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Aliases for TNFSF4 Gene

Aliases for TNFSF4 Gene

  • TNF Superfamily Member 4 2 3
  • Tumor Necrosis Factor Superfamily Member 4 3 5
  • Glycoprotein Gp34 3 4
  • TXGP1 3 4
  • Tax-Transcriptionally Activated Glycoprotein 1 (34kD) 3
  • Tax-Transcriptionally Activated Glycoprotein 1, 34kD 2
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 4 2
  • Tumor Necrosis Factor (Ligand) Superfamily Member 4 3
  • Tumor Necrosis Factor Ligand Superfamily Member 4 3
  • TAX Transcriptionally-Activated Glycoprotein 1 4
  • Tumor Necrosis Factor Ligand 2B 3
  • OX40 Antigen Ligand 3
  • CD252 Antigen 4
  • CD134 Ligand 3
  • OX40 Ligand 4
  • CD134L 3
  • OX-40L 3
  • TNLG2B 3
  • CD252 3
  • OX4OL 3
  • OX40L 4
  • GP34 3

External Ids for TNFSF4 Gene

Previous HGNC Symbols for TNFSF4 Gene

  • TXGP1

Previous GeneCards Identifiers for TNFSF4 Gene

  • GC01M170716
  • GC01M168781
  • GC01M169733
  • GC01M170392
  • GC01M169884
  • GC01M171419
  • GC01M144377

Summaries for TNFSF4 Gene

Entrez Gene Summary for TNFSF4 Gene

  • This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for TNFSF4 Gene

TNFSF4 (TNF Superfamily Member 4) is a Protein Coding gene. Diseases associated with TNFSF4 include Myocardial Infarction and Sjogren's Syndrome. Among its related pathways are TRAF Pathway and Th2 Differentiation Pathway. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding.

UniProtKB/Swiss-Prot for TNFSF4 Gene

  • Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF4 Gene

Genomics for TNFSF4 Gene

Regulatory Elements for TNFSF4 Gene

Enhancers for TNFSF4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G172892 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +311.8 311803 7.3 PKNOX1 FEZF1 RAD21 BRCA1 GATA2 EGR1 SCRT2 RCOR1 FOS CEBPB FASLG TNFSF4 ENSG00000224228 SUCO AIMP1P2 ENSG00000224000
GH01G172845 1 FANTOM5 Ensembl 13.4 +362.5 362472 0.4 ATF1 CBX3 NR2F1 EBF1 ZBTB7B FOSL1 JUND ZNF316 ZNF585B EGR1 ENSG00000224228 TNFSF4 LOC105371618 AIMP1P2
GH01G172754 0.4 FANTOM5 12.6 +453.9 453862 0.4 JUND TNFSF4 ENSG00000279061 ENSG00000224228
GH01G172931 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.2 +273.9 273909 5.3 PKNOX1 ARNT SIN3A ZNF766 FOS JUNB ZNF592 MEF2D SMARCA4 GLIS1 ENSG00000224228 TNFSF18 TNFSF4 ENSG00000224000
GH01G173409 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.2 -202.3 -202328 2.6 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 SIN3A EGR1 GATA2 ZNF143 RELB KLHL20 CENPL DARS2 PRDX6 ENSG00000224228 TNFSF4 GC01M173428 LOC646870
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFSF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNFSF4 Gene

173,183,731 bp from pter
173,208,072 bp from pter
24,342 bases
Minus strand

Genomic View for TNFSF4 Gene

Genes around TNFSF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF4 Gene

Proteins for TNFSF4 Gene

  • Protein details for TNFSF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor ligand superfamily member 4
    Protein Accession:
    Secondary Accessions:
    • Q5JZA5
    • Q8IV74
    • Q9HCN9

    Protein attributes for TNFSF4 Gene

    183 amino acids
    Molecular mass:
    21050 Da
    Quaternary structure:
    • Homotrimer.
    • Sequence=CAA18438.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNFSF4 Gene

    Alternative splice isoforms for TNFSF4 Gene


neXtProt entry for TNFSF4 Gene

Post-translational modifications for TNFSF4 Gene

  • Glycosylation at posLast=9090, Asn114, isoforms=2152, and Asn157
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFSF4 Gene

Antibody Products

  • R&D Systems Antibodies for TNFSF4 (OX40 Ligand/TNFSF4)
  • Cell Signaling Technology (CST) Antibodies for TNFSF4 (TNFSF4)
  • Abcam antibodies for TNFSF4

Protein Products

  • Abcam proteins for TNFSF4

Assay Products

  • Cloud-Clone Corp. Assay Kits for TNFSF4
  • Abcam assays for TNFSF4

No data available for DME Specific Peptides for TNFSF4 Gene

Domains & Families for TNFSF4 Gene

Gene Families for TNFSF4 Gene

Protein Domains for TNFSF4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tumor necrosis factor family.
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF4: view

Function for TNFSF4 Gene

Molecular function for TNFSF4 Gene

GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 4,tax-transcriptionally activated glycoprotein1,human OX-40 ligand,expressed in T cell infected by HTLV1
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
UniProtKB/Swiss-Prot Induction:
By HTLV-1 transactivator p40-Tax.

Gene Ontology (GO) - Molecular Function for TNFSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 7913952
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0032813 tumor necrosis factor receptor superfamily binding ISS,IBA --
genes like me logo Genes that share ontologies with TNFSF4: view
genes like me logo Genes that share phenotypes with TNFSF4: view

Human Phenotype Ontology for TNFSF4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TNFSF4 Gene

MGI Knock Outs for TNFSF4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for TNFSF4 (OX40 Ligand/TNFSF4)

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNFSF4 Gene

Localization for TNFSF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 4

Gene Ontology (GO) - Cellular Components for TNFSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 17166734
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,NAS 18397322
GO:0009986 cell surface IDA 18397322
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFSF4: view

Pathways & Interactions for TNFSF4 Gene

genes like me logo Genes that share pathways with TNFSF4: view

Interacting Proteins for TNFSF4 Gene

SIGNOR curated interactions for TNFSF4 Gene


Gene Ontology (GO) - Biological Process for TNFSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002215 defense response to nematode ISS --
GO:0002526 acute inflammatory response ISS --
GO:0002726 positive regulation of T cell cytokine production ISS --
GO:0002819 regulation of adaptive immune response ISS --
GO:0002830 positive regulation of type 2 immune response ISS --
genes like me logo Genes that share ontologies with TNFSF4: view

Drugs & Compounds for TNFSF4 Gene

No Compound Related Data Available

Transcripts for TNFSF4 Gene

Unigene Clusters for TNFSF4 Gene

Tumor necrosis factor (ligand) superfamily, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for TNFSF4 (OX40 Ligand/TNFSF4)

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF4 Gene

No ASD Table

Relevant External Links for TNFSF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFSF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFSF4 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFSF4 Gene:


SOURCE GeneReport for Unigene cluster for TNFSF4 Gene:


Evidence on tissue expression from TISSUES for TNFSF4 Gene

  • Heart(3)
  • Intestine(3)
  • Liver(2.8)
  • Stomach(2.8)
  • Lymph node(2.7)
  • Muscle(2.6)
  • Spleen(2.6)
  • Blood(2.5)
  • Nervous system(2.5)
  • Kidney(2.2)
  • Skin(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF4 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • nervous
  • respiratory
  • skeletal muscle
Head and neck:
  • brain
  • cranial nerve
  • ear
  • eye
  • head
  • mouth
  • pharynx
  • heart
  • blood vessel
  • peripheral nervous system
genes like me logo Genes that share expression patterns with TNFSF4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TNFSF4 Gene

Orthologs for TNFSF4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TNFSF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFSF4 34 35
  • 99.64 (n)
(Canis familiaris)
Mammalia TNFSF4 34 35
  • 81.68 (n)
(Bos Taurus)
Mammalia TNFSF4 34 35
  • 81.4 (n)
(Rattus norvegicus)
Mammalia Tnfsf4 34
  • 69.65 (n)
(Mus musculus)
Mammalia Tnfsf4 34 16 35
  • 68.54 (n)
(Monodelphis domestica)
Mammalia TNFSF4 35
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia TNFSF4 35
  • 35 (a)
Species where no ortholog for TNFSF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF4 Gene

Gene Tree for TNFSF4 (if available)
Gene Tree for TNFSF4 (if available)

Paralogs for TNFSF4 Gene

No data available for Paralogs for TNFSF4 Gene

Variants for TNFSF4 Gene

Sequence variations from dbSNP and Humsavar for TNFSF4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000004849 -- 173,305,067(+) AATTT(C/T)TCAGA intron-variant
rs1000012315 -- 173,246,786(+) CCTCT(A/C)TTCCT intron-variant
rs1000023583 -- 173,443,049(+) AGTGA(A/G)CCTTG intron-variant, nc-transcript-variant, utr-variant-5-prime
rs1000038766 -- 173,357,247(+) GAAAG(C/T)AGATT intron-variant
rs1000049540 -- 173,271,060(+) GAACT(A/G)AGATT intron-variant

Variation tolerance for TNFSF4 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFSF4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TNFSF4 Gene

Disorders for TNFSF4 Gene

MalaCards: The human disease database

(8) MalaCards diseases for TNFSF4 Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, protection against
sjogren's syndrome
  • sicca syndrome
  • narcolepsy, without cataplexy
stromal keratitis
chronic conjunctivitis
  • chronic conjunctivitis nos
- elite association - COSMIC cancer census association via MalaCards


  • Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:18059267}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance.

Relevant External Links for TNFSF4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TNFSF4: view

No data available for Genatlas for TNFSF4 Gene

Publications for TNFSF4 Gene

  1. New variations in human OX40 ligand (CD134L) gene. (PMID: 11197696) Hikami K. … Tokunaga K. (Genes Immun. 2000) 3 4 22 46 64
  2. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. (PMID: 8076595) Baum P.R. … Fanslow W.C. (EMBO J. 1994) 2 3 4 22 64
  3. Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax. (PMID: 1996093) Miura S. … Sugamura K. (Mol. Cell. Biol. 1991) 2 3 4 22 64
  4. Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis. (PMID: 19778912) Gourh P. … Agarwal S.K. (Ann. Rheum. Dis. 2010) 3 22 46 64
  5. Genetic variants of TNFSF4 and risk for carotid artery disease and stroke. (PMID: 18998106) Olofsson P.S. … Hansson G.K. (J. Mol. Med. 2009) 3 22 46 64

Products for TNFSF4 Gene

Sources for TNFSF4 Gene

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