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TNFSF9 Gene

protein-coding   GIFtS: 59
GCID: GC19P006531

Tumor Necrosis Factor (Ligand) Superfamily, Member 9

  See TNFSF9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor (Ligand) Superfamily, Member 91 2     4-1BB Ligand2 3
Homolog Of Mouse 4-1BB-L1 2     4-1BB-L2
Receptor 4-1BB Ligand1 2     CD137L2
4-1BBL2 3     Tumor Necrosis Factor Ligand Superfamily Member 92

External Ids:    HGNC: 119391   Entrez Gene: 87442   Ensembl: ENSG000001256577   OMIM: 6061825   UniProtKB: P412733   

Export aliases for TNFSF9 gene to outside databases

Previous GC identifers: GC19P006625 GC19P006471 GC19P006482 GC19P006293


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFSF9 Gene:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This
transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a
costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen
presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from
resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene,
TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte
proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells.
This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell
interaction.(provided by RefSeq, Oct 2008)

GeneCards Summary for TNFSF9 Gene:
TNFSF9 (tumor necrosis factor (ligand) superfamily, member 9) is a protein-coding gene. Diseases associated with TNFSF9 include wegener's granulomatosis, and primary biliary cirrhosis. GO annotations related to this gene include tumor necrosis factor receptor binding and receptor binding.

UniProtKB/Swiss-Prot: TNFL9_HUMAN, P41273
Function: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May
have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and
B-cells/macrophages




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFSF9 gene promoter:
         TBP   Sp1   TFIID   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFSF9 promoter sequence
   Search Chromatin IP Primers for TNFSF9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFSF9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TNFSF9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFSF9 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P006531:  view genomic region     (about GC identifiers)

Start:
6,531,010 bp from pter      End:
6,535,939 bp from pter
Size:
4,930 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TNFL9_HUMAN, P41273 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 9  
Size: 254 amino acids; 26625 Da
Subunit: Homotrimer
1 PDB 3D structure from and Proteopedia for TNFSF9:
2X29 (3D)    
Secondary accessions: Q2M3S2

Explore the universe of human proteins at neXtProt for TNFSF9: NX_P41273

Explore proteomics data for TNFSF9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TNFSF9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003802.1  
    ENSEMBL proteins: 
     ENSP00000245817  

    TNFSF9 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TNFSF9

     
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    antibodies-online proteins for TNFSF9 (28 products) 

     
    antibodies-online peptides for TNFSF9

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TNFSF: Tumor necrosis factor (ligand) superfamily

    3 InterPro protein domains:
     IPR006052 TNF_dom
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR021184 TNF_CS

    Graphical View of Domain Structure for InterPro Entry P41273

    ProtoNet protein and cluster: P41273

    1 Blocks protein domain: IPB006052 Tumor Necrosis Factor

    UniProtKB/Swiss-Prot: TNFL9_HUMAN, P41273
    Similarity: Belongs to the tumor necrosis factor family


    Find genes that share domains with TNFSF9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNFL9_HUMAN, P41273
    Function: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May
    have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and
    B-cells/macrophages

         Genatlas biochemistry entry for TNFSF9:
    ,tumor necrosis factor (ligand) superfamily,member 9,inducible T cell antigen 4-1BB ligand

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS8088337
    GO:0005125cytokine activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding ----
    GO:0032813tumor necrosis factor receptor superfamily binding ----
         
    Find genes that share ontologies with TNFSF9           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tnfsf9):
     hematopoietic system  immune system 

    Find genes that share phenotypes with TNFSF9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tnfsf9tm1Thw for TNFSF9

       genOway: Develop your customized and physiologically relevant rodent model for TNFSF9

    miRNA
    Products:
        
    miRTarBase miRNAs that target TNFSF9:
    hsa-mir-98-5p (MIRT027516), hsa-mir-335-5p (MIRT017011), hsa-mir-26b-5p (MIRT028983), hsa-mir-16-5p (MIRT001405)

    Block miRNA regulation of human, mouse, rat TNFSF9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNFSF9 (see all 22):
    hsa-let-7d hsa-miR-15a hsa-miR-202 hsa-let-7c hsa-let-7g hsa-miR-424 hsa-let-7a hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidTNFSF9 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNFL9_HUMAN, P41273: Membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TNFSF9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFSF9 About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    4Akt Signaling
    Akt Signaling0.60
    p38 Signaling0.60
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with TNFSF9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFSF9
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFSF9 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Rho Family GTPases
    MIF Mediated Glucocorticoid Regulation

    3 Sino Biological Pathways for TNFSF9
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1 Kegg Pathway  (Kegg details for TNFSF9):
        Cytokine-cytokine receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFSF9: 
              TNF Ligands & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFSF9

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TNFSF9 (P412733 ENSP000002458174) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF9Q070113, ENSP000003667294I2D: score=2 STRING: ENSP00000366729
    TRAF1Q130773, ENSP000003629944I2D: score=3 STRING: ENSP00000362994
    TRAF2Q129333, ENSP000002476684I2D: score=3 STRING: ENSP00000247668
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS8088337
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS8088337
    GO:0007267cell-cell signaling TAS8088337
    GO:0008283cell proliferation TAS8088337

    Find genes that share ontologies with TNFSF9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFSF9 (TNFL9)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNFSF9 gene: 
    NM_003811.3  

    Unigene Cluster for TNFSF9:

    Tumor necrosis factor (ligand) superfamily, member 9
    Hs.1524  [show with all ESTs]
    Unigene Representative Sequence: NM_003811
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000245817(uc002mfh.2)
    miRNA
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    hsa-let-7d hsa-miR-15a hsa-miR-202 hsa-let-7c hsa-let-7g hsa-miR-424 hsa-let-7a hsa-miR-24
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    Additional mRNA sequence: 

    AK313999.1 BC104805.1 BC104807.1 U03398.1 

    1 DOTS entry:

    DT.204520 

    Selected AceView cDNA sequences (see all 32):

    BM790119 CA426922 BU631673 BM856840 CR624086 BQ890400 BM744249 AI142376 
    CA310489 BQ722355 AL555486 BU502747 U03398 AI357267 BX372166 CA307086 
    AA493857 BM782490 BX107825 NM_003811 BM545061 BV198776 AL577974 AL555984 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFSF9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGTACAAT
    TNFSF9 Expression
    About this image

    TNFSF9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFSF9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1524

    UniProtKB/Swiss-Prot: TNFL9_HUMAN, P41273
    Tissue specificity: Expressed in brain, placenta, lung, skeletal muscle and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFSF9: 
              TNF Ligands & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TNFSF9 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfsf95 tumor necrosis factor (ligand) superfamily, member more   --   17 (29.67 cM) 57105385 


    ENSEMBL Gene Tree for TNFSF9 (if available)
    TreeFam Gene Tree for TNFSF9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFSF9 (see all 201)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877213331,2
    --6291217(+) CTTCTA/TGGCCC 1 -- us2k10--------
    rs723564191,2
    C--6459147(+) CCCCT-/TTCC  
            
    TTCCT
    1 -- int10--------
    rs739207001,2
    C,F--6529027(+) GCCCCG/AGATTG 1 -- us2k12Minor allele frequency- A:0.10WA 120
    rs1473773041,2
    --6529168(+) CCTGCC/TGGGAA 1 -- us2k10--------
    rs1160750871,2
    F--6529599(+) ATGGAG/CAGAGA 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1395877211,2
    C--6529614(+) GATAAC/TGGAGC 1 -- us2k10--------
    rs1926542601,2
    C--6529636(+) AGAGTC/GAGAGA 1 -- us2k10--------
    rs1857036861,2
    --6529670(+) TGACAC/TAGATA 1 -- us2k10--------
    rs1891594221,2
    --6529729(+) AGAGAC/TAACAG 1 -- us2k10--------
    rs1463743801,2
    C--6529739(+) GAGCC-/AGA   
       GACAG
    AGAGA
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TNFSF9 (6531010 - 6535939 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TNFSF9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668569CNV Deletion23128226
    nsv138022CNV Insertion16902084
    nsv910916CNV Loss21882294
    esv22875CNV Loss19812545
    nsv833728CNV Loss17160897
    nsv910923CNV Loss21882294
    nsv833727CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFSF9
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFSF9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606182    OMIM disorders: --

    2 diseases for TNFSF9:    
    About MalaCards
    wegener's granulomatosis    primary biliary cirrhosis


    Find genes that share disorders with TNFSF9           About GenesLikeMe

    8 Novoseek inferred disease relationships for TNFSF9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 47.7 21 9045669 (2), 8656679 (1), 16547002 (1), 19233196 (1) (see all 16)
    tumors 43.7 43 10946324 (3), 18026115 (2), 20463597 (2), 9045669 (2) (see all 28)
    solid tumor 21.7 1 19225975 (1)
    multiple sclerosis 4.73 3 16513684 (2), 16970683 (1)
    hiv infections 0 1 16272290 (1)
    influenza 0 1 14745033 (1)
    carcinoma 0 3 10946324 (2), 11564827 (1)
    cancer 0 7 14671675 (1), 14614331 (1), 16285508 (1), 12594573 (1) (see all 6)

    Genetic Association Database (GAD): TNFSF9
    Human Genome Epidemiology (HuGE) Navigator: TNFSF9 (10 documents)

    Export disorders for TNFSF9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFSF9 gene, integrated from 10 sources (see all 129):
    (articles sorted by number of sources associating them with TNFSF9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular and biological characterization of human 4-1BB and its ligand. (PubMed id 8088337)1, 2, 3 Alderson M.R.... Goodwin R.G. (Eur. J. Immunol. 1994)
    2. The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily. (PubMed id 20032458)1, 2, 9 Won E.Y.... Cho H.S. (J. Biol. Chem. 2010)
    3. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    6. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    7. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    8. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. (PubMed id 8405064)1, 3 Goodwin R.G....Jenkins N.A. (Eur. J. Immunol. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8744 HGNC: 11939 AceView: TNFSF9 Ensembl:ENSG00000125657 euGenes: HUgn8744
    ECgene: TNFSF9 Kegg: 8744 H-InvDB: TNFSF9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNFSF9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFSF9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFSF9 gene:
    Search GeneIP for patents involving TNFSF9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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