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Aliases for TNIP1 Gene

Aliases for TNIP1 Gene

  • TNFAIP3 Interacting Protein 1 2 3
  • NAF1 3 4 6
  • A20-Binding Inhibitor Of NF-Kappa-B Activation 1 3 4
  • Virion-Associated Nuclear Shuttling Protein 3 4
  • HIV-1 Nef-Interacting Protein 3 4
  • Nef-Associated Factor 1 SNP 2 3
  • KIAA0113 4 6
  • Nip40-1 3 4
  • ABIN-1 3 4
  • VAN 3 4
  • Virion-Associated Nuclear-Shuttling Protein 2
  • TNFAIP3-Interacting Protein 1 3
  • Nef-Associated Factor 1 4
  • HVAN 4

External Ids for TNIP1 Gene

Previous GeneCards Identifiers for TNIP1 Gene

  • GC05M150478
  • GC05M151006
  • GC05M150392
  • GC05M150438
  • GC05M150389
  • GC05M145555
  • GC05M150409

Summaries for TNIP1 Gene

Entrez Gene Summary for TNIP1 Gene

  • This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for TNIP1 Gene

TNIP1 (TNFAIP3 Interacting Protein 1) is a Protein Coding gene. Diseases associated with TNIP1 include chronic intestinal vascular insufficiency and psoriatic arthritis. Among its related pathways are Immune response IL-23 signaling pathway and EGFR1 Signaling Pathway. GO annotations related to this gene include ubiquitin-specific protease activity and mitogen-activated protein kinase binding. An important paralog of this gene is TNIP3.

UniProtKB/Swiss-Prot for TNIP1 Gene

  • Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.

Gene Wiki entry for TNIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNIP1 Gene

Genomics for TNIP1 Gene

Regulatory Elements for TNIP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNIP1 Gene

Start:
151,029,943 bp from pter
End:
151,093,577 bp from pter
Size:
63,635 bases
Orientation:
Minus strand

Genomic View for TNIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNIP1 Gene

Proteins for TNIP1 Gene

  • Protein details for TNIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15025-TNIP1_HUMAN
    Recommended name:
    TNFAIP3-interacting protein 1
    Protein Accession:
    Q15025
    Secondary Accessions:
    • A4F1W8
    • A4F1W9
    • A4F1X2
    • A4F1X4
    • A4F1X5
    • A4F1X6
    • A4F1X7
    • A4F1X9
    • B7Z699
    • E7EPY1
    • E7ET96
    • O76008
    • Q05KP3
    • Q05KP4
    • Q6N077
    • Q96EL9
    • Q99833
    • Q9H1J3

    Protein attributes for TNIP1 Gene

    Size:
    636 amino acids
    Molecular mass:
    71864 Da
    Quaternary structure:
    • Interacts with TNFAIP3 and IKBKG (polyubiquitinated); facilitates TNFAIP3-mediated de-ubiquitination of NEMO/IKBKG. Interacts with polyubiquitin. Interacts with MAPK1, SELPLG and PIK3CD. Interacts with IRAK1 (polyubiquitinated). Interacts with MYD88; the interaction is indicative for participation in an activated TLR-signaling complex. Interacts with HIV-1 matrix protein. Interacts with Shigella flexneri ipah9.8; the interaction promotes polyubiquitination of IKBKG.
    SequenceCaution:
    • Sequence=AAB41438.1; Type=Frameshift; Positions=152, 154; Evidence={ECO:0000305};

    Alternative splice isoforms for TNIP1 Gene

neXtProt entry for TNIP1 Gene

Proteomics data for TNIP1 Gene at MOPED

Post-translational modifications for TNIP1 Gene

  • Phosphorylation at Tyr-552 by SRC-family kinases recruits phosphoinositide-3-kinase (PI3K) PIK3CD:p85 heterodimer which results in integrin activation and leukocyte adhesion to activated endothelium during inflammation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TNIP1 (TNIP1)

No data available for DME Specific Peptides for TNIP1 Gene

Domains for TNIP1 Gene

Protein Domains for TNIP1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TNIP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNIP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TNIP1 Gene

Function for TNIP1 Gene

Molecular function for TNIP1 Gene

UniProtKB/Swiss-Prot Function: Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.

Gene Ontology (GO) - Molecular Function for TNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 contributes_to ubiquitin-specific protease activity IDA 16684768
GO:0005488 binding --
GO:0005515 protein binding IPI 15474016
GO:0051019 mitogen-activated protein kinase binding IDA 12220502
genes like me logo Genes that share ontologies with TNIP1: view
genes like me logo Genes that share phenotypes with TNIP1: view

Animal Models for TNIP1 Gene

MGI Knock Outs for TNIP1:

Animal Model Products

CRISPR Products

miRNA for TNIP1 Gene

miRTarBase miRNAs that target TNIP1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNIP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TNIP1 Gene

Localization for TNIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNIP1 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNIP1 Gene COMPARTMENTS Subcellular localization image for TNIP1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 9923610
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TNIP1: view

Pathways for TNIP1 Gene

genes like me logo Genes that share pathways with TNIP1: view

Pathways by source for TNIP1 Gene

2 Qiagen pathways for TNIP1 Gene
1 Cell Signaling Technology pathway for TNIP1 Gene
2 BioSystems pathways for TNIP1 Gene

Gene Ontology (GO) - Biological Process for TNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002755 MyD88-dependent toll-like receptor signaling pathway ISS --
GO:0006412 translation TAS 9923610
GO:0006952 defense response TAS 9923610
GO:0006954 inflammatory response IEA --
GO:0007159 leukocyte cell-cell adhesion IMP 17632516
genes like me logo Genes that share ontologies with TNIP1: view

Transcripts for TNIP1 Gene

Unigene Clusters for TNIP1 Gene

TNFAIP3 interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNIP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNIP1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1: -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c · 23d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10: -
SP11: - -
SP12:
SP13:
SP14:

Relevant External Links for TNIP1 Gene

GeneLoc Exon Structure for
TNIP1
ECgene alternative splicing isoforms for
TNIP1

Expression for TNIP1 Gene

mRNA expression in normal human tissues for TNIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNIP1 Gene

This gene is overexpressed in Whole Blood (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNIP1 Gene

SOURCE GeneReport for Unigene cluster for TNIP1 Gene Hs.355141

mRNA Expression by UniProt/SwissProt for TNIP1 Gene

Q15025-TNIP1_HUMAN
Tissue specificity: Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed. Expression of isoform 1 and isoform 7 increases in leukemic cells.
genes like me logo Genes that share expressions with TNIP1: view

In Situ Assay Products

Orthologs for TNIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNIP1 35
  • 99.74 (n)
  • 99.53 (a)
TNIP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNIP1 35
  • 88.66 (n)
  • 87.48 (a)
TNIP1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNIP1 35
  • 89.4 (n)
  • 89.72 (a)
TNIP1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnip1 35
  • 84.75 (n)
  • 84.7 (a)
Tnip1 16
Tnip1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNIP1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tnip1 35
  • 84.17 (n)
  • 83.28 (a)
chicken
(Gallus gallus)
Aves TNIP1 35
  • 66.44 (n)
  • 58.66 (a)
TNIP1 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNIP1 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15972 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tnip1 35
  • 59.72 (n)
  • 55.73 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6096 35
zebrafish
(Danio rerio)
Actinopterygii tnip1 35
  • 58.26 (n)
  • 52.24 (a)
tnip1 36
  • 42 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 13 (a)
OneToMany
Species with no ortholog for TNIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNIP1 Gene

ENSEMBL:
Gene Tree for TNIP1 (if available)
TreeFam:
Gene Tree for TNIP1 (if available)

Paralogs for TNIP1 Gene

Paralogs for TNIP1 Gene

Selected SIMAP similar genes for TNIP1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TNIP1: view

Variants for TNIP1 Gene

Sequence variations from dbSNP and Humsavar for TNIP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs3924 -- 151,030,574(+) CTGGT(A/G)TACAA utr-variant-3-prime
rs736775 -- 151,029,787(+) CCCGG(C/T)TGCCC downstream-variant-500B
rs869594 -- 151,053,480(-) CACTT(C/G)CACTC intron-variant
rs871269 -- 151,052,827(+) ACCAT(C/T)CTCTT intron-variant
rs888989 -- 151,051,469(+) AGTTC(C/T)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNIP1 Gene

Variant ID Type Subtype PubMed ID
nsv526224 CNV Gain 19592680
nsv462489 CNV Loss 19166990

Relevant External Links for TNIP1 Gene

HapMap Linkage Disequilibrium report
TNIP1
Human Gene Mutation Database (HGMD)
TNIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNIP1 Gene

Disorders for TNIP1 Gene

(2) University of Copenhagen DISEASES for TNIP1 Gene

(2) Novoseek inferred disease relationships for TNIP1 Gene

Disease -log(P) Hits PubMed IDs
tumors 3.1 1
aids 0 1

Relevant External Links for TNIP1

Genetic Association Database (GAD)
TNIP1
Human Genome Epidemiology (HuGE) Navigator
TNIP1
genes like me logo Genes that share disorders with TNIP1: view

No data available for UniProtKB/Swiss-Prot for TNIP1 Gene

Publications for TNIP1 Gene

  1. Identification and cloning of a novel cellular protein Naf1, Nef- associated factor 1, that increases cell surface CD4 expression. (PMID: 9923610) Fukushi M. … Yamamoto N. (FEBS Lett. 1999) 2 3 4 23
  2. A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions. (PMID: 11090181) Gupta K. … Boeke J.D. (J. Virol. 2000) 2 3 4 23
  3. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. (PMID: 19169254) Nair R.P. … Abecasis G.R. (Nat. Genet. 2009) 3 23 48
  4. Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis. (PMID: 19262574) Elder J.T. (Genes Immun. 2009) 3 23 48
  5. A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling. (PMID: 12220502) Zhang S. … Tsuchida N. (Biochem. Biophys. Res. Commun. 2002) 3 4 23

Products for TNIP1 Gene

Sources for TNIP1 Gene

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