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Aliases for TNKS2 Gene

Aliases for TNKS2 Gene

  • Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 2 3
  • TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 3 4
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 6 3 4
  • Poly [ADP-Ribose] Polymerase 5B 3 4
  • Tankyrase-Related Protein 3 4
  • Tankyrase-Like Protein 3 4
  • Tankyrase II 3 4
  • PARP5B 3 4
  • TNKS-2 3 4
  • ARTD6 3 4
  • TANK2 3 4
  • TNKL 3 4
  • Tankyrase 2 3
  • Tankyrase-2 3
  • EC 2.4.2.30 4
  • PARP-5b 3
  • PARP-5c 3
  • PARP5C 3
  • PART6 3

External Ids for TNKS2 Gene

Summaries for TNKS2 Gene

GeneCards Summary for TNKS2 Gene

TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2) is a Protein Coding gene. Diseases associated with TNKS2 include cherubism. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Nicotinate and nicotinamide metabolism. GO annotations related to this gene include enzyme binding and NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is ANKRD52.

UniProtKB/Swiss-Prot for TNKS2 Gene

  • Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.

Tocris Summary for TNKS2 Gene

  • Tankyrases 1 and 2 (TNKS1/PARP5A and TNKS2/PARP5B/PARP5C) are proteins with poly(ADP-ribose) polymerase activity. Human tankyrases post-translationally modify multiple proteins involved in processes including maintenance of telomere length, sister telomere association, insulin responsiveness, spindle assembly and trafficking of glut4-containing vesicles. Recently tankyrases have been shown be involved in the wnt signaling pathway. Tankyrases bind directly to axin, a member of the destruction complex involved in beta-catenin degradation. Inhibition of tankyrase stabilizes axin, increases the activity of the destruction complex and promotes degradation of beta-catenin. Tankyrases are therefore an attractive target anticancer therapies.

Gene Wiki entry for TNKS2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNKS2 Gene

Genomics for TNKS2 Gene

Genomic Location for TNKS2 Gene

Start:
91,798,312 bp from pter
End:
91,865,475 bp from pter
Size:
67,164 bases
Orientation:
Plus strand

Genomic View for TNKS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNKS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNKS2 Gene

Regulatory Elements for TNKS2 Gene

Proteins for TNKS2 Gene

  • Protein details for TNKS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2K2-TNKS2_HUMAN
    Recommended name:
    Tankyrase-2
    Protein Accession:
    Q9H2K2
    Secondary Accessions:
    • B2RBD3
    • Q9H8F2
    • Q9HAS4

    Protein attributes for TNKS2 Gene

    Size:
    1166 amino acids
    Molecular mass:
    126918 Da
    Quaternary structure:
    • Oligomerizes and associates with TNKS. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of Grb14 and TRF1 with its ankyrin repeat region. Interacts with HIF1AN. Interacts with RNF146; this interaction leads to ubiquitination and proteasomal degradation.
    SequenceCaution:
    • Sequence=AAG25674.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14665.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNKS2 Gene

neXtProt entry for TNKS2 Gene

Proteomics data for TNKS2 Gene at MOPED

Post-translational modifications for TNKS2 Gene

  • ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination
  • The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer
  • Ubiquitinated at Lys-48 and Lys-63 by RNF146 when auto-poly-ADP-ribosylated; this leads to degradation
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys225, Lys331, Lys398, Lys425, and Lys510

Other Protein References for TNKS2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TNKS2 Gene

Domains for TNKS2 Gene

Gene Families for TNKS2 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • SAMD :Sterile alpha motif (SAM) domain containing
  • PARP :Poly (ADP-ribose) polymerases

UniProtKB/Swiss-Prot:

TNKS2_HUMAN
Domain:
  • Contains 1 PARP catalytic domain.:
    • Q9H2K2
  • Contains 1 SAM (sterile alpha motif) domain.:
    • Q9H2K2
Similarity:
  • Contains 15 ANK repeats.:
    • Q9H2K2
genes like me logo Genes that share domains with TNKS2: view

Function for TNKS2 Gene

Molecular function for TNKS2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot EnzymeRegulation: Specifically inhibited by XAV939, a small molecule, leading to inhibit the Wnt signaling pathway by stabilizing AXIN1 and AXIN2.
UniProtKB/Swiss-Prot Function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.

Enzyme Numbers (IUBMB) for TNKS2 Gene

Gene Ontology (GO) - Molecular Function for TNKS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity TAS --
GO:0005515 protein binding IPI 19759537
GO:0019899 enzyme binding IPI 21251231
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TNKS2: view
genes like me logo Genes that share phenotypes with TNKS2: view

Animal Models for TNKS2 Gene

MGI Knock Outs for TNKS2:

No data available for Transcription Factor Targeting and HOMER Transcription for TNKS2 Gene

Localization for TNKS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNKS2 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome, telomere. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNKS2 Gene COMPARTMENTS Subcellular localization image for TNKS2 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytoskeleton 4
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TNKS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0000242 pericentriolar material IDA 11454873
GO:0000784 nuclear chromosome, telomeric region IC 11739745
GO:0005634 nucleus IDA 11739745
GO:0005635 nuclear envelope IDA 11454873
genes like me logo Genes that share ontologies with TNKS2: view

Pathways for TNKS2 Gene

genes like me logo Genes that share pathways with TNKS2: view

Pathways by source for TNKS2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for TNKS2 Gene

Gene Ontology (GO) - Biological Process for TNKS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 19759537
GO:0006471 protein ADP-ribosylation IDA 11739745
GO:0016055 Wnt signaling pathway IEA --
GO:0032212 positive regulation of telomere maintenance via telomerase IC 11739745
GO:0035264 multicellular organism growth IEA --
genes like me logo Genes that share ontologies with TNKS2: view

Compounds for TNKS2 Gene

(5) Tocris Compounds for TNKS2 Gene

Compound Action Cas Number
JW 55 Tankyrase inhibitor; inhibits canonical Wnt signaling [664993-53-7]
NU 1025 Potent PARP inhibitor [90417-38-2]
PJ 34 hydrochloride Potent PARP inhibitor [344458-15-7]
WIKI4 Tankyrase inhibitor; inhibits Wnt signaling [838818-26-1]
XAV 939 Tankyrase inhibitor; inhibits Wnt signaling [284028-89-3]

(3) HMDB Compounds for TNKS2 Gene

Compound Synonyms Cas Number PubMed IDs
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
Niacinamide
  • 3-Carbamoylpyridine
98-92-0
genes like me logo Genes that share compounds with TNKS2: view

Transcripts for TNKS2 Gene

mRNA/cDNA for TNKS2 Gene

Unigene Clusters for TNKS2 Gene

Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNKS2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for TNKS2 Gene

GeneLoc Exon Structure for
TNKS2
ECgene alternative splicing isoforms for
TNKS2

Expression for TNKS2 Gene

mRNA expression in normal human tissues for TNKS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNKS2 Gene

SOURCE GeneReport for Unigene cluster for TNKS2 Gene Hs.329327

mRNA Expression by UniProt/SwissProt for TNKS2 Gene

Q9H2K2-TNKS2_HUMAN
Tissue specificity: Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain
genes like me logo Genes that share expressions with TNKS2: view

Orthologs for TNKS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TNKS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNKS2 36
  • 99.86 (n)
  • 100 (a)
TNKS2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNKS2 36
  • 92.22 (n)
  • 98.04 (a)
TNKS2 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNKS2 36
  • 94.54 (n)
  • 99.23 (a)
TNKS2 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnks2 36
  • 90.69 (n)
  • 97.37 (a)
Tnks2 16
Tnks2 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNKS2 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNKS2 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910717 36
  • 90.28 (n)
  • 97.45 (a)
chicken
(Gallus gallus)
Aves TNKS2 36
  • 83.23 (n)
  • 94.56 (a)
TNKS2 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNKS2 37
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14355 36
tropical clawed frog
(Silurana tropicalis)
Amphibia tnks2 36
  • 78.36 (n)
  • 90.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta tankyrase 37
  • 64 (a)
OneToMany
BcDNA:LD22548 38
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea C29E6.2 38
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 39
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2238 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 72 (a)
OneToMany
Species with no ortholog for TNKS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TNKS2 Gene

ENSEMBL:
Gene Tree for TNKS2 (if available)
TreeFam:
Gene Tree for TNKS2 (if available)

Paralogs for TNKS2 Gene

Paralogs for TNKS2 Gene

Selected SIMAP similar genes for TNKS2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNKS2: view

Variants for TNKS2 Gene

Sequence variations from dbSNP and Humsavar for TNKS2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs946896 -- 91,843,713(-) AGTCC(A/G)CTGTG intron-variant
rs1340420 -- 91,857,549(+) CCACC(A/G)ACTCT intron-variant
rs1417254 -- 91,846,555(+) TGCCT(C/T)TCTTG intron-variant
rs1417730 -- 91,818,948(+) ATGAC(C/G)CAAGA intron-variant
rs1538831 -- 91,848,278(+) GTACT(A/G)GCACA intron-variant

Relevant External Links for TNKS2 Gene

HapMap Linkage Disequilibrium report
TNKS2

No data available for Structural Variations from Database of Genomic Variants (DGV) for TNKS2 Gene

Disorders for TNKS2 Gene

(1) MalaCards Diseases for TNKS2 Gene

Search for TNKS2 Gene in MalaCards »

(2) Novoseek inferred disease relationships for TNKS2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0.976 5
necrosis 0 1

Relevant External Links for TNKS2

Genetic Association Database (GAD)
TNKS2
Human Genome Epidemiology (HuGE) Navigator
TNKS2
genes like me logo Genes that share disorders with TNKS2: view

No data available for UniProtKB/Swiss-Prot for TNKS2 Gene

Publications for TNKS2 Gene

  1. Novel tankyrase-related gene detected with meningioma-specific sera. (PMID: 11205898) Monz D. … Meese E.U. (Clin. Cancer Res. 2001) 3 4 23
  2. Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14. (PMID: 11278563) Lyons R.J. … Daly R.J. (J. Biol. Chem. 2001) 3 4 23
  3. Cloning and characterization of TNKL, a member of tankyrase gene family. (PMID: 11294570) Kuimov A.N. … Nedospasov S.A. (Genes Immun. 2001) 3 4 23
  4. TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. (PMID: 11454873) Kaminker P.G. … Campisi J. (J. Biol. Chem. 2001) 3 4 23
  5. Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. (PMID: 11739745) Cook B.D. … Smith S. (Mol. Cell. Biol. 2002) 3 4 23

Products for TNKS2 Gene

  • Addgene plasmids for TNKS2

Sources for TNKS2 Gene

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