TNIP1 Gene
protein-coding GIFtS: 56
GCID: GC05M150409
|
|
TNFAIP3 interacting protein 1
| |
Aliases
for TNIP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TNFAIP3 Interacting Protein 11 2 | | Nef-Associated Factor 1 SNP2 | | NAF11 2 3 5 | | Nip40-13 | | ABIN-11 2 3 | | TNFAIP3-Interacting Protein 12 | | VAN1 2 3 | | Naf13 | | KIAA01131 3 5 | | Nip40-13 | | Virion-Associated Nuclear Shuttling Protein2 3 | | HVAN1 | | A20-Binding Inhibitor Of NF-Kappa-B Activation 12 3 | | Nef-Associated Factor 13 | | HIV-1 Nef-Interacting Protein2 3 | | |
Export aliases for TNIP1 gene to outside databasesPrevious GC identifers: GC05M150478 GC05M151006 GC05M150392 GC05M150438 GC05M150389 GC05M145555 |
Summaries
for TNIP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TNIP1:
This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through theregulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis,rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms havebeen found for this gene. (provided by RefSeq, Nov 2011)
UniProtKB/Swiss-Prot: TNIP1_HUMAN, Q15025Function: Interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene expressionby interfering with an RIP- or TRAF2-mediated transactivation signal; however, binding to A20/TNFAIP3 seems not to berequired for this function (By similarity). Inhibits NF-kappa-B activation by regulating A20/TNFAIP3-mediateddeubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-inducedERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcricption. Increasescell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positivelyregulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicatesbinding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated byassociation with SELPLG and dependent on phosohorylation by SRC-family kinases. Interacts with HIV-1 matrix proteinand is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclearlocalization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNAduring virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to itsproteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection
Gene Wiki entry for TNIP1
|
Genomic Views
for TNIP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TNIP1 gene promoter:
c-Fos p53 AP-1 ATF-2 c-Jun NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TNIP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNIP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q32-q33.1 Ensembl cytogenetic band: 5q33.1 HGNC cytogenetic band: 5q32-q33.1TNIP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M150409: view genomic region
(about GC identifiers)
Start:
|
150,409,506 bp from pter |
End:
|
150,473,138 bp from pter |
Size:
|
63,633 bases |
Orientation:
|
minus strand |
|
Proteins
for TNIP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TNIP1_HUMAN, Q15025 (See
protein sequence)Recommended Name: TNFAIP3-interacting protein 1 Size: 636 amino acids; 71864 Da
Subunit: Interacts with TNFAIP3 and IKBKG; facilitates TNFAIP3-mediated de-ubiquitination of NEMO/IKBKG. Interacts withHIV-1 matrix protein. Interacts with Shigella flexneri ipah9.8; the interaction promotes polyubiquitination of IKBKG.Interacts with polyubiquitin. Interacts with MAPK1, SELPLG and PIK3CD. Interacts with IKBKG (polyubiquitinated).Interacts with IRAK1 (polyubiquitinated). Interacts with MYD88; the interaction is indicative for participation in anactivated TLR-signaling complex (By similarity)
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner
Sequence caution: Sequence=AAB41438.1; Type=Frameshift; Positions=152, 154;
Secondary accessions: B7Z699 O76008 Q6N077 Q96EL9 Q99833 Q9H1J3Alternative splicing: 3 isoforms: Q15025-1 Q15025-2 Q15025-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TNIP1: NX_Q15025
Post-translational modifications:
Phosphorylation at Tyr-552 by SRC-family kinases recruits phosphoinositide-3-kinase (PI3K) PIK3CD:p85 heterodimer whichresults in integrin activation and leukocyte adhesion to activated endothelium during inflammation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15025
TNIP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (10 alternative transcripts):
NP_001239314.1 NP_001239315.1 NP_001239319.1 NP_001239320.1 NP_001239321.1 NP_001239322.1 NP_001245383.1 NP_001245384.1 NP_001245385.1 NP_006049.3
ENSEMBL proteins: ENSP00000429891 ENSP00000430739 ENSP00000317891 ENSP00000428243 ENSP00000428187 ENSP00000427854 ENSP00000430760 ENSP00000430971 ENSP00000429912 ENSP00000431105 ENSP00000428487 ENSP00000430279 ENSP00000428404 ENSP00000374029
Human Recombinant Protein Products for TNIP1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TNIP1 for ontologies About GeneDecksing
TNIP1 Antibody Products:
Assay Products for TNIP1: |
Protein
Domains /
Families
for TNIP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q15025 |
Function
for TNIP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TNIP1_HUMAN, Q15025Function: Interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene expressionby interfering with an RIP- or TRAF2-mediated transactivation signal; however, binding to A20/TNFAIP3 seems not to berequired for this function (By similarity). Inhibits NF-kappa-B activation by regulating A20/TNFAIP3-mediateddeubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-inducedERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcricption. Increasescell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positivelyregulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicatesbinding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated byassociation with SELPLG and dependent on phosohorylation by SRC-family kinases. Interacts with HIV-1 matrix proteinand is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclearlocalization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNAduring virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to itsproteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TNIP1 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for TNIP1:
13 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Tnip1):
TNIP1 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for TNIP1: Tnip1tm1.1Ama Tnip1tm1.2Pcoh
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TNIP1 (NM_006058) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNIP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNIP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNIP1 |
|
Pathways & Interactions
for TNIP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | 14-3-3 Induced Apoptosis | | | 2 | TNF-alpha/NF-kB Signaling Pathway | | | 3 | EGFR1 Signaling Pathway | | | 4 | NF-kappaB Signaling | | | 5 | Development_PDGF signaling via STATs and NF-kB | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNIP1
1 
Cell Signaling Technology (CST) Pathway for TNIP1
2  BioSystems Pathways for TNIP1
TNIP1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNIP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/42 Interacting proteins for TNIP1 (Q150251, 2, 3 ENSP000003178914) via UniProtKB, MINT, STRING, and/or I2D (see all 42)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| RBFOX1 | Q9NWB12, 3, ENSP000003091174 | MINT-2868198 I2D:
score=3 STRING: ENSP00000309117 | | MAGEB18 | Q96M611, 2, 3, ENSP000003145434 | EBI-357849,EBI-741835 MINT-67152 I2D:
score=5 STRING: ENSP00000314543 | | TNFAIP3 | P215802, 3, ENSP000002372894 | MINT-16057 I2D:
score=6 STRING: ENSP00000237289 | | IKBKG | Q9Y6K91, 3, ENSP000003586224 | EBI-357849,EBI-356130 I2D:
score=1 STRING: ENSP00000358622 | | CCNG1 | P519591, 3, ENSP000003446354 | EBI-357849,EBI-3905829 I2D:
score=1 STRING: ENSP00000344635 |
About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
TNIP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TNIP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TNIP1
Search CenterWatch for drugs/clinical trials and news about TNIP1
|
Transcripts
for TNIP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TNIP1 gene (10 alternative transcripts): NM_001252385.1 NM_001252386.1 NM_001252390.1 NM_001252391.1 NM_001252392.1 NM_001252393.1 NM_001258454.1 NM_001258455.1 NM_001258456.1 NM_006058.4 Unigene Cluster for TNIP1: TNFAIP3 interacting protein 1 Hs.355141 [show with all ESTs]Unigene Representative Sequence: NM_00125238518/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000520931(uc011dcn.2 uc010jhq.2 uc010jho.2 uc010jhp.2 uc010jhl.3)
ENST00000517504 ENST00000315050(uc010jhn.3 uc010jhm.3 uc003ltj.3 uc021ygb.1)
ENST00000523338(uc003ltk.3) ENST00000522574 ENST00000522226 ENST00000519339
ENST00000521591 ENST00000518977 ENST00000524280 ENST00000523200 ENST00000521423
ENST00000517329 ENST00000521782 ENST00000522100(uc010jhs.2) ENST00000520695
ENST00000521001 ENST00000522926
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TNIP1 (NM_006058) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNIP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNIP1 |
Additional cDNA sequence: AB177543.1 AB177544.1 AB252970.1 AB252971.1 AB252972.1 AB252973.1 AB252974.1 AB252975.1 AB252976.1 AB252977.1 AB252978.1 AB252979.1 AB252980.1 AB252981.1 AB252982.1 AJ011895.1 AJ011896.1 AK074400.1 AK097213.1 AK290999.1 AK298685.1 AK299975.1 AK303573.1 AY012155.1 BC007666.2 BC012133.1 BC014008.1 BX640647.1 D30755.2 U39403.1 U83844.1 21 DOTS entries: DT.97855065 DT.97801281 DT.100893305 DT.445731 DT.92452239 DT.91931834 DT.120879994 DT.95132682 DT.70102720 DT.91785801 DT.120879975 DT.120879992 DT.91948759 DT.95154078 DT.100893307 DT.100893320 DT.120880099 DT.40121435 DT.80100488 DT.95262177 DT.97855066 24/510 AceView cDNA sequences (see all 510): BU176581 BQ063186 BQ881631 U39403 BM992702 AI553786 AI866726 BU627706 F28688 BC012133 AA928428 BQ063886 BU153934 AA290755 BQ049924 AI687215 AW513504 BM696310 D30755 BQ642984 BQ924539 BG222341 AI673500 CR604663
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for TNIP1 (see all 14) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | · | 23c | · | 23d |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TNIP1
|
Expression
for TNIP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TNIP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACATAAATC
About this image
See TNIP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNIP1
SOURCE GeneReport for Unigene cluster: Hs.355141
UniProtKB/Swiss-Prot: TNIP1_HUMAN, Q15025Tissue specificity: Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and isweakly expressed in the brain
SABiosciences Custom PCR Arrays for TNIP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNIP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNIP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNIP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNIP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNIP1 |
Orthologs
for TNIP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TNIP1 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for TNIP1 (if available)
TreeFam Gene Tree for TNIP1 (if available) |
Paralogs
for TNIP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TNIP1 gene
- TNIP32
2 SIMAP similar genes for TNIP1 using alignment to 8 protein entries: TNIP1_HUMAN (see all proteins):NAF1 TNIP3
TNIP1 for paralogs About GeneDecksing
|
Genomic Variants
for TNIP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TNIP1 (150409506 - 150473138 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TNIP1: --
Human Gene Mutation Database (HGMD): TNIP1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNIP1 |
|
Disorders
/ Diseases
for TNIP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TNIP1 for disorders About GeneDecksing
OMIM gene information: 607714
OMIM disorders: --
13  diseases for TNIP1: About MalaCardssystemic lupus erythematosus psoriatic arthritis lupus erythematosus rheumatoid arthritis
arthritis diffuse large b-cell lymphoma chronic intestinal vascular insufficiency b-cell lymphomas
thrombocytopenia pulmonary disease psoriasis ataxia
immunodeficiency
2 diseases from the University of Copenhagen DISEASES database for TNIP1:Chronic intestinal vascular insufficiency Psoriasis 2 Novoseek disease relationships for TNIP1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
3.1 |
1 |
17016622 (1) |
| aids |
0 |
1 |
17016622 (1) |
Human Genome Epidemiology (HuGE) Navigator: TNIP1 (15 documents)
Export disorders for TNIP1 gene to outside databases
|
Publications
for TNIP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TNIP1 gene, integrated from 9 sources (see all 80):
(articles sorted by number of sources associating them with TNIP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions. (PubMed id 11090181)1, 2, 3, 9 Gupta K.... Boeke J.D. (2000)
- Identification and cloning of a novel cellular protein Naf1, Nef- associated factor 1, that increases cell surface CD4 expression. (PubMed id 9923610)1, 2, 3, 9 Fukushi M....Yamamoto N. (1999)
- ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB. (PubMed id 16684768)1, 2, 9 Mauro C....Leonardi A. (2006)
- A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling. (PubMed id 12220502)1, 2, 9 Zhang S....Tsuchida N. (2002)
- A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/ IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. (PubMed id 20010814)1, 2, 9 Ashida H....Sasakawa C. (2010)
- Polyubiquitin binding to ABIN1 is required to prevent autoimmunity. (PubMed id 21606507)1, 2 Nanda S.K....Cohen P. (2011)
- A20, ABIN-1/2, and CARD11 mutations and their prognos tic value in gastrointestinal diffuse large B-cell lymphoma. (PubMed id 21266526)1, 2 Dong G....Du M.Q. (2011)
- P-selectin primes leukocyte integrin activation during inflammation. (PubMed id 17632516)1, 2 Wang H.B.... Geng J.G. (2007)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for TNIP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TNIP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TNIP1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TNIP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TNIP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TNIP1 gene:
Search GeneIP for patents involving TNIP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TNIP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TNIP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNIP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNIP1 | | | OriGene Protein Over-expression Lysate for TNIP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TNIP1 | | OriGene 3'-UTR Clone for TNIP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNIP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TNIP1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TNIP1 | | OriGene Custom Protein Services for TNIP1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TNIP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNIP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNIP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNIP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNIP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNIP1 |
| |
 |  |  |  | |
| | Antibodies & Assays for TNIP1 |
| | | | Search Tocris compounds for TNIP1 |
| |  |  |  |  | | | | | | Recombinant Protein for TNIP1 |
|
 |
 |
 |
 | | | TNIP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNIP1 |
|  |  |  |  | | | | ThermoFisher Antibodies for TNIP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNIP1 |
| |  | |
|
|
|
