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Aliases for TNN Gene

Aliases for TNN Gene

  • Tenascin N 2 3
  • TN-N 3 4
  • TN-W 3

External Ids for TNN Gene

Previous GeneCards Identifiers for TNN Gene

  • GC01P171627
  • GC01P172286
  • GC01P172276
  • GC01P171768
  • GC01P173303
  • GC01P175036
  • GC01P146264

Summaries for TNN Gene

GeneCards Summary for TNN Gene

TNN (Tenascin N) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and MicroRNAs in cancer. GO annotations related to this gene include identical protein binding and integrin binding. An important paralog of this gene is TNC.

UniProtKB/Swiss-Prot for TNN Gene

  • Involved in neurite outgrowth and cell migration in hippocampal explants.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNN Gene

Genomics for TNN Gene

Regulatory Elements for TNN Gene

Genomic Location for TNN Gene

175,067,858 bp from pter
175,148,066 bp from pter
80,209 bases
Plus strand

Genomic View for TNN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNN Gene

Proteins for TNN Gene

  • Protein details for TNN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B9EGP3
    • Q5R360

    Protein attributes for TNN Gene

    1299 amino acids
    Molecular mass:
    144034 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TNN Gene

Proteomics data for TNN Gene at MOPED

Post-translational modifications for TNN Gene

  • Glycosylation at Asn 1149
  • Modification sites at PhosphoSitePlus

Other Protein References for TNN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNN Gene

Domains & Families for TNN Gene

Suggested Antigen Peptide Sequences for TNN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 EGF-like domains.
  • Belongs to the tenascin family.
  • Contains 3 EGF-like domains.
  • Contains 1 fibrinogen C-terminal domain.
  • Contains 9 fibronectin type-III domains.
  • Belongs to the tenascin family.
genes like me logo Genes that share domains with TNN: view

Function for TNN Gene

Molecular function for TNN Gene

UniProtKB/Swiss-Prot Function:
Involved in neurite outgrowth and cell migration in hippocampal explants.

Gene Ontology (GO) - Molecular Function for TNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005178 integrin binding IEA --
GO:0005515 protein binding --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with TNN: view

Phenotypes for TNN Gene

GenomeRNAi human phenotypes for TNN:
genes like me logo Genes that share phenotypes with TNN: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TNN Gene

Localization for TNN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNN Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for TNN Gene COMPARTMENTS Subcellular localization image for TNN gene
Compartment Confidence
extracellular 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with TNN: view

Pathways & Interactions for TNN Gene

genes like me logo Genes that share pathways with TNN: view

Pathways by source for TNN Gene

1 BioSystems pathway for TNN Gene
2 Reactome pathways for TNN Gene

Gene Ontology (GO) - Biological Process for TNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion IEA --
GO:0007409 axonogenesis IEA --
GO:0016049 cell growth ISS --
GO:0016477 cell migration ISS --
genes like me logo Genes that share ontologies with TNN: view

No data available for SIGNOR curated interactions for TNN Gene

Drugs & Compounds for TNN Gene

No Compound Related Data Available

Transcripts for TNN Gene

mRNA/cDNA for TNN Gene

Unigene Clusters for TNN Gene

Tenascin N:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNN Gene

No ASD Table

Relevant External Links for TNN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNN Gene

mRNA expression in normal human tissues for TNN Gene

mRNA differential expression in normal tissues according to GTEx for TNN Gene

This gene is overexpressed in Breast - Mammary Tissue (x9.6), Skin - Not Sun Exposed (Suprapubic) (x9.2), Adipose - Subcutaneous (x6.5), and Adipose - Visceral (Omentum) (x4.5).

Protein differential expression in normal tissues from HIPED for TNN Gene

This gene is overexpressed in Plasma (44.7), Testis (9.5), and Lung (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNN Gene

SOURCE GeneReport for Unigene cluster for TNN Gene Hs.156369

genes like me logo Genes that share expression patterns with TNN: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TNN Gene

Orthologs for TNN Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNN 35
  • 87.76 (n)
  • 86.19 (a)
TNN 36
  • 72 (a)
(Canis familiaris)
Mammalia TNN 35
  • 87.51 (n)
  • 86.01 (a)
TNN 36
  • 73 (a)
(Mus musculus)
Mammalia Tnn 35
  • 78.85 (n)
  • 75.31 (a)
Tnn 16
Tnn 36
  • 67 (a)
(Pan troglodytes)
Mammalia TNN 35
  • 98.87 (n)
  • 98.23 (a)
TNN 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Tnn 35
  • 79.01 (n)
  • 75.4 (a)
(Monodelphis domestica)
Mammalia TNN 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia TNN 36
  • 68 (a)
(Gallus gallus)
Aves TNN 35
  • 64.25 (n)
  • 57.54 (a)
TNN 36
  • 60 (a)
(Anolis carolinensis)
Reptilia TNN 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tnn 35
  • 53.04 (n)
  • 46.35 (a)
(Danio rerio)
Actinopterygii tenw 35
tnw 36
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for TNN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNN Gene

Gene Tree for TNN (if available)
Gene Tree for TNN (if available)

Paralogs for TNN Gene

Paralogs for TNN Gene

(8) SIMAP similar genes for TNN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNN: view

Variants for TNN Gene

Sequence variations from dbSNP and Humsavar for TNN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs744008 -- 175,098,875(-) CAAGG(A/T)GAAGC intron-variant
rs744010 -- 175,124,235(+) TGAGC(G/T)CACCA intron-variant
rs763249 -- 175,093,056(-) aaaga(A/G)gaatg intron-variant
rs763250 -- 175,092,967(-) gtcac(A/C)cagga intron-variant
rs763251 -- 175,092,802(-) GCTTG(G/T)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNN Gene

Variant ID Type Subtype PubMed ID
nsv825487 CNV Gain 20364138
nsv3609 CNV Loss 18451855
nsv508648 CNV Loss 20534489
esv2719596 CNV Deletion 23290073
esv2719607 CNV Deletion 23290073
esv2566793 CNV Deletion 19546169
nsv498693 CNV Loss 21111241
dgv81e199 CNV Deletion 23128226
nsv3620 CNV Insertion 18451855
esv28085 CNV Gain 19812545
nsv821166 CNV Deletion 20802225
esv2719618 CNV Deletion 23290073
esv2159196 CNV Deletion 18987734
nsv160653 CNV Loss 16902084
nsv522101 CNV Loss 19592680

Variation tolerance for TNN Gene

Residual Variation Intolerance Score: 92.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.53; 97.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNN Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNN Gene

Disorders for TNN Gene

Relevant External Links for TNN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TNN: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNN Gene

Publications for TNN Gene

  1. Transcriptome database KK-Periome for periodontal ligament development: expression profiles of the extracellular matrix genes. (PMID: 17928168) Nishida E. … Saito M. (Gene 2007) 23 67
  2. Tenascin-N: characterization of a novel member of the tenascin family that mediates neurite repulsion from hippocampal explants. (PMID: 12812753) Neidhardt J. … Schachner M. (Mol. Cell. Neurosci. 2003) 23 67
  3. The tenascin family of ECM glycoproteins: structure, function, and regulation during embryonic development and tissue remodeling. (PMID: 10842355) Jones F.S. … Jones P.L. (Dev. Dyn. 2000) 23 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67

Products for TNN Gene

Sources for TNN Gene

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