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TNIK Gene

protein-coding   GIFtS: 65
GCID: GC03M170779

TRAF2 And NCK Interacting Kinase

  Search for TNIK
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TRAF2 And NCK Interacting Kinase1 2
EC 2.7.11.13 8
KIAA05513 5
TRAF2 And NCK-Interacting Protein Kinase2
EC 2.7.118

External Ids:    HGNC: 307651   Entrez Gene: 230432   Ensembl: ENSG000001543107   OMIM: 6100055   UniProtKB: Q9UKE53   

Export aliases for TNIK gene to outside databases

Previous GC identifers: GC03M172102 GC03M172262 GC03M168150


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNIK Gene:
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal
GCK domain that serves a regulatory function (Fu et al., 1999 (PubMed 10521462)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TNIK Gene:
TNIK (TRAF2 and NCK interacting kinase) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and small GTPase regulator activity. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: TNIK_HUMAN, Q9UKE5
Function: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to
promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2.
Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress.
Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and
arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate
cell spreading. Phosphorylates SMAD1 on Thr-322

Gene Wiki entry for TNIK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNIK gene promoter:
         Egr-3   Sox5   Spz1   AP-1   ATF-2   CUTL1   LCR-F1   Egr-4   IRF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNIK promoter sequence
   Search Chromatin IP Primers for TNIK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNIK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.31   Ensembl cytogenetic band:  3q26.31   HGNC cytogenetic band: 3q26.31

TNIK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNIK gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M170779:  view genomic region     (about GC identifiers)

Start:
170,779,128 bp from pter      End:
171,178,197 bp from pter
Size:
399,070 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TNIK_HUMAN, Q9UKE5 (See protein sequence)
Recommended Name: TRAF2 and NCK-interacting protein kinase  
Size: 1360 amino acids; 154943 Da
Subunit: Interacts (via the CNH domain) with RAP2A (GTP-bound form preferentially); the interaction is direct and
required for the activation of TNIK by RAP2A. Interacts with NEDD4; recruits RAP2A to NEDD4. Interacts with TRAF2
and NCK. Interacts with TCF7L2/TCF4 and CTNNB1; the interaction is direct. Interacts with TANC1
Sequence caution: Sequence=BAA25477.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for TNIK:
2X7F (3D)    
Secondary accessions: A7E2A3 A8K4U1 D3DNQ6 O60298 Q8WUY7 Q9UKD8 Q9UKD9 Q9UKE0 Q9UKE1 Q9UKE2
Q9UKE3 Q9UKE4
Alternative splicing: 8 isoforms:  Q9UKE5-1   Q9UKE5-2   Q9UKE5-3   Q9UKE5-4   Q9UKE5-5   Q9UKE5-6   Q9UKE5-7   Q9UKE5-8   

Explore the universe of human proteins at neXtProt for TNIK: NX_Q9UKE5

Explore proteomics data for TNIK at MOPED

Post-translational modifications: 

  • Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction1
  • Ubiquitination2 at Lys46, Lys1319
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TNIK (Q9UKE5) (see all 31)
     RNDKVFF  PFIRDQP  WMAPEVI  MEFCGAGS 


    See TNIK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001155032.1  NP_001155033.1  NP_001155034.1  NP_001155035.1  NP_001155036.1  NP_001155037.1  NP_001155038.1  NP_055843.1  

    ENSEMBL proteins: 
     ENSP00000399511   ENSP00000345352   ENSP00000284483   ENSP00000418156   ENSP00000349880  
     ENSP00000418916   ENSP00000418378   ENSP00000419990   ENSP00000417338   ENSP00000419308  
     ENSP00000358332   ENSP00000443278  
    Reactome Protein details: Q9UKE5

    TNIK Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TNIK
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TNIK
    GenScript Custom Purified and Recombinant Proteins Services for TNIK
    Novus Biologicals TNIK Proteins
    Novus Biologicals TNIK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNIK

     
    Search eBioscience for Proteins for TNIK 

    TNIK Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals TNIK Antibodies
    Abcam antibodies for TNIK
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    ThermoFisher Antibodies for TNIK
    LSBio Antibodies in human, mouse, rat for TNIK

    TNIK Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TNIK
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TNIK
    Cloud-Clone Corp. CLIAs for TNIK
    Search eBioscience for ELISAs for TNIK 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: TRAF2 and NCK interacting kinase
    MSN subfamily

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR001180 Citron
     IPR028560 TNIK
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UKE5

    ProtoNet protein and cluster: Q9UKE5

    1 Blocks protein domain: IPB001180 Citron-like

    UniProtKB/Swiss-Prot: TNIK_HUMAN, Q9UKE5
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CNH domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TNIK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNIK_HUMAN, Q9UKE5
    Function: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to
    promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2.
    Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress.
    Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and
    arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate
    cell spreading. Phosphorylates SMAD1 on Thr-322
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA10521462
    GO:0004702receptor signaling protein serine/threonine kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005083small GTPase regulator activity IEA--
         
    Find genes that share ontologies with TNIK           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for TNIK:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased telomerase activity  Gemcitabine induced cell-death 
     Increased colony dispersion (i  Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tnik):
     adipose tissue  behavior/neurological  cellular  growth/size/body  homeostasis/metabolism 
     nervous system  skeleton 

    Find genes that share phenotypes with TNIK           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNIK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNIK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNIK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNIK

    miRNA
    Products:
        
    miRTarBase miRNAs that target TNIK:
    hsa-mir-335-5p (MIRT017299)

    Block miRNA regulation of human, mouse, rat TNIK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNIK (see all 15):
    hsa-miR-1197 hsa-miR-3166 hsa-miR-575 hsa-miR-1324 hsa-miR-138-2* hsa-miR-218 hsa-miR-942 hsa-miR-567
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TNIK
    Predesigned siRNA for gene silencing in human, mouse, rat TNIK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TNIK

    Clone
    Products:
         
    OriGene clones in human, mouse for TNIK (see all 50)
    OriGene ORF clones in mouse, rat for TNIK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): TNIK (NM_015028)
    Sino Biological Human cDNA Clone for TNIK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNIK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNIK
    Addgene plasmids for TNIK 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TNIK 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNIK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNIK_HUMAN, Q9UKE5: Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with
    recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    endosome5
    nucleus5
    cytosol3
    extracellular1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19816403
    GO:0005737cytoplasm IDA15342639
    GO:0005856cytoskeleton IDA15342639
    GO:0055037recycling endosome IEA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with TNIK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNIK About    
    See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    2TNF receptor signaling pathway
    TNF receptor signaling pathway
    3Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    Find genes that share SuperPaths with TNIK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for TNIK
        TNF receptor signaling pathway
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    1 Reactome Pathway for TNIK
        Oxidative Stress Induced Senescence


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TNIK
    Interactions:

        GeneGlobe Interaction Network for TNIK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TNIK (Q9UKE51, 2, 3 ENSP000003995114) via UniProtKB, MINT, STRING, and/or I2D (see all 171)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCF7L2Q9NQB01, 2, 3, ENSP000003584044EBI-1051794,EBI-924724 MINT-7952375 MINT-7952429 MINT-7952386 I2D: score=1 STRING: ENSP00000358404
    CTNNB1P352221, 2, 3, ENSP000003444564EBI-1051794,EBI-491549 MINT-7952397 MINT-7952417 MINT-7952375 MINT-7952386 I2D: score=1 STRING: ENSP00000344456
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA10521462
    GO:0007010cytoskeleton organization IMP10521462
    GO:0007256activation of JNKK activity IMP10521462
    GO:0016055Wnt signaling pathway IEA--
    GO:0031532actin cytoskeleton reorganization IDA15342639

    Find genes that share ontologies with TNIK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNIK

    2 HMDB Compounds for TNIK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNIK gene (8 alternative transcripts): 
    NM_001161560.1  NM_001161561.1  NM_001161562.1  NM_001161563.1  NM_001161564.1  NM_001161565.1  NM_001161566.1  NM_015028.2  

    Unigene Cluster for TNIK:

    TRAF2 and NCK interacting kinase
    Hs.34024  [show with all ESTs]
    Unigene Representative Sequence: NM_015028
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436636(uc003fhh.2 uc003fhi.2 uc003fhj.2 uc003fhk.2 uc003fhl.2 uc003fhm.2 uc003fhn.2 uc003fho.2)
    ENST00000496492 ENST00000341852 ENST00000464785 ENST00000284483 ENST00000475336
    ENST00000357327 ENST00000460047 ENST00000488470 ENST00000470834 ENST00000484051(uc003fhp.3)
    ENST00000487846 ENST00000459881 ENST00000468757 ENST00000465393(uc003fhq.3)
    ENST00000369326 ENST00000538048(uc003fhg.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat TNIK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNIK (see all 15):
    hsa-miR-1197 hsa-miR-3166 hsa-miR-575 hsa-miR-1324 hsa-miR-138-2* hsa-miR-218 hsa-miR-942 hsa-miR-567
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TNIK
    Clone
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    OriGene clones in human, mouse for TNIK (see all 50)
    OriGene ORF clones in mouse, rat for TNIK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): TNIK (NM_015028)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNIK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNIK
    Addgene plasmids for TNIK 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TNIK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNIK
      QuantiTect SYBR Green Assays in human, mouse, rat TNIK
      QuantiFast Probe-based Assays in human, mouse, rat TNIK

    Additional mRNA sequence: 

    AB011123.2 AB017115.1 AF172264.1 AF172265.1 AF172266.1 AF172267.1 AF172268.1 AF172269.1 
    AF172270.1 AF172271.1 AK026470.1 AK291056.1 BC018093.1 BC019081.2 BC055427.1 BC150256.1 
    NR_027767.1 

    15 DOTS entries:

    DT.213701  DT.100763572  DT.95235233  DT.70103269  DT.101962991  DT.91745567  DT.100763573  DT.95167600 
    DT.120850762  DT.95167601  DT.100763570  DT.120850786  DT.65286314  DT.91745564  DT.40292664 

    Selected AceView cDNA sequences (see all 124):

    AI336866 AW294097 AA344347 AI364494 AA928095 AI279800 BU160689 AB011123 
    AA228116 BU183894 BQ022917 BF431017 BM689736 AF172266 AF172267 BE671784 
    BC055427 BE220985 AF172264 AF172265 BQ003657 BM474419 BQ006656 BE672974 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TNIK (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^
    SP1:                    -                                                                                                                 -                     
    SP2:                    -                                                                                   -                             -                     
    SP3:                    -                                                                       -                                         -                     
    SP4:                    -                                                                       -           -                             -                     
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b
    SP1:              -                                   -                     
    SP2:              -                                   -                     
    SP3:              -                                   -                     
    SP4:              -                                   -                     
    SP5:              -                                   -                     


    ECgene alternative splicing isoforms for TNIK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNIK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TNIK Expression
    About this image


    TNIK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    TNIK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNIK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.34024

    UniProtKB/Swiss-Prot: TNIK_HUMAN, Q9UKE5
    Tissue specificity: Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed
    in normal colonic epithelia and colorectal cancer tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TNIK gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnik1 , 5 TRAF2 and NCK interacting kinase1, 5 91.05(n)1
    98.82(a)1
      3 (11.92 cM)5
    6651131  NM_026910.11  NP_081186.11 
     282632145 
    chicken
    (Gallus gallus)
    Aves TNIK1 TRAF2 and NCK interacting kinase 83.73(n)
    95.67(a)
      424987  XM_422794.4  XP_422794.3 
    lizard
    (Anolis carolinensis)
    Reptilia TNIK6
    TRAF2 and NCK interacting kinase
    93(a)
    1 ↔ 1
    3(7022662-7308934)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.314122 Xenopus laevis transcribed sequence with moderate similarity more 81.4(n)    BU914787.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc52d112 wufc52d11 76.35(n)   325042  BC055134.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta msn6
    misshapen
    42(a)
    1 → many
    3L(2554847-2586540)
    worm
    (Caenorhabditis elegans)
    Secernentea mig-156
    Protein MIG-15, isoform a (mig-15) mRNA, complete ...
    51(a)
    1 → many
    X(10421655-10428650) WBGene00003247


    ENSEMBL Gene Tree for TNIK (if available)
    TreeFam Gene Tree for TNIK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNIK gene
    TAOK22  MAP4K52  TAOK32  NRK2  MAP4K22  MAP4K12  MAP4K32  MAP4K42  
    STK102  TAOK12  MINK12  SLK2  
    Selected SIMAP similar genes for TNIK using alignment to 6 protein entries:     TNIK_HUMAN (see all proteins) (see all similar genes):
    AD 2    MINK1    MAP4K5    MAP4K4    MYO3A    STK25
    MAP4K3    TAOK3    STK4/SLC36AL fusion    STK24    MAP4K2    STK3
    MYO3B    PAK4    TXK    DKFZp686J1430    PAK1    MST4

    Find genes that share paralogs with TNIK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNIK (see all 8061)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124892531,2
    C,F,H--170780029(+) CATTGG/AATTCC 8 -- int110Minor allele frequency- A:0.08EA NS NA WA CSA 547
    rs124892771,2
    C,F,H--170780083(+) GTTTCG/ATTTTA 8 -- int16Minor allele frequency- A:0.10NA WA 246
    rs124892791,2
    C,F,A,H--170780116(+) TTGCCG/AGTTGA 8 -- int112Minor allele frequency- A:0.09NA EA NS WA 686
    rs1482070981,2
    --170780272(+) GGAAAA/GAAAAA 8 -- int10--------
    rs1427220401,2
    C--170780386(+) GTATGG/TTGGGT 8 -- ut310--------
    rs1868465831,2
    --170780444(+) GCCTTC/GCTTTC 8 -- ut310--------
    rs1473494071,2
    --170780470(+) GGAGCA/CAATGA 8 -- ut310--------
    rs1900276981,2
    --170780472(+) AGCCAA/GTGATG 8 -- ut310--------
    rs1822094711,2
    --170780595(+) CTTGAA/GAAAGT 8 -- ut310--------
    rs1871746951,2
    --170780861(+) TCCCTC/GCATCG 8 -- ut310--------

    HapMap Linkage Disequilibrium report for TNIK (170779128 - 171029128 bp, first 250kb of TNIK)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TNIK (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726197CNV Deletion23290073
    esv2726198CNV Deletion23290073
    esv1491587CNV Deletion17803354
    esv2678853CNV Deletion23128226
    esv2726199CNV Deletion23290073
    esv1002266CNV Deletion20482838
    esv2726200CNV Deletion23290073
    nsv4115CNV Insertion18451855
    nsv460988CNV Loss19166990
    nsv822341CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TNIK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610005    OMIM disorders: --


    Find genes that share disorders with TNIK           About GenesLikeMe

    Genetic Association Database (GAD): TNIK
    Human Genome Epidemiology (HuGE) Navigator: TNIK (3 documents)

    Export disorders for TNIK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNIK gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with TNIK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton. (PubMed id 10521462)1, 2, 3, 9 Fu C.A.... Luo Y. (J. Biol. Chem. 1999)
    2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (DNA Res. 1998)
    3. Rap2 function requires palmitoylation and recycling endosome localization. (PubMed id 19061864)1, 2, 9 Uechi Y.... Kariya K. (Biochem. Biophys. Res. Commun. 2009)
    4. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PubMed id 21347282)1, 4 Lettre G....Boerwinkle E. (PLoS Genet. 2011)
    5. Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. (PubMed id 20159449)1, 2 Kawabe H.... Brose N. (Neuron 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. (PubMed id 19023125)1, 4 Potkin S.G....Macciardi F. (Schizophr Bull 2009)
    8. The kinase TNIK is an essential activator of Wnt target genes. (PubMed id 19816403)1, 2 Mahmoudi T.... Clevers H. (EMBO J. 2009)
    9. MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. (PubMed id 18930710)1, 2 Nonaka H....Kariya K. (Biochem. Biophys. Res. Commun. 2008)
    10. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23043 HGNC: 30765 AceView: TNIK Ensembl:ENSG00000154310 euGenes: HUgn23043
    ECgene: TNIK H-InvDB: TNIK

    (According to HUGE)
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    HUGE: KIAA0551

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNIK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNIK gene:
    Search GeneIP for patents involving TNIK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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