Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TNFSF8 Gene

Aliases for TNFSF8 Gene

  • TNF Superfamily Member 8 2 3 5
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 8 2 3
  • CD153 Antigen 3 4
  • CD30 Ligand 3 4
  • CD30LG 3 4
  • CD30-L 3 4
  • CD30L 3 4
  • Tumor Necrosis Factor Ligand Superfamily Member 8 3
  • Tumor Necrosis Factor Superfamily Member 8 3
  • Tumor Necrosis Factor Ligand 3A 3
  • CD30 Antigen Ligand 3
  • TNLG3A 3
  • CD153 3

External Ids for TNFSF8 Gene

Previous HGNC Symbols for TNFSF8 Gene

  • CD30LG

Previous GeneCards Identifiers for TNFSF8 Gene

  • GC09M108463
  • GC09M109397
  • GC09M111118
  • GC09M113041
  • GC09M114744
  • GC09M116704
  • GC09M117656
  • GC09M087269

Summaries for TNFSF8 Gene

Entrez Gene Summary for TNFSF8 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for TNFSF8 Gene

TNFSF8 (TNF Superfamily Member 8) is a Protein Coding gene. Diseases associated with TNFSF8 include Lymphoma, Hodgkin, Classic and Anaplastic Large Cell Lymphoma. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor binding and tumor necrosis factor receptor binding.

UniProtKB/Swiss-Prot for TNFSF8 Gene

  • Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

Additional gene information for TNFSF8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF8 Gene

Genomics for TNFSF8 Gene

GeneHancer (GH) Regulatory Elements for TNFSF8 Gene

Promoters and enhancers for TNFSF8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I114927 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 580.9 +1.0 966 4.9 NONO SUZ12 ZNF195 RUNX3 TNFSF8 ATP6V1G1 TNFSF15 WHRN GC09P114903
GH09I114953 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 30.9 -24.0 -23959 2.5 JUN MAX CEBPG RFX5 SMARCC2 RCOR1 NFE2 FOSL2 FOS NFE2L2 TNFSF8 TNFSF15 ATP6V1G1 WHRN GC09M115052
GH09I114897 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 27.6 +30.1 30050 6.4 RFX1 ZNF449 POLR2A RUNX3 GABPA SPI1 GC09P114903 TNFSF8 TNFSF15 ATP6V1G1 WHRN LOC645266
GH09I114989 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 27.2 -58.8 -58813 0.8 JUN MAX EBF1 BATF RAD21 RFX5 RELA SMARCC2 RCOR1 ATF7 TNFSF8 TNFSF15 ATP6V1G1 WHRN GC09M115052
GH09I115008 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 27.2 -78.2 -78180 1 SMARCC1 ZNF362 JUN CEBPB RAD21 MAFF JUND ZNF629 STAT3 SMC3 TNFSF8 TNFSF15 ATP6V1G1 GC09M115052
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFSF8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFSF8 gene promoter:

Genomic Locations for TNFSF8 Gene

Genomic Locations for TNFSF8 Gene
37,253 bases
Minus strand

Genomic View for TNFSF8 Gene

Genes around TNFSF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF8 Gene

Proteins for TNFSF8 Gene

  • Protein details for TNFSF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor ligand superfamily member 8
    Protein Accession:
    Secondary Accessions:
    • O43404

    Protein attributes for TNFSF8 Gene

    234 amino acids
    Molecular mass:
    26017 Da
    Quaternary structure:
    • Homotrimer.

neXtProt entry for TNFSF8 Gene

Post-translational modifications for TNFSF8 Gene

  • Glycosylation at isoforms=81, isoforms=109, isoforms=153, posLast=189189, and isoforms=201

Other Protein References for TNFSF8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFSF8 Gene

Domains & Families for TNFSF8 Gene

Gene Families for TNFSF8 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Predicted membrane proteins

Protein Domains for TNFSF8 Gene

Suggested Antigen Peptide Sequences for TNFSF8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tumor necrosis factor family.
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF8: view

Function for TNFSF8 Gene

Molecular function for TNFSF8 Gene

GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 8,CD30 ligand on surface of T cells
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

Phenotypes From GWAS Catalog for TNFSF8 Gene

Gene Ontology (GO) - Molecular Function for TNFSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8391931
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
genes like me logo Genes that share ontologies with TNFSF8: view
genes like me logo Genes that share phenotypes with TNFSF8: view

Animal Models for TNFSF8 Gene

MGI Knock Outs for TNFSF8:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFSF8 Gene

Localization for TNFSF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF8 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF8 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TNFSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8391931
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFSF8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFSF8 Gene

Pathways & Interactions for TNFSF8 Gene

genes like me logo Genes that share pathways with TNFSF8: view

Interacting Proteins for TNFSF8 Gene

Gene Ontology (GO) - Biological Process for TNFSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 8391931
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 8391931
GO:0007267 cell-cell signaling TAS 8391931
GO:0008283 cell proliferation TAS 8391931
genes like me logo Genes that share ontologies with TNFSF8: view

No data available for SIGNOR curated interactions for TNFSF8 Gene

Drugs & Compounds for TNFSF8 Gene

No Compound Related Data Available

Transcripts for TNFSF8 Gene

mRNA/cDNA for TNFSF8 Gene

Unigene Clusters for TNFSF8 Gene

Tumor necrosis factor (ligand) superfamily, member 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF8 Gene

No ASD Table

Relevant External Links for TNFSF8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFSF8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFSF8 Gene

mRNA differential expression in normal tissues according to GTEx for TNFSF8 Gene

This gene is overexpressed in Whole Blood (x20.8) and Spleen (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of TNFSF8 Gene:


SOURCE GeneReport for Unigene cluster for TNFSF8 Gene:


Evidence on tissue expression from TISSUES for TNFSF8 Gene

  • Lymph node(2.3)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with TNFSF8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF8 Gene

Orthologs for TNFSF8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFSF8 33 34
  • 99.57 (n)
(Canis familiaris)
Mammalia TNFSF8 33 34
  • 86.18 (n)
(Bos Taurus)
Mammalia TNFSF8 33 34
  • 85.47 (n)
(Mus musculus)
Mammalia Tnfsf8 33 16 34
  • 78.83 (n)
(Rattus norvegicus)
Mammalia Tnfsf8 33
  • 77.54 (n)
(Monodelphis domestica)
Mammalia TNFSF8 34
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia TNFSF8 34
  • 55 (a)
(Gallus gallus)
Aves TNFSF8 33 34
  • 50.58 (n)
(Anolis carolinensis)
Reptilia TNFSF8 34
  • 32 (a)
Species where no ortholog for TNFSF8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF8 Gene

Gene Tree for TNFSF8 (if available)
Gene Tree for TNFSF8 (if available)

Paralogs for TNFSF8 Gene

No data available for Paralogs for TNFSF8 Gene

Variants for TNFSF8 Gene

Sequence variations from dbSNP and Humsavar for TNFSF8 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000084691 -- 114,893,685(-) G/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000198621 -- 114,898,834(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000198727 -- 114,906,501(-) G/A/T intron_variant
rs1000254033 -- 114,913,239(-) T/A intron_variant
rs1000375231 -- 114,899,857(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFSF8 Gene

Variant ID Type Subtype PubMed ID
nsv6680 CNV deletion 18451855
nsv7434 OTHER inversion 18451855
nsv831695 CNV gain 17160897
nsv950931 CNV duplication 24416366

Variation tolerance for TNFSF8 Gene

Residual Variation Intolerance Score: 41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFSF8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF8 Gene

Disorders for TNFSF8 Gene

MalaCards: The human disease database

(7) MalaCards diseases for TNFSF8 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFSF8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNFSF8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF8 Gene

Publications for TNFSF8 Gene

  1. Characterisation of the human CD30 ligand gene structure. (PMID: 9349718) Croager EJ … Abraham LJ (Biochimica et biophysica acta 1997) 2 3 4 22 58
  2. Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population. (PMID: 11960307) Ahmed S … Hara T (Genes and immunity 2002) 3 22 44 58
  3. CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. (PMID: 8391931) Smith CA … Jenkins NA (Cell 1993) 2 3 4 58
  4. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee KM … Lan Q (American journal of hematology 2010) 3 44 58
  5. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PMID: 19573080) Liang XS … Goldin LR (British journal of haematology 2009) 3 44 58

Products for TNFSF8 Gene

Sources for TNFSF8 Gene

Loading form....