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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNKS2 Gene

protein-coding   GIFtS: 60
GCID: GC10P093548

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase...
 Explore 19 diseases affiliated with
TNKS2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TNKS2    

Aliases
for TNKS2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 21 2     Tankyrase-Like Protein2 3
PARP5B1 2 3     Tankyrase-Related Protein2 3
TANK21 2 3     ARTD62 3
TNKL1 2 3     TNKS-22 3
PARP-5b1 2     ADP-Ribosyltransferase Diphtheria Toxin-Like 62 3
PARP-5c1 2     TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 22 3
PARP5C1 2     Tankyrase 22
PART61     Tankyrase-21
Poly [ADP-Ribose] Polymerase 5B2 3     EC 2.4.2.303
Tankyrase II2 3     

External Ids:    HGNC: 156771   Entrez Gene: 803512   Ensembl: ENSG000001078547   OMIM: 6071285   UniProtKB: Q9H2K23   

Export aliases for TNKS2 gene to outside databases

Previous GC identifers: GC10P092439 GC10P092779 GC10P093689 GC10P093222 GC10P087186


Summaries
for TNKS2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TNKS2_HUMAN, Q9H2K2
Function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and
vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and
AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized
by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of
BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of
TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate
the subcellular distribution of SLC2A4/GLUT4-vesicles

summary for TNKS2:
Tankyrases 1 and 2 (TNKS1/PARP5A and TNKS2/PARP5B/PARP5C) are proteins with poly(ADP-ribose) polymerase
activity. Human tankyrases post-translationally modify multiple proteins involved in processes including
maintenance of telomere length, sister telomere association, insulin responsiveness, spindle assembly and
trafficking of glut4-containing vesicles. Recently tankyrases have been shown be involved in the wnt
signaling pathway. Tankyrases bind directly to axin, a member of the 'destruction complex' involved in
beta-catenin degradation. Inhibition of tankyrase stabilizes axin, increases the activity of the destruction
complex and promotes degradation of beta-catenin. Tankyrases are therefore an attractive target anticancer
therapies.

Gene Wiki entry for TNKS2


Genomic Views
for TNKS2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNKS2 gene promoter:
         AhR   STAT1   Pax-5   STAT3   STAT1beta   Meis-1a   TGIF   Meis-1   Meis-1b   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNKS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNKS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNKS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.3   Ensembl cytogenetic band:  10q23.32   HGNC cytogenetic band: 10q23.3

TNKS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNKS2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P093548:  view genomic region     (about GC identifiers)

Start:
 93,558,069 bp from pter      End:
 93,625,232 bp from pter
Size:
 67,164 bases      Orientation:
 plus strand

Proteins
for TNKS2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TNKS2_HUMAN, Q9H2K2 (See protein sequence)
Recommended Name: Tankyrase-2  
Size: 1166 amino acids; 126918 Da
Subunit: Oligomerizes and associates with TNKS. Interacts with the cytoplasmic domain of LNPEP/Otase in
SLC2A4/GLUT4-vesicles. Binds to the N-terminus of Grb14 and TRF1 with its ankyrin repeat region. Interacts with
HIF1AN. Interacts with RNF146; this interaction leads to ubiquitination and proteasomal degradation
Subcellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome, telomere
(Potential). Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the
pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus,
associated with TRF1
Sequence caution: Sequence=AAG25674.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB14665.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
6/31 PDB 3D structures from and Proteopedia for TNKS2 (see all 31):
2Y0I (3D)        3KR7 (3D)        3KR8 (3D)        3MHJ (3D)        3MHK (3D)        3P0N (3D)    
Secondary accessions: B2RBD3 Q9H8F2 Q9HAS4

Explore the universe of human proteins at neXtProt for TNKS2: NX_Q9H2K2

Post-translational modifications:

  • Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated; this leads to degradation1
  • ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination1
  • The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H2K2

    • TNKS2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079511.1  
    ENSEMBL proteins: 
     ENSP00000360689  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TNKS2

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0000242pericentriolar material IDA11454873
    GO:0000784nuclear chromosome, telomeric region IC11739745
    GO:0005634nucleus IDA11739745
    GO:0005635nuclear envelope IDA11454873


    TNKS2 for ontologies           About GeneDecksing



    TNKS2 Antibody Products: 
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    Uscn Antibodies for TNKS2
    ThermoFisher Antibodies for TNKS2

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    Uscn ELISAs and CLIAs for TNKS2

    Protein Domains /
    Families
    for TNKS2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TNKS2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR011510 SAM_2
     IPR020683 Ankyrin_rpt-contain_dom
     IPR012317 Poly(ADP-ribose)pol_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9H2K2

    ProtoNet protein and cluster: Q9H2K2

    2 Blocks protein families:
    IPB001660 Sterile alpha motif SAM
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: TNKS2_HUMAN, Q9H2K2
    Similarity: Contains 15 ANK repeats
    Similarity: Contains 1 PARP catalytic domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Function
    for TNKS2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TNKS2_HUMAN, Q9H2K2
    Function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and
    vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and
    AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized
    by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of
    BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of
    TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate
    the subcellular distribution of SLC2A4/GLUT4-vesicles
    Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
    Enzyme regulation: Specifically inhibited by XAV939, a small molecule, leading to inhibit the Wnt signaling pathway by
    stabilizing AXIN1 and AXIN2

    Enzyme Number (IUBMB): EC 2.4.2.301

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNKS2
    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate TNKS2 (see all 83):
    hsa-miR-548j hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-520e hsa-miR-106a hsa-miR-200a hsa-miR-374a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: TNKS2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNKS2 (see all 4)
    OriGene shRNA RFP: TNKS2
    OriGene siRNA: TNKS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNKS2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TNKS2

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for TNKS2

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NAD+ ADP-ribosyltransferase activity IDA11739745
    GO:0005515protein binding IPI--
    GO:0019899enzyme binding IPI--
    GO:0046872metal ion binding IEA--


    TNKS2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TNKS2:
     High actin ratio cells 

    Animal Models:
         Mouse knock-outs for TNKS2: Tnks2tm1Susm Tnks2tm1.1Yjc Tnks2tm1.1Susm
         6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tnks2):
     adipose tissue  cardiovascular system  cellular  embryogenesis  growth/size 
     mortality/aging 

    TNKS2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TNKS2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1NAD metabolism
    		NAD metabolism1.00
    		NAD metabolism1.00
    2Telomere Extension by Telomerase
    		Telomere Extension by Telomerase1.00
    3Apoptotic Pathways in Synovial Fibroblasts
    		Telomerase Components in Cell Signaling0.72

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TNKS2
        NAD metabolism

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNKS2
        Telomerase Components in Cell Signaling
    Telomere Extension by Telomerase

    1 GeneGo (Thomson Reuters) Pathway for TNKS2
        NAD metabolism



    TNKS2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNKS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for TNKS2 (Q9H2K21, 2, 3 ENSP000003606894) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIF1ANQ9NWT62, 3, ENSP000002991634MINT-8084814 MINT-8084841 MINT-8084829 MINT-8084940 I2D: score=1 STRING: ENSP00000299163
    TERF1P542741, 3, ENSP000002766034EBI-4398527,EBI-710997 I2D: score=2 STRING: ENSP00000276603
    ZNF512BQ96KM62, 3MINT-60802 I2D: score=2 
    SH3BP2P783141, 3, ENSP000003486854EBI-4398527,EBI-727062 I2D: score=1 STRING: ENSP00000348685
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA--
    GO:0006471protein ADP-ribosylation IDA11739745
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0032212positive regulation of telomere maintenance via telomerase IC11739745
    GO:0035264multicellular organism growth IEA--


    TNKS2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TNKS2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for TNKS2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for TNKS2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    XAV 939Tankyrase inhibitor; inhibits Wnt signaling[284028-89-3]
    JW 55Tankyrase inhibitor; inhibits canonical Wnt signaling[664993-53-7]

    3 HMDB Compounds for TNKS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--
    Search CenterWatch for drugs/clinical trials and news about TNKS2 

    Transcripts
    for TNKS2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TNKS2 gene: 
    NM_025235.3  

    Unigene Cluster for TNKS2:

    Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
    Hs.329327  [show with all ESTs]
    Unigene Representative Sequence: NM_025235
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371627(uc001khp.3)

    miRNA
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    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate TNKS2 (see all 83):
    hsa-miR-548j hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-520e hsa-miR-106a hsa-miR-200a hsa-miR-374a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: TNKS2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF264912.1 AF305081.1 AF309033.1 AF329696.1 AF342982.1 AF438201.1 AK023746.1 AK314612.1 
    AL833676.1 BC023218.1 

    12 DOTS entries:

    DT.442059  DT.97843809  DT.407023  DT.95369691  DT.100000975  DT.100757443  DT.102829799  DT.40212400 
    DT.97767748  DT.121248017  DT.91790763  DT.91938943 

    24/201 AceView cDNA sequences (see all 201):

    AI040839 BP376193 N73890 CA447138 BM464678 AW027833 BX107856 T55578 
    CK429276 BM835034 BU625551 AI381961 AF329696 AW238878 CR595012 AL833676 
    T17118 AF309033 AI444969 BX103336 BU581343 AA307492 AI262121 AA970617 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TNKS2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                                              -                                                               
    SP2:              -                                                                                                               
    SP3:                                                                                                                              
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for TNKS2

    Expression
    for TNKS2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNKS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATAGCTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TNKS2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyCap MesenchymeCap Mesenchyme CellsKidney
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TNKS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNKS2

    SOURCE GeneReport for Unigene cluster: Hs.329327

    UniProtKB/Swiss-Prot: TNKS2_HUMAN, Q9H2K2
    Tissue specificity: Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord,
    lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon,
    mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and
    brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNKS2: 
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    Orthologs
    for TNKS2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TNKS2 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TNKS21 tankyrase, TRF1-interacting ankyrin-related ADP-ribose more 82.93(n)
    94.07(a)    		   374253  NM_204341.1  NP_989672.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TNKS26
    		 --
    		 91(a)
    		 1 ↔ 1
    		 GL343219.1(1111270-1150981)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.143552 Xenopus laevis transcribed sequence with moderate similarity more 74.4(n)    BU904301.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01073736.16
    		 --
    		 9(a)
    		 possible ortholog
    		 19(1535388-1571258)
    fruit fly
    (Drosophila melanogaster)    		 Insecta BcDNA:LD225483
    tankyrase1    		 cytoskeletal anchoring structural
    constituent more3
    CG4719-PA1    		 64(a)3
    60.05(n)1
    67.46(a)1    		   430951  NM_143153.21  NP_651410.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea C29E6.23 ankyrin repeats 23(a)   IV(11865213-11875815)   --


    ENSEMBL Gene Tree for TNKS2 (if available)
    TreeFam Gene Tree for TNKS2 (if available) 

    Paralogs
    for TNKS2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNKS2 gene
    TANC22  ANKRD172  ANK32  ANKHD12  ANK12  ANKRD522  ANKHD1-EIF4EBP32  TNKS2  
    ANKRD502  TANC12  INVS2  ANKRD282  ANK22  ANKRD442  
    4 SIMAP similar genes for TNKS2 using alignment to 1 protein entry:     TNKS2_HUMAN:
    TNKS    CDKN2A    CDKN2B    CDKN2C

    TNKS2 for paralogs           About GeneDecksing



    Genomic Variants
    for TNKS2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1194 NCBI SNPs in TNKS2 are shown (see all 1194)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs797840101,2
    		F,--87186166(+) CTTTTC/TTTTTG 1 -- int11Minor allele frequency- T:0.05NA 120
    rs733259671,2
    		C,F,--87186335(+) ATCAGA/GGCCAT 1 -- nc-transcript-variant3Minor allele frequency- G:0.05WA CSA 122
    rs733259691,2
    		C,--87186607(+) GATCCG/CAGCAA 1 -- nc-transcript-variant2Minor allele frequency- C:0.04WA 120
    rs562265271,2
    		C,--87188011(+) CACATA/GCAAGT 1 -- us2k12Minor allele frequency- G:0.03WA 120
    rs728231281,2
    		C,F,--87188106(+) TCATTC/GTGAAA 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1123749121,2
    		--87188311(+) AATGGG/CAGTAC 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1465680131,2
    		--93556327(+) GGACCC/TCTGTT 2 -- int1 us2k10--------
    rs49332201,2
    		C,F,A,H,--93556497(+) TGAAGG/ACAGTT 2 -- int1 us2k116Minor allele frequency- A:0.30NS EA NA WA CSA 750
    rs1412556671,2
    		C,--93556639(+) TGGAGC/TAGCAC 2 -- int1 us2k10--------
    rs1893408801,2
    		--93556700(+) GGTGCA/CAGGGG 2 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for TNKS2 (93558069 - 93625232 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TNKS2: --

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    Disorders / Diseases
    for TNKS2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TNKS2 for disorders           About GeneDecksing

    OMIM gene information: 607128    OMIM disorders: --

    19 diseases for TNKS2:    About MalaCards
    cherubism    chronic lymphocytic leukemia    lymphocytic leukemia    diphtheria
    cerebrovascular disease    hepatitis b    endometrial cancer    alzheimer's disease
    pancreatic carcinoma    meningioma    breast carcinoma    leukemia
    breast cancer    pancreatitis    hepatitis    carcinoma
    hypoxia    malaria    prostatitis

    2 Novoseek disease relationships for TNKS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0.976 5 16151859 (4), 11294570 (1)
    necrosis 0 1 11454873 (1)

    Human Genome Epidemiology (HuGE) Navigator: TNKS2 (7 documents)

    Export disorders for TNKS2 gene to outside databases

    Publications
    for TNKS2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNKS2 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with TNKS2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. (PubMed id 11454873)1, 2, 9 Kaminker P.G.... Campisi J. (2001)
    2. Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). (PubMed id 11802774)1, 2, 9 Sbodio J.I.... Chi N.-W. (2002)
    3. Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. (PubMed id 11739745)1, 2, 9 Cook B.D.... Smith S. (2002)
    4. Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14. (PubMed id 11278563)1, 2, 9 Lyons R.J.... Daly R.J. (2001)
    5. Cloning and characterization of TNKL, a member of tankyrase gene family. (PubMed id 11294570)1, 2, 9 Kuimov A.N.... Nedospasov S.A. (2001)
    6. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. (PubMed id 19759537)1, 2, 9 Huang S.M....Cong F. (2009)
    7. Novel tankyrase-related gene detected with meningioma-specific sera. (PubMed id 11205898)1, 2, 9 Monz D.... Meese E.U. (2001)
    8. Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling. (PubMed id 21799911)1, 2 Callow M.G....Costa M. (2011)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)

    External Searches for TNKS2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TNKS2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80351 HGNC: 15677 AceView: TNKS2 Ensembl:ENSG00000107854 euGenes: HUgn80351
    ECgene: TNKS2 H-InvDB: TNKS2

    Other Databases showing TNKS2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TNKS2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNKS2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TNKS2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TNKS2 gene:
    Search GeneIP for patents involving TNKS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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