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Aliases for TNIK Gene

Aliases for TNIK Gene

  • TRAF2 And NCK Interacting Kinase 2 3
  • EC 2.7.11.1 4 64
  • KIAA0551 4 6
  • EC 2.7.11 64

External Ids for TNIK Gene

Summaries for TNIK Gene

Entrez Gene Summary for TNIK Gene

  • Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TNIK Gene

TNIK (TRAF2 And NCK Interacting Kinase) is a Protein Coding gene. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Cellular Senescence. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is MAP4K3.

UniProtKB/Swiss-Prot for TNIK Gene

  • Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.

Gene Wiki entry for TNIK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNIK Gene

Genomics for TNIK Gene

Genomic Location for TNIK Gene

Start:
171,061,339 bp from pter
End:
171,460,408 bp from pter
Size:
399,070 bases
Orientation:
Minus strand

Genomic View for TNIK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNIK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNIK Gene

Regulatory Elements for TNIK Gene

Proteins for TNIK Gene

  • Protein details for TNIK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKE5-TNIK_HUMAN
    Recommended name:
    TRAF2 and NCK-interacting protein kinase
    Protein Accession:
    Q9UKE5
    Secondary Accessions:
    • A7E2A3
    • A8K4U1
    • D3DNQ6
    • O60298
    • Q8WUY7
    • Q9UKD8
    • Q9UKD9
    • Q9UKE0
    • Q9UKE1
    • Q9UKE2
    • Q9UKE3
    • Q9UKE4

    Protein attributes for TNIK Gene

    Size:
    1360 amino acids
    Molecular mass:
    154943 Da
    Quaternary structure:
    • Interacts (via the CNH domain) with RAP2A (GTP-bound form preferentially); the interaction is direct and required for the activation of TNIK by RAP2A. Interacts with NEDD4; recruits RAP2A to NEDD4. Interacts with TRAF2 and NCK. Interacts with TCF7L2/TCF4 and CTNNB1; the interaction is direct. Interacts with TANC1.
    SequenceCaution:
    • Sequence=BAA25477.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNIK Gene

    Alternative splice isoforms for TNIK Gene

neXtProt entry for TNIK Gene

Proteomics data for TNIK Gene at MOPED

Post-translational modifications for TNIK Gene

  • Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys46 and Lys1319

Domains for TNIK Gene

Gene Families for TNIK Gene

UniProtKB/Swiss-Prot:

TNIK_HUMAN
Domain:
  • Contains 1 CNH domain.:
    • Q9UKE5
  • Contains 1 protein kinase domain.:
    • Q9UKE5
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.:
    • Q9UKE5
genes like me logo Genes that share domains with TNIK: view

Function for TNIK Gene

Molecular function for TNIK Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.

Enzyme Numbers (IUBMB) for TNIK Gene

Gene Ontology (GO) - Molecular Function for TNIK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 22797597
GO:0004674 protein serine/threonine kinase activity IDA 10521462
GO:0004702 receptor signaling protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 10521462
genes like me logo Genes that share ontologies with TNIK: view
genes like me logo Genes that share phenotypes with TNIK: view

miRNA for TNIK Gene

miRTarBase miRNAs that target TNIK

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TNIK Gene

Localization for TNIK Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNIK Gene

Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNIK Gene COMPARTMENTS Subcellular localization image for TNIK gene
Compartment Confidence
cytoskeleton 5
endosome 5
nucleus 5
cytosol 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TNIK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19816403
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005768 endosome --
GO:0005856 cytoskeleton IDA 15342639
genes like me logo Genes that share ontologies with TNIK: view

Pathways for TNIK Gene

genes like me logo Genes that share pathways with TNIK: view

Gene Ontology (GO) - Biological Process for TNIK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 22797597
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006468 protein phosphorylation IDA 10521462
GO:0007010 cytoskeleton organization IMP 10521462
GO:0007256 activation of JNKK activity IMP 10521462
genes like me logo Genes that share ontologies with TNIK: view

Compounds for TNIK Gene

(2) HMDB Compounds for TNIK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with TNIK: view

Transcripts for TNIK Gene

Unigene Clusters for TNIK Gene

TRAF2 and NCK interacting kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNIK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:

ExUns: 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7:

Relevant External Links for TNIK Gene

GeneLoc Exon Structure for
TNIK
ECgene alternative splicing isoforms for
TNIK

Expression for TNIK Gene

mRNA expression in normal human tissues for TNIK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNIK Gene

SOURCE GeneReport for Unigene cluster for TNIK Gene Hs.34024

mRNA Expression by UniProt/SwissProt for TNIK Gene

Q9UKE5-TNIK_HUMAN
Tissue specificity: Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
genes like me logo Genes that share expressions with TNIK: view

Orthologs for TNIK Gene

This gene was present in the common ancestor of animals.

Orthologs for TNIK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNIK 36
  • 99.73 (n)
  • 99.93 (a)
TNIK 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNIK 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNIK 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnik 36
  • 91.05 (n)
  • 98.82 (a)
Tnik 16
Tnik 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNIK 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNIK 37
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNIK 36
  • 83.73 (n)
  • 95.67 (a)
TNIK 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNIK 37
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.31412 36
tropical clawed frog
(Silurana tropicalis)
Amphibia tnik 36
  • 79.02 (n)
  • 89.4 (a)
zebrafish
(Danio rerio)
Actinopterygii tnika 36
  • 72.85 (n)
  • 82.23 (a)
tnika 37
  • 82 (a)
OneToMany
tnikb 37
  • 79 (a)
OneToMany
wufc52d11 36
fruit fly
(Drosophila melanogaster)
Insecta msn 37
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-15 37
  • 51 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7227 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3520 37
  • 47 (a)
OneToMany
Species with no ortholog for TNIK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNIK Gene

ENSEMBL:
Gene Tree for TNIK (if available)
TreeFam:
Gene Tree for TNIK (if available)

Paralogs for TNIK Gene

genes like me logo Genes that share paralogs with TNIK: view

Variants for TNIK Gene

Sequence variations from dbSNP and Humsavar for TNIK Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1231 -- 171,313,444(+) GCCCC(A/T)GAAAT intron-variant
rs1794 -- 171,345,614(+) ACCCT(C/T)AAGCC intron-variant
rs2917 -- 171,322,369(+) ATTGT(C/G)AAATA intron-variant
rs721912 -- 171,442,645(+) GTTTC(C/T)AGTGA intron-variant
rs721913 -- 171,442,751(+) CCATG(C/T)TAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNIK Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv877981 CNV Gain 21882294
nsv822341 CNV Loss 20364138
esv8581 CNV Gain 19470904
nsv877982 CNV Loss 21882294
nsv4115 CNV Insertion 18451855
esv2726197 CNV Deletion 23290073
esv2726198 CNV Deletion 23290073
esv1002266 CNV Deletion 20482838
esv2726199 CNV Deletion 23290073
esv1491587 CNV Deletion 17803354
esv2726200 CNV Deletion 23290073
esv2678853 CNV Deletion 23128226
nsv460988 CNV Loss 19166990

Relevant External Links for TNIK Gene

HapMap Linkage Disequilibrium report
TNIK

Disorders for TNIK Gene

Relevant External Links for TNIK

Genetic Association Database (GAD)
TNIK
Human Genome Epidemiology (HuGE) Navigator
TNIK
genes like me logo Genes that share disorders with TNIK: view

No data available for UniProtKB/Swiss-Prot for TNIK Gene

Publications for TNIK Gene

  1. TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton. (PMID: 10521462) Fu C.A. … Luo Y. (J. Biol. Chem. 1999) 2 3 4 23
  2. Rap2 function requires palmitoylation and recycling endosome localization. (PMID: 19061864) Uechi Y. … Kariya K. (Biochem. Biophys. Res. Commun. 2009) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  5. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl G.R. … Lerman C. (Arch. Gen. Psychiatry 2008) 3 49

Products for TNIK Gene

  • Addgene plasmids for TNIK

Sources for TNIK Gene

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