V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

TNKS Gene

protein-coding GIFtS: 62

GC08P009450

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.4.2.30 ^³
OTTHUMP00000115550 ^²
PARP-5a ^¹, ²
PARP5A ^¹, ², ³
PARPL ^², ³
TANK1 ^³
TIN1 ^¹, ², ³
TINF1 ^¹, ², ³
TNKS-1 ^³
TNKS1 ^¹, ², ³

Descriptions
TRF1-interacting ankyrin-related ADP-ribose polymerase ^³
Tankyrase I ^³
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase ^²

External Ids
HGNC: 11941¹
Entrez Gene: 8658²
UniProtKB: O95271³
Ensembl: ENSG00000173273⁷

Search outside databases for aliases for TNKS gene

Previous GC identifer: GC08P009330

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TNKS1_HUMAN, O95271

Function: May regulate vesicle trafficking and modulate the subcellular distribution of

SLC2A4/GLUT4-vesicles. Has PARP activity and can modify TERF1, and thereby contribute to the

regulation of telomere length

Gene Wiki entry for TNKS

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TNKS gene

Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1

TNKS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P009450: (about GC identifiers)

Start:	9,450,855 bp from pter
End:	9,677,266 bp from pter
Size:	226,412 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_077531.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TNKS1_HUMAN, O95271 (See protein sequence)

Recommended Name: Tankyrase-1

Size: 1327 amino acids; 142039 Da

Subunit: Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of

LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK

repeats. Found in a complex with POT1; TERF1 and TINF2

Subcellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus,

nuclear pore complex. Telomere (Potential). Note=Associated with the Golgi and with juxtanuclear

SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the

pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found

in the nucleus, associated with TERF1

PDB structures from and Proteopedia :

2RF5 (3D)

Secondary accessions: O95272

Alternative splicing: 2 isoforms: O95271-1 O95271-2

Post-translational modifications:

Phosphorylated on serine residues by MAPK kinases upon insulin stimulation¹

ADP-ribosylated (-auto)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003738.2

ENSEMBL proteins:

ENSP00000311579

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Tankyrase)
	Human Recombinant Proteins from Abnova (TNKS)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/11 Gene Ontology (GO) cellular component terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0000242	pericentriolar material	TAS	11454873
GO:0000784	nuclear chromosome, telomeric region	IDA	11739745
GO:0005634	nucleus	IEA	--
GO:0005643	nuclear pore	IEA	--

About this table

Antibodies for TNKS:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TNKS
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Tankyrase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TNKS)
	Novus Biologicals Antibodies for TNKS

Assays for TNKS:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O95271

ProtoNet protein and cluster: O95271

3 Blocks protein families:

IPB001660 Sterile alpha motif SAM

IPB002110 Ankyrin repeat signature

IPB011510 Sterile alpha motif homology 2

UniProtKB/Swiss-Prot: TNKS1_HUMAN, O95271

Similarity: Contains 15 ANK repeats

Similarity: Contains 1 PARP catalytic domain

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TNKS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TNKS)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003747

Applied Biosystems Silencer® siRNAs for TNKS

Sigma-Aldrich siRNA and siRNA Panels for TNKS

Sigma-Aldrich shRNA for TNKS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003747
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003747
untagged cDNA clones in CMV expression vector (see all 2): NM_003747

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003747

UniProtKB/Swiss-Prot: TNKS1_HUMAN, O95271

Function: May regulate vesicle trafficking and modulate the subcellular distribution of

SLC2A4/GLUT4-vesicles. Has PARP activity and can modify TERF1, and thereby contribute to the

regulation of telomere length

Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide +

(ADP-D-ribosyl)(n+1)-acceptor

Enzyme Number (IUBMB): EC 2.4.2.30

Genatlas biochemistry entry for TNKS:

tankyrase,a poly (ADP ribose) polymerase located at telomeres,centromeres and nuclear pore

complexes,binding the telomere-specific DNA binding protein TERF1 potential modulator of telomere

length

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tnks):

cellular	embryogenesis	growth/size	homeostasis/metabolism	lethality-prenatal/perinatal
no phenotypic analysis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003950	NAD+ ADP-ribosyltransferase activity	IDA	9822378
GO:0005515	protein binding	IPI	9822378 12768206
GO:0008270	zinc ion binding	IDA	18436240
GO:0016757	transferase activity, transferring glycosyl groups	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for TNKS

5/19 Interacting proteins for TNKS (O95271¹ ENSP00000311579³) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FNBP1	Q96RU3¹, ENSP00000361493³	EBI-1105254, EBI-1111248 STRING (score=.991)
TERF1	ENSP00000276603³	STRING (score=.999)
TNKS1BP1	ENSP00000350990³	STRING (score=.992)
TERF2	ENSP00000254942³	STRING (score=.987)
POT1	ENSP00000350249³	STRING (score=.969)

About this table

5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007052	mitotic spindle organization	TAS	17026964
GO:0015031	protein transport	IEA	--
GO:0018105	peptidyl-serine phosphorylation	IDA	17026964
GO:0018107	peptidyl-threonine phosphorylation	IDA	17026964
GO:0032212	positive regulation of telomere maintenance via telomerase	IMP	11739745

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TNKS
2 Novoseek chemical compound relationships for TNKS gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tin(2+)	92.46	10	17962804 (2), 17616810 (2), 15133513 (2), 15292264 (1) (see all 5)
3-aminobenzamide	57.89	1	15133513 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TNKS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TNKS)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003747

Sigma-Aldrich siRNA and siRNA Panels for TNKS

Sigma-Aldrich shRNA for TNKS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003747

REFSEQ mRNAs for TNKS gene:

NM_003747.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003747

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003747
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003747
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_003747

Additional cDNA sequence:

AB209339.1 AF070613.1 AF082556.1 AF082557.1 AF082558.1 AF082559.1 AK301798.1 AK302031.1

AK302534.1 BC098394.1 CR590086.1

13 DOTS entries:

DT.216619 DT.65288499 DT.97802352 DT.101965487 DT.306099 DT.91768757 DT.101501 DT.91768752

DT.91768766 DT.121494201 DT.95127756 DT.40122815 DT.91768751

24/239 AceView cDNA sequences (see all 239 ):

BF725059 AI424165 Z43947 AA765825 AI362226 F04348 BX955476 CA443089

Z40890 AI040551 CD108652 AI424440 AF082556 AW665966 BF477720 BG655725

AW631332 BM698336 AW068931 Z45482 AA749311 BG287954 F08801 T32850

highest scoring ESTs for TNKS:

AF082557 AA205162 AA205204 AA206870 AA206871 AA243359 AA249768 AA252630 AA293113 AA348605

Unigene Cluster for TNKS:

Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

Hs.370267 [show with all ESTs]

Unigene Representative Sequence: NM_003747

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TNKS

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25a	·	25b	^
SP1:
SP2:

ExUns:	26	^	27a	·	27b
SP1:	-
SP2:

About this scheme

ECgene alternative splicing isoforms for TNKS

1 Ensembl transcript including schematic representation:

ENST00000310430

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TNKS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TNKS

¹ / ² / ³

11 probe-sets matching TNKS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31475_at²^{, 3}	U95-A	1	1.00	1.00	0.86	0.91	AF082559	0.80	0.80	0.80	1
39430_at²^{, 3}	U95-A	1	1.00	1.00	0.55	1.44	AF082557	1.00	0.90	0.95	1
31474_r_at²^{, 3}	U95-A	1	1.00	1.00	0.50	0.89	AF082558	0.80	1.00	0.91	1
31476_g_at²^{, 3}	U95-A	1	1.00	1.00	0.07	0.23	AF082559	0.80	0.80	0.80	1
31473_s_at²^{, 3}	U95-A	1	1.00	1.00	0.07	0.45	AF082558	0.80	1.00	0.91	1
84892_at²^{, 3}	U95-D	1	0.44	1.00	0.32	0.81	AI269745	0.80	1.00	0.91	1
216695_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF082559	0.80	0.80	0.80	1
202561_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF070613	0.80	1.00	0.91	1
216695_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202561_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1569391_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTAAAGTCCT

SOURCE GeneReport for Unigene cluster: Hs.370267
Expression variation in blood from EXPOLDB for TNKS
UniProtKB/Swiss-Prot: TNKS1_HUMAN, O95271
Tissue specificity: Ubiquitous; highest levels in testis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TNKS gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TNKS¹	--	tankyrase, TRF1-interacting ankyrin-related ADP-ribose more	93.52(n) 98.94(a)	475603 XM_844295.1 XP_849388.1
chimpanzee (Pan troglodytes)	TNKS¹	--	tankyrase, TRF1-interacting ankyrin-related ADP-ribose more	99.45(n) 99.62(a)	463982 XM_001137443.1 XP_001137443.1
cow (Bos taurus)	TNKS¹	--	tankyrase, TRF1-interacting ankyrin-related ADP-ribose more	92.34(n) 98.87(a)	535030 XM_865285.2 XP_870378.1
rat (Rattus norvegicus)	Tnks¹	--	tankyrase, TRF1-interacting ankyrin-related ADP-ribose more	88.61(n) 97.95(a)	290794 XM_224923.4 XP_224923.3
mouse (Mus musculus)	Tnks⁵ Tnks¹	8 (18.00 cM)⁵	tankyrase, TRF1-interacting ankyrin-related ADP-ribose more^{1, 5}	88.91(n)¹ 97.95(a)¹	21951¹ NM_175091.3¹ NP_780300.2¹ AA415426⁵ AI048338⁵ (see all 17)

About this table Species with no ortholog for TNKS

ENSEMBL Gene Tree for TNKS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TNKS gene

TNKS2² ANKRD29²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1572 NCBI SNPs in TNKS are shown (see all 1572 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 518)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1055328^1,2	A,C,F,H,O	9676726(+)	`TTATTC/GGTGTT`	1	--	ut3¹ ese³		9	MN EU EA WA NA	964
	rs9329203^1,2	A,C,F,H	9449563(+)	`GGTTGA/GGGGAA`	1	--	ng5¹ trp³		4	EU EA WA	416
	rs13271097^1,2	A,C,F,H	9448977(+)	`TATCAC/TGTTGG`	1	--	ng5¹		11	EU EA WA NA	958
	rs9644677^1,2	A,C,F,H	9449218(+)	`CACTCA/GTAATA`	1	--	ng5¹		11	EU EA WA NA	978
	rs13260490^1,2	A,C,F,H	9449013(+)	`CTGCTC/GTACAT`	1	--	ng5¹		7	EU EA WA NA	558
	rs10109026^1,2	A,C,F,H	9449396(+)	`TCTTAC/TAGAAT`	1	--	ng5¹		8	EA NA EU WA	626
	rs6990097^1,2	A,C,F,H	9450267(+)	`AATTAT/CAGGGA`	1	--	ng5¹		9	NA EU EA WA	738
	rs9329202^1,2	A,C,F,H	9449410(+)	`CATCTA/GTGTCC`	1	--	ng5¹		7	EU EA WA NA	554
	rs1567834^1,2	A,C,F,H	9672500(+)	`GACACG/AGGCTT`	1	--	ut3¹ ese³		9	MN EU EA WA	1018
	rs17150237^1,2	C,F,H	9449129(+)	`TCTACC/TGCGAA`	1	--	ng5¹ tfbs³		11	NA EU EA WA	982

About this table

HapMap Linkage Disequilibrium images for TNKS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603303

3 Novoseek disease relationships for TNKS gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	20.01	9	18369822 (3), 15652747 (2), 17617028 (1), 16421589 (1) (see all 5)
tumors	0.00	7	17617028 (5), 15498272 (2)
leukemia	0.00	1	10753188 (1)

About this table

Human Genome Epidemiology Navigator: TNKS (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

12/63 PubMed articles for TNKS gene (see all 63 ):

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. (PubMed id 9822378)^{2, 3, 4} Smith S.... de Lange T. (1998)
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. (PubMed id 11739745)^{1, 3, 4} Cook B.D.... Smith S. (2002)
POT1 as a terminal transducer of TRF1 telomere length control. (PubMed id 12768206)^{3, 4} Loayza D. and De Lange T. (2003)
Tankyrase is a Golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles. (PubMed id 10988299)^{3, 4} Chi N.-W. and Lodish H.F. (2000)
Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes. (PubMed id 10523501)^{3, 4} Smith S. and de Lange T. (1999)
Chromosomal mapping of the tankyrase gene in human and mouse. (PubMed id 10198177)^{2, 3} Zhu L....Seldin M.F. (1999)
NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis. (PubMed id 16076287)^{1, 3} Chang W....Smith S. (2005)
Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). (PubMed id 11802774)^{1, 3} Sbodio J.I.... Chi N.-W. (2002)
The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). (PubMed id 11854288)^{1, 3} Seimiya H. and Smith S. (2002)
Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation. (PubMed id 14966275)^{1, 3} Seimiya H....Tsuruo T. (2004)
The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance. (PubMed id 14596906)^{1, 3} Fuchs U.... Borkhardt A. (2003)
Upregulation of telomerase activity by X-irradiation in mouse leukaemia cells is independent of Tert, Terc, Tnks and Myc transcription. (PubMed id 10753188)¹ Finnon P....Bouffler S.D. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Search String
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8658	HGNC: 11941	AceView: TNKS	Ensembl:ENSG00000173273	euGenes: HUgn8658
ECgene: TNKS	H-InvDB: TNKS

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for TNKS
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TNKS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TNKS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TNKS		Antibodies for TNKS
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TNKS		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TNKS)
	Antibodies (TNKS)
	Chimera RNAi (TNKS)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Tankyrase)
	Antibodies (Tankyrase)

Search OriGene for TNKS

Search Tocris compounds for TNKS

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TNKS

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TNKS Gene at Home site.
Version 2.41.1
server5.xennexinc.com

TNKS Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for TNKS

Summaries
for TNKS

Genomic Location
for TNKS

Proteins
for TNKS

Protein Domains/
Families
for TNKS

Gene Function
for TNKS

Pathways & Interactions
for TNKS

Drugs & Compounds
for TNKS

Transcripts
for TNKS

Expression
for TNKS

Orthologs
for TNKS

Paralogs
for TNKS

SNPs/Variants
for TNKS

Disorders & Mutations
for TNKS

Medical News
for TNKS

Publications
for TNKS

Search for TNKS

Genome Databases showing TNKS

Other Databases showing TNKS

Specialized Databases showing TNKS

Licensable Technologies
for TNKS

Services
for TNKS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TNKS Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor TNKS

Summariesfor TNKS

Genomic Locationfor TNKS

Proteinsfor TNKS

Protein Domains/Familiesfor TNKS

Gene Functionfor TNKS

Pathways & Interactionsfor TNKS

Drugs & Compoundsfor TNKS

Transcriptsfor TNKS

Expression for TNKS

Orthologsfor TNKS

Paralogsfor TNKS

SNPs/Variantsfor TNKS

Disorders & Mutationsfor TNKS

Medical Newsfor TNKS

Publicationsfor TNKS

Search for TNKS

Genome Databases showing TNKS

Other Databases showing TNKS

Specialized Databases showing TNKS

Licensable Technologiesfor TNKS

Servicesfor TNKS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TNKS

Summaries
for TNKS

Genomic Location
for TNKS

Proteins
for TNKS

Protein Domains/
Families
for TNKS

Gene Function
for TNKS

Pathways & Interactions
for TNKS

Drugs & Compounds
for TNKS

Transcripts
for TNKS

Expression
for TNKS

Orthologs
for TNKS

Paralogs
for TNKS

SNPs/Variants
for TNKS

Disorders & Mutations
for TNKS

Medical News
for TNKS

Publications
for TNKS

Licensable Technologies
for TNKS

Services
for TNKS