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Aliases for TNFSF4 Gene

Aliases for TNFSF4 Gene

  • Tumor Necrosis Factor (Ligand) Superfamily, Member 4 2 3
  • Glycoprotein Gp34 3 4
  • TXGP1 3 4
  • OX4OL 3 6
  • GP34 3 6
  • Tax-Transcriptionally Activated Glycoprotein 1 (34kD) 3
  • Tax-Transcriptionally Activated Glycoprotein 1, 34kD 2
  • Tumor Necrosis Factor Ligand Superfamily Member 4 3
  • TAX Transcriptionally-Activated Glycoprotein 1 4
  • OX40 Antigen Ligand 3
  • CD252 Antigen 4
  • CD134 Ligand 3
  • OX40 Ligand 4
  • CD134L 3
  • OX-40L 3
  • CD252 3
  • OX40L 4

External Ids for TNFSF4 Gene

Previous HGNC Symbols for TNFSF4 Gene

  • TXGP1

Previous GeneCards Identifiers for TNFSF4 Gene

  • GC01M170716
  • GC01M168781
  • GC01M169733
  • GC01M170392
  • GC01M169884
  • GC01M171419
  • GC01M144377

Summaries for TNFSF4 Gene

Entrez Gene Summary for TNFSF4 Gene

  • This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for TNFSF4 Gene

TNFSF4 (Tumor Necrosis Factor (Ligand) Superfamily, Member 4) is a Protein Coding gene. Diseases associated with TNFSF4 include carotid artery disease and stromal keratitis. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding.

UniProtKB/Swiss-Prot for TNFSF4 Gene

  • Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF4 Gene

Genomics for TNFSF4 Gene

Regulatory Elements for TNFSF4 Gene

Genomic Location for TNFSF4 Gene

173,183,731 bp from pter
173,207,332 bp from pter
23,602 bases
Minus strand

Genomic View for TNFSF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFSF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF4 Gene

Proteins for TNFSF4 Gene

  • Protein details for TNFSF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor ligand superfamily member 4
    Protein Accession:
    Secondary Accessions:
    • Q5JZA5
    • Q8IV74
    • Q9HCN9

    Protein attributes for TNFSF4 Gene

    183 amino acids
    Molecular mass:
    21050 Da
    Quaternary structure:
    • Homotrimer.
    • Sequence=CAA18438.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNFSF4 Gene

    Alternative splice isoforms for TNFSF4 Gene


neXtProt entry for TNFSF4 Gene

Proteomics data for TNFSF4 Gene at MOPED

Post-translational modifications for TNFSF4 Gene

  • Glycosylation at Asn90, Asn114, Asn152, and Asn157
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFSF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFSF4 (OX40 Ligand/TNFSF4)
  • Cell Signaling Technology (CST) Antibodies for TNFSF4 (TNFSF4)

No data available for DME Specific Peptides for TNFSF4 Gene

Domains for TNFSF4 Gene

Protein Domains for TNFSF4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tumor necrosis factor family.
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF4: view

Function for TNFSF4 Gene

Molecular function for TNFSF4 Gene

GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 4,tax-transcriptionally activated glycoprotein1,human OX-40 ligand,expressed in T cell infected by HTLV1
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production
UniProtKB/Swiss-Prot Induction:
By HTLV-1 transactivator p40-Tax

Gene Ontology (GO) - Molecular Function for TNFSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 7913952
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding --
GO:0032813 tumor necrosis factor receptor superfamily binding ISS --
genes like me logo Genes that share ontologies with TNFSF4: view
genes like me logo Genes that share phenotypes with TNFSF4: view

Animal Models for TNFSF4 Gene

MGI Knock Outs for TNFSF4:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for TNFSF4 Gene

Localization for TNFSF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for TNFSF4 Gene COMPARTMENTS Subcellular localization image for TNFSF4 gene
Compartment Confidence
extracellular 4
plasma membrane 4
cytosol 3

Gene Ontology (GO) - Cellular Components for TNFSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 17166734
GO:0005887 integral component of plasma membrane NAS 18397322
GO:0009986 cell surface IDA 18397322
GO:0016020 membrane --
genes like me logo Genes that share ontologies with TNFSF4: view

Pathways for TNFSF4 Gene

genes like me logo Genes that share pathways with TNFSF4: view

Pathways by source for TNFSF4 Gene

3 Sino Biological pathways for TNFSF4 Gene
1 BioSystems pathway for TNFSF4 Gene
1 KEGG pathway for TNFSF4 Gene
1 GeneGo (Thomson Reuters) pathway for TNFSF4 Gene

PCR Array Products

Interacting Proteins for TNFSF4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000281834 P23510-TNFL4_HUMAN for TNFSF4 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TNFSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production --
GO:0002215 defense response to nematode ISS --
GO:0002526 acute inflammatory response ISS --
GO:0002726 positive regulation of T cell cytokine production ISS --
GO:0002819 regulation of adaptive immune response ISS --
genes like me logo Genes that share ontologies with TNFSF4: view

Transcripts for TNFSF4 Gene

Unigene Clusters for TNFSF4 Gene

Tumor necrosis factor (ligand) superfamily, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFSF4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF4 Gene

No ASD Table

Relevant External Links for TNFSF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFSF4 Gene

mRNA expression in normal human tissues for TNFSF4 Gene

SOURCE GeneReport for Unigene cluster for TNFSF4 Gene Hs.181097

genes like me logo Genes that share expressions with TNFSF4: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TNFSF4 Gene

Orthologs for TNFSF4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TNFSF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNFSF4 35
  • 81.4 (n)
  • 69.61 (a)
  • 69 (a)
(Canis familiaris)
Mammalia TNFSF4 35
  • 81.68 (n)
  • 68.13 (a)
  • 68 (a)
(Mus musculus)
Mammalia Tnfsf4 35
  • 68.54 (n)
  • 46.07 (a)
Tnfsf4 16
Tnfsf4 36
  • 41 (a)
(Pan troglodytes)
Mammalia TNFSF4 35
  • 99.64 (n)
  • 99.45 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tnfsf4 35
  • 69.65 (n)
  • 47.49 (a)
(Monodelphis domestica)
Mammalia TNFSF4 36
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia TNFSF4 36
  • 35 (a)
Species with no ortholog for TNFSF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF4 Gene

Gene Tree for TNFSF4 (if available)
Gene Tree for TNFSF4 (if available)

Paralogs for TNFSF4 Gene

No data available for Paralogs for TNFSF4 Gene

Variants for TNFSF4 Gene

Sequence variations from dbSNP and Humsavar for TNFSF4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1234313 -- 173,197,108(+) TATAC(A/G)TTGCT intron-variant
rs1234314 -- 173,208,253(+) ATGAG(C/G)CTGGC upstream-variant-2KB
rs1234315 -- 173,209,324(+) CATCA(C/T)TGGGC upstream-variant-2KB
rs3850641 -- 173,206,693(+) TCACA(A/G)TGGGT upstream-variant-2KB, intron-variant
rs3861949 -- 173,184,047(+) GAGAA(A/G)GTTAC utr-variant-3-prime

Relevant External Links for TNFSF4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TNFSF4 Gene

Disorders for TNFSF4 Gene

(1) OMIM Diseases for TNFSF4 Gene (603594)


  • Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:18059267}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance.

(1) University of Copenhagen DISEASES for TNFSF4 Gene

(6) Novoseek inferred disease relationships for TNFSF4 Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 55.9 5
necrosis 55 15
lupus erythematosus systemic 35.8 5
tumors 35 14
vasculitis 9.3 2

Relevant External Links for TNFSF4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TNFSF4: view

No data available for Genatlas for TNFSF4 Gene

Publications for TNFSF4 Gene

  1. New variations in human OX40 ligand (CD134L) gene. (PMID: 11197696) Hikami K. … Tokunaga K. (Genes Immun. 2000) 3 4 23 48
  2. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. (PMID: 8076595) Baum P.R. … Fanslow W.C. (EMBO J. 1994) 2 3 4 23
  3. Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax. (PMID: 1996093) Miura S. … Sugamura K. (Mol. Cell. Biol. 1991) 2 3 4 23
  4. Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis. (PMID: 19778912) Gourh P. … Agarwal S.K. (Ann. Rheum. Dis. 2010) 3 23 48
  5. Genetic variants of TNFSF4 and risk for carotid artery disease and stroke. (PMID: 18998106) Olofsson P.S. … Hansson G.K. (J. Mol. Med. 2009) 3 23 48

Products for TNFSF4 Gene

Sources for TNFSF4 Gene

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