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Aliases for TNIP3 Gene

Aliases for TNIP3 Gene

  • TNFAIP3 Interacting Protein 3 2 3
  • A20-Binding Inhibitor Of NF-Kappa-B Activation 3 3 4
  • Listeria-Induced Gene Protein 3 4
  • ABIN-3 3 4
  • LIND 3 4
  • TNFAIP3-Interacting Protein 3 Beta 3
  • TNFAIP3-Interacting Protein 3 3
  • Listeria Induced 3
  • ABIN-3 Beta 3
  • TNIP3 Beta 3
  • ABIN3 4

External Ids for TNIP3 Gene

Previous GeneCards Identifiers for TNIP3 Gene

  • GC04M122332
  • GC04M122445
  • GC04M122511
  • GC04M122410
  • GC04M122272
  • GC04M122052
  • GC04M117779

Summaries for TNIP3 Gene

GeneCards Summary for TNIP3 Gene

TNIP3 (TNFAIP3 Interacting Protein 3) is a Protein Coding gene. GO annotations related to this gene include polyubiquitin binding. An important paralog of this gene is TNIP1.

UniProtKB/Swiss-Prot for TNIP3 Gene

  • Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNIP3 Gene

Genomics for TNIP3 Gene

Regulatory Elements for TNIP3 Gene

Genomic Location for TNIP3 Gene

Start:
121,131,408 bp from pter
End:
121,227,466 bp from pter
Size:
96,059 bases
Orientation:
Minus strand

Genomic View for TNIP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNIP3 Gene

Proteins for TNIP3 Gene

  • Protein details for TNIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KP6-TNIP3_HUMAN
    Recommended name:
    TNFAIP3-interacting protein 3
    Protein Accession:
    Q96KP6
    Secondary Accessions:
    • A1A574
    • A8K2Z4
    • B4DVF5
    • B4E023
    • Q96PQ3
    • Q9H780

    Protein attributes for TNIP3 Gene

    Size:
    325 amino acids
    Molecular mass:
    38943 Da
    Quaternary structure:
    • Interacts with TNFAIP3. Interacts with polyubiquitin.
    SequenceCaution:
    • Sequence=BAB15018.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15018.1; Type=Frameshift; Positions=272; Evidence={ECO:0000305}; Sequence=CAC85929.1; Type=Frameshift; Positions=272; Evidence={ECO:0000305};

    Alternative splice isoforms for TNIP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNIP3 Gene

Proteomics data for TNIP3 Gene at MOPED

Post-translational modifications for TNIP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNIP3 Gene

Antibody Products

No data available for DME Specific Peptides for TNIP3 Gene

Domains for TNIP3 Gene

Protein Domains for TNIP3 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNIP3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TNIP3 Gene

Function for TNIP3 Gene

Molecular function for TNIP3 Gene

UniProtKB/Swiss-Prot Function:
Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
UniProtKB/Swiss-Prot Induction:
By Listeria infection. Expression is slightly down-regulated by dexamethasone and slightly up-regulated by IL-10. Strongly induced mRNA and protein expression by lipopolysaccharide.

Gene Ontology (GO) - Molecular Function for TNIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0031593 polyubiquitin binding IDA 18212736
genes like me logo Genes that share ontologies with TNIP3: view

Phenotypes for TNIP3 Gene

MGI mutant phenotypes for TNIP3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with TNIP3: view

Animal Models for TNIP3 Gene

MGI Knock Outs for TNIP3:

Animal Model Products

miRNA for TNIP3 Gene

miRTarBase miRNAs that target TNIP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNIP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TNIP3 Gene

Localization for TNIP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNIP3 Gene COMPARTMENTS Subcellular localization image for TNIP3 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TNIP3 Gene

Pathways for TNIP3 Gene

SuperPathways for TNIP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TNIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002756 MyD88-independent toll-like receptor signaling pathway IDA 17088249
GO:0006954 inflammatory response IEA --
GO:0034142 toll-like receptor 4 signaling pathway IDA 17088249
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IDA 17088249
GO:0071222 cellular response to lipopolysaccharide IDA 17088249
genes like me logo Genes that share ontologies with TNIP3: view

No data available for Pathways by source for TNIP3 Gene

Transcripts for TNIP3 Gene

Unigene Clusters for TNIP3 Gene

TNFAIP3 interacting protein 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNIP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNIP3 Gene

No ASD Table

Relevant External Links for TNIP3 Gene

GeneLoc Exon Structure for
TNIP3
ECgene alternative splicing isoforms for
TNIP3

Expression for TNIP3 Gene

mRNA expression in normal human tissues for TNIP3 Gene

mRNA differential expression in normal tissues according to GTEx for TNIP3 Gene

This gene is overexpressed in Lung (6.6).

Protein differential expression in normal tissues for TNIP3 Gene

This gene is overexpressed in Pancreatic juice (67.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNIP3 Gene

SOURCE GeneReport for Unigene cluster for TNIP3 Gene Hs.208206

mRNA Expression by UniProt/SwissProt for TNIP3 Gene

Q96KP6-TNIP3_HUMAN
Tissue specificity: Highly expressed in lung, lymph node, thymus and fetal liver. Expressed at lower levels in bone marrow, brain, kidney, spleen, leukocytes and tonsils. Could be detected in heart, salivary gland, adrenal gland, pancreas, ovary and fetal brain. High levels detected in liver, colon, small intestine, muscle, stomach, testis, placenta, thyroid, uterus, prostate, skin and PBL.
genes like me logo Genes that share expressions with TNIP3: view

Expression partners for TNIP3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TNIP3 Gene

Orthologs for TNIP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNIP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100298642 35
  • 84.57 (n)
  • 75.34 (a)
TNIP3 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNIP3 35
  • 85.86 (n)
  • 77.45 (a)
TNIP3 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnip3 35
  • 75.19 (n)
  • 62.5 (a)
Tnip3 16
Tnip3 36
  • 50 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNIP3 35
  • 99.47 (n)
  • 99.47 (a)
TNIP3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnip3 35
  • 71.27 (n)
  • 60.67 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia TNIP3 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNIP3 35
  • 58.59 (n)
  • 48.75 (a)
TNIP3 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNIP3 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnip3 35
  • 59.47 (n)
  • 47.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
OneToMany
Species with no ortholog for TNIP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNIP3 Gene

ENSEMBL:
Gene Tree for TNIP3 (if available)
TreeFam:
Gene Tree for TNIP3 (if available)

Paralogs for TNIP3 Gene

Paralogs for TNIP3 Gene

Selected SIMAP similar genes for TNIP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TNIP3: view

Variants for TNIP3 Gene

Sequence variations from dbSNP and Humsavar for TNIP3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs896621 -- 121,200,428(-) CCCCT(C/G)AGCCT intron-variant
rs896623 -- 121,212,944(+) GTCAC(C/T)CCATA intron-variant
rs921551 -- 121,189,820(-) AGCCC(A/G)GGTTT intron-variant
rs959268 -- 121,153,308(+) CAAAA(A/C)TACAG intron-variant
rs998327 -- 121,162,957(-) ACTGT(C/T)TCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNIP3 Gene

Variant ID Type Subtype PubMed ID
nsv879859 CNV Gain 21882294
nsv4492 CNV Insertion 18451855
nsv879860 CNV Loss 21882294
nsv879861 CNV Gain 21882294

Relevant External Links for TNIP3 Gene

HapMap Linkage Disequilibrium report
TNIP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNIP3 Gene

Disorders for TNIP3 Gene

Relevant External Links for TNIP3

Genetic Association Database (GAD)
TNIP3
Human Genome Epidemiology (HuGE) Navigator
TNIP3

No disorders were found for TNIP3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TNIP3 Gene

Publications for TNIP3 Gene

  1. LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF- kappaB activation. (PMID: 17088249) Wullaert A. … Beyaert R. (J. Biol. Chem. 2007) 3 4 23
  2. Two novel genes FIND and LIND differentially expressed in deactivated and Listeria-infected human macrophages. (PMID: 11345586) Staege H. … Schaffner A. (Immunogenetics 2001) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. ABIN-3: a molecular basis for species divergence in interleukin-10- induced anti-inflammatory actions. (PMID: 17485448) Weaver B.K. … Schreiber R.D. (Mol. Cell. Biol. 2007) 3 23
  5. Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappaB. (PMID: 18081698) Verstrepen L. … Beyaert R. (J. Cell. Mol. Med. 2008) 3 23

Products for TNIP3 Gene

Sources for TNIP3 Gene

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