TNMD Gene
protein-coding GIFtS : 48
GCID: GC0X P099839
tenomodulin
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Aliasesfor TNMD gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Tenomodulin 1 Chondromodulin-I-Like Protein2 3 TEM1 2 5 HChM1L1 CHM1L2 3 5 HTeM1 BRICD41 2 BRICHOS Domain Containing 42 Myodulin3 Chondromodulin-IB1 Tendin3 Myodulin3 ChM1L1 3 TeM3 Chondromodulin-1-Like Protein2 3 Tendin3
Export aliases for TNMD gene to outside databases Previous GC identifers: GC0XP095121 GC0XP096800 GC0XP097875 GC0XP098611 GC0XP099645 GC0XP089639
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Summariesfor TNMD gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for TNMD : This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. (provided by RefSeq, Sep 2009) UniProtKB/Swiss-Prot: TNMD_HUMAN, Q9H2S6 Function : May be an angiogenesis inhibitorGene Wiki entry for TNMD
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Genomic Viewsfor TNMD gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_011651.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TNMD gene promoter: TBP GR-beta Nkx2-5 Tal-1beta E47 HNF-1A HNF-1 TFIID c-Myb GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for TNMD Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNMD
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xq21.33-q23 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq21.33-q23 TNMD Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XP099839: view genomic region
(about GC identifiers )
Start:
99,839,790 bp from pter
End:
99,854,882 bp from pter
Size:
15,093 bases
Orientation:
plus strand
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Proteinsfor TNMD gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TNMD_HUMAN, Q9H2S6 (See
protein sequence )Recommended Name: Tenomodulin Size : 317 amino acids; 37130 Da
Subcellular location : Membrane; Single-pass type II membrane protein (Potential)
Secondary accessions : Q9HBX0 Q9UJG0Explore the universe of human proteins at neXtProt for TNMD: NX_Q9H2S6 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9H2S6 TNMD Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_071427.2 ENSEMBL proteins: ENSP00000362122 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
TNMD for ontologies About GeneDecksing TNMD Antibody Products: Assay Products for TNMD:
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Protein
Domains / Familiesfor TNMD gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TNMD for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9H2S6 ProtoNet protein and cluster: Q9H2S6
1 Blocks protein family : IPB007084 BRICHOS domain UniProtKB/Swiss-Prot: TNMD_HUMAN, Q9H2S6 Similarity : Belongs to the chondromodulin-1 familySimilarity : Contains 1 BRICHOS domain
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Functionfor TNMD gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: TNMD_HUMAN, Q9H2S6 Function : May be an angiogenesis inhibitor
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TNMD (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TNMDOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TNMD (NM_022144 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNMD Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TNMD
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNMD
Animal Models: Mouse knock-out Tnmd tm1Ref for TNMD 3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tnmd) :
TNMD for phenotypes About GeneDecksing
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Pathways & Interactionsfor TNMD gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TNMD Gene Ontology (GO): 5 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0001886 endothelial cell morphogenesis
IEA -- GO:0001937 negative regulation of endothelial cell proliferation
IEA -- GO:0016525 negative regulation of angiogenesis
IEA -- GO:0035990 tendon cell differentiation
IEA -- GO:0071773 cellular response to BMP stimulus
IEA --
TNMD for ontologies About GeneDecksing
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Drugs & Compoundsfor TNMD gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TNMD Search CenterWatch for drugs/clinical trials and news about TNMD
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Transcriptsfor TNMD gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TNMD gene: NM_022144.2 Unigene Cluster for TNMD:
Tenomodulin Hs.132957 [show with all ESTs ] Unigene Representative Sequence: NM_022144 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000373031 (uc004efy.4 uc004efz.2 ) ENST00000485971 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TNMD (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TNMDOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TNMD (NM_022144 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNMD Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TNMD
Additional cDNA sequence: AB055421.1 AF191770.1 AF234259.1 AF291656.1 AY358706.1
3 DOTS entries : DT.405245 DT.99997264
DT.40129518 24 AceView cDNA sequences :
BX104255 AY358706 BQ934226 AF291656 BC034030 AB055421 AF234259 AI147044 BF439260 CB114632 CD103859 CD512100 NM_022144 AF191770 AI123839 AI146280 AA297231 AI039039 AA236166 T12180 AA236692 AW962409 AA453695 BF679243 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for TNMD About this scheme ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b SP1 :       -             SP2 :       -             SP3 :                  
ECgene alternative splicing isoforms for TNMD
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Expression for TNMD gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TNMD expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTATTCAATG
About this image TNMD expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See TNMD Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TNMD SOURCE GeneReport for Unigene cluster: Hs.132957 SABiosciences Custom PCR Arrays for TNMD Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TNMDBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TNMD QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TNMD QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TNMD In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNMD
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Orthologsfor TNMD gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for TNMD gene from 3/9 species (see all 9 ) About this table
ENSEMBL Gene Tree for TNMD (if available)TreeFam Gene Tree for TNMD (if available)
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Paralogsfor TNMD gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TNMD gene LECT1 2 1 SIMAP similar gene for TNMD using alignment to 1 protein entry: TNMD_HUMAN :LECT1
TNMD for paralogs About GeneDecksing
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Genomic Variantsfor TNMD gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TNMD (99839790 - 99854882 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TNMD: -- Locus Specific Mutation Databases (LSDB): TNMD
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TNMD
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Disorders
/ Diseasesfor TNMD gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TNMD for disorders About GeneDecksing
OMIM gene information: 300459
OMIM disorders : --8 diseases for TNMD : About MalaCards age related macular degeneration macular degeneration mitral valve insufficiency obesity dermatomyositis alzheimer's disease periodontitis cholesterol 1 disease from the University of Copenhagen DISEASES database for TNMD :Mitral valve insufficiency Human Genome Epidemiology (HuGE) Navigator: TNMD (4 documents) Export disorders for TNMD gene to outside databases
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Publicationsfor TNMD gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TNMD gene, integrated from 9 sources (see all 29 ): (articles sorted by number of sources associating them with TNMD) Utopia : connect your pdf to the dynamic world of online information
A novel gene, tendin, is strongly expressed in tendons and ligaments and shows high homology with chondromodulin-I. (PubMed id 11357195) 1 , 2 , 9 Brandau O.... Aszodi A. (2001) The DNA sequence of the human X chromosome. (PubMed id 15772651) 1 , 2 Ross M.T.... Bentley D.R. (2005) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) Molecular cloning and characterization of ChM1L, a novel membrane molecule similar to chondromodulin-I. (PubMed id 11162640) 1 , 2 Yamana K.... Kiyoki M. (2001) Molecular cloning of tenomodulin, a novel chondromodulin-I related gene. (PubMed id 11162673) 1 , 2 Shukunami C.... Hiraki Y. (2001) Tenomodulin is highly expressed in adipose tissue, in creased in obesity, and down-regulated during diet-induced weight loss. (PubMed id 19602561) 1 , 9 Saiki A....Carlsson L.M. (2009) Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration. (PubMed id 19381347) 1 , 9 Tolppanen A.M....Pulkkinen L. (2009) Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis. (PubMed id 18838562) 1 , 9 Kimura N....Fukuda K. (2008) The genetic variation of the tenomodulin gene (TNMD) is associated with serum levels of systemic immune mediators--the Finnish Diabetes Prevention Study. (PubMed id 18580688) 1 , 9 Tolppanen A.M....Uusitupa M. (2008) Anti-angiogenic action of the C-terminal domain of tenomodulin that shares homology with chondromodulin-I. (PubMed id 15150318) 1 , 9 Oshima Y....Shukunami C. (2004)
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External Searches for TNMD gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TNMD gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TNMD gene
(According to HUGE )
About This Section --
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Specialized Databases showing TNMD gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TNMD Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TNMD gene: Search GeneIP for patents involving TNMD GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TNMD gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TNMD OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TNMD OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TNMD OriGene Protein Over-expression Lysate for TNMD Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TNMD Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TNMD OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TNMD Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for TNMD OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TNMD QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TNMD QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNMD QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TNMD QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TNMD QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TNMD
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Aliases for TNMD
Databases for TNMD
Disorders / Diseases for TNMD
Domains / Families for TNMD
Drugs / Compounds for TNMD
Expression for TNMD
Function for TNMD
Genomic Views for TNMD
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Orthologs for TNMD
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Pathways / Interactions for TNMD
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