Aliases for TNIK Gene
External Ids for TNIK Gene
Previous GeneCards Identifiers for TNIK Gene
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]
GeneCards Summary for TNIK Gene
TNIK (TRAF2 And NCK Interacting Kinase) is a Protein Coding gene. Diseases associated with TNIK include Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are Cellular Senescence and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K4.
UniProtKB/Swiss-Prot for TNIK Gene
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.