Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TNKS2 Gene

protein-coding   GIFtS: 64
GCID: GC10P093548

Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 21 2     ADP-Ribosyltransferase Diphtheria Toxin-Like 62 3
Poly [ADP-Ribose] Polymerase 5B2 3     TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 22 3
Tankyrase II2 3     PARP-5b2
Tankyrase-Like Protein2 3     PARP-5c2
Tankyrase-Related Protein2 3     PARP5C2
ARTD62 3     pART62
PARP5B2 3     Tankyrase 22
TANK22 3     tankyrase-22
TNKL2 3     EC 2.4.2.303
TNKS-22 3     

External Ids:    HGNC: 156771   Entrez Gene: 803512   Ensembl: ENSG000001078547   OMIM: 6071285   UniProtKB: Q9H2K23   

Export aliases for TNKS2 gene to outside databases

Previous GC identifers: GC10P092439 GC10P092779 GC10P093689 GC10P093222 GC10P087186


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TNKS2 Gene:
TNKS2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2) is a protein-coding gene. Diseases associated with TNKS2 include cherubism, and diphtheria. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and enzyme binding. An important paralog of this gene is ANK3.

UniProtKB/Swiss-Prot: TNKS2_HUMAN, Q9H2K2
Function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length
and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of
AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins
are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates
poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination.
Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also
regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S
proteasome activity

summary for TNKS2 Gene:
Tankyrases 1 and 2 (TNKS1/PARP5A and TNKS2/PARP5B/PARP5C) are proteins with poly(ADP-ribose) polymerase
activity. Human tankyrases post-translationally modify multiple proteins involved in processes including
maintenance of telomere length, sister telomere association, insulin responsiveness, spindle assembly and
trafficking of glut4-containing vesicles. Recently tankyrases have been shown be involved in the wnt
signaling pathway. Tankyrases bind directly to axin, a member of the 'destruction complex' involved in
beta-catenin degradation. Inhibition of tankyrase stabilizes axin, increases the activity of the destruction
complex and promotes degradation of beta-catenin. Tankyrases are therefore an attractive target anticancer
therapies.

Gene Wiki entry for TNKS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNKS2 gene promoter:
         AhR   STAT1   Pax-5   STAT3   STAT1beta   Meis-1a   TGIF   Meis-1   Meis-1b   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNKS2 promoter sequence
   Search Chromatin IP Primers for TNKS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNKS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.3   Ensembl cytogenetic band:  10q23.32   HGNC cytogenetic band: 10q23.3

TNKS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNKS2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P093548:  view genomic region     (about GC identifiers)

Start:
93,558,069 bp from pter      End:
93,625,232 bp from pter
Size:
67,164 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TNKS2_HUMAN, Q9H2K2 (See protein sequence)
Recommended Name: Tankyrase-2  
Size: 1166 amino acids; 126918 Da
Subunit: Oligomerizes and associates with TNKS. Interacts with the cytoplasmic domain of LNPEP/Otase in
SLC2A4/GLUT4-vesicles. Binds to the N-terminus of Grb14 and TRF1 with its ankyrin repeat region. Interacts with
HIF1AN. Interacts with RNF146; this interaction leads to ubiquitination and proteasomal degradation
Sequence caution: Sequence=AAG25674.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB14665.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Selected PDB 3D structures from and Proteopedia for TNKS2 (see all 79):
2Y0I (3D)        3KR7 (3D)        3KR8 (3D)        3MHJ (3D)        3MHK (3D)        3P0N (3D)    
Secondary accessions: B2RBD3 Q9H8F2 Q9HAS4

Explore the universe of human proteins at neXtProt for TNKS2: NX_Q9H2K2

Explore proteomics data for TNKS2 at MOPED

Post-translational modifications: 

  • Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated; this leads to degradation1
  • ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination1
  • The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer1
  • Ubiquitination2 at Lys225, Lys331, Lys398, Lys425, Lys510
  • Modification sites at PhosphoSitePlus

  • See TNKS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079511.1  
    ENSEMBL proteins: 
     ENSP00000360689  
    Reactome Protein details: Q9H2K2

    TNKS2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TNKS2
    GenScript Custom Purified and Recombinant Proteins Services for TNKS2
    Novus Biologicals TNKS2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNKS2

    TNKS2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TNKS2
    OriGene Custom Antibody Services for TNKS2
    Novus Biologicals TNKS2 Antibodies
    Abcam antibodies for TNKS2
    Cloud-Clone Corp. Antibodies for TNKS2
    ThermoFisher Antibodies for TNKS2
    LSBio Antibodies in human, mouse, rat for TNKS2

    TNKS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TNKS2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TNKS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TNKS2
    Cloud-Clone Corp. CLIAs for TNKS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PARP: Poly (ADP-ribose) polymerases
    ANKRD: Ankyrin repeat domain containing
    SAMD: Sterile alpha motif (SAM) domain containing

    Selected InterPro protein domains (see all 6):
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR011510 SAM_2
     IPR020683 Ankyrin_rpt-contain_dom
     IPR012317 Poly(ADP-ribose)pol_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9H2K2

    ProtoNet protein and cluster: Q9H2K2

    2 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: TNKS2_HUMAN, Q9H2K2
    Similarity: Contains 15 ANK repeats
    Similarity: Contains 1 PARP catalytic domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    TNKS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNKS2_HUMAN, Q9H2K2
    Function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length
    and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of
    AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins
    are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates
    poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination.
    Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also
    regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S
    proteasome activity
    Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
    Enzyme regulation: Specifically inhibited by XAV939, a small molecule, leading to inhibit the Wnt signaling
    pathway by stabilizing AXIN1 and AXIN2

         Enzyme Number (IUBMB): EC 2.4.2.301

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NAD+ ADP-ribosyltransferase activity IDA11739745
    GO:0005515protein binding IPI19759537
    GO:0019899enzyme binding IPI--
    GO:0046872metal ion binding IEA--
         
    TNKS2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TNKS2:
     High actin ratio cells 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tnks2):
     adipose tissue  cellular  embryogenesis  growth/size/body  integument 
     mortality/aging 

    TNKS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TNKS2: Tnks2tm1Susm Tnks2tm1.1Yjc Tnks2tm1.1Susm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNKS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNKS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNKS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNKS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TNKS2:
    hsa-mir-30e-5p (MIRT044139), hsa-mir-31-3p (MIRT038941), hsa-mir-221-3p (MIRT046944), hsa-mir-335-5p (MIRT018499), hsa-mir-454-5p (MIRT039255)

    Block miRNA regulation of human, mouse, rat TNKS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNKS2 (see all 83):
    hsa-miR-548j hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-520e hsa-miR-106a hsa-miR-200a hsa-miR-374a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidTNKS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TNKS2
    Predesigned siRNA for gene silencing in human, mouse, rat TNKS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TNKS2

    Clone
    Products:
         
    OriGene clones in human, mouse for TNKS2 (see all 6)
    OriGene ORF clones in mouse, rat for TNKS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNKS2 (NM_025235)
    Sino Biological Human cDNA Clone for TNKS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNKS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNKS2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TNKS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for TNKS2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNKS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TNKS2_HUMAN, Q9H2K2: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome,
    telomere (Potential). Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found
    around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in
    the nucleus, associated with TRF1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus5
    cytoskeleton4
    cytosol2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0000242pericentriolar material IDA11454873
    GO:0000784nuclear chromosome, telomeric region IC11739745
    GO:0005634nucleus IDA11739745
    GO:0005635nuclear envelope IDA11454873

    TNKS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TNKS2 About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptotic Pathways in Synovial Fibroblasts
    Telomerase Components in Cell Signaling0.72
    2Nicotinate and nicotinamide metabolism
    NAD metabolism0.43
    3Telomere Extension by Telomerase
    Telomere Extension by Telomerase

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNKS2
        Telomerase Components in Cell Signaling
    Telomere Extension by Telomerase

    1 GeneGo (Thomson Reuters) Pathway for TNKS2
        NAD metabolism


    2 Reactome Pathways for TNKS2
        degradation of AXIN
    TCF dependent signaling in response to WNT



    TNKS2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNKS2: 
              Cancer PathwayFinder in human mouse rat
              Telomeres & Telomerase in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNKS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNKS2 (Q9H2K21, 2, 3 ENSP000003606894) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIF1ANQ9NWT61, 2, 3, ENSP000002991634EBI-4398527,EBI-745632 MINT-8084814 MINT-8084841 MINT-8084829 MINT-8084940 I2D: score=1 STRING: ENSP00000299163
    TERF1P542741, 3, ENSP000002766034EBI-4398527,EBI-710997 I2D: score=2 STRING: ENSP00000276603
    ZNF512BQ96KM62, 3MINT-60802 I2D: score=2 
    SH3BP2P783141, 3, ENSP000003486854EBI-4398527,EBI-727062 I2D: score=1 STRING: ENSP00000348685
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA19759537
    GO:0006471protein ADP-ribosylation IDA11739745
    GO:0016055Wnt signaling pathway IEA--
    GO:0032212positive regulation of telomere maintenance via telomerase IC11739745
    GO:0035264multicellular organism growth IEA--

    TNKS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for TNKS2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    WIKI4Tankyrase inhibitor; inhibits Wnt signaling[838818-26-1]
    NU 1025Potent PARP inhibitor[90417-38-2]
    XAV 939Tankyrase inhibitor; inhibits Wnt signaling[284028-89-3]
    JW 55Tankyrase inhibitor; inhibits canonical Wnt signaling[664993-53-7]
    PJ 34 hydrochloridePotent PARP inhibitor[344458-15-7]

    3 HMDB Compounds for TNKS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TNKS2 gene: 
    NM_025235.3  

    Unigene Cluster for TNKS2:

    Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
    Hs.329327  [show with all ESTs]
    Unigene Representative Sequence: NM_025235
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371627(uc001khp.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TNKS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNKS2 (see all 83):
    hsa-miR-548j hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-520e hsa-miR-106a hsa-miR-200a hsa-miR-374a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidTNKS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TNKS2
    Predesigned siRNA for gene silencing in human, mouse, rat TNKS2
    Clone
    Products:
         
    OriGene clones in human, mouse for TNKS2 (see all 6)
    OriGene ORF clones in mouse, rat for TNKS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNKS2 (NM_025235)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNKS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNKS2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TNKS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNKS2
      QuantiTect SYBR Green Assays in human, mouse, rat TNKS2
      QuantiFast Probe-based Assays in human, mouse, rat TNKS2

    Additional mRNA sequence: 

    AF264912.1 AF305081.1 AF309033.1 AF329696.1 AF342982.1 AF438201.1 AK023746.1 AK314612.1 
    AL833676.1 BC023218.1 

    12 DOTS entries:

    DT.442059  DT.97843809  DT.407023  DT.95369691  DT.100000975  DT.100757443  DT.102829799  DT.40212400 
    DT.97767748  DT.121248017  DT.91790763  DT.91938943 

    Selected AceView cDNA sequences (see all 201):

    BQ718074 CB242896 AA995110 AW173142 BM464678 BX107856 AI935063 T17118 
    AL833676 AI381961 BM835034 T25153 CR595012 N57467 AA721381 BX103336 
    CA447138 AA307492 T55578 AF329696 AW238878 BU581343 BP376193 AF342982 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TNKS2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                                              -                                                               
    SP2:              -                                                                                                               
    SP3:                                                                                                                              
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for TNKS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TNKS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATAGCTTA
    TNKS2 Expression
    About this image


    TNKS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Limb Bud
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    TNKS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNKS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.329327

    UniProtKB/Swiss-Prot: TNKS2_HUMAN, Q9H2K2
    Tissue specificity: Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal
    cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine,
    colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal
    liver, heart and brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNKS2: 
              Cancer PathwayFinder in human mouse rat
              Telomeres & Telomerase in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TNKS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNKS2
    QuantiTect SYBR Green Assays in human, mouse, rat TNKS2
    QuantiFast Probe-based Assays in human, mouse, rat TNKS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNKS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TNKS2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnks21 , 5 tankyrase, TRF1-interacting ankyrin-related ADP-ribose more1, 5 90.69(n)1
    97.37(a)1
      19 (31.96 cM)5
    744931  NM_001163635.11  NP_001157107.11 
     368342325 
    chicken
    (Gallus gallus)
    Aves TNKS21 tankyrase, TRF1-interacting ankyrin-related ADP-ribose more 83.23(n)
    94.56(a)
      374253  NM_204341.1  NP_989672.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNKS26
    tankyrase, TRF1-interacting ankyrin-related ADP-ri...
    92(a)
    1 ↔ 1
    GL343219.1(1110852-1153980)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.143552 Xenopus laevis transcribed sequence with moderate similarity more 74.4(n)    BU904301.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD225483 cytoskeletal anchoring structural
    constituent more
    64(a)     --


    ENSEMBL Gene Tree for TNKS2 (if available)
    TreeFam Gene Tree for TNKS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TNKS2 gene
    ANK32  ANK12  ANKRD522  TNKS2  ANKRD652  ANKFY12  ANKRD502  INVS2  
    ANK22  ANKRD282  
    3 SIMAP similar genes for TNKS2 using alignment to 1 protein entry:     TNKS2_HUMAN:
    TNKS    CDKN2A    CDKN2B

    TNKS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TNKS2 (see all 1361)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828860811,2
    --93560009(+) GCTGCC/TGTTCT 1 -- int10--------
    rs618746961,2
    C,F--93560104(+) TAAGCC/TAAAGG 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1874854191,2
    --93560292(+) CCCACC/GTTCAG 1 -- int10--------
    rs1135883381,2
    C,F--93560330(+) TTTTAC/TATAGG 1 -- int12Minor allele frequency- T:0.02CSA WA 120
    rs784913451,2
    F--93560402(+) TACCCA/TAATTA 1 -- int11Minor allele frequency- T:0.02NA 120
    rs1419594841,2
    C--93560435(+) GAGTT-/AAAAGG 1 -- int10--------
    rs1911148811,2
    --93560451(+) AAAGGA/GAGTAA 1 -- int10--------
    rs1832987101,2
    --93560665(+) AGTTAC/TCAGTC 1 -- int10--------
    rs1145467001,2
    F--93560689(+) TGCAAG/ACATAC 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1876358331,2
    --93560914(+) TTCGTG/TCAGAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TNKS2 (93558069 - 93625232 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TNKS2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNKS2
    DNA2.0 Custom Variant and Variant Library Synthesis for TNKS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607128    OMIM disorders: --

    17 diseases for TNKS2:    
    About MalaCards
    cherubism    diphtheria    cerebrovascular disease    meningioma
    cervical cancer    chronic lymphocytic leukemia    cervicitis    hypoxia
    hepatitis b    alzheimer's disease    hepatitis    pancreatitis
    leukemia    breast cancer    malaria    prostatitis
    endotheliitis


    TNKS2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TNKS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0.976 5 16151859 (4), 11294570 (1)
    necrosis 0 1 11454873 (1)

    Genetic Association Database (GAD): TNKS2
    Human Genome Epidemiology (HuGE) Navigator: TNKS2 (7 documents)

    Export disorders for TNKS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TNKS2 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with TNKS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. (PubMed id 11454873)1, 2, 9 Kaminker P.G.... Campisi J. (J. Biol. Chem. 2001)
    2. Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). (PubMed id 11802774)1, 2, 9 Sbodio J.I.... Chi N.-W. (Biochem. J. 2002)
    3. Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. (PubMed id 11739745)1, 2, 9 Cook B.D.... Smith S. (Mol. Cell. Biol. 2002)
    4. Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14. (PubMed id 11278563)1, 2, 9 Lyons R.J.... Daly R.J. (J. Biol. Chem. 2001)
    5. Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis. (PubMed id 19766477)1, 4, 9 Varadi V....FAPrsti A. (Eur. J. Cancer 2009)
    6. Cloning and characterization of TNKL, a member of tankyrase gene family. (PubMed id 11294570)1, 2, 9 Kuimov A.N.... Nedospasov S.A. (Genes Immun. 2001)
    7. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. (PubMed id 19759537)1, 2, 9 Huang S.M.... Cong F. (Nature 2009)
    8. Novel tankyrase-related gene detected with meningioma-specific sera. (PubMed id 11205898)1, 2, 9 Monz D.... Meese E.U. (Clin. Cancer Res. 2001)
    9. Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health Study. (PubMed id 20937264)1, 4 Zee R.Y....Chasman D.I. ( international journal of clinical chemistry 2011)
    10. Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling. (PubMed id 21799911)1, 2 Callow M.G.... Costa M. (PLoS ONE 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 80351 HGNC: 15677 AceView: TNKS2 Ensembl:ENSG00000107854 euGenes: HUgn80351
    ECgene: TNKS2 H-InvDB: TNKS2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TNKS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TNKS2 gene:
    Search GeneIP for patents involving TNKS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TNKS2   OriGene RNAi products in human, mouse, rat for TNKS2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TNKS2  
     OriGene qSTAR qPCR primer pairs in human, mouse for TNKS2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TNKS2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TNKS2   OriGene Custom Protein Services for TNKS2  

     
     
     Block miRNA regulation of human, mouse, rat TNKS2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TNKS2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNKS2 Predesigned siRNA for gene silencing in human, mouse, rat TNKS2
     QuantiFast Probe-based Assays in human, mouse, rat TNKS2 QuantiTect SYBR Green Assays in human, mouse, rat TNKS2
     PCR Arrays including human, mouse, rat TNKS2 Search Chromatin IP Primers for TNKS2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNKS2  GeneGlobe Interaction Network for TNKS2
     Regulatory tfbs in TNKS2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TNKS2 GenScript cDNA clones with any tag delivered in your preferred vector for TNKS2
     GenScript Custom Assay Services for TNKS2 GenScript Custom overexpressing Cell Line Services for TNKS2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for TNKS2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TNKS2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TNKS2 antibodies
     TNKS2 proteins
     Antibodies for TNKS2
     See all of Abcam's Antibodies, Kits and Proteins for TNKS2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TNKS2
     Antibodies for TNKS2
     ELISAs for TNKS2
     CLIAs for TNKS2



     Browse ESI BIO Cell Lines and PureStem Progenitors for TNKS2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNKS2
     SwitchGear 3'UTR luciferase reporter plasmids for TNKS2
     SwitchGear Promoter luciferase reporter plasmids for TNKS2
     ThermoFisher Antibodies for TNKS2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNKS2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNKS2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNKS2
     LSBio Antibodies in human, mouse, rat for TNKS2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TNKS2 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4