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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNKS Gene

protein-coding   GIFtS: 66
GCID: GC08P009450

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
 Explore 21 diseases affiliated with
TNKS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TNKS    

Aliases
for TNKS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase1 2     ARTD52 3
PARP5A1 2 3     PARPL2 3
TIN11 2 3     TANK12 3
TINF11 2 3     TNKS-12 3
TNKS11 2 3     ADP-Ribosyltransferase Diphtheria Toxin-Like 52 3
PARP-5a1 2     TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase2 3
PART51     Tankyrase-11
Poly [ADP-Ribose] Polymerase 5A2 3     EC 2.4.2.303
Tankyrase I2 3     

External Ids:    HGNC: 119411   Entrez Gene: 86582   Ensembl: ENSG000001732737   OMIM: 6033035   UniProtKB: O952713   

Export aliases for TNKS gene to outside databases

Previous GC identifers: GC08P009330 GC08P008339


Summaries
for TNKS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TNKS1_HUMAN, O95271
Function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and
vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation
(PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated
target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also
mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates
PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation
during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the
subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of
NUMA1

summary for TNKS:
Tankyrases 1 and 2 (TNKS1/PARP5A and TNKS2/PARP5B/PARP5C) are proteins with poly(ADP-ribose) polymerase
activity. Human tankyrases post-translationally modify multiple proteins involved in processes including
maintenance of telomere length, sister telomere association, insulin responsiveness, spindle assembly and
trafficking of glut4-containing vesicles. Recently tankyrases have been shown be involved in the wnt
signaling pathway. Tankyrases bind directly to axin, a member of the 'destruction complex' involved in
beta-catenin degradation. Inhibition of tankyrase stabilizes axin, increases the activity of the destruction
complex and promotes degradation of beta-catenin. Tankyrases are therefore an attractive target anticancer
therapies.

Gene Wiki entry for TNKS


Genomic Views
for TNKS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_077531.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNKS gene promoter:
         TBP   Sp1   p300   Gfi-1   CREB   Max   deltaCREB   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNKS promoter sequence
   Search SABiosciences Chromatin IP Primers for TNKS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNKS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

TNKS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNKS gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P009450:  view genomic region     (about GC identifiers)

Start:
 9,413,424 bp from pter      End:
 9,639,856 bp from pter
Size:
 226,433 bases      Orientation:
 plus strand

Proteins
for TNKS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TNKS1_HUMAN, O95271 (See protein sequence)
Recommended Name: Tankyrase-1  
Size: 1327 amino acids; 142039 Da
Subunit: Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in
SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1;
TERF1 and TINF2. Interacts with AXIN1, AXIN2, BLZF1 and CASC3
Subcellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Chromosome, centromere.
Nucleus, nuclear pore complex. Chromosome, telomere (Potential). Cytoplasm, cytoskeleton, spindle pole.
Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at
nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small
fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via
interaction with NUMA1
6 PDB 3D structures from and Proteopedia for TNKS:
2RF5 (3D)        3UDD (3D)        3UH2 (3D)        3UH4 (3D)        4DVI (3D)        4I9I (3D)    
Secondary accessions: O95272 Q4G0F2
Alternative splicing: 2 isoforms:  O95271-1   O95271-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNKS: NX_O95271

Post-translational modifications:

  • Phosphorylated on serine residues by MAPK kinases upon insulin stimulation. Phosphorylated during mitosis1
  • Ubiquitinated by RNF146 when auto-poly-ADP-ribosylated, leading to its degradation1
  • ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95271

    • TNKS Protein expression data from MOPED and PaxDb:    About this image 
    TNKS Protein Expression
    REFSEQ proteins: NP_003738.2  
    ENSEMBL proteins: 
     ENSP00000428299   ENSP00000311579   ENSP00000430920   ENSP00000429890   ENSP00000431098  
     ENSP00000428185  

    Human Recombinant Protein Products for TNKS: 
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    Novus Biologicals TNKS Proteins
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TNKS

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0000242pericentriolar material TAS11454873
    GO:0000775chromosome, centromeric region IEA--
    GO:0000781chromosome, telomeric region IDA9822378
    GO:0000784nuclear chromosome, telomeric region IDA11739745

    TNKS for ontologies           About GeneDecksing



    TNKS Antibody Products: 
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    Abcam antibodies for TNKS 
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    ThermoFisher Antibodies for TNKS

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    Uscn ELISAs and CLIAs for TNKS

    Protein Domains /
    Families
    for TNKS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TNKS for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR011510 SAM_2
     IPR020683 Ankyrin_rpt-contain_dom
     IPR012317 Poly(ADP-ribose)pol_cat_dom

    Graphical View of Domain Structure for InterPro Entry O95271

    ProtoNet protein and cluster: O95271

    3 Blocks protein families:
    IPB001660 Sterile alpha motif SAM
    IPB002110 Ankyrin repeat signature
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: TNKS1_HUMAN, O95271
    Similarity: Contains 15 ANK repeats
    Similarity: Contains 1 PARP catalytic domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Function
    for TNKS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNKS1_HUMAN, O95271
    Function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and
    vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation
    (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated
    target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also
    mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates
    PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation
    during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the
    subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of
    NUMA1
    Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
    Enzyme regulation: Specifically inhibited by XAV939, a small molecule, leading to inhibit the Wnt signaling pathway by
    stabilizing AXIN1 and AXIN2

         Genatlas biochemistry entry for TNKS:
    tankyrase,a poly (ADP ribose) polymerase located at telomeres,centromeres and nuclear pore complexes,binding the
    telomere-specific DNA binding protein TERF1 potential modulator of telomere length

         Enzyme Number (IUBMB): EC 2.4.2.301

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NAD+ ADP-ribosyltransferase activity IDA--
    GO:0005515protein binding IPI19759537
    GO:0008270zinc ion binding IDA18436240
         
    TNKS for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tnks):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  embryogenesis 
     growth/size  homeostasis/metabolism  mortality/aging  muscle  no phenotypic analysis 

    TNKS for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Tnkstm1.1Yjc for TNKS
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TNKS 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: TNKS
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNKS
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate TNKS (see all 92):
    hsa-miR-548j hsa-miR-607 hsa-miR-3607-3p hsa-miR-30d hsa-miR-30a hsa-miR-298 hsa-miR-149 hsa-miR-4274
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNKS (see all 7)
    OriGene shRNA RFP: TNKS
    OriGene siRNA: TNKS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNKS
    Sirion Biotech Custom design and validation of potent shRNA sequences against TNKS 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TNKS
    Sirion Biotech Customized adenovirus for overexpression of TNKS 
    Sirion Biotech Customized adenovirus for potent knockdown of TNKS

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNKS (see all 3)
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    GenScript: all cDNA clones in your preferred vector: TNKS (NM_003747)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNKS 

    Cell Line
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    Search LifeMap BioReagents cell lines for TNKS
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNKS


    Pathways & Interactions
    for TNKS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1NAD metabolism
    		NAD metabolism1.00
    		NAD metabolism1.00
    2Telomere Extension by Telomerase
    		Telomere Extension by Telomerase1.00
    3Regulation of Telomerase
    		Regulation of Telomerase1.00
    4Apoptotic Pathways in Synovial Fibroblasts
    		Telomerase Components in Cell Signaling0.72

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TNKS
        NAD metabolism

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNKS
        Telomerase Components in Cell Signaling
    Telomere Extension by Telomerase

    1 GeneGo (Thomson Reuters) Pathway for TNKS
        NAD metabolism

    1 BioSystems Pathway for TNKS 
        Regulation of Telomerase



    TNKS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNKS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/27 Interacting proteins for TNKS (O952711, 2, 3 ENSP000003115794) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FNBP1Q96RU31, 2, 3, ENSP000004136254EBI-1105254,EBI-2948562 MINT-7027181 MINT-7027206 MINT-7026692 MINT-7027261 MINT-7027245 MINT-7027162 MINT-7027223 I2D: score=6 STRING: ENSP00000413625
    TERF1P542742, 3, ENSP000002766034MINT-7987677 MINT-7987977 MINT-7987689 I2D: score=5 STRING: ENSP00000276603
    HIF1ANQ9NWT62, 3, ENSP000002991634MINT-8084882 MINT-8084923 I2D: score=1 STRING: ENSP00000299163
    CENPJQ9HC772MINT-8398637 MINT-8398667 MINT-8398617 MINT-8398586
    BABAM1Q9NWV83, ENSP000003524084I2D: score=2 STRING: ENSP00000352408
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA19759537
    GO:0006471protein ADP-ribosylation IDA9822378
    GO:0007052mitotic spindle organization TAS17026964
    GO:0007067mitosis IEA--
    GO:0015031protein transport IEA--

    TNKS for ontologies           About GeneDecksing



    Drugs & Compounds
    for TNKS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNKS for compounds           About GeneDecksing

    EMD Millipore small molecules for TNKS:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for TNKS available from Tocris Bioscience    About this table
    CompoundAction CAS #
    XAV 939Tankyrase inhibitor; inhibits Wnt signaling[284028-89-3]
    JW 55Tankyrase inhibitor; inhibits canonical Wnt signaling[664993-53-7]

    3 HMDB Compounds for TNKS    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--
    3 Novoseek chemical compound relationships for TNKS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tin(2+) 91.3 10 17962804 (2), 17616810 (2), 15133513 (2), 15292264 (1) (see all 5)
    adpribose 57.6 3 20421936 (1), 19096204 (1), 14596906 (1)
    3-aminobenzamide 55.9 1 15133513 (1)

    Search CenterWatch for drugs/clinical trials and news about TNKS / TNKS1 

    Transcripts
    for TNKS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TNKS gene: 
    NM_003747.2  

    Unigene Cluster for TNKS:

    Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
    Hs.370267  [show with all ESTs]
    Unigene Representative Sequence: NM_003747
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520408(uc011kwv.1) ENST00000310430(uc003wss.3 uc011kww.2)
    ENST00000522110 ENST00000517652 ENST00000518281(uc010lrs.1 uc010lrt.1)
    ENST00000518027 ENST00000521039 ENST00000519392 ENST00000517989 ENST00000519930
    ENST00000518635 ENST00000519191 ENST00000517770

    miRNA
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    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate TNKS (see all 92):
    hsa-miR-548j hsa-miR-607 hsa-miR-3607-3p hsa-miR-30d hsa-miR-30a hsa-miR-298 hsa-miR-149 hsa-miR-4274
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNKS (see all 7)
    OriGene shRNA RFP: TNKS
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNKS
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNKS

    Additional cDNA sequence: 

    AB209339.1 AF070613.1 AF082556.1 AF082557.1 AF082558.1 AF082559.1 AK301798.1 AK302031.1 
    AK302534.1 BC098394.1 

    13 DOTS entries:

    DT.216619  DT.65288499  DT.97802352  DT.101965487  DT.306099  DT.91768757  DT.101501  DT.121494201 
    DT.91768752  DT.91768766  DT.95127756  DT.40122815  DT.91768751 

    24/239 AceView cDNA sequences (see all 239):

    BM698336 AA765825 Z43947 AA731310 F11131 AI972909 CB306110 T32850 
    CD673173 CB857805 F04348 AL046214 CD108652 CD723504 AI017504 BQ271657 
    AW631332 AI147680 BM712318 AF070613 AW298564 BM509053 AA358823 Z40890 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TNKS    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            

    ExUns: 26 ^ 27a · 27b
    SP1:  -               
    SP2:                  


    ECgene alternative splicing isoforms for TNKS

    Expression
    for TNKS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNKS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAAAGTCCT
    TNKS Expression
    About this image

    TNKS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyCap MesenchymeCap Mesenchyme CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TNKS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNKS

    SOURCE GeneReport for Unigene cluster: Hs.370267

    UniProtKB/Swiss-Prot: TNKS1_HUMAN, O95271
    Tissue specificity: Ubiquitous; highest levels in testis

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNKS: 
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              Cancer PathwayFinder in human mouse rat
              Telomeres & Telomerase in human mouse rat

    Primer
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    Orthologs
    for TNKS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TNKS gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TNKS1 tankyrase, TRF1-interacting ankyrin-related ADP-ribose more 82.17(n)
    94.62(a)    		   374252  NM_204340.1  NP_989671.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TNKS6
    		 --
    		 91(a)
    		 1 ↔ 1
    		 GL343257.1(1326196-1409725)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.35252 Xenopus laevis transcribed sequence with strong similarity more 81.58(n)    CD254578.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii 570728042   -- 76.7(n)    57072804 
    fruit fly
    (Drosophila melanogaster)    		 Insecta BcDNA:LD225483 cytoskeletal anchoring structural
    constituent more    		 64(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea trp-46
    		 TRP (transient receptor potential) channel family ...
    		 8(a)
    		 possible ortholog
    		 I(13899073-13913954)


    ENSEMBL Gene Tree for TNKS (if available)
    TreeFam Gene Tree for TNKS (if available) 

    Paralogs
    for TNKS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNKS gene
    TANC22  TNKS22  ANKRD172  ANK32  ANKHD12  ANK12  ANKRD522  ANKHD1-EIF4EBP32  
    ANKRD502  TANC12  INVS2  ANKRD282  ANK22  ANKRD442  
    18/22 SIMAP similar genes for TNKS using alignment to 5 protein entries:     TNKS1_HUMAN (see all proteins) (see all similar genes):
    TNKS2    ANKRD42    ANKRD44    CDKN2A    ANK2    RAI14
    DKFZp761E1322    MTPN    GABPB1    IkBa    KIDINS220    PPP1R12A
    PPP1R27    KANK4    PSMD10    ANKRD65    HACE1    ANKRD54

    TNKS for paralogs           About GeneDecksing



    Genomic Variants
    for TNKS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4952 NCBI SNPs in TNKS are shown (see all 4952)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1899034441,2
    		--9411472(+) CTGACC/GACTGG 1 -- us2k10--------
    rs132710971,2
    		C,F,A,H--9411567(+) TATCAC/TGTTGG 1 -- us2k123Minor allele frequency- T:0.34NA NS EA WA CSA 1334
    rs132604901,2
    		C,F,A,H--9411603(+) CTGCTC/GTACAT 1 -- us2k118Minor allele frequency- G:0.07NA NS EA WA CSA 694
    rs132636571,2
    		H--9411646(+) AGAAGA/GATGTT 1 -- us2k14Minor allele frequency- G:0.00NS EA 412
    rs132676081,2
    		H--9411674(+) GCACTG/TATGTG 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs132783461,2
    		H--9411676(+) ACTGAT/GGTGAG 1 -- us2k14Minor allele frequency- G:0.00NS EA 418
    rs132708441,2
    		H--9411699(+) GCTACA/CCTTTT 1 -- us2k14Minor allele frequency- C:0.00NS EA 410
    rs132697731,2
    		H--9411700(+) CTACAC/ATTTTT 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs171553901,2
    		C,F,H--9411709(+) TTGTCA/CGGTGT 1 -- us2k117Minor allele frequency- C:0.07NA NS EA WA CSA 694
    rs171502371,2
    		C,F,H--9411719(+) TCTACC/TGCGAA 1 -- us2k1 tfbs332Minor allele frequency- T:0.33NA NS EA WA CSA 2900

    HapMap Linkage Disequilibrium report for TNKS (9413424 - 9639856 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 29 variations for TNKS
         9 CNVs: 65051 36894 23010 95238 59496 95239 100267 82471 44363
         4 Indels: 100266 70277 10851 10807
         15/16 Inversions (see all 16): 37318 37316 37307 37317 37311 37319 37320 37315 37312 37321 37304 37313 37314 37305 37306
    Human Gene Mutation Database (HGMD): TNKS

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    Disorders / Diseases
    for TNKS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TNKS for disorders           About GeneDecksing

    OMIM gene information: 603303    OMIM disorders: --

    20/21 diseases for TNKS (see all 21):    About MalaCards
    cornelia de lange syndrome    congenital diaphragmatic hernia    hernia    herpes simplex
    fanconi's anemia    tongue cancer    diphtheria    cerebrovascular disease
    cerebral atherosclerosis    lung cancer    hepatitis b    anemia
    atherosclerosis    pulmonary disease    cerebritis    gastric cancer
    breast cancer    hepatitis    schizophrenia    malaria

    1 disease from the University of Copenhagen DISEASES database for TNKS:
    Cerebral atherosclerosis

    3 Novoseek disease relationships for TNKS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 31 9 18369822 (3), 15652747 (2), 17617028 (1), 16421589 (1) (see all 5)
    leukemia 0 1 10753188 (1)
    tumors 0 7 17617028 (5), 15498272 (2)

    Human Genome Epidemiology (HuGE) Navigator: TNKS (13 documents)

    Export disorders for TNKS gene to outside databases

    Publications
    for TNKS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNKS gene, integrated from 9 sources (see all 104):
    (articles sorted by number of sources associating them with TNKS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. (PubMed id 9822378)1, 2, 3 Smith S.... de Lange T. (1998)
    2. NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis. (PubMed id 16076287)1, 2, 9 Chang W....Smith S. (2005)
    3. Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. (PubMed id 11739745)1, 2, 9 Cook B.D.... Smith S. (2002)
    4. Zinc binding catalytic domain of human tankyrase 1. (PubMed id 18436240)1, 2, 9 Lehtio L....Weigelt J. (2008)
    5. Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation. (PubMed id 22864114)1, 2 Ozaki Y.... Inaba T. (2012)
    6. RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. (PubMed id 21478859)1, 2 Zhang Y.... Cong F. (2011)
    7. Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling. (PubMed id 21799911)1, 2 Callow M.G....Costa M. (2011)
    8. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. (PubMed id 19759537)1, 2 Huang S.M....Cong F. (2009)
    9. POT1 as a terminal transducer of TRF1 telomere length control. (PubMed id 12768206)1, 2 Loayza D. and De Lange T. (2003)
    10. Tankyrase is a Golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles. (PubMed id 10988299)1, 2 Chi N.-W. and Lodish H.F. (2000)

    External Searches for TNKS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TNKS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8658 HGNC: 11941 AceView: TNKS Ensembl:ENSG00000173273 euGenes: HUgn8658
    ECgene: TNKS H-InvDB: TNKS

    Other Databases showing TNKS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TNKS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNKS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TNKS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TNKS gene:
    Search GeneIP for patents involving TNKS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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