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TNFSF4 Gene

protein-coding   GIFtS: 62
GCID: GC01M173152

Tumor Necrosis Factor (Ligand) Superfamily, Member 4

(Previous names: tax-transcriptionally activated glycoprotein 1, 34kD)
(Previous symbol: TXGP1)
  See TNFSF4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor (Ligand) Superfamily, Member 41 2     CD2522
TXGP11 2 3     OX-40L2
Glycoprotein Gp342 3     CD134 Ligand2
OX40L2 3     OX40 Antigen Ligand2
TAX Transcriptionally-Activated Glycoprotein 12 3     Tax-Transcriptionally Activated Glycoprotein 1 (34kD)2
GP342 5     Tumor Necrosis Factor Ligand Superfamily Member 42
OX4OL2 5     CD252 Antigen3
Tax-Transcriptionally Activated Glycoprotein 1, 34kD1     OX40 Ligand3
CD134L2     

External Ids:    HGNC: 119341   Entrez Gene: 72922   Ensembl: ENSG000001175867   OMIM: 6035945   UniProtKB: P235103   

Export aliases for TNFSF4 gene to outside databases

Previous GC identifers: GC01M170716 GC01M168781 GC01M169733 GC01M170392 GC01M169884 GC01M171419 GC01M144377


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFSF4 Gene:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This
cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC)
interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide
CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate
adhesion of activated T cells to vascular endothelial cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFSF4 Gene:
TNFSF4 (tumor necrosis factor (ligand) superfamily, member 4) is a protein-coding gene. Diseases associated with TNFSF4 include carotid artery disease, and stromal keratitis. GO annotations related to this gene include tumor necrosis factor receptor binding and receptor binding.

UniProtKB/Swiss-Prot: TNFL4_HUMAN, P23510
Function: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFSF4 gene promoter:
         AML1a   AP-1   MEF-2   ATF-2   POU6F1 (c2)   POU3F2   C/EBPalpha   MEF-2A   c-Jun   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFSF4 promoter sequence
   Search Chromatin IP Primers for TNFSF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFSF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q25

TNFSF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFSF4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M173152:  view genomic region     (about GC identifiers)

Start:
173,152,870 bp from pter      End:
173,176,471 bp from pter
Size:
23,602 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TNFL4_HUMAN, P23510 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 4  
Size: 183 amino acids; 21050 Da
Subunit: Homotrimer
Sequence caution: Sequence=CAA18438.2; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for TNFSF4:
2HEV (3D)    
Secondary accessions: Q5JZA5 Q9HCN9

Explore the universe of human proteins at neXtProt for TNFSF4: NX_P23510

Explore proteomics data for TNFSF4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn90, Asn114, Asn152, Asn157
  • Modification sites at PhosphoSitePlus

  • See TNFSF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003317.1  
    ENSEMBL proteins: 
     ENSP00000356691   ENSP00000281834  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFSF: Tumor necrosis factor (ligand) superfamily

    3 InterPro protein domains:
     IPR006052 TNF_dom
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR021184 TNF_CS

    Graphical View of Domain Structure for InterPro Entry P23510

    ProtoNet protein and cluster: P23510

    1 Blocks protein domain: IPB006052 Tumor Necrosis Factor

    UniProtKB/Swiss-Prot: TNFL4_HUMAN, P23510
    Similarity: Belongs to the tumor necrosis factor family


    Find genes that share domains with TNFSF4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNFL4_HUMAN, P23510
    Function: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production
    Induction: By HTLV-1 transactivator p40-Tax

         Genatlas biochemistry entry for TNFSF4:
    tumor necrosis factor (ligand) superfamily,member 4,tax-transcriptionally activated glycoprotein1,human OX-40
    ligand,expressed in T cell infected by HTLV1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS7913952
    GO:0005125cytokine activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding ----
    GO:0032813tumor necrosis factor receptor superfamily binding ISS--
         
    Find genes that share ontologies with TNFSF4           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Tnfsf4):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with TNFSF4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TNFSF4: Tnfsf4tm1Sug Tnfsf4tm1Shr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFSF4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFSF4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFSF4

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TNFSF4 (see all 16):
    hsa-miR-125a-5p hsa-miR-16-2* hsa-miR-188-5p hsa-miR-3921 hsa-miR-877* hsa-miR-125b hsa-miR-3121-3p hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidTNFSF4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TNFSF4
    Predesigned siRNA for gene silencing in human, mouse, rat TNFSF4

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF4

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    ESI BIO PureStem Progenitor for TNFSF4: 
    PureStem Z11, Meso Progenitor
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNFL4_HUMAN, P23510: Membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane4
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA17166734
    GO:0005887integral component of plasma membrane NAS18397322
    GO:0009986cell surface IDA18397322
    GO:0016020membrane ----

    Find genes that share ontologies with TNFSF4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFSF4 About   (see all 9)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    4Akt Signaling
    Akt Signaling0.60
    p38 Signaling0.60
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with TNFSF4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFSF4
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFSF4 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Rho Family GTPases
    MIF Mediated Glucocorticoid Regulation

    1 GeneGo (Thomson Reuters) Pathway for TNFSF4
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    1 BioSystems Pathway for TNFSF4
        TSLP Signaling Pathway

    3 Sino Biological Pathways for TNFSF4
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1 Kegg Pathway  (Kegg details for TNFSF4):
        Cytokine-cytokine receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFSF4 (see all 7): 
              Th1/Th2 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Inflammasomes in human mouse rat
              Common Cytokines in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFSF4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TNFSF4 (P235103 ENSP000002818344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF4P434893, ENSP000003685384I2D: score=2 STRING: ENSP00000368538
    TRAF2Q129333, ENSP000002476684I2D: score=1 STRING: ENSP00000247668
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 51):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001816cytokine production ----
    GO:0002215defense response to nematode ISS--
    GO:0002526acute inflammatory response ISS--
    GO:0002726positive regulation of T cell cytokine production ISS--
    GO:0002819regulation of adaptive immune response ISS--

    Find genes that share ontologies with TNFSF4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFSF4 (TNFL4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNFSF4 gene: 
    NM_003326.3  

    Unigene Cluster for TNFSF4:

    Tumor necrosis factor (ligand) superfamily, member 4
    Hs.181097  [show with all ESTs]
    Unigene Representative Sequence: NM_003326
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367718(uc001giv.3) ENST00000281834(uc001giw.3) ENST00000488053

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    Selected qRT-PCR Assays for microRNAs that regulate TNFSF4 (see all 16):
    hsa-miR-125a-5p hsa-miR-16-2* hsa-miR-188-5p hsa-miR-3921 hsa-miR-877* hsa-miR-125b hsa-miR-3121-3p hsa-miR-556-3p
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    Additional mRNA sequence: 

    AK297932.1 BC041663.1 CR542033.1 D90224.1 X79929.1 

    4 DOTS entries:

    DT.91757788  DT.452353  DT.100736968  DT.440139 

    Selected AceView cDNA sequences (see all 86):

    CF127212 AI018755 BE670575 BE220598 BE349175 BG389239 BQ420934 BM725742 
    BX345040 AA806822 BI062717 AW304750 BC041663 BX117627 CA443992 BX389365 
    X79929 NM_003326 BU740598 BE894809 BQ688518 AA382361 BM712491 BE672349 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFSF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGCCTCTG
    TNFSF4 Expression
    About this image


    TNFSF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    TNFSF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFSF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.181097
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFSF4 (see all 7): 
              Th1/Th2 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Inflammasomes in human mouse rat
              Common Cytokines in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TNFSF4 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfsf41 , 5 tumor necrosis factor (ligand) superfamily, member more1, 5 68.54(n)1
    46.07(a)1
      1 (69.75 cM)5
    221641  NM_009452.21  NP_033478.11 
     1613954095 


    ENSEMBL Gene Tree for TNFSF4 (if available)
    TreeFam Gene Tree for TNFSF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFSF4 (see all 501)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs595978941,2
    C--173152377(+) GAGAA-/AGAGAA
            
    GTCCA
    1 -- cds10--------
    rs454882921,2
    C--173154004(-) ACTCACA/-GAATC 1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs616491211,2
    C--173165574(+) TCTCT-/CTTAACC 1 -- int10--------
    rs1998271811,2
    C--173171198(+) ATATA-/AT/TA 
            
    CACAC
    1 -- int10--------
    rs57787491,2
    C--173172424(+) gccccC/-aaatt 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs106445151,2
    C--179705228(+) AGAACAGAAAG/-
            
    AGAAA
    1 -- cds11Minor allele frequency- -:0.50CSA 2
    rs1129862141,2
    --179705228(+) GAGAAG/CAGAAA 1 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs1809374821,2
    --179705259(+) AGGTCA/CAAAAA 1 -- ds50010--------
    rs168455341,2
    C,F--179705365(+) ATTAAT/CAGTTG 1 -- ds50014Minor allele frequency- C:0.07NA WA 256
    rs759158091,2
    C,F--179705648(+) CCCGTC/TCTCCC 1 -- ds50011Minor allele frequency- T:0.05WA 118

    HapMap Linkage Disequilibrium report for TNFSF4 (173152870 - 173176471 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TNFSF4: --
    Human Gene Mutation Database (HGMD): TNFSF4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFSF4
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFSF4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 603594   
    OMIM disorders: 608446  
    UniProtKB/Swiss-Prot: TNFL4_HUMAN, P23510
  • Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile
    multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints,
    kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory
    mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated
    erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry. The upstream region of
    TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both
    cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC
    interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance

  • 7 diseases for TNFSF4:    
    About MalaCards
    carotid artery disease    stromal keratitis    narcolepsy 1    takayasu's arteritis
    keratitis    myocardial infarction    narcolepsy

    1 disease from the University of Copenhagen DISEASES database for TNFSF4:
    Systemic lupus erythematosus

    Find genes that share disorders with TNFSF4           About GenesLikeMe

    6 Novoseek inferred disease relationships for TNFSF4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 55.9 5 9603911 (2), 1996093 (2), 9108415 (1)
    necrosis 55 30 16547002 (1), 18998106 (1), 9603911 (1), 18674525 (1) (see all 15)
    lupus erythematosus systemic 35.8 9 19092840 (2), 10906156 (1), 19083191 (1), 19778912 (1)
    tumors 35 27 16547002 (1), 18998106 (1), 9603911 (1), 18674525 (1) (see all 14)
    vasculitis 9.3 2 16443547 (1), 10906156 (1)
    leukemia 0 3 17618572 (2)

    Genetic Association Database (GAD): TNFSF4
    Human Genome Epidemiology (HuGE) Navigator: TNFSF4 (36 documents)

    Export disorders for TNFSF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFSF4 gene, integrated from 10 sources (see all 151):
    (articles sorted by number of sources associating them with TNFSF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax. (PubMed id 1996093)1, 2, 3, 9 Miura S.... Sugamura K. (Mol. Cell. Biol. 1991)
    2. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. (PubMed id 8076595)1, 2, 3, 9 Baum P.R.... Fanslow W.C. (EMBO J. 1994)
    3. New variations in human OX40 ligand (CD134L) gene. (PubMed id 11197696)1, 2, 4, 9 Hikami K.... Tokunaga K. (Genes Immun. 2000)
    4. Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. (PubMed id 18059267)1, 2, 4 Cunninghame Graham D.S.... Vyse T.J. (Nat. Genet. 2008)
    5. Genetic variants of TNFSF4 and risk for carotid artery disease and stroke. (PubMed id 18998106)1, 4, 9 Olofsson P.S....Hansson G.K. (J. Mol. Med. 2009)
    6. Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis. (PubMed id 19778912)1, 4, 9 Gourh P....Agarwal S.K. (Ann. Rheum. Dis. 2010)
    7. Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus. (PubMed id 19092840)1, 4, 9 Delgado-Vega A.M....AlarcA^n-Riquelme M.E. (Genes Immun. 2009)
    8. Association of TNFRSF4 gene polymorphisms with essential hypertension. (PubMed id 18398332)1, 4, 9 Mashimo Y....Hata A. (J. Hypertens. 2008)
    9. A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han population. (PubMed id 20012871)1, 4 Zhang S.Q....Yang S. (Rheumatol. Int. 2011)
    10. Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients. (PubMed id 20881011)1, 4 Webb R....Sawalha A.H. (Ann. Rheum. Dis. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 7292 HGNC: 11934 AceView: TNFSF4 Ensembl:ENSG00000117586 euGenes: HUgn7292
    ECgene: TNFSF4 Kegg: 7292 H-InvDB: TNFSF4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TNFSF4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFSF4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TNFSF4 gene:
    Search GeneIP for patents involving TNFSF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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