TNIP3 Gene
protein-coding GIFtS: 45
GCID: GC04M122052
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TNFAIP3 interacting protein 3
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Aliases
for TNIP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TNFAIP3 Interacting Protein 31 2 | | ABIN-3 Beta2 | | ABIN-31 2 3 | | Listeria Induced2 | | LIND1 2 3 | | TNFAIP3-Interacting Protein 32 | | Listeria-Induced Gene Protein2 3 | | TNFAIP3-Interacting Protein 3 Beta2 | | A20-Binding Inhibitor Of NF-Kappa-B Activation 32 3 | | TNIP3 Beta2 | | FLJ211621 | | ABIN33 |
Export aliases for TNIP3 gene to outside databasesPrevious GC identifers: GC04M122332 GC04M122445 GC04M122511 GC04M122410 GC04M122272 GC04M117779 |
Summaries
for TNIP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TNIP3_HUMAN, Q96KP6Function: Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor,Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibitsNF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream ofIKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding
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Genomic Views
for TNIP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TNIP3 gene promoter:
C/EBPbeta AML1a Nkx6-1 Pbx1a Nkx2-2 FOXD3 FOXL1 Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TNIP3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNIP3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q27 Ensembl cytogenetic band: 4q27 HGNC cytogenetic band: 4q27TNIP3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M122052: view genomic region
(about GC identifiers)
Start:
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122,052,563 bp from pter |
End:
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122,148,621 bp from pter |
Size:
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96,059 bases |
Orientation:
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minus strand |
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Proteins
for TNIP3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TNIP3_HUMAN, Q96KP6 (See
protein sequence)Recommended Name: TNFAIP3-interacting protein 3 Size: 325 amino acids; 38943 Da
Subunit: Interacts with TNFAIP3. Interacts with polyubiquitin
Sequence caution: Sequence=BAB15018.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAB15018.1; Type=Frameshift; Positions=272; Sequence=CAC85929.1; Type=Frameshift; Positions=272;
Secondary accessions: A1A574 A8K2Z4 B4DVF5 B4E023 Q96PQ3 Q9H780Alternative splicing: 3 isoforms: Q96KP6-1 Q96KP6-2 Q96KP6-3 Explore the universe of human proteins at neXtProt for TNIP3: NX_Q96KP6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96KP6
TNIP3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001122315.2 NP_001231693.1 NP_079149.3
ENSEMBL proteins: ENSP00000057513 ENSP00000427106 ENSP00000426613 ENSP00000424284 ENSP00000411817
Human Recombinant Protein Products:
TNIP3 Antibody Products:
Assay Products for TNIP3: |
Protein
Domains /
Families
for TNIP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96KP6 |
Function
for TNIP3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TNIP3_HUMAN, Q96KP6Function: Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor,Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibitsNF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream ofIKBKB. NF-kappa-B inhibition is independent of TNFAIP3 bindingInduction: By Listeria infection. Expression is slightly down-regulated by dexamethasone and slightly up-regulated byIL-10. Strongly induced mRNA and protein expression by lipopolysaccharide
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for TNIP3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNIP3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNIP3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
TNIP3 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Tnip3tm1Rds for TNIP3
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Tnip3):
TNIP3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TNIP3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNIP3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/19 Interacting proteins for TNIP3 (Q96KP63 ENSP000000575134) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
TNIP3 for ontologies About GeneDecksing
|
Drugs & Compounds
for TNIP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TNIP3
Search CenterWatch for drugs/clinical trials and news about TNIP3
|
Transcripts
for TNIP3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TNIP3 gene (3 alternative transcripts): NM_001128843.2 NM_001244764.1 NM_024873.5 Unigene Cluster for TNIP3: TNFAIP3 interacting protein 3 Hs.208206 [show with all ESTs]Unigene Representative Sequence: NM_0012447648 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000057513(uc010ing.3) ENST00000507879 ENST00000509841 ENST00000511909
ENST00000515605 ENST00000515036 ENST00000506753(uc010ini.3) ENST00000454328(uc011cgj.2 uc021xrj.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TNIP3 (NM_001128843) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNIP3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNIP3 |
Additional cDNA sequence: AF277289.1 AJ320534.1 AK024815.1 AK290409.1 AK301058.1 AK303192.1 BC128408.1 EF585496.1 5 DOTS entries: DT.40306429 DT.121227880 DT.100703424 DT.121227887 DT.97769159 19 AceView cDNA sequences: CD367219 BP335455 AL046389 AL046388 CA309419 BM723695 AJ320534 BM681878 AK024815 AF277289 BP335192 BP336923 NM_024873 BG217064 AA314767 BG189488 BG203349 BF378709 BF378712
GeneLoc Exon Structure
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Expression
for TNIP3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TNIP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAAGAGAA
About this image
See TNIP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNIP3
SOURCE GeneReport for Unigene cluster: Hs.208206
UniProtKB/Swiss-Prot: TNIP3_HUMAN, Q96KP6Tissue specificity: Highly expressed in lung, lymph node, thymus and fetal liver. Expressed at lower levels in bonemarrow, brain, kidney, spleen, leukocytes and tonsils. Could be detected in heart, salivary gland, adrenal gland,pancreas, ovary and fetal brain. High levels detected in liver, colon, small intestine, muscle, stomach, testis,placenta, thyroid, uterus, prostate, skin and PBL
SABiosciences Custom PCR Arrays for TNIP3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNIP3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNIP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNIP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNIP3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNIP3 |
Orthologs
for TNIP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for TNIP3 gene from 3/11 species (see all 11) About this table
ENSEMBL Gene Tree for TNIP3 (if available)
TreeFam Gene Tree for TNIP3 (if available) |
Paralogs
for TNIP3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TNIP3 gene
- TNIP12
2 SIMAP similar genes for TNIP3 using alignment to 3 protein entries: TNIP3_HUMAN (see all proteins):NAF1 TNIP1
TNIP3 for paralogs About GeneDecksing
|
Genomic Variants
for TNIP3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNIP3 |
|
Disorders
/ Diseases
for TNIP3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TNIP3 for disorders About GeneDecksing
OMIM gene information: 608019
OMIM disorders: --
3  diseases for TNIP3: About MalaCardstonsillitis thyroiditis prostatitis
Human Genome Epidemiology (HuGE) Navigator: TNIP3 (4 documents)
Export disorders for TNIP3 gene to outside databases
|
Publications
for TNIP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TNIP3 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with TNIP3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Two novel genes FIND and LIND differentially expressed in deactivated and Listeria-infected human macrophages. (PubMed id 11345586)1, 2, 3 Staege H.... Schaffner A. (2001)
- LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappaB activation. (PubMed id 17088249)1, 2, 9 Wullaert A....Beyaert R. (2007)
- Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. (PubMed id 18212736)1, 2 Wagner S....Beyaert R. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- ABIN-3: a molecular basis for species divergence in interleukin-10- induced anti-inflammatory actions. (PubMed id 17485448)1, 9 Weaver B.K.... Schreiber R.D. (2007)
- Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappaB. (PubMed id 18081698)1, 9 Verstrepen L....Beyaert R. (2008)
- A pro-inflammatory role for A20 and ABIN family protei ns in human fibroblast-like synoviocytes in rheumatoid arthritis. (PubMed id 22093807)1 Igarashi H....Ishihara K. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
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External Searches for TNIP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TNIP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing TNIP3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TNIP3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TNIP3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TNIP3 gene:
Search GeneIP for patents involving TNIP3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TNIP3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TNIP3 | | OriGene shRNA RFP for TNIP3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNIP3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNIP3 | | | OriGene Protein Over-expression Lysate for TNIP3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TNIP3 | | OriGene 3'-UTR Clone for TNIP3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TNIP3 | | OriGene Custom Protein Services for TNIP3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TNIP3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNIP3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNIP3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNIP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNIP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNIP3 |
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 | | | TNIP3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNIP3 |
|  |  |  | | | | ThermoFisher Antibodies for TNIP3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNIP3 |
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