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Aliases for TNIK Gene

Aliases for TNIK Gene

  • TRAF2 And NCK Interacting Kinase 2 3 5
  • EC 2.7.11.1 4 63
  • EC 2.7.11 63
  • KIAA0551 4

External Ids for TNIK Gene

Previous GeneCards Identifiers for TNIK Gene

  • GC03M172102
  • GC03M172262
  • GC03M170779
  • GC03M168150

Summaries for TNIK Gene

Entrez Gene Summary for TNIK Gene

  • Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TNIK Gene

TNIK (TRAF2 And NCK Interacting Kinase) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K3.

UniProtKB/Swiss-Prot for TNIK Gene

  • Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.

Gene Wiki entry for TNIK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNIK Gene

Genomics for TNIK Gene

Regulatory Elements for TNIK Gene

Enhancers for TNIK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TNIK on UCSC Golden Path with GeneCards custom track

Promoters for TNIK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNIK on UCSC Golden Path with GeneCards custom track

Genomic Location for TNIK Gene

Chromosome:
3
Start:
171,061,339 bp from pter
End:
171,460,408 bp from pter
Size:
399,070 bases
Orientation:
Minus strand

Genomic View for TNIK Gene

Genes around TNIK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNIK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNIK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNIK Gene

Proteins for TNIK Gene

  • Protein details for TNIK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKE5-TNIK_HUMAN
    Recommended name:
    TRAF2 and NCK-interacting protein kinase
    Protein Accession:
    Q9UKE5
    Secondary Accessions:
    • A7E2A3
    • A8K4U1
    • D3DNQ6
    • O60298
    • Q8WUY7
    • Q9UKD8
    • Q9UKD9
    • Q9UKE0
    • Q9UKE1
    • Q9UKE2
    • Q9UKE3
    • Q9UKE4

    Protein attributes for TNIK Gene

    Size:
    1360 amino acids
    Molecular mass:
    154943 Da
    Quaternary structure:
    • Interacts (via the CNH domain) with RAP2A (GTP-bound form preferentially); the interaction is direct and required for the activation of TNIK by RAP2A. Interacts with NEDD4; recruits RAP2A to NEDD4. Interacts with TRAF2 and NCK. Interacts with TCF7L2/TCF4 and CTNNB1; the interaction is direct. Interacts with TANC1.
    SequenceCaution:
    • Sequence=BAA25477.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNIK Gene

    Alternative splice isoforms for TNIK Gene

neXtProt entry for TNIK Gene

Proteomics data for TNIK Gene at MOPED

Post-translational modifications for TNIK Gene

  • Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for TNIK Gene

Gene Families for TNIK Gene

Suggested Antigen Peptide Sequences for TNIK Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKE5

UniProtKB/Swiss-Prot:

TNIK_HUMAN :
  • Contains 1 CNH domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • Contains 1 CNH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with TNIK: view

Function for TNIK Gene

Molecular function for TNIK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.

Enzyme Numbers (IUBMB) for TNIK Gene

genes like me logo Genes that share phenotypes with TNIK: view

Animal Models for TNIK Gene

MGI Knock Outs for TNIK:

miRNA for TNIK Gene

miRTarBase miRNAs that target TNIK

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNIK Gene

Localization for TNIK Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNIK Gene

Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNIK Gene COMPARTMENTS Subcellular localization image for TNIK gene
Compartment Confidence
cytoskeleton 5
endosome 5
extracellular 5
nucleus 5
plasma membrane 5
cytosol 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for TNIK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with TNIK: view

Pathways & Interactions for TNIK Gene

genes like me logo Genes that share pathways with TNIK: view

SIGNOR curated interactions for TNIK Gene

Activates:

Gene Ontology (GO) - Biological Process for TNIK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 10521462
GO:0007010 cytoskeleton organization IMP 10521462
GO:0007256 activation of JNKK activity IMP 10521462
GO:0007346 regulation of mitotic cell cycle IBA --
GO:0030033 microvillus assembly IMP 22797597
genes like me logo Genes that share ontologies with TNIK: view

Drugs & Compounds for TNIK Gene

(1) Drugs for TNIK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for TNIK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TNIK: view

Transcripts for TNIK Gene

Unigene Clusters for TNIK Gene

TRAF2 and NCK interacting kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNIK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:

ExUns: 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7:

Relevant External Links for TNIK Gene

GeneLoc Exon Structure for
TNIK
ECgene alternative splicing isoforms for
TNIK

Expression for TNIK Gene

mRNA expression in normal human tissues for TNIK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNIK Gene

This gene is overexpressed in Lung (20.9), Platelet (8.4), and Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNIK Gene



SOURCE GeneReport for Unigene cluster for TNIK Gene Hs.34024

mRNA Expression by UniProt/SwissProt for TNIK Gene

Q9UKE5-TNIK_HUMAN
Tissue specificity: Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
genes like me logo Genes that share expression patterns with TNIK: view

Protein tissue co-expression partners for TNIK Gene

Primer Products

No data available for mRNA differential expression in normal tissues for TNIK Gene

Orthologs for TNIK Gene

This gene was present in the common ancestor of animals.

Orthologs for TNIK Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Tnik 35
  • 91.05 (n)
  • 98.82 (a)
Tnik 16
Tnik 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNIK 35
  • 99.73 (n)
  • 99.93 (a)
TNIK 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNIK 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNIK 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNIK 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNIK 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNIK 35
  • 83.73 (n)
  • 95.67 (a)
TNIK 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNIK 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnik 35
  • 79.02 (n)
  • 89.4 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.31412 35
zebrafish
(Danio rerio)
Actinopterygii tnika 35
  • 72.85 (n)
  • 82.23 (a)
wufc52d11 35
tnika 36
  • 82 (a)
OneToMany
tnikb 36
  • 79 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta msn 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-15 36
  • 51 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7227 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3520 36
  • 47 (a)
OneToMany
Species with no ortholog for TNIK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNIK Gene

ENSEMBL:
Gene Tree for TNIK (if available)
TreeFam:
Gene Tree for TNIK (if available)

Paralogs for TNIK Gene

Paralogs for TNIK Gene

genes like me logo Genes that share paralogs with TNIK: view

Variants for TNIK Gene

Sequence variations from dbSNP and Humsavar for TNIK Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_041231 -
rs35090763 - 171,087,499(+) TCTCT(C/T)CAGAC reference, missense
rs17857452 - 171,085,121(+) ACCTG(C/G/T)GGCTG reference, missense
rs1231 -- 171,313,444(+) GCCCC(A/T)GAAAT intron-variant
rs1794 -- 171,345,614(+) ACCCT(C/T)AAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNIK Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv877981 CNV Gain 21882294
nsv822341 CNV Loss 20364138
esv8581 CNV Gain 19470904
nsv877982 CNV Loss 21882294
nsv4115 CNV Insertion 18451855
esv2726197 CNV Deletion 23290073
esv2726198 CNV Deletion 23290073
esv1002266 CNV Deletion 20482838
esv2726199 CNV Deletion 23290073
esv1491587 CNV Deletion 17803354
esv2726200 CNV Deletion 23290073
esv2678853 CNV Deletion 23128226
nsv460988 CNV Loss 19166990

Variation tolerance for TNIK Gene

Residual Variation Intolerance Score: 2.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TNIK Gene

Disorders for TNIK Gene

Relevant External Links for TNIK

Genetic Association Database (GAD)
TNIK
Human Genome Epidemiology (HuGE) Navigator
TNIK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNIK

No disorders were found for TNIK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNIK Gene

Publications for TNIK Gene

  1. TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton. (PMID: 10521462) Fu C.A. … Luo Y. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Rap2 function requires palmitoylation and recycling endosome localization. (PMID: 19061864) Uechi Y. … Kariya K. (Biochem. Biophys. Res. Commun. 2009) 3 23
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for TNIK Gene

Sources for TNIK Gene

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