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Aliases for TNK2 Gene

Aliases for TNK2 Gene

  • Tyrosine Kinase Non Receptor 2 2 3
  • Tyrosine Kinase, Non-Receptor, 2 2 3 5
  • Tyrosine Kinase Non-Receptor Protein 2 3 4
  • Activated Cdc42-Associated Kinase 1 2 3
  • EC 2.7.10.2 4 63
  • ACK-1 3 4
  • ACK1 3 4
  • Activated P21cdc42Hs Kinase 3
  • EC 2.7.11.1 4
  • P21cdc42Hs 3
  • EC 2.7.10 63
  • ACK 3

External Ids for TNK2 Gene

Previous GeneCards Identifiers for TNK2 Gene

  • GC03M197080
  • GC03M195590
  • GC03M192870

Summaries for TNK2 Gene

Entrez Gene Summary for TNK2 Gene

  • This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNK2 Gene

TNK2 (Tyrosine Kinase Non Receptor 2) is a Protein Coding gene. Diseases associated with TNK2 include infantile-onset mesial temporal lobe epilepsy with severe cognitive regression and subacute myeloid leukemia. Among its related pathways are EGFR1 Signaling Pathway and G-protein signaling_Regulation of CDC42 activity. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is TYK2.

UniProtKB/Swiss-Prot for TNK2 Gene

  • Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on Tyr-176. Phosphorylates AR on Tyr-267 and Tyr-363 thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on Tyr-287. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.

Gene Wiki entry for TNK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNK2 Gene

Genomics for TNK2 Gene

Regulatory Elements for TNK2 Gene

Genomic Location for TNK2 Gene

Chromosome:
3
Start:
195,863,364 bp from pter
End:
195,911,945 bp from pter
Size:
48,582 bases
Orientation:
Minus strand

Genomic View for TNK2 Gene

Genes around TNK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNK2 Gene

Proteins for TNK2 Gene

  • Protein details for TNK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07912-ACK1_HUMAN
    Recommended name:
    Activated CDC42 kinase 1
    Protein Accession:
    Q07912
    Secondary Accessions:
    • Q6ZMQ0
    • Q8N6U7
    • Q96H59

    Protein attributes for TNK2 Gene

    Size:
    1038 amino acids
    Molecular mass:
    114569 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with NEDD4 (via WW3 domain). NEDD4L and EGF promote association with NEDD4 (By similarity). Homodimer. Interacts with AR, CDC42, WWASL and WWOX. Interacts with CSPG4 (activated). Interacts with MERTK (activated); stimulates autophosphorylation. May interact (phosphorylated) with HSP90AB1; maintains kinase activity. Interacts with NPHP1. Interacts with SNX9 (via SH3 domain). Interacts with SRC (via SH2 and SH3 domain). Interacts with EGFR, and this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts (via kinase domain) with AKT1. Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with BCAR1/p130cas via SH3 domains. Forms complexes with GRB2 and numerous receptor tyrosine kinases (RTK) including LTK, AXL or PDGFRL, in which GRB2 promotes RTK recruitment by TNK2.
    SequenceCaution:
    • Sequence=AAH08884.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNK2 Gene

    Alternative splice isoforms for TNK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNK2 Gene

Proteomics data for TNK2 Gene at MOPED

Post-translational modifications for TNK2 Gene

  • Autophosphorylation regulates kinase activity. Phosphorylation on Tyr-518 is required for interaction with SRC and is observed during association with clathrin-coated pits.
  • Polyubiquitinated by NEDD4 and NEDD4L. Degradation can be induced by EGF and is lysosome-dependent (By similarity).
  • Ubiquitination at Lys 1037
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TNK2 (Ack)

Domains & Families for TNK2 Gene

Gene Families for TNK2 Gene

Suggested Antigen Peptide Sequences for TNK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q07912

UniProtKB/Swiss-Prot:

ACK1_HUMAN :
  • The EBD (EGFR-binding domain) domain is necessary for interaction with EGFR.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
Domain:
  • The EBD (EGFR-binding domain) domain is necessary for interaction with EGFR.
  • The SAM-like domain is necessary for NEDD4-mediated ubiquitination. Promotes membrane localization and dimerization to allow for autophosphorylation.
  • The UBA domain binds both poly- and mono-ubiquitin.
  • Contains 1 CRIB domain.
  • Contains 1 protein kinase domain.
  • Contains 1 SH3 domain.
  • Contains 1 UBA domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with TNK2: view

Function for TNK2 Gene

Molecular function for TNK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by AIM-100 (4-amino-5,6-biaryl-furo[2,3-d]pyrimidine), which suppresses activating phosphorylation at Tyr-284. Repressed by dasatinib.
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on Tyr-176. Phosphorylates AR on Tyr-267 and Tyr-363 thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on Tyr-287. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.

Enzyme Numbers (IUBMB) for TNK2 Gene

Gene Ontology (GO) - Molecular Function for TNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004712 protein serine/threonine/tyrosine kinase activity IDA 16257963
GO:0004713 protein tyrosine kinase activity IEA,IDA 18993068
GO:0005154 epidermal growth factor receptor binding IDA 20086093
genes like me logo Genes that share ontologies with TNK2: view
genes like me logo Genes that share phenotypes with TNK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TNK2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNK2 Gene

Localization for TNK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNK2 Gene

Cell membrane. Nucleus. Endosome. Cell junction, adherens junction. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle. Membrane, clathrin-coated pit. Note=The Tyr-284 phosphorylated form is found both in the membrane and nucleus. Colocalizes with EGFR on endosomes. Nuclear translocation is CDC42-dependent.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNK2 Gene COMPARTMENTS Subcellular localization image for TNK2 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4
endosome 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome ISS --
GO:0016020 membrane IDA 19946888
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with TNK2: view

Pathways & Interactions for TNK2 Gene

genes like me logo Genes that share pathways with TNK2: view

Pathways by source for TNK2 Gene

SIGNOR curated interactions for TNK2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0016310 phosphorylation IDA 20333297
GO:0030154 cell differentiation IBA --
GO:0034260 negative regulation of GTPase activity TAS 8497321
GO:0038083 peptidyl-tyrosine autophosphorylation IBA --
genes like me logo Genes that share ontologies with TNK2: view

Drugs & Compounds for TNK2 Gene

(5) Drugs for TNK2 Gene - From: HMDB, DrugBank, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra Target 0
Debromohymenialdisine Experimental Pharma Target 0
Magnesium Nutra 0

(1) Additional Compounds for TNK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TNK2: view

Transcripts for TNK2 Gene

Unigene Clusters for TNK2 Gene

Tyrosine kinase, non-receptor, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNK2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17a ·
SP1: - - - - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - -
SP7: -
SP8: - - -
SP9:
SP10: - - - - - - -
SP11: - - - - -
SP12: - - - - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22: - - - - - - - - - - - - - - - - - - - - -
SP23:
SP24:

ExUns: 17b · 17c ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c · 23d · 23e · 23f ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^
SP1: - - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - - - -
SP9: - - - - - - -
SP10:
SP11:
SP12:
SP13:
SP14: - - -
SP15:
SP16:
SP17: - - - - - -
SP18: - - - -
SP19: - - -
SP20:
SP21:
SP22: - - - - - - - - - -
SP23:
SP24:

ExUns: 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -
SP21:
SP22:
SP23:
SP24:

Relevant External Links for TNK2 Gene

GeneLoc Exon Structure for
TNK2
ECgene alternative splicing isoforms for
TNK2

Expression for TNK2 Gene

mRNA expression in normal human tissues for TNK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNK2 Gene

This gene is overexpressed in Plasma (42.1), Lung (12.6), and Pancreatic juice (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNK2 Gene



SOURCE GeneReport for Unigene cluster for TNK2 Gene Hs.518513

mRNA Expression by UniProt/SwissProt for TNK2 Gene

Q07912-ACK1_HUMAN
Tissue specificity: The Tyr-284 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages. It also shows a significant increase in expression in prostate cancers during the progressive stages.
genes like me logo Genes that share expression patterns with TNK2: view

Protein tissue co-expression partners for TNK2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TNK2 Gene

Orthologs for TNK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TNK2 35
  • 91.19 (n)
  • 94.89 (a)
BT.64988 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNK2 36
  • 92 (a)
OneToOne
TNK2 35
  • 90.57 (n)
  • 94.74 (a)
mouse
(Mus musculus)
Mammalia Tnk2 16
Tnk2 35
  • 87.7 (n)
  • 94.61 (a)
Tnk2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNK2 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnk2 35
  • 88.05 (n)
  • 93.93 (a)
chicken
(Gallus gallus)
Aves TNK2 35
  • 75.03 (n)
  • 75 (a)
TNK2 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9615 35
tnk2 35
  • 65.98 (n)
  • 70.12 (a)
zebrafish
(Danio rerio)
Actinopterygii CT476804.2 36
  • 58 (a)
OneToMany
tnk2a 36
  • 58 (a)
OneToMany
tnk2b 36
  • 62 (a)
OneToMany
LOC559119 35
  • 67.53 (n)
  • 67.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ack 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sid-3 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToMany
Species with no ortholog for TNK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNK2 Gene

ENSEMBL:
Gene Tree for TNK2 (if available)
TreeFam:
Gene Tree for TNK2 (if available)

Paralogs for TNK2 Gene

Paralogs for TNK2 Gene

genes like me logo Genes that share paralogs with TNK2: view

Variants for TNK2 Gene

Sequence variations from dbSNP and Humsavar for TNK2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_032792 A lung adenocarcinoma sample
rs56036945 - 195,886,999(+) TGCGT(C/T)TGCAC upstream-variant-2KB, reference, missense, utr-variant-5-prime
VAR_032794 An ovarian mucinous carcinoma sample
rs3747673 - 195,884,973(-) CCTTC(C/T)GGAAG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs56161912 - 195,884,813(+) TCACC(A/G)TCTTC upstream-variant-2KB, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TNK2 Gene

Variant ID Type Subtype PubMed ID
dgv1549e1 CNV Complex 17122850
nsv428430 CNV Gain+Loss 18775914
dgv1551e1 CNV Complex 17122850
dgv1552e1 CNV Complex 17122850
dgv1553e1 CNV Complex 17122850
nsv471621 CNV Gain+Loss 15918152
dgv5369n71 CNV Loss 21882294
esv2751988 CNV Gain 17911159
nsv822410 CNV Loss 20364138
dgv1556e1 CNV Complex 17122850
dgv5370n71 CNV Loss 21882294
nsv878167 CNV Gain 21882294
dgv5371n71 CNV Loss 21882294
nsv878169 CNV Loss 21882294
esv2726526 CNV Deletion 23290073
esv2726527 CNV Deletion 23290073
esv2726528 CNV Deletion 23290073
esv28378 CNV Gain 19812545
esv2726530 CNV Deletion 23290073
esv1214939 CNV Deletion 17803354
esv2726531 CNV Deletion 23290073
esv2726532 CNV Deletion 23290073
esv2726533 CNV Deletion 23290073
dgv834e201 CNV Deletion 23290073
dgv835e201 CNV Deletion 23290073
esv2726538 CNV Deletion 23290073
nsv829827 CNV Gain+Loss 17160897
esv2726539 CNV Deletion 23290073
nsv469518 CNV Complex 16826518
esv22999 CNV Loss 19812545

Variation tolerance for TNK2 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.46; 71.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNK2 Gene

HapMap Linkage Disequilibrium report
TNK2
Human Gene Mutation Database (HGMD)
TNK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNK2 Gene

Disorders for TNK2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TNK2 Gene - From: Orphanet and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search TNK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TNK2

Human Genome Epidemiology (HuGE) Navigator
TNK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNK2
genes like me logo Genes that share disorders with TNK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNK2 Gene

Publications for TNK2 Gene

  1. A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. (PMID: 8497321) Manser E. … Lim L. (Nature 1993) 2 3 4 67
  2. Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck. (PMID: 14506255) Yokoyama N. … Miller W.T. (J. Biol. Chem. 2003) 2 3 23
  3. HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. (PMID: 20086093) Lin Q. … Yang W. (Mol. Cell. Biol. 2010) 3 23
  4. Shepherding AKT and androgen receptor by Ack1 tyrosine kinase. (PMID: 20432460) Mahajan K. … Mahajan N.P. (J. Cell. Physiol. 2010) 3 23
  5. Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2. (PMID: 19144635) Chan W. … Manser E. (J. Biol. Chem. 2009) 3 23

Products for TNK2 Gene

Sources for TNK2 Gene

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