Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TNFSF18 Gene

protein-coding   GIFtS: 61
GCID: GC01M173009

Tumor Necrosis Factor (Ligand) Superfamily, Member 18

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tumor Necrosis Factor (Ligand) Superfamily, Member 181 2     hGITRL2 3
AITRL2 3 5     AITR Ligand2
GITRL2 3 5     GITR Ligand2
Activation-Inducible TNF-Related Ligand2 3     Glucocorticoid-Induced TNFR-Related Protein Ligand2
Glucocorticoid-Induced TNF-Related Ligand2 3     Tumor Necrosis Factor Ligand Superfamily Member 182
TL62 3     

External Ids:    HGNC: 119321   Entrez Gene: 89952   Ensembl: ENSG000001203377   OMIM: 6038985   UniProtKB: Q9UNG23   

Export aliases for TNFSF18 gene to outside databases

Previous GC identifers: GC01M170574 GC01M168639 GC01M169591 GC01M170249 GC01M170248 GC01M169740 GC01M171275 GC01M144235


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TNFSF18 Gene:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This
cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in
peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be
important for interaction between T lymphocytes and endothelial cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFSF18 Gene:
TNFSF18 (tumor necrosis factor (ligand) superfamily, member 18) is a protein-coding gene. Diseases associated with TNFSF18 include endotheliitis, and atopic dermatitis. GO annotations related to this gene include tumor necrosis factor receptor binding and receptor binding.

UniProtKB/Swiss-Prot: TNF18_HUMAN, Q9UNG2
Function: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and
lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated
T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B

Gene Wiki entry for TNFSF18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFSF18 gene promoter:
         C/EBPbeta   Sox5   AML1a   RREB-1   LCR-F1   SRY   Ik-2   Sox9   LyF-1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFSF18 promoter sequence
   Search Chromatin IP Primers for TNFSF18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFSF18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q23

TNFSF18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFSF18 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M173009:  view genomic region     (about GC identifiers)

Start:
173,009,100 bp from pter      End:
173,020,103 bp from pter
Size:
11,004 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TNF18_HUMAN, Q9UNG2 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 18  
Size: 199 amino acids; 22724 Da
Subunit: Homodimer (By similarity). Homotrimer
Caution: It is uncertain whether Met-1 or Met-23 is the initiator
Sequence caution: Sequence=AAH93986.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI12033.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAQ89227.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG36082.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=EAW90937.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
5 PDB 3D structures from and Proteopedia for TNFSF18:
2Q1M (3D)        2R30 (3D)        2R32 (3D)        3B93 (3D)        3B94 (3D)    
Secondary accessions: A9IQG8 O95852 Q6ISV1

Explore the universe of human proteins at neXtProt for TNFSF18: NX_Q9UNG2

Explore proteomics data for TNFSF18 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn151, Asn183

  • See TNFSF18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005083.2  
    ENSEMBL proteins: 
     ENSP00000385470   ENSP00000239468  

    TNFSF18 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TNFSF18 (GITR Ligand/TNFSF18)
    Enzo Life Sciences proteins for TNFSF18
    OriGene Purified Protein for TNFSF18
    OriGene Protein Over-expression Lysate for TNFSF18
    OriGene MassSpec for TNFSF18
    OriGene Custom Protein Services for TNFSF18
    GenScript Purified and Recombinant Proteins for TNFSF18
    Novus Biologicals TNFSF18 Proteins
    Novus Biologicals TNFSF18 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TNFSF18
    Cloud-Clone Corp. Proteins for TNFSF18

    TNFSF18 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TNFSF18 (GITR Ligand/TNFSF18)
    OriGene Antibodies for TNFSF18
    OriGene Custom Antibody Services for TNFSF18
    Novus Biologicals TNFSF18 Antibodies
    Abcam antibodies for TNFSF18
    Cloud-Clone Corp. Antibodies for TNFSF18
    ThermoFisher Antibodies for TNFSF18
    LSBio Antibodies in human, mouse, rat for TNFSF18

    TNFSF18 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TNFSF18
    R&D Systems ELISAs for TNFSF18 (GITR Ligand/TNFSF18)
    GenScript Custom Assay Services for TNFSF18
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TNFSF18
    Cloud-Clone Corp. CLIAs for TNFSF18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TNFSF: Tumor necrosis factor (ligand) superfamily

    2 InterPro protein domains:
     IPR006052 TNF_dom
     IPR008983 Tumour_necrosis_fac-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UNG2

    ProtoNet protein and cluster: Q9UNG2

    1 Blocks protein domain: IPB006052 Tumor Necrosis Factor

    UniProtKB/Swiss-Prot: TNF18_HUMAN, Q9UNG2
    Similarity: Belongs to the tumor necrosis factor family


    TNFSF18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNF18_HUMAN, Q9UNG2
    Function: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and
    lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated
    T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B
    Induction: Up-regulated after stimulation by bacterial lipopolysaccharides (LPS)

         Genatlas biochemistry entry for TNFSF18:
    tumor necrosis factor (ligand) superfamily,member 18,expressed in several peripheral tissues and vascular
    endothelial cellsl,maybe involved in interaction between activated T lymphocytes and endothelial cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS10074428
    GO:0005125cytokine activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding ----
    GO:0032813tumor necrosis factor receptor superfamily binding ISS--
         
    TNFSF18 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFSF18
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNFSF18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFSF18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFSF18

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TNFSF18 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TNFSF18:
    hsa-miR-3150b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TNFSF18
    Predesigned siRNA for gene silencing in human, mouse, rat TNFSF18

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TNFSF18

    Clone
    Products:
         
    OriGene clones in human, mouse for TNFSF18 (see all 7)
    OriGene ORF clones in mouse, rat for TNFSF18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNFSF18 (NM_005092)
    Sino Biological Human cDNA Clone for TNFSF18
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFSF18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF18

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TNFSF18
    ESI BIO PureStem Progenitor for TNFSF18: 
    PureStem Z11, Meso Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TNF18_HUMAN, Q9UNG2: Cell membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    cytosol1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface ISS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    TNFSF18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TNFSF18 About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    3Akt Signaling
    Akt Signaling0.60
    p38 Signaling0.60
    4PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56
    5TNF Signaling
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFSF18
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFSF18 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Rho Family GTPases
    MIF Mediated Glucocorticoid Regulation

    1 GeneGo (Thomson Reuters) Pathway for TNFSF18
        Apoptosis and survival Apoptotic TNF-family pathways



    1 Kegg Pathway  (Kegg details for TNFSF18):
        Cytokine-cytokine receptor interaction


    TNFSF18 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFSF18: 
              TNF Ligands & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Apoptosis 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFSF18

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TNFSF18 (Q9UNG23 ENSP000003854704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF18Q9Y5U53, ENSP000003282074I2D: score=1 STRING: ENSP00000328207
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002309T cell proliferation involved in immune response ISS--
    GO:0006955immune response ----
    GO:0007165signal transduction TAS10074428
    GO:0007267cell-cell signaling TAS10074428
    GO:0033209tumor necrosis factor-mediated signaling pathway ISS--

    TNFSF18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFSF18 (TNF18)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TNFSF18 gene: 
    NM_005092.3  

    Unigene Cluster for TNFSF18:

    Tumor necrosis factor (ligand) superfamily, member 18
    Hs.248197  [show with all ESTs]
    Unigene Representative Sequence: AY358868
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404377(uc001giu.2) ENST00000239468

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TNFSF18 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TNFSF18:
    hsa-miR-3150b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TNFSF18
    Predesigned siRNA for gene silencing in human, mouse, rat TNFSF18
    Clone
    Products:
         
    OriGene clones in human, mouse for TNFSF18 (see all 7)
    OriGene ORF clones in mouse, rat for TNFSF18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNFSF18 (NM_005092)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFSF18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF18
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TNFSF18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNFSF18
      QuantiTect SYBR Green Assays in human, mouse, rat TNFSF18
      QuantiFast Probe-based Assays in human, mouse, rat TNFSF18

    Additional mRNA sequence: 

    AF117713.1 AF125303.1 AK313273.1 AY358868.1 BC069111.1 BC069319.1 BC093986.1 BC112032.1 

    1 DOTS entry:

    DT.91709182 

    7 AceView cDNA sequences:

    NM_005092 AF125303 BC069319 BC069111 BX473859 AF117713 AY358868 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TNFSF18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGAGGTGCC
    TNFSF18 Expression
    About this image


    TNFSF18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
    TNFSF18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFSF18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248197

    UniProtKB/Swiss-Prot: TNF18_HUMAN, Q9UNG2
    Tissue specificity: Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFSF18: 
              TNF Ligands & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Apoptosis 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TNFSF18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNFSF18
    QuantiTect SYBR Green Assays in human, mouse, rat TNFSF18
    QuantiFast Probe-based Assays in human, mouse, rat TNFSF18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for TNFSF18 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfsf181 , 5 tumor necrosis factor (ligand) superfamily, member more1, 5 69.41(n)1
    53.53(a)1
      1 (69.75 cM)5
    2408731  NM_183391.31  NP_899247.31 
     1614946555 


    ENSEMBL Gene Tree for TNFSF18 (if available)
    TreeFam Gene Tree for TNFSF18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TNFSF18 (see all 256)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1159776221,2
    C,F--173009891(+) AAAGCA/CCCCTG 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs741295161,2
    C,F--173009999(+) TTATCT/CTCTAA 1 -- ds50012Minor allele frequency- C:0.09WA 120
    rs412645541,2
    F--173010029(+) GGGTAC/TGGTAG 1 -- ds50010--------
    rs1928001961,2
    --173010164(+) CCTTTC/TTGCAT 1 -- ds50010--------
    rs1854056521,2
    --173010179(+) GGTAAA/GTCTTC 1 -- ds50010--------
    rs412645561,2
    --173010192(+) TGGGAA/GTAGAA 1 -- ds50010--------
    rs794681321,2
    F--173010208(+) TTTTTC/GCACTC 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs412645581,2
    --173010290(+) GGATTA/GATGAA 1 -- ds50010--------
    rs1928480581,2
    --173010446(+) TCCCTA/CCAATC 1 -- ut310--------
    rs2006488071,2
    C--173010483(+) GAAGGA/GAATGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TNFSF18 (173009100 - 173020103 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TNFSF18:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831904CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): TNFSF18
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFSF18
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFSF18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603898    OMIM disorders: --

    20 diseases for TNFSF18:    
    About MalaCards
    endotheliitis    atopic dermatitis    celiac disease    crohn's disease
    childhood leukemia    multiple myeloma    meningioma    dermatitis
    hepatitis c virus    myeloma    hepatitis c    multiple sclerosis
    hepatitis    hepatitis b    inflammatory bowel disease    retinitis
    systemic lupus erythematosus    lupus erythematosus    breast cancer    leukemia


    TNFSF18 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    2 Novoseek inferred disease relationships for TNFSF18 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 46.5 2 16179414 (1), 17963343 (1)
    tumors 26.4 2 16179414 (1), 17963343 (1)

    Genetic Association Database (GAD): TNFSF18
    Human Genome Epidemiology (HuGE) Navigator: TNFSF18 (15 documents)

    Export disorders for TNFSF18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TNFSF18 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with TNFSF18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. (PubMed id 10074428)1, 2, 3, 9 Gurney A.L....Ashkenazi A. (Curr. Biol. 1999)
    2. Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. (PubMed id 10037686)1, 2, 3 Kwon B.... Kwon B.S. (J. Biol. Chem. 1999)
    3. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    4. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    6. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    7. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. (PubMed id 19760754)1, 4 TAPrkvist L....Pettersson S. (Inflamm. Bowel Dis. 2010)
    8. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8995 HGNC: 11932 AceView: TNFSF18 Ensembl:ENSG00000120337 euGenes: HUgn8995
    ECgene: TNFSF18 Kegg: 8995 H-InvDB: TNFSF18

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TNFSF18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFSF18 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TNFSF18 gene:
    Search GeneIP for patents involving TNFSF18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for TNFSF18 (GITR Ligand/TNFSF18)   Browse Cell Culture Products  
     ELISAs for TNFSF18 (GITR Ligand/TNFSF18)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for TNFSF18 (GITR Ligand/TNFSF18)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TNFSF18   OriGene RNAi products in human, mouse, rat for TNFSF18  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TNFSF18  
     OriGene MassSpec something-or-other for TNFSF18   OriGene clones in human, mouse for TNFSF18  
     OriGene qSTAR qPCR primer pairs in human, mouse for TNFSF18   OriGene Purified Protein for TNFSF18  
     OriGene ORF clones in mouse, rat for TNFSF18   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TNFSF18   OriGene Custom Protein Services for TNFSF18  

     
     
     Block miRNA regulation of human, mouse, rat TNFSF18 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TNFSF18
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFSF18 Predesigned siRNA for gene silencing in human, mouse, rat TNFSF18
     QuantiFast Probe-based Assays in human, mouse, rat TNFSF18 QuantiTect SYBR Green Assays in human, mouse, rat TNFSF18
     PCR Arrays including human, mouse, rat TNFSF18 Search Chromatin IP Primers for TNFSF18
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TNFSF18  GeneGlobe Interaction Network for TNFSF18
     Regulatory tfbs in TNFSF18 promoter
     GenScript Purified and Recombinant Proteins for TNFSF18 GenScript cDNA clones with any tag delivered in your preferred vector for TNFSF18
     GenScript Custom Assay Services for TNFSF18 GenScript Custom overexpressing Cell Line Services for TNFSF18
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TNFSF18 (TNF18)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TNFSF18
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for TNFSF18
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TNFSF18 antibodies
     TNFSF18 proteins
     TNFSF18 lysates
     Antibodies for TNFSF18
     See all of Abcam's Antibodies, Kits and Proteins for TNFSF18
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TNFSF18
     Proteins for TNFSF18
     Antibodies for TNFSF18
     ELISAs for TNFSF18
     CLIAs for TNFSF18



     PureStem Progenitor for TNFSF18: PureStem Z11, Meso Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF18
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TNFSF18
     SwitchGear Promoter luciferase reporter plasmids for TNFSF18
     ThermoFisher Antibodies for TNFSF18
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF18
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFSF18
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNFSF18
     LSBio Antibodies in human, mouse, rat for TNFSF18
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TNFSF18 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4