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Aliases for TNFSF9 Gene

Aliases for TNFSF9 Gene

  • TNF Superfamily Member 9 2 3
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 9 2 3
  • Tumor Necrosis Factor Superfamily Member 9 3 5
  • Homolog Of Mouse 4-1BB-L 2 3
  • Receptor 4-1BB Ligand 2 3
  • 4-1BB Ligand 3 4
  • 4-1BBL 3 4
  • Tumor Necrosis Factor Ligand Superfamily Member 9 3
  • Tumor Necrosis Factor Ligand 5A 3
  • 4-1BB-L 3
  • CD137L 3
  • TNLG5A 3

External Ids for TNFSF9 Gene

Previous GeneCards Identifiers for TNFSF9 Gene

  • GC19P006625
  • GC19P006471
  • GC19P006482
  • GC19P006293

Summaries for TNFSF9 Gene

Entrez Gene Summary for TNFSF9 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]

GeneCards Summary for TNFSF9 Gene

TNFSF9 (TNF Superfamily Member 9) is a Protein Coding gene. Among its related pathways are TRAF Pathway and Innate Immune System. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding.

UniProtKB/Swiss-Prot for TNFSF9 Gene

  • Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF9 Gene

Genomics for TNFSF9 Gene

Regulatory Elements for TNFSF9 Gene

Enhancers for TNFSF9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G006575 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8.3 +49.9 49885 5.5 HDGF PKNOX1 ARNT WRNIP1 TCF12 GATA2 ZNF207 FOS CAVIN1 JUNB TNFSF14 TNFSF9 CD70 DENND1C ZNF557 GC19P006580 GC19M006573 ENSG00000199223
GH19G006587 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.7 +59.2 59206 1.5 HDGF PKNOX1 ARNT WRNIP1 YBX1 ZNF48 ZNF207 MCM3 NCOA1 JUNB CD70 TNFSF9 DENND1C ZNF557 GC19P006581 RPL7P50
GH19G006517 1.7 FANTOM5 Ensembl ENCODE dbSUPER 3.6 -10.3 -10287 1.1 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 YBX1 YY1 ZNF143 RELB ETV6 CD70 TNFSF9 RFX2 TUBB4A
GH19G006592 1.4 FANTOM5 ENCODE dbSUPER 4.1 +64.0 64007 0.7 HDGF ZNF335 ZNF143 RELB ETV6 IKZF2 CREM JUNB GATAD2B TBX21 CD70 TNFSF9 DENND1C ZNF557 RPL7P50 GC19P006581
GH19G006674 1.9 FANTOM5 Ensembl ENCODE dbSUPER 1.8 +146.5 146545 1.1 HDGF PKNOX1 CREB3L1 YBX1 ELK1 ZNF143 ZNF207 FOS ZNF548 KDM4B TNFSF14 C3 GPR108 TRIP10 XAB2 ZNF557 ADGRE1 VAV1 TNFSF9 DENND1C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFSF9 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNFSF9 Gene

6,528,562 bp from pter
6,535,928 bp from pter
7,367 bases
Plus strand

Genomic View for TNFSF9 Gene

Genes around TNFSF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF9 Gene

Proteins for TNFSF9 Gene

  • Protein details for TNFSF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor ligand superfamily member 9
    Protein Accession:
    Secondary Accessions:
    • Q2M3S2

    Protein attributes for TNFSF9 Gene

    254 amino acids
    Molecular mass:
    26625 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for TNFSF9 Gene

neXtProt entry for TNFSF9 Gene

Post-translational modifications for TNFSF9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNFSF9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFSF9 (4-1BB Ligand/TNFSF9)
  • Cloud-Clone Corp. Antibodies for TNFSF9

Protein Products

No data available for DME Specific Peptides for TNFSF9 Gene

Domains & Families for TNFSF9 Gene

Gene Families for TNFSF9 Gene

Protein Domains for TNFSF9 Gene

Suggested Antigen Peptide Sequences for TNFSF9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tumor necrosis factor family.
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF9: view

Function for TNFSF9 Gene

Molecular function for TNFSF9 Gene

GENATLAS Biochemistry:
,tumor necrosis factor (ligand) superfamily,member 9,inducible T cell antigen 4-1BB ligand
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.

Gene Ontology (GO) - Molecular Function for TNFSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8088337
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0032813 tumor necrosis factor receptor superfamily binding IBA --
genes like me logo Genes that share ontologies with TNFSF9: view
genes like me logo Genes that share phenotypes with TNFSF9: view

Animal Model Products

CRISPR Products

miRNA for TNFSF9 Gene

miRTarBase miRNAs that target TNFSF9

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFSF9 Gene

Localization for TNFSF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF9 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF9 gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TNFSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFSF9: view

Pathways & Interactions for TNFSF9 Gene

genes like me logo Genes that share pathways with TNFSF9: view

Gene Ontology (GO) - Biological Process for TNFSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 8088337
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 8088337
GO:0007267 cell-cell signaling TAS 8088337
GO:0008283 cell proliferation TAS 8088337
genes like me logo Genes that share ontologies with TNFSF9: view

No data available for SIGNOR curated interactions for TNFSF9 Gene

Drugs & Compounds for TNFSF9 Gene

No Compound Related Data Available

Transcripts for TNFSF9 Gene

mRNA/cDNA for TNFSF9 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFSF9 Gene

Tumor necrosis factor (ligand) superfamily, member 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF9 Gene

No ASD Table

Relevant External Links for TNFSF9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFSF9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFSF9 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFSF9 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFSF9 Gene:


SOURCE GeneReport for Unigene cluster for TNFSF9 Gene:


mRNA Expression by UniProt/SwissProt for TNFSF9 Gene:

Tissue specificity: Expressed in brain, placenta, lung, skeletal muscle and kidney.

Evidence on tissue expression from TISSUES for TNFSF9 Gene

  • Lung(4.2)
  • Blood(2.4)
  • Spleen(2.2)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with TNFSF9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF9 Gene

Orthologs for TNFSF9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TNFSF9 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TNFSF9 34 35
  • 69.92 (n)
(Bos Taurus)
Mammalia TNFSF9 35 34
  • 63.62 (n)
(Ornithorhynchus anatinus)
Mammalia TNFSF9 35
  • 35 (a)
(Monodelphis domestica)
Mammalia TNFSF9 35
  • 34 (a)
(Mus musculus)
Mammalia Tnfsf9 35
  • 27 (a)
Species where no ortholog for TNFSF9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF9 Gene

Gene Tree for TNFSF9 (if available)
Gene Tree for TNFSF9 (if available)

Paralogs for TNFSF9 Gene

No data available for Paralogs for TNFSF9 Gene

Variants for TNFSF9 Gene

Sequence variations from dbSNP and Humsavar for TNFSF9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000491087 -- 6,532,534(+) GTGTG(-/TGTT)CGTGT intron-variant
rs1000586506 -- 6,536,122(+) GGGAG(A/C)GGAGG downstream-variant-500B
rs1000799869 -- 6,531,655(+) GAGGA(A/G)ACCCC intron-variant
rs1001166752 -- 6,531,917(+) CGGGG(A/G)ACCCT intron-variant
rs1001753441 -- 6,530,891(+) AGAGT(C/T)ACGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TNFSF9 Gene

Variant ID Type Subtype PubMed ID
dgv1700n106 CNV deletion 24896259
esv22875 CNV loss 19812545
esv2668569 CNV deletion 23128226
nsv1072314 CNV deletion 25765185
nsv138022 CNV insertion 16902084
nsv833727 CNV loss 17160897
nsv833728 CNV loss 17160897

Variation tolerance for TNFSF9 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFSF9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF9 Gene

Disorders for TNFSF9 Gene

Relevant External Links for TNFSF9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TNFSF9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFSF9 Gene

Publications for TNFSF9 Gene

  1. The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily. (PMID: 20032458) Won E.Y. … Cho H.S. (J. Biol. Chem. 2010) 3 4 22 64
  2. Molecular and biological characterization of human 4-1BB and its ligand. (PMID: 8088337) Alderson M.R. … Goodwin R.G. (Eur. J. Immunol. 1994) 2 3 4 64
  3. TNFSF9 expression in primary biliary cirrhosis and its clinical significance. (PMID: 20303781) Xia R. … Zhong R. (Cytokine 2010) 3 22 64
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 64

Products for TNFSF9 Gene

Sources for TNFSF9 Gene

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