Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TNKS1BP1 Gene

Aliases for TNKS1BP1 Gene

  • Tankyrase 1 Binding Protein 1 2 3 5
  • Tankyrase 1 Binding Protein 1, 182kDa 2 3
  • TAB182 3 4
  • Testis Secretory Sperm-Binding Protein Li 206a 3
  • Tankyrase 1-Binding Protein Of 182 KDa 3
  • KIAA1741 4

External Ids for TNKS1BP1 Gene

Previous GeneCards Identifiers for TNKS1BP1 Gene

  • GC11M059460
  • GC11M058580
  • GC11M056842
  • GC11M056823
  • GC11M057067
  • GC11M053415

Summaries for TNKS1BP1 Gene

GeneCards Summary for TNKS1BP1 Gene

TNKS1BP1 (Tankyrase 1 Binding Protein 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of TP53 Activity. GO annotations related to this gene include enzyme binding and ankyrin binding.

Gene Wiki entry for TNKS1BP1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNKS1BP1 Gene

Genomics for TNKS1BP1 Gene

Regulatory Elements for TNKS1BP1 Gene

Promoters for TNKS1BP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNKS1BP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNKS1BP1 Gene

Chromosome:
11
Start:
57,299,629 bp from pter
End:
57,324,952 bp from pter
Size:
25,324 bases
Orientation:
Minus strand

Genomic View for TNKS1BP1 Gene

Genes around TNKS1BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNKS1BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNKS1BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNKS1BP1 Gene

Proteins for TNKS1BP1 Gene

  • Protein details for TNKS1BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0C2-TB182_HUMAN
    Recommended name:
    182 kDa tankyrase-1-binding protein
    Protein Accession:
    Q9C0C2
    Secondary Accessions:
    • A7E2F8
    • Q6PJ35
    • Q6ZV74

    Protein attributes for TNKS1BP1 Gene

    Size:
    1729 amino acids
    Molecular mass:
    181796 Da
    Quaternary structure:
    • Binds to the ANK repeat domain of TNKS1 and TNKS2.
    SequenceCaution:
    • Sequence=BAB21832.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB84939.1; Type=Frameshift; Positions=1070, 1098, 1466; Evidence={ECO:0000305}; Sequence=BAB84939.1; Type=Frameshift; Positions=1071, 1097, 1467; Evidence={ECO:0000305};

    Alternative splice isoforms for TNKS1BP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNKS1BP1 Gene

Proteomics data for TNKS1BP1 Gene at MOPED

Post-translational modifications for TNKS1BP1 Gene

Other Protein References for TNKS1BP1 Gene

Antibody Products

No data available for DME Specific Peptides for TNKS1BP1 Gene

Domains & Families for TNKS1BP1 Gene

Protein Domains for TNKS1BP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNKS1BP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNKS1BP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TNKS1BP1 Gene

Function for TNKS1BP1 Gene

genes like me logo Genes that share phenotypes with TNKS1BP1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNKS1BP1 Gene

Localization for TNKS1BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNKS1BP1 Gene

Nucleus. Cytoplasm, cytoskeleton. Chromosome. Note=Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNKS1BP1 Gene COMPARTMENTS Subcellular localization image for TNKS1BP1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
plasma membrane 5
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for TNKS1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm NAS 11854288
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with TNKS1BP1: view

Pathways & Interactions for TNKS1BP1 Gene

genes like me logo Genes that share pathways with TNKS1BP1: view

Gene Ontology (GO) - Biological Process for TNKS1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with TNKS1BP1: view

No data available for SIGNOR curated interactions for TNKS1BP1 Gene

Drugs & Compounds for TNKS1BP1 Gene

No Compound Related Data Available

Transcripts for TNKS1BP1 Gene

Unigene Clusters for TNKS1BP1 Gene

Tankyrase 1 binding protein 1, 182kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNKS1BP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - -
SP3:
SP4: - -
SP5: -

Relevant External Links for TNKS1BP1 Gene

GeneLoc Exon Structure for
TNKS1BP1
ECgene alternative splicing isoforms for
TNKS1BP1

Expression for TNKS1BP1 Gene

mRNA expression in normal human tissues for TNKS1BP1 Gene

Protein differential expression in normal tissues from HIPED for TNKS1BP1 Gene

This gene is overexpressed in Cervix (15.9) and Pancreas (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNKS1BP1 Gene



SOURCE GeneReport for Unigene cluster for TNKS1BP1 Gene Hs.530730

mRNA Expression by UniProt/SwissProt for TNKS1BP1 Gene

Q9C0C2-TB182_HUMAN
Tissue specificity: Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very low levels in brain and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with TNKS1BP1: view

Protein tissue co-expression partners for TNKS1BP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TNKS1BP1 Gene

Orthologs for TNKS1BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNKS1BP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TNKS1BP1 35
  • 73.32 (n)
  • 65.07 (a)
TNKS1BP1 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNKS1BP1 35
  • 83.01 (n)
  • 77.05 (a)
TNKS1BP1 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnks1bp1 35
  • 77.51 (n)
  • 71.17 (a)
Tnks1bp1 16
Tnks1bp1 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNKS1BP1 35
  • 97.98 (n)
  • 97.11 (a)
TNKS1BP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnks1bp1 35
  • 77.5 (n)
  • 71.3 (a)
oppossum
(Monodelphis domestica)
Mammalia TNKS1BP1 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNKS1BP1 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNKS1BP1 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNKS1BP1 36
  • 29 (a)
OneToOne
Species with no ortholog for TNKS1BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNKS1BP1 Gene

ENSEMBL:
Gene Tree for TNKS1BP1 (if available)
TreeFam:
Gene Tree for TNKS1BP1 (if available)

Paralogs for TNKS1BP1 Gene

No data available for Paralogs for TNKS1BP1 Gene

Variants for TNKS1BP1 Gene

Sequence variations from dbSNP and Humsavar for TNKS1BP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs4939134 - 57,313,723(+) CAGGA(C/G)TCTGG reference, missense
rs34203865 - 57,312,547(+) AGGTA(C/T)TTGGG upstream-variant-2KB, reference, missense
rs1044294 -- 57,299,910(+) CCCCA(A/C/G/T)ACCTT utr-variant-3-prime
rs3935068 -- 57,311,247(-) CTCCC(A/G)CCCAC intron-variant, reference, synonymous-codon
rs3935069 -- 57,311,480(-) GGTGA(A/G)GGAGA intron-variant, upstream-variant-2KB

Variation tolerance for TNKS1BP1 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.64; 82.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNKS1BP1 Gene

HapMap Linkage Disequilibrium report
TNKS1BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TNKS1BP1 Gene

Disorders for TNKS1BP1 Gene

Relevant External Links for TNKS1BP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNKS1BP1

No disorders were found for TNKS1BP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNKS1BP1 Gene

Publications for TNKS1BP1 Gene

  1. The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). (PMID: 11854288) Seimiya H. … Smith S. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner. (PMID: 12080061) Sbodio J.I. … Chi N.W. (J. Biol. Chem. 2002) 3 23
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for TNKS1BP1 Gene

Sources for TNKS1BP1 Gene

Back to Top

Content