 CTCF USF1 INSM2 MAX ZMYM3 CEBPG ZNF335 POLR2A ZNF366 SCRT2 TNN KIAA0040
GH01I174963 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.5 -100.1 -100110 9.2 HDGF PKNOX1 SMAD1 ARNT FEZF1 IRF4 YY1 ZNF766 JUNB ZNF592 RABGAP1L MRPS14 RNU6-307P CACYBP TNN KIAA0040 LOC101928696
GH01I175028 Enhancer 1.4 Ensembl ENCODE dbSUPER 5 -38.2 -38185 1.6 HDGF FOXA2 MLX ARNT ARID4B ZNF2 IRF4 ZNF766 ZNF207 ZNF143 RABGAP1L TNN MRPS14 GC01P175044
GH01I174448 Promoter 0.5 EPDnew 4.2 -619.8 -619783 0.1 GPR52 GC01M174448 TNN RABGAP1L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNN gene promoter:

Genomic Locations for TNN Gene

Genomic Locations for TNN Gene
chr1:175,067,858-175,148,066
(GRCh38/hg38)
Size:
80,209 bases
Orientation:
Plus strand
chr1:175,036,994-175,117,202
(GRCh37/hg19)

Genomic View for TNN Gene

Genes around TNN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNN Gene

Proteins for TNN Gene

  • Protein details for TNN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQP3-TENN_HUMAN
    Recommended name:
    Tenascin-N
    Protein Accession:
    Q9UQP3
    Secondary Accessions:
    • A0A0A6YY94
    • B9EGP3
    • Q5R360

    Protein attributes for TNN Gene

    Size:
    1299 amino acids
    Molecular mass:
    144034 Da
    Quaternary structure:
    • Homohexamer.

neXtProt entry for TNN Gene

Post-translational modifications for TNN Gene

Other Protein References for TNN Gene

No data available for DME Specific Peptides for TNN Gene

Domains & Families for TNN Gene

Gene Families for TNN Gene

Suggested Antigen Peptide Sequences for TNN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UQP3

UniProtKB/Swiss-Prot:

TENN_HUMAN :
  • Belongs to the tenascin family.
Family:
  • Belongs to the tenascin family.
genes like me logo Genes that share domains with TNN: view

Function for TNN Gene

Molecular function for TNN Gene

UniProtKB/Swiss-Prot Function:
Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022).

Phenotypes From GWAS Catalog for TNN Gene

Gene Ontology (GO) - Molecular Function for TNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005178 integrin binding IEA --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with TNN: view
genes like me logo Genes that share phenotypes with TNN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TNN Gene

Localization for TNN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNN Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNN gene
Compartment Confidence
extracellular 4
plasma membrane 2
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0009986 cell surface IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with TNN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNN Gene

Pathways & Interactions for TNN Gene

genes like me logo Genes that share pathways with TNN: view

Pathways by source for TNN Gene

Gene Ontology (GO) - Biological Process for TNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002076 osteoblast development ISS --
GO:0007160 cell-matrix adhesion IEA --
GO:0007409 axonogenesis IEA --
GO:0016049 cell growth IEA --
GO:0016477 cell migration IEA --
genes like me logo Genes that share ontologies with TNN: view

No data available for SIGNOR curated interactions for TNN Gene

Drugs & Compounds for TNN Gene

No Compound Related Data Available

Transcripts for TNN Gene

mRNA/cDNA for TNN Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNN Gene

Tenascin N:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNN Gene

No ASD Table

Relevant External Links for TNN Gene

GeneLoc Exon Structure for
TNN
ECgene alternative splicing isoforms for
TNN

Expression for TNN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNN Gene

mRNA differential expression in normal tissues according to GTEx for TNN Gene

This gene is overexpressed in Breast - Mammary Tissue (x9.6), Skin - Not Sun Exposed (Suprapubic) (x9.2), Adipose - Subcutaneous (x6.5), and Adipose - Visceral (Omentum) (x4.5).

Protein differential expression in normal tissues from HIPED for TNN Gene

This gene is overexpressed in Plasma (44.7), Testis (9.5), and Lung (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNN Gene



NURSA nuclear receptor signaling pathways regulating expression of TNN Gene:

TNN

SOURCE GeneReport for Unigene cluster for TNN Gene:

Hs.156369

mRNA Expression by UniProt/SwissProt for TNN Gene:

Q9UQP3-TENN_HUMAN
Tissue specificity: Not detected in normal adult mammary tissues or brain but expressed in most breast tumors and brain tumors, such as glioblastomas, astrocytomas and oligodendrogliomas, tested (PubMed:17909022, PubMed:19884327). In brain tumors, detected around the endothelial cell layer of the clood vessels (PubMed:19884327).

Evidence on tissue expression from TISSUES for TNN Gene

  • Bone marrow(4)
genes like me logo Genes that share expression patterns with TNN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNN Gene

Orthologs for TNN Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNN 33 34
  • 98.87 (n)
cow
(Bos Taurus)
Mammalia TNN 33 34
  • 87.76 (n)
dog
(Canis familiaris)
Mammalia TNN 33 34
  • 87.51 (n)
rat
(Rattus norvegicus)
Mammalia Tnn 33
  • 79.01 (n)
mouse
(Mus musculus)
Mammalia Tnn 33 16 34
  • 78.85 (n)
oppossum
(Monodelphis domestica)
Mammalia TNN 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNN 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNN 33 34
  • 64.25 (n)
lizard
(Anolis carolinensis)
Reptilia TNN 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnn 33
  • 53.04 (n)
zebrafish
(Danio rerio)
Actinopterygii tnw 34
  • 48 (a)
OneToOne
tenw 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
OneToMany
Species where no ortholog for TNN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNN Gene

ENSEMBL:
Gene Tree for TNN (if available)
TreeFam:
Gene Tree for TNN (if available)

Paralogs for TNN Gene

Paralogs for TNN Gene

(8) SIMAP similar genes for TNN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNN: view

Variants for TNN Gene

Sequence variations from dbSNP and Humsavar for TNN Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000099064 -- 175,132,974(+) C/T intron_variant
rs1000108505 -- 175,095,837(+) G/A intron_variant
rs1000136101 -- 175,116,346(+) C/G intron_variant
rs1000186204 -- 175,146,714(+) T/C intron_variant
rs1000200585 -- 175,110,898(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNN Gene

Variant ID Type Subtype PubMed ID
dgv62e214 CNV gain 21293372
dgv81e199 CNV deletion 23128226
esv2159196 CNV deletion 18987734
esv2566793 CNV deletion 19546169
esv2719596 CNV deletion 23290073
esv2719607 CNV deletion 23290073
esv2719618 CNV deletion 23290073
esv28085 CNV gain 19812545
esv3587975 CNV loss 21293372
nsv1011472 CNV loss 25217958
nsv1113194 CNV deletion 24896259
nsv160653 CNV deletion 16902084
nsv3609 CNV deletion 18451855
nsv3620 CNV insertion 18451855
nsv498693 CNV loss 21111241
nsv508648 CNV deletion 20534489
nsv522101 CNV loss 19592680
nsv821166 CNV deletion 20802225
nsv825487 CNV gain 20364138

Variation tolerance for TNN Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.53; 97.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNN Gene

Human Gene Mutation Database (HGMD)
TNN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNN Gene

Disorders for TNN Gene

MalaCards: The human disease database

(2) MalaCards diseases for TNN Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
adhesive otitis media
  • chronic adhesive otitis media
chronic purulent otitis media
  • chronic suppurative otitis media
- elite association - COSMIC cancer census association via MalaCards
Search TNN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TNN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNN Gene

Publications for TNN Gene

  1. Tenascin-W is a novel marker for activated tumor stroma in low-grade human breast cancer and influences cell behavior. (PMID: 17909022) Degen M … Chiquet-Ehrismann R (Cancer research 2007) 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 58
  4. Tenascin-N: characterization of a novel member of the tenascin family that mediates neurite repulsion from hippocampal explants. (PMID: 12812753) Neidhardt J … Schachner M (Molecular and cellular neurosciences 2003) 3 22 58
  5. Targeted next-generation sequencing assay for detection of mutations in primary myopathies. (PMID: 26627873) Evilä A … Hackman P (Neuromuscular disorders : NMD 2016) 3 58

Products for TNN Gene

Sources for TNN Gene

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