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Aliases for TNKS1BP1 Gene

Aliases for TNKS1BP1 Gene

  • Tankyrase 1 Binding Protein 1 2 3 5
  • Tankyrase 1 Binding Protein 1, 182kDa 2 3
  • TAB182 3 4
  • Testis Secretory Sperm-Binding Protein Li 206a 3
  • Tankyrase 1-Binding Protein Of 182 KDa 3
  • 182 KDa Tankyrase-1-Binding Protein 3
  • KIAA1741 4

External Ids for TNKS1BP1 Gene

Previous GeneCards Identifiers for TNKS1BP1 Gene

  • GC11M059460
  • GC11M058580
  • GC11M056842
  • GC11M056823
  • GC11M057067
  • GC11M053415

Summaries for TNKS1BP1 Gene

GeneCards Summary for TNKS1BP1 Gene

TNKS1BP1 (Tankyrase 1 Binding Protein 1) is a Protein Coding gene. Among its related pathways are TP53 Regulates Transcription of Cell Cycle Genes and Deadenylation-dependent mRNA decay. GO annotations related to this gene include enzyme binding and ankyrin binding.

Gene Wiki entry for TNKS1BP1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNKS1BP1 Gene

Genomics for TNKS1BP1 Gene

Regulatory Elements for TNKS1BP1 Gene

Enhancers for TNKS1BP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F057740 1.2 ENCODE 29.9 -416.9 -416938 2.7 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 TNKS1BP1 SSRP1 CTNND1 RPS4XP13 OR5AZ1P OR9Q2 OR5B15P OR5B1P OR5B21 MED19
GH11F057973 1.2 ENCODE 29.8 -649.2 -649164 0.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TNKS1BP1 SSRP1 CTNND1 OR5AZ1P OR9Q2 RPS4XP13 OR5B1P OR5B15P OR5B21 BTBD18
GH11F057334 1.3 FANTOM5 ENCODE 26.6 -10.6 -10644 2.7 ATF1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ETS1 TNKS1BP1 SSRP1 CTNND1 LRRC55 P2RX3 ENSG00000254662
GH11F057291 1.1 Ensembl ENCODE 22.3 +30.5 30513 4.9 TAL1 ZFP64 ZIC2 YY1 ZNF121 ZFHX2 ZNF600 NR2F6 ZBTB20 TCF7L2 TNKS1BP1 SSRP1 ENSG00000254662 P2RX3 APLNR MED19 GC11P057311
GH11F057656 1.2 ENCODE 17.7 -332.7 -332685 2.0 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 CLP1 TNKS1BP1 CTNND1 SLC43A1 MED19 YPEL4 ZDHHC5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNKS1BP1 on UCSC Golden Path with GeneCards custom track

Promoters for TNKS1BP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000186720 352 2001 ATF1 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1
ENSR00001768691 1852 201 BCOR ZMYM3 ZNF664 POLR2A ZNF341 KDM1A PRDM10 ZBTB20

Genomic Location for TNKS1BP1 Gene

Chromosome:
11
Start:
57,299,629 bp from pter
End:
57,324,952 bp from pter
Size:
25,324 bases
Orientation:
Minus strand

Genomic View for TNKS1BP1 Gene

Genes around TNKS1BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNKS1BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNKS1BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNKS1BP1 Gene

Proteins for TNKS1BP1 Gene

  • Protein details for TNKS1BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0C2-TB182_HUMAN
    Recommended name:
    182 kDa tankyrase-1-binding protein
    Protein Accession:
    Q9C0C2
    Secondary Accessions:
    • A7E2F8
    • Q6PJ35
    • Q6ZV74

    Protein attributes for TNKS1BP1 Gene

    Size:
    1729 amino acids
    Molecular mass:
    181796 Da
    Quaternary structure:
    • Binds to the ANK repeat domain of TNKS1 and TNKS2.
    SequenceCaution:
    • Sequence=BAB21832.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB84939.1; Type=Frameshift; Positions=1070, 1098, 1466; Evidence={ECO:0000305}; Sequence=BAB84939.1; Type=Frameshift; Positions=1071, 1097, 1467; Evidence={ECO:0000305};

    Alternative splice isoforms for TNKS1BP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNKS1BP1 Gene

Post-translational modifications for TNKS1BP1 Gene

Other Protein References for TNKS1BP1 Gene

No data available for DME Specific Peptides for TNKS1BP1 Gene

Domains & Families for TNKS1BP1 Gene

Protein Domains for TNKS1BP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNKS1BP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNKS1BP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TNKS1BP1 Gene

Function for TNKS1BP1 Gene

Gene Ontology (GO) - Molecular Function for TNKS1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding NAS 11854288
GO:0030506 ankyrin binding NAS 11854288
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with TNKS1BP1: view
genes like me logo Genes that share phenotypes with TNKS1BP1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNKS1BP1 Gene

Localization for TNKS1BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNKS1BP1 Gene

Nucleus. Cytoplasm, cytoskeleton. Chromosome. Note=Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNKS1BP1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for TNKS1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 11854288
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005724 nuclear telomeric heterochromatin NAS 11854288
GO:0005737 cytoplasm NAS 11854288
genes like me logo Genes that share ontologies with TNKS1BP1: view

Pathways & Interactions for TNKS1BP1 Gene

genes like me logo Genes that share pathways with TNKS1BP1: view

Gene Ontology (GO) - Biological Process for TNKS1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
GO:0007004 telomere maintenance via telomerase NAS 11854288
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with TNKS1BP1: view

No data available for SIGNOR curated interactions for TNKS1BP1 Gene

Transcripts for TNKS1BP1 Gene

Unigene Clusters for TNKS1BP1 Gene

Tankyrase 1 binding protein 1, 182kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNKS1BP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - -
SP3:
SP4: - -
SP5: -

Relevant External Links for TNKS1BP1 Gene

GeneLoc Exon Structure for
TNKS1BP1
ECgene alternative splicing isoforms for
TNKS1BP1

Expression for TNKS1BP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNKS1BP1 Gene

Protein differential expression in normal tissues from HIPED for TNKS1BP1 Gene

This gene is overexpressed in Cervix (15.9) and Pancreas (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNKS1BP1 Gene



Protein tissue co-expression partners for TNKS1BP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNKS1BP1 Gene:

TNKS1BP1

SOURCE GeneReport for Unigene cluster for TNKS1BP1 Gene:

Hs.530730

mRNA Expression by UniProt/SwissProt for TNKS1BP1 Gene:

Q9C0C2-TB182_HUMAN
Tissue specificity: Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very low levels in brain and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with TNKS1BP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TNKS1BP1 Gene

Orthologs for TNKS1BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNKS1BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNKS1BP1 34 35
  • 97.98 (n)
dog
(Canis familiaris)
Mammalia TNKS1BP1 34 35
  • 83.01 (n)
mouse
(Mus musculus)
Mammalia Tnks1bp1 34 16 35
  • 77.51 (n)
rat
(Rattus norvegicus)
Mammalia Tnks1bp1 34
  • 77.5 (n)
cow
(Bos Taurus)
Mammalia TNKS1BP1 34 35
  • 73.32 (n)
oppossum
(Monodelphis domestica)
Mammalia TNKS1BP1 35
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNKS1BP1 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNKS1BP1 35
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNKS1BP1 35
  • 29 (a)
OneToOne
Species where no ortholog for TNKS1BP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNKS1BP1 Gene

ENSEMBL:
Gene Tree for TNKS1BP1 (if available)
TreeFam:
Gene Tree for TNKS1BP1 (if available)

Paralogs for TNKS1BP1 Gene

No data available for Paralogs for TNKS1BP1 Gene

Variants for TNKS1BP1 Gene

Sequence variations from dbSNP and Humsavar for TNKS1BP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1044294 -- 57,299,910(-) CCCCA(A/C)ACCTT utr-variant-3-prime
rs1050660 -- 57,326,199(-) GGGGA(A/G)AGATA upstream-variant-2KB, utr-variant-3-prime
rs10792085 -- 57,310,800(+) AAGCA(C/T)TCAGC intron-variant
rs10792086 -- 57,315,422(+) CATCA(C/T)ACTGT intron-variant
rs10896601 -- 57,307,918(+) CAAGT(A/C)CCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNKS1BP1 Gene

Variant ID Type Subtype PubMed ID
esv3547831 CNV deletion 23714750
nsv1070036 CNV deletion 25765185

Variation tolerance for TNKS1BP1 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.64; 82.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNKS1BP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNKS1BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNKS1BP1 Gene

Disorders for TNKS1BP1 Gene

Relevant External Links for TNKS1BP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNKS1BP1

No disorders were found for TNKS1BP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNKS1BP1 Gene

Publications for TNKS1BP1 Gene

  1. The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). (PMID: 11854288) Seimiya H. … Smith S. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H. … Ohara O. (DNA Res. 2003) 3 4 64
  5. Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner. (PMID: 12080061) Sbodio J.I. … Chi N.W. (J. Biol. Chem. 2002) 3 22 64

Products for TNKS1BP1 Gene

Sources for TNKS1BP1 Gene

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