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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFSF9 Gene

protein-coding   GIFtS: 60
GCID: GC19P006531

tumor necrosis factor (ligand) superfamily, member 9
 Explore 33 diseases affiliated with
TNFSF9 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TNFSF9    

Aliases
for TNFSF9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Necrosis Factor (Ligand) Superfamily, Member 91 2     CD137L2
4-1BB-L1 2     Homolog Of Mouse 4-1BB-L2
4-1BBL2 3     Receptor 4-1BB Ligand2
4-1BB Ligand2 3     Tumor Necrosis Factor Ligand Superfamily Member 92

External Ids:    HGNC: 119391   Entrez Gene: 87442   Ensembl: ENSG000001256577   OMIM: 6061825   UniProtKB: P412733   

Export aliases for TNFSF9 gene to outside databases

Previous GC identifers: GC19P006625 GC19P006471 GC19P006482 GC19P006293


Summaries
for TNFSF9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TNFSF9:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This
transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a
costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen
presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T
lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been
shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also
been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell
lines, and is thought to be involved in T cell-tumor cell interaction.(provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: TNFL9_HUMAN, P41273
Function: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a
role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and
B-cells/macrophages




Genomic Views
for TNFSF9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFSF9 gene promoter:
         TBP   Sp1   TFIID   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNFSF9 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFSF9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFSF9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TNFSF9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFSF9 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P006531:  view genomic region     (about GC identifiers)

Start:
 6,531,010 bp from pter      End:
 6,535,939 bp from pter
Size:
 4,930 bases      Orientation:
 plus strand

Proteins
for TNFSF9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TNFL9_HUMAN, P41273 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 9  
Size: 254 amino acids; 26625 Da
Subunit: Homotrimer
Subcellular location: Membrane; Single-pass type II membrane protein
1 PDB 3D structure from and Proteopedia for TNFSF9:
2X29 (3D)    
Secondary accessions: Q2M3S2

Explore the universe of human proteins at neXtProt for TNFSF9: NX_P41273

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P41273

    • TNFSF9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003802.1  
    ENSEMBL proteins: 
     ENSP00000245817  

    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for TNFSF9 (4-1BB Ligand/TNFSF9)
    Enzo Life Sciences proteins for TNFSF9
    OriGene Purified Protein: TNFSF9
    OriGene Protein Over-expression Lysate: TNFSF9
    OriGene Custom Protein Services for TNFSF9 
    GenScript Custom Purified and Recombinant Proteins Services for TNFSF9
    Novus Biologicals TNFSF9 Proteins
    Novus Biologicals TNFSF9 Lysate
    Sino Biological Recombinant Protein for TNFSF9
    ProSpec Recombinant Protein for TNFSF9
    Uscn Proteins for TNFSF9

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    TNFSF9 for ontologies           About GeneDecksing



    TNFSF9 Antibody Products: 
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    Uscn ELISAs and CLIAs for TNFSF9

    Protein Domains /
    Families
    for TNFSF9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TNFSF9 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006052 TNF
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR021184 TNF_CS

    Graphical View of Domain Structure for InterPro Entry P41273

    ProtoNet protein and cluster: P41273

    1 Blocks protein family: IPB006052 Tumor Necrosis Factor

    UniProtKB/Swiss-Prot: TNFL9_HUMAN, P41273
    Similarity: Belongs to the tumor necrosis factor family


    Function
    for TNFSF9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TNFL9_HUMAN, P41273
    Function: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a
    role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and
    B-cells/macrophages

         Genatlas biochemistry entry for TNFSF9:
    ,tumor necrosis factor (ligand) superfamily,member 9,inducible T cell antigen 4-1BB ligand

    miRNA
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    hsa-mir-16 (MIRT001405)

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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFSF9
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFSF9 (see all 22):
    hsa-let-7d hsa-miR-15a hsa-miR-202 hsa-let-7c hsa-let-7g hsa-miR-424 hsa-let-7a hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmid: TNFSF9 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFSF9 (see all 7)
    OriGene shRNA RFP: TNFSF9
    OriGene siRNA: TNFSF9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFSF9

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF9 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: TNFSF9 (NM_003811)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFSF9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF9 

    Cell Line
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    Search LifeMap BioReagents cell lines for TNFSF9

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TNFSF9

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS8088337
    GO:0005125cytokine activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--


    TNFSF9 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for TNFSF9: Tnfsf9tm1Thw Tnfsf9tm1Lpc
         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Tnfsf9):
     immune system 

    TNFSF9 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TNFSF9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/9 pathways (see all 9)
    		PEDF Induced Signaling1.00
    		RAR-Gamma-RXR-Alpha Degradation0.54
    		MIF Mediated Glucocorticoid Regulation0.73
    		STAT3 Pathway0.47
    		MIF Regulation of Innate Immune Cells0.71
    		Endothelin-1 Signaling Pathway0.44
    		IL-6 Pathway0.61
    		Cytokine-cytokine receptor interaction0.26
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    3PAK Pathway
    		PAK Pathway1.00
    		Antioxidant Action of Vitamin-C0.56
    4Akt Signaling
    		Akt Signaling1.00
    		p38 Signaling0.60
    5TRAF Pathway
    		TNF Superfamily Pathway0.42
    		TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.08

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for TNFSF9
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFSF9 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Rho Family GTPases
    MIF Mediated Glucocorticoid Regulation


    1         Kegg Pathway  (Kegg details for TNFSF9):
        Cytokine-cytokine receptor interaction


    TNFSF9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFSF9

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TNFSF9 (P412733 ENSP000002458174) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF9Q070113, ENSP000003667294I2D: score=2 STRING: ENSP00000366729
    TRAF1Q130773, ENSP000003629944I2D: score=3 STRING: ENSP00000362994
    TRAF2Q129333, ENSP000002476684I2D: score=3 STRING: ENSP00000247668
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS8088337
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS8088337
    GO:0007267cell-cell signaling TAS8088337
    GO:0008283cell proliferation TAS8088337


    TNFSF9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TNFSF9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFSF9
    Search CenterWatch for drugs/clinical trials and news about TNFSF9 / TNFL9 

    Transcripts
    for TNFSF9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TNFSF9 gene: 
    NM_003811.3  

    Unigene Cluster for TNFSF9:

    Tumor necrosis factor (ligand) superfamily, member 9
    Hs.1524  [show with all ESTs]
    Unigene Representative Sequence: NM_003811
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000245817(uc002mfh.2)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFSF9
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFSF9 (see all 22):
    hsa-let-7d hsa-miR-15a hsa-miR-202 hsa-let-7c hsa-let-7g hsa-miR-424 hsa-let-7a hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmid: TNFSF9 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFSF9 (see all 7)
    OriGene shRNA RFP: TNFSF9
    OriGene siRNA: TNFSF9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFSF9
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF9 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TNFSF9 (NM_003811)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFSF9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF9 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFSF9
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TNFSF9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFSF9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFSF9

    Additional cDNA sequence: 

    AK313999.1 BC104805.1 BC104807.1 U03398.1 

    1 DOTS entry:

    DT.204520 

    24/32 AceView cDNA sequences (see all 32):

    BM856840 BU631673 BM790119 CA426922 BQ890400 CR624086 BQ722355 AA493857 
    AI357267 BM782490 AI142376 NM_003811 BV198776 BM545061 BX107825 U03398 
    BM744249 CA310489 BX372166 CA307086 AL555486 BU502747 BF001607 AA778663 

    GeneLoc Exon Structure


    Expression
    for TNFSF9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFSF9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCAGTACAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TNFSF9 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TNFSF9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFSF9

    SOURCE GeneReport for Unigene cluster: Hs.1524

    UniProtKB/Swiss-Prot: TNFL9_HUMAN, P41273
    Tissue specificity: Expressed in brain, placenta, lung, skeletal muscle and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFSF9: 
              TNF Ligands & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFSF9
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TNFSF9

    Orthologs
    for TNFSF9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for TNFSF9 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tnfsf95 tumor necrosis factor (ligand) superfamily, member more   --   17 (29.67 cM) 57105385 


    ENSEMBL Gene Tree for TNFSF9 (if available)
    TreeFam Gene Tree for TNFSF9 (if available) 

    Paralogs
    for TNFSF9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TNFSF9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/156 NCBI SNPs in TNFSF9 are shown (see all 156)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs739207001,2
    		C,--6529027(+) GCCCCG/AGATTG 1 -- us2k12Minor allele frequency- A:0.10WA 120
    rs1473773041,2
    		--6529168(+) CCTGCC/TGGGAA 1 -- us2k10--------
    rs1160750871,2
    		F,--6529599(+) ATGGAG/CAGAGA 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1395877211,2
    		--6529614(+) GATAAC/TGGAGC 1 -- us2k10--------
    rs1926542601,2
    		--6529636(+) AGAGTC/GAGAGA 1 -- us2k10--------
    rs1857036861,2
    		--6529670(+) TGACAC/TAGATA 1 -- us2k10--------
    rs1891594221,2
    		--6529729(+) AGAGAC/TAACAG 1 -- us2k10--------
    rs1463743801,2
    		C,--6529739(+) GAGCC-/AGA   
       GACAG    AGAGA     		1 -- us2k10--------
    rs1815560031,2
    		--6529850(+) AGACAA/GAGAGA 1 -- us2k10--------
    rs1177197981,2
    		F,--6529885(+) AAAAGA/CGCCAG 1 -- us2k11Minor allele frequency- C:0.37NA 120

    HapMap Linkage Disequilibrium report for TNFSF9 (6531010 - 6535939 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TNFSF9
         2 CNVs: 73302 5076

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFSF9
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFSF9

    Disorders / Diseases
    for TNFSF9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TNFSF9 for disorders           About GeneDecksing

    OMIM gene information: 606182    OMIM disorders: --

    20/33 diseases for TNFSF9 (see all 33):    About MalaCards
    west nile virus    carcinoma    wegener's granulomatosis    primary biliary cirrhosis
    mouth disease    b-cell lymphomas    mantle cell lymphoma    autoimmune myocarditis
    multiple sclerosis    acute myeloid leukemia    myeloid leukemia    myocarditis
    squamous cell carcinoma    graves' disease    multiple myeloma    laryngitis
    rheumatoid arthritis    laryngeal carcinoma    influenza    hepatitis b

    8 Novoseek disease relationships for TNFSF9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 47.7 21 9045669 (2), 8656679 (1), 16547002 (1), 19233196 (1) (see all 16)
    tumors 43.7 43 10946324 (3), 18026115 (2), 20463597 (2), 9045669 (2) (see all 28)
    solid tumor 21.7 1 19225975 (1)
    multiple sclerosis 4.73 3 16513684 (2), 16970683 (1)
    hiv infections 0 1 16272290 (1)
    influenza 0 1 14745033 (1)
    carcinoma 0 3 10946324 (2), 11564827 (1)
    cancer 0 7 14671675 (1), 14614331 (1), 16285508 (1), 12594573 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: TNFSF9 (10 documents)

    Export disorders for TNFSF9 gene to outside databases

    Publications
    for TNFSF9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFSF9 gene, integrated from 9 sources (see all 125):
    (articles sorted by number of sources associating them with TNFSF9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular and biological characterization of human 4-1BB and its ligand. (PubMed id 8088337)1, 2, 3 Alderson M.R.... Goodwin R.G. (1994)
    2. The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily. (PubMed id 20032458)1, 2, 9 Won E.Y....Cho H.S. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. (PubMed id 8405064)1, 3 Goodwin R.G....Jenkins N.A. (1993)
    5. TNFSF9 expression in primary biliary cirrhosis and it s clinical significance. (PubMed id 20303781)1, 9 Xia R....Zhong R. (2010)
    6. 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function. (PubMed id 11994439)1, 9 Wen T....Watts T.H. (2002)
    7. Production of recombinant human trimeric CD137L (4-1BBL). Cross-linking is essential to its T cell co-stimulation activity. (PubMed id 16204238)1, 9 Rabu C....Lang F. (2005)
    8. Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells. (PubMed id 17977894)1, 9 Habib-Agahi M....Searle P.F. (2007)
    9. Soluble CD137 (4-1BB) ligand is released following leukocyte activation and is found in sera of patients with hematological malignancies. (PubMed id 11564827)1, 9 Salih H.R....Kiener P.A. (2001)
    10. 4-1BBL costimulation retrieves CD28 expression in activated T cells. (PubMed id 19217084)1, 9 Habib-Agahi M....Searle P.F. (2009)

    External Searches for TNFSF9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing TNFSF9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8744 HGNC: 11939 AceView: TNFSF9 Ensembl:ENSG00000125657 euGenes: HUgn8744
    ECgene: TNFSF9 Kegg: 8744 H-InvDB: TNFSF9

    Other Databases showing TNFSF9 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TNFSF9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFSF9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFSF9 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TNFSF9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TNFSF9 gene:
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