TNFSF15 Gene

Aliases
for TNFSF15 gene

Previous GC identifers: GC09M108349 GC09M109283 GC09M111005 GC09M112927 GC09M114632 GC09M116591 GC09M087156

Summaries
for TNFSF15 gene

Genomic Views
for TNFSF15 gene

RefSeq DNA sequence:

NC_000009.11  NC_018920.1  NT_008470.19  

SwitchGear Promoter luciferase reporter plasmid: TNFSF15 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFSF15

TNFSF15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M117551:  view genomic region     (about GC identifiers)

Proteins
for TNFSF15 gene

6/7 PDB 3D structures from and Proteopedia for TNFSF15 (see all 7):

2O0O (3D)        2QE3 (3D)        2RE9 (3D)        2RJK (3D)        2RJL (3D)        3K51 (3D)    

Explore the universe of human proteins at neXtProt for TNFSF15: NX_O95150

TNFSF15 Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for TNFSF15 (TL1A/TNFSF15)
	Enzo Life Sciences proteins for TNFSF15
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TNFSF15 OriGene Custom Protein Services for TNFSF15
	GenScript Purified and Recombinant Proteins for TNFSF15
	Novus Biologicals TNFSF15 Proteins Novus Biologicals TNFSF15 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for TNFSF15
	Uscn Proteins for TNFSF15

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for TNFSF15 (TL1A/TNFSF15)
	Browse OriGene Antibodies OriGene Custom Antibody Services for TNFSF15
	GenScript Custom Superior Antibodies Services for TNFSF15
	Novus Biologicals TNFSF15 Antibodies
	Abcam antibodies for TNFSF15
	Uscn Antibodies for TNFSF15
	ThermoFisher Antibodies for TNFSF15

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TNFSF15
	Enzo Life Sciences assays for TNFSF15
	Uscn ELISAs and CLIAs for TNFSF15

Protein Domains /
Families
for TNFSF15 gene

ProtoNet protein and cluster: O95150

Function
for TNFSF15 gene

miRNA Products:		OriGene 3'-UTR Clone: TNFSF15 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFSF15
		8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFSF15 (see all 40):
		hsa-miR-579 hsa-miR-485-3p hsa-miR-605 hsa-miR-374c hsa-miR-183* hsa-miR-3658 hsa-miR-889 hsa-miR-330-3p
		SwitchGear 3'UTR luciferase reporter plasmid: TNFSF15 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFSF15 (see all 7) OriGene shRNA RFP: TNFSF15 OriGene siRNA: TNFSF15
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFSF15

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TNFSF15

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF15 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF15 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TNFSF15 (NM_005118)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFSF15
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF15

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TNFSF15
		Search LifeMap BioReagents cell lines for TNFSF15

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF15

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Tnfsf15)

Pathways & Interactions
for TNFSF15 gene

	Super-pathway	contained gene-specific pathways
1	Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway 0.46 Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway 0.46
2	Senescence and Autophagy	Senescence and Autophagy 1.00
3	TWEAK Pathway	DR3 Signaling 0.87
4	Apoptosis and survival_Apoptotic TNF-family pathways	Apoptosis Signaling Pathways 0.35
5	PEDF Induced Signaling	Cytokine-cytokine receptor interaction 0.26

1 EMD Millipore Pathway for TNFSF15

Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

2 R&D Systems Pathways for TNFSF15

	TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
	Apoptosis Signaling Pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TNFSF15

DR3 Signaling

1 GeneGo (Thomson Reuters) Pathway for TNFSF15

Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

1 BioSystems Pathway for TNFSF15

Senescence and Autophagy

1         Kegg Pathway  (Kegg details for TNFSF15)

Cytokine-cytokine receptor interaction

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

Drugs & Compounds
for TNFSF15 gene

Transcripts
for TNFSF15 gene

Expression
for TNFSF15 gene

TNFSF15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATATCAAAA

Stem Cell Differentiation: 3 LifeMap Cells
	Name			Category
	Human umbilical vein endothelial cells (HUVEC) (Primary Cell)			Endothelium
	Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
	CD31, CD144 positive cells (Two-step protocol fo...)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFSF15 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNFSF15
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFSF15
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFSF15

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF15

Orthologs
for TNFSF15 gene

Paralogs
for TNFSF15 gene

Paralogs for TNFSF15 gene

FASLG²  LTA²  TNFSF14²  TNF²  

TNFSF15 for paralogs           About GeneDecksing

Genomic Variants
for TNFSF15 gene

10/391 NCBI SNPs in TNFSF15 are shown (see all 391)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs561397661,2	C,	--	87151441(+)	ATTAGA/CAGCAT	2	--	ds5001		0	--	--	--	--
rs559588171,2	C,F,	--	87151669(+)	AGTACG/ATATCC	2	--	ut31		1		EA	120
rs562066221,2	C	--	87151824(+)	ACATTG/ACATGC	2	--	ut31		1		NA	2
rs109824081,2	H	--	87151870(+)	TTCAGC/ATACTT	2	--	ut31		4		NS EA	418
rs70246611,2	C,	--	87153596(+)	gagatC/Tgagac	2	--	ut31		0	--	--	--	--
rs344271611,2	C	--	87153800(+)	GTCTC-/AAAAAA	2	--	ut31		0	--	--	--	--
rs561271091,2	C,	--	87153845(+)	CATAAG/TCAATT	2	--	ut31		0	--	--	--	--
rs78532871,2	C,F,H,	--	87153935(+)	TTGCTG/AAGGAA	2	--	ut31		13		NS EA NA WA CSA	806
rs78716091,2	C,F,H,	--	87154043(+)	CTACAT/CGTAGT	2	--	ut31		5		NS EA WA	418
rs785146131,2		--	87155115(+)	TTAAGT/CCAAGG	2	--	ut31		1		WA	118

HapMap Linkage Disequilibrium report for TNFSF15 (117551600 - 117568408 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for TNFSF15: --
Human Gene Mutation Database (HGMD): TNFSF15

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFSF15

DNA2.0 Custom Variant and Variant Library Synthesis for TNFSF15

Disorders / Diseases
for TNFSF15 gene

14 diseases for TNFSF15

3 Novoseek disease relationships for TNFSF15 gene    About this table

Publications
for TNFSF15 gene

PubMed articles for TNFSF15 gene, integrated from 9 sources (see all 86): (articles sorted by number of sources associating them with TNFSF15)

Utopia: connect your pdf to the dynamic world of online information

1. Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells. (PubMed id 9434163)^{1, 2, 3} Tan K.B....Truneh A. (1997)
2. TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. (PubMed id 11911831)^{1, 2, 9} Migone T.-S....Wei P. (2002)
3. Decoy strategies: the structure of TL1A:DcR3 complex. (PubMed id 21300286)^{1, 2} Zhan C.... Almo S.C. (2011)
4. X-ray crystal structure of TNF ligand family member TL1A at 2.1A. (PubMed id 17935696)^{1, 2} Jin T.... Zhang Y.-Z. (2007)
5. Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. (PubMed id 16221758)^{1, 4} Yamazaki K....Nakamura Y. (2005)
6. A novel secreted splice variant of vascular endothelial cell growth inhibitor. (PubMed id 11923219)^{1, 2} Chew L.J....Li L.Y. (2002)
7. VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo. (PubMed id 9872942)^{1, 2} Zhai Y.... Yu G.-L. (1999)
8. VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth. (PubMed id 10597252)^{1, 2} Haridas V.... Aggarwal B.B. (1999)
9. IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein. (PubMed id 19262684)^{1, 9} Michelsen K.S....Targan S.R. (2009)
10. Involvement of NF-kappa B pathway in TL1A gene expres sion induced by lipopolysaccharide. (PubMed id 19815424)^{1, 9} Endo K....Shimosegawa T. (2010)

External Searches for TNFSF15 gene

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Products
for TNFSF15 gene