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Aliases for TNFSF9 Gene

Aliases for TNFSF9 Gene

  • Tumor Necrosis Factor Superfamily Member 9 2 3 5
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 9 2 3
  • Homolog Of Mouse 4-1BB-L 2 3
  • Receptor 4-1BB Ligand 2 3
  • 4-1BB Ligand 3 4
  • 4-1BBL 3 4
  • Tumor Necrosis Factor Ligand Superfamily Member 9 3
  • Tumor Necrosis Factor Ligand 5A 3
  • 4-1BB-L 3
  • CD137L 3
  • TNLG5A 3

External Ids for TNFSF9 Gene

Previous GeneCards Identifiers for TNFSF9 Gene

  • GC19P006625
  • GC19P006471
  • GC19P006482
  • GC19P006293

Summaries for TNFSF9 Gene

Entrez Gene Summary for TNFSF9 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]

GeneCards Summary for TNFSF9 Gene

TNFSF9 (Tumor Necrosis Factor Superfamily Member 9) is a Protein Coding gene. Among its related pathways are TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions and Immune System. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding.

UniProtKB/Swiss-Prot for TNFSF9 Gene

  • Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF9 Gene

Genomics for TNFSF9 Gene

Regulatory Elements for TNFSF9 Gene

Enhancers for TNFSF9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F006575 1.6 FANTOM5 Ensembl ENCODE 8.3 +49.9 49885 5.5 HDGF PKNOX1 ARNT WRNIP1 GATA2 ZNF207 FOS JUNB TBX21 SMARCA4 TNFSF14 TNFSF9 CD70 DENND1C ZNF557 GC19P006580 ENSG00000199223 GC19M006573
GH19F006582 1.6 FANTOM5 Ensembl ENCODE 4.7 +58.7 58735 9.3 HDGF PKNOX1 ARNT WRNIP1 SIN3A YBX1 ZNF48 ZNF121 GLIS2 ZNF143 LOC390877 FLJ25758 MBD3L5 MBD3L3 ACSBG2 ALKBH7 ENSG00000267571 PRR22 CD70 RPL36
GH19F006515 1.7 FANTOM5 Ensembl ENCODE 3.6 -10.8 -10758 4.4 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YBX1 ZNF2 YY1 ENSG00000267571 ZNF557 SNRPEP4 VMAC LOC390877 FLJ25758 MBD3L3 MBD3L5 MIR6791 ACSBG2
GH19F006592 1.4 FANTOM5 Ensembl ENCODE 4.1 +64.0 63988 0.9 HDGF IRF3 RELA ZNF335 CTBP1 POLR2A EED ZNF143 ETV6 CREM CD70 TNFSF9 DENND1C ZNF557 RPL7P50 GC19P006581
GH19F006674 1.7 FANTOM5 Ensembl ENCODE 1.8 +146.3 146339 1.8 HDGF PKNOX1 CREB3L1 YBX1 ELK1 ZNF143 ZNF207 ZNF548 FOS KDM4B TNFSF14 C3 MIR6791 TRIP10 GPR108 XAB2 ZNF557 ADGRE1 VAV1 TNFSF9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFSF9 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNFSF9 Gene

6,528,562 bp from pter
6,535,928 bp from pter
7,367 bases
Plus strand

Genomic View for TNFSF9 Gene

Genes around TNFSF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF9 Gene

Proteins for TNFSF9 Gene

  • Protein details for TNFSF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor ligand superfamily member 9
    Protein Accession:
    Secondary Accessions:
    • Q2M3S2

    Protein attributes for TNFSF9 Gene

    254 amino acids
    Molecular mass:
    26625 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for TNFSF9 Gene

neXtProt entry for TNFSF9 Gene

Post-translational modifications for TNFSF9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNFSF9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFSF9 (4-1BB Ligand/TNFSF9)
  • Cloud-Clone Corp. Antibodies for TNFSF9

Protein Products

  • Enzo Life Sciences proteins for TNFSF9

No data available for DME Specific Peptides for TNFSF9 Gene

Domains & Families for TNFSF9 Gene

Gene Families for TNFSF9 Gene

Protein Domains for TNFSF9 Gene

Suggested Antigen Peptide Sequences for TNFSF9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tumor necrosis factor family.
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF9: view

Function for TNFSF9 Gene

Molecular function for TNFSF9 Gene

GENATLAS Biochemistry:
,tumor necrosis factor (ligand) superfamily,member 9,inducible T cell antigen 4-1BB ligand
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.

Gene Ontology (GO) - Molecular Function for TNFSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8088337
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0032813 tumor necrosis factor receptor superfamily binding IBA --
genes like me logo Genes that share ontologies with TNFSF9: view
genes like me logo Genes that share phenotypes with TNFSF9: view

Animal Model Products

miRNA for TNFSF9 Gene

miRTarBase miRNAs that target TNFSF9

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFSF9 Gene

Localization for TNFSF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF9 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF9 gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TNFSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFSF9: view

Pathways & Interactions for TNFSF9 Gene

genes like me logo Genes that share pathways with TNFSF9: view

Gene Ontology (GO) - Biological Process for TNFSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 8088337
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 8088337
GO:0007267 cell-cell signaling TAS 8088337
GO:0008283 cell proliferation TAS 8088337
genes like me logo Genes that share ontologies with TNFSF9: view

No data available for SIGNOR curated interactions for TNFSF9 Gene

Transcripts for TNFSF9 Gene

mRNA/cDNA for TNFSF9 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFSF9 Gene

Tumor necrosis factor (ligand) superfamily, member 9:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF9 Gene

No ASD Table

Relevant External Links for TNFSF9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFSF9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFSF9 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFSF9 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFSF9 Gene:


SOURCE GeneReport for Unigene cluster for TNFSF9 Gene:


mRNA Expression by UniProt/SwissProt for TNFSF9 Gene:

Tissue specificity: Expressed in brain, placenta, lung, skeletal muscle and kidney.
genes like me logo Genes that share expression patterns with TNFSF9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for TNFSF9 Gene

Orthologs for TNFSF9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TNFSF9 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TNFSF9 34 35
  • 69.92 (n)
(Bos Taurus)
Mammalia TNFSF9 34 35
  • 63.62 (n)
(Ornithorhynchus anatinus)
Mammalia TNFSF9 35
  • 35 (a)
(Monodelphis domestica)
Mammalia TNFSF9 35
  • 34 (a)
(Mus musculus)
Mammalia Tnfsf9 35
  • 27 (a)
Species where no ortholog for TNFSF9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF9 Gene

Gene Tree for TNFSF9 (if available)
Gene Tree for TNFSF9 (if available)

Paralogs for TNFSF9 Gene

No data available for Paralogs for TNFSF9 Gene

Variants for TNFSF9 Gene

Sequence variations from dbSNP and Humsavar for TNFSF9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10419225 -- 6,535,755(+) gacct(C/G)ccgag utr-variant-3-prime
rs1042455 -- 6,535,662(+) TTTTC(C/T)TTCTT utr-variant-3-prime
rs10426436 -- 6,536,289(+) gttgg(A/G)cacgt downstream-variant-500B
rs10712707 -- 6,535,373(+) GGGGG(-/G)TCTTC utr-variant-3-prime
rs111067248 -- 6,529,588(+) ATGGA(C/G)AGAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TNFSF9 Gene

Variant ID Type Subtype PubMed ID
nsv833728 CNV loss 17160897
nsv833727 CNV loss 17160897
nsv138022 CNV insertion 16902084
nsv1072314 CNV deletion 25765185
esv2668569 CNV deletion 23128226
esv22875 CNV loss 19812545
dgv1700n106 CNV deletion 24896259

Variation tolerance for TNFSF9 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFSF9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF9 Gene

Disorders for TNFSF9 Gene

Relevant External Links for TNFSF9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TNFSF9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFSF9 Gene

Publications for TNFSF9 Gene

  1. The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily. (PMID: 20032458) Won E.Y. … Cho H.S. (J. Biol. Chem. 2010) 3 4 22 64
  2. Molecular and biological characterization of human 4-1BB and its ligand. (PMID: 8088337) Alderson M.R. … Goodwin R.G. (Eur. J. Immunol. 1994) 2 3 4 64
  3. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 64
  5. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee K.M. … Lan Q. (Am. J. Hematol. 2010) 3 46 64

Products for TNFSF9 Gene

Sources for TNFSF9 Gene

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