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Aliases for TNMD Gene

Aliases for TNMD Gene

  • Tenomodulin 2 3 5
  • Chondromodulin-1-Like Protein 3 4
  • Chondromodulin-I-Like Protein 3 4
  • BRICHOS Domain Containing 4 2 3
  • Myodulin 3 4
  • Tendin 3 4
  • HChM1L 3 4
  • CHM1L 3 4
  • HTeM 3 4
  • TEM 3 4
  • Chondromodulin-IB 3
  • BRICD4 3

External Ids for TNMD Gene

Previous GeneCards Identifiers for TNMD Gene

  • GC0XP095121
  • GC0XP096800
  • GC0XP097875
  • GC0XP098611
  • GC0XP099645
  • GC0XP099839
  • GC0XP089639

Summaries for TNMD Gene

Entrez Gene Summary for TNMD Gene

  • This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009]

GeneCards Summary for TNMD Gene

TNMD (Tenomodulin) is a Protein Coding gene. GO annotations related to this gene include chitin binding. An important paralog of this gene is LECT1.

UniProtKB/Swiss-Prot for TNMD Gene

  • May be an angiogenesis inhibitor.

Gene Wiki entry for TNMD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNMD Gene

Genomics for TNMD Gene

Regulatory Elements for TNMD Gene

Genomic Location for TNMD Gene

Chromosome:
X
Start:
100,584,793 bp from pter
End:
100,600,983 bp from pter
Size:
16,191 bases
Orientation:
Plus strand

Genomic View for TNMD Gene

Genes around TNMD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNMD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNMD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNMD Gene

Proteins for TNMD Gene

  • Protein details for TNMD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2S6-TNMD_HUMAN
    Recommended name:
    Tenomodulin
    Protein Accession:
    Q9H2S6
    Secondary Accessions:
    • Q9HBX0
    • Q9UJG0

    Protein attributes for TNMD Gene

    Size:
    317 amino acids
    Molecular mass:
    37130 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TNMD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNMD Gene

Proteomics data for TNMD Gene at MOPED

Post-translational modifications for TNMD Gene

  • Glycosylation at Asn 94 and Asn 180
  • Modification sites at PhosphoSitePlus

Other Protein References for TNMD Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TNMD Gene

Domains & Families for TNMD Gene

Gene Families for TNMD Gene

Protein Domains for TNMD Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TNMD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2S6

UniProtKB/Swiss-Prot:

TNMD_HUMAN :
  • Contains 1 BRICHOS domain.
  • Belongs to the chondromodulin-1 family.
Domain:
  • Contains 1 BRICHOS domain.
Family:
  • Belongs to the chondromodulin-1 family.
genes like me logo Genes that share domains with TNMD: view

Function for TNMD Gene

Molecular function for TNMD Gene

UniProtKB/Swiss-Prot Function:
May be an angiogenesis inhibitor.
genes like me logo Genes that share phenotypes with TNMD: view

Animal Models for TNMD Gene

MGI Knock Outs for TNMD:

Animal Model Products

  • Taconic Biosciences Mouse Models for TNMD

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TNMD Gene

Localization for TNMD Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNMD Gene

Isoform 1: Membrane; Single-pass type II membrane protein. Nucleus envelope.
Isoform 2: Membrane; Single-pass type II membrane protein. Nucleus envelope.
Isoform 3: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNMD Gene COMPARTMENTS Subcellular localization image for TNMD gene
Compartment Confidence
nucleus 5
plasma membrane 3
extracellular 2
cytoskeleton 1
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TNMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TNMD: view

Pathways & Interactions for TNMD Gene

SuperPathways for TNMD Gene

No Data Available

Interacting Proteins for TNMD Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362122%0d%0a9606.ENSP00000295694%0d%0a
Selected Interacting proteins: Q9H2S6-TNMD_HUMAN ENSP00000362122 for TNMD Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for TNMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001937 negative regulation of endothelial cell proliferation IEA --
GO:0035990 tendon cell differentiation IEA --
genes like me logo Genes that share ontologies with TNMD: view

No data available for Pathways by source and SIGNOR curated interactions for TNMD Gene

Drugs & Compounds for TNMD Gene

No Compound Related Data Available

Transcripts for TNMD Gene

Unigene Clusters for TNMD Gene

Tenomodulin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNMD Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: -
SP3:

Relevant External Links for TNMD Gene

GeneLoc Exon Structure for
TNMD
ECgene alternative splicing isoforms for
TNMD

Expression for TNMD Gene

mRNA expression in normal human tissues for TNMD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNMD Gene

This gene is overexpressed in Adipose - Subcutaneous (x15.6), Adipose - Visceral (Omentum) (x10.5), and Breast - Mammary Tissue (x7.7).

SOURCE GeneReport for Unigene cluster for TNMD Gene Hs.132957

mRNA Expression by UniProt/SwissProt for TNMD Gene

Q9H2S6-TNMD_HUMAN
Tissue specificity: Highly expressed in hypovascular connective tissues such as tendons. Has also strong expression in adipose tissue.
genes like me logo Genes that share expression patterns with TNMD: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TNMD Gene

Orthologs for TNMD Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNMD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TNMD 35
  • 93.27 (n)
  • 96.85 (a)
TNMD 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNMD 35
  • 94.11 (n)
  • 96.85 (a)
TNMD 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnmd 35
  • 91.59 (n)
  • 96.21 (a)
Tnmd 16
Tnmd 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNMD 35
  • 99.79 (n)
  • 99.68 (a)
TNMD 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnmd 35
  • 91.38 (n)
  • 94.64 (a)
oppossum
(Monodelphis domestica)
Mammalia TNMD 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNMD 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNMD 35
  • 62.99 (n)
  • 62.15 (a)
TNMD 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731375 35
  • 64.36 (n)
  • 57.57 (a)
zebrafish
(Danio rerio)
Actinopterygii tnmd 35
  • 55.17 (n)
  • 44.6 (a)
tnmd 36
  • 43 (a)
OneToOne
Species with no ortholog for TNMD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNMD Gene

ENSEMBL:
Gene Tree for TNMD (if available)
TreeFam:
Gene Tree for TNMD (if available)

Paralogs for TNMD Gene

Paralogs for TNMD Gene

(1) SIMAP similar genes for TNMD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNMD: view

Variants for TNMD Gene

Sequence variations from dbSNP and Humsavar for TNMD Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs932437 -- 100,582,877(+) AAGTC(C/G)AGATC upstream-variant-2KB
rs1055593 -- 100,599,810(+) GCCCC(A/T)GGTAG downstream-variant-500B, utr-variant-3-prime
rs1540914 -- 100,585,181(+) GCTTG(C/T)TTATT intron-variant
rs1155974 -- 100,598,284(+) TTACT(C/T)TATTA intron-variant
rs2073162 -- 100,594,020(+) GAAGT(A/G)CACGA reference, synonymous-codon

Variation tolerance for TNMD Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNMD Gene

HapMap Linkage Disequilibrium report
TNMD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TNMD Gene

Disorders for TNMD Gene

Relevant External Links for TNMD

Genetic Association Database (GAD)
TNMD
Human Genome Epidemiology (HuGE) Navigator
TNMD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNMD

No disorders were found for TNMD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNMD Gene

Publications for TNMD Gene

  1. Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss. (PMID: 19602561) Saiki A. … Carlsson L.M. (J. Clin. Endocrinol. Metab. 2009) 3 4 23 67
  2. Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration. (PMID: 19381347) Tolppanen A.M. … Pulkkinen L. (Mol. Vis. 2009) 3 23
  3. The genetic variation of the tenomodulin gene (TNMD) is associated with serum levels of systemic immune mediators--the Finnish Diabetes Prevention Study. (PMID: 18580688) Tolppanen A.M. … Uusitupa M. (Genet. Med. 2008) 3 23
  4. Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis. (PMID: 18838562) Kimura N. … Fukuda K. (Circulation 2008) 3 23
  5. The genetic variation in the tenomodulin gene is associated with serum total and LDL cholesterol in a body size-dependent manner. (PMID: 18982016) Tolppanen A.M. … Kuusisto J. (Int J Obes (Lond) 2008) 3 23

Products for TNMD Gene

Sources for TNMD Gene

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