Aliases for TNKS2 Gene
- Tankyrase 2 2 3 5
- TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 2 3 4
- Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 2 3
- ADP-Ribosyltransferase Diphtheria Toxin-Like 6 3 4
- Poly [ADP-Ribose] Polymerase 5B 3 4
- Tankyrase-Related Protein 3 4
- Tankyrase-Like Protein 3 4
- Tankyrase II 3 4
- PARP5B 3 4
- TNKS-2 3 4
External Ids for TNKS2 Gene
Previous GeneCards Identifiers for TNKS2 Gene
GeneCards Summary for TNKS2 Gene
TNKS2 (Tankyrase 2) is a Protein Coding gene. Among its related pathways are Signaling by Wnt and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include enzyme binding and NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is TNKS.
UniProtKB/Swiss-Prot for TNKS2 Gene
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.
The Tankyrases (TNKS1/PARP5A and TNKS2/PARP5B) are poly (ADP-ribose) polymerases that catalyze the ADP-ribosylation of target proteins. TNKS' are involved in the regulation of Wnt/beta-catenin signaling and have been implicated in the pathology of various forms of cancer.