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Aliases for TNIP1 Gene

Aliases for TNIP1 Gene

  • TNFAIP3 Interacting Protein 1 2 3 5
  • A20-Binding Inhibitor Of NF-Kappa-B Activation 1 3 4
  • Virion-Associated Nuclear Shuttling Protein 3 4
  • HIV-1 Nef-Interacting Protein 3 4
  • Nef-Associated Factor 1 SNP 2 3
  • Nip40-1 3 4
  • ABIN-1 3 4
  • NAF1 3 4
  • VAN 3 4
  • Virion-Associated Nuclear-Shuttling Protein 2
  • TNFAIP3-Interacting Protein 1 3
  • Nef-Associated Factor 1 4
  • KIAA0113 4
  • HVAN 4

External Ids for TNIP1 Gene

Previous GeneCards Identifiers for TNIP1 Gene

  • GC05M150478
  • GC05M151006
  • GC05M150392
  • GC05M150438
  • GC05M150389
  • GC05M145555
  • GC05M150409

Summaries for TNIP1 Gene

Entrez Gene Summary for TNIP1 Gene

  • This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for TNIP1 Gene

TNIP1 (TNFAIP3 Interacting Protein 1) is a Protein Coding gene. Diseases associated with TNIP1 include Psoriatic Arthritis and Chronic Intestinal Vascular Insufficiency. Among its related pathways are Deubiquitination and Immune response IL-23 signaling pathway. GO annotations related to this gene include binding and mitogen-activated protein kinase binding. An important paralog of this gene is TNIP3.

UniProtKB/Swiss-Prot for TNIP1 Gene

  • Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.

Gene Wiki entry for TNIP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNIP1 Gene

Genomics for TNIP1 Gene

Regulatory Elements for TNIP1 Gene

Enhancers for TNIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G151074 2.1 FANTOM5 Ensembl ENCODE dbSUPER 24.2 +12.3 12306 13.6 CREB3L1 AGO1 DMAP1 YY1 ZNF263 SP3 MCM3 NFYC TBX21 MEF2D TNIP1 ZNF300P1 ANXA6 RBM22 CCDC69 IRGM CD74 DCTN4 SLC36A1 SMIM3
GH05G151058 1.7 FANTOM5 Ensembl ENCODE dbSUPER 25.3 +33.7 33680 3.0 HDGF WRNIP1 RAD21 YY1 ZNF121 ZNF366 FOS RELB ETV6 IKZF2 TNIP1 CCDC69 RBM22 DCTN4 SLC36A1 GC05P151028
GH05G151091 2 FANTOM5 Ensembl ENCODE dbSUPER 19.6 -3.5 -3541 10.6 HDGF PKNOX1 FOXA2 ARNT WRNIP1 SIN3A YY1 ZNF766 ZNF143 ZNF207 TNIP1 ANXA6 GPX3 RBM22 CCDC69 DCTN4 SLC36A1 SMIM3
GH05G151208 2 FANTOM5 Ensembl ENCODE dbSUPER 17.4 -122.9 -122884 16.9 HDGF FOXA2 PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 SIN3A YY1 ZNF766 GM2A TNIP1 ANXA6 CCDC69 SLC36A1 LINC01933 DCTN4
GH05G151067 2 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +24.6 24645 3.9 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MEF2D ZNF610 TNIP1 ZNF300P1 RBM22 CCDC69 DCTN4 SMIM3 SLC36A1 GC05P151028
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNIP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNIP1 Gene

Chromosome:
5
Start:
151,029,943 bp from pter
End:
151,093,577 bp from pter
Size:
63,635 bases
Orientation:
Minus strand

Genomic View for TNIP1 Gene

Genes around TNIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNIP1 Gene

Proteins for TNIP1 Gene

  • Protein details for TNIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15025-TNIP1_HUMAN
    Recommended name:
    TNFAIP3-interacting protein 1
    Protein Accession:
    Q15025
    Secondary Accessions:
    • A4F1W8
    • A4F1W9
    • A4F1X2
    • A4F1X4
    • A4F1X5
    • A4F1X6
    • A4F1X7
    • A4F1X9
    • B7Z699
    • E7EPY1
    • E7ET96
    • O76008
    • Q05KP3
    • Q05KP4
    • Q6N077
    • Q96EL9
    • Q99833
    • Q9H1J3

    Protein attributes for TNIP1 Gene

    Size:
    636 amino acids
    Molecular mass:
    71864 Da
    Quaternary structure:
    • Interacts with TNFAIP3 and IKBKG (polyubiquitinated); facilitates TNFAIP3-mediated de-ubiquitination of NEMO/IKBKG. Interacts with polyubiquitin. Interacts with MAPK1, SELPLG and PIK3CD. Interacts with IRAK1 (polyubiquitinated). Interacts with MYD88; the interaction is indicative for participation in an activated TLR-signaling complex. Interacts with HIV-1 matrix protein. Interacts with Shigella flexneri ipah9.8; the interaction promotes polyubiquitination of IKBKG.
    SequenceCaution:
    • Sequence=AAB41438.1; Type=Frameshift; Positions=152, 154; Evidence={ECO:0000305};

    Alternative splice isoforms for TNIP1 Gene

neXtProt entry for TNIP1 Gene

Post-translational modifications for TNIP1 Gene

  • Phosphorylation at Tyr-552 by SRC-family kinases recruits phosphoinositide-3-kinase (PI3K) PIK3CD:p85 heterodimer which results in integrin activation and leukocyte adhesion to activated endothelium during inflammation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TNIP1 Gene

Domains & Families for TNIP1 Gene

Protein Domains for TNIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNIP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNIP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TNIP1 Gene

Function for TNIP1 Gene

Molecular function for TNIP1 Gene

UniProtKB/Swiss-Prot Function:
Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.

Gene Ontology (GO) - Molecular Function for TNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 contributes_to thiol-dependent ubiquitin-specific protease activity IDA 16684768
GO:0005515 protein binding IPI 15474016
GO:0042802 identical protein binding IPI 21988832
GO:0051019 mitogen-activated protein kinase binding IDA 12220502
genes like me logo Genes that share ontologies with TNIP1: view
genes like me logo Genes that share phenotypes with TNIP1: view

Animal Models for TNIP1 Gene

MGI Knock Outs for TNIP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNIP1 Gene

Localization for TNIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNIP1 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNIP1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for TNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 9923610
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TNIP1: view

Pathways & Interactions for TNIP1 Gene

genes like me logo Genes that share pathways with TNIP1: view

Pathways by source for TNIP1 Gene

1 Cell Signaling Technology pathway for TNIP1 Gene
1 BioSystems pathway for TNIP1 Gene

Gene Ontology (GO) - Biological Process for TNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002755 MyD88-dependent toll-like receptor signaling pathway ISS --
GO:0006412 translation TAS 9923610
GO:0006952 defense response TAS 9923610
GO:0006954 inflammatory response IEA --
GO:0007159 leukocyte cell-cell adhesion IMP 17632516
genes like me logo Genes that share ontologies with TNIP1: view

No data available for SIGNOR curated interactions for TNIP1 Gene

Drugs & Compounds for TNIP1 Gene

No Compound Related Data Available

Transcripts for TNIP1 Gene

Unigene Clusters for TNIP1 Gene

TNFAIP3 interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNIP1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1: -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c · 23d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10: -
SP11: - -
SP12:
SP13:
SP14:

Relevant External Links for TNIP1 Gene

GeneLoc Exon Structure for
TNIP1
ECgene alternative splicing isoforms for
TNIP1

Expression for TNIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNIP1 Gene

This gene is overexpressed in Whole Blood (x6.5).

Protein differential expression in normal tissues from HIPED for TNIP1 Gene

This gene is overexpressed in Amniocyte (55.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNIP1 Gene



Protein tissue co-expression partners for TNIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNIP1 Gene:

TNIP1

SOURCE GeneReport for Unigene cluster for TNIP1 Gene:

Hs.355141

mRNA Expression by UniProt/SwissProt for TNIP1 Gene:

Q15025-TNIP1_HUMAN
Tissue specificity: Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed. Expression of isoform 1 and isoform 7 increases in leukemic cells.

Evidence on tissue expression from TISSUES for TNIP1 Gene

  • Lung(4.7)
  • Blood(4.6)
  • Intestine(4.5)
  • Liver(4.4)
  • Bone marrow(4.3)
  • Nervous system(3.6)
  • Muscle(2.8)
  • Pancreas(2.8)
  • Skin(2.6)
  • Kidney(2.5)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with TNIP1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNIP1 Gene

Orthologs for TNIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNIP1 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia TNIP1 34 35
  • 89.4 (n)
cow
(Bos Taurus)
Mammalia TNIP1 34 35
  • 88.66 (n)
mouse
(Mus musculus)
Mammalia Tnip1 34 16 35
  • 84.75 (n)
rat
(Rattus norvegicus)
Mammalia Tnip1 34
  • 84.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 80 (a)
OneToMany
-- 35
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TNIP1 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNIP1 34 35
  • 66.44 (n)
lizard
(Anolis carolinensis)
Reptilia TNIP1 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnip1 34
  • 59.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15972 34
zebrafish
(Danio rerio)
Actinopterygii tnip1 34 35
  • 58.26 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6096 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 13 (a)
OneToMany
Species where no ortholog for TNIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNIP1 Gene

ENSEMBL:
Gene Tree for TNIP1 (if available)
TreeFam:
Gene Tree for TNIP1 (if available)

Paralogs for TNIP1 Gene

Paralogs for TNIP1 Gene

(2) SIMAP similar genes for TNIP1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TNIP1: view

Variants for TNIP1 Gene

Sequence variations from dbSNP and Humsavar for TNIP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs117663772 Patients with gastrointestinal diffuse large cell lymphoma 151,049,883(+) TGGCC(A/G)CCCAG reference, missense
rs185683917 Patients with gastrointestinal diffuse large cell lymphoma 151,045,940(+) CTGCC(A/G)TCACA reference, missense
rs748495842 Patients with gastrointestinal diffuse large cell lymphoma 151,042,553(+) TTTCA(A/G)TCTTG reference, missense
VAR_067968 Patients with gastrointestinal diffuse large cell lymphoma
rs1000057796 -- 151,041,899(+) GCAGC(A/T)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNIP1 Gene

Variant ID Type Subtype PubMed ID
nsv462489 CNV loss 19166990
nsv526224 CNV gain 19592680
nsv600004 CNV loss 21841781

Variation tolerance for TNIP1 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.82; 73.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNIP1 Gene

Human Gene Mutation Database (HGMD)
TNIP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNIP1 Gene

Disorders for TNIP1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TNIP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
psoriatic arthritis
  • arthritis psoriatica
chronic intestinal vascular insufficiency
  • chronic mesenteric ischemia
hiv-1
  • aids, slow progression to
systemic lupus erythematosus
  • lupus nephritis
rheumatoid arthritis
  • rheumatoid arthritis, progression of
- elite association - COSMIC cancer census association via MalaCards
Search TNIP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TNIP1

Genetic Association Database (GAD)
TNIP1
Human Genome Epidemiology (HuGE) Navigator
TNIP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNIP1
genes like me logo Genes that share disorders with TNIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNIP1 Gene

Publications for TNIP1 Gene

  1. A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions. (PMID: 11090181) Gupta K. … Boeke J.D. (J. Virol. 2000) 2 3 4 22 64
  2. Identification and cloning of a novel cellular protein Naf1, Nef- associated factor 1, that increases cell surface CD4 expression. (PMID: 9923610) Fukushi M. … Yamamoto N. (FEBS Lett. 1999) 2 3 4 22 64
  3. A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. (PMID: 20010814) Ashida H. … Sasakawa C. (Nat. Cell Biol. 2010) 3 4 22 64
  4. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. (PMID: 19169254) Nair R.P. … Abecasis G.R. (Nat. Genet. 2009) 3 22 46 64
  5. Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis. (PMID: 19262574) Elder J.T. (Genes Immun. 2009) 3 22 46 64

Products for TNIP1 Gene

Sources for TNIP1 Gene

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