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TNIP2 Gene

protein-coding   GIFtS: 59
GCID: GC04M002780

TNFAIP3 Interacting Protein 2

  Search for TNIP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TNFAIP3 Interacting Protein 21 2     KLIP2
ABIN22 3 5     A20-Binding Inhibitor Of NF-KappaB Activation-22
FLIP12 3 5     TNFAIP3-Interacting Protein 22
Fetal Liver LKB1-Interacting Protein2 3     ABIN-23
A20-Binding Inhibitor Of NF-Kappa-B Activation 22 3     

External Ids:    HGNC: 191181   Entrez Gene: 791552   Ensembl: ENSG000001688847   OMIM: 6106695   UniProtKB: Q8NFZ53   

Export aliases for TNIP2 gene to outside databases

Previous GC identifers: GC04M002726 GC04M002602 GC04P9I0140 GC04M002775


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNIP2 Gene:
TNIP2 binds to the C-terminal zinc finger domain of A20 (TNFAIP3; MIM 191163) and is involved in activation of the
ERK (see MAPK3; MIM 601795) MAP kinase pathway in various cell types (Van Huffel et al., 2001 (PubMed 11390377);
Papoutsopoulou et al., 2006 (PubMed 16633345)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TNIP2 Gene:
TNIP2 (TNFAIP3 interacting protein 2) is a protein-coding gene. GO annotations related to this gene include protein kinase binding and polyubiquitin binding.

UniProtKB/Swiss-Prot: TNIP2_HUMAN, Q8NFZ5
Function: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector
NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4
signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway
during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability
of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial
survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated
NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes

Gene Wiki entry for TNIP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNIP2 gene promoter:
         RP58   Egr-1   AP-4   Max   PPAR-alpha   HEN1   FOXJ2 (long isoform)   c-Myb   FOXJ2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNIP2 promoter sequence
   Search Chromatin IP Primers for TNIP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

TNIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNIP2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M002780:  view genomic region     (about GC identifiers)

Start:
2,743,375 bp from pter      End:
2,758,103 bp from pter
Size:
14,729 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TNIP2_HUMAN, Q8NFZ5 (See protein sequence)
Recommended Name: TNFAIP3-interacting protein 2  
Size: 429 amino acids; 48700 Da
Subunit: Interacts with STK11/LKB1, TNFAIP3, IKBKG, NFKB1, MAP3K8, TEK, RIPK1, CHUK, IKBKB and SMARCD1. Interacts
with polyubiquitin
Secondary accessions: B1AKS4 B3KTY8 D3DVQ9 Q7L5L2 Q9BQR6 Q9H682
Alternative splicing: 2 isoforms:  Q8NFZ5-1   Q8NFZ5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNIP2: NX_Q8NFZ5

Explore proteomics data for TNIP2 at MOPED

Post-translational modifications: 

  • In vitro phosphorylated by CHUK1
  • Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasomal
    degradation which can be impaired by IKK-A/CHUK or IKBKB probbaly involving deubiquitination1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TNIP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001154999.1  NP_077285.3  

    ENSEMBL proteins: 
     ENSP00000427613   ENSP00000321203   ENSP00000426314  
    Reactome Protein details: Q8NFZ5

    TNIP2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR022008 EABR

    Graphical View of Domain Structure for InterPro Entry Q8NFZ5

    ProtoNet protein and cluster: Q8NFZ5


    Find genes that share domains with TNIP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNIP2_HUMAN, Q8NFZ5
    Function: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector
    NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4
    signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway
    during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability
    of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial
    survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated
    NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12595760
    GO:0019901protein kinase binding IDA--
    GO:0031593polyubiquitin binding IDA18212736
         
    Find genes that share ontologies with TNIP2           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tnip2):
     hematopoietic system  immune system 

    Find genes that share phenotypes with TNIP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tnip2tm1.1Sley for TNIP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNIP2
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    miRNA
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    miRTarBase miRNAs that target TNIP2:
    hsa-mir-218-5p (MIRT024247), hsa-mir-24-3p (MIRT030507)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNIP2_HUMAN, Q8NFZ5: Cytoplasm. Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with TNIP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNIP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Cytokine Signaling in Immune system0.59
    2Interleukin-1 signaling
    Interleukin-1 signaling0.45
    3Signaling by Interleukins
    Signaling by Interleukins0.42
    4Immune response IL 23 signaling pathway
    Development Angiopoietin Tie2 signaling0.38
    5TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    Find genes that share SuperPaths with TNIP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for TNIP2
        Development Angiopoietin - Tie2 signaling

    1 BioSystems Pathway for TNIP2
        TNF-alpha/NF-kB Signaling Pathway

    1 Reactome Pathway for TNIP2
        Interleukin-1 signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TNIP2
    Interactions:

        GeneGlobe Interaction Network for TNIP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for TNIP2 (Q8NFZ51, 2, 3 ENSP000003212034) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB1P198382, 3, ENSP000002265744MINT-47901 MINT-48676 MINT-48554 MINT-47882 I2D: score=5 STRING: ENSP00000226574
    NFKB2Q006532, 3, ENSP000001894444MINT-47913 MINT-48746 I2D: score=4 STRING: ENSP00000189444
    STK11Q158311, 3, ENSP000003248564EBI-359372,EBI-306838 I2D: score=2 STRING: ENSP00000324856
    MAP3K8P412791, 2, 3, ENSP000002630564EBI-359372,EBI-354900 MINT-47826 I2D: score=7 STRING: ENSP00000263056
    TNFAIP3P215802, 3, ENSP000002372894MINT-17246 I2D: score=5 STRING: ENSP00000237289
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006915apoptotic process IEA--
    GO:0006954inflammatory response IEA--
    GO:0007249I-kappaB kinase/NF-kappaB signaling IEA--
    GO:0023035CD40 signaling pathway ISS--

    Find genes that share ontologies with TNIP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNIP2

    1 Novoseek inferred chemical compound relationship for TNIP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 33.5 2 12933576 (1), 11390377 (1)



    Find genes that share compounds with TNIP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNIP2 gene (2 alternative transcripts): 
    NM_001161527.1  NM_024309.3  

    Unigene Cluster for TNIP2:

    TNFAIP3 interacting protein 2
    Hs.368551  [show with all ESTs]
    Unigene Representative Sequence: NM_024309
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510267(uc003gff.2) ENST00000315423(uc003gfg.2) ENST00000503235
    ENST00000502256 ENST00000505186 ENST00000507686 ENST00000511352
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TNIP2
      QuantiFast Probe-based Assays in human, mouse, rat TNIP2

    Additional mRNA sequence: 

    AF372839.1 AJ304866.1 AK026176.1 AK096296.1 BC002740.2 

    10 DOTS entries:

    DT.415196  DT.100820074  DT.121251338  DT.121251340  DT.100820077  DT.92429628  DT.40132230  DT.95069099 
    DT.95143857  DT.40206146 

    Selected AceView cDNA sequences (see all 178):

    BU845032 CR602013 CA430186 AA804573 BM916340 BX279533 CR592080 CF529892 
    AI668765 W61318 BQ772422 CF529747 BM764153 AI820016 AI873451 CR617764 
    AF372839 BM476727 AL137262 AI223866 CF529108 BU625448 CD366862 CR624012 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TNIP2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:              -     -           -     -           -                                             
    SP2:                                -     -           -                                             
    SP3:                                                  -                                             
    SP4:              -     -           -     -           -     -     -                                 
    SP5:                                -     -           -                                             


    ECgene alternative splicing isoforms for TNIP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNIP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGCACTGA
    TNIP2 Expression
    About this image


    TNIP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    TNIP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNIP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368551

    UniProtKB/Swiss-Prot: TNIP2_HUMAN, Q8NFZ5
    Tissue specificity: Ubiquitously expressed in all tissues examined

        Custom PCR Arrays for TNIP2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNIP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNIP2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnip21 , 5 TNFAIP3 interacting protein 21, 5 80.14(n)1
    79.21(a)1
      5 (17.89 cM)5
    2311301  NM_139064.21  NP_620703.11 
     344960875 
    chicken
    (Gallus gallus)
    Aves TNIP21 TNFAIP3 interacting protein 2 61.55(n)
    54.28(a)
      422884  NM_001031166.1  NP_001026337.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tnip21 TNFAIP3 interacting protein 2 59.16(n)
    48.02(a)
      100379985  XM_002940954.2  XP_002941000.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5642791 TNFAIP3-interacting protein 2-like 48.08(n)
    38(a)
      564279  XM_687625.5  XP_692717.4 


    ENSEMBL Gene Tree for TNIP2 (if available)
    TreeFam Gene Tree for TNIP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNIP2 gene

    Find genes that share paralogs with TNIP2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TNIP2
    PGOHUM00000241244


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNIP2 (see all 434)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1164127811,2,,4
    C,FPatients with gastrointestinal diffuse large cell lymphoma4 --2746567(+) CAGCTC/TGGGCT 4 K E mis13Minor allele frequency- T:0.02NA EU 5989
    rs1161298951,2,,4
    C,FPatients with gastrointestinal diffuse large cell lymphoma4 --2746583(+) GGGATC/ATGCAG 4 /Q /H mis13Minor allele frequency- A:0.02WA NA EU 5991
    rs1421053311,2
    --2740640(+) CTGTCA/GCCCAG 1 -- us2k10--------
    rs92911581,2
    C,F,H--2743015(+) AAAAAT/CGTGAA 2 -- int16Minor allele frequency- C:0.45NA WA EA 130
    rs1882656881,2
    --2743053(+) TACATC/GTTGCT 2 -- int10--------
    rs131463131,2
    C,F--2743060(+) tgctcC/Tgtgct 2 -- int14Minor allele frequency- T:0.05NA EA 244
    rs1163682261,2
    C,F--2743177(+) GTGATC/TGTGTG 2 -- int11Minor allele frequency- T:0.09WA 118
    rs1156864011,2
    C,F--2743191(+) TAATAC/TTTGAC 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1930672401,2
    --2743197(+) TTGACA/GCACTC 2 -- int10--------
    rs1126599791,2
    F--2743226(+) GTTCCG/ATTAGT 2 -- int12Minor allele frequency- A:0.50CSA 4

    HapMap Linkage Disequilibrium report for TNIP2 (2743375 - 2758103 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TNIP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726835CNV Deletion23290073
    esv2189823CNV Deletion18987734
    esv2664337CNV Deletion23128226
    dgv5427n71CNV Loss21882294
    nsv878444CNV Loss21882294
    nsv470002CNV Loss18288195
    nsv516797CNV Loss19592680
    dgv5426n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TNIP2
    DNA2.0 Custom Variant and Variant Library Synthesis for TNIP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610669    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TNIP2:
    Wolf-Hirschhorn syndrome

    Find genes that share disorders with TNIP2           About GenesLikeMe

    1 Novoseek inferred disease relationship for TNIP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 12595760 (1)

    Genetic Association Database (GAD): TNIP2
    Human Genome Epidemiology (HuGE) Navigator: TNIP2 (1 document)

    Export disorders for TNIP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TNIP2 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with TNIP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1. (PubMed id 12933576)1, 2, 3, 9 Tadros A.... Brindle N.P. (Blood 2003)
    2. Identification of a novel A20-binding inhibitor of nuclear factor- kappaB activation termed ABIN-2. (PubMed id 11390377)1, 2, 3, 9 Van Huffel S.C.... Beyaert R. (J. Biol. Chem. 2001)
    3. ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. (PubMed id 15169888)1, 2, 9 Lang V.... Ley S.C. (Mol. Cell. Biol. 2004)
    4. The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis. (PubMed id 14653779)1, 2, 9 Liu W.-K.... Chou C.-K. (Biochem. J. 2004)
    5. The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2. (PubMed id 12609966)1, 2, 9 Hughes D.P.... Brindle N.P. (Circ. Res. 2003)
    6. An LKB1-interacting protein negatively regulates TNFalpha-induced NF- kappaB activation. (PubMed id 12595760)1, 2, 9 Liu W.-K.... Su J.-Y. (J. Biomed. Sci. 2003)
    7. The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation. (PubMed id 12753905)1, 2, 9 Chien C.Y.... Su J.Y. (FEBS Lett. 2003)
    8. Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions. (PubMed id 11389905)1, 2, 9 Klinkenberg M.... Beyaert R. (FEBS Lett. 2001)
    9. A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity. (PubMed id 21784860)1, 2 Leotoing L.... Baud V. (J. Biol. Chem. 2011)
    10. A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma. (PubMed id 21266526)1, 2 Dong G.... Du M.Q. (Clin. Cancer Res. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 79155 HGNC: 19118 AceView: TNIP2 Ensembl:ENSG00000168884 euGenes: HUgn79155
    ECgene: TNIP2 H-InvDB: TNIP2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TNIP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TNIP2 gene:
    Search GeneIP for patents involving TNIP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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