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Aliases for TNK1 Gene

Aliases for TNK1 Gene

  • Tyrosine Kinase Non Receptor 1 2 3 5
  • EC 2.7.10.2 4 56
  • Tyrosine Kinase, Non-Receptor, 1 2
  • CD38 Negative Kinase 1 4
  • EC 2.7.10 56

External Ids for TNK1 Gene

Previous GeneCards Identifiers for TNK1 Gene

  • GC17P007682
  • GC17P008014
  • GC17P007227
  • GC17P007484
  • GC17P007225
  • GC17P007284
  • GC17P007178

Summaries for TNK1 Gene

Entrez Gene Summary for TNK1 Gene

  • The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TNK1 Gene

TNK1 (Tyrosine Kinase Non Receptor 1) is a Protein Coding gene. Among its related pathways are Tyrosine Kinases / Adaptors and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TNK2.

UniProtKB/Swiss-Prot for TNK1 Gene

  • Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.

Additional gene information for TNK1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNK1 Gene

Genomics for TNK1 Gene

GeneHancer (GH) Regulatory Elements for TNK1 Gene

Promoters and enhancers for TNK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I007380 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 556.9 +0.6 637 1.4 DRAP1 ELF3 KLF1 RB1 SAP130 ARID4B SIN3A TEAD3 PHF20 POLR2A TNK1 CHRNB1 KCTD11 TMEM95 TMEM256 NLGN2 SPEM1 SPEM2 ACAP1 NEURL4
GH17I007474 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.8 +100.1 100055 12.5 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC POLR2A ZBTB4 SLC35G6 DVL2 PFAS SNORD10 CTC1 WRAP53 SNORA48 CNTROB
GH17I006654 Enhancer 1.1 Ensembl ENCODE dbSUPER 7.4 -724.3 -724333 4 CTCF MZF1 SIN3A ZIC2 RFX5 POLR2A ZNF600 ZBTB20 EZH2 RFX1 ENSG00000261996 ALOX15P1 ENSG00000274114 MIR4520-1 MIR4520-2 KIAA0753 TNK1 C17orf100
GH17I007383 Promoter/Enhancer 1 Ensembl ENCODE 6.2 +3.8 3794 1.4 USF1 POLR2A ETS1 EZH2 TMEM95 KCTD11 NLGN2 SPEM1 SPEM2 ACAP1 NEURL4 ENSG00000224647 EIF5A CHRNB1
GH17I006660 Enhancer 0.9 Ensembl dbSUPER 5.7 -719.5 -719533 1.6 HDGF BMI1 BATF ZFHX2 POLR2A ATF7 ETV6 ZNF600 IKZF2 RUNX3 ENSG00000261996 TXNDC17 SLC13A5 PITPNM3 BCL6B TNK1 ALOX15P1 ENSG00000274114 C17orf100 GC17P006673
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNK1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNK1 gene promoter:

Genomic Locations for TNK1 Gene

Genomic Locations for TNK1 Gene
chr17:7,380,534-7,389,774
(GRCh38/hg38)
Size:
9,241 bases
Orientation:
Plus strand
chr17:7,283,853-7,293,093
(GRCh37/hg19)

Genomic View for TNK1 Gene

Genes around TNK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNK1 Gene

Proteins for TNK1 Gene

  • Protein details for TNK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13470-TNK1_HUMAN
    Recommended name:
    Non-receptor tyrosine-protein kinase TNK1
    Protein Accession:
    Q13470
    Secondary Accessions:
    • O95364
    • Q8IYI4

    Protein attributes for TNK1 Gene

    Size:
    666 amino acids
    Molecular mass:
    72468 Da
    Quaternary structure:
    • Interacts with the SH3 domain of PLCG1 via its Pro-rich domain.

    Alternative splice isoforms for TNK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNK1 Gene

Selected DME Specific Peptides for TNK1 Gene

Q13470:
  • HRDLATRN
  • PADRPSF
  • WMFGVTLWEMF

Post-translational modifications for TNK1 Gene

Domains & Families for TNK1 Gene

Gene Families for TNK1 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TNK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13470

UniProtKB/Swiss-Prot:

TNK1_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with TNK1: view

Function for TNK1 Gene

Molecular function for TNK1 Gene

GENATLAS Biochemistry:
intracellular tyrosine kinase,expressed in all cord blood,bone marrow and adult blood populations and in adult prostate,testis,ovary,small intestine,colon
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.

Enzyme Numbers (IUBMB) for TNK1 Gene

Phenotypes From GWAS Catalog for TNK1 Gene

Gene Ontology (GO) - Molecular Function for TNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IDA 10873601
GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS,NAS 10873601
GO:0004871 signal transducer activity TAS 8632913
GO:0005102 receptor binding IBA --
genes like me logo Genes that share ontologies with TNK1: view
genes like me logo Genes that share phenotypes with TNK1: view

Animal Models for TNK1 Gene

MGI Knock Outs for TNK1:

miRNA for TNK1 Gene

miRTarBase miRNAs that target TNK1

Clone Products

  • Addgene plasmids for TNK1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNK1 Gene

Localization for TNK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNK1 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNK1 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 10873601
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA,IDA 10873601
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with TNK1: view

Pathways & Interactions for TNK1 Gene

genes like me logo Genes that share pathways with TNK1: view

Pathways by source for TNK1 Gene

1 Cell Signaling Technology pathway for TNK1 Gene
1 BioSystems pathway for TNK1 Gene

Interacting Proteins for TNK1 Gene

Gene Ontology (GO) - Biological Process for TNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 8632913
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0016310 phosphorylation IEA --
GO:0016477 cell migration IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with TNK1: view

No data available for SIGNOR curated interactions for TNK1 Gene

Drugs & Compounds for TNK1 Gene

(1) Drugs for TNK1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for TNK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TNK1: view

Transcripts for TNK1 Gene

Unigene Clusters for TNK1 Gene

Tyrosine kinase, non-receptor, 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for TNK1

Alternative Splicing Database (ASD) splice patterns (SP) for TNK1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:

Relevant External Links for TNK1 Gene

GeneLoc Exon Structure for
TNK1
ECgene alternative splicing isoforms for
TNK1

Expression for TNK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNK1 Gene

This gene is overexpressed in Lung (59.2) and Urine (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNK1 Gene



Protein tissue co-expression partners for TNK1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNK1 Gene:

TNK1

SOURCE GeneReport for Unigene cluster for TNK1 Gene:

Hs.203420

mRNA Expression by UniProt/SwissProt for TNK1 Gene:

Q13470-TNK1_HUMAN
Tissue specificity: Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.

Evidence on tissue expression from TISSUES for TNK1 Gene

  • Liver(4)
genes like me logo Genes that share expression patterns with TNK1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNK1 Gene

Orthologs for TNK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNK1 33 34
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia TNK1 33 34
  • 86.13 (n)
cow
(Bos Taurus)
Mammalia TNK1 33 34
  • 85.95 (n)
mouse
(Mus musculus)
Mammalia Tnk1 33 16 34
  • 81.57 (n)
rat
(Rattus norvegicus)
Mammalia Tnk1 33
  • 81.06 (n)
zebrafish
(Danio rerio)
Actinopterygii tnk1 34
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ack 34
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sid-3 34
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
OneToMany
Species where no ortholog for TNK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TNK1 Gene

ENSEMBL:
Gene Tree for TNK1 (if available)
TreeFam:
Gene Tree for TNK1 (if available)

Paralogs for TNK1 Gene

Paralogs for TNK1 Gene

(9) SIMAP similar genes for TNK1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TNK1: view

Variants for TNK1 Gene

Sequence variations from dbSNP and Humsavar for TNK1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
VAR_041864 A lung adenocarcinoma sample p.Arg339Lys
rs1000533068 -- 7,388,340(+) G/A intron_variant
rs1000547127 -- 7,387,289(+) G/A intron_variant
rs1000562666 -- 7,386,051(+) T/G intron_variant
rs1000641794 -- 7,387,011(+) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for TNK1 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv457659 CNV loss 19166990
nsv470575 CNV loss 18288195
nsv523672 CNV loss 19592680
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for TNK1 Gene

Residual Variation Intolerance Score: 88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNK1 Gene

Human Gene Mutation Database (HGMD)
TNK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNK1 Gene

Disorders for TNK1 Gene

Additional Disease Information for TNK1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TNK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNK1 Gene

Publications for TNK1 Gene

  1. Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells. (PMID: 8632913) Hoehn GT … Civin CI (Oncogene 1996) 2 3 4 22 58
  2. Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study. (PMID: 20413850) Laumet G … Lambert JC (Journal of Alzheimer's disease : JAD 2010) 3 44 58
  3. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. (PMID: 20574532) Shulman JM … De Jager PL (PloS one 2010) 3 44 58
  4. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. (PMID: 20534741) Corneveaux JJ … Huentelman MJ (Human molecular genetics 2010) 3 44 58
  5. Assessment of Alzheimer's disease case-control associations using family-based methods. (PMID: 18830724) Schjeide BM … Bertram L (Neurogenetics 2009) 3 44 58

Products for TNK1 Gene

  • Addgene plasmids for TNK1

Sources for TNK1 Gene

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