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Aliases for TNIP2 Gene

Aliases for TNIP2 Gene

  • TNFAIP3 Interacting Protein 2 2 3 5
  • Fetal Liver LKB1-Interacting Protein 3 4
  • ABIN2 3 4
  • FLIP1 3 4
  • A20-Binding Inhibitor Of NF-Kappa-B Activation 2 4
  • A20-Binding Inhibitor Of NF-KappaB Activation-2 3
  • TNFAIP3-Interacting Protein 2 3
  • ABIN-2 4
  • KLIP 3

External Ids for TNIP2 Gene

Previous GeneCards Identifiers for TNIP2 Gene

  • GC04M002726
  • GC04M002602
  • GC04P9I0140
  • GC04M002775
  • GC04M002780

Summaries for TNIP2 Gene

Entrez Gene Summary for TNIP2 Gene

  • This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]

GeneCards Summary for TNIP2 Gene

TNIP2 (TNFAIP3 Interacting Protein 2) is a Protein Coding gene. Among its related pathways are IL-1 signaling pathway and Activated TLR4 signalling. GO annotations related to this gene include protein kinase binding and polyubiquitin binding.

UniProtKB/Swiss-Prot for TNIP2 Gene

  • Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.

Gene Wiki entry for TNIP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNIP2 Gene

Genomics for TNIP2 Gene

Regulatory Elements for TNIP2 Gene

Enhancers for TNIP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G002792 1.8 FANTOM5 ENCODE dbSUPER 15.1 -43.9 -43942 15.2 HDGF PKNOX1 MLX AGO1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SH3BP2 NOP14-AS1 TNIP2 NELFA ADD1 GRK4 CFAP99 ZFYVE28 HTT
GH04G002481 1.3 Ensembl ENCODE dbSUPER 15 +272.0 271954 5.6 HDGF PKNOX1 EGR1 ZNF143 RELB ETV6 IKZF2 CREM EGR2 ZNF263 RNF4 ZFYVE28 TNIP2 LOC105374353 MXD4 HAUS3 POLN ENSG00000251148 SH3BP2 GC04P002484
GH04G002857 1.5 Ensembl ENCODE dbSUPER 11.9 -104.1 -104103 5.7 PKNOX1 ATF1 ARID4B FEZF1 YY1 TCF12 ZNF121 CBX5 KLF7 FOS GRK4 NOP14-AS1 NOP14 TNIP2 HTT GC04P002844 GC04P002845 GC04P002843 GC04P002904 PIR46708
GH04G002866 1.5 Ensembl ENCODE dbSUPER 11.9 -111.3 -111329 3.4 ATF1 FOXA2 ARNT ARID4B YY1 TCF12 ZNF766 ELK1 GATA2 ZNF263 GRK4 ADD1 TNIP2 NOP14-AS1 MFSD10 NOP14 GC04P002843 GC04P002844 GC04P002845 GC04P002904
GH04G002848 1.3 Ensembl ENCODE dbSUPER 11.9 -92.5 -92452 2.9 CTCF KLF1 PKNOX1 RAD21 TEAD3 ZNF121 ZFHX2 HNF4G ZNF600 KLF8 GRK4 TNIP2 NOP14 NOP14-AS1 GC04P002843 GC04P002844 GC04P002845 PIR46708 GC04P002904
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNIP2 on UCSC Golden Path with GeneCards custom track

Promoters for TNIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000164991 376 1201 HDGF ATF1 FOXA2 CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF48

Genomic Location for TNIP2 Gene

Chromosome:
4
Start:
2,741,648 bp from pter
End:
2,756,376 bp from pter
Size:
14,729 bases
Orientation:
Minus strand

Genomic View for TNIP2 Gene

Genes around TNIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNIP2 Gene

Proteins for TNIP2 Gene

  • Protein details for TNIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFZ5-TNIP2_HUMAN
    Recommended name:
    TNFAIP3-interacting protein 2
    Protein Accession:
    Q8NFZ5
    Secondary Accessions:
    • B1AKS4
    • B3KTY8
    • D3DVQ9
    • Q7L5L2
    • Q9BQR6
    • Q9H682

    Protein attributes for TNIP2 Gene

    Size:
    429 amino acids
    Molecular mass:
    48700 Da
    Quaternary structure:
    • Interacts with STK11/LKB1, TNFAIP3, IKBKG, NFKB1, MAP3K8, TEK, RIPK1, CHUK, IKBKB and SMARCD1. Interacts with polyubiquitin.

    Alternative splice isoforms for TNIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNIP2 Gene

Post-translational modifications for TNIP2 Gene

  • In vitro phosphorylated by CHUK.
  • Ubiquitinated; undergoes Lys-48-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probably involving deubiquitination.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNIP2 Gene

No data available for DME Specific Peptides for TNIP2 Gene

Domains & Families for TNIP2 Gene

Protein Domains for TNIP2 Gene

Suggested Antigen Peptide Sequences for TNIP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNIP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TNIP2 Gene

Function for TNIP2 Gene

Molecular function for TNIP2 Gene

UniProtKB/Swiss-Prot Function:
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.

Gene Ontology (GO) - Molecular Function for TNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12595760
GO:0019901 protein kinase binding IDA 21784860
GO:0031593 polyubiquitin binding IDA 18212736
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TNIP2: view
genes like me logo Genes that share phenotypes with TNIP2: view

Animal Models for TNIP2 Gene

MGI Knock Outs for TNIP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNIP2 Gene

Localization for TNIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNIP2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNIP2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Gene Ontology (GO) - Cellular Components for TNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with TNIP2: view

Pathways & Interactions for TNIP2 Gene

genes like me logo Genes that share pathways with TNIP2: view

Pathways by source for TNIP2 Gene

1 GeneGo (Thomson Reuters) pathway for TNIP2 Gene

SIGNOR curated interactions for TNIP2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling IEA --
genes like me logo Genes that share ontologies with TNIP2: view

Drugs & Compounds for TNIP2 Gene

(1) Drugs for TNIP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TNIP2: view

Transcripts for TNIP2 Gene

Unigene Clusters for TNIP2 Gene

TNFAIP3 interacting protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNIP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - - - - - - -
SP5: - - -
SP6: - - -
SP7:

Relevant External Links for TNIP2 Gene

GeneLoc Exon Structure for
TNIP2
ECgene alternative splicing isoforms for
TNIP2

Expression for TNIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNIP2 Gene

This gene is overexpressed in Placenta (15.8), Liver (13.6), Monocytes (9.0), Blymphocyte (8.6), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNIP2 Gene



Protein tissue co-expression partners for TNIP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNIP2 Gene:

TNIP2

SOURCE GeneReport for Unigene cluster for TNIP2 Gene:

Hs.368551

mRNA Expression by UniProt/SwissProt for TNIP2 Gene:

Q8NFZ5-TNIP2_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues examined.

Evidence on tissue expression from TISSUES for TNIP2 Gene

  • Liver(4.3)
genes like me logo Genes that share expression patterns with TNIP2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNIP2 Gene

Orthologs for TNIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNIP2 34 35
  • 86.26 (n)
dog
(Canis familiaris)
Mammalia TNIP2 34 35
  • 80.61 (n)
mouse
(Mus musculus)
Mammalia Tnip2 34 16 35
  • 80.14 (n)
cow
(Bos Taurus)
Mammalia TNIP2 34 35
  • 79.57 (n)
rat
(Rattus norvegicus)
Mammalia Tnip2 34
  • 79.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 53 (a)
OneToMany
-- 35
  • 48 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TNIP2 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNIP2 34 35
  • 61.55 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tnip2 34
  • 59.16 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC564279 34
  • 48.08 (n)
TNIP2 35
  • 32 (a)
OneToOne
Species where no ortholog for TNIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNIP2 Gene

ENSEMBL:
Gene Tree for TNIP2 (if available)
TreeFam:
Gene Tree for TNIP2 (if available)

Paralogs for TNIP2 Gene

Pseudogenes.org Pseudogenes for TNIP2 Gene

genes like me logo Genes that share paralogs with TNIP2: view

No data available for Paralogs for TNIP2 Gene

Variants for TNIP2 Gene

Sequence variations from dbSNP and Humsavar for TNIP2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000097423 -- 2,758,349(+) AGCCA(A/C)CACGC upstream-variant-2KB
rs1000189091 -- 2,746,858(+) TGGCA(A/C)ACAGA intron-variant
rs1000205122 -- 2,752,867(+) CATGC(A/G)ACCCC intron-variant
rs1000257257 -- 2,752,531(+) GGGAG(C/T)CCTCA intron-variant
rs1000335260 -- 2,742,047(+) CTCCA(C/T)CTCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TNIP2 Gene

Variant ID Type Subtype PubMed ID
esv2189823 CNV deletion 18987734
esv2664337 CNV deletion 23128226
esv2726835 CNV deletion 23290073
nsv1128023 CNV deletion 24896259
nsv470002 CNV loss 18288195
nsv516797 CNV loss 19592680

Variation tolerance for TNIP2 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.53; 85.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNIP2 Gene

Disorders for TNIP2 Gene

Relevant External Links for TNIP2

Genetic Association Database (GAD)
TNIP2
Human Genome Epidemiology (HuGE) Navigator
TNIP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNIP2

No disorders were found for TNIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNIP2 Gene

Publications for TNIP2 Gene

  1. ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1. (PMID: 12933576) Tadros A. … Brindle N.P. (Blood 2003) 2 3 4 22 64
  2. Identification of a novel A20-binding inhibitor of nuclear factor- kappaB activation termed ABIN-2. (PMID: 11390377) Van Huffel S.C. … Beyaert R. (J. Biol. Chem. 2001) 2 3 4 22 64
  3. The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis. (PMID: 14653779) Liu W.-K. … Chou C.-K. (Biochem. J. 2004) 3 4 22 64
  4. ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. (PMID: 15169888) Lang V. … Ley S.C. (Mol. Cell. Biol. 2004) 3 4 22 64
  5. An LKB1-interacting protein negatively regulates TNFalpha-induced NF- kappaB activation. (PMID: 12595760) Liu W.-K. … Su J.-Y. (J. Biomed. Sci. 2003) 3 4 22 64

Products for TNIP2 Gene

Sources for TNIP2 Gene

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