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Aliases for TNFSF18 Gene

Aliases for TNFSF18 Gene

  • Tumor Necrosis Factor Superfamily Member 18 2 3 5
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 18 2 3
  • Glucocorticoid-Induced TNF-Related Ligand 3 4
  • Activation-Inducible TNF-Related Ligand 3 4
  • HGITRL 3 4
  • AITRL 3 4
  • GITRL 3 4
  • TL6 3 4
  • Glucocorticoid-Induced TNFR-Related Protein Ligand 3
  • Tumor Necrosis Factor Ligand Superfamily Member 18 3
  • Tumor Necrosis Factor Ligand 2A 3
  • AITR Ligand 3
  • GITR Ligand 3
  • TNLG2A 3

External Ids for TNFSF18 Gene

Previous GeneCards Identifiers for TNFSF18 Gene

  • GC01M170574
  • GC01M168639
  • GC01M169591
  • GC01M170249
  • GC01M170248
  • GC01M169740
  • GC01M171275
  • GC01M144235

Summaries for TNFSF18 Gene

Entrez Gene Summary for TNFSF18 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFSF18 Gene

TNFSF18 (Tumor Necrosis Factor Superfamily Member 18) is a Protein Coding gene. Diseases associated with TNFSF18 include Kenny-Caffey Syndrome, Type 1. Among its related pathways are TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions and Immune System. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding.

UniProtKB/Swiss-Prot for TNFSF18 Gene

  • Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).

Gene Wiki entry for TNFSF18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF18 Gene

Genomics for TNFSF18 Gene

Regulatory Elements for TNFSF18 Gene

Enhancers for TNFSF18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F172913 1.4 FANTOM5 Ensembl ENCODE 13.3 +134.1 134119 6.8 JUN FEZF1 RAD21 RFX5 FOSL1 EED SMC3 PRDM10 RCOR1 ETV6 TNFSF18 ENSG00000224228 GAS5 ENSG00000224000
GH01F172902 1.7 FANTOM5 Ensembl ENCODE 12.7 +144.3 144271 9.0 CBX3 TBL1XR1 PTRF CHAMP1 ELK1 FOS ZBTB11 JUNB CEBPB CREB3 TNFSF18 ENSG00000224228 ENSG00000224000 AIMP1P2
GH01F172989 1 FANTOM5 Ensembl ENCODE 12.5 +58.4 58368 5.4 CTCF JUND BHLHE40 RAD21 ZBTB17 TNFSF18 ENSG00000224228 GAS5 ENSG00000224000
GH01F173020 0.7 Ensembl 11.6 +30.5 30462 1.0 PKNOX1 MTA2 JUNB TBX21 EP300 ETV6 MLLT1 CREM SPI1 TNFSF18 ENSG00000224228 ENSG00000224000
GH01F172858 1.4 FANTOM5 ENCODE 11.6 +191.8 191763 2.1 JUN MAX FEZF1 RAD21 RFX5 ZNF302 ZNF19 SMC3 PRDM10 FOS ENSG00000224228 TNFSF18 LOC105371618 AIMP1P2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TNFSF18 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNFSF18 Gene

Chromosome:
1
Start:
173,039,960 bp from pter
End:
173,050,963 bp from pter
Size:
11,004 bases
Orientation:
Minus strand

Genomic View for TNFSF18 Gene

Genes around TNFSF18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF18 Gene

Proteins for TNFSF18 Gene

  • Protein details for TNFSF18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNG2-TNF18_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 18
    Protein Accession:
    Q9UNG2
    Secondary Accessions:
    • A9IQG8
    • O95852
    • Q6ISV1

    Protein attributes for TNFSF18 Gene

    Size:
    199 amino acids
    Molecular mass:
    22724 Da
    Quaternary structure:
    • Homodimer (By similarity). Homotrimer.
    SequenceCaution:
    • Sequence=AAH93986.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI12033.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ89227.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36082.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW90937.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNFSF18 Gene

neXtProt entry for TNFSF18 Gene

Post-translational modifications for TNFSF18 Gene

  • Glycosylation at Asn 151 and Asn 183

Other Protein References for TNFSF18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFSF18 (GITR Ligand/TNFSF18)
  • Santa Cruz Biotechnology (SCBT) Antibodies for TNFSF18

No data available for DME Specific Peptides for TNFSF18 Gene

Domains & Families for TNFSF18 Gene

Gene Families for TNFSF18 Gene

Protein Domains for TNFSF18 Gene

Suggested Antigen Peptide Sequences for TNFSF18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UNG2

UniProtKB/Swiss-Prot:

TNF18_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF18: view

Function for TNFSF18 Gene

Molecular function for TNFSF18 Gene

GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 18,expressed in several peripheral tissues and vascular endothelial cellsl,maybe involved in interaction between activated T lymphocytes and endothelial cells
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated after stimulation by bacterial lipopolysaccharides (LPS).

Gene Ontology (GO) - Molecular Function for TNFSF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10074428
GO:0005125 cytokine activity IEA --
GO:0032813 tumor necrosis factor receptor superfamily binding ISS,IBA --
genes like me logo Genes that share ontologies with TNFSF18: view
genes like me logo Genes that share phenotypes with TNFSF18: view

Animal Models for TNFSF18 Gene

MGI Knock Outs for TNFSF18:

Animal Model Products

Inhibitory RNA Products

Clone Products

Cell Line Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TNFSF18 Gene

Localization for TNFSF18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF18 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFSF18 Gene COMPARTMENTS Subcellular localization image for TNFSF18 gene
Compartment Confidence
plasma membrane 5
extracellular 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for TNFSF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface ISS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFSF18: view

Pathways & Interactions for TNFSF18 Gene

genes like me logo Genes that share pathways with TNFSF18: view

Interacting Proteins for TNFSF18 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000385470%0d%0a9606.ENSP00000328207%0d%0a
Selected Interacting proteins: ENSP00000385470 Q9UNG2-TNF18_HUMAN for TNFSF18 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TNFSF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002309 T cell proliferation involved in immune response ISS,IBA --
GO:0002376 immune system process IEA --
GO:0002687 positive regulation of leukocyte migration IMP 23892569
GO:0007165 signal transduction TAS 10074428
genes like me logo Genes that share ontologies with TNFSF18: view

No data available for SIGNOR curated interactions for TNFSF18 Gene

Drugs & Compounds for TNFSF18 Gene

(1) Drugs for TNFSF18 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pomalidomide (CC-4047) Pharma Immunomodulator,antumor/anti-angiogenic 0

(1) ApexBio Compounds for TNFSF18 Gene

Compound Action Cas Number
Pomalidomide (CC-4047) Immunomodulator,antumor/anti-angiogenic 19171-19-8
genes like me logo Genes that share compounds with TNFSF18: view

Transcripts for TNFSF18 Gene

mRNA/cDNA for TNFSF18 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFSF18 Gene

Tumor necrosis factor (ligand) superfamily, member 18:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF18 Gene

No ASD Table

Relevant External Links for TNFSF18 Gene

GeneLoc Exon Structure for
TNFSF18
ECgene alternative splicing isoforms for
TNFSF18

Expression for TNFSF18 Gene

mRNA expression in normal human tissues for TNFSF18 Gene

mRNA differential expression in normal tissues according to GTEx for TNFSF18 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of TNFSF18 Gene:

TNFSF18

SOURCE GeneReport for Unigene cluster for TNFSF18 Gene:

Hs.248197

mRNA Expression by UniProt/SwissProt for TNFSF18 Gene:

Q9UNG2-TNF18_HUMAN
Tissue specificity: Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
genes like me logo Genes that share expression patterns with TNFSF18: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TNFSF18 Gene

Orthologs for TNFSF18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TNFSF18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFSF18 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia TNFSF18 34 35
  • 82.3 (n)
dog
(Canis familiaris)
Mammalia TNFSF18 34 35
  • 81.56 (n)
rat
(Rattus norvegicus)
Mammalia Tnfsf18 34
  • 72.35 (n)
mouse
(Mus musculus)
Mammalia Tnfsf18 34 16 35
  • 69.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TNFSF18 35
  • 32 (a)
OneToOne
Species where no ortholog for TNFSF18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF18 Gene

ENSEMBL:
Gene Tree for TNFSF18 (if available)
TreeFam:
Gene Tree for TNFSF18 (if available)

Paralogs for TNFSF18 Gene

No data available for Paralogs for TNFSF18 Gene

Variants for TNFSF18 Gene

Sequence variations from dbSNP and Humsavar for TNFSF18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10912526 -- 173,051,434(+) GTTTA(C/T)CTTAA upstream-variant-2KB
rs10912527 -- 173,051,474(+) CTTCA(A/G)TAAAC upstream-variant-2KB
rs111300822 -- 173,046,560(+) CACCA(A/C/T)GTTAT intron-variant
rs111974124 -- 173,051,188(+) CAAAC(A/G)GCAGT upstream-variant-2KB
rs112014989 -- 173,048,217(+) AGTTT(A/C)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFSF18 Gene

Variant ID Type Subtype PubMed ID
nsv831904 CNV gain+loss 17160897

Variation tolerance for TNFSF18 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFSF18 Gene

Human Gene Mutation Database (HGMD)
TNFSF18
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFSF18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF18 Gene

Disorders for TNFSF18 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TNFSF18 Gene - From: DISEASES

Disorder Aliases PubMed IDs
kenny-caffey syndrome, type 1
  • xerophthalmia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFSF18

Genetic Association Database (GAD)
TNFSF18
Human Genome Epidemiology (HuGE) Navigator
TNFSF18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFSF18
genes like me logo Genes that share disorders with TNFSF18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF18 Gene

Publications for TNFSF18 Gene

  1. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. (PMID: 10074428) Gurney A.L. … Ashkenazi A. (Curr. Biol. 1999) 2 3 4 22 64
  2. Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. (PMID: 10037686) Kwon B. … Kwon B.S. (J. Biol. Chem. 1999) 2 3 4 64
  3. Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion. (PMID: 23892569) Lacal P.M. … Nocentini G. (J. Pharmacol. Exp. Ther. 2013) 3 4 64
  4. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. (PMID: 19760754) TAPrkvist L. … Pettersson S. (Inflamm. Bowel Dis. 2010) 3 46 64
  5. Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois P.C. … van Heel D.A. (Nat. Genet. 2010) 3 46 64

Products for TNFSF18 Gene

Sources for TNFSF18 Gene

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