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TNIP1 Gene

protein-coding   GIFtS: 62
GCID: GC05M150409

TNFAIP3 Interacting Protein 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TNFAIP3 Interacting Protein 11 2     KIAA01133 5
NAF12 3 5     Virion-Associated Nuclear-Shuttling Protein1
Nef-Associated Factor 1 SNP1 2     nip40-12
Virion-Associated Nuclear Shuttling Protein2 3     TNFAIP3-Interacting Protein 12
ABIN-12 3     Naf13
VAN2 3     Nip40-13
A20-Binding Inhibitor Of NF-Kappa-B Activation 12 3     hVAN3
HIV-1 Nef-Interacting Protein2 3     Nef-Associated Factor 13

External Ids:    HGNC: 169031   Entrez Gene: 103182   Ensembl: ENSG000001459017   OMIM: 6077145   UniProtKB: Q150253   

Export aliases for TNIP1 gene to outside databases

Previous GC identifers: GC05M150478 GC05M151006 GC05M150392 GC05M150438 GC05M150389 GC05M145555


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNIP1 Gene:
This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the
regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic
arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for TNIP1 Gene:
TNIP1 (TNFAIP3 interacting protein 1) is a protein-coding gene. Diseases associated with TNIP1 include chronic intestinal vascular insufficiency, and psoriatic arthritis. GO annotations related to this gene include ubiquitin-specific protease activity and mitogen-activated protein kinase binding. An important paralog of this gene is TNIP3.

UniProtKB/Swiss-Prot: TNIP1_HUMAN, Q15025
Function: Interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene
expression by interfering with an RIP- or TRAF2-mediated transactivation signal; however, binding to A20/TNFAIP3
seems not to be required for this function (By similarity). Inhibits NF-kappa-B activation by regulating
A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in
regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and
MAPK1-dependent transcricption. Increases cell surface CD4(T4) antigen expression. Involved in the
anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in
the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin
activation during inflammation; this function is mediated by association with SELPLG and dependent on
phosohorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and
overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of
PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In
case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p
which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is
perturbing NF-kappa-B activation during bacterial infection

Gene Wiki entry for TNIP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNIP1 gene promoter:
         c-Fos   p53   AP-1   ATF-2   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNIP1 promoter sequence
   Search Chromatin IP Primers for TNIP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32-q33.1   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q32-q33.1

TNIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNIP1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M150409:  view genomic region     (about GC identifiers)

Start:
150,409,506 bp from pter      End:
150,473,138 bp from pter
Size:
63,633 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TNIP1_HUMAN, Q15025 (See protein sequence)
Recommended Name: TNFAIP3-interacting protein 1  
Size: 636 amino acids; 71864 Da
Subunit: Interacts with TNFAIP3 and IKBKG; facilitates TNFAIP3-mediated de-ubiquitination of NEMO/IKBKG. Interacts
with HIV-1 matrix protein. Interacts with Shigella flexneri ipah9.8; the interaction promotes polyubiquitination
of IKBKG. Interacts with polyubiquitin. Interacts with MAPK1, SELPLG and PIK3CD. Interacts with IKBKG
(polyubiquitinated). Interacts with IRAK1 (polyubiquitinated). Interacts with MYD88; the interaction is
indicative for participation in an activated TLR-signaling complex (By similarity)
Sequence caution: Sequence=AAB41438.1; Type=Frameshift; Positions=152, 154;
Secondary accessions: B7Z699 O76008 Q6N077 Q96EL9 Q99833 Q9H1J3
Alternative splicing: 3 isoforms:  Q15025-1   Q15025-2   Q15025-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNIP1: NX_Q15025

Explore proteomics data for TNIP1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Tyr-552 by SRC-family kinases recruits phosphoinositide-3-kinase (PI3K) PIK3CD:p85 heterodimer
    which results in integrin activation and leukocyte adhesion to activated endothelium during inflammation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TNIP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (10 alternative transcripts): 
    NP_001239314.1  NP_001239315.1  NP_001239319.1  NP_001239320.1  NP_001239321.1  NP_001239322.1  NP_001245383.1  NP_001245384.1  
    NP_001245385.1  NP_006049.3  

    ENSEMBL proteins: 
     ENSP00000429891   ENSP00000430739   ENSP00000317891   ENSP00000428243   ENSP00000428187  
     ENSP00000427854   ENSP00000430760   ENSP00000430971   ENSP00000429912   ENSP00000431105  
     ENSP00000428487   ENSP00000430279   ENSP00000428404   ENSP00000374029  

    TNIP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for TNIP1
    OriGene Protein Over-expression Lysate for TNIP1
    OriGene MassSpec for TNIP1
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    GenScript Custom Purified and Recombinant Proteins Services for TNIP1
    Novus Biologicals TNIP1 Proteins
    Novus Biologicals TNIP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TNIP1
    Cloud-Clone Corp. Proteins for TNIP1

    TNIP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TNIP1 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TNIP1
    Novus Biologicals TNIP1 Antibodies
    Abcam antibodies for TNIP1
    Cloud-Clone Corp. Antibodies for TNIP1
    ThermoFisher Antibodies for TNIP1
    LSBio Antibodies in human, mouse, rat for TNIP1

    TNIP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TNIP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TNIP1
    Cloud-Clone Corp. CLIAs for TNIP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q15025


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNIP1_HUMAN, Q15025
    Function: Interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene
    expression by interfering with an RIP- or TRAF2-mediated transactivation signal; however, binding to A20/TNFAIP3
    seems not to be required for this function (By similarity). Inhibits NF-kappa-B activation by regulating
    A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in
    regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and
    MAPK1-dependent transcricption. Increases cell surface CD4(T4) antigen expression. Involved in the
    anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in
    the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin
    activation during inflammation; this function is mediated by association with SELPLG and dependent on
    phosohorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and
    overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of
    PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In
    case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p
    which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is
    perturbing NF-kappa-B activation during bacterial infection

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004843contributes to ubiquitin-specific protease activity IDA16684768
    GO:0005488binding ----
    GO:0005515protein binding IPI15474016
    GO:0051019mitogen-activated protein kinase binding IDA12220502
         
    TNIP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNIP1:
     Decreased nuclei size in G2M  Upregulation of NF-kappaB path 

         13 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Tnip1):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  no phenotypic analysis  renal/urinary system 

    TNIP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TNIP1: Tnip1tm1.1Ama Tnip1tm1.2Pcoh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNIP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNIP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNIP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNIP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TNIP1:
    hsa-mir-324-3p (MIRT042899), hsa-mir-221-3p (MIRT024151), hsa-mir-181a-5p (MIRT047340)

    Block miRNA regulation of human, mouse, rat TNIP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNIP1 (see all 23):
    hsa-miR-30c hsa-miR-3200-5p hsa-miR-517a hsa-miR-517c hsa-miR-548v hsa-miR-486-3p hsa-miR-30d hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmidTNIP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TNIP1
    Predesigned siRNA for gene silencing in human, mouse, rat TNIP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TNIP1

    Clone
    Products:
         
    OriGene clones in human, mouse for TNIP1 (see all 6)
    OriGene ORF clones in mouse, rat for TNIP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNIP1 (NM_006058)
    Sino Biological Human cDNA Clone for TNIP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNIP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNIP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TNIP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TNIP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNIP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNIP1_HUMAN, Q15025: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent
    manner
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular TAS9923610
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    TNIP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNIP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis (KEGG)
    14-3-3 Induced Apoptosis0.37
    2Immune response IL 23 signaling pathway
    Angiopoietin-TIE2 Signaling0.36
    3TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    4NF-kappaB Signaling
    NF-kappaB Signaling
    5EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNIP1
        14-3-3 Induced Apoptosis
    Angiopoietin-TIE2 Signaling

    1 Cell Signaling Technology (CST) Pathway for TNIP1
        NF-kappaB Signaling

    2 BioSystems Pathways for TNIP1
        EGFR1 Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway




    TNIP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TNIP1
    Interactions:

        GeneGlobe Interaction Network for TNIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNIP1 (Q150251, 2, 3 ENSP000003178914) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBFOX1Q9NWB12, 3, ENSP000003091174MINT-2868198 I2D: score=3 STRING: ENSP00000309117
    ENSG00000228321P013753, ENSP000003928584I2D: score=1 STRING: ENSP00000392858
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002755MyD88-dependent toll-like receptor signaling pathway ISS--
    GO:0006412translation TAS9923610
    GO:0006952defense response TAS9923610
    GO:0006954inflammatory response IEA--
    GO:0007159leukocyte cell-cell adhesion IMP17632516

    TNIP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNIP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TNIP1 gene (10 alternative transcripts): 
    NM_001252385.1  NM_001252386.1  NM_001252390.1  NM_001252391.1  NM_001252392.1  NM_001252393.1  NM_001258454.1  NM_001258455.1  
    NM_001258456.1  NM_006058.4  

    Unigene Cluster for TNIP1:

    TNFAIP3 interacting protein 1
    Hs.355141  [show with all ESTs]
    Unigene Representative Sequence: NM_001252385
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000520931(uc011dcn.2 uc010jhq.2 uc010jho.2 uc010jhp.2 uc010jhl.3)
    ENST00000517504 ENST00000315050(uc010jhn.3 uc010jhm.3 uc003ltj.3 uc021ygb.1)
    ENST00000523338(uc003ltk.3) ENST00000522574 ENST00000522226 ENST00000519339
    ENST00000521591 ENST00000518977 ENST00000524280 ENST00000523200 ENST00000521423
    ENST00000517329 ENST00000521782 ENST00000522100(uc010jhs.2) ENST00000520695
    ENST00000521001 ENST00000522926
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TNIP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNIP1 (see all 23):
    hsa-miR-30c hsa-miR-3200-5p hsa-miR-517a hsa-miR-517c hsa-miR-548v hsa-miR-486-3p hsa-miR-30d hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmidTNIP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TNIP1
    Predesigned siRNA for gene silencing in human, mouse, rat TNIP1
    Clone
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    OriGene clones in human, mouse for TNIP1 (see all 6)
    OriGene ORF clones in mouse, rat for TNIP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNIP1 (NM_006058)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNIP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNIP1
    Primer
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    OriGene qPCR primer pairs and template standards for TNIP1
    OriGene qSTAR qPCR primer pairs in human, mouse for TNIP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNIP1
      QuantiTect SYBR Green Assays in human, mouse, rat TNIP1
      QuantiFast Probe-based Assays in human, mouse, rat TNIP1

    Additional mRNA sequence: 

    AB177543.1 AB177544.1 AB252970.1 AB252971.1 AB252972.1 AB252973.1 AB252974.1 AB252975.1 
    AB252976.1 AB252977.1 AB252978.1 AB252979.1 AB252980.1 AB252981.1 AB252982.1 AJ011895.1 
    AJ011896.1 AK074400.1 AK097213.1 AK290999.1 AK298685.1 AK299975.1 AK303573.1 AY012155.1 
    BC007666.2 BC012133.1 BC014008.1 BX640647.1 D30755.2 U39403.1 U83844.1 

    21 DOTS entries:

    DT.97855065  DT.97801281  DT.100893305  DT.445731  DT.92452239  DT.91931834  DT.120879994  DT.95132682 
    DT.70102720  DT.91785801  DT.120879975  DT.120879992  DT.91948759  DT.95154078  DT.100893307  DT.100893320 
    DT.120880099  DT.40121435  DT.80100488  DT.95262177  DT.97855066 

    Selected AceView cDNA sequences (see all 510):

    AI202394 BU629243 BQ049924 BQ049151 AI801511 AA362332 BM981730 BQ026759 
    AI687215 AI673500 AI554279 BC014008 BI764285 BU153934 CA448470 BM664684 
    BM455569 BG151511 BQ940980 AA027044 BM981899 AI167141 BU786156 BX640647 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TNIP1 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
    SP1:                                                                                                              -                                             
    SP2:              -     -     -     -     -     -     -     -                                                                                                   
    SP3:              -     -     -     -     -     -                                                                                                               
    SP4:                                      -     -                                                                                                               
    SP5:                                      -     -     -     -                                                                                                   

    ExUns: 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c · 23d
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for TNIP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACATAAATC
    TNIP1 Expression
    About this image


    TNIP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Kidney (Urinary System)
     
     Lung (Respiratory System)
     
     Adipose (Muscoskeletal System)
    TNIP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNIP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.355141

    UniProtKB/Swiss-Prot: TNIP1_HUMAN, Q15025
    Tissue specificity: Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle,
    and is weakly expressed in the brain

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNIP1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnip11 , 5 TNFAIP3 interacting protein 11, 5 84.75(n)1
    84.7(a)1
      11 (32.13 cM)5
    577831  NM_001199275.21  NP_001186204.11 
     549107875 
    chicken
    (Gallus gallus)
    Aves TNIP11 TNFAIP3 interacting protein 1 66.44(n)
    58.66(a)
      100858009  XM_004944943.1  XP_004945000.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNIP16
    TNFAIP3 interacting protein 1
    58(a)
    1 ↔ 1
    2(138263469-138302996)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.159722 Xenopus laevis transcribed sequence with weak similarity more 72.61(n)    BJ031153.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tnip11 TNFAIP3 interacting protein 1 58.26(n)
    52.24(a)
      449958  NM_001079952.1  NP_001073421.1 


    ENSEMBL Gene Tree for TNIP1 (if available)
    TreeFam Gene Tree for TNIP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNIP1 gene
    TNIP32  
    2 SIMAP similar genes for TNIP1 using alignment to 8 protein entries:     TNIP1_HUMAN (see all proteins):
    NAF1    TNIP3

    TNIP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNIP1 (see all 1351)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1856839171,2,,4
    CPatients with gastrointestinal diffuse large cell lymphoma4 --150701618(+) CTGCCA/GTCACA 20 T M mis10--------
    rs1176637721,2,,4
    C,FPatients with gastrointestinal diffuse large cell lymphoma4 --150705562(+) TGGCCG/ACCCAG 20 /R /W mis13Minor allele frequency- A:0.00EA NA EU 5995
    VAR_0679684
    Patients with gastrointestinal diffuse large cell lymphoma4--see VAR_0679682 E K mis40--------
    VAR_0679674
    Patients with gastrointestinal diffuse large cell lymphoma4--see VAR_0679672 I T mis40--------
    rs113755071,2
    C--150412689(+) AAAAAA/-AAAAA 10 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs38403121,2
    C--150417987(-) GCCCTG/-GGTGG 10 -- int11Minor allele frequency- -:0.50NA 2
    rs1999408161,2
    C--150424659(+) TTTTT-/TGAGAT 10 -- int10--------
    rs350150811,2
    C--150427966(+) ATTTTT/-ACAGA 10 -- int11Minor allele frequency- -:0.00NA 2
    rs577016641,2
    C--150429245(+) AAAAA-/ACACGT 10 -- int10--------
    rs113907881,2
    C--150432680(+) TTTTTT/-TTTTT 10 -- int1 trp31Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for TNIP1 (150409506 - 150473138 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TNIP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv462489CNV Loss19166990
    nsv526224CNV Gain19592680

    Human Gene Mutation Database (HGMD): TNIP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNIP1
    DNA2.0 Custom Variant and Variant Library Synthesis for TNIP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607714    OMIM disorders: --

    17 diseases for TNIP1:    
    About MalaCards
    chronic intestinal vascular insufficiency    psoriatic arthritis    hiv-1    5q- syndrome
    arthritis    systemic lupus erythematosus    lupus erythematosus    rheumatoid arthritis
    myasthenia gravis    thrombocytopenia    diffuse large b-cell lymphoma    lung cancer susceptibility
    b-cell lymphomas    psoriasis    inflammatory bowel disease    ataxia
    lung cancer

    2 diseases from the University of Copenhagen DISEASES database for TNIP1:
    Chronic intestinal vascular insufficiency     Psoriasis

    TNIP1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TNIP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 3.1 1 17016622 (1)
    aids 0 1 17016622 (1)

    Genetic Association Database (GAD): TNIP1
    Human Genome Epidemiology (HuGE) Navigator: TNIP1 (15 documents)

    Export disorders for TNIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNIP1 gene, integrated from 10 sources (see all 92):
    (articles sorted by number of sources associating them with TNIP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions. (PubMed id 11090181)1, 2, 3, 9 Gupta K.... Boeke J.D. (J. Virol. 2000)
    2. Identification and cloning of a novel cellular protein Naf1, Nef- associated factor 1, that increases cell surface CD4 expression. (PubMed id 9923610)1, 2, 3, 9 Fukushi M....Yamamoto N. (FEBS Lett. 1999)
    3. ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB. (PubMed id 16684768)1, 2, 9 Mauro C.... Leonardi A. (J. Biol. Chem. 2006)
    4. Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis. (PubMed id 19262574)1, 4, 9 Elder J.T. (Genes Immun. 2009)
    5. A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling. (PubMed id 12220502)1, 2, 9 Zhang S....Tsuchida N. (Biochem. Biophys. Res. Commun. 2002)
    6. A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. (PubMed id 20010814)1, 2, 9 Ashida H.... Sasakawa C. (Nat. Cell Biol. 2010)
    7. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. (PubMed id 19169254)1, 4, 9 Nair R.P....Abecasis G.R. (Nat. Genet. 2009)
    8. Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis. (PubMed id 21750679)1, 4 Allanore Y....Martinez M. (PLoS Genet. 2011)
    9. Polyubiquitin binding to ABIN1 is required to prevent autoimmunity. (PubMed id 21606507)1, 2 Nanda S.K.... Cohen P. (J. Exp. Med. 2011)
    10. A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma. (PubMed id 21266526)1, 2 Dong G.... Du M.Q. (Clin. Cancer Res. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10318 HGNC: 16903 AceView: TNIP1 Ensembl:ENSG00000145901 euGenes: HUgn10318
    ECgene: TNIP1 H-InvDB: TNIP1

    (According to HUGE)
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    HUGE: KIAA0113

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNIP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNIP1 gene:
    Search GeneIP for patents involving TNIP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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