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TNFSF8 Gene

protein-coding   GIFtS: 58
GCID: GC09M117656

Tumor Necrosis Factor (Ligand) Superfamily, Member 8


(Previous symbol: CD30LG)
  See TNFSF8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor (Ligand) Superfamily, Member 81 2     CD30 Ligand2 3
CD30LG1 2 3 5     CD1532
CD30L2 3 5     CD30 Antigen Ligand2
CD30-L2 3     Tumor Necrosis Factor Ligand Superfamily Member 82
CD153 Antigen2 3     

External Ids:    HGNC: 119381   Entrez Gene: 9442   Ensembl: ENSG000001069527   OMIM: 6038755   UniProtKB: P329713   

Export aliases for TNFSF8 gene to outside databases

Previous GC identifers: GC09M108463 GC09M109397 GC09M111118 GC09M113041 GC09M114744 GC09M116704 GC09M087269


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFSF8 Gene:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This
cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and
related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory
role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell
lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic
biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in
Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for TNFSF8 Gene:
TNFSF8 (tumor necrosis factor (ligand) superfamily, member 8) is a protein-coding gene. Diseases associated with TNFSF8 include spastic diplegia, and hodgkin's lymphoma. GO annotations related to this gene include tumor necrosis factor receptor binding and receptor binding.

UniProtKB/Swiss-Prot: TNFL8_HUMAN, P32971
Function: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFSF8 gene promoter:
         NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFSF8 promoter sequence
   Search Chromatin IP Primers for TNFSF8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFSF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q33

TNFSF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFSF8 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M117656:  view genomic region     (about GC identifiers)

Start:
117,656,003 bp from pter      End:
117,692,770 bp from pter
Size:
36,768 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TNFL8_HUMAN, P32971 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 8  
Size: 234 amino acids; 26017 Da
Subunit: Homotrimer (Probable)
Secondary accessions: O43404

Explore the universe of human proteins at neXtProt for TNFSF8: NX_P32971

Explore proteomics data for TNFSF8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn81, Asn109, Asn153, Asn189, Asn201

  • See TNFSF8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001235.1  NP_001239219.1  

    ENSEMBL proteins: 
     ENSP00000223795  

    TNFSF8 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for TNFSF8
    Sino Biological Cell Lysate for TNFSF8
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TNFSF8 

    TNFSF8 Antibody Products:

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    eBioscience ELISAs for TNFSF8:  
                        Human sCD153 Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFSF: Tumor necrosis factor (ligand) superfamily

    4 InterPro protein domains:
     IPR006052 TNF_dom
     IPR021185 TNF_CD30_ligand_type
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR021184 TNF_CS

    Graphical View of Domain Structure for InterPro Entry P32971

    ProtoNet protein and cluster: P32971

    1 Blocks protein domain: IPB006052 Tumor Necrosis Factor

    UniProtKB/Swiss-Prot: TNFL8_HUMAN, P32971
    Similarity: Belongs to the tumor necrosis factor family


    Find genes that share domains with TNFSF8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNFL8_HUMAN, P32971
    Function: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells

         Genatlas biochemistry entry for TNFSF8:
    tumor necrosis factor (ligand) superfamily,member 8,CD30 ligand on surface of T cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS8391931
    GO:0005125cytokine activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TNFSF8           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tnfsf8):
     immune system 

    Find genes that share phenotypes with TNFSF8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tnfsf8tm1Pod for TNFSF8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFSF8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNFSF8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFSF8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFSF8

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TNFSF8 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TNFSF8:
    hsa-miR-4283 hsa-miR-1237 hsa-miR-1183 hsa-miR-378*
    SwitchGear 3'UTR luciferase reporter plasmidTNFSF8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TNFSF8
    Predesigned siRNA for gene silencing in human, mouse, rat TNFSF8

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TNFSF8 (NM_001244)
    Sino Biological Human cDNA Clone for TNFSF8
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF8

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNFL8_HUMAN, P32971: Membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular3
    cytosol1
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005887integral component of plasma membrane TAS8391931
    GO:0016020membrane ----

    Find genes that share ontologies with TNFSF8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFSF8 About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    4Akt Signaling
    Akt Signaling0.60
    p38 Signaling0.60
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with TNFSF8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFSF8
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFSF8 (see all 16)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Rho Family GTPases
    MIF Mediated Glucocorticoid Regulation

    1 GeneGo (Thomson Reuters) Pathway for TNFSF8
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

    3 Sino Biological Pathways for TNFSF8
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1 Kegg Pathway  (Kegg details for TNFSF8):
        Cytokine-cytokine receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFSF8 (see all 6): 
              TNF Ligands & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFSF8

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TNFSF8 (P329713 ENSP000002237954) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF8P289083, ENSP000002639324I2D: score=2 STRING: ENSP00000263932
    ANGP039503, ENSP000003367624I2D: score=1 STRING: ENSP00000336762
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS8391931
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS8391931
    GO:0007267cell-cell signaling TAS8391931
    GO:0008283cell proliferation TAS8391931

    Find genes that share ontologies with TNFSF8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFSF8 (TNFL8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNFSF8 gene (2 alternative transcripts): 
    NM_001244.3  NM_001252290.1  

    Unigene Cluster for TNFSF8:

    Tumor necrosis factor (ligand) superfamily, member 8
    Hs.494901  [show with all ESTs]
    Unigene Representative Sequence: NM_001244
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474301(uc022bmi.1) ENST00000223795(uc004bji.2)
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate TNFSF8:
    hsa-miR-4283 hsa-miR-1237 hsa-miR-1183 hsa-miR-378*
    SwitchGear 3'UTR luciferase reporter plasmidTNFSF8 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TNFSF8
      QuantiFast Probe-based Assays in human, mouse, rat TNFSF8

    Additional mRNA sequence: 

    AF086214.1 AK313619.1 BC093630.1 BC111939.1 L09753.1 

    4 DOTS entries:

    DT.406506  DT.209534  DT.100644125  DT.40118583 

    Selected AceView cDNA sequences (see all 41):

    BX103824 F02561 AI734260 AF086214 AA287261 CF541382 NM_001244 AI569927 
    BG232102 BG231841 AA748015 BX104360 N95225 L09753 AI936516 AW449271 
    AL583443 AI140118 W02699 AA287260 AI914536 AJ705504 BX462155 BG230605 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFSF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCAGGAAT
    TNFSF8 Expression
    About this image

    TNFSF8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFSF8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.494901
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFSF8 (see all 6): 
              TNF Ligands & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TNFSF8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFSF8 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfsf81 , 5 tumor necrosis factor (ligand) superfamily, member more1, 5 78.83(n)1
    71.67(a)1
      4 (34.06 cM)5
    219491  NM_009403.31  NP_033429.11 
     638313085 
    chicken
    (Gallus gallus)
    Aves TNFSF81 tumor necrosis factor (ligand) superfamily, member more 50.58(n)
    36.84(a)
      378930  NM_204409.1  NP_989740.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNFSF86
    tumor necrosis factor (ligand) superfamily, member...
    32(a)
    1 ↔ 1
    GL343494.1(156362-162978)


    ENSEMBL Gene Tree for TNFSF8 (if available)
    TreeFam Gene Tree for TNFSF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFSF8 (see all 811)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11089831,2
    C,F,H--117655167(-) GATCAT/CGTTTT 1 -- ds500118Minor allele frequency- C:0.21NS EA NA WA CSA 2064
    rs1827043021,2
    --117655209(+) TGGTGA/GATTTG 1 -- ds50010--------
    rs1393492751,2
    --117655223(+) CTGAGA/GCCTTT 1 -- ds50010--------
    rs1432716151,2
    --117655369(+) CTCCCC/TTCTCA 1 -- ds50010--------
    rs1877755401,2
    --117655428(+) CTTTGC/TGGGAA 1 -- ds50010--------
    rs1474602931,2
    --117655463(+) GTGTTG/TTAAGT 1 -- ds50010--------
    rs1931191561,2
    --117655569(+) AACTCC/TGCCAT 1 -- ds50010--------
    rs1845651051,2
    --117655617(+) ATGAAA/TGTGGC 1 -- ds50010--------
    rs104358701,2
    C,F--117655707(+) AGTTCT/AAGACA 1 -- ut311Minor allele frequency- A:0.15NA 120
    rs1161021731,2
    F--117655820(+) ACTTTA/GAAGCA 1 -- ut311Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for TNFSF8 (117656003 - 117692770 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TNFSF8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893750CNV Loss21882294
    nsv6680CNV Loss18451855
    nsv893767CNV Gain21882294
    nsv831695CNV Gain17160897
    nsv7434OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): TNFSF8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFSF8
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFSF8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603875    OMIM disorders: --

    3 diseases for TNFSF8:    
    About MalaCards
    spastic diplegia    hodgkin's lymphoma    takayasu's arteritis

    1 disease from the University of Copenhagen DISEASES database for TNFSF8:
    Lymphoma

    Find genes that share disorders with TNFSF8           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TNFSF8 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 69 10 9209650 (4), 7528856 (1), 8701986 (1), 10908157 (1) (see all 6)
    anaplastic large cell lymphoma 65.5 3 7528856 (1), 8701986 (1), 7527901 (1)
    necrosis 52.9 22 7527901 (2), 8186199 (1), 16547002 (1), 17219720 (1) (see all 17)
    spastic diplegia 52.8 3 9058727 (1), 10512160 (1)
    hypereosinophilic syndrome 52.7 2 8896393 (1)
    lymphocytic leukemia chronic b-cell 52.6 2 16270354 (1), 9058727 (1)
    leukemia hairy cell 45.9 1 9058727 (1)
    lymphoproliferative disorders 41.3 1 9058727 (1)
    tumors 33.7 26 19760074 (2), 9058727 (2), 7527901 (2), 15596049 (2) (see all 17)
    lymphoma non-hodgkins 26.5 2 7528856 (1), 9058727 (1)

    Genetic Association Database (GAD): TNFSF8
    Human Genome Epidemiology (HuGE) Navigator: TNFSF8 (10 documents)

    Export disorders for TNFSF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFSF8 gene, integrated from 10 sources (see all 81):
    (articles sorted by number of sources associating them with TNFSF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterisation of the human CD30 ligand gene structure. (PubMed id 9349718)1, 2, 3, 9 Croager E.J. and Abraham L.J. (Biochim. Biophys. Acta 1997)
    2. CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. (PubMed id 8391931)1, 2, 3 Smith C.A.... Armitage R.J. (Cell 1993)
    3. Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population. (PubMed id 11960307)1, 4, 9 Ahmed S....Hara T. (Genes Immun. 2002)
    4. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    6. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    7. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PubMed id 18636124)1, 4 Skibola C.F....Smith M.T. (PLoS ONE 2008)
    8. Engagement of CD153 (CD30 ligand) by CD30+ T cells inhibits class switch DNA recombination and antibody production in human IgD+ IgM+ B cells. (PubMed id 10878352)1, 9 Cerutti A....Casali P. (J. Immunol. 2000)
    9. Expression and regulation of CD30 ligand and CD30 in human leukemia-lymphoma cell lines. (PubMed id 7528856)1, 9 Gruss H.J....Drexler H.G. (Leukemia 1994)
    10. CD30L up-regulates CD30 and IL-4 expression by T cells. (PubMed id 11728464)1, 9 Rossi F.M....Gattei V. (FEBS Lett. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 944 HGNC: 11938 AceView: TNFSF8 Ensembl:ENSG00000106952 euGenes: HUgn944
    ECgene: TNFSF8 Kegg: 944 H-InvDB: TNFSF8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNFSF8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFSF8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFSF8 gene:
    Search GeneIP for patents involving TNFSF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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