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Aliases for TNKS1BP1 Gene

Aliases for TNKS1BP1 Gene

  • Tankyrase 1 Binding Protein 1, 182kDa 2 3
  • TAB182 3 4 6
  • KIAA1741 4 6
  • Tankyrase 1-Binding Protein Of 182 KDa 3
  • 182 KDa Tankyrase-1-Binding Protein 3

External Ids for TNKS1BP1 Gene

Previous GeneCards Identifiers for TNKS1BP1 Gene

  • GC11M059460
  • GC11M058580
  • GC11M056842
  • GC11M056823
  • GC11M057067
  • GC11M053415

Summaries for TNKS1BP1 Gene

GeneCards Summary for TNKS1BP1 Gene

TNKS1BP1 (Tankyrase 1 Binding Protein 1, 182kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. GO annotations related to this gene include enzyme binding and ankyrin binding.

Gene Wiki entry for TNKS1BP1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNKS1BP1 Gene

Genomics for TNKS1BP1 Gene

Regulatory Elements for TNKS1BP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNKS1BP1 Gene

57,299,629 bp from pter
57,325,011 bp from pter
25,383 bases
Minus strand

Genomic View for TNKS1BP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNKS1BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNKS1BP1 Gene

Proteins for TNKS1BP1 Gene

  • Protein details for TNKS1BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    182 kDa tankyrase-1-binding protein
    Protein Accession:
    Secondary Accessions:
    • A7E2F8
    • Q6PJ35
    • Q6ZV74

    Protein attributes for TNKS1BP1 Gene

    1729 amino acids
    Molecular mass:
    181796 Da
    Quaternary structure:
    • Binds to the ANK repeat domain of TNKS1 and TNKS2
    • Sequence=BAB21832.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB84939.1; Type=Frameshift; Positions=1070, 1098, 1466; Evidence={ECO:0000305}; Sequence=BAB84939.1; Type=Frameshift; Positions=1071, 1097, 1467; Evidence={ECO:0000305};

    Alternative splice isoforms for TNKS1BP1 Gene


neXtProt entry for TNKS1BP1 Gene

Proteomics data for TNKS1BP1 Gene at MOPED

Post-translational modifications for TNKS1BP1 Gene

Other Protein References for TNKS1BP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TNKS1BP1 Gene

Domains for TNKS1BP1 Gene

Protein Domains for TNKS1BP1 Gene


Suggested Antigen Peptide Sequences for TNKS1BP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNKS1BP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TNKS1BP1 Gene

Function for TNKS1BP1 Gene

Gene Ontology (GO) - Molecular Function for TNKS1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding NAS 11854288
GO:0030506 ankyrin binding NAS 11854288
genes like me logo Genes that share ontologies with TNKS1BP1: view

Phenotypes for TNKS1BP1 Gene

GenomeRNAi human phenotypes for TNKS1BP1:
genes like me logo Genes that share phenotypes with TNKS1BP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNKS1BP1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TNKS1BP1 Gene

Localization for TNKS1BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNKS1BP1 Gene

Nucleus. Cytoplasm, cytoskeleton. Chromosome. Note=Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.

Subcellular locations from

Jensen Localization Image for TNKS1BP1 Gene COMPARTMENTS Subcellular localization image for TNKS1BP1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TNKS1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 11854288
GO:0005654 nucleoplasm IDA --
GO:0005724 nuclear telomeric heterochromatin NAS 11854288
GO:0005737 cytoplasm NAS 11854288
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TNKS1BP1: view

Pathways for TNKS1BP1 Gene

genes like me logo Genes that share pathways with TNKS1BP1: view

Pathways by source for TNKS1BP1 Gene

Gene Ontology (GO) - Biological Process for TNKS1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0007004 telomere maintenance via telomerase NAS 11854288
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process --
genes like me logo Genes that share ontologies with TNKS1BP1: view

Transcripts for TNKS1BP1 Gene

Unigene Clusters for TNKS1BP1 Gene

Tankyrase 1 binding protein 1, 182kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNKS1BP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNKS1BP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - -
SP4: - -
SP5: -

Relevant External Links for TNKS1BP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNKS1BP1 Gene

mRNA expression in normal human tissues for TNKS1BP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TNKS1BP1 Gene

This gene is overexpressed in Cervix (15.9) and Pancreas (10.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNKS1BP1 Gene

SOURCE GeneReport for Unigene cluster for TNKS1BP1 Gene Hs.530730

mRNA Expression by UniProt/SwissProt for TNKS1BP1 Gene

Tissue specificity: Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very low levels in brain and peripheral blood leukocytes
genes like me logo Genes that share expressions with TNKS1BP1: view

Expression partners for TNKS1BP1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TNKS1BP1 Gene

Orthologs for TNKS1BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNKS1BP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNKS1BP1 35
  • 73.32 (n)
  • 65.07 (a)
  • 62 (a)
(Canis familiaris)
Mammalia TNKS1BP1 35
  • 83.01 (n)
  • 77.05 (a)
  • 76 (a)
(Mus musculus)
Mammalia Tnks1bp1 35
  • 77.51 (n)
  • 71.17 (a)
Tnks1bp1 16
Tnks1bp1 36
  • 71 (a)
(Pan troglodytes)
Mammalia TNKS1BP1 35
  • 97.98 (n)
  • 97.11 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tnks1bp1 35
  • 77.5 (n)
  • 71.3 (a)
(Monodelphis domestica)
Mammalia TNKS1BP1 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia TNKS1BP1 36
  • 45 (a)
(Gallus gallus)
Aves TNKS1BP1 36
  • 33 (a)
(Anolis carolinensis)
Reptilia TNKS1BP1 36
  • 29 (a)
Species with no ortholog for TNKS1BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNKS1BP1 Gene

Gene Tree for TNKS1BP1 (if available)
Gene Tree for TNKS1BP1 (if available)

Paralogs for TNKS1BP1 Gene

No data available for Paralogs for TNKS1BP1 Gene

Variants for TNKS1BP1 Gene

Sequence variations from dbSNP and Humsavar for TNKS1BP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1044294 -- 57,299,910(-) CCCCA(A/C)ACCTT utr-variant-3-prime
rs3935068 -- 57,311,247(-) CTCCC(A/G)CCCAC intron-variant, synonymous-codon, reference
rs3935069 -- 57,311,480(-) GGTGA(A/G)GGAGA intron-variant, upstream-variant-2KB
rs4939133 -- 57,311,438(+) TGCTA(C/T)CCGCG intron-variant, utr-variant-5-prime
rs4939134 - 57,313,723(+) CAGGA(C/G)TCTGG reference, missense

Relevant External Links for TNKS1BP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TNKS1BP1 Gene

Disorders for TNKS1BP1 Gene

No disorders were found for TNKS1BP1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TNKS1BP1 Gene

Publications for TNKS1BP1 Gene

  1. The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). (PMID: 11854288) Seimiya H. … Smith S. (J. Biol. Chem. 2002) 2 3 4 23
  2. Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner. (PMID: 12080061) Sbodio J.I. … Chi N.W. (J. Biol. Chem. 2002) 3 23
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  5. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H. … Ohara O. (DNA Res. 2003) 3 4

Products for TNKS1BP1 Gene

Sources for TNKS1BP1 Gene

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