Aliases for TNIP3 Gene
External Ids for TNIP3 Gene
Previous GeneCards Identifiers for TNIP3 Gene
GeneCards Summary for TNIP3 Gene
TNIP3 (TNFAIP3 Interacting Protein 3) is a Protein Coding gene. Among its related pathways are Ovarian tumor domain proteases and Metabolism of proteins. GO annotations related to this gene include polyubiquitin binding. An important paralog of this gene is TNIP1.
UniProtKB/Swiss-Prot for TNIP3 Gene
Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.