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TNKS1BP1 Gene

protein-coding   GIFtS: 53
GCID: GC11M057067

Tankyrase 1 Binding Protein 1, 182kDa

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tankyrase 1 Binding Protein 1, 182kDa1 2
TAB1822 3 5
KIAA17413 5
182 KDa Tankyrase-1-Binding Protein2
Tankyrase 1-Binding Protein Of 182 KDa2

External Ids:    HGNC: 190811   Entrez Gene: 854562   Ensembl: ENSG000001491157   OMIM: 6071045   UniProtKB: Q9C0C23   

Export aliases for TNKS1BP1 gene to outside databases

Previous GC identifers: GC11M059460 GC11M058580 GC11M057318 GC11M056842 GC11M056823 GC11M053415


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TNKS1BP1 Gene:
TNKS1BP1 (tankyrase 1 binding protein 1, 182kDa) is a protein-coding gene. Diseases associated with TNKS1BP1 include prostatitis, and prostate cancer. GO annotations related to this gene include ankyrin binding and enzyme binding.

Gene Wiki entry for TNKS1BP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNKS1BP1 gene promoter:
         Pax-5   Lmo2   GATA-1   Egr-4   E47   PPAR-gamma1   HFH-1   Hand1   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNKS1BP1 promoter sequence
   Search Chromatin IP Primers for TNKS1BP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNKS1BP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.2

TNKS1BP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNKS1BP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057067:  view genomic region     (about GC identifiers)

Start:
57,067,103 bp from pter      End:
57,092,426 bp from pter
Size:
25,324 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TB182_HUMAN, Q9C0C2 (See protein sequence)
Recommended Name: 182 kDa tankyrase-1-binding protein  
Size: 1729 amino acids; 181796 Da
Subunit: Binds to the ANK repeat domain of TNKS1 and TNKS2
Sequence caution: Sequence=BAB21832.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB84939.1; Type=Frameshift; Positions=1070, 1098, 1466; Sequence=BAB84939.1; Type=Frameshift;
Positions=1071, 1097, 1467;
Secondary accessions: A7E2F8 Q6PJ35 Q6ZV74
Alternative splicing: 2 isoforms:  Q9C0C2-1   Q9C0C2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNKS1BP1: NX_Q9C0C2

Explore proteomics data for TNKS1BP1 at MOPED

Post-translational modifications: 

  • ADP-ribosylated by TNKS1 (in vitro)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TNKS1BP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_203754.2  
    ENSEMBL proteins: 
     ENSP00000431616   ENSP00000350990   ENSP00000437271   ENSP00000433576  
    Reactome Protein details: Q9C0C2

    TNKS1BP1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9C0C2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019899enzyme binding NAS11854288
    GO:0030506ankyrin binding NAS11854288
         
    TNKS1BP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNKS1BP1:
     Increased gamma-H2AX phosphory  Low eccentricity cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNKS1BP1
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    miRNA
    Products:
        
    miRTarBase miRNAs that target TNKS1BP1:
    hsa-mir-182-5p (MIRT047207), hsa-mir-93-5p (MIRT028048), hsa-mir-18a-3p (MIRT040966), hsa-mir-1 (MIRT023682), hsa-mir-1296-5p (MIRT036104), hsa-mir-155-5p (MIRT020675), hsa-mir-484 (MIRT042235), hsa-mir-130b-3p (MIRT020157), hsa-mir-3157-5p (MIRT052664), hsa-mir-125b-5p (MIRT046043)

    Block miRNA regulation of human, mouse, rat TNKS1BP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNKS1BP1 (see all 30):
    hsa-miR-498 hsa-miR-485-5p hsa-miR-520d-5p hsa-miR-106a hsa-miR-340 hsa-miR-519a hsa-miR-766 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidTNKS1BP1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat TNKS1BP1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNKS1BP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TB182_HUMAN, Q9C0C2: Nucleus. Cytoplasm, cytoskeleton. Chromosome. Note=Colocalizes with chromosomes during
    mitosis, and in the cytoplasm with cortical actin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11854288
    GO:0005724nuclear telomeric heterochromatin NAS11854288
    GO:0005737cytoplasm NAS11854288
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--

    TNKS1BP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNKS1BP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    Deadenylation of mRNA0.48
    2Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TNKS1BP1
        Deadenylation of mRNA



    TNKS1BP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TNKS1BP1
    Interactions:

        GeneGlobe Interaction Network for TNKS1BP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for TNKS1BP1 (Q9C0C22, 3 ENSP000003509904) via UniProtKB, MINT, STRING, and/or I2D (see all 570)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNKSO952713, ENSP000003115794I2D: score=2 STRING: ENSP00000311579
    TNKS2Q9H2K23, ENSP000003606894I2D: score=2 STRING: ENSP00000360689
    TOB1P506163, ENSP000002689574I2D: score=1 STRING: ENSP00000268957
    CNOT10Q9H9A52, ENSP000003300604MINT-7947479 STRING: ENSP00000330060
    CNOT6Q9ULM63, ENSP000002619514I2D: score=1 STRING: ENSP00000261951
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    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0007004telomere maintenance via telomerase NAS11854288
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--

    TNKS1BP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNKS1BP1 (TB182)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TNKS1BP1 gene: 
    NM_033396.2  

    Unigene Cluster for TNKS1BP1:

    Tankyrase 1 binding protein 1, 182kDa
    Hs.530730  [show with all ESTs]
    Unigene Representative Sequence: NM_033396
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528882 ENST00000532273 ENST00000358252(uc001njs.3 uc009ymd.1)
    ENST00000532437(uc001njr.3) ENST00000427750(uc001njq.3) ENST00000530920
    ENST00000527207
    miRNA
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    Block miRNA regulation of human, mouse, rat TNKS1BP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNKS1BP1 (see all 30):
    hsa-miR-498 hsa-miR-485-5p hsa-miR-520d-5p hsa-miR-106a hsa-miR-340 hsa-miR-519a hsa-miR-766 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidTNKS1BP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TNKS1BP1
    Predesigned siRNA for gene silencing in human, mouse, rat TNKS1BP1
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    GenScript: all cDNA clones in your preferred vector: TNKS1BP1 (NM_033396)
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      QuantiTect SYBR Green Assays in human, mouse, rat TNKS1BP1
      QuantiFast Probe-based Assays in human, mouse, rat TNKS1BP1

    Additional mRNA sequence: 

    AB051528.2 AK074113.1 AK124903.1 AK127871.1 BC023622.2 BC046216.1 BC150333.1 

    14 DOTS entries:

    DT.100777456  DT.95085544  DT.115800  DT.100681738  DT.120692640  DT.95138119  DT.100793375  DT.100803459 
    DT.40236428  DT.92046058  DT.92433459  DT.95069228  DT.95123705  DT.95228549 

    Selected AceView cDNA sequences (see all 231):

    BP364158 BX281296 BE046455 BQ631211 BQ712379 CR607285 BC046216 AI453356 
    BM973669 BU538908 W73588 AA564694 BC023622 BQ719303 AK127871 BG819491 
    AK124903 BP357084 CA454281 BM474773 BQ932533 BF846191 CN482566 BF928732 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TNKS1BP1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:        -     -                       -                             -                                       
    SP2:                                      -                             -                                       
    SP3:                                                                                                            
    SP4:        -     -                                                                                             
    SP5:              -                                                                                             


    ECgene alternative splicing isoforms for TNKS1BP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNKS1BP1 expression in normal human tissues (normalized intensities)      TNKS1BP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCAGGCTG
    TNKS1BP1 Expression
    About this image


    TNKS1BP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    TNKS1BP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNKS1BP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530730

    UniProtKB/Swiss-Prot: TB182_HUMAN, Q9C0C2
    Tissue specificity: Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very
    low levels in brain and peripheral blood leukocytes

        Custom PCR Arrays for TNKS1BP1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNKS1BP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNKS1BP1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnks1bp11 , 5 tankyrase 1 binding protein 11, 5 77.51(n)1
    71.17(a)1
      2 (49.45 cM)5
    2281401  NM_001081260.21  NP_001074729.11 
     850480225 
    chicken
    (Gallus gallus)
    Aves TNKS1BP16
    tankyrase 1 binding protein 1, 182kDa
    33(a)
    1 ↔ 1
    5(16342325-16354070) ENSGALG00000027524
    lizard
    (Anolis carolinensis)
    Reptilia TNKS1BP16
    tankyrase 1 binding protein 1, 182kDa
    29(a)
    1 ↔ 1
    1(92168758-92189692)


    ENSEMBL Gene Tree for TNKS1BP1 (if available)
    TreeFam Gene Tree for TNKS1BP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNKS1BP1 (see all 715)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs797531031,2
    F--57066659(+) TAGGCG/ATCTGT 1 -- int11Minor allele frequency- A:0.08WA 118
    rs1178398181,2
    F--57066898(+) CCTTTT/CTGTGT 1 -- int11Minor allele frequency- C:0.01EA 120
    rs1908128421,2
    --57067297(+) GGCTGC/GAGGAG 1 -- ut310--------
    rs1834735581,2
    --57067299(+) CTGGAA/GGAGGA 1 -- ut310--------
    rs10442941,2
    C--57067384(-) CCCCAC/AACCTT 1 -- ut31 ese31Minor allele frequency- A:0.00NA 2
    rs1383456361,2
    --57067397(+) AGTTCA/GGAGGG 1 -- ut310--------
    rs1863771521,2
    --57067436(+) CAGACG/TCTCCT 1 -- ut310--------
    rs1428728091,2
    --57067446(+) TCAGAG/TGTGGA 1 -- ut310--------
    rs1912836441,2
    --57067736(+) ATGGGA/GGGACT 1 -- int10--------
    rs589427811,2
    C--57067782(+) CCCTT-/CTCCTCTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TNKS1BP1 (57067103 - 57092426 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TNKS1BP1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNKS1BP1
    DNA2.0 Custom Variant and Variant Library Synthesis for TNKS1BP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607104    OMIM disorders: --

    2 diseases for TNKS1BP1:    About MalaCards
    prostatitis    prostate cancer


    TNKS1BP1 for disorders           About GeneDecksing


    Export disorders for TNKS1BP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNKS1BP1 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with TNKS1BP1)
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    1. The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). (PubMed id 11854288)1, 2, 3, 9 Seimiya H. and Smith S. (J. Biol. Chem. 2002)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)1, 2 Jikuya H....Ohara O. (DNA Res. 2003)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    6. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    7. Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner. (PubMed id 12080061)1, 9 Sbodio J.I. and Chi N.W. (J. Biol. Chem. 2002)
    8. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    9. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85456 HGNC: 19081 AceView: TNKS1BP1 Ensembl:ENSG00000149115 euGenes: HUgn85456
    ECgene: TNKS1BP1 H-InvDB: TNKS1BP1

    (According to HUGE)
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    HUGE: KIAA1741

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNKS1BP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNKS1BP1 gene:
    Search GeneIP for patents involving TNKS1BP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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