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Aliases for TNFSF4 Gene

Aliases for TNFSF4 Gene

  • Tumor Necrosis Factor Superfamily Member 4 2 3 5
  • Glycoprotein Gp34 3 4
  • TXGP1 3 4
  • Tax-Transcriptionally Activated Glycoprotein 1 (34kD) 3
  • Tax-Transcriptionally Activated Glycoprotein 1, 34kD 2
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 4 2
  • Tumor Necrosis Factor (Ligand) Superfamily Member 4 3
  • TAX Transcriptionally-Activated Glycoprotein 1 4
  • Tumor Necrosis Factor Ligand 2B 3
  • OX40 Antigen Ligand 3
  • CD252 Antigen 4
  • CD134 Ligand 3
  • OX40 Ligand 4
  • CD134L 3
  • OX-40L 3
  • TNLG2B 3
  • CD252 3
  • OX4OL 3
  • OX40L 4
  • GP34 3

External Ids for TNFSF4 Gene

Previous HGNC Symbols for TNFSF4 Gene

  • TXGP1

Previous GeneCards Identifiers for TNFSF4 Gene

  • GC01M170716
  • GC01M168781
  • GC01M169733
  • GC01M170392
  • GC01M169884
  • GC01M171419
  • GC01M144377

Summaries for TNFSF4 Gene

Entrez Gene Summary for TNFSF4 Gene

  • This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for TNFSF4 Gene

TNFSF4 (Tumor Necrosis Factor Superfamily Member 4) is a Protein Coding gene. Diseases associated with TNFSF4 include myocardial infarction and narcolepsy. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding.

UniProtKB/Swiss-Prot for TNFSF4 Gene

  • Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF4 Gene

Genomics for TNFSF4 Gene

Regulatory Elements for TNFSF4 Gene

Genomic Location for TNFSF4 Gene

Chromosome:
1
Start:
173,183,731 bp from pter
End:
173,208,072 bp from pter
Size:
24,342 bases
Orientation:
Minus strand

Genomic View for TNFSF4 Gene

Genes around TNFSF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF4 Gene

Proteins for TNFSF4 Gene

  • Protein details for TNFSF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23510-TNFL4_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 4
    Protein Accession:
    P23510
    Secondary Accessions:
    • Q5JZA5
    • Q8IV74
    • Q9HCN9

    Protein attributes for TNFSF4 Gene

    Size:
    183 amino acids
    Molecular mass:
    21050 Da
    Quaternary structure:
    • Homotrimer.
    SequenceCaution:
    • Sequence=CAA18438.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNFSF4 Gene

    Alternative splice isoforms for TNFSF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFSF4 Gene

Proteomics data for TNFSF4 Gene at MOPED

Post-translational modifications for TNFSF4 Gene

  • Glycosylation at Asn 90, Asn 114, Asn 152, and Asn 157
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFSF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFSF4 (OX40 Ligand/TNFSF4)
  • Cell Signaling Technology (CST) Antibodies for TNFSF4 (TNFSF4)

No data available for DME Specific Peptides for TNFSF4 Gene

Domains & Families for TNFSF4 Gene

Gene Families for TNFSF4 Gene

Protein Domains for TNFSF4 Gene

Graphical View of Domain Structure for InterPro Entry

P23510

UniProtKB/Swiss-Prot:

TNFL4_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF4: view

Function for TNFSF4 Gene

Molecular function for TNFSF4 Gene

GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 4,tax-transcriptionally activated glycoprotein1,human OX-40 ligand,expressed in T cell infected by HTLV1
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
UniProtKB/Swiss-Prot Induction:
By HTLV-1 transactivator p40-Tax.
genes like me logo Genes that share phenotypes with TNFSF4: view

Human Phenotype Ontology for TNFSF4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TNFSF4 Gene

MGI Knock Outs for TNFSF4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Cell Line Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for TNFSF4 Gene

Localization for TNFSF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFSF4 Gene COMPARTMENTS Subcellular localization image for TNFSF4 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 4
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for TNFSF4 Gene

Pathways & Interactions for TNFSF4 Gene

genes like me logo Genes that share pathways with TNFSF4: view

Interacting Proteins for TNFSF4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000281834%0d%0a9606.ENSP00000368538%0d%0a9606.ENSP00000247668%0d%0a
Selected Interacting proteins: ENSP00000281834 P23510-TNFL4_HUMAN for TNFSF4 Gene via STRING I2D

SIGNOR curated interactions for TNFSF4 Gene

Activates:

Gene Ontology (GO) - Biological Process for TNFSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002215 defense response to nematode IEA,ISS --
GO:0002526 acute inflammatory response IEA,ISS --
GO:0002726 positive regulation of T cell cytokine production IEA,ISS --
GO:0002830 positive regulation of type 2 immune response IEA,ISS --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with TNFSF4: view

Drugs & Compounds for TNFSF4 Gene

No Compound Related Data Available

Transcripts for TNFSF4 Gene

Unigene Clusters for TNFSF4 Gene

Tumor necrosis factor (ligand) superfamily, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF4 Gene

No ASD Table

Relevant External Links for TNFSF4 Gene

GeneLoc Exon Structure for
TNFSF4
ECgene alternative splicing isoforms for
TNFSF4

Expression for TNFSF4 Gene

mRNA expression in normal human tissues for TNFSF4 Gene

SOURCE GeneReport for Unigene cluster for TNFSF4 Gene Hs.181097

genes like me logo Genes that share expression patterns with TNFSF4: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TNFSF4 Gene

Orthologs for TNFSF4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TNFSF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFSF4 35
  • 99.64 (n)
  • 99.45 (a)
TNFSF4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNFSF4 36
  • 69 (a)
OneToOne
TNFSF4 35
  • 81.4 (n)
  • 69.61 (a)
dog
(Canis familiaris)
Mammalia TNFSF4 35
  • 81.68 (n)
  • 68.13 (a)
TNFSF4 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnfsf4 36
  • 41 (a)
OneToOne
Tnfsf4 16
Tnfsf4 35
  • 68.54 (n)
  • 46.07 (a)
oppossum
(Monodelphis domestica)
Mammalia TNFSF4 36
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFSF4 36
  • 35 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfsf4 35
  • 69.65 (n)
  • 47.49 (a)
Species with no ortholog for TNFSF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF4 Gene

ENSEMBL:
Gene Tree for TNFSF4 (if available)
TreeFam:
Gene Tree for TNFSF4 (if available)

Paralogs for TNFSF4 Gene

No data available for Paralogs for TNFSF4 Gene

Variants for TNFSF4 Gene

Sequence variations from dbSNP and Humsavar for TNFSF4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1234313 -- 173,197,108(+) TATAC(A/G)TTGCT intron-variant
rs1234315 -- 173,209,324(+) CATCA(C/T)TGGGC upstream-variant-2KB
rs3850641 -- 173,206,693(+) TCACA(A/G)TGGGT intron-variant, upstream-variant-2KB
rs4081545 -- 173,190,377(+) TTCCA(C/T)TGGCA intron-variant
rs4113832 -- 173,190,481(+) AGAGT(C/T)ATTCT intron-variant

Variation tolerance for TNFSF4 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFSF4 Gene

HapMap Linkage Disequilibrium report
TNFSF4
Human Gene Mutation Database (HGMD)
TNFSF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TNFSF4 Gene

Disorders for TNFSF4 Gene

MalaCards: The human disease database

(8) MalaCards diseases for TNFSF4 Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, protection against
narcolepsy
  • narcolepsy, without cataplexy
sjogren's syndrome
  • sicca syndrome
systemic lupus erythematosus
  • lupus nephritis
lupus erythematosus
  • lupus
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TNFL4_HUMAN
  • Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:18059267}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance.

Relevant External Links for TNFSF4

Genetic Association Database (GAD)
TNFSF4
Human Genome Epidemiology (HuGE) Navigator
TNFSF4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFSF4
genes like me logo Genes that share disorders with TNFSF4: view

No data available for Genatlas for TNFSF4 Gene

Publications for TNFSF4 Gene

  1. Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax. (PMID: 1996093) Miura S. … Sugamura K. (Mol. Cell. Biol. 1991) 2 3 4 23 67
  2. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. (PMID: 8076595) Baum P.R. … Fanslow W.C. (EMBO J. 1994) 2 3 23
  3. Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis. (PMID: 19778912) Gourh P. … Agarwal S.K. (Ann. Rheum. Dis. 2010) 3 23
  4. Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells. (PMID: 19029446) Krause P. … Legler D.F. (Blood 2009) 3 23
  5. Genetic variants of TNFSF4 and risk for carotid artery disease and stroke. (PMID: 18998106) Olofsson P.S. … Hansson G.K. (J. Mol. Med. 2009) 3 23

Products for TNFSF4 Gene

Sources for TNFSF4 Gene

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