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TNKS Gene

protein-coding   GIFtS: 68
GCID: GC08P009413

Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase1 2     TNKS-12 3
Poly [ADP-Ribose] Polymerase 5A2 3     TNKS12 3
Tankyrase I2 3     ADP-Ribosyltransferase Diphtheria Toxin-Like 52 3
ARTD52 3     TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase2 3
PARP5A2 3     PARP-5a2
PARPL2 3     pART52
TANK12 3     tankyrase-12
TIN12 3     EC 2.4.2.303
TINF12 3     

External Ids:    HGNC: 119411   Entrez Gene: 86582   Ensembl: ENSG000001732737   OMIM: 6033035   UniProtKB: O952713   

Export aliases for TNKS gene to outside databases

Previous GC identifers: GC08P009330 GC08P009450 GC08P008339


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TNKS Gene:
TNKS (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase) is a protein-coding gene. Diseases associated with TNKS include cerebral atherosclerosis, and diphtheria. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is TNKS2.

UniProtKB/Swiss-Prot: TNKS1_HUMAN, O95271
Function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length
and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation
(PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated
target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also
mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination.
Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome
maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking
and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly
through PARsylation of NUMA1. Stimulates 26S proteasome activity

summary for TNKS Gene:
Tankyrases 1 and 2 (TNKS1/PARP5A and TNKS2/PARP5B/PARP5C) are proteins with poly(ADP-ribose) polymerase
activity. Human tankyrases post-translationally modify multiple proteins involved in processes including
maintenance of telomere length, sister telomere association, insulin responsiveness, spindle assembly and
trafficking of glut4-containing vesicles. Recently tankyrases have been shown be involved in the wnt
signaling pathway. Tankyrases bind directly to axin, a member of the 'destruction complex' involved in
beta-catenin degradation. Inhibition of tankyrase stabilizes axin, increases the activity of the destruction
complex and promotes degradation of beta-catenin. Tankyrases are therefore an attractive target anticancer
therapies.

Gene Wiki entry for TNKS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_077531.5  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNKS gene promoter:
         TBP   Sp1   p300   Gfi-1   CREB   Max   deltaCREB   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNKS promoter sequence
   Search Chromatin IP Primers for TNKS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNKS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

TNKS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNKS gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P009413:  view genomic region     (about GC identifiers)

Start:
9,413,424 bp from pter      End:
9,639,856 bp from pter
Size:
226,433 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TNKS1_HUMAN, O95271 (See protein sequence)
Recommended Name: Tankyrase-1  
Size: 1327 amino acids; 142039 Da
Subunit: Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in
SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with
POT1; TERF1 and TINF2. Interacts with AXIN1, AXIN2, BLZF1 and CASC3
Selected PDB 3D structures from and Proteopedia for TNKS (see all 17):
2RF5 (3D)        3UDD (3D)        3UH2 (3D)        3UH4 (3D)        4DVI (3D)        4I9I (3D)    
Secondary accessions: O95272 Q4G0F2
Alternative splicing: 2 isoforms:  O95271-1   O95271-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNKS: NX_O95271

Explore proteomics data for TNKS at MOPED

Post-translational modifications: 

  • Phosphorylated on serine residues by MAPK kinases upon insulin stimulation. Phosphorylated during mitosis1
  • Ubiquitinated by RNF146 when auto-poly-ADP-ribosylated, leading to its degradation1
  • ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination1
  • Ubiquitination2 at Lys210, Lys767
  • Modification sites at PhosphoSitePlus

  • See TNKS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003738.2  
    ENSEMBL proteins: 
     ENSP00000428299   ENSP00000311579   ENSP00000430920   ENSP00000429890   ENSP00000431098  
     ENSP00000428185  
    Reactome Protein details: O95271

    TNKS Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TNKS
    GenScript Custom Purified and Recombinant Proteins Services for TNKS
    Novus Biologicals TNKS Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TNKS Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TNKS (Tankyrase 1)
    OriGene Antibodies for TNKS
    OriGene Custom Antibody Services for TNKS
    Novus Biologicals TNKS Antibodies
    Abcam antibodies for TNKS
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for TNKS
    LSBio Antibodies in human, mouse, rat for TNKS

    TNKS Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for TNKS (Tankyrase 1)
    GenScript Custom Assay Services for TNKS
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PARP: Poly (ADP-ribose) polymerases
    ANKRD: Ankyrin repeat domain containing
    SAMD: Sterile alpha motif (SAM) domain containing

    Selected InterPro protein domains (see all 7):
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR011510 SAM_2
     IPR020683 Ankyrin_rpt-contain_dom
     IPR012317 Poly(ADP-ribose)pol_cat_dom

    Graphical View of Domain Structure for InterPro Entry O95271

    ProtoNet protein and cluster: O95271

    3 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB002110 Ankyrin repeat signature
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: TNKS1_HUMAN, O95271
    Similarity: Contains 15 ANK repeats
    Similarity: Contains 1 PARP catalytic domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    TNKS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNKS1_HUMAN, O95271
    Function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length
    and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation
    (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated
    target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also
    mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination.
    Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome
    maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking
    and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly
    through PARsylation of NUMA1. Stimulates 26S proteasome activity
    Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
    Enzyme regulation: Specifically inhibited by XAV939, a small molecule, leading to inhibit the Wnt signaling
    pathway by stabilizing AXIN1 and AXIN2

         Genatlas biochemistry entry for TNKS:
    tankyrase,a poly (ADP ribose) polymerase located at telomeres,centromeres and nuclear pore complexes,binding the
    telomere-specific DNA binding protein TERF1 potential modulator of telomere length

         Enzyme Number (IUBMB): EC 2.4.2.301

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NAD+ ADP-ribosyltransferase activity IDA19759537
    GO:0005515protein binding IPI12768206
    GO:0008270zinc ion binding IDA18436240
         
    TNKS for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tnks):
     adipose tissue  behavior/neurological  cellular  embryogenesis  growth/size/body 
     homeostasis/metabolism  integument  mortality/aging  muscle  no phenotypic analysis 

    TNKS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tnkstm1.1Yjc for TNKS

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNKS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNKS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNKS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNKS

    miRNA
    Products:
        
    miRTarBase miRNAs that target TNKS:
    hsa-mir-744-5p (MIRT037431), hsa-mir-324-3p (MIRT043012), hsa-mir-26b-5p (MIRT028854), hsa-mir-324-5p (MIRT043016)

    Block miRNA regulation of human, mouse, rat TNKS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNKS (see all 92):
    hsa-miR-548j hsa-miR-607 hsa-miR-3607-3p hsa-miR-30d hsa-miR-30a hsa-miR-298 hsa-miR-149 hsa-miR-4274
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TNKS
    Predesigned siRNA for gene silencing in human, mouse, rat TNKS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TNKS

    Clone
    Products:
         
    OriGene clones in human, mouse for TNKS (see all 8)
    OriGene ORF clones in mouse, rat for TNKS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNKS (NM_003747)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNKS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNKS

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TNKS
    Browse ESI BIO Cell Lines and PureStem Progenitors for TNKS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNKS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNKS1_HUMAN, O95271: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Chromosome, centromere.
    Nucleus, nuclear pore complex. Chromosome, telomere (Potential). Cytoplasm, cytoskeleton, spindle pole.
    Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at
    nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small
    fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via
    interaction with NUMA1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus5
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0000242pericentriolar material TAS11454873
    GO:0000775chromosome, centromeric region IEA--
    GO:0000781chromosome, telomeric region IDA9822378
    GO:0000784nuclear chromosome, telomeric region IDA11739745

    TNKS for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNKS About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptotic Pathways in Synovial Fibroblasts
    Telomerase Components in Cell Signaling0.72
    2Nicotinate and nicotinamide metabolism
    NAD metabolism0.43
    3Telomere Extension by Telomerase
    Telomere Extension by Telomerase
    4Regulation of Telomerase
    Regulation of Telomerase

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNKS
        Telomerase Components in Cell Signaling
    Telomere Extension by Telomerase

    1 GeneGo (Thomson Reuters) Pathway for TNKS
        NAD metabolism

    1 BioSystems Pathway for TNKS
        Regulation of Telomerase

    2 Reactome Pathways for TNKS
        degradation of AXIN
    TCF dependent signaling in response to WNT



    TNKS for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNKS: 
              Cancer Drug Targets in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Telomeres & Telomerase in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNKS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for TNKS (O952711, 2, 3 ENSP000003115794) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FNBP1Q96RU31, 2, 3, ENSP000004136254EBI-1105254,EBI-1111248 MINT-7027181 MINT-7027206 MINT-7026692 MINT-7027261 MINT-7027245 MINT-7027162 MINT-7027223 I2D: score=6 STRING: ENSP00000413625
    HIF1ANQ9NWT61, 2, 3, ENSP000002991634EBI-1105254,EBI-745632 MINT-8084882 MINT-8084923 I2D: score=1 STRING: ENSP00000299163
    TERF1P542742, 3, ENSP000002766034MINT-7987677 MINT-7987977 MINT-7987689 I2D: score=5 STRING: ENSP00000276603
    CENPJQ9HC771, 2EBI-1105254,EBI-946194 MINT-8398637 MINT-8398667 MINT-8398617 MINT-8398586
    BABAM1Q9NWV83, ENSP000003524084I2D: score=2 STRING: ENSP00000352408
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA19759537
    GO:0006471protein ADP-ribosylation IDA--
    GO:0007052mitotic spindle organization TAS17026964
    GO:0007067mitosis IEA--
    GO:0015031protein transport IEA--

    TNKS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    1 ApexBio Compound for TNKS     About this table
    CompoundAction CAS #
    Tankyrase Inhibitors (TNKS) 49Tankyrase 49 is an enzyme that in humans is encoded by the TNKS gene--

    Compounds for TNKS available from Tocris Bioscience    About this table
    CompoundAction CAS #
    WIKI4Tankyrase inhibitor; inhibits Wnt signaling[838818-26-1]
    NU 1025Potent PARP inhibitor[90417-38-2]
    XAV 939Tankyrase inhibitor; inhibits Wnt signaling[284028-89-3]
    JW 55Tankyrase inhibitor; inhibits canonical Wnt signaling[664993-53-7]
    PJ 34 hydrochloridePotent PARP inhibitor[344458-15-7]

    3 HMDB Compounds for TNKS    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--

    3 Novoseek inferred chemical compound relationships for TNKS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tin(2+) 91.3 10 17962804 (2), 17616810 (2), 15133513 (2), 15292264 (1) (see all 5)
    adpribose 57.6 3 20421936 (1), 19096204 (1), 14596906 (1)
    3-aminobenzamide 55.9 1 15133513 (1)



    TNKS for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TNKS gene: 
    NM_003747.2  

    Unigene Cluster for TNKS:

    Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
    Hs.370267  [show with all ESTs]
    Unigene Representative Sequence: NM_003747
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520408(uc011kwv.1) ENST00000310430(uc003wss.3 uc011kww.2)
    ENST00000522110 ENST00000517652 ENST00000518281(uc010lrs.1 uc010lrt.1)
    ENST00000518027 ENST00000521039 ENST00000519392 ENST00000517989 ENST00000519930
    ENST00000518635 ENST00000519191 ENST00000517770
    miRNA
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    Block miRNA regulation of human, mouse, rat TNKS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNKS (see all 92):
    hsa-miR-548j hsa-miR-607 hsa-miR-3607-3p hsa-miR-30d hsa-miR-30a hsa-miR-298 hsa-miR-149 hsa-miR-4274
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat TNKS
    Clone
    Products:
         
    OriGene clones in human, mouse for TNKS (see all 8)
    OriGene ORF clones in mouse, rat for TNKS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNKS (NM_003747)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNKS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNKS
    Primer
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    OriGene qPCR primer pairs and template standards for TNKS
    OriGene qSTAR qPCR primer pairs in human, mouse for TNKS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNKS
      QuantiTect SYBR Green Assays in human, mouse, rat TNKS
      QuantiFast Probe-based Assays in human, mouse, rat TNKS

    Additional mRNA sequence: 

    AB209339.1 AF070613.1 AF082556.1 AF082557.1 AF082558.1 AF082559.1 AK301798.1 AK302031.1 
    AK302534.1 BC098394.1 

    13 DOTS entries:

    DT.216619  DT.65288499  DT.97802352  DT.101965487  DT.306099  DT.91768757  DT.101501  DT.91768752 
    DT.91768766  DT.121494201  DT.95127756  DT.40122815  DT.91768751 

    Selected AceView cDNA sequences (see all 239):

    Z43947 D31296 AW298564 AW631332 CB857805 BQ271657 BM698336 AA749311 
    AW068931 AL598169 AW665966 CD359050 CR590086 BF725059 AF070613 AA765825 
    AF082559 F11131 CA443089 AF082556 T32850 BU160130 CD673173 AA252630 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TNKS    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            

    ExUns: 26 ^ 27a · 27b
    SP1:  -               
    SP2:                  


    ECgene alternative splicing isoforms for TNKS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNKS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAAGTCCT
    TNKS Expression
    About this image


    TNKS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    TNKS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNKS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370267

    UniProtKB/Swiss-Prot: TNKS1_HUMAN, O95271
    Tissue specificity: Ubiquitous; highest levels in testis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNKS: 
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              Telomeres & Telomerase in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TNKS gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnks1 , 5 tankyrase, TRF1-interacting ankyrin-related ADP-ribose more1, 5 88.51(n)1
    97.42(a)1
      8 (21.16 cM)5
    219511  NM_175091.31  NP_780300.21 
     348291795 
    chicken
    (Gallus gallus)
    Aves TNKS1 tankyrase, TRF1-interacting ankyrin-related ADP-ribose more 82.9(n)
    96.48(a)
      374252  NM_204340.1  NP_989671.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNKS6
    tankyrase, TRF1-interacting ankyrin-related ADP-ri...
    92(a)
    1 ↔ 1
    GL343257.1(1326196-1409725)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.35252 Xenopus laevis transcribed sequence with strong similarity more 81.58(n)    CD254578.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570728042   -- 76.7(n)    57072804 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD225483
    tankyrase1
    cytoskeletal anchoring structural
    constituent more3
    tankyrase1
    64(a)3
    62.38(n)1
    68.72(a)1
      430951  NM_001276034.11  NP_001262963.11 


    ENSEMBL Gene Tree for TNKS (if available)
    TreeFam Gene Tree for TNKS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNKS gene
    TNKS22  ANK32  ANK12  ANKRD522  ANKRD652  ANKFY12  ANKRD502  INVS2  
    ANK22  ANKRD282  
    Selected SIMAP similar genes for TNKS using alignment to 5 protein entries:     TNKS1_HUMAN (see all proteins) (see all similar genes):
    TNKS2    ANKRD42    ANKRD44    CDKN2A    ANK2    RAI14
    DKFZp761E1322    MTPN    GABPB1    IkBa    KIDINS220    PPP1R12A
    PPP1R27    KANK4    PSMD10    ANKRD65    HACE1    ANKRD54

    TNKS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNKS (see all 5809)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899034441,2
    --9411472(+) CTGACC/GACTGG 1 -- us2k10--------
    rs132710971,2
    C,F,A,H--9411567(+) TATCAC/TGTTGG 1 -- us2k123Minor allele frequency- T:0.34NA NS EA WA CSA 1334
    rs132604901,2
    C,F,A,H--9411603(+) CTGCTC/GTACAT 1 -- us2k118Minor allele frequency- G:0.07NA NS EA WA CSA 694
    rs132636571,2
    H--9411646(+) AGAAGA/GATGTT 1 -- us2k14Minor allele frequency- G:0.00NS EA 412
    rs132676081,2
    H--9411674(+) GCACTG/TATGTG 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs132783461,2
    H--9411676(+) ACTGAT/GGTGAG 1 -- us2k14Minor allele frequency- G:0.00NS EA 418
    rs132708441,2
    H--9411699(+) GCTACA/CCTTTT 1 -- us2k14Minor allele frequency- C:0.00NS EA 410
    rs132697731,2
    H--9411700(+) CTACAC/ATTTTT 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs171553901,2
    C,F,H--9411709(+) TTGTCA/CGGTGT 1 -- us2k117Minor allele frequency- C:0.07NA NS EA WA CSA 694
    rs171502371,2
    C,F,H--9411719(+) TCTACC/TGCGAA 1 -- us2k1 tfbs332Minor allele frequency- T:0.33NA NS EA WA CSA 2900

    HapMap Linkage Disequilibrium report for TNKS (9413424 - 9639856 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TNKS (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736579CNV Deletion23290073
    esv2736578CNV Deletion23290073
    esv2673959CNV Deletion23128226
    esv2509921CNV Deletion19546169
    esv2661157CNV Deletion23128226
    esv2736580CNV Deletion23290073
    nsv435864CNV Deletion17901297
    esv2678826CNV Deletion23128226
    esv995663CNV Deletion20482838
    esv2147282CNV Deletion18987734

    Human Gene Mutation Database (HGMD): TNKS
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNKS
    DNA2.0 Custom Variant and Variant Library Synthesis for TNKS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603303    OMIM disorders: --

    Selected diseases for TNKS (see all 27):    
    About MalaCards
    cerebral atherosclerosis    diphtheria    cherubism    cornelia de lange syndrome
    tongue cancer    congenital diaphragmatic hernia    cerebrovascular disease    fanconi's anemia
    lung cancer susceptibility    atherosclerosis    herpes simplex    cerebritis
    astrocytoma    asthma    hepatitis b    schizophrenia
    hypoxia    retinitis    obesity    lung cancer

    1 disease from the University of Copenhagen DISEASES database for TNKS:
    Cerebral atherosclerosis

    TNKS for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TNKS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 31 9 18369822 (3), 15652747 (2), 17617028 (1), 16421589 (1) (see all 5)
    leukemia 0 1 10753188 (1)
    tumors 0 7 17617028 (5), 15498272 (2)

    Genetic Association Database (GAD): TNKS
    Human Genome Epidemiology (HuGE) Navigator: TNKS (13 documents)

    Export disorders for TNKS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNKS gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with TNKS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. (PubMed id 9822378)1, 2, 3 Smith S.... de Lange T. (Science 1998)
    2. NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis. (PubMed id 16076287)1, 2, 9 Chang W.... Smith S. (Biochem. J. 2005)
    3. Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. (PubMed id 11739745)1, 2, 9 Cook B.D.... Smith S. (Mol. Cell. Biol. 2002)
    4. Zinc binding catalytic domain of human tankyrase 1. (PubMed id 18436240)1, 2, 9 Lehtio L....Weigelt J. (J. Mol. Biol. 2008)
    5. Polymorphisms in telomere maintenance genes and risk of lung cancer. (PubMed id 19773453)1, 4, 9 Choi J.E....Park J.Y. (amp 2009)
    6. Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis. (PubMed id 19766477)1, 4, 9 Varadi V....FAPrsti A. (Eur. J. Cancer 2009)
    7. Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. (PubMed id 20421936)1, 4, 9 Scherag A....Meyre D. (PLoS Genet. 2010)
    8. Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation. (PubMed id 22864114)1, 2 Ozaki Y.... Inaba T. (Mol. Cell 2012)
    9. RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. (PubMed id 21478859)1, 2 Zhang Y.... Cong F. (Nat. Cell Biol. 2011)
    10. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8658 HGNC: 11941 AceView: TNKS Ensembl:ENSG00000173273 euGenes: HUgn8658
    ECgene: TNKS H-InvDB: TNKS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNKS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNKS Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNKS gene:
    Search GeneIP for patents involving TNKS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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