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Aliases for TNFSF8 Gene

Aliases for TNFSF8 Gene

  • Tumor Necrosis Factor (Ligand) Superfamily, Member 8 2 3
  • CD153 Antigen 3 4
  • CD30 Ligand 3 4
  • CD30LG 3 4
  • CD30-L 3 4
  • CD30L 3 4
  • CD30 Antigen Ligand 3
  • CD153 3

External Ids for TNFSF8 Gene

Previous HGNC Symbols for TNFSF8 Gene

  • CD30LG

Previous GeneCards Identifiers for TNFSF8 Gene

  • GC09M108463
  • GC09M109397
  • GC09M111118
  • GC09M113041
  • GC09M114744
  • GC09M116704
  • GC09M117656
  • GC09M087269

Summaries for TNFSF8 Gene

Entrez Gene Summary for TNFSF8 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for TNFSF8 Gene

TNFSF8 (Tumor Necrosis Factor (Ligand) Superfamily, Member 8) is a Protein Coding gene. Diseases associated with TNFSF8 include hodgkin lymphoma and anaplastic large cell lymphoma. Among its related pathways are Akt Signaling and PAK Pathway. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding.

UniProtKB/Swiss-Prot for TNFSF8 Gene

  • Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF8 Gene

Genomics for TNFSF8 Gene

Regulatory Elements for TNFSF8 Gene

Genomic Location for TNFSF8 Gene

114,893,343 bp from pter
114,930,595 bp from pter
37,253 bases
Minus strand

Genomic View for TNFSF8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFSF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF8 Gene

Proteins for TNFSF8 Gene

  • Protein details for TNFSF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor ligand superfamily member 8
    Protein Accession:
    Secondary Accessions:
    • O43404

    Protein attributes for TNFSF8 Gene

    234 amino acids
    Molecular mass:
    26017 Da
    Quaternary structure:
    • Homotrimer.

neXtProt entry for TNFSF8 Gene

Proteomics data for TNFSF8 Gene at MOPED

Post-translational modifications for TNFSF8 Gene

  • Glycosylation at Asn 81, Asn 109, Asn 153, Asn 189, and Asn 201
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFSF8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFSF8 (CD30 Ligand/TNFSF8)

No data available for DME Specific Peptides for TNFSF8 Gene

Domains & Families for TNFSF8 Gene

Gene Families for TNFSF8 Gene

Protein Domains for TNFSF8 Gene

Suggested Antigen Peptide Sequences for TNFSF8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tumor necrosis factor family.
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF8: view

Function for TNFSF8 Gene

Molecular function for TNFSF8 Gene

GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 8,CD30 ligand on surface of T cells
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells

Gene Ontology (GO) - Molecular Function for TNFSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8391931
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TNFSF8: view
genes like me logo Genes that share phenotypes with TNFSF8: view

Animal Models for TNFSF8 Gene

MGI Knock Outs for TNFSF8:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFSF8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNFSF8 Gene

Localization for TNFSF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF8 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for TNFSF8 Gene COMPARTMENTS Subcellular localization image for TNFSF8 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TNFSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005887 integral component of plasma membrane TAS 8391931
GO:0016020 membrane --
genes like me logo Genes that share ontologies with TNFSF8: view

Pathways & Interactions for TNFSF8 Gene

genes like me logo Genes that share pathways with TNFSF8: view

Pathways by source for TNFSF8 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for TNFSF8 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000223795 P32971-TNFL8_HUMAN for TNFSF8 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TNFSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 8391931
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 8391931
GO:0007267 cell-cell signaling TAS 8391931
GO:0008283 cell proliferation TAS 8391931
genes like me logo Genes that share ontologies with TNFSF8: view

No data available for SIGNOR curated interactions for TNFSF8 Gene

Drugs & Compounds for TNFSF8 Gene

No Compound Related Data Available

Transcripts for TNFSF8 Gene

mRNA/cDNA for TNFSF8 Gene

Unigene Clusters for TNFSF8 Gene

Tumor necrosis factor (ligand) superfamily, member 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFSF8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF8 Gene

No ASD Table

Relevant External Links for TNFSF8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFSF8 Gene

mRNA expression in normal human tissues for TNFSF8 Gene

mRNA differential expression in normal tissues according to GTEx for TNFSF8 Gene

This gene is overexpressed in Whole Blood (x20.8) and Spleen (x5.0).

SOURCE GeneReport for Unigene cluster for TNFSF8 Gene Hs.494901

genes like me logo Genes that share expression patterns with TNFSF8: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TNFSF8 Gene

Orthologs for TNFSF8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNFSF8 35
  • 85.47 (n)
  • 81.2 (a)
  • 81 (a)
(Canis familiaris)
Mammalia TNFSF8 35
  • 86.18 (n)
  • 81.62 (a)
  • 82 (a)
(Mus musculus)
Mammalia Tnfsf8 35
  • 78.83 (n)
  • 71.67 (a)
Tnfsf8 16
Tnfsf8 36
  • 70 (a)
(Pan troglodytes)
Mammalia TNFSF8 35
  • 99.57 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tnfsf8 35
  • 77.54 (n)
  • 70.39 (a)
(Monodelphis domestica)
Mammalia TNFSF8 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia TNFSF8 36
  • 55 (a)
(Gallus gallus)
Aves TNFSF8 35
  • 50.58 (n)
  • 36.84 (a)
  • 35 (a)
(Anolis carolinensis)
Reptilia TNFSF8 36
  • 32 (a)
Species with no ortholog for TNFSF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF8 Gene

Gene Tree for TNFSF8 (if available)
Gene Tree for TNFSF8 (if available)

Paralogs for TNFSF8 Gene

No data available for Paralogs for TNFSF8 Gene

Variants for TNFSF8 Gene

Sequence variations from dbSNP and Humsavar for TNFSF8 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2974 -- 114,901,892(+) TCCCT(C/T)TCATC utr-variant-3-prime, intron-variant
rs927373 -- 114,913,533(+) GTGCC(A/G)AAGAA intron-variant
rs927374 -- 114,917,090(+) CATGG(C/G)CAAGG intron-variant
rs1006025 -- 114,928,921(+) GAGTA(C/T)TTGGC intron-variant
rs1006026 -- 114,928,990(+) TAGGC(A/G)CTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFSF8 Gene

Variant ID Type Subtype PubMed ID
nsv893750 CNV Loss 21882294
nsv831695 CNV Gain 17160897
nsv893767 CNV Gain 21882294
nsv7434 OTHER Inversion 18451855
nsv6680 CNV Loss 18451855

Variation tolerance for TNFSF8 Gene

Residual Variation Intolerance Score: 41.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFSF8 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF8 Gene

Disorders for TNFSF8 Gene

MalaCards: The human disease database

(7) MalaCards diseases for TNFSF8 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
hodgkin lymphoma
  • hodgkin's lymphoma
anaplastic large cell lymphoma
  • alcl
acute myocarditis
takayasu's arteritis
  • takayasu's disease
  • hairy cell leukaemia variant
- elite association

Relevant External Links for TNFSF8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TNFSF8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF8 Gene

Publications for TNFSF8 Gene

  1. Characterisation of the human CD30 ligand gene structure. (PMID: 9349718) Croager E.J. … Abraham L.J. (Biochim. Biophys. Acta 1997) 2 23 67
  2. Targeting CD30/CD30L in oncology and autoimmune and inflammatory diseases. (PMID: 19760074) Oflazoglu E. … Gerber H. (Adv. Exp. Med. Biol. 2009) 23 67
  3. The capacity of the TNF family members 4-1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells. (PMID: 18825741) Kober J. … Steinberger P. (Eur. J. Immunol. 2008) 23 67
  4. Ingested (oral) SIRS peptide 1-21 inhibits acute EAE by inducing Th2-like cytokines. (PMID: 17196668) Brod S.A. … Hood Z. (J. Neuroimmunol. 2007) 23 67
  5. Increase in CD30 ligand/CD153 and TNF-alpha expressing mast cells in basal cell carcinoma. (PMID: 17268792) Diaconu N.C. … Harvima I.T. (Cancer Immunol. Immunother. 2007) 23 67

Products for TNFSF8 Gene

Sources for TNFSF8 Gene

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