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TNK1 Gene

protein-coding   GIFtS: 64
GCID: GC17P007284

Tyrosine Kinase, Non-Receptor, 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tyrosine Kinase, Non-Receptor, 11 2
CD38 Negative Kinase 12 3
EC 2.7.10.23 8
Non-Receptor Tyrosine-Protein Kinase TNK12
EC 2.7.108

External Ids:    HGNC: 119401   Entrez Gene: 87112   Ensembl: ENSG000001742927   OMIM: 6080765   UniProtKB: Q134703   

Export aliases for TNK1 gene to outside databases

Previous GC identifers: GC17P007682 GC17P008014 GC17P007227 GC17P007484 GC17P007225 GC17P007178


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNK1 Gene:
The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are
important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival,
and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus
may function in signaling pathways utilized broadly during fetal development, and more selectively in adult
tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to
develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for TNK1 Gene:
TNK1 (tyrosine kinase, non-receptor, 1) is a protein-coding gene. Diseases associated with TNK1 include pancreatic cancer, and alzheimer's disease. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity and signal transducer activity. An important paralog of this gene is SYK.

UniProtKB/Swiss-Prot: TNK1_HUMAN, Q13470
Function: Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative
regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal
development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could
specifically be involved in phospholipid signal transduction




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNK1 gene promoter:
         Max1   AML1a   GCNF   Pax-2   AP-4   Pax-2a   NF-kappaB   GCNF-1   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNK1 promoter sequence
   Search Chromatin IP Primers for TNK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

TNK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNK1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007284:  view genomic region     (about GC identifiers)

Start:
7,283,853 bp from pter      End:
7,293,093 bp from pter
Size:
9,241 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TNK1_HUMAN, Q13470 (See protein sequence)
Recommended Name: Non-receptor tyrosine-protein kinase TNK1  
Size: 666 amino acids; 72468 Da
Subunit: Interacts with the SH3 domain of PLCG1 via its Pro-rich domain
Secondary accessions: O95364 Q8IYI4
Alternative splicing: 2 isoforms:  Q13470-1   Q13470-2   (No experimental confirmation available. Contains a phosphoserine at position 411)

Explore the universe of human proteins at neXtProt for TNK1: NX_Q13470

Explore proteomics data for TNK1 at MOPED

Post-translational modifications: 

  • Autophosphorylated on tyrosine residues1
  • Ubiquitination2 at Lys141
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for TNK1 (Q13470)
     PADRPSF  HRDLATRN  WMFGVTLWEMF 


    See TNK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001238831.1  NP_003976.2  

    ENSEMBL proteins: 
     ENSP00000458834   ENSP00000459799   ENSP00000475164   ENSP00000466590   ENSP00000460146  
     ENSP00000312309  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: tyrosine kinase, non-receptor, 1
    Ack family

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q13470

    ProtoNet protein and cluster: Q13470

    1 Blocks protein domain: IPB008266 Tyrosine protein kinase

    UniProtKB/Swiss-Prot: TNK1_HUMAN, Q13470
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH3 domain


    TNK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNK1_HUMAN, Q13470
    Function: Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative
    regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal
    development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could
    specifically be involved in phospholipid signal transduction
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for TNK1:
    intracellular tyrosine kinase,expressed in all cord blood,bone marrow and adult blood populations and in adult
    prostate,testis,ovary,small intestine,colon

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity IDA10873601
    GO:0004715non-membrane spanning protein tyrosine kinase activity NAS10873601
    GO:0004871signal transducer activity TAS8632913
    GO:0005515protein binding IPI10873601
         
    TNK1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TNK1:
     Synthetic lethal with gemcitab 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tnk1):
     endocrine/exocrine gland  integument  tumorigenesis 

    TNK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tnk1tm1Sksuf for TNK1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNK1
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    hsa-miR-297 hsa-miR-3171 hsa-miR-3714
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNK1_HUMAN, Q13470: Cytoplasm. Membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10873601
    GO:0005829cytosol IEA--
    GO:0016020membrane IDA10873601
    GO:0030054cell junction IDA--

    TNK1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNK1 About    
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal Adhesion0.65
    2Tyrosine Kinases / Adaptors
    Tyrosine Kinases / Adaptors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TNK1
        Tyrosine Kinases / Adaptors

    1 BioSystems Pathway for TNK1
        Focal Adhesion



    TNK1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TNK1
    Interactions:

        GeneGlobe Interaction Network for TNK1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for TNK1 (Q134702, 3 ENSP000003123094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3975686 I2D: score=2 
    PLCG1P191743, ENSP000002440074I2D: score=3 STRING: ENSP00000244007
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS8632913
    GO:0007165signal transduction TAS8632913
    GO:0018108peptidyl-tyrosine phosphorylation TAS8632913
    GO:0030308negative regulation of cell growth IEA--
    GO:0046580negative regulation of Ras protein signal transduction IEA--

    TNK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNK1

    2 HMDB Compounds for TNK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TNK1 gene (2 alternative transcripts): 
    NM_001251902.1  NM_003985.4  

    Unigene Cluster for TNK1:

    Tyrosine kinase, non-receptor, 1
    Hs.203420  [show with all ESTs]
    Unigene Representative Sequence: NM_001251902
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570896(uc002ggi.4 uc002ggj.4 uc010cmf.3) ENST00000576812
    ENST00000575268 ENST00000574794 ENST00000576207 ENST00000577009 ENST00000576136
    ENST00000576716 ENST00000311668
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TNK1:
    hsa-miR-297 hsa-miR-3171 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidTNK1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK225403.1 AK310684.1 BC035782.1 HQ696959.1 U43408.1 

    5 DOTS entries:

    DT.109741  DT.95364265  DT.120936171  DT.65284902  DT.75101854 

    Selected AceView cDNA sequences (see all 47):

    BM790022 AU099255 CR623896 AI095668 AI912928 AI625357 BE646234 CA440241 
    AI224174 BF844063 BI908132 AA862013 BX448526 BC035782 BX281082 BM971510 
    AW771324 AA480582 AI090080 AA618592 AA026922 CK822675 AI139480 BX448527 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TNK1 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                -                                                                                                                     
    SP2:                                -                                                                                                                     
    SP3:                                                                                                  -                                                   
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for TNK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAACAGCCA
    TNK1 Expression
    About this image


    TNK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Ovary (Reproductive System)
    TNK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.203420

    UniProtKB/Swiss-Prot: TNK1_HUMAN, Q13470
    Tissue specificity: Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in
    several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower
    levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or
    brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TNK1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnk11 , 5 tyrosine kinase, non-receptor, 11, 5 81.57(n)1
    83.03(a)1
      11 (42.90 cM)5
    838131  NM_031880.31  NP_114086.31 
     698510055 
    zebrafish
    (Danio rerio)
    Actinopterygii tnk16
    tyrosine kinase, non-receptor, 1
    35(a)
    1 ↔ 1
    7(27671370-27690652) ENSDARG00000069433
    fruit fly
    (Drosophila melanogaster)
    Insecta Ack6
    Ack
    21(a)
    1 → many
    3L(4108186-4114157)
    worm
    (Caenorhabditis elegans)
    Secernentea sid-36
    Protein SID-3, isoform a (sid-3) mRNA, complete cd...
    17(a)
    1 → many
    X(17186140-17193293) WBGene00002207


    ENSEMBL Gene Tree for TNK1 (if available)
    TreeFam Gene Tree for TNK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNK1 gene
    SYK2  JAK32  JAK22  TNK22  TYK22  ERBB42  JAK12  ERBB32  
    PTK22  ERBB22  ZAP702  EGFR2  PTK2B2  
    9 SIMAP similar genes for TNK1 using alignment to 4 protein entries:     TNK1_HUMAN (see all proteins):
    TNK2    SRC    EPHA2    ERBB4    FGR    ABL1
    FES    CDK4    DKFZp686M05208

    TNK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNK1 (see all 298)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0418644
    A lung adenocarcinoma sample4--see VAR_0418642 R K mis40--------
    rs1509166461,2
    --7282388(+) TTTTTG/TTGTGT 2 -- us2k10--------
    rs124516351,2
    C,H--7282390(+) tttttG/Ttgtgt 2 -- us2k10--------
    rs1931454921,2
    --7282415(+) GAGACA/GGGGTT 2 -- us2k10--------
    rs1849192601,2
    --7282471(+) CCACCC/TGCCTC 2 -- us2k10--------
    rs3715659261,2
    C--7282489(+) CAAAG-/TGCTAG 2 -- us2k10--------
    rs2016423721,2
    C--7282542(+) TTTCA-/TATGAG
            
    TATAA
    2 -- us2k10--------
    rs1123385741,2
    F--7282670(+) TGAATG/ATATCA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1455901151,2
    --7282865(+) TTCATA/GCATAC 2 -- us2k10--------
    rs1459111731,2
    C--7282994(+) ACAAC-/AATGAGGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TNK1 (7283853 - 7293093 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TNK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    nsv470575CNV Loss18288195
    nsv907645CNV Loss21882294
    dgv3053n71CNV Loss21882294
    nsv907644CNV Loss21882294
    nsv457659CNV Loss19166990
    nsv523672CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608076    OMIM disorders: --

    6 diseases for TNK1:    
    About MalaCards
    pancreatic cancer    alzheimer's disease    hodgkin's lymphoma    pancreatitis
    prostatitis    leukemia


    TNK1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TNK1
    Human Genome Epidemiology (HuGE) Navigator: TNK1 (6 documents)

    Export disorders for TNK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNK1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with TNK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells. (PubMed id 8632913)1, 2, 3, 9 Hoehn G.T.... Civin C.I. (Oncogene 1996)
    2. Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study. (PubMed id 20413850)1, 4 Laumet G....Lambert J.C. (J. Alzheimers Dis. 2010)
    3. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. (PubMed id 20574532)1, 4 Shulman J.M....De Jager P.L. (PLoS ONE 2010)
    4. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. (PubMed id 20534741)1, 4 Corneveaux J.J....Huentelman M.J. (Hum. Mol. Genet. 2010)
    5. Assessment of Alzheimer's disease case-control associations using family-based methods. (PubMed id 18830724)1, 4 Schjeide B.M....Bertram L. (Neurogenetics 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1. (PubMed id 10873601)1, 2 Felschow D.M.... Hoehn G.T. (Biochem. Biophys. Res. Commun. 2000)
    8. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    9. High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells. (PubMed id 21536687)1 Henderson M.C....Azorsa D.O. (Mol. Cancer Res. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 8711 HGNC: 11940 AceView: TNK1 Ensembl:ENSG00000174292 euGenes: HUgn8711
    ECgene: TNK1 H-InvDB: TNK1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TNK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TNK1 gene:
    Search GeneIP for patents involving TNK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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