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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFSF8 Gene

protein-coding   GIFtS: 60
GCID: GC09M117656

tumor necrosis factor (ligand) superfamily, member 8


(Previous symbol: CD30LG)
 Explore 34 diseases affiliated with
TNFSF8 via our new
 Human Malady Compendium 
Biological research products
for TNFSF8
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tumor Necrosis Factor (Ligand) Superfamily, Member 81 2     CD153 Antigen2 3
CD30LG1 2 3 5     CD30 Ligand2 3
CD30L2 3 5     CD30 Antigen Ligand2
CD1531 2     Tumor Necrosis Factor Ligand Superfamily Member 82
CD30-L2 3     

External Ids:    HGNC: 119381   Entrez Gene: 9442   Ensembl: ENSG000001069527   OMIM: 6038755   UniProtKB: P329713   

Export aliases for TNFSF8 gene to outside databases

Previous GC identifers: GC09M108463 GC09M109397 GC09M111118 GC09M113041 GC09M114744 GC09M116704 GC09M087269


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFSF8:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This
cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related
hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in
modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while
to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities
of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some
non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. (provided
by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: TNFL8_HUMAN, P32971
Function: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFSF8 gene promoter:
         NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFSF8 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFSF8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFSF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q33

TNFSF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFSF8 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M117656:  view genomic region     (about GC identifiers)

Start:
117,656,003 bp from pter      End:
117,692,770 bp from pter
Size:
36,768 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TNFL8_HUMAN, P32971 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 8  
Size: 234 amino acids; 26017 Da
Subunit: Homotrimer (Probable)
Subcellular location: Membrane; Single-pass type II membrane protein
Secondary accessions: O43404

Explore the universe of human proteins at neXtProt for TNFSF8: NX_P32971

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P32971

  • TNFSF8 Protein expression data from MOPED and PaxDb:    About this image 
    TNFSF8 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001235.1  NP_001239219.1  

    ENSEMBL proteins: 
     ENSP00000223795  

    Human Recombinant Protein Products for TNFSF8: 
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    Uscn Proteins for TNFSF8

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005887integral to plasma membrane TAS8391931

    TNFSF8 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TNFSF8 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR006052 TNF
     IPR021185 TNF_CD30_ligand_type
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR021184 TNF_CS

    Graphical View of Domain Structure for InterPro Entry P32971

    ProtoNet protein and cluster: P32971

    1 Blocks protein family: IPB006052 Tumor Necrosis Factor

    UniProtKB/Swiss-Prot: TNFL8_HUMAN, P32971
    Similarity: Belongs to the tumor necrosis factor family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNFL8_HUMAN, P32971
    Function: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells

         Genatlas biochemistry entry for TNFSF8:
    tumor necrosis factor (ligand) superfamily,member 8,CD30 ligand on surface of T cells

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS8391931
    GO:0005125cytokine activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--
         
    TNFSF8 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tnfsf8):
     immune system 

    TNFSF8 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Tnfsf8tm1Pod for TNFSF8
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TNFSF8 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTNFSF8 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/9 pathways (see all 9)
    PEDF Induced Signaling1.00
    RAR-Gamma-RXR-Alpha Degradation0.54
    MIF Mediated Glucocorticoid Regulation0.73
    STAT3 Pathway0.47
    MIF Regulation of Innate Immune Cells0.71
    Endothelin-1 Signaling Pathway0.44
    IL-6 Pathway0.61
    Cytokine-cytokine receptor interaction0.26
    2Rho Family GTPases
    Rho Family GTPases1.00
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    3PAK Pathway
    PAK Pathway1.00
    Antioxidant Action of Vitamin-C0.56
    4Akt Signaling
    Akt Signaling1.00
    p38 Signaling0.60
    5Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway0.46
    Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TNFSF8
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

    1 R&D Systems Pathway for TNFSF8
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    5/16 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFSF8 (see all 16)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Rho Family GTPases
    MIF Mediated Glucocorticoid Regulation

    1 GeneGo (Thomson Reuters) Pathway for TNFSF8
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway


    1         Kegg Pathway  (Kegg details for TNFSF8):
        Cytokine-cytokine receptor interaction


    TNFSF8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFSF8

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TNFSF8 (P329713 ENSP000002237954) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF8P289083, ENSP000002639324I2D: score=2 STRING: ENSP00000263932
    ANGP039503, ENSP000003367624I2D: score=1 STRING: ENSP00000336762
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006917induction of apoptosis TAS8391931
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS8391931
    GO:0007267cell-cell signaling TAS8391931
    GO:0008283cell proliferation TAS8391931

    TNFSF8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFSF8
    Search CenterWatch for drugs/clinical trials and news about TNFSF8 / TNFL8 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNFSF8 gene (2 alternative transcripts): 
    NM_001244.3  NM_001252290.1  

    Unigene Cluster for TNFSF8:

    Tumor necrosis factor (ligand) superfamily, member 8
    Hs.494901  [show with all ESTs]
    Unigene Representative Sequence: NM_001244
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474301(uc022bmi.1) ENST00000223795(uc004bji.2)

    miRNA
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    hsa-miR-4283 hsa-miR-1237 hsa-miR-1183 hsa-miR-378*
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    Additional cDNA sequence: 

    AF086214.1 AK313619.1 BC093630.1 BC111939.1 L09753.1 

    4 DOTS entries:

    DT.406506  DT.209534  DT.100644125  DT.40118583 

    24/41 AceView cDNA sequences (see all 41):

    NM_001244 AF086214 BG231841 F02561 AI734260 BX103824 CF541382 AI569927 
    AA287261 BG232102 BX108999 W02699 AI914536 BG230605 AI668671 N95225 
    AA287260 AW449271 AA748015 AI140118 AL583443 AJ705504 BX104360 L09753 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFSF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGCAGGAAT
    TNFSF8 Expression
    About this image
    See TNFSF8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFSF8

    SOURCE GeneReport for Unigene cluster: Hs.494901
        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFSF8 (see all 6): 

              TNF Ligands & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TNFSF8 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfsf81 , 5 tumor necrosis factor (ligand) superfamily, member more1, 5 78.83(n)1
    71.67(a)1
      4 (34.06 cM)5
    219491  NM_009403.31  NP_033429.11 
     638313085 
    chicken
    (Gallus gallus)
    Aves TNFSF81 tumor necrosis factor (ligand) superfamily, member more 50.81(n)
    37(a)
      378930  NM_204409.1  NP_989740.1 


    ENSEMBL Gene Tree for TNFSF8 (if available)
    TreeFam Gene Tree for TNFSF8 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/691 NCBI SNPs in TNFSF8 are shown (see all 691    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11089831,2
    C,F,H--117655167(-) GATCAT/CGTTTT 1 -- ds500118Minor allele frequency- C:0.21NS EA NA WA CSA 2064
    rs1827043021,2
    --117655209(+) TGGTGA/GATTTG 1 -- ds50010--------
    rs1393492751,2
    --117655223(+) CTGAGA/GCCTTT 1 -- ds50010--------
    rs1432716151,2
    --117655369(+) CTCCCC/TTCTCA 1 -- ds50010--------
    rs1877755401,2
    --117655428(+) CTTTGC/TGGGAA 1 -- ds50010--------
    rs1474602931,2
    --117655463(+) GTGTTG/TTAAGT 1 -- ds50010--------
    rs1931191561,2
    --117655569(+) AACTCC/TGCCAT 1 -- ds50010--------
    rs1845651051,2
    --117655617(+) ATGAAA/TGTGGC 1 -- ds50010--------
    rs104358701,2
    C,F--117655707(+) AGTTCT/AAGACA 1 -- ut311Minor allele frequency- A:0.15NA 120
    rs1161021731,2
    F--117655820(+) ACTTTA/GAAGCA 1 -- ut311Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for TNFSF8 (117656003 - 117692770 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TNFSF8: --
    Human Gene Mutation Database (HGMD): TNFSF8

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TNFSF8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TNFSF8 for disorders           About GeneDecksing

    OMIM gene information: 603875    OMIM disorders: --

    20/34 diseases for TNFSF8 (see all 34):    About MalaCards
    non-hodgkin lymphoma    hodgkin's lymphoma    spastic diplegia    anaplastic large cell lymphoma
    graft versus host disease    hypereosinophilic syndrome    leukemia/lymphoma    leukemia/lymphoma, t-cell
    lymphocytic leukemia    germ cell tumor    interstitial lung disease    spasticity
    basal cell carcinoma    chronic lymphocytic leukemia    lymphoblastic leukemia    acute myeloid leukemia
    herpes simplex    acute myocarditis    myeloid leukemia    leukemia

    1 disease from the University of Copenhagen DISEASES database for TNFSF8:
    Lymphoma

    10/16 Novoseek disease relationships for TNFSF8 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 69 10 9209650 (4), 7528856 (1), 8701986 (1), 10908157 (1) (see all 6)
    anaplastic large cell lymphoma 65.5 3 7528856 (1), 8701986 (1), 7527901 (1)
    necrosis 52.9 22 7527901 (2), 8186199 (1), 16547002 (1), 17219720 (1) (see all 17)
    spastic diplegia 52.8 3 9058727 (1), 10512160 (1)
    hypereosinophilic syndrome 52.7 2 8896393 (1)
    lymphocytic leukemia chronic b-cell 52.6 2 16270354 (1), 9058727 (1)
    leukemia hairy cell 45.9 1 9058727 (1)
    lymphoproliferative disorders 41.3 1 9058727 (1)
    tumors 33.7 26 19760074 (2), 9058727 (2), 7527901 (2), 15596049 (2) (see all 17)
    lymphoma non-hodgkins 26.5 2 7528856 (1), 9058727 (1)

    Genetic Association Database (GAD): TNFSF8
    Human Genome Epidemiology (HuGE) Navigator: TNFSF8 (10 documents)

    Export disorders for TNFSF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFSF8 gene, integrated from 9 sources (see all 78):
    (articles sorted by number of sources associating them with TNFSF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterisation of the human CD30 ligand gene structure. (PubMed id 9349718)1, 2, 3, 9 Croager E.J. and Abraham L.J. (1997)
    2. CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. (PubMed id 8391931)1, 2, 3 Smith C.A.... Armitage R.J. (1993)
    3. Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population. (PubMed id 11960307)1, 4, 9 Ahmed S....Hara T. (2002)
    4. Engagement of CD153 (CD30 ligand) by CD30+ T cells inhibits class switch DNA recombination and antibody production in human IgD+ IgM+ B cells. (PubMed id 10878352)1, 9 Cerutti A....Casali P. (2000)
    5. Expression and regulation of CD30 ligand and CD30 in human leukemia-lymphoma cell lines. (PubMed id 7528856)1, 9 Gruss H.J....Drexler H.G. (1994)
    6. CD30L up-regulates CD30 and IL-4 expression by T cells. (PubMed id 11728464)1, 9 Rossi F.M....Gattei V. (2001)
    7. High CD30 ligand expression by epithelial cells and Hassal's corpuscles in the medulla of human thymus. (PubMed id 9558389)1, 9 Romagnani P....Romagnani S. (1998)
    8. Co-expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) in thyroid nodules is associated with co-expression of CD30 ligand/CD30 receptor. (PubMed id 12553555)1, 9 Ruggeri R.M....Benvenga S. (2002)
    9. Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. (PubMed id 16964309)1, 9 Fischer M....Nilsson G. (2006)
    10. A novel role for reciprocal CD30-CD30L signaling in th e cross-talk between natural killer and dendritic cells. (PubMed id 22628304)1 Simhadri V.L....von Strandmann E.P. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 944 HGNC: 11938 AceView: TNFSF8 Ensembl:ENSG00000106952 euGenes: HUgn944
    ECgene: TNFSF8 Kegg: 944 H-InvDB: TNFSF8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFSF8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFSF8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNFSF8 gene:
    Search GeneIP for patents involving TNFSF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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