TNIP2 Gene
protein-coding GIFtS: 55
GCID: GC04M002780
|
|
TNFAIP3 interacting protein 2
| |
Aliases
for TNIP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TNFAIP3 Interacting Protein 21 2 | | Fetal Liver LKB1-Interacting Protein2 3 | | FLIP11 2 3 5 | | A20-Binding Inhibitor Of NF-Kappa-B Activation 22 3 | | ABIN22 3 5 | | MGC42891 | | KLIP1 2 | | A20-Binding Inhibitor Of NF-KappaB Activation-22 | | ABIN-21 3 | | TNFAIP3-Interacting Protein 22 |
Export aliases for TNIP2 gene to outside databasesPrevious GC identifers: GC04M002726 GC04M002602 GC04P9I0140 GC04M002775 |
Summaries
for TNIP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TNIP2:
TNIP2 binds to the C-terminal zinc finger domain of A20 (TNFAIP3; MIM 191163) and is involved in activation of the ERK(see MAPK3; MIM 601795) MAP kinase pathway in various cell types (Van Huffel et al., 2001 (PubMed 11390377);Papoutsopoulou et al., 2006 (PubMed 16633345)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: TNIP2_HUMAN, Q8NFZ5Function: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG.Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathwaythat regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immuneresponse; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved inregulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act astranscriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involvingNF-kappa-B p50-p65 and p50-c-Rel complexes
Gene Wiki entry for TNIP2
|
Genomic Views
for TNIP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006051.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TNIP2 gene promoter:
RP58 Egr-1 AP-4 Max PPAR-alpha HEN1 FOXJ2 (long isoform) c-Myb FOXJ2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for TNIP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNIP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3TNIP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M002780: view genomic region
(about GC identifiers)
Start:
|
2,743,375 bp from pter |
End:
|
2,758,103 bp from pter |
Size:
|
14,729 bases |
Orientation:
|
minus strand |
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Proteins
for TNIP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TNIP2_HUMAN, Q8NFZ5 (See
protein sequence)Recommended Name: TNFAIP3-interacting protein 2 Size: 429 amino acids; 48700 Da
Subunit: Interacts with STK11/LKB1, TNFAIP3, IKBKG, NFKB1, MAP3K8, TEK, RIPK1, CHUK, IKBKB and SMARCD1. Interacts withpolyubiquitin
Subcellular location: Cytoplasm. Nucleus (Probable)
Secondary accessions: B1AKS4 B3KTY8 D3DVQ9 Q7L5L2 Q9BQR6 Q9H682Alternative splicing: 2 isoforms: Q8NFZ5-1 Q8NFZ5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TNIP2: NX_Q8NFZ5
Post-translational modifications:
In vitro phosphorylated by CHUK1
Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasomal degradationwhich can be impaired by IKK-A/CHUK or IKBKB probbaly involving deubiquitination1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NFZ5
TNIP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001154999.1 NP_077285.3
ENSEMBL proteins: ENSP00000427613 ENSP00000321203 ENSP00000426314 Reactome Protein details: Q8NFZ5
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TNIP2 for ontologies About GeneDecksing
TNIP2 Antibody Products:
Assay Products for TNIP2: |
Protein
Domains /
Families
for TNIP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TNIP2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NFZ5ProtoNet protein and cluster: Q8NFZ5 |
Function
for TNIP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TNIP2_HUMAN, Q8NFZ5Function: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG.Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathwaythat regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immuneresponse; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved inregulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act astranscriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involvingNF-kappa-B p50-p65 and p50-c-Rel complexes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TNIP2 (NM_024309) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNIP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNIP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNIP2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TNIP2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Tnip2tm1.1Sley for TNIP2
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Tnip2):
TNIP2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TNIP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_PDGF signaling via STATs and NF-kB | | | 2 | Cytokine Signaling in Immune system | | | 3 | Immune System | | | 4 | TNF-alpha/NF-kB Signaling Pathway | | | 5 | Interleukin-1 signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TNIP2
1  GeneGo (Thomson Reuters) Pathway for TNIP2
1  BioSystems Pathway for TNIP2
4 
Reactome Pathways for TNIP2
TNIP2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNIP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/25 Interacting proteins for TNIP2 (Q8NFZ51, 2, 3 ENSP000003212034) via UniProtKB, MINT, STRING, and/or I2D (see all 25)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| NFKB1 | P198382, 3, ENSP000002265744 | MINT-47901 MINT-48676 MINT-48554 MINT-47882 I2D:
score=5 STRING: ENSP00000226574 | | NFKB2 | Q006532, 3, ENSP000001894444 | MINT-47913 MINT-48746 I2D:
score=4 STRING: ENSP00000189444 | | STK11 | Q158311, 3, ENSP000003248564 | EBI-359372,EBI-306838 I2D:
score=2 STRING: ENSP00000324856 | | MAP3K8 | P412791, 2, 3, ENSP000002630564 | EBI-359372,EBI-354900 MINT-47826 I2D:
score=7 STRING: ENSP00000263056 | | TNFAIP3 | P215802, 3, ENSP000002372894 | MINT-17246 I2D:
score=5 STRING: ENSP00000237289 |
About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table
TNIP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TNIP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TNIP2 for compounds About GeneDecksing
 Browse Tocris compounds for TNIP2
1 Novoseek chemical compound relationship for TNIP2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| zinc |
33.5 |
2 |
12933576 (1), 11390377 (1) |
Search CenterWatch for drugs/clinical trials and news about TNIP2
|
Transcripts
for TNIP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TNIP2 gene (2 alternative transcripts): NM_001161527.1 NM_024309.3 Unigene Cluster for TNIP2: TNFAIP3 interacting protein 2 Hs.744037 [show with all ESTs]Unigene Representative Sequence: NM_0243097 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000510267(uc003gff.2) ENST00000315423(uc003gfg.2) ENST00000503235
ENST00000502256 ENST00000505186 ENST00000507686 ENST00000511352
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TNIP2 (NM_024309) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNIP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNIP2 |
Additional cDNA sequence: AF372839.1 AJ304866.1 AK026176.1 AK096296.1 BC002740.2 10 DOTS entries: DT.415196 DT.100820074 DT.121251338 DT.121251340 DT.100820077 DT.92429628 DT.40132230 DT.95069099 DT.95143857 DT.40206146 24/178 AceView cDNA sequences (see all 178): BM763430 AI820016 CD366862 AI223866 CF529747 AI668765 CF529892 BM790503 BF338059 BG059982 CR602013 CB113232 BQ889849 AI873451 CB157550 BM762891 BM916340 CA430186 CF529108 CR591629 BQ772422 W61318 AI056573 AI553708
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TNIP2 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|
|
| SP1: | | | | | - | | - | | | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | - | | - | | | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TNIP2
|
Expression
for TNIP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TNIP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGCACTGA
About this image
See TNIP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNIP2
SOURCE GeneReport for Unigene cluster: Hs.744037
UniProtKB/Swiss-Prot: TNIP2_HUMAN, Q8NFZ5Tissue specificity: Ubiquitously expressed in all tissues examined
SABiosciences Custom PCR Arrays for TNIP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNIP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNIP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNIP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNIP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNIP2 |
Orthologs
for TNIP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TNIP2 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for TNIP2 (if available)
TreeFam Gene Tree for TNIP2 (if available) |
Paralogs
for TNIP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TNIP2 gene
TNIP2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TNIP2
PGOHUM00000241244
|
Genomic Variants
for TNIP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TNIP2
3 CNVs: 51374 30193 30194
1 Indel: 46625 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TNIP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TNIP2 for disorders About GeneDecksing
OMIM gene information: 610669
OMIM disorders: --
8  diseases for TNIP2: About MalaCardswolf-hirschhorn syndrome diffuse large b-cell lymphoma b-cell lymphomas rheumatoid arthritis
endometrial cancer arthritis hypoxia leukemia
1 disease from the University of Copenhagen DISEASES database for TNIP2:Wolf-Hirschhorn syndrome 1 Novoseek disease relationship for TNIP2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
1 |
12595760 (1) |
Human Genome Epidemiology (HuGE) Navigator: TNIP2 (1 document)
Export disorders for TNIP2 gene to outside databases
|
Publications
for TNIP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TNIP2 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with TNIP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1. (PubMed id 12933576)1, 2, 3, 9 Tadros A....Brindle N.P. (2003)
- Identification of a novel A20-binding inhibitor of nuclear factor- kappaB activation termed ABIN-2. (PubMed id 11390377)1, 2, 3, 9 Van Huffel S.C.... Beyaert R. (2001)
- ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. (PubMed id 15169888)1, 2, 9 Lang V....Ley S.C. (2004)
- The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis. (PubMed id 14653779)1, 2, 9 Liu W.-K.... Chou C.-K. (2004)
- The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2. (PubMed id 12609966)1, 2, 9 Hughes D.P....Brindle N.P. (2003)
- An LKB1-interacting protein negatively regulates TNFalpha-induced NF- kappaB activation. (PubMed id 12595760)1, 2, 9 Liu W.K.... Su J.Y. (2003)
- The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation. (PubMed id 12753905)1, 2, 9 Chien C.Y....Su J.Y. (2003)
- Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions. (PubMed id 11389905)1, 2, 9 Klinkenberg M....Beyaert R. (2001)
- A20-binding inhibitor of nuclear factor-kappaB (NF-ka ppaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alp ha (IKKalpha)-mediated NF-kappaB transcriptional activity. (PubMed id 21784860)1, 2 Leotoing L....Baud V. (2011)
- A20, ABIN-1/2, and CARD11 mutations and their prognos tic value in gastrointestinal diffuse large B-cell lymphoma. (PubMed id 21266526)1, 2 Dong G....Du M.Q. (2011)
|
External Searches for TNIP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TNIP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TNIP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TNIP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TNIP2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TNIP2 gene:
Search GeneIP for patents involving TNIP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TNIP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TNIP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNIP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNIP2 | | | OriGene Protein Over-expression Lysate for TNIP2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TNIP2 | | OriGene 3'-UTR Clone for TNIP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TNIP2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TNIP2 | | OriGene Custom Protein Services for TNIP2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TNIP2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNIP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNIP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNIP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNIP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNIP2 |
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| | | | Search Tocris compounds for TNIP2 |
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 | | | TNIP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNIP2 |
|  |  |  | | | | Search ThermoFisher Antibodies for TNIP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNIP2 |
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