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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFSF18 Gene

protein-coding   GIFtS: 59
GCID: GC01M173009

tumor necrosis factor (ligand) superfamily, member 18
 Explore 14 diseases affiliated with
TNFSF18 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TNFSF18    

Aliases
for TNFSF18 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Necrosis Factor (Ligand) Superfamily, Member 181 2     Glucocorticoid-Induced TNF-Related Ligand2 3
AITRL1 2 3 5     AITR Ligand2
TL61 2 3     GITR Ligand2
HGITRL1     Glucocorticoid-Induced TNFR-Related Protein Ligand2
GITRL2 3 5     Tumor Necrosis Factor Ligand Superfamily Member 182
Activation-Inducible TNF-Related Ligand2 3     

External Ids:    HGNC: 119321   Entrez Gene: 89952   Ensembl: ENSG000001203377   OMIM: 6038985   UniProtKB: Q9UNG23   

Export aliases for TNFSF18 gene to outside databases

Previous GC identifers: GC01M170574 GC01M168639 GC01M169591 GC01M170249 GC01M170248 GC01M169740 GC01M171275 GC01M144235


Summaries
for TNFSF18 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TNFSF18:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This
cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in
peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important
for interaction between T lymphocytes and endothelial cells. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNF18_HUMAN, Q9UNG2
Function: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower
the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated
T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B

Gene Wiki entry for TNFSF18


Genomic Views
for TNFSF18 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFSF18 gene promoter:
         C/EBPbeta   Sox5   AML1a   RREB-1   LCR-F1   SRY   Ik-2   Sox9   LyF-1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNFSF18 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFSF18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFSF18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q23

TNFSF18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFSF18 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M173009:  view genomic region     (about GC identifiers)

Start:
 173,009,100 bp from pter      End:
 173,020,103 bp from pter
Size:
 11,004 bases      Orientation:
 minus strand

Proteins
for TNFSF18 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TNF18_HUMAN, Q9UNG2 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 18  
Size: 199 amino acids; 22724 Da
Subunit: Homodimer (By similarity). Homotrimer
Subcellular location: Cell membrane; Single-pass type II membrane protein
Caution: It is uncertain whether Met-1 or Met-23 is the initiator
Sequence caution: Sequence=AAH93986.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI12033.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAQ89227.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG36082.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=EAW90937.1; Type=Erroneous initiation; Note=Translation N-terminally
extended;
5 PDB 3D structures from and Proteopedia for TNFSF18:
2Q1M (3D)        2R30 (3D)        2R32 (3D)        3B93 (3D)        3B94 (3D)    
Secondary accessions: A9IQG8 O95852 Q6ISV1

Explore the universe of human proteins at neXtProt for TNFSF18: NX_Q9UNG2

TNFSF18 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_005083.2  
ENSEMBL proteins: 
 ENSP00000385470   ENSP00000239468  

Human Recombinant Protein Products: 
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R&D Systems Recombinant & Natural Proteins for TNFSF18 (GITR Ligand/TNFSF18)
Enzo Life Sciences proteins for TNFSF18
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OriGene Protein Over-expression Lysate: TNFSF18
OriGene Custom Protein Services for TNFSF18 
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Novus Biologicals TNFSF18 Proteins
Novus Biologicals TNFSF18 Lysates
Browse Sino Biological Recombinant Proteins
ProSpec Recombinant Protein for TNFSF18
Uscn Proteins for TNFSF18

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--
GO:0005886plasma membrane IEA--
GO:0009986cell surface ISS--
GO:0016021integral to membrane IEA--


TNFSF18 for ontologies           About GeneDecksing



TNFSF18 Antibody Products: 
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Search for Antibodies for TNFSF18 at Abcam  
Uscn Antibodies for TNFSF18
ThermoFisher Antibodies for TNFSF18

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Uscn ELISAs and CLIAs for TNFSF18

Protein Domains /
Families
for TNFSF18 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
TNFSF18 for domains           About GeneDecksing

2 InterPro domains/families:
 IPR006052 TNF
 IPR008983 Tumour_necrosis_fac-like_dom

Graphical View of Domain Structure for InterPro Entry Q9UNG2

ProtoNet protein and cluster: Q9UNG2

1 Blocks protein family: IPB006052 Tumor Necrosis Factor

UniProtKB/Swiss-Prot: TNF18_HUMAN, Q9UNG2
Similarity: Belongs to the tumor necrosis factor family


Function
for TNFSF18 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: TNF18_HUMAN, Q9UNG2
Function: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower
the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated
T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B
Induction: Up-regulated after stimulation by bacterial lipopolysaccharides (LPS)

     Genatlas biochemistry entry for TNFSF18:
tumor necrosis factor (ligand) superfamily,member 18,expressed in several peripheral tissues and vascular endothelial
cellsl,maybe involved in interaction between activated T lymphocytes and endothelial cells

miRNA
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Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFSF18
1 QIAGEN miScript miRNA Assays for microRNA that regulate TNFSF18:
hsa-miR-3150b-3p
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFSF18 (see all 4)
OriGene shRNA RFP: TNFSF18
OriGene siRNA: TNFSF18
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFSF18

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for TNFSF18

Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF18 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF18 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: TNFSF18 (NM_005092)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFSF18
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF18 

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for TNFSF18
LifeMap BioReagents: cell line associated with TNFSF18: PureStem Z11, Meso Progenitor

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF18

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding TAS10074428
GO:0005125cytokine activity IEA--
GO:0005164tumor necrosis factor receptor binding IEA--
GO:0005515protein binding ----
GO:0032813tumor necrosis factor receptor superfamily binding ISS--


TNFSF18 for ontologies           About GeneDecksing



Pathways & Interactions
for TNFSF18 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1PEDF Induced Signaling
8/9 pathways (see all 9)
PEDF Induced Signaling1.00
RAR-Gamma-RXR-Alpha Degradation0.54
MIF Mediated Glucocorticoid Regulation0.73
STAT3 Pathway0.47
MIF Regulation of Innate Immune Cells0.71
Endothelin-1 Signaling Pathway0.44
IL-6 Pathway0.61
Cytokine-cytokine receptor interaction0.26
2Rho Family GTPases
Rho Family GTPases1.00
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61
3PAK Pathway
PAK Pathway1.00
Antioxidant Action of Vitamin-C0.56
4Akt Signaling
Akt Signaling1.00
p38 Signaling0.60
5Apoptosis and survival_Apoptotic TNF-family pathways
Apoptosis and survival_Apoptotic TNF-family pathways1.00
Apoptosis and survival Apoptotic TNF-family pathways1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TNFSF18
    Apoptosis and survival Apoptotic TNF-family pathways

1 R&D Systems Pathway for TNFSF18
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFSF18 (see all 17)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
Rho Family GTPases
MIF Mediated Glucocorticoid Regulation

1 GeneGo (Thomson Reuters) Pathway for TNFSF18
    Apoptosis and survival Apoptotic TNF-family pathways


1         Kegg Pathway  (Kegg details for TNFSF18):
    Cytokine-cytokine receptor interaction


TNFSF18 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFSF18

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TNFSF18 (Q9UNG23 ENSP000003854704) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TNFRSF18Q9Y5U53, ENSP000003282074I2D: score=1 STRING: ENSP00000328207
About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002309T cell proliferation involved in immune response ISS--
GO:0007165signal transduction TAS10074428
GO:0007267cell-cell signaling TAS10074428
GO:0033209tumor necrosis factor-mediated signaling pathway ISS--
GO:0042129regulation of T cell proliferation ISS--


TNFSF18 for ontologies           About GeneDecksing



Drugs & Compounds
for TNFSF18 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNFSF18
Search CenterWatch for drugs/clinical trials and news about TNFSF18 / TNF18 

Transcripts
for TNFSF18 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for TNFSF18 gene: 
NM_005092.3  

Unigene Cluster for TNFSF18:

Tumor necrosis factor (ligand) superfamily, member 18
Hs.248197  [show with all ESTs]
Unigene Representative Sequence: AY358868
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000404377(uc001giu.2) ENST00000239468

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFSF18
1 QIAGEN miScript miRNA Assays for microRNA that regulate TNFSF18:
hsa-miR-3150b-3p
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFSF18 (see all 4)
OriGene shRNA RFP: TNFSF18
OriGene siRNA: TNFSF18
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFSF18
Clone
Products:     		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF18 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF18 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: TNFSF18 (NM_005092)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFSF18
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF18 
Primer
Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFSF18
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNFSF18
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFSF18
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFSF18

Additional cDNA sequence: 

AF117713.1 AF125303.1 AK313273.1 AY358868.1 BC069111.1 BC069319.1 BC093986.1 BC112032.1 

1 DOTS entry:

DT.91709182 

7 AceView cDNA sequences:

BC069111 NM_005092 AF125303 BC069319 BX473859 AY358868 AF117713 

GeneLoc Exon Structure


Expression
for TNFSF18 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNFSF18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGAGGTGCC

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

TNFSF18 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
Stem Cell Differentiation: 4 LifeMap Cells 
NameCategory
PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
PureStem™ progenitor W10 (Embryonic Progenitor Cell)
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See TNFSF18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFSF18

SOURCE GeneReport for Unigene cluster: Hs.248197

UniProtKB/Swiss-Prot: TNF18_HUMAN, Q9UNG2
Tissue specificity: Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells

    SABiosciences Expression via Pathway-Focused PCR Arrays including TNFSF18: 
          TNF Ligands & Receptors in human mouse rat
          Common Cytokines in human mouse rat
          Apoptosis 384HT in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFSF18
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF18

Orthologs
for TNFSF18 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of human and mouse.

Orthologs for TNFSF18 gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Tnfsf181 , 5 tumor necrosis factor (ligand) superfamily, member more1, 5 68.63(n)1
52.94(a)1		   1 (69.75 cM)5
2408731  NM_183391.31  NP_899247.31 
 1614946555 


ENSEMBL Gene Tree for TNFSF18 (if available)
TreeFam Gene Tree for TNFSF18 (if available) 

Paralogs
for TNFSF18 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for TNFSF18 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/207 NCBI SNPs in TNFSF18 are shown (see all 207)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 1 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1159776221,2
F,--173009891(+) AAAGCA/CCCCTG 1 -- ds50011Minor allele frequency- C:0.02NA 120
rs741295161,2
C,--173009999(+) TTATCT/CTCTAA 1 -- ds50012Minor allele frequency- C:0.09WA 120
rs412645541,2
--173010029(+) GGGTAC/TGGTAG 1 -- ds50010--------
rs1928001961,2
--173010164(+) CCTTTC/TTGCAT 1 -- ds50010--------
rs1854056521,2
--173010179(+) GGTAAA/GTCTTC 1 -- ds50010--------
rs412645561,2
--173010192(+) TGGGAA/GTAGAA 1 -- ds50010--------
rs794681321,2
F,--173010208(+) TTTTTC/GCACTC 1 -- ds50011Minor allele frequency- G:0.03WA 118
rs412645581,2
--173010290(+) GGATTA/GATGAA 1 -- ds50010--------
rs1928480581,2
--173010446(+) TCCCTA/CCAATC 1 -- ut310--------
rs2006488071,2
--173010483(+) GAAGGA/GAATGA 1 -- ut310--------

HapMap Linkage Disequilibrium report for TNFSF18 (173009100 - 173020103 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for TNFSF18: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFSF18
DNA2.0 Custom Variant and Variant Library Synthesis for TNFSF18

Disorders / Diseases
for TNFSF18 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
TNFSF18 for disorders           About GeneDecksing

OMIM gene information: 603898    OMIM disorders: --

14 diseases for TNFSF18:    About MalaCards
atopic dermatitis    celiac disease    multiple myeloma    dermatitis
hepatitis c    crohn's disease    hepatitis b    myeloma
meningioma    hepatitis    breast cancer    retinitis
leukemia    lumbar disc herniation

2 Novoseek disease relationships for TNFSF18 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis 46.5 2 16179414 (1), 17963343 (1)
tumors 26.4 2 16179414 (1), 17963343 (1)

Human Genome Epidemiology (HuGE) Navigator: TNFSF18 (15 documents)

Export disorders for TNFSF18 gene to outside databases

Publications
for TNFSF18 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TNFSF18 gene, integrated from 9 sources (see all 45):
(articles sorted by number of sources associating them with TNFSF18)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. (PubMed id 10074428)1, 2, 3, 9 Gurney A.L....Ashkenazi A. (1999)
  2. Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. (PubMed id 10037686)1, 2, 3 Kwon B.... Kwon B.S. (1999)
  3. Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function. (PubMed id 18040044)1, 2 Chattopadhyay K....Almo S.C. (2007)
  4. Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells. (PubMed id 17449724)1, 2 Tuyaerts S....Aerts J.L. (2007)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  7. Osteostat/tumor necrosis factor superfamily 18 inhibits osteoclastogenesis and is selectively expressed by vascular endothelial cells. (PubMed id 16179414)1, 9 Nardelli B....Moore P.A. (2006)
  8. Induction of GITRL expression in human keratinocytes b y Th2 cytokines and TNF-a: implications for atopic dermatitis. (PubMed id 22417213)1 Byrne A.M....Leung D.Y. (2012)
  9. IFN-b induces the proliferation of CD4+CD25+Foxp3+ reg ulatory T cells through upregulation of GITRL on dendritic cells in the treatmen t of multiple sclerosis. (PubMed id 22112394)1 Chen M....Hong J. (2012)
  10. GITR ligand provided by thrombopoietic cells inhibits NK cell antitumor activity. (PubMed id 22649191)1 Placke T....Kopp H.G. (2012)

External Searches for TNFSF18 gene

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Genome Databases showing TNFSF18 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8995 HGNC: 11932 AceView: TNFSF18 Ensembl:ENSG00000120337 euGenes: HUgn8995
ECgene: TNFSF18 Kegg: 8995 H-InvDB: TNFSF18

Other Databases showing TNFSF18 gene

(According to HUGE)
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Specialized Databases showing TNFSF18 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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PharmGKB entry for TNFSF18 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFSF18 Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property
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