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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNIK Gene

protein-coding   GIFtS: 63
GCID: GC03M170779

TRAF2 And NCK Interacting Kinase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TRAF2 And NCK Interacting Kinase1 2
EC 2.7.11.13 8
KIAA05513 5
TRAF2 And NCK-Interacting Protein Kinase2
EC 2.7.118

External Ids:    HGNC: 307651   Entrez Gene: 230432   Ensembl: ENSG000001543107   OMIM: 6100055   UniProtKB: Q9UKE53   

Export aliases for TNIK gene to outside databases

Previous GC identifers: GC03M172102 GC03M172262 GC03M168150


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNIK Gene:
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal
GCK domain that serves a regulatory function (Fu et al., 1999 (PubMed 10521462)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TNIK Gene: 
TNIK (TRAF2 and NCK interacting kinase) is a protein-coding gene. Diseases associated with TNIK include schizophrenia, and colorectal cancer. GO annotations related to this gene include protein serine/threonine kinase activity and small GTPase regulator activity. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: TNIK_HUMAN, Q9UKE5
Function: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to
promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2.
Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress.
Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and
arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate
cell spreading. Phosphorylates SMAD1 on Thr-322

Gene Wiki entry for TNIK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNIK gene promoter:
         Egr-3   Sox5   Spz1   AP-1   ATF-2   CUTL1   LCR-F1   Egr-4   IRF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNIK promoter sequence
   Search SABiosciences Chromatin IP Primers for TNIK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNIK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.31   Ensembl cytogenetic band:  3q26.31   HGNC cytogenetic band: 3q26.31

TNIK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNIK gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M170779:  view genomic region     (about GC identifiers)

Start:
170,779,128 bp from pter      End:
171,178,197 bp from pter
Size:
399,070 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNIK_HUMAN, Q9UKE5 (See protein sequence)
Recommended Name: TRAF2 and NCK-interacting protein kinase  
Size: 1360 amino acids; 154943 Da
Subunit: Interacts (via the CNH domain) with RAP2A (GTP-bound form preferentially); the interaction is direct and
required for the activation of TNIK by RAP2A. Interacts with NEDD4; recruits RAP2A to NEDD4. Interacts with TRAF2
and NCK. Interacts with TCF7L2/TCF4 and CTNNB1; the interaction is direct. Interacts with TANC1
Subcellular location: Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with
recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression
Sequence caution: Sequence=BAA25477.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for TNIK:
2X7F (3D)    
Secondary accessions: A7E2A3 A8K4U1 D3DNQ6 O60298 Q8WUY7 Q9UKD8 Q9UKD9 Q9UKE0 Q9UKE1 Q9UKE2
Q9UKE3 Q9UKE4
Alternative splicing: 8 isoforms:  Q9UKE5-1   Q9UKE5-2   Q9UKE5-3   Q9UKE5-4   Q9UKE5-5   Q9UKE5-6   Q9UKE5-7   Q9UKE5-8   

Explore the universe of human proteins at neXtProt for TNIK: NX_Q9UKE5

Explore proteomics data for TNIK at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UKE5

  • 4/31 DME Specific Peptides for TNIK (Q9UKE5) (see all 31)
     RNDKVFF  PFIRDQP  WMAPEVI  MEFCGAGS 

    TNIK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNIK Protein Expression
    REFSEQ proteins (8 alternative transcripts): 
    NP_001155032.1  NP_001155033.1  NP_001155034.1  NP_001155035.1  NP_001155036.1  NP_001155037.1  NP_001155038.1  NP_055843.1  

    ENSEMBL proteins: 
     ENSP00000399511   ENSP00000345352   ENSP00000284483   ENSP00000418156   ENSP00000349880  
     ENSP00000418916   ENSP00000418378   ENSP00000419990   ENSP00000417338   ENSP00000419308  
     ENSP00000358332   ENSP00000443278  

    Human Recombinant Protein Products for TNIK: 
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    Cloud-Clone Corp. Proteins for TNIK 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton IDA15342639
    GO:0055037recycling endosome IEA--

    TNIK for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for TNIK 

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    Cloud-Clone Corp. CLIAs for TNIK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: TRAF2 and NCK interacting kinase 
    MSN subfamily

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR001180 Citron
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q9UKE5

    ProtoNet protein and cluster: Q9UKE5

    1 Blocks protein domain: IPB001180 Citron-like

    UniProtKB/Swiss-Prot: TNIK_HUMAN, Q9UKE5
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CNH domain
    Similarity: Contains 1 protein kinase domain


    TNIK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNIK_HUMAN, Q9UKE5
    Function: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to
    promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2.
    Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress.
    Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and
    arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate
    cell spreading. Phosphorylates SMAD1 on Thr-322
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA10521462
    GO:0004713protein tyrosine kinase activity ----
    GO:0005083small GTPase regulator activity IEA--
    GO:0005515protein binding IPI10521462
         
    TNIK for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for TNIK:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased telomerase activity  Gemcitabine induced cell-death 
     Increased colony dispersion (i  Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tnik):
     adipose tissue  behavior/neurological  cellular  growth/size  homeostasis/metabolism 
     nervous system  skeleton 

    TNIK for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNIK 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNIK 
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    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNIK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNIK About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    2TNF receptor signaling pathway
    TNF receptor signaling pathway


    2 BioSystems Pathways for TNIK
        TNF receptor signaling pathway
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNIK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/142 Interacting proteins for TNIK (Q9UKE51, 2, 3 ENSP000003995114) via UniProtKB, MINT, STRING, and/or I2D (see all 142)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNB1P352222, 3, ENSP000003444564MINT-7952397 MINT-7952417 MINT-7952375 MINT-7952386 I2D: score=1 STRING: ENSP00000344456
    TCF7L2Q9NQB02, 3, ENSP000003584044MINT-7952375 MINT-7952429 MINT-7952386 I2D: score=1 STRING: ENSP00000358404
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA10521462
    GO:0006950response to stress ----
    GO:0007010cytoskeleton organization IMP10521462
    GO:0007243intracellular protein kinase cascade IDA10521462
    GO:0007256activation of JNKK activity IMP10521462

    TNIK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNIK

    2 HMDB Compounds for TNIK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about TNIK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNIK gene (8 alternative transcripts): 
    NM_001161560.1  NM_001161561.1  NM_001161562.1  NM_001161563.1  NM_001161564.1  NM_001161565.1  NM_001161566.1  NM_015028.2  

    Unigene Cluster for TNIK:

    TRAF2 and NCK interacting kinase
    Hs.34024  [show with all ESTs]
    Unigene Representative Sequence: NM_015028
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436636(uc003fhh.2 uc003fhi.2 uc003fhj.2 uc003fhk.2 uc003fhl.2 uc003fhm.2 uc003fhn.2 uc003fho.2)
    ENST00000496492 ENST00000341852 ENST00000464785 ENST00000284483 ENST00000475336
    ENST00000357327 ENST00000460047 ENST00000488470 ENST00000470834 ENST00000484051(uc003fhp.3)
    ENST00000487846 ENST00000459881 ENST00000468757 ENST00000465393(uc003fhq.3)
    ENST00000369326 ENST00000538048(uc003fhg.2)
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate TNIK (see all 15):
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    Additional mRNA sequence: 

    AB011123.2 AB017115.1 AF172264.1 AF172265.1 AF172266.1 AF172267.1 AF172268.1 AF172269.1 
    AF172270.1 AF172271.1 AK026470.1 AK291056.1 BC018093.1 BC019081.2 BC055427.1 BC150256.1 
    NR_027767.1 

    15 DOTS entries:

    DT.213701  DT.100763572  DT.95235233  DT.70103269  DT.101962991  DT.91745567  DT.100763573  DT.95167600 
    DT.120850762  DT.95167601  DT.100763570  DT.120850786  DT.65286314  DT.91745564  DT.40292664 

    24/124 AceView cDNA sequences (see all 124):

    AI336866 AF172270 BM474419 AW294097 BQ006656 AA928095 AF172267 BU160689 
    BE671784 BF431017 AA344347 BE672974 BQ022917 AF172266 AF172271 BM689736 
    BC055427 AI348328 BU183894 BM837965 BQ003657 AI699089 AF172268 BM759496 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TNIK (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^
    SP1:                    -                                                                                                                 -                     
    SP2:                    -                                                                                   -                             -                     
    SP3:                    -                                                                       -                                         -                     
    SP4:                    -                                                                       -           -                             -                     
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b
    SP1:              -                                   -                     
    SP2:              -                                   -                     
    SP3:              -                                   -                     
    SP4:              -                                   -                     
    SP5:              -                                   -                     


    ECgene alternative splicing isoforms for TNIK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNIK expression in normal human tissues (normalized intensities)      TNIK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TNIK Expression
    About this image


    TNIK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
             cd8+ t cell   
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac

    See TNIK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNIK

    SOURCE GeneReport for Unigene cluster: Hs.34024

    UniProtKB/Swiss-Prot: TNIK_HUMAN, Q9UKE5
    Tissue specificity: Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed
    in normal colonic epithelia and colorectal cancer tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TNIK gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnik1 , 5 TRAF2 and NCK interacting kinase1, 5 91.05(n)1
    98.82(a)1
      3 (11.92 cM)5
    6651131  NM_026910.11  NP_081186.11 
     282632145 
    chicken
    (Gallus gallus)
    Aves TNIK1 TRAF2 and NCK interacting kinase 83.83(n)
    95.97(a)
      424987  XM_422794.3  XP_422794.2 
    lizard
    (Anolis carolinensis)
    Reptilia TNIK6
    TRAF2 and NCK interacting kinase
    93(a)
    1 ↔ 1
    3(7022662-7308934)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.314122 Xenopus laevis transcribed sequence with moderate similarity more 81.4(n)    BU914787.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc52d112 wufc52d11 76.35(n)   325042  BC055134.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta msn6
    misshapen
    41(a)
    1 → many
    3L(2554847-2586540)
    worm
    (Caenorhabditis elegans)
    Secernentea mig-156
    Serine/threonine-protein kinase mig-15
    49(a)
    1 → many
    X(10421655-10428650)


    ENSEMBL Gene Tree for TNIK (if available)
    TreeFam Gene Tree for TNIK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNIK gene
    TAOK22  MAP4K52  TAOK32  NRK2  MAP4K22  MAP4K12  MAP4K32  MAP4K42  
    STK102  TAOK12  MINK12  SLK2  
    18/55 SIMAP similar genes for TNIK using alignment to 6 protein entries:     TNIK_HUMAN (see all proteins) (see all similar genes):
    AD 2    MINK1    MAP4K5    MAP4K4    MYO3A    STK25
    MAP4K3    TAOK3    STK4/SLC36AL fusion    STK24    MAP4K2    STK3
    MYO3B    PAK4    TXK    DKFZp686J1430    PAK1    MST4

    TNIK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8061 SNPs in TNIK are shown (see all 8061)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0412314
    ----see VAR_0412312 K E mis40--------
    rs124892531,2
    C,F,H--170780029(+) CATTGG/AATTCC 8 -- int110Minor allele frequency- A:0.08EA NS NA WA CSA 547
    rs124892771,2
    C,F,H--170780083(+) GTTTCG/ATTTTA 8 -- int16Minor allele frequency- A:0.10NA WA 246
    rs124892791,2
    C,F,A,H--170780116(+) TTGCCG/AGTTGA 8 -- int112Minor allele frequency- A:0.09NA EA NS WA 686
    rs1482070981,2
    --170780272(+) GGAAAA/GAAAAA 8 -- int10--------
    rs1427220401,2
    C--170780386(+) GTATGG/TTGGGT 8 -- ut310--------
    rs1868465831,2
    --170780444(+) GCCTTC/GCTTTC 8 -- ut310--------
    rs1473494071,2
    --170780470(+) GGAGCA/CAATGA 8 -- ut310--------
    rs1900276981,2
    --170780472(+) AGCCAA/GTGATG 8 -- ut310--------
    rs1822094711,2
    --170780595(+) CTTGAA/GAAAGT 8 -- ut310--------

    HapMap Linkage Disequilibrium report for TNIK (170779128 - 171029128 bp, first 250kb of TNIK)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for TNIK (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726197CNV Deletion23290073
    esv2726198CNV Deletion23290073
    esv1491587CNV Deletion17803354
    esv2678853CNV Deletion23128226
    esv2726199CNV Deletion23290073
    esv1002266CNV Deletion20482838
    esv2726200CNV Deletion23290073
    nsv4115CNV Insertion18451855
    nsv460988CNV Loss19166990
    nsv822341CNV Loss20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610005    OMIM disorders: --

    3 diseases for TNIK:    About MalaCards
    schizophrenia    colorectal cancer    neuronitis


    TNIK for disorders           About GeneDecksing

    Genetic Association Database (GAD): TNIK
    Human Genome Epidemiology (HuGE) Navigator: TNIK (3 documents)

    Export disorders for TNIK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNIK gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with TNIK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton. (PubMed id 10521462)1, 2, 3, 9 Fu C.A....Luo Y. (1999)
    2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (1998)
    3. Rap2 function requires palmitoylation and recycling endosome localization. (PubMed id 19061864)1, 2, 9 Uechi Y....Kariya K. (2009)
    4. Genome-wide association study of coronary heart disea se and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PubMed id 21347282)1, 4 Lettre G....Boerwinkle E. (2011)
    5. Regulation of Rap2A by the ubiquitin ligase Nedd4-1 c ontrols neurite development. (PubMed id 20159449)1, 2 Kawabe H....Brose N. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. (PubMed id 19023125)1, 4 Potkin S.G....Macciardi F. (2009)
    8. The kinase TNIK is an essential activator of Wnt target genes. (PubMed id 19816403)1, 2 Mahmoudi T.... Clevers H. (2009)
    9. MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. (PubMed id 18930710)1, 2 Nonaka H....Kariya K. (2008)
    10. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23043 HGNC: 30765 AceView: TNIK Ensembl:ENSG00000154310 euGenes: HUgn23043
    ECgene: TNIK H-InvDB: TNIK

    (According to HUGE)
    About This Section
    HUGE: KIAA0551

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNIK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNIK gene:
    Search GeneIP for patents involving TNIK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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