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Aliases for TNFSF18 Gene

Aliases for TNFSF18 Gene

  • TNF Superfamily Member 18 2 3 5
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 18 2 3
  • Glucocorticoid-Induced TNF-Related Ligand 3 4
  • Activation-Inducible TNF-Related Ligand 3 4
  • HGITRL 3 4
  • AITRL 3 4
  • GITRL 3 4
  • TL6 3 4
  • Glucocorticoid-Induced TNFR-Related Protein Ligand 3
  • Tumor Necrosis Factor Ligand Superfamily Member 18 3
  • Tumor Necrosis Factor Superfamily Member 18 3
  • Tumor Necrosis Factor Ligand 2A 3
  • AITR Ligand 3
  • GITR Ligand 3
  • TNLG2A 3

External Ids for TNFSF18 Gene

Previous GeneCards Identifiers for TNFSF18 Gene

  • GC01M170574
  • GC01M168639
  • GC01M169591
  • GC01M170249
  • GC01M170248
  • GC01M169740
  • GC01M171275
  • GC01M144235

Summaries for TNFSF18 Gene

Entrez Gene Summary for TNFSF18 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFSF18 Gene

TNFSF18 (TNF Superfamily Member 18) is a Protein Coding gene. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Akt Signaling. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding.

UniProtKB/Swiss-Prot for TNFSF18 Gene

  • Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).

Gene Wiki entry for TNFSF18 Gene

Additional gene information for TNFSF18 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF18 Gene

Genomics for TNFSF18 Gene

Regulatory Elements for TNFSF18 Gene

Enhancers for TNFSF18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H172902 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +144.3 144271 9 TBL1XR1 RAD21 CHAMP1 ZNF766 ELK1 FOS RUNX3 CAVIN1 ZBTB11 CEBPB KLHL20 TNFSF18 DNM3OS GAS5-AS1 ENSG00000224228 GAS5 ENSG00000224000 AIMP1P2
GH01H172913 1.5 FANTOM5 Ensembl ENCODE dbSUPER 13.3 +134.1 134119 6 JUN FEZF1 RAD21 RFX5 ZNF766 POLR2A SMC3 RCOR1 FOS PRDM10 TNFSF18 ENSG00000224228 GAS5 ENSG00000224000
GH01H173121 1.6 FANTOM5 Ensembl ENCODE 10.9 -72.3 -72346 2 PKNOX1 FOXA2 ARID4B FEZF1 YY1 ELK1 FOS REST KAT8 NFIL3 TNFSF18 GOT2P2 PIR51500
GH01H172966 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +81.4 81406 5 FOXA2 JUN BATF RFX5 TEAD3 FOSL1 GATA3 GATA2 RCOR1 TEAD1 TNFSF18 ENSG00000224228 KLHL20 ENSG00000224000
GH01H173200 1.5 Ensembl ENCODE dbSUPER 10.1 -153.9 -153914 7 HDGF PKNOX1 MLX ARID4B FEZF1 ZNF143 ATF7 RUNX3 JUNB REST ENSG00000224228 TNFSF18 ENSG00000226375 TNFSF4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFSF18 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNFSF18 Gene

Chromosome:
1
Start:
173,039,960 bp from pter
End:
173,050,963 bp from pter
Size:
11,004 bases
Orientation:
Minus strand

Genomic View for TNFSF18 Gene

Genes around TNFSF18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF18 Gene

Proteins for TNFSF18 Gene

  • Protein details for TNFSF18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNG2-TNF18_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 18
    Protein Accession:
    Q9UNG2
    Secondary Accessions:
    • A9IQG8
    • O95852
    • Q6ISV1

    Protein attributes for TNFSF18 Gene

    Size:
    199 amino acids
    Molecular mass:
    22724 Da
    Quaternary structure:
    • Homodimer (By similarity). Homotrimer.
    SequenceCaution:
    • Sequence=AAH93986.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI12033.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ89227.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36082.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW90937.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNFSF18 Gene

neXtProt entry for TNFSF18 Gene

Post-translational modifications for TNFSF18 Gene

  • Glycosylation at posLast=151151 and Asn183

Other Protein References for TNFSF18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFSF18 (GITR Ligand/TNFSF18)
  • Santa Cruz Biotechnology (SCBT) Antibodies for TNFSF18

No data available for DME Specific Peptides for TNFSF18 Gene

Domains & Families for TNFSF18 Gene

Gene Families for TNFSF18 Gene

Protein Domains for TNFSF18 Gene

Suggested Antigen Peptide Sequences for TNFSF18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UNG2

UniProtKB/Swiss-Prot:

TNF18_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF18: view

Function for TNFSF18 Gene

Molecular function for TNFSF18 Gene

GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 18,expressed in several peripheral tissues and vascular endothelial cellsl,maybe involved in interaction between activated T lymphocytes and endothelial cells
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated after stimulation by bacterial lipopolysaccharides (LPS).

Phenotypes From GWAS Catalog for TNFSF18 Gene

Gene Ontology (GO) - Molecular Function for TNFSF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10074428
GO:0005125 cytokine activity IEA --
GO:0032813 tumor necrosis factor receptor superfamily binding ISS --
genes like me logo Genes that share ontologies with TNFSF18: view
genes like me logo Genes that share phenotypes with TNFSF18: view

Animal Models for TNFSF18 Gene

MGI Knock Outs for TNFSF18:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TNFSF18
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TNFSF18 Gene

Localization for TNFSF18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF18 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF18 gene
Compartment Confidence
plasma membrane 5
extracellular 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for TNFSF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFSF18: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFSF18 Gene

Pathways & Interactions for TNFSF18 Gene

genes like me logo Genes that share pathways with TNFSF18: view

Interacting Proteins for TNFSF18 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000385470%0d%0a9606.ENSP00000328207%0d%0a
Selected Interacting proteins: ENSP00000385470 Q9UNG2-TNF18_HUMAN for TNFSF18 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TNFSF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002309 T cell proliferation involved in immune response ISS,IBA --
GO:0002376 immune system process IEA --
GO:0002687 positive regulation of leukocyte migration IMP 23892569
GO:0007165 signal transduction TAS 10074428
genes like me logo Genes that share ontologies with TNFSF18: view

No data available for SIGNOR curated interactions for TNFSF18 Gene

Drugs & Compounds for TNFSF18 Gene

(1) Drugs for TNFSF18 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pomalidomide (CC-4047) Pharma Immunomodulator,antumor/anti-angiogenic 0

(1) ApexBio Compounds for TNFSF18 Gene

Compound Action Cas Number
Pomalidomide (CC-4047) Immunomodulator,antumor/anti-angiogenic 19171-19-8
genes like me logo Genes that share compounds with TNFSF18: view

Drug Products

Transcripts for TNFSF18 Gene

mRNA/cDNA for TNFSF18 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFSF18 Gene

Tumor necrosis factor (ligand) superfamily, member 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TNFSF18
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF18 Gene

No ASD Table

Relevant External Links for TNFSF18 Gene

GeneLoc Exon Structure for
TNFSF18
ECgene alternative splicing isoforms for
TNFSF18

Expression for TNFSF18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFSF18 Gene

mRNA differential expression in normal tissues according to GTEx for TNFSF18 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of TNFSF18 Gene:

TNFSF18

SOURCE GeneReport for Unigene cluster for TNFSF18 Gene:

Hs.248197

mRNA Expression by UniProt/SwissProt for TNFSF18 Gene:

Q9UNG2-TNF18_HUMAN
Tissue specificity: Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.

Evidence on tissue expression from TISSUES for TNFSF18 Gene

  • Nervous system(4.2)
  • Lymph node(2.2)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with TNFSF18: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF18 Gene

Orthologs for TNFSF18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TNFSF18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFSF18 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia TNFSF18 33 34
  • 82.3 (n)
dog
(Canis familiaris)
Mammalia TNFSF18 33 34
  • 81.56 (n)
rat
(Rattus norvegicus)
Mammalia Tnfsf18 33
  • 72.35 (n)
mouse
(Mus musculus)
Mammalia Tnfsf18 33 16 34
  • 69.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TNFSF18 34
  • 32 (a)
OneToOne
Species where no ortholog for TNFSF18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF18 Gene

ENSEMBL:
Gene Tree for TNFSF18 (if available)
TreeFam:
Gene Tree for TNFSF18 (if available)

Paralogs for TNFSF18 Gene

No data available for Paralogs for TNFSF18 Gene

Variants for TNFSF18 Gene

Sequence variations from dbSNP and Humsavar for TNFSF18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000088113 -- 173,047,230(+) GTTTC(C/T)TGGAG intron-variant
rs1000371534 -- 173,043,765(+) GCCTG(C/G)TTTAC intron-variant
rs1000689057 -- 173,048,933(+) TATCA(C/T)GTATG intron-variant
rs1000906986 -- 173,052,297(+) AGTAG(C/T)GTCTC upstream-variant-2KB
rs1001331706 -- 173,048,549(+) CTGAG(A/G)GATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFSF18 Gene

Variant ID Type Subtype PubMed ID
nsv831904 CNV gain+loss 17160897

Variation tolerance for TNFSF18 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFSF18 Gene

Human Gene Mutation Database (HGMD)
TNFSF18
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFSF18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF18 Gene

Disorders for TNFSF18 Gene

Relevant External Links for TNFSF18

Genetic Association Database (GAD)
TNFSF18
Human Genome Epidemiology (HuGE) Navigator
TNFSF18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFSF18

No disorders were found for TNFSF18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFSF18 Gene

Publications for TNFSF18 Gene

  1. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. (PMID: 10074428) Gurney AL … Ashkenazi A (Current biology : CB 1999) 2 3 4 22 60
  2. Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. (PMID: 10037686) Kwon B … Kwon BS (The Journal of biological chemistry 1999) 2 3 4 60
  3. Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion. (PMID: 23892569) Lacal PM … Nocentini G (The Journal of pharmacology and experimental therapeutics 2013) 3 4 60
  4. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 45 60
  5. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 45 60

Products for TNFSF18 Gene

Sources for TNFSF18 Gene

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