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Aliases for TNFSF9 Gene

Aliases for TNFSF9 Gene

  • Tumor Necrosis Factor (Ligand) Superfamily, Member 9 2 3
  • Homolog Of Mouse 4-1BB-L 2 3
  • Receptor 4-1BB Ligand 2 3
  • 4-1BB Ligand 3 4
  • 4-1BBL 3 4
  • Tumor Necrosis Factor Ligand Superfamily Member 9 3
  • 4-1BB-L 3
  • CD137L 3

External Ids for TNFSF9 Gene

Previous GeneCards Identifiers for TNFSF9 Gene

  • GC19P006625
  • GC19P006471
  • GC19P006482
  • GC19P006293

Summaries for TNFSF9 Gene

Entrez Gene Summary for TNFSF9 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]

GeneCards Summary for TNFSF9 Gene

TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9) is a Protein Coding gene. Diseases associated with TNFSF9 include primary biliary cirrhosis. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding.

UniProtKB/Swiss-Prot for TNFSF9 Gene

  • Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF9 Gene

Genomics for TNFSF9 Gene

Regulatory Elements for TNFSF9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNFSF9 Gene

6,528,562 bp from pter
6,535,928 bp from pter
7,367 bases
Plus strand

Genomic View for TNFSF9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFSF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF9 Gene

Proteins for TNFSF9 Gene

  • Protein details for TNFSF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor ligand superfamily member 9
    Protein Accession:
    Secondary Accessions:
    • Q2M3S2

    Protein attributes for TNFSF9 Gene

    254 amino acids
    Molecular mass:
    26625 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for TNFSF9 Gene

neXtProt entry for TNFSF9 Gene

Proteomics data for TNFSF9 Gene at MOPED

Post-translational modifications for TNFSF9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNFSF9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFSF9 (4-1BB Ligand/TNFSF9)

No data available for DME Specific Peptides for TNFSF9 Gene

Domains for TNFSF9 Gene

Gene Families for TNFSF9 Gene

Protein Domains for TNFSF9 Gene

Suggested Antigen Peptide Sequences for TNFSF9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tumor necrosis factor family.
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF9: view

Function for TNFSF9 Gene

Molecular function for TNFSF9 Gene

GENATLAS Biochemistry:
,tumor necrosis factor (ligand) superfamily,member 9,inducible T cell antigen 4-1BB ligand
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.

Gene Ontology (GO) - Molecular Function for TNFSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8088337
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding --
GO:0032813 tumor necrosis factor receptor superfamily binding IBA --
genes like me logo Genes that share ontologies with TNFSF9: view

Phenotypes for TNFSF9 Gene

genes like me logo Genes that share phenotypes with TNFSF9: view

Animal Models for TNFSF9 Gene

MGI Knock Outs for TNFSF9:

Animal Model Products

miRNA for TNFSF9 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFSF9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNFSF9 Gene

Localization for TNFSF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF9 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for TNFSF9 Gene COMPARTMENTS Subcellular localization image for TNFSF9 gene
Compartment Confidence
extracellular 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TNFSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFSF9: view

Pathways for TNFSF9 Gene

genes like me logo Genes that share pathways with TNFSF9: view

Pathways by source for TNFSF9 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • TNF Ligands & Receptors in human,mouse,rat

Gene Ontology (GO) - Biological Process for TNFSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 8088337
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 8088337
GO:0007267 cell-cell signaling TAS 8088337
GO:0008283 cell proliferation TAS 8088337
genes like me logo Genes that share ontologies with TNFSF9: view

Transcripts for TNFSF9 Gene

mRNA/cDNA for TNFSF9 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFSF9 Gene

Tumor necrosis factor (ligand) superfamily, member 9:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFSF9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF9 Gene

No ASD Table

Relevant External Links for TNFSF9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFSF9 Gene

mRNA expression in normal human tissues for TNFSF9 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNFSF9 Gene

SOURCE GeneReport for Unigene cluster for TNFSF9 Gene Hs.1524

mRNA Expression by UniProt/SwissProt for TNFSF9 Gene

Tissue specificity: Expressed in brain, placenta, lung, skeletal muscle and kidney
genes like me logo Genes that share expressions with TNFSF9: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Expression partners for TNFSF9 Gene

Orthologs for TNFSF9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TNFSF9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNFSF9 35
  • 63.62 (n)
  • 50.62 (a)
  • 51 (a)
(Canis familiaris)
Mammalia TNFSF9 35
  • 69.92 (n)
  • 60.47 (a)
  • 57 (a)
(Mus musculus)
Mammalia Tnfsf9 16
Tnfsf9 36
  • 27 (a)
(Monodelphis domestica)
Mammalia TNFSF9 36
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia TNFSF9 36
  • 35 (a)
Species with no ortholog for TNFSF9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF9 Gene

Gene Tree for TNFSF9 (if available)
Gene Tree for TNFSF9 (if available)

Paralogs for TNFSF9 Gene

No data available for Paralogs for TNFSF9 Gene

Variants for TNFSF9 Gene

Sequence variations from dbSNP and Humsavar for TNFSF9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs348337 -- 6,530,645(+) ATCTC(C/T)TTCCA upstream-variant-2KB, intron-variant
rs348389 -- 6,535,626(+) GCCTC(C/T)ACCTC utr-variant-3-prime
rs424264 -- 6,532,300(+) gtgtt(C/G)gtgtt intron-variant
rs442511 - 6,531,085(+) GGCCT(C/G)CCGCG reference, missense
rs447087 -- 6,532,411(-) aaaca(A/C)acacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFSF9 Gene

Variant ID Type Subtype PubMed ID
nsv910916 CNV Loss 21882294
nsv833727 CNV Loss 17160897
nsv910923 CNV Loss 21882294
nsv833728 CNV Loss 17160897
esv2668569 CNV Deletion 23128226
esv22875 CNV Loss 19812545
nsv138022 CNV Insertion 16902084

Relevant External Links for TNFSF9 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF9 Gene

Disorders for TNFSF9 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TNFSF9 Gene in MalaCards »

(1) Disease for TNFSF9 Gene

(8) Novoseek inferred disease relationships for TNFSF9 Gene

Disease -log(P) Hits PubMed IDs
necrosis 47.7 17
tumors 43.7 33
solid tumor 21.7 1
multiple sclerosis 4.73 3
hiv infections 0 1

Relevant External Links for TNFSF9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TNFSF9: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for TNFSF9 Gene

Publications for TNFSF9 Gene

  1. The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily. (PMID: 20032458) Won E.Y. … Cho H.S. (J. Biol. Chem. 2010) 3 4 23
  2. Molecular and biological characterization of human 4-1BB and its ligand. (PMID: 8088337) Alderson M.R. … Goodwin R.G. (Eur. J. Immunol. 1994) 2 3 4
  3. Expression of costimulatory molecules (4-1BBL and Fas) and major histocompatibility class I chain-related A (MICA) in aortic tissue with Takayasu's arteritis. (PMID: 14752253) Seko Y. … Nagai R. (J. Vasc. Res. 2004) 3 23
  4. 4-1BB-ligand is regulated on human dendritic cells and induces the production of IL-12. (PMID: 14746806) Laderach D. … Galy A. (Cell. Immunol. 2003) 3 23
  5. TNFSF9 expression in primary biliary cirrhosis and its clinical significance. (PMID: 20303781) Xia R. … Zhong R. (Cytokine 2010) 3 23

Products for TNFSF9 Gene

Sources for TNFSF9 Gene

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