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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNKS1BP1 Gene

protein-coding   GIFtS: 52
GCID: GC11M057067

Tankyrase 1 Binding Protein 1, 182kDa

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tankyrase 1 Binding Protein 1, 182kDa1 2
TAB1822 3 5
KIAA17413 5
182 KDa Tankyrase-1-Binding Protein2
Tankyrase 1-Binding Protein Of 182 KDa2

External Ids:    HGNC: 190811   Entrez Gene: 854562   Ensembl: ENSG000001491157   OMIM: 6071045   UniProtKB: Q9C0C23   

Export aliases for TNKS1BP1 gene to outside databases

Previous GC identifers: GC11M059460 GC11M058580 GC11M057318 GC11M056842 GC11M056823 GC11M053415


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TNKS1BP1 Gene: 
TNKS1BP1 (tankyrase 1 binding protein 1, 182kDa) is a protein-coding gene. Diseases associated with TNKS1BP1 include prostate cancer, and prostatitis, and among its related super-pathways are Metabolism of RNA and Deadenylation-dependent mRNA decay. GO annotations related to this gene include ankyrin binding and enzyme binding.

Gene Wiki entry for TNKS1BP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNKS1BP1 gene promoter:
         Pax-5   Lmo2   GATA-1   Egr-4   E47   PPAR-gamma1   HFH-1   Hand1   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNKS1BP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNKS1BP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNKS1BP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.2

TNKS1BP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNKS1BP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057067:  view genomic region     (about GC identifiers)

Start:
57,067,103 bp from pter      End:
57,092,426 bp from pter
Size:
25,324 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TB182_HUMAN, Q9C0C2 (See protein sequence)
Recommended Name: 182 kDa tankyrase-1-binding protein  
Size: 1729 amino acids; 181796 Da
Subunit: Binds to the ANK repeat domain of TNKS1 and TNKS2
Subcellular location: Nucleus. Cytoplasm, cytoskeleton. Chromosome. Note=Colocalizes with chromosomes during
mitosis, and in the cytoplasm with cortical actin
Sequence caution: Sequence=BAB21832.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB84939.1; Type=Frameshift; Positions=1070, 1098, 1466; Sequence=BAB84939.1; Type=Frameshift;
Positions=1071, 1097, 1467;
Secondary accessions: A7E2F8 Q6PJ35 Q6ZV74
Alternative splicing: 2 isoforms:  Q9C0C2-1   Q9C0C2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNKS1BP1: NX_Q9C0C2

Explore proteomics data for TNKS1BP1 at MOPED 

Post-translational modifications:

  • UniProtKB: ADP-ribosylated by TNKS1 (in vitro)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9C0C2

  • TNKS1BP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNKS1BP1 Protein Expression
    REFSEQ proteins: NP_203754.2  
    ENSEMBL proteins: 
     ENSP00000431616   ENSP00000350990   ENSP00000437271   ENSP00000433576  
    Reactome Protein details: Q9C0C2
    Human Recombinant Protein Products for TNKS1BP1: 
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    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11854288
    GO:0005724nuclear telomeric heterochromatin NAS11854288
    GO:0005737cytoplasm NAS11854288
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--

    TNKS1BP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9C0C2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019899enzyme binding NAS11854288
    GO:0030506ankyrin binding NAS11854288
         
    TNKS1BP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNKS1BP1:
     Increased gamma-H2AX phosphory  Low eccentricity cells 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidTNKS1BP1 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNKS1BP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    2Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.49
    Deadenylation of mRNA0.47
    3Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for TNKS1BP1
        Deadenylation of mRNA
    Deadenylation-dependent mRNA decay
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression



    TNKS1BP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNKS1BP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/570 Interacting proteins for TNKS1BP1 (Q9C0C22, 3 ENSP000003509904) via UniProtKB, MINT, STRING, and/or I2D (see all 570)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNKSO952713, ENSP000003115794I2D: score=2 STRING: ENSP00000311579
    TNKS2Q9H2K23, ENSP000003606894I2D: score=2 STRING: ENSP00000360689
    TOB1P506163, ENSP000002689574I2D: score=1 STRING: ENSP00000268957
    CNOT10Q9H9A52, ENSP000003300604MINT-7947479 STRING: ENSP00000330060
    CNOT6Q9ULM63, ENSP000002619514I2D: score=1 STRING: ENSP00000261951
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0007004telomere maintenance via telomerase NAS11854288
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--

    TNKS1BP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNKS1BP1 (TB182)

    Search CenterWatch for drugs/clinical trials and news about TNKS1BP1 / TB182

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNKS1BP1 gene: 
    NM_033396.2  

    Unigene Cluster for TNKS1BP1:

    Tankyrase 1 binding protein 1, 182kDa
    Hs.530730  [show with all ESTs]
    Unigene Representative Sequence: NM_033396
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528882 ENST00000532273 ENST00000358252(uc001njs.3 uc009ymd.1)
    ENST00000532437(uc001njr.3) ENST00000427750(uc001njq.3) ENST00000530920
    ENST00000527207
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    Additional mRNA sequence: 

    AB051528.2 AK074113.1 AK124903.1 AK127871.1 BC023622.2 BC046216.1 BC150333.1 

    14 DOTS entries:

    DT.100777456  DT.95085544  DT.115800  DT.100681738  DT.120692640  DT.95138119  DT.100793375  DT.100803459 
    DT.40236428  DT.92046058  DT.92433459  DT.95069228  DT.95123705  DT.95228549 

    24/231 AceView cDNA sequences (see all 231):

    BQ932533 BP357084 BQ719303 BF928732 AI417348 BC023622 BU149668 AK124903 
    AB051528 BQ712379 BG819491 BE046455 BM474773 AA564694 W73588 BF846191 
    AA768068 BM973669 CD723394 CA426637 BC046216 BX281296 BU538908 BI771678 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TNKS1BP1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:        -     -                       -                             -                                       
    SP2:                                      -                             -                                       
    SP3:                                                                                                            
    SP4:        -     -                                                                                             
    SP5:              -                                                                                             


    ECgene alternative splicing isoforms for TNKS1BP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNKS1BP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCAGGCTG
    TNKS1BP1 Expression
    About this image


    See TNKS1BP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNKS1BP1

    SOURCE GeneReport for Unigene cluster: Hs.530730

    UniProtKB/Swiss-Prot: TB182_HUMAN, Q9C0C2
    Tissue specificity: Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very
    low levels in brain and peripheral blood leukocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TNKS1BP1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnks1bp11 , 5 tankyrase 1 binding protein 11, 5 77.62(n)1
    71.36(a)1
      2 (49.45 cM)5
    2281401  NM_001081260.21  NP_001074729.11 
     850480225 
    chicken
    (Gallus gallus)
    Aves TNKS1BP11 tankyrase 1 binding protein 1, 182kDa 50.85(n)
    41.95(a)
      423136  XM_421067.3  XP_421067.3 
    lizard
    (Anolis carolinensis)
    Reptilia TNKS1BP16
    Uncharacterized protein
    28(a)
    1 ↔ 1
    1(92168758-92189692)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-138n13.16
    tnks1bp16
    tankyrase 1 binding protein 1
    9(a)
    21(a)
    many ↔ many
    many ↔ many
    8(44682243-44753004)
    5(6411256-6446287)


    ENSEMBL Gene Tree for TNKS1BP1 (if available)
    TreeFam Gene Tree for TNKS1BP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/715 SNPs in TNKS1BP1 are shown (see all 715)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs797531031,2
    F--57066659(+) TAGGCG/ATCTGT 1 -- int11Minor allele frequency- A:0.08WA 118
    rs1178398181,2
    F--57066898(+) CCTTTT/CTGTGT 1 -- int11Minor allele frequency- C:0.01EA 120
    rs1908128421,2
    --57067297(+) GGCTGC/GAGGAG 1 -- ut310--------
    rs1834735581,2
    --57067299(+) CTGGAA/GGAGGA 1 -- ut310--------
    rs10442941,2
    C--57067384(-) CCCCAC/AACCTT 1 -- ut31 ese31Minor allele frequency- A:0.00NA 2
    rs1383456361,2
    --57067397(+) AGTTCA/GGAGGG 1 -- ut310--------
    rs1863771521,2
    --57067436(+) CAGACG/TCTCCT 1 -- ut310--------
    rs1428728091,2
    --57067446(+) TCAGAG/TGTGGA 1 -- ut310--------
    rs1912836441,2
    --57067736(+) ATGGGA/GGGACT 1 -- int10--------
    rs589427811,2
    C--57067782(+) CCCTT-/CTCCTCTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TNKS1BP1 (57067103 - 57092426 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TNKS1BP1: --
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    DNA2.0 Custom Variant and Variant Library Synthesis for TNKS1BP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607104    OMIM disorders: --

    2 diseases for TNKS1BP1:    About MalaCards
    prostate cancer    prostatitis


    TNKS1BP1 for disorders           About GeneDecksing


    Export disorders for TNKS1BP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNKS1BP1 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with TNKS1BP1)
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    1. The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). (PubMed id 11854288)1, 2, 3, 9 Seimiya H. and Smith S. (2002)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)1, 2 Jikuya H....Ohara O. (2003)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    6. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (2000)
    7. Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner. (PubMed id 12080061)1, 9 Sbodio J.I. and Chi N.W. (2002)
    8. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 85456 HGNC: 19081 AceView: TNKS1BP1 Ensembl:ENSG00000149115 euGenes: HUgn85456
    ECgene: TNKS1BP1 H-InvDB: TNKS1BP1

    (According to HUGE)
    About This Section
    HUGE: KIAA1741

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNKS1BP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNKS1BP1 gene:
    Search GeneIP for patents involving TNKS1BP1

    GeneCards and IP:
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