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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNK2 Gene

protein-coding   GIFtS: 62
GCID: GC03M195590

Tyrosine Kinase, Non-Receptor, 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tyrosine Kinase, Non-Receptor, 21 2     ACK2 5
ACK12 3 5     Activated CDC42 Kinase 12
Activated Cdc42-Associated Kinase 11 2     Activated P21cdc42Hs Kinase2
Tyrosine Kinase Non-Receptor Protein 22 3     p21cdc42Hs2
ACK-12 3     EC 2.7.11.13
EC 2.7.10.23 8     EC 2.7.108

External Ids:    HGNC: 192971   Entrez Gene: 101882   Ensembl: ENSG000000619387   OMIM: 6069945   UniProtKB: Q079123   

Export aliases for TNK2 gene to outside databases

Previous GC identifers: GC03M197080 GC03M192870


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNK2 Gene:
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and
GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique
sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism
that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation
signal transduction pathway. Several alternatively spliced transcript variants have been identified from this
gene, but the full-length nature of only two transcript variants has been determined. (provided by RefSeq, Jul
2008)

GeneCards Summary for TNK2 Gene: 
TNK2 (tyrosine kinase, non-receptor, 2) is a protein-coding gene. Diseases associated with TNK2 include ductal carcinoma in situ, and wiskott-aldrich syndrome, and among its related super-pathways are G-protein signaling Regulation of RAC1 activity and Focal adhesion. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is SYK.

UniProtKB/Swiss-Prot: ACK1_HUMAN, Q07912
Function: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading
and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and
nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated
endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and
mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR
at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell
migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in
brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and
'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on
'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF)
toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on
cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively
regulating pro-survival factors such as AKT1 and AR

Gene Wiki entry for TNK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_029928.13  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNK2 gene promoter:
         AREB6   Pax-3   NF-1/L   NF-1   FOXC1   p300   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

TNK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNK2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M195590:  view genomic region     (about GC identifiers)

Start:
195,590,235 bp from pter      End:
195,638,816 bp from pter
Size:
48,582 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACK1_HUMAN, Q07912 (See protein sequence)
Recommended Name: Activated CDC42 kinase 1  
Size: 1038 amino acids; 114569 Da
Cofactor: Magnesium
Subunit: Interacts with NEDD4 (via WW3 domain). NEDD4L and EGF promote association with NEDD4 (By similarity).
Homodimer. Interacts with AR, CDC42, WWASL and WWOX. Interacts with CSPG4 (activated). Interacts with MERTK
(activated); stimulates autophosphorylation. May interact (phosphorylated) with HSP90AB1; maintains kinase
activity. Interacts with NPHP1. Interacts with SNX9 (via SH3 domain). Interacts with SRC (via SH2 and SH3
domain). Interacts with EGFR, and this interaction is dependent on EGF stimulation and kinase activity of EGFR.
Interacts (via kinase domain) with AKT1. Part of a collagen stimulated complex involved in cell migration
composed of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with BCAR1/p130cas via SH3 domains. Forms complexes
with GRB2 and numerous receptor tyrosine kinases (RTK) including LTK, AXL or PDGFRL, in which GRB2 promotes RTK
recruitment by TNK2
Subcellular location: Cell membrane. Nucleus. Endosome. Cell junction, adherens junction (By similarity).
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated
vesicle. Membrane, clathrin-coated pit. Note=The Tyr-284 phosphorylated form is found both in the membrane and
nucleus. Co-localizes with EGFR on endosomes. Nuclear translocation is CDC42-dependent
Sequence caution: Sequence=AAH08884.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice
sites;
6/10 PDB 3D structures from and Proteopedia for TNK2 (see all 10):
1CF4 (3D)        1U46 (3D)        1U4D (3D)        1U54 (3D)        3EQP (3D)        3EQR (3D)    
Secondary accessions: Q6ZMQ0 Q8N6U7 Q96H59
Alternative splicing: 3 isoforms:  Q07912-1   Q07912-2   Q07912-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNK2: NX_Q07912

Explore proteomics data for TNK2 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylation regulates kinase activity. Phosphorylation on Tyr-518 is required for interaction with SRC and
    is observed during association with clathrin-coated pits
  • UniProtKB: Polyubiquitinated by NEDD4 and NEDD4L. Degradation can be induced by EGF and is lysosome-dependent (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q07912

  • 4/13 DME Specific Peptides for TNK2 (Q07912) (see all 13)
     FGVVRRG  GERLPRP  KVPFAWC  RDLAARN 

    TNK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNK2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001010938.1  NP_005772.3  

    ENSEMBL proteins: 
     ENSP00000398614   ENSP00000371341   ENSP00000329425   ENSP00000392546   ENSP00000395588  
     ENSP00000390435   ENSP00000415126   ENSP00000392253   ENSP00000409462   ENSP00000393707  
     ENSP00000395154   ENSP00000390088   ENSP00000376201   ENSP00000323216  

    Human Recombinant Protein Products for TNK2: 
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    Novus Biologicals TNK2 Proteins
    Novus Biologicals TNK2 Lysates
    Sino Biological Recombinant Protein for TNK2
    Sino Biological Cell Lysate for TNK2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNK2 

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005768endosome ISS--
    GO:0005886plasma membrane IDA--
    GO:0005905coated pit IDA--

    TNK2 for ontologies           About GeneDecksing



    TNK2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TNK2
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    Cell Signaling Technology (CST) Antibodies for TNK2  (Ack)
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    Abcam antibodies for TNK2
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    LSBio Antibodies in human, mouse, rat for TNK2 

    Assay Products for TNK2: 
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    Cloud-Clone Corp. ELISAs for TNK2 
    Cloud-Clone Corp. CLIAs for TNK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: tyrosine kinase, non-receptor, 2 
    Ack family

    5/9 InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR021619 Inhibitor_Mig-6

    Graphical View of Domain Structure for InterPro Entry Q07912

    ProtoNet protein and cluster: Q07912

    3 Blocks protein domains:
    IPB000449 Ubiquitin-associated domain
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: ACK1_HUMAN, Q07912
    Domain: The EBD (EGFR-binding domain) domain is necessary for interaction with EGFR (By similarity)
    Domain: The SAM-like domain is necessary for NEDD4-mediated ubiquitination. Promotes membrane localization and
    dimerization to allow for autophosphorylation
    Domain: The UBA domain binds both poly- and mono-ubiquitin
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 1 CRIB domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 1 UBA domain


    TNK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACK1_HUMAN, Q07912
    Function: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading
    and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and
    nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated
    endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and
    mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR
    at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell
    migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in
    brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and
    'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on
    'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF)
    toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on
    cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively
    regulating pro-survival factors such as AKT1 and AR
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by AIM-100 (4-amino-5,6-biaryl-furo[2,3-d]pyrimidine), which suppresses activating
    phosphorylation at Tyr-284. Repressed by dasatinib

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102 EC 2.7.11.11

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004712protein serine/threonine/tyrosine kinase activity IDA16257963
    GO:0004713protein tyrosine kinase activity IDA18993068
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
         
    TNK2 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for TNK2:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased apoptosis 
     Increased circadian period len  Increased gamma-H2AX phosphory  Increases Tamoxifen sensitivit 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNK2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNK2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNK2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNK2
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TNK2 (see all 18):
    hsa-miR-875-3p hsa-miR-330-5p hsa-miR-149 hsa-miR-326 hsa-miR-3121-3p hsa-miR-1299 hsa-miR-3155b hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidTNK2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    GenScript: all cDNA clones in your preferred vector (see all 2): TNK2 (NM_001010938)
    Sino Biological Human cDNA Clone for TNK2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNK2 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of RAC1 activity0.88
    2Focal Adhesion
    Focal Adhesion0.64
    3G-protein signaling Regulation of CDC42 activity
    G-protein signaling Regulation of CDC42 activity1.00
    4CDC42 signaling events
    CDC42 signaling events0.34
    5Tyrosine Kinases / Adaptors
    Tyrosine Kinases / Adaptors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for TNK2
        G-protein signaling Regulation of CDC42 activity
    G-protein signaling Regulation of RAC1 activity


    1 Cell Signaling Technology (CST) Pathway for TNK2
        Tyrosine Kinases / Adaptors

    2 GeneGo (Thomson Reuters) Pathways for TNK2
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of CDC42 activity

    4 BioSystems Pathways for TNK2
        Focal Adhesion
    EGFR1 Signaling Pathway
    G13 Signaling Pathway
    CDC42 signaling events




    TNK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for TNK2 (Q079121, 2, 3 ENSP000003713414) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCAR1P569452, 3, ENSP000001623304MINT-7104409 MINT-7104436 MINT-7104364 MINT-7104381 MINT-7104396 I2D: score=1 STRING: ENSP00000162330
    SNX9Q9Y5X12, 3, ENSP000003760244MINT-62874 MINT-62879 MINT-62873 MINT-62880 I2D: score=3 STRING: ENSP00000376024
    CLTCQ006102, 3, ENSP000002691224MINT-7983409 MINT-62881 I2D: score=4 STRING: ENSP00000269122
    ITFG2Q969R82, 3, ENSP000002287994MINT-64707 I2D: score=2 STRING: ENSP00000228799
    CRKP461082, 3, ENSP000003005744MINT-7104372 I2D: score=1 STRING: ENSP00000300574
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006897endocytosis IEA--
    GO:0007166cell surface receptor signaling pathway TAS--
    GO:0007264small GTPase mediated signal transduction TAS8497321
    GO:0016310phosphorylation IDA--

    TNK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNK2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNK2 (ACK1)

    3 HMDB Compounds for TNK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 DrugBank Compounds for TNK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17139284 17016423
    Debromohymenialdisine-- --target--17139284 17016423

    2 Novoseek inferred chemical compound relationships for TNK2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 65.8 61 16288044 (7), 16777958 (5), 14506255 (4), 17494760 (3) (see all 22)
    serine 12.8 2 16257963 (2)

    Search CenterWatch for drugs/clinical trials and news about TNK2 / ACK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNK2 gene (2 alternative transcripts): 
    NM_001010938.1  NM_005781.4  

    Unigene Cluster for TNK2:

    Tyrosine kinase, non-receptor, 2
    Hs.518513  [show with all ESTs]
    Unigene Representative Sequence: AB209338
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000416152 ENST00000381916(uc003fvt.1 uc010hzw.1) ENST00000333602(uc003fvu.1)
    ENST00000420716(uc003fvq.1) ENST00000428187(uc003fvs.1) ENST00000495247
    ENST00000464041 ENST00000439230 ENST00000481865(uc003fvv.1) ENST00000424563
    ENST00000478623 ENST00000411741 ENST00000489628 ENST00000478715 ENST00000468680
    ENST00000486523 ENST00000438207 ENST00000430929
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNK2

    Additional mRNA sequence: 

    AB209338.1 AK126712.1 AK127455.1 AK131539.1 AK225786.1 AK309332.1 BC008884.2 BC020389.1 
    BC028164.1 L13738.2 

    24 DOTS entries:

    DT.91875210  DT.97780847  DT.101983760  DT.101983759  DT.99967159  DT.40208268  DT.120927703  DT.91695164 
    DT.100751739  DT.100751737  DT.120927389  DT.95241216  DT.95355848  DT.97818466  DT.100009087  DT.120927805 
    DT.120927670  DT.120927822  DT.75189040  DT.95217433  DT.95241213  DT.95241214  DT.95241217  DT.99935113 

    24/181 AceView cDNA sequences (see all 181):

    BU183396 AK131539 H02127 BM972633 BG742978 BI905791 BF058375 BU579620 
    BC020389 BQ066273 AI873679 BC020395 BG912405 CF242783 BC008884 CD675007 
    AW072953 C02015 BC028164 AI950554 AI440501 AI439274 AW206140 AI859326 

    GeneLoc Exon Structure

    5/24 Alternative Splicing Database (ASD) splice patterns (SP) for TNK2 (see all 24)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17a ·
    SP1:                                      -     -     -     -     -     -                       -                                         -                     
    SP2:                                                        -     -                             -                                                               
    SP3:                                                                    -                       -                                         -                     
    SP4:        -     -     -     -     -     -     -     -     -     -     -                       -                                         -                     
    SP5:                                -     -     -     -     -     -     -                       -                                                               

    ExUns: 17b · 17c ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c · 23d · 23e · 23f ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^
    SP1:                                -     -     -     -     -                                                                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for TNK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TNK2 Expression
    About this image


    See TNK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNK2

    SOURCE GeneReport for Unigene cluster: Hs.518513

    UniProtKB/Swiss-Prot: ACK1_HUMAN, Q07912
    Tissue specificity: The Tyr-284 phosphorylated form shows a significant increase in expression in breast cancers
    during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal
    carcinoma (IDC) and lymph node metastatic (LNMM) stages. It also shows a significant increase in expression in
    prostate cancers during the progressive stages

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TNK2 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnk21 , 5 tyrosine kinase, non-receptor, 21, 5 87.59(n)1
    94.53(a)1
      16 (23.16 cM)5
    517891  NM_016788.31  NP_058068.21 
     326438745 
    chicken
    (Gallus gallus)
    Aves TNK21 tyrosine kinase, non-receptor, 2 75.81(n)
    76.08(a)
      431014  XM_428565.3  XP_428565.3 
    lizard
    (Anolis carolinensis)
    Reptilia TNK26
    Uncharacterized protein
    76(a)
    1 ↔ 1
    AAWZ02040347(2529-5436)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480610082   -- 77.5(n)    48061008 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5591191 activated CDC42 kinase 1-like 67.74(n)
    68.18(a)
      559119  XM_001919003.3  XP_001919038.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ack6
    Ack
    30(a)
    1 → many
    3L(4108186-4114157)
    worm
    (Caenorhabditis elegans)
    Secernentea kin-251 Protein KIN-25 43.89(n)
    34.05(a)
      181756  NM_078383.3  NP_510784.2 


    ENSEMBL Gene Tree for TNK2 (if available)
    TreeFam Gene Tree for TNK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNK2 gene
    SYK2  TNK12  JAK32  JAK22  TYK22  ERBB42  JAK12  ERBB32  
    PTK22  ERBB22  ZAP702  EGFR2  PTK2B2  
    18/68 SIMAP similar genes for TNK2 using alignment to 10 protein entries:     ACK1_HUMAN (see all proteins) (see all similar genes):
    SRC    PTK2    FRK    EPHA2    FYN    HCK
    ERBB2    EGFR    ERBB4    EPHA5    JAK2    FES
    EPHA3    EPHA6    EZR-ROS1    FGR    LRIG3(NM_001136051)-ROS1    LRIG3(NM_153377)-ROS1

    TNK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1435 SNPs in TNK2 are shown (see all 1435)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0327924
    A lung adenocarcinoma sample4--see VAR_0327922 R L mis40--------
    VAR_0327974
    An ovarian endometrioid cancer sample4--see VAR_0327972 E K mis40--------
    VAR_0327944
    An ovarian mucinous carcinoma sample4--see VAR_0327942 R Q mis40--------
    VAR_0327984
    A gastric adenocarcinoma sample4--see VAR_0327982 M I mis40--------
    rs67737021,2
    C,F,A,H--195589762(+) CAGGCG/ATCTCT 2 -- ds500118Minor allele frequency- A:0.12EA NS NA CSA WA 2116
    rs23446541,2
    C,F,A,H--195589770(-) CCCAGC/TGCAGA 2 -- ds500124Minor allele frequency- T:0.26EA NS NA WA CSA 2124
    rs738911591,2
    C,F--195589790(+) GGCCGC/TGGTGG 2 -- ds50016Minor allele frequency- T:0.11WA NA CSA EA 364
    rs1879762271,2
    C--195589816(+) TTCACC/TGTACA 2 -- ds50010--------
    rs1402404561,2
    --195589832(+) CAGTGC/TCTTTT 2 -- ds50010--------
    rs1452388711,2
    --195590185(+) TTGGGA/GCCTGG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for TNK2 (195590235 - 195638816 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/30 variations for TNK2 (see all 30):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726528CNV Deletion23290073
    esv2726527CNV Deletion23290073
    esv2726526CNV Deletion23290073
    esv2726538CNV Deletion23290073
    esv2726533CNV Deletion23290073
    esv2726532CNV Deletion23290073
    dgv835e201CNV Deletion23290073
    esv2726539CNV Deletion23290073
    dgv834e201CNV Deletion23290073
    esv2726531CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606994    OMIM disorders: --

    13 diseases for TNK2:    About MalaCards
    ductal carcinoma in situ    wiskott-aldrich syndrome    prostate cancer, progression of    prostate cancer
    prostatitis    hepatitis c    gastric cancer    esophagitis
    melanoma    hepatitis    breast cancer    leukemia
    neuronitis


    TNK2 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for TNK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 54.4 2 9422512 (1), 16257963 (1)
    prostate cancer 20 5 17494760 (2), 18190847 (2), 16288044 (1)
    cancer 3.92 6 20432460 (2), 15886301 (1), 19815557 (1)
    shock 0 2 8647288 (2)
    tumors 0 11 16288044 (3), 17494760 (2), 18190847 (2), 19144635 (1) (see all 5)

    Human Genome Epidemiology (HuGE) Navigator: TNK2 (2 documents)

    Export disorders for TNK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNK2 gene, integrated from 9 sources (see all 96):
    (articles sorted by number of sources associating them with TNK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. (PubMed id 8497321)1, 2, 3 Manser E.... Lim L. (1993)
    2. Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck. (PubMed id 14506255)1, 3, 9 Yokoyama N. and Miller W.T. (2003)
    3. Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2. (PubMed id 19144635)1, 2, 9 Chan W....Manser E. (2009)
    4. Cytoplasmic ACK1 interaction with multiple receptor t yrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signali ng. (PubMed id 19815557)1, 2, 9 Pao-Chun L....Manser E. (2009)
    5. Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox. (PubMed id 16288044)1, 2, 9 Mahajan N.P.... Earp H.S. (2005)
    6. Dysregulation of Ack1 inhibits down-regulation of the EGF receptor. (PubMed id 18262180)1, 2, 9 Grovdal L.M....Stang E. (2008)
    7. SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1. (PubMed id 16137687)1, 2, 9 Yeow-Fong L....Manser E. (2005)
    8. Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase. (PubMed id 16257963)1, 2, 9 Yokoyama N....Miller W.T. (2005)
    9. Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation. (PubMed id 17494760)1, 2, 9 Mahajan N.P....Whang Y.E. (2007)
    10. Shepherding AKT and androgen receptor by Ack1 tyrosin e kinase. (PubMed id 20432460)1, 2, 9 Mahajan K. and Mahajan N.P. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10188 HGNC: 19297 AceView: ACK1 Ensembl:ENSG00000061938 euGenes: HUgn10188
    ECgene: TNK2 H-InvDB: TNK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNK2 Pharmacogenomics, SNPs, Pathways
    CGP resequencing studieshttp://www.sanger.ac.uk/perl/genetics/CGP/cgp_viewer?action=gene&ln=ACK1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNK2 gene:
    Search GeneIP for patents involving TNK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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