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TNFSF15 Gene

protein-coding   GIFtS: 64
GCID: GC09M117551

Tumor Necrosis Factor (Ligand) Superfamily, Member 15

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor (Ligand) Superfamily, Member 151 2     TNF Superfamily Ligand TL1A1 2
TNF Ligand-Related Molecule 11 2 3     Vascular Endothelial Growth Inhibitor-192A1 2
Vascular Endothelial Cell Growth Inhibitor1 2 3     TL1A2
TL12 3 5     VEGI192A2
VEGI2 3 5     Tumor Necrosis Factor Ligand Superfamily Member 152

External Ids:    HGNC: 119311   Entrez Gene: 99662   Ensembl: ENSG000001816347   OMIM: 6040525   UniProtKB: O951503   

Export aliases for TNFSF15 gene to outside databases

Previous GC identifers: GC09M108349 GC09M109283 GC09M111005 GC09M112927 GC09M114632 GC09M116591 GC09M087156


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFSF15 Gene:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This
protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression
of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy
receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce
apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus
may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Feb 2011)

GeneCards Summary for TNFSF15 Gene:
TNFSF15 (tumor necrosis factor (ligand) superfamily, member 15) is a protein-coding gene. Diseases associated with TNFSF15 include endotheliitis, and ulcerative colitis. GO annotations related to this gene include tumor necrosis factor receptor binding and receptor binding. An important paralog of this gene is FASLG.

UniProtKB/Swiss-Prot: TNF15_HUMAN, O95150
Function: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial
growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis

Gene Wiki entry for TNFSF15 (Vascular endothelial growth inhibitor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFSF15 gene promoter:
         TBP   STAT1   GATA-3   RREB-1   CUTL1   GATA-2   GATA-1   FOXC1   Nkx6-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFSF15 promoter sequence
   Search Chromatin IP Primers for TNFSF15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFSF15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q32

TNFSF15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFSF15 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M117551:  view genomic region     (about GC identifiers)

Start:
117,546,915 bp from pter      End:
117,568,408 bp from pter
Size:
21,494 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TNF15_HUMAN, O95150 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 15  
Size: 251 amino acids; 28087 Da
Subunit: Homotrimer
Selected PDB 3D structures from and Proteopedia for TNFSF15 (see all 7):
2O0O (3D)        2QE3 (3D)        2RE9 (3D)        2RJK (3D)        2RJL (3D)        3K51 (3D)    
Secondary accessions: Q3SX69 Q5VJK8 Q5VWH1 Q8NFE9
Alternative splicing: 3 isoforms:  O95150-1   O95150-2   O95150-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNFSF15: NX_O95150

Explore proteomics data for TNFSF15 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn133, Asn229

  • See TNFSF15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001191273.1  NP_005109.2  

    ENSEMBL proteins: 
     ENSP00000363157   ENSP00000363156  

    TNFSF15 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for TNFSF15
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TNFSF: Tumor necrosis factor (ligand) superfamily

    4 InterPro protein domains:
     IPR008064 TNFalpha/TNFSF15
     IPR006052 TNF_dom
     IPR006053 TNF
     IPR008983 Tumour_necrosis_fac-like_dom

    Graphical View of Domain Structure for InterPro Entry O95150

    ProtoNet protein and cluster: O95150

    1 Blocks protein domain: IPB006052 Tumor Necrosis Factor

    UniProtKB/Swiss-Prot: TNF15_HUMAN, O95150
    Similarity: Belongs to the tumor necrosis factor family


    TNFSF15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNF15_HUMAN, O95150
    Function: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial
    growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis
    Induction: Up-regulated by IL1A/interleukin-1 alpha and TNF

         Genatlas biochemistry entry for TNFSF15:
    tumor necrosis factor (ligand) superfamily,member 15,expressed in hematopoietic cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS9434163
    GO:0005123death receptor binding IEA--
    GO:0005125cytokine activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding ----
         
    TNFSF15 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TNFSF15:
     Increased cell death in breast 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tnfsf15):
     cellular  hematopoietic system  immune system 

    TNFSF15 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TNFSF15: Tnfsf15tm1Cdon Tnfsf15tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFSF15
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNFSF15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFSF15
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFSF15

    miRNA
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    miRTarBase miRNAs that target TNFSF15:
    hsa-mir-26b-5p (MIRT029860)

    Block miRNA regulation of human, mouse, rat TNFSF15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNFSF15 (see all 40):
    hsa-miR-579 hsa-miR-485-3p hsa-miR-605 hsa-miR-374c hsa-miR-183* hsa-miR-3658 hsa-miR-889 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidTNFSF15 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TNFSF15
    Predesigned siRNA for gene silencing in human, mouse, rat TNFSF15

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    GenScript: all cDNA clones in your preferred vector (see all 2): TNFSF15 (NM_005118)
    Sino Biological Human cDNA Clone for TNFSF15
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFSF15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF15

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNF15_HUMAN, O95150: Membrane; Single-pass type II membrane protein (Probable)
    TNF15_HUMAN, O95150: Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    cytoskeleton1
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane IDA11911831
    GO:0005887integral component of plasma membrane TAS9872942
    GO:0016020membrane ----
    GO:0016021integral component of membrane NAS9872942

    TNFSF15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFSF15 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2TWEAK Pathway
    DR3 Signaling0.87
    3Apoptosis and survival Anti apoptotic TNFs NF kB Bcl 2 pathway
    Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway0.46
    4PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    5Apoptosis Signaling Pathways
    Apoptosis Signaling Pathways0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for TNFSF15
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    Apoptosis Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TNFSF15
        DR3 Signaling

    1 GeneGo (Thomson Reuters) Pathway for TNFSF15
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

    1 BioSystems Pathway for TNFSF15
        Senescence and Autophagy

    3 Sino Biological Pathways for TNFSF15
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1 Kegg Pathway  (Kegg details for TNFSF15):
        Cytokine-cytokine receptor interaction


    TNFSF15 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFSF15: 
              TNF Ligands & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFSF15

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TNFSF15 (O951503 ENSP000003631574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF6BO954073, ENSP000003590134I2D: score=1 STRING: ENSP00000359013
    TNFRSF25Q930383, ENSP000003670134I2D: score=2 STRING: ENSP00000367013
    RTEL1ENSP000003533324STRING: ENSP00000353332
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IDA11911831
    GO:0006955immune response IEA--
    GO:0007165signal transduction NAS9872942
    GO:0007250activation of NF-kappaB-inducing kinase activity IDA11911831
    GO:0042107cytokine metabolic process IDA11911831

    TNFSF15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFSF15 (TNF15)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TNFSF15 gene (2 alternative transcripts): 
    NM_001204344.1  NM_005118.3  

    Unigene Cluster for TNFSF15:

    Tumor necrosis factor (ligand) superfamily, member 15
    Hs.23349  [show with all ESTs]
    Unigene Representative Sequence: NM_005118
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374045(uc004bjg.3 uc004bjh.3) ENST00000374044
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TNFSF15 (see all 40):
    hsa-miR-579 hsa-miR-485-3p hsa-miR-605 hsa-miR-374c hsa-miR-183* hsa-miR-3658 hsa-miR-889 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidTNFSF15 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat TNFSF15
      QuantiFast Probe-based Assays in human, mouse, rat TNFSF15

    Additional mRNA sequence: 

    AF520785.1 AK291642.1 AK313721.1 AY434464.1 BC069435.1 BC074940.2 BC074941.2 BC104462.1 
    BC104463.1 

    4 DOTS entries:

    DT.99997095  DT.208703  DT.91988301  DT.100701114 

    6 AceView cDNA sequences:

    NM_005118 BC074940 AF039390 BC069435 BC074941 AF520785 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFSF15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATATCAAAA
    TNFSF15 Expression
    About this image


    TNFSF15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
    TNFSF15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFSF15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.23349

    UniProtKB/Swiss-Prot: TNF15_HUMAN, O95150
    Tissue specificity: Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver,
    kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFSF15: 
              TNF Ligands & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFSF15 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfsf151 , 5 tumor necrosis factor (ligand) superfamily, member more1, 5 78.41(n)1
    67.61(a)1
      4 (34.06 cM)5
    3266231  NM_177371.31  NP_796345.31 
     637270845 
    chicken
    (Gallus gallus)
    Aves TNFSF151 tumor necrosis factor (ligand) superfamily, member more 63.92(n)
    55.83(a)
      417247  NM_001024578.1  NP_001019749.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNFSF156
    tumor necrosis factor (ligand) superfamily, member...
    30(a)
    1 ↔ 1
    GL343494.1(118344-132674)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tnfsf151 tumor necrosis factor (ligand) superfamily, member more 52.43(n)
    45.15(a)
      100494382  XM_002935201.2  XP_002935247.2 


    ENSEMBL Gene Tree for TNFSF15 (if available)
    TreeFam Gene Tree for TNFSF15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNFSF15 gene
    FASLG2  LTA2  TNFSF142  TNF2  

    TNFSF15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFSF15 (see all 487)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs559183411,2
    C--117547199(+) GAAAC-/AAAAAA 2 -- ut312Minor allele frequency- A:0.25NA 4
    rs3705066761,2
    C--117555584(+) GAGTT-/GGGGTT 2 -- int1 us2k10--------
    rs1446687771,2
    --117558468(+) TCCCGC/TGGATT 2 -- ds50010--------
    rs1474589011,2
    --117558592(+) GTTCAA/GTGTGA 2 -- ds50010--------
    rs1398312261,2
    C--117558667(+) CCTCCC/TTTTCC 2 -- ds50010--------
    rs561397661,2
    C--117558800(+) ATTAGA/CAGCAT 2 -- ds50010--------
    rs1154208201,2
    C,F--117558839(+) TTAGAC/TTTAAT 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1878977471,2
    --117558951(+) TAACAC/TATACA 2 -- ut310--------
    rs559588171,2
    C,F--117559028(+) AGTACG/ATATCC 2 -- ut311Minor allele frequency- A:0.02EA 120
    rs1918399091,2
    C--117559164(+) CCTGAA/TACAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for TNFSF15 (117546915 - 117568408 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TNFSF15:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893750CNV Loss21882294
    nsv831695CNV Gain17160897

    Human Gene Mutation Database (HGMD): TNFSF15
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFSF15
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604052    OMIM disorders: --

    19 diseases for TNFSF15:    
    About MalaCards
    endotheliitis    ulcerative colitis    primary biliary cirrhosis    crohn's disease
    ankylosing spondylitis    inflammatory bowel disease    leprosy    spondylitis
    irritable bowel syndrome    clear cell renal cell carcinoma    type 1 diabetes    hepatitis b
    rheumatoid arthritis    arthritis    ovarian cancer    renal cell carcinoma
    hepatitis    prostate cancer    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for TNFSF15:
    Crohn's disease     Ulcerative colitis

    TNFSF15 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TNFSF15 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammatory bowel diseases 47.6 9 19839006 (3), 14568967 (2), 19637197 (1), 19522538 (1) (see all 5)
    colitis ulcerative 43.6 3 19262684 (1), 14568967 (1)
    inflammation 39.1 16 19262684 (2), 15207783 (2), 18598698 (2), 18287561 (2) (see all 7)

    Genetic Association Database (GAD): TNFSF15
    Human Genome Epidemiology (HuGE) Navigator: TNFSF15 (22 documents)

    Export disorders for TNFSF15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFSF15 gene, integrated from 10 sources (see all 97):
    (articles sorted by number of sources associating them with TNFSF15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells. (PubMed id 9434163)1, 2, 3 Tan K.B.... Truneh A. (Gene 1997)
    2. IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein. (PubMed id 19262684)1, 4, 9 Michelsen K.S....Targan S.R. (PLoS ONE 2009)
    3. TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. (PubMed id 11911831)1, 2, 9 Migone T.-S....Wei P. (Immunity 2002)
    4. HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease. (PubMed id 21699788)1, 4 Okada Y....Kubo M. (Gastroenterology 2011)
    5. Decoy strategies: the structure of TL1A:DcR3 complex. (PubMed id 21300286)1, 2 Zhan C.... Almo S.C. (Structure 2011)
    6. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
    7. Genetic predictors of medically refractory ulcerative colitis. (PubMed id 20848476)1, 4 Haritunians T....McGovern D.P. (Inflamm. Bowel Dis. 2010)
    8. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. (PubMed id 19760754)1, 4 TAPrkvist L....Pettersson S. (Inflamm. Bowel Dis. 2010)
    9. Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children. (PubMed id 20473688)1, 4 Amre D.K....Levy E. (Hum. Genet. 2010)
    10. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. (PubMed id 20176734)1, 4 Wang K....Hakonarson H. (Hum. Mol. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9966 HGNC: 11931 AceView: TNFSF15 Ensembl:ENSG00000181634 euGenes: HUgn9966
    ECgene: TNFSF15 Kegg: 9966 H-InvDB: TNFSF15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TNFSF15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFSF15 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TNFSF15 gene:
    Search GeneIP for patents involving TNFSF15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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