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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFSF4 Gene

protein-coding   GIFtS: 63
GCID: GC01M173152

tumor necrosis factor (ligand) superfamily, member 4

(Previous names: tax-transcriptionally activated glycoprotein 1, 34kD )
(Previous symbol: TXGP1)
 Explore 47 diseases affiliated with
TNFSF4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TNFSF4    

Aliases
for TNFSF4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Necrosis Factor (Ligand) Superfamily, Member 41 2     Gp341
TXGP11 2 3     Tax-Transcriptionally Activated Glycoprotein 1, 34kD1
CD2521 2     CD134L2
OX-40L1 2     CD134 Ligand2
Glycoprotein Gp342 3     OX40 Antigen Ligand2
OX40L2 3     Tax-Transcriptionally Activated Glycoprotein 1 (34kD)2
TAX Transcriptionally-Activated Glycoprotein 12 3     Tumor Necrosis Factor Ligand Superfamily Member 42
GP342 5     CD252 Antigen3
OX4OL2 5     OX40 Ligand3

External Ids:    HGNC: 119341   Entrez Gene: 72922   Ensembl: ENSG000001175867   OMIM: 6035945   UniProtKB: P235103   

Export aliases for TNFSF4 gene to outside databases

Previous GC identifers: GC01M170716 GC01M168781 GC01M169733 GC01M170392 GC01M169884 GC01M171419 GC01M144377


Summaries
for TNFSF4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TNFSF4:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This
cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC)
interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide
CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate
adhesion of activated T cells to vascular endothelial cells. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNFL4_HUMAN, P23510
Function: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production




Genomic Views
for TNFSF4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFSF4 gene promoter:
         AML1a   AP-1   MEF-2   ATF-2   POU6F1 (c2)   POU3F2   C/EBPalpha   MEF-2A   c-Jun   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFSF4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFSF4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFSF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q25

TNFSF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFSF4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M173152:  view genomic region     (about GC identifiers)

Start:
 173,152,870 bp from pter      End:
 173,176,471 bp from pter
Size:
 23,602 bases      Orientation:
 minus strand

Proteins
for TNFSF4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TNFL4_HUMAN, P23510 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 4  
Size: 183 amino acids; 21050 Da
Subunit: Homotrimer
Subcellular location: Membrane; Single-pass type II membrane protein
Sequence caution: Sequence=CAA18438.2; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for TNFSF4:
2HEV (3D)    
Secondary accessions: Q5JZA5 Q9HCN9

Explore the universe of human proteins at neXtProt for TNFSF4: NX_P23510

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P23510

    • TNFSF4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003317.1  
    ENSEMBL proteins: 
     ENSP00000356691   ENSP00000281834  

    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for TNFSF4 (OX40 Ligand/TNFSF4)
    Enzo Life Sciences proteins for TNFSF4
    OriGene Purified Protein: TNFSF4
    OriGene Protein Over-expression Lysate: TNFSF4
    OriGene Custom Protein Services for TNFSF4 
    GenScript Custom Purified and Recombinant Proteins Services for TNFSF4
    Novus Biologicals TNFSF4 Proteins
    Novus Biologicals TNFSF4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TNFSF4

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA17166734
    GO:0005887integral to plasma membrane NAS18397322
    GO:0009986cell surface IDA18397322
    GO:0016020membrane ----


    TNFSF4 for ontologies           About GeneDecksing



    TNFSF4 Antibody Products: 
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    ThermoFisher Antibodies for TNFSF4

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    Uscn ELISAs and CLIAs for TNFSF4

    Protein Domains /
    Families
    for TNFSF4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TNFSF4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006052 TNF
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR021184 TNF_CS

    Graphical View of Domain Structure for InterPro Entry P23510

    ProtoNet protein and cluster: P23510

    1 Blocks protein family: IPB006052 Tumor Necrosis Factor

    UniProtKB/Swiss-Prot: TNFL4_HUMAN, P23510
    Similarity: Belongs to the tumor necrosis factor family


    Function
    for TNFSF4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TNFL4_HUMAN, P23510
    Function: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production
    Induction: By HTLV-1 transactivator p40-Tax

         Genatlas biochemistry entry for TNFSF4:
    tumor necrosis factor (ligand) superfamily,member 4,tax-transcriptionally activated glycoprotein1,human OX-40
    ligand,expressed in T cell infected by HTLV1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFSF4
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFSF4 (see all 16):
    hsa-miR-125a-5p hsa-miR-16-2* hsa-miR-188-5p hsa-miR-3921 hsa-miR-877* hsa-miR-125b hsa-miR-3121-3p hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TNFSF4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFSF4 (see all 7)
    OriGene shRNA RFP: TNFSF4
    OriGene siRNA: TNFSF4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFSF4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TNFSF4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF4 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TNFSF4 (NM_003326)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFSF4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF4 

    Cell Line
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    LifeMap BioReagents: cell line associated with TNFSF4: PureStem Z11, Meso Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF4

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS7913952
    GO:0005125cytokine activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0032813tumor necrosis factor receptor superfamily binding ISS--


    TNFSF4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for TNFSF4: Tnfsf4tm1Sug Tnfsf4tm1Shr
         5 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Tnfsf4):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 

    TNFSF4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TNFSF4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/9 pathways (see all 9)
    		PEDF Induced Signaling1.00
    		RAR-Gamma-RXR-Alpha Degradation0.54
    		MIF Mediated Glucocorticoid Regulation0.73
    		STAT3 Pathway0.47
    		MIF Regulation of Innate Immune Cells0.71
    		Endothelin-1 Signaling Pathway0.44
    		IL-6 Pathway0.61
    		Cytokine-cytokine receptor interaction0.26
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    3Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    		Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway1.00
    		Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway1.00
    4PAK Pathway
    		PAK Pathway1.00
    		Antioxidant Action of Vitamin-C0.56
    5Akt Signaling
    		Akt Signaling1.00
    		p38 Signaling0.60

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TNFSF4
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    1 R&D Systems Pathway for TNFSF4
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFSF4 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Rho Family GTPases
    MIF Mediated Glucocorticoid Regulation

    1 GeneGo (Thomson Reuters) Pathway for TNFSF4
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    1 BioSystems Pathway for TNFSF4 
        TSLP Signaling Pathway


    1         Kegg Pathway  (Kegg details for TNFSF4):
        Cytokine-cytokine receptor interaction


    TNFSF4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFSF4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TNFSF4 (P235103 ENSP000002818344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF4P434893, ENSP000003685384I2D: score=2 STRING: ENSP00000368538
    TRAF2Q129333, ENSP000002476684I2D: score=1 STRING: ENSP00000247668
    About this table

    Gene Ontology (GO): 5/46 biological process terms (GO ID links to tree view) (see all 46):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001816cytokine production ----
    GO:0002215defense response to nematode ISS--
    GO:0002526acute inflammatory response ISS--
    GO:0002726positive regulation of T cell cytokine production ISS--
    GO:0002819regulation of adaptive immune response ISS--


    TNFSF4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TNFSF4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFSF4
    Search CenterWatch for drugs/clinical trials and news about TNFSF4 / TNFL4 

    Transcripts
    for TNFSF4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TNFSF4 gene: 
    NM_003326.3  

    Unigene Cluster for TNFSF4:

    Tumor necrosis factor (ligand) superfamily, member 4
    Hs.181097  [show with all ESTs]
    Unigene Representative Sequence: NM_003326
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367718(uc001giv.3) ENST00000281834(uc001giw.3) ENST00000488053


    miRNA
    Products:             		 OriGene 3'-UTR Clone: TNFSF4
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFSF4
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFSF4 (see all 16):
    hsa-miR-125a-5p hsa-miR-16-2* hsa-miR-188-5p hsa-miR-3921 hsa-miR-877* hsa-miR-125b hsa-miR-3121-3p hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TNFSF4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFSF4 (see all 7)
    OriGene shRNA RFP: TNFSF4
    OriGene siRNA: TNFSF4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFSF4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF4
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    GenScript: all cDNA clones in your preferred vector: TNFSF4 (NM_003326)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFSF4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFSF4

    Additional cDNA sequence: 

    AK297932.1 BC041663.1 CR542033.1 D90224.1 X79929.1 

    4 DOTS entries:

    DT.91757788  DT.452353  DT.100736968  DT.440139 

    24/86 AceView cDNA sequences (see all 86):

    BX389365 BC041663 AI018755 BG389239 BE349175 CF127212 BE670575 BX117627 
    CA443992 BI062717 X79929 BU740598 BX345040 AW304750 BQ420934 NM_003326 
    BM725742 AA806822 BE220598 BX104629 BG618149 AA883703 BU157377 BE672349 

    GeneLoc Exon Structure


    Expression
    for TNFSF4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFSF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGGCCTCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TNFSF4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeBody Subcutaneous White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    Primitive gut tube-like cells (A scalable, suspensi...)

    See TNFSF4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFSF4

    SOURCE GeneReport for Unigene cluster: Hs.181097
        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFSF4 (see all 7): 
              Th1/Th2 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Inflammasomes in human mouse rat
              Common Cytokines in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFSF4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF4

    Orthologs
    for TNFSF4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for TNFSF4 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tnfsf41 , 5 tumor necrosis factor (ligand) superfamily, member more1, 5 69.14(n)1
    46.29(a)1    		   1 (69.75 cM)5
    221641  NM_009452.21  NP_033478.11 
     1613954095 


    ENSEMBL Gene Tree for TNFSF4 (if available)
    TreeFam Gene Tree for TNFSF4 (if available) 

    Paralogs
    for TNFSF4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TNFSF4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/406 NCBI SNPs in TNFSF4 are shown (see all 406)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1129862141,2
    		--144377111(+) GAGAAG/CAGAAA 1 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs168455341,2
    		C,F,--144377248(+) ATTAAT/CAGTTG 1 -- ds50014Minor allele frequency- C:0.07NA WA 256
    rs759158091,2
    		C,F,--144377531(+) CCCGTC/TCTCCC 1 -- ds50011Minor allele frequency- T:0.05WA 118
    rs38619491,2
    		C,F,H,--144377924(+) GAGAAG/AGTTAC 1 -- ut31 ese3 trp315Minor allele frequency- A:0.07MN NS EA NA WA 2162
    rs168455361,2
    		C,F,--144377966(+) CATTTA/TATATG 1 -- ut318Minor allele frequency- T:0.10NA WA CSA EA 496
    rs168455431,2
    		C,F,H,--144378206(+) GAAGGA/GCATGA 1 -- ut31 ese323Minor allele frequency- G:0.11NA NS EA WA CSA 2480
    rs608186421,2
    		C,F,--144378975(+) ATTGTA/GGNNNN 1 -- ut316Minor allele frequency- G:0.12WA CSA NA EA 363
    rs618263451,2
    		C,F,--144379092(+) CAAAAA/CTTTAT 1 -- ut313Minor allele frequency- C:0.17NA 124
    rs779811001,2
    		--144379173(+) ACAGCG/ACCATA 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs173723091,2
    		C,F,H,--144379277(+) CCTTCT/CAGTTT 1 -- ut31 ese311Minor allele frequency- C:0.09NA NS EA 682

    HapMap Linkage Disequilibrium report for TNFSF4 (173152870 - 173176471 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TNFSF4: --
    Human Gene Mutation Database (HGMD): TNFSF4

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    Disorders / Diseases
    for TNFSF4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TNFSF4 for disorders           About GeneDecksing

    OMIM gene information: 603594   
    OMIM disorders: 608446  
    UniProtKB/Swiss-Prot: TNFL4_HUMAN, P23510
  • Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE
    • is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the
    skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the
    autoimmune system. Note=The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated
    with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought
    to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing
    peripheral tolerance

    20/47 diseases for TNFSF4 (see all 47):    About MalaCards
    myocardial infarction susceptibility    graft versus host disease    common variable immunodeficiency    myocardial infarction
    carotid artery disease    lupus erythematosus    mouth disease    systemic lupus erythematosus
    coronary heart disease    adult t-cell leukemia    lupus nephritis    ulcerative colitis
    essential hypertension    nephritis    cerebral infarction    hodgkin's lymphoma
    celiac disease    graves' disease    multiple myeloma    t-cell leukemia

    1 disease from the University of Copenhagen DISEASES database for TNFSF4:
    Systemic lupus erythematosus

    6 Novoseek disease relationships for TNFSF4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 55.9 5 9603911 (2), 1996093 (2), 9108415 (1)
    necrosis 55 30 16547002 (1), 18998106 (1), 9603911 (1), 18674525 (1) (see all 15)
    lupus erythematosus systemic 35.8 9 19092840 (2), 10906156 (1), 19083191 (1), 19778912 (1)
    tumors 35 27 16547002 (1), 18998106 (1), 9603911 (1), 18674525 (1) (see all 14)
    vasculitis 9.3 2 16443547 (1), 10906156 (1)
    leukemia 0 3 17618572 (2)

    Genetic Association Database (GAD): TNFSF4
    Human Genome Epidemiology (HuGE) Navigator: TNFSF4 (36 documents)

    Export disorders for TNFSF4 gene to outside databases

    Publications
    for TNFSF4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFSF4 gene, integrated from 9 sources (see all 137):
    (articles sorted by number of sources associating them with TNFSF4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax. (PubMed id 1996093)1, 2, 3, 9 Miura S.... Sugamura K. (1991)
    2. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. (PubMed id 8076595)1, 2, 3, 9 Baum P.R.... Fanslow W.C. (1994)
    3. New variations in human OX40 ligand (CD134L) gene. (PubMed id 11197696)1, 2, 4, 9 Hikami K.... Tokunaga K. (2000)
    4. Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. (PubMed id 18059267)1, 2 Cunninghame Graham D.S.... Vyse T.J. (2008)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. (PubMed id 15750594)1, 4 Wang X....Paigen B. (2005)
    7. Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor. (PubMed id 7913952)1, 2 Godfrey W.R.... Engleman E.G. (1994)
    8. Genetic variants of TNFSF4 and risk for carotid artery disease and stroke. (PubMed id 18998106)1, 9 Olofsson P.S....Hansson G.K. (2008)
    9. Association of TNFSF4 (OX40L) polymorphisms with susc eptibility to Systemic Sclerosis. (PubMed id 19778912)1, 9 Gourh P....Agarwal S.K. (2009)
    10. Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus. (PubMed id 19092840)1, 9 Delgado-Vega A.M....AlarcA^n-Riquelme M.E. (2008)

    External Searches for TNFSF4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    Genome Databases showing TNFSF4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7292 HGNC: 11934 AceView: TNFSF4 Ensembl:ENSG00000117586 euGenes: HUgn7292
    ECgene: TNFSF4 Kegg: 7292 H-InvDB: TNFSF4

    Other Databases showing TNFSF4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TNFSF4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFSF4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFSF4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TNFSF4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TNFSF4 gene:
    Search GeneIP for patents involving TNFSF4

    GeneCards and IP:
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