Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TNMD Gene

Aliases for TNMD Gene

  • Tenomodulin 2 3
  • CHM1L 3 4 6
  • TEM 3 4 6
  • Chondromodulin-1-Like Protein 3 4
  • Chondromodulin-I-Like Protein 3 4
  • BRICHOS Domain Containing 4 2 3
  • Myodulin 3 4
  • Tendin 3 4
  • HChM1L 3 4
  • HTeM 3 4
  • Chondromodulin-IB 3
  • BRICD4 3

External Ids for TNMD Gene

Summaries for TNMD Gene

Entrez Gene Summary for TNMD Gene

  • This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009]

GeneCards Summary for TNMD Gene

TNMD (Tenomodulin) is a Protein Coding gene. Diseases associated with TNMD include mitral valve insufficiency and obesity. An important paralog of this gene is LECT1.

UniProtKB/Swiss-Prot for TNMD Gene

  • May be an angiogenesis inhibitor

Gene Wiki entry for TNMD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNMD Gene

Genomics for TNMD Gene

Genomic Location for TNMD Gene

Start:
100,584,793 bp from pter
End:
100,600,008 bp from pter
Size:
15,216 bases
Orientation:
Plus strand

Genomic View for TNMD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNMD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNMD Gene

Regulatory Elements for TNMD Gene

Proteins for TNMD Gene

  • Protein details for TNMD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2S6-TNMD_HUMAN
    Recommended name:
    Tenomodulin
    Protein Accession:
    Q9H2S6
    Secondary Accessions:
    • Q9HBX0
    • Q9UJG0

    Protein attributes for TNMD Gene

    Size:
    317 amino acids
    Molecular mass:
    37130 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TNMD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNMD Gene

Proteomics data for TNMD Gene at MOPED

Post-translational modifications for TNMD Gene

  • Glycosylation at Asn94 and Asn180

Other Protein References for TNMD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNMD Gene

Domains for TNMD Gene

Gene Families for TNMD Gene

HGNC:
  • BRICD :BRICHOS domain containing

Protein Domains for TNMD Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TNMD_HUMAN
Domain:
  • Contains 1 BRICHOS domain.:
    • Q9H2S6
Family:
  • Belongs to the chondromodulin-1 family.:
    • Q9H2S6
genes like me logo Genes that share domains with TNMD: view

Function for TNMD Gene

Molecular function for TNMD Gene

UniProtKB/Swiss-Prot Function: May be an angiogenesis inhibitor

Gene Ontology (GO) - Molecular Function for TNMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008061 chitin binding --
genes like me logo Genes that share ontologies with TNMD: view

Phenotypes for TNMD Gene

genes like me logo Genes that share phenotypes with TNMD: view

Animal Models for TNMD Gene

MGI Knock Outs for TNMD:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TNMD Gene

Localization for TNMD Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNMD Gene

Isoform 1: Membrane; Single-pass type II membrane protein. Nucleus envelope.
Isoform 2: Membrane; Single-pass type II membrane protein. Nucleus envelope.
Isoform 3: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNMD Gene COMPARTMENTS Subcellular localization image for TNMD gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TNMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope IEA --
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNMD: view

Pathways for TNMD Gene

SuperPathways for TNMD Gene

No Data Available

Interacting Proteins for TNMD Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362122%0d%0a9606.ENSP00000295694%0d%0a
Selected Interacting proteins: ENSP00000362122 Q9H2S6-TNMD_HUMAN for TNMD Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TNMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001886 endothelial cell morphogenesis IEA --
GO:0001937 negative regulation of endothelial cell proliferation IEA --
GO:0016525 negative regulation of angiogenesis IEA --
GO:0035990 tendon cell differentiation IEA --
GO:0071773 cellular response to BMP stimulus IEA --
genes like me logo Genes that share ontologies with TNMD: view

No data available for Pathways by source for TNMD Gene

Transcripts for TNMD Gene

Unigene Clusters for TNMD Gene

Tenomodulin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNMD Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: -
SP3:

Relevant External Links for TNMD Gene

GeneLoc Exon Structure for
TNMD
ECgene alternative splicing isoforms for
TNMD

Expression for TNMD Gene

mRNA expression in normal human tissues for TNMD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNMD Gene

This gene is overexpressed in Adipose - Subcutaneous (15.6), Adipose - Visceral (Omentum) (10.5), and Breast - Mammary Tissue (7.7).

SOURCE GeneReport for Unigene cluster for TNMD Gene Hs.132957

mRNA Expression by UniProt/SwissProt for TNMD Gene

Q9H2S6-TNMD_HUMAN
Tissue specificity: Highly expressed in hypovascular connective tissues such as tendons. Has also strong expression in adipose tissue.
genes like me logo Genes that share expressions with TNMD: view

Orthologs for TNMD Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNMD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNMD 36
  • 99.79 (n)
  • 99.68 (a)
TNMD 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNMD 36
  • 93.27 (n)
  • 96.85 (a)
TNMD 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNMD 36
  • 94.11 (n)
  • 96.85 (a)
TNMD 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnmd 36
  • 91.59 (n)
  • 96.21 (a)
Tnmd 16
Tnmd 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNMD 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNMD 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnmd 36
  • 91.38 (n)
  • 94.64 (a)
chicken
(Gallus gallus)
Aves TNMD 36
  • 62.99 (n)
  • 62.15 (a)
TNMD 37
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731375 36
  • 64.36 (n)
  • 57.57 (a)
zebrafish
(Danio rerio)
Actinopterygii tnmd 36
  • 55.17 (n)
  • 44.6 (a)
tnmd 37
  • 43 (a)
OneToOne
Species with no ortholog for TNMD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNMD Gene

ENSEMBL:
Gene Tree for TNMD (if available)
TreeFam:
Gene Tree for TNMD (if available)

Paralogs for TNMD Gene

Paralogs for TNMD Gene

Selected SIMAP similar genes for TNMD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNMD: view

Variants for TNMD Gene

Sequence variations from dbSNP and Humsavar for TNMD Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs932437 -- 100,582,877(+) AAGTC(C/G)AGATC upstream-variant-2KB
rs1055593 -- 100,599,810(+) GCCCC(A/T)GGTAG utr-variant-3-prime, downstream-variant-500B
rs1155974 -- 100,598,284(+) TTACT(C/T)TATTA intron-variant
rs1540914 -- 100,585,181(+) GCTTG(C/T)TTATT intron-variant
rs2073162 -- 100,594,020(+) GAAGT(A/G)CACGA synonymous-codon, reference

Relevant External Links for TNMD Gene

HapMap Linkage Disequilibrium report
TNMD
Locus Specific Mutation Databases (LSDB)
TNMD

No data available for Structural Variations from Database of Genomic Variants (DGV) for TNMD Gene

Disorders for TNMD Gene

(1) University of Copenhagen DISEASES for TNMD Gene

Relevant External Links for TNMD

Genetic Association Database (GAD)
TNMD
Human Genome Epidemiology (HuGE) Navigator
TNMD
genes like me logo Genes that share disorders with TNMD: view

No data available for UniProtKB/Swiss-Prot for TNMD Gene

Publications for TNMD Gene

  1. A novel gene, tendin, is strongly expressed in tendons and ligaments and shows high homology with chondromodulin-I. (PMID: 11357195) Brandau O. … Aszodi A. (Dev. Dyn. 2001) 3 4 23
  2. The genetic variation of the tenomodulin gene (TNMD) is associated with serum levels of systemic immune mediators--the Finnish Diabetes Prevention Study. (PMID: 18580688) Tolppanen A.M. … Uusitupa M. (Genet. Med. 2008) 3 23 49
  3. The genetic variation in the tenomodulin gene is associated with serum total and LDL cholesterol in a body size-dependent manner. (PMID: 18982016) Tolppanen A.M. … Kuusisto J. (Int J Obes (Lond) 2008) 3 23 49
  4. Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration. (PMID: 19381347) Tolppanen A.M. … Pulkkinen L. (Mol. Vis. 2009) 3 23 49
  5. Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss. (PMID: 19602561) Saiki A. … Carlsson L.M. (J. Clin. Endocrinol. Metab. 2009) 3 4 23

Products for TNMD Gene

Sources for TNMD Gene

Back to Top

Content