Aliases for TNK1 Gene
External Ids for TNK1 Gene
The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for TNK1 Gene
TNK1 (Tyrosine Kinase, Non-Receptor, 1) is a Protein Coding gene. Among its related pathways are Tyrosine Kinases / Adaptors and Focal adhesion. GO annotations related to this gene include signal transducer activity and non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is TYK2.
UniProtKB/Swiss-Prot for TNK1 Gene
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.