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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNKS2 Gene

protein-coding   GIFtS: 62
GCID: GC10P093548

Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 21 2     ADP-Ribosyltransferase Diphtheria Toxin-Like 62 3
Poly [ADP-Ribose] Polymerase 5B2 3     TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 22 3
Tankyrase II2 3     PARP-5b2
Tankyrase-Like Protein2 3     PARP-5c2
Tankyrase-Related Protein2 3     PARP5C2
ARTD62 3     pART62
PARP5B2 3     Tankyrase 22
TANK22 3     tankyrase-22
TNKL2 3     EC 2.4.2.303
TNKS-22 3     

External Ids:    HGNC: 156771   Entrez Gene: 803512   Ensembl: ENSG000001078547   OMIM: 6071285   UniProtKB: Q9H2K23   

Export aliases for TNKS2 gene to outside databases

Previous GC identifers: GC10P092439 GC10P092779 GC10P093689 GC10P093222 GC10P087186


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TNKS2 Gene: 
TNKS2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2) is a protein-coding gene. Diseases associated with TNKS2 include cherubism, and diphtheria, and among its related super-pathways are Apoptotic Pathways in Synovial Fibroblasts and Nicotinate and nicotinamide metabolism. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and enzyme binding. An important paralog of this gene is ANK3.

UniProtKB/Swiss-Prot: TNKS2_HUMAN, Q9H2K2
Function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length
and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of
AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins
are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates
poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination.
Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also
regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles

summary for TNKS2 Gene:
Tankyrases 1 and 2 (TNKS1/PARP5A and TNKS2/PARP5B/PARP5C) are proteins with poly(ADP-ribose) polymerase
activity. Human tankyrases post-translationally modify multiple proteins involved in processes including
maintenance of telomere length, sister telomere association, insulin responsiveness, spindle assembly and
trafficking of glut4-containing vesicles. Recently tankyrases have been shown be involved in the wnt
signaling pathway. Tankyrases bind directly to axin, a member of the 'destruction complex' involved in
beta-catenin degradation. Inhibition of tankyrase stabilizes axin, increases the activity of the destruction
complex and promotes degradation of beta-catenin. Tankyrases are therefore an attractive target anticancer
therapies.

Gene Wiki entry for TNKS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNKS2 gene promoter:
         AhR   STAT1   Pax-5   STAT3   STAT1beta   Meis-1a   TGIF   Meis-1   Meis-1b   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNKS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNKS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNKS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.3   Ensembl cytogenetic band:  10q23.32   HGNC cytogenetic band: 10q23.3

TNKS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNKS2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P093548:  view genomic region     (about GC identifiers)

Start:
93,558,069 bp from pter      End:
93,625,232 bp from pter
Size:
67,164 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNKS2_HUMAN, Q9H2K2 (See protein sequence)
Recommended Name: Tankyrase-2  
Size: 1166 amino acids; 126918 Da
Subunit: Oligomerizes and associates with TNKS. Interacts with the cytoplasmic domain of LNPEP/Otase in
SLC2A4/GLUT4-vesicles. Binds to the N-terminus of Grb14 and TRF1 with its ankyrin repeat region. Interacts with
HIF1AN. Interacts with RNF146; this interaction leads to ubiquitination and proteasomal degradation
Subcellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome,
telomere (Potential). Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found
around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in
the nucleus, associated with TRF1
Sequence caution: Sequence=AAG25674.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB14665.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
6/32 PDB 3D structures from and Proteopedia for TNKS2 (see all 32):
2Y0I (3D)        3KR7 (3D)        3KR8 (3D)        3MHJ (3D)        3MHK (3D)        3P0N (3D)    
Secondary accessions: B2RBD3 Q9H8F2 Q9HAS4

Explore the universe of human proteins at neXtProt for TNKS2: NX_Q9H2K2

Explore proteomics data for TNKS2 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated; this leads to degradation
  • UniProtKB: ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination
  • UniProtKB: The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H2K2

  • TNKS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNKS2 Protein Expression
    REFSEQ proteins: NP_079511.1  
    ENSEMBL proteins: 
     ENSP00000360689  

    Human Recombinant Protein Products for TNKS2: 
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    Novus Biologicals TNKS2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNKS2 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0000242pericentriolar material IDA11454873
    GO:0000784nuclear chromosome, telomeric region IC11739745
    GO:0005634nucleus IDA11739745
    GO:0005635nuclear envelope IDA11454873

    TNKS2 for ontologies           About GeneDecksing



    TNKS2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for TNKS2 

    Assay Products for TNKS2: 
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    Cloud-Clone Corp. ELISAs for TNKS2 
    Cloud-Clone Corp. CLIAs for TNKS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PARP: Poly (ADP-ribose) polymerases
    ANKRD: Ankyrin repeat domain containing
    SAMD: Sterile alpha motif (SAM) domain containing

    5/6 InterPro protein domains (see all 6):
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR011510 SAM_2
     IPR020683 Ankyrin_rpt-contain_dom
     IPR012317 Poly(ADP-ribose)pol_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9H2K2

    ProtoNet protein and cluster: Q9H2K2

    2 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: TNKS2_HUMAN, Q9H2K2
    Similarity: Contains 15 ANK repeats
    Similarity: Contains 1 PARP catalytic domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    TNKS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNKS2_HUMAN, Q9H2K2
    Function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length
    and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of
    AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins
    are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates
    poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination.
    Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also
    regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles
    Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
    Enzyme regulation: Specifically inhibited by XAV939, a small molecule, leading to inhibit the Wnt signaling
    pathway by stabilizing AXIN1 and AXIN2

         Enzyme Number (IUBMB): EC 2.4.2.301

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NAD+ ADP-ribosyltransferase activity IDA11739745
    GO:0005515protein binding IPI19759537
    GO:0019899enzyme binding IPI--
    GO:0046872metal ion binding IEA--
         
    TNKS2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TNKS2:
     High actin ratio cells 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tnks2):
     adipose tissue  cardiovascular system  cellular  embryogenesis  growth/size 
     mortality/aging 

    TNKS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TNKS2: Tnks2tm1Susm Tnks2tm1.1Yjc Tnks2tm1.1Susm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNKS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNKS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNKS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNKS2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNKS2
    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate TNKS2 (see all 83):
    hsa-miR-548j hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-520e hsa-miR-106a hsa-miR-200a hsa-miR-374a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidTNKS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TNKS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNKS2

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of TNKS2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: TNKS2 (NM_025235)
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    Sirion Biotech Customized lentivirus for stable overexpression of TNKS2 
                         Customized lentivirus expression plasmids for stable overexpression of TNKS2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNKS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNKS2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Apoptotic Pathways in Synovial Fibroblasts
    Telomerase Components in Cell Signaling0.72
    2NAD metabolism
    NAD metabolism0.43
    3Telomere Extension by Telomerase
    Telomere Extension by Telomerase

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TNKS2
        NAD metabolism

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNKS2
        Telomerase Components in Cell Signaling
    Telomere Extension by Telomerase

    1 GeneGo (Thomson Reuters) Pathway for TNKS2
        NAD metabolism




    TNKS2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNKS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for TNKS2 (Q9H2K21, 2, 3 ENSP000003606894) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIF1ANQ9NWT62, 3, ENSP000002991634MINT-8084814 MINT-8084841 MINT-8084829 MINT-8084940 I2D: score=1 STRING: ENSP00000299163
    TERF1P542741, 3, ENSP000002766034EBI-4398527,EBI-710997 I2D: score=2 STRING: ENSP00000276603
    ZNF512BQ96KM62, 3MINT-60802 I2D: score=2 
    SH3BP2P783141, 3, ENSP000003486854EBI-4398527,EBI-727062 I2D: score=1 STRING: ENSP00000348685
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA19759537
    GO:0006471protein ADP-ribosylation IDA11739745
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0032212positive regulation of telomere maintenance via telomerase IC11739745
    GO:0035264multicellular organism growth IEA--

    TNKS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for TNKS2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for TNKS2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    WIKI4Tankyrase inhibitor; inhibits Wnt signaling[838818-26-1]
    NU 1025Potent PARP inhibitor[90417-38-2]
    XAV 939Tankyrase inhibitor; inhibits Wnt signaling[284028-89-3]
    JW 55Tankyrase inhibitor; inhibits canonical Wnt signaling[664993-53-7]
    PJ 34 hydrochloridePotent PARP inhibitor[344458-15-7]

    3 HMDB Compounds for TNKS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--

    Search CenterWatch for drugs/clinical trials and news about TNKS2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNKS2 gene: 
    NM_025235.3  

    Unigene Cluster for TNKS2:

    Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
    Hs.329327  [show with all ESTs]
    Unigene Representative Sequence: NM_025235
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371627(uc001khp.3)

    miRNA
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    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate TNKS2 (see all 83):
    hsa-miR-548j hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-520e hsa-miR-106a hsa-miR-200a hsa-miR-374a hsa-miR-93
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNKS2

    Additional mRNA sequence: 

    AF264912.1 AF305081.1 AF309033.1 AF329696.1 AF342982.1 AF438201.1 AK023746.1 AK314612.1 
    AL833676.1 BC023218.1 

    12 DOTS entries:

    DT.442059  DT.97843809  DT.407023  DT.95369691  DT.100000975  DT.100757443  DT.102829799  DT.40212400 
    DT.97767748  DT.121248017  DT.91790763  DT.91938943 

    24/201 AceView cDNA sequences (see all 201):

    AW173142 AA970617 AI935063 T25153 BM464678 CK429276 AA307492 AW027833 
    AF309033 BU581343 BX103336 AF329696 AW238878 BP376193 BM835034 AA721381 
    BU625551 AI040839 N73890 BQ718074 AI381961 CA447138 AI444969 N57467 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TNKS2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                                              -                                                               
    SP2:              -                                                                                                               
    SP3:                                                                                                                              
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for TNKS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNKS2 expression in normal human tissues (normalized intensities)      TNKS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATAGCTTA
    TNKS2 Expression
    About this image


    TNKS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Limb Bud
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             BONE MARROW   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             fetal cartilage   
     
     Placenta (Extraembryonic Tissues)
             placenta   
     
     Uterus (Reproductive System)
             endometrial endothelial cell   

    See TNKS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNKS2

    SOURCE GeneReport for Unigene cluster: Hs.329327

    UniProtKB/Swiss-Prot: TNKS2_HUMAN, Q9H2K2
    Tissue specificity: Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal
    cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine,
    colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal
    liver, heart and brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNKS2: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TNKS2 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnks21 , 5 tankyrase, TRF1-interacting ankyrin-related ADP-ribose more1, 5 90.74(n)1
    97.26(a)1
      19 (31.96 cM)5
    744931  NM_001163635.11  NP_001157107.11 
     368342325 
    chicken
    (Gallus gallus)
    Aves TNKS21 tankyrase, TRF1-interacting ankyrin-related ADP-ribose more 82.93(n)
    94.07(a)
      374253  NM_204341.1  NP_989672.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNKS26
    Uncharacterized protein
    91(a)
    1 ↔ 1
    GL343219.1(1110852-1153980)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.143552 Xenopus laevis transcribed sequence with moderate similarity more 74.4(n)    BU904301.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD225483
    tankyrase1
    cytoskeletal anchoring structural
    constituent more3
    CG4719-PA1
    64(a)3
    60.05(n)1
    67.46(a)1
      430951  NM_143153.21  NP_651410.11 


    ENSEMBL Gene Tree for TNKS2 (if available)
    TreeFam Gene Tree for TNKS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNKS2 gene
    ANK32  TRPA12  ANK12  ANKRD522  TNKS2  ANKRD652  ANKRD502  ANKFY12  
    INVS2  ANK22  ANKRD282  
    3 SIMAP similar genes for TNKS2 using alignment to 1 protein entry:     TNKS2_HUMAN:
    TNKS    CDKN2A    CDKN2B

    TNKS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1361 SNPs in TNKS2 are shown (see all 1361)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828860811,2
    --93560009(+) GCTGCC/TGTTCT 1 -- int10--------
    rs618746961,2
    C,F--93560104(+) TAAGCC/TAAAGG 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1874854191,2
    --93560292(+) CCCACC/GTTCAG 1 -- int10--------
    rs1135883381,2
    C,F--93560330(+) TTTTAC/TATAGG 1 -- int12Minor allele frequency- T:0.02CSA WA 120
    rs784913451,2
    F--93560402(+) TACCCA/TAATTA 1 -- int11Minor allele frequency- T:0.02NA 120
    rs1419594841,2
    C--93560435(+) GAGTT-/AAAAGG 1 -- int10--------
    rs1911148811,2
    --93560451(+) AAAGGA/GAGTAA 1 -- int10--------
    rs1832987101,2
    --93560665(+) AGTTAC/TCAGTC 1 -- int10--------
    rs1145467001,2
    F--93560689(+) TGCAAG/ACATAC 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1876358331,2
    --93560914(+) TTCGTG/TCAGAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TNKS2 (93558069 - 93625232 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TNKS2: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607128    OMIM disorders: --

    15 diseases for TNKS2:    About MalaCards
    cherubism    diphtheria    cerebrovascular disease    meningioma
    chronic lymphocytic leukemia    cervical cancer    hypoxia    hepatitis b
    alzheimer's disease    pancreatitis    cervicitis    hepatitis
    leukemia    breast cancer    prostatitis


    TNKS2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for TNKS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0.976 5 16151859 (4), 11294570 (1)
    necrosis 0 1 11454873 (1)

    Genetic Association Database (GAD): TNKS2
    Human Genome Epidemiology (HuGE) Navigator: TNKS2 (7 documents)

    Export disorders for TNKS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNKS2 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with TNKS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. (PubMed id 11454873)1, 2, 9 Kaminker P.G.... Campisi J. (2001)
    2. Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). (PubMed id 11802774)1, 2, 9 Sbodio J.I.... Chi N.-W. (2002)
    3. Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. (PubMed id 11739745)1, 2, 9 Cook B.D.... Smith S. (2002)
    4. Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14. (PubMed id 11278563)1, 2, 9 Lyons R.J.... Daly R.J. (2001)
    5. Polymorphisms in telomere-associated genes, breast ca ncer susceptibility and prognosis. (PubMed id 19766477)1, 4, 9 Varadi V....FAPrsti A. (2009)
    6. Cloning and characterization of TNKL, a member of tankyrase gene family. (PubMed id 11294570)1, 2, 9 Kuimov A.N.... Nedospasov S.A. (2001)
    7. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. (PubMed id 19759537)1, 2, 9 Huang S.M....Cong F. (2009)
    8. Novel tankyrase-related gene detected with meningioma-specific sera. (PubMed id 11205898)1, 2, 9 Monz D.... Meese E.U. (2001)
    9. Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Hea lth Study. (PubMed id 20937264)1, 4 Zee R.Y....Chasman D.I. (2011)
    10. Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling. (PubMed id 21799911)1, 2 Callow M.G....Costa M. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80351 HGNC: 15677 AceView: TNKS2 Ensembl:ENSG00000107854 euGenes: HUgn80351
    ECgene: TNKS2 H-InvDB: TNKS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNKS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNKS2 gene:
    Search GeneIP for patents involving TNKS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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