Aliases for TNIP2 Gene
Aliases for TNIP2 Gene
External Ids for TNIP2 Gene
- HGNC: 19118
- Entrez Gene: 79155
- Ensembl: ENSG00000168884
- OMIM: 610669
- UniProtKB: Q8NFZ5
Previous GeneCards Identifiers for TNIP2 Gene
- GC04M002726
- GC04M002602
- GC04P9I0140
- GC04M002775
- GC04M002780
Summaries for TNIP2 Gene
-
This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]
GeneCards Summary for TNIP2 Gene
TNIP2 (TNFAIP3 Interacting Protein 2) is a Protein Coding gene. Among its related pathways are IL-1 signaling pathway and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include protein kinase binding and polyubiquitin modification-dependent protein binding.
UniProtKB/Swiss-Prot for TNIP2 Gene
-
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNIP2 Gene
Genomics for TNIP2 Gene
GeneHancer (GH) Regulatory Elements for TNIP2 Gene
- Top Transcription factor binding sites by QIAGEN in the TNIP2 gene promoter:
Regulatory Element Products
Genomic Locations for TNIP2 Gene
- chr4:2,741,648-2,756,376
- (GRCh38/hg38)
- Size:
- 14,729 bases
- Orientation:
- Minus strand
- chr4:2,743,375-2,758,103
- (GRCh37/hg19)
Genomic View for TNIP2 Gene
- Cytogenetic band:
-
- 4p16.3 by Ensembl
- 4p16.3 by Entrez Gene
- 4p16.3 by HGNC


RefSeq DNA sequence for TNIP2 Gene
Proteins for TNIP2 Gene
-
Protein details for TNIP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NFZ5-TNIP2_HUMAN
- Recommended name:
- TNFAIP3-interacting protein 2
- Protein Accession:
- Q8NFZ5
- B1AKS4
- B3KTY8
- D3DVQ9
- Q7L5L2
- Q9BQR6
- Q9H682
Protein attributes for TNIP2 Gene
- Size:
- 429 amino acids
- Molecular mass:
- 48700 Da
- Quaternary structure:
-
- Interacts with STK11/LKB1, TNFAIP3, IKBKG, NFKB1, MAP3K8, TEK, RIPK1, CHUK, IKBKB and SMARCD1. Interacts with polyubiquitin.
Protein Expression for TNIP2 Gene
Post-translational modifications for TNIP2 Gene
- In vitro phosphorylated by CHUK.
- Ubiquitinated; undergoes Lys-48-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probably involving deubiquitination.
Other Protein References for TNIP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for TNIP2
- Invitrogen Antibodies for TNIP2
- GeneTex TNIP2 antibody for TNIP2
-
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Protein Products
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OriGene Purified Proteins for TNIP2
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- Search GeneTex for Proteins for TNIP2
Assay Products
No data available for DME Specific Peptides for TNIP2 Gene
Domains & Families for TNIP2 Gene
Gene Families for TNIP2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TNIP2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TNIP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TNIP2 Gene
Function for TNIP2 Gene
Molecular function for TNIP2 Gene
- UniProtKB/Swiss-Prot Function:
- Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
Phenotypes From GWAS Catalog for TNIP2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 12595760 |
GO:0019901 | protein kinase binding | IDA | 21784860 |
GO:0031593 | polyubiquitin modification-dependent protein binding | IDA | 18212736 |
GO:0046872 | metal ion binding | IEA | -- |
GO:0070530 | K63-linked polyubiquitin modification-dependent protein binding | IEA | -- |
Phenotypes for TNIP2 Gene
- MGI mutant phenotypes for TNIP2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TNIP2:
Animal Models for TNIP2 Gene
- MGI Knock Outs for TNIP2:
-
- Tnip2 tm1.1Sley
Animal Model Products
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CRISPR Products
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miRNA for TNIP2 Gene
- miRTarBase miRNAs that target TNIP2
-
- hsa-mir-218-5p (MIRT024247)
- hsa-mir-24-3p (MIRT030507)
- hsa-mir-4795-3p (MIRT562920)
- hsa-mir-340-5p (MIRT562921)
- hsa-mir-6800-5p (MIRT562922)
- hsa-mir-636 (MIRT562923)
- hsa-mir-5590-3p (MIRT562924)
- hsa-mir-142-5p (MIRT562925)
- hsa-mir-3163 (MIRT562926)
- hsa-mir-648 (MIRT562927)
- hsa-mir-595 (MIRT562928)
- hsa-mir-548l (MIRT562929)
- hsa-mir-8054 (MIRT562930)
- hsa-mir-548k (MIRT562931)
- hsa-mir-548av-5p (MIRT562932)
- hsa-mir-559 (MIRT562933)
- hsa-mir-548y (MIRT562934)
- hsa-mir-548w (MIRT562935)
- hsa-mir-548o-5p (MIRT562936)
- hsa-mir-548j-5p (MIRT562937)
- hsa-mir-548i (MIRT562938)
- hsa-mir-548h-5p (MIRT562939)
- hsa-mir-548d-5p (MIRT562940)
- hsa-mir-548c-5p (MIRT562941)
- hsa-mir-548bb-5p (MIRT562942)
- hsa-mir-548b-5p (MIRT562943)
- hsa-mir-548ay-5p (MIRT562944)
- hsa-mir-548au-5p (MIRT562945)
- hsa-mir-548as-5p (MIRT562946)
- hsa-mir-548ar-5p (MIRT562947)
- hsa-mir-548aq-5p (MIRT562948)
- hsa-mir-548ap-5p (MIRT562949)
- hsa-mir-548am-5p (MIRT562950)
- hsa-mir-548ak (MIRT562951)
- hsa-mir-548ae-5p (MIRT562952)
- hsa-mir-548ad-5p (MIRT562953)
- hsa-mir-548ab (MIRT562954)
- hsa-mir-548a-5p (MIRT562955)
- hsa-mir-548c-3p (MIRT562956)
- hsa-mir-1180-3p (MIRT732717)
miRNA Products
- Search ViGene Biosciences for TNIP2
Inhibitory RNA Products
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-
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Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNIP2 Gene
Localization for TNIP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TNIP2 Gene
- Cytoplasm. Nucleus.
- Cytosol (4)
- Nucleoplasm (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IBA | -- |
GO:0005829 | cytosol | TAS,IDA | -- |
Pathways & Interactions for TNIP2 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | Cytokine Signaling in Immune system | ||
3 | Innate Immune System |
.61
|
|
4 | IL-1 signaling pathway | ||
5 | Metabolism of proteins |
Pathways by source for TNIP2 Gene
1 BioSystems pathway for TNIP2 Gene
28 Reactome pathways for TNIP2 Gene
1 GeneGo (Thomson Reuters) pathway for TNIP2 Gene
Interacting Proteins for TNIP2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0006954 | inflammatory response | IEA | -- |
GO:0007249 | I-kappaB kinase/NF-kappaB signaling | IEA | -- |
Transcripts for TNIP2 Gene
mRNA/cDNA for TNIP2 Gene
- (3) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (178) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TNIP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TNIP2
- genomics-online: gRNA clones - Search results for available TNIP2 gene related products
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Vectors and viruses for KO, Activation, Repression, and more
-
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Clone Products
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- Applied Biological Materials Clones for TNIP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||
SP7: |
Expression for TNIP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNIP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of TNIP2 Gene:
TNIP2SOURCE GeneReport for Unigene cluster for TNIP2 Gene:
Hs.368551mRNA Expression by UniProt/SwissProt for TNIP2 Gene:
Q8NFZ5-TNIP2_HUMANEvidence on tissue expression from TISSUES for TNIP2 Gene
- Liver(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for TNIP2
-
OriGene qPCR primer pairs for TNIP2
- genomics-online: primer clones - Search results for available TNIP2 gene related products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNIP2 Gene
Orthologs for TNIP2 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TNIP2 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | TNIP2 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Tnip2 33 16 34 |
|
||
cow (Bos Taurus) |
Mammalia | TNIP2 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Tnip2 33 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
oppossum (Monodelphis domestica) |
Mammalia | TNIP2 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | TNIP2 33 34 |
|
||
tropical clawed frog (Silurana tropicalis) |
Amphibia | tnip2 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | LOC564279 33 |
|
||
TNIP2 34 |
|
OneToOne |
- Species where no ortholog for TNIP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TNIP2 Gene
Pseudogenes.org Pseudogenes for TNIP2 Gene
No data available for Paralogs for TNIP2 Gene
Variants for TNIP2 Gene
SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000097423 | -- | 2,758,349(-) | C/A | upstream_transcript_variant | |
rs1000189091 | -- | 2,746,858(-) | C/A | intron_variant | |
rs1000205122 | -- | 2,752,867(-) | G/A | intron_variant | |
rs1000257257 | -- | 2,752,531(-) | C/T | intron_variant | |
rs1000335260 | -- | 2,742,047(-) | C/T | 3_prime_UTR_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2189823 | CNV | deletion | 18987734 |
esv2664337 | CNV | deletion | 23128226 |
esv2726835 | CNV | deletion | 23290073 |
nsv1128023 | CNV | deletion | 24896259 |
nsv470002 | CNV | loss | 18288195 |
nsv516797 | CNV | loss | 19592680 |
Additional Variant Information for TNIP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TNIP2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNIP2 Gene
Disorders for TNIP2 Gene
Additional Disease Information for TNIP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TNIP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNIP2 Gene
Publications for TNIP2 Gene
- ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1. (PMID: 12933576) Tadros A … Brindle NP (Blood 2003) 2 3 4 22 58
- Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2. (PMID: 11390377) Van Huffel S … Beyaert R (The Journal of biological chemistry 2001) 2 3 4 22 58
- The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis. (PMID: 14653779) Liu WK … Chou CK (The Biochemical journal 2004) 3 4 22 58
- ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. (PMID: 15169888) Lang V … Ley SC (Molecular and cellular biology 2004) 3 4 22 58
- An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation. (PMID: 12595760) Liu WK … Su JY (Journal of biomedical science 2003) 3 4 22 58
Products for TNIP2 Gene
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Sources for TNIP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
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