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Aliases for TNK1 Gene

Aliases for TNK1 Gene

  • Tyrosine Kinase, Non-Receptor, 1 2 3
  • EC 2.7.10.2 4 63
  • CD38 Negative Kinase 1 4
  • EC 2.7.10 63

External Ids for TNK1 Gene

Previous GeneCards Identifiers for TNK1 Gene

  • GC17P007682
  • GC17P008014
  • GC17P007227
  • GC17P007484
  • GC17P007225
  • GC17P007284
  • GC17P007178

Summaries for TNK1 Gene

Entrez Gene Summary for TNK1 Gene

  • The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TNK1 Gene

TNK1 (Tyrosine Kinase, Non-Receptor, 1) is a Protein Coding gene. Among its related pathways are Tyrosine Kinases / Adaptors and Focal adhesion. GO annotations related to this gene include signal transducer activity and non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is TYK2.

UniProtKB/Swiss-Prot for TNK1 Gene

  • Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNK1 Gene

Genomics for TNK1 Gene

Regulatory Elements for TNK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNK1 Gene

Start:
7,380,534 bp from pter
End:
7,389,774 bp from pter
Size:
9,241 bases
Orientation:
Plus strand

Genomic View for TNK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNK1 Gene

Proteins for TNK1 Gene

  • Protein details for TNK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13470-TNK1_HUMAN
    Recommended name:
    Non-receptor tyrosine-protein kinase TNK1
    Protein Accession:
    Q13470
    Secondary Accessions:
    • O95364
    • Q8IYI4

    Protein attributes for TNK1 Gene

    Size:
    666 amino acids
    Molecular mass:
    72468 Da
    Quaternary structure:
    • Interacts with the SH3 domain of PLCG1 via its Pro-rich domain.

    Alternative splice isoforms for TNK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNK1 Gene

Proteomics data for TNK1 Gene at MOPED

Selected DME Specific Peptides for TNK1 Gene

Post-translational modifications for TNK1 Gene

Other Protein References for TNK1 Gene

Domains for TNK1 Gene

Gene Families for TNK1 Gene

Suggested Antigen Peptide Sequences for TNK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13470

UniProtKB/Swiss-Prot:

TNK1_HUMAN :
  • Q13470
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with TNK1: view

Function for TNK1 Gene

Molecular function for TNK1 Gene

GENATLAS Biochemistry: intracellular tyrosine kinase,expressed in all cord blood,bone marrow and adult blood populations and in adult prostate,testis,ovary,small intestine,colon
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.

Enzyme Numbers (IUBMB) for TNK1 Gene

Gene Ontology (GO) - Molecular Function for TNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity IDA 10873601
GO:0004715 non-membrane spanning protein tyrosine kinase activity NAS 10873601
GO:0004871 signal transducer activity TAS 8632913
GO:0005515 protein binding IPI 10873601
genes like me logo Genes that share ontologies with TNK1: view

Phenotypes for TNK1 Gene

genes like me logo Genes that share phenotypes with TNK1: view

Animal Models for TNK1 Gene

MGI Knock Outs for TNK1:

Animal Model Products

CRISPR Products

miRNA for TNK1 Gene

miRTarBase miRNAs that target TNK1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNK1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for TNK1 Gene

Localization for TNK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNK1 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNK1 Gene COMPARTMENTS Subcellular localization image for TNK1 gene
Compartment Confidence
plasma membrane 3
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10873601
GO:0005829 cytosol IEA --
GO:0016020 membrane IDA 10873601
GO:0030054 cell junction --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with TNK1: view

Pathways for TNK1 Gene

genes like me logo Genes that share pathways with TNK1: view

Pathways by source for TNK1 Gene

1 Cell Signaling Technology pathway for TNK1 Gene
1 BioSystems pathway for TNK1 Gene

Interacting Proteins for TNK1 Gene

Selected Interacting proteins: Q13470-TNK1_HUMAN for TNK1 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for TNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 8632913
GO:0007165 signal transduction --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0016477 cell migration IBA --
GO:0018108 peptidyl-tyrosine phosphorylation --
genes like me logo Genes that share ontologies with TNK1: view

Compounds for TNK1 Gene

(2) HMDB Compounds for TNK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with TNK1: view

Transcripts for TNK1 Gene

Unigene Clusters for TNK1 Gene

Tyrosine kinase, non-receptor, 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNK1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TNK1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNK1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:

Relevant External Links for TNK1 Gene

GeneLoc Exon Structure for
TNK1
ECgene alternative splicing isoforms for
TNK1

Expression for TNK1 Gene

mRNA expression in normal human tissues for TNK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TNK1 Gene

SOURCE GeneReport for Unigene cluster for TNK1 Gene Hs.203420

mRNA Expression by UniProt/SwissProt for TNK1 Gene

Q13470-TNK1_HUMAN
Tissue specificity: Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.
genes like me logo Genes that share expressions with TNK1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TNK1 Gene

Orthologs for TNK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNK1 35
  • 99.24 (n)
  • 98.79 (a)
TNK1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNK1 35
  • 85.95 (n)
  • 84.58 (a)
TNK1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNK1 35
  • 86.13 (n)
  • 85.33 (a)
TNK1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnk1 35
  • 81.57 (n)
  • 83.03 (a)
Tnk1 16
Tnk1 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnk1 35
  • 81.06 (n)
  • 82.58 (a)
zebrafish
(Danio rerio)
Actinopterygii tnk1 36
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ack 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sid-3 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for TNK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TNK1 Gene

ENSEMBL:
Gene Tree for TNK1 (if available)
TreeFam:
Gene Tree for TNK1 (if available)

Paralogs for TNK1 Gene

Paralogs for TNK1 Gene

Selected SIMAP similar genes for TNK1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TNK1: view

Variants for TNK1 Gene

Sequence variations from dbSNP and Humsavar for TNK1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs968580 -- 7,387,502(+) ACCAG(C/T)CCTTC intron-variant
rs1003476 -- 7,386,013(-) gtaga(A/G)tgtag intron-variant
rs1003477 -- 7,385,941(-) catgt(G/T)acttt intron-variant
rs1065020 -- 7,383,470(+) TGCCC(A/T)CGGAC missense, reference
rs1065021 -- 7,388,594(+) GGCCC(A/G)AAAGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TNK1 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
dgv3053n71 CNV Loss 21882294
nsv907644 CNV Loss 21882294
nsv523672 CNV Loss 19592680
nsv907645 CNV Loss 21882294
nsv470575 CNV Loss 18288195

Relevant External Links for TNK1 Gene

HapMap Linkage Disequilibrium report
TNK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNK1 Gene

Disorders for TNK1 Gene

Relevant External Links for TNK1

Genetic Association Database (GAD)
TNK1
Human Genome Epidemiology (HuGE) Navigator
TNK1
genes like me logo Genes that share disorders with TNK1: view

No data available for UniProtKB/Swiss-Prot for TNK1 Gene

Publications for TNK1 Gene

  1. Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells. (PMID: 8632913) Hoehn G.T. … Civin C.I. (Oncogene 1996) 2 3 4 23
  2. Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1. (PMID: 10873601) Felschow D.M. … Hoehn G.T. (Biochem. Biophys. Res. Commun. 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Assessment of Alzheimer's disease case-control associations using family-based methods. (PMID: 18830724) Schjeide B.M. … Bertram L. (Neurogenetics 2009) 3 48
  5. Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study. (PMID: 20413850) Laumet G. … Lambert J.C. (J. Alzheimers Dis. 2010) 3 48

Products for TNK1 Gene

  • Addgene plasmids for TNK1

Sources for TNK1 Gene

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