Aliases for TNIP2 Gene
Aliases for TNIP2 Gene
External Ids for TNIP2 Gene
- HGNC: 19118
- Entrez Gene: 79155
- Ensembl: ENSG00000168884
- OMIM: 610669
- UniProtKB: Q8NFZ5
Previous GeneCards Identifiers for TNIP2 Gene
- GC04M002726
- GC04M002602
- GC04P9I0140
- GC04M002775
- GC04M002780
Summaries for TNIP2 Gene
-
This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]
GeneCards Summary for TNIP2 Gene
TNIP2 (TNFAIP3 Interacting Protein 2) is a Protein Coding gene. Among its related pathways are IL-1 signaling pathway and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include protein kinase binding and polyubiquitin modification-dependent protein binding.
UniProtKB/Swiss-Prot for TNIP2 Gene
-
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNIP2 Gene
Genomics for TNIP2 Gene
GeneHancer (GH) Regulatory Elements for TNIP2 Gene
Promoters and enhancers for TNIP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TNIP2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TNIP2 gene promoter:
Regulatory Element Products
Genomic Locations for TNIP2 Gene
Genomic Locations for TNIP2 Gene
- chr4:2,741,648-2,756,376
- (GRCh38/hg38)
- Size:
- 14,729 bases
- Orientation:
- Minus strand
- chr4:2,743,375-2,758,103
- (GRCh37/hg19)
Genomic View for TNIP2 Gene
Genes around TNIP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p16.3 by Ensembl
- 4p16.3 by Entrez Gene
- 4p16.3 by HGNC
TNIP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TNIP2 Gene
Proteins for TNIP2 Gene
-
Protein details for TNIP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NFZ5-TNIP2_HUMAN
- Recommended name:
- TNFAIP3-interacting protein 2
- Protein Accession:
- Q8NFZ5
- B1AKS4
- B3KTY8
- D3DVQ9
- Q7L5L2
- Q9BQR6
- Q9H682
Protein attributes for TNIP2 Gene
- Size:
- 429 amino acids
- Molecular mass:
- 48700 Da
- Quaternary structure:
-
- Interacts with STK11/LKB1, TNFAIP3, IKBKG, NFKB1, MAP3K8, TEK, RIPK1, CHUK, IKBKB and SMARCD1. Interacts with polyubiquitin.
Protein Expression for TNIP2 Gene
Post-translational modifications for TNIP2 Gene
- In vitro phosphorylated by CHUK.
- Ubiquitinated; undergoes Lys-48-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probably involving deubiquitination.
Other Protein References for TNIP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TNIP2
- Novus Biologicals Antibodies for TNIP2
-
Abcam antibodies for TNIP2
- Invitrogen Antibodies for TNIP2
- GeneTex TNIP2 antibody for TNIP2
-
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Protein Products
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OriGene Purified Proteins for TNIP2
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- Search GeneTex for Proteins for TNIP2
Assay Products
No data available for DME Specific Peptides for TNIP2 Gene
Domains & Families for TNIP2 Gene
Gene Families for TNIP2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TNIP2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TNIP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TNIP2 Gene
Function for TNIP2 Gene
Molecular function for TNIP2 Gene
- UniProtKB/Swiss-Prot Function:
- Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
Phenotypes From GWAS Catalog for TNIP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 12595760 |
| GO:0019901 | protein kinase binding | IDA | 21784860 |
| GO:0031593 | polyubiquitin modification-dependent protein binding | IDA | 18212736 |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0070530 | K63-linked polyubiquitin modification-dependent protein binding | IEA | -- |
Phenotypes for TNIP2 Gene
- MGI mutant phenotypes for TNIP2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TNIP2:
Animal Models for TNIP2 Gene
- MGI Knock Outs for TNIP2:
-
- Tnip2 tm1.1Sley
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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ViGene Biosciences lentiviral particle packaged cDNA for TNIP2 gene
-
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- Search ViGene Biosciences for TNIP2
CRISPR Products
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OriGene CRISPR knockouts for TNIP2
- genomics-online: gRNA clones - Search results for available TNIP2 gene related products
- Applied Biological Materials CRISPR for TNIP2
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNIP2
- GenScript: Design CRISPR guide RNA sequences for TNIP2
miRNA for TNIP2 Gene
- miRTarBase miRNAs that target TNIP2
-
- hsa-mir-218-5p (MIRT024247)
- hsa-mir-24-3p (MIRT030507)
- hsa-mir-4795-3p (MIRT562920)
- hsa-mir-340-5p (MIRT562921)
- hsa-mir-6800-5p (MIRT562922)
- hsa-mir-636 (MIRT562923)
- hsa-mir-5590-3p (MIRT562924)
- hsa-mir-142-5p (MIRT562925)
- hsa-mir-3163 (MIRT562926)
- hsa-mir-648 (MIRT562927)
- hsa-mir-595 (MIRT562928)
- hsa-mir-548l (MIRT562929)
- hsa-mir-8054 (MIRT562930)
- hsa-mir-548k (MIRT562931)
- hsa-mir-548av-5p (MIRT562932)
- hsa-mir-559 (MIRT562933)
- hsa-mir-548y (MIRT562934)
- hsa-mir-548w (MIRT562935)
- hsa-mir-548o-5p (MIRT562936)
- hsa-mir-548j-5p (MIRT562937)
- hsa-mir-548i (MIRT562938)
- hsa-mir-548h-5p (MIRT562939)
- hsa-mir-548d-5p (MIRT562940)
- hsa-mir-548c-5p (MIRT562941)
- hsa-mir-548bb-5p (MIRT562942)
- hsa-mir-548b-5p (MIRT562943)
- hsa-mir-548ay-5p (MIRT562944)
- hsa-mir-548au-5p (MIRT562945)
- hsa-mir-548as-5p (MIRT562946)
- hsa-mir-548ar-5p (MIRT562947)
- hsa-mir-548aq-5p (MIRT562948)
- hsa-mir-548ap-5p (MIRT562949)
- hsa-mir-548am-5p (MIRT562950)
- hsa-mir-548ak (MIRT562951)
- hsa-mir-548ae-5p (MIRT562952)
- hsa-mir-548ad-5p (MIRT562953)
- hsa-mir-548ab (MIRT562954)
- hsa-mir-548a-5p (MIRT562955)
- hsa-mir-548c-3p (MIRT562956)
- hsa-mir-1180-3p (MIRT732717)
miRNA Products
- Search ViGene Biosciences for TNIP2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNIP2
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-
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Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available TNIP2 gene related products
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- Applied Biological Materials Clones for TNIP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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Horizon Cell Lines for TNIP2
-
ViGene Biosciences adenoviral particle packaged cDNA for TNIP2 gene
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ViGene Biosciences lentiviral particle packaged cDNA for TNIP2 gene
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNIP2 Gene
Localization for TNIP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TNIP2 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 1 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005829 | cytosol | TAS,IDA | -- |
Pathways & Interactions for TNIP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Cytokine Signaling in Immune system | ||
| 3 | Innate Immune System |
.61
|
|
| 4 | IL-1 signaling pathway | ||
| 5 | Metabolism of proteins | ||
Pathways by source for TNIP2 Gene
1 BioSystems pathway for TNIP2 Gene
28 Reactome pathways for TNIP2 Gene
1 GeneGo (Thomson Reuters) pathway for TNIP2 Gene
Interacting Proteins for TNIP2 Gene
Selected Interacting proteins:
ENSP00000321203
Q8NFZ5-TNIP2_HUMAN
for TNIP2 Gene via
STRING
IID
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0007249 | I-kappaB kinase/NF-kappaB signaling | IEA | -- |
Transcripts for TNIP2 Gene
mRNA/cDNA for TNIP2 Gene
- (3) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (178) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TNIP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TNIP2
- genomics-online: gRNA clones - Search results for available TNIP2 gene related products
- Applied Biological Materials CRISPR for TNIP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNIP2
- GenScript: Design CRISPR guide RNA sequences for TNIP2
miRNA Products
- Search ViGene Biosciences for TNIP2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNIP2
- Browse OriGene Inhibitory RNA Products For TNIP2
- genomics-online: shRNA clones - Search results for available TNIP2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TNIP2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available TNIP2 gene related products
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- Applied Biological Materials Clones for TNIP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||
| SP7: |
Expression for TNIP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Placenta (15.8), Liver (13.6), Monocytes (9.0), Blymphocyte (8.6), and Peripheral blood mononuclear cells (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNIP2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TNIP2 Gene:
TNIP2SOURCE GeneReport for Unigene cluster for TNIP2 Gene:
Hs.368551mRNA Expression by UniProt/SwissProt for TNIP2 Gene:
Q8NFZ5-TNIP2_HUMAN
Tissue specificity:
Ubiquitously expressed in all tissues examined.
Evidence on tissue expression from TISSUES for TNIP2 Gene
- Liver(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for TNIP2
-
OriGene qPCR primer pairs for TNIP2
- genomics-online: primer clones - Search results for available TNIP2 gene related products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNIP2 Gene
Orthologs for TNIP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TNIP2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TNIP2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tnip2 33 16 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TNIP2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tnip2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | TNIP2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TNIP2 33 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tnip2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC564279 33 |
|
||
| TNIP2 34 |
|
OneToOne |
- Species where no ortholog for TNIP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TNIP2 Gene
Pseudogenes.org Pseudogenes for TNIP2 Gene
No data available for Paralogs for TNIP2 Gene
Variants for TNIP2 Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000097423 | -- | 2,758,349(-) | C/A | upstream_transcript_variant | |
| rs1000189091 | -- | 2,746,858(-) | C/A | intron_variant | |
| rs1000205122 | -- | 2,752,867(-) | G/A | intron_variant | |
| rs1000257257 | -- | 2,752,531(-) | C/T | intron_variant | |
| rs1000335260 | -- | 2,742,047(-) | C/T | 3_prime_UTR_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2189823 | CNV | deletion | 18987734 |
| esv2664337 | CNV | deletion | 23128226 |
| esv2726835 | CNV | deletion | 23290073 |
| nsv1128023 | CNV | deletion | 24896259 |
| nsv470002 | CNV | loss | 18288195 |
| nsv516797 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.53;
85.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TNIP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TNIP2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNIP2 Gene
Disorders for TNIP2 Gene
Additional Disease Information for TNIP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TNIP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNIP2 Gene
Publications for TNIP2 Gene
- ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1. (PMID: 12933576) Tadros A … Brindle NP (Blood 2003) 2 3 4 22 58
- Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2. (PMID: 11390377) Van Huffel S … Beyaert R (The Journal of biological chemistry 2001) 2 3 4 22 58
- The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis. (PMID: 14653779) Liu WK … Chou CK (The Biochemical journal 2004) 3 4 22 58
- ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. (PMID: 15169888) Lang V … Ley SC (Molecular and cellular biology 2004) 3 4 22 58
- An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation. (PMID: 12595760) Liu WK … Su JY (Journal of biomedical science 2003) 3 4 22 58
Products for TNIP2 Gene
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- Invitrogen Antibodies for TNIP2
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- GeneTex TNIP2 antibody for TNIP2
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- ViGene Biosciences adenoviral particle packaged cDNA for TNIP2 gene
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- genomics-online: cdna clones - Search results for available TNIP2 gene related products
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Sources for TNIP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
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