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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFSF15 Gene

protein-coding   GIFtS: 63
GCID: GC09M117551

Tumor Necrosis Factor (Ligand) Superfamily, Member 15

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Necrosis Factor (Ligand) Superfamily, Member 151 2     TNF Superfamily Ligand TL1A1 2
TNF Ligand-Related Molecule 11 2 3     Vascular Endothelial Growth Inhibitor-192A1 2
Vascular Endothelial Cell Growth Inhibitor1 2 3     TL1A2
TL12 3 5     VEGI192A2
VEGI2 3 5     Tumor Necrosis Factor Ligand Superfamily Member 152

External Ids:    HGNC: 119311   Entrez Gene: 99662   Ensembl: ENSG000001816347   OMIM: 6040525   UniProtKB: O951503   

Export aliases for TNFSF15 gene to outside databases

Previous GC identifers: GC09M108349 GC09M109283 GC09M111005 GC09M112927 GC09M114632 GC09M116591 GC09M087156


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFSF15 Gene:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This
protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression
of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy
receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce
apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus
may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Feb 2011)

GeneCards Summary for TNFSF15 Gene: 
TNFSF15 (tumor necrosis factor (ligand) superfamily, member 15) is a protein-coding gene. Diseases associated with TNFSF15 include endotheliitis, and ulcerative colitis, and among its related super-pathways are TNF Signaling and TWEAK Pathway. GO annotations related to this gene include tumor necrosis factor receptor binding and receptor binding. An important paralog of this gene is FASLG.

UniProtKB/Swiss-Prot: TNF15_HUMAN, O95150
Function: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial
growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis

Gene Wiki entry for TNFSF15 (Vascular endothelial growth inhibitor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFSF15 gene promoter:
         TBP   STAT1   GATA-3   RREB-1   CUTL1   GATA-2   GATA-1   FOXC1   Nkx6-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFSF15 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFSF15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFSF15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q32

TNFSF15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFSF15 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M117551:  view genomic region     (about GC identifiers)

Start:
117,546,915 bp from pter      End:
117,568,408 bp from pter
Size:
21,494 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNF15_HUMAN, O95150 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 15  
Size: 251 amino acids; 28087 Da
Subunit: Homotrimer
Subcellular location: Membrane; Single-pass type II membrane protein (Probable)
Subcellular location: Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted
6/7 PDB 3D structures from and Proteopedia for TNFSF15 (see all 7):
2O0O (3D)        2QE3 (3D)        2RE9 (3D)        2RJK (3D)        2RJL (3D)        3K51 (3D)    
Secondary accessions: Q3SX69 Q5VJK8 Q5VWH1 Q8NFE9
Alternative splicing: 3 isoforms:  O95150-1   O95150-2   O95150-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNFSF15: NX_O95150

Explore proteomics data for TNFSF15 at MOPED 

TNFSF15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TNFSF15 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001191273.1  NP_005109.2  

ENSEMBL proteins: 
 ENSP00000363157   ENSP00000363156  

Human Recombinant Protein Products for TNFSF15: 
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Sino Biological Recombinant Protein for TNFSF15
Sino Biological Cell Lysate for TNFSF15 
ProSpec Recombinant Protein for TNFSF15
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--
GO:0005886plasma membrane IDA11911831
GO:0005887integral to plasma membrane TAS9872942
GO:0016020membrane ----
GO:0016021integral to membrane NAS9872942

TNFSF15 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TNFSF: Tumor necrosis factor (ligand) superfamily

3 InterPro protein domains:
 IPR006052 TNF
 IPR006053 TNF_a/b/c
 IPR008983 Tumour_necrosis_fac-like_dom

Graphical View of Domain Structure for InterPro Entry O95150

ProtoNet protein and cluster: O95150

1 Blocks protein domain: IPB006052 Tumor Necrosis Factor

UniProtKB/Swiss-Prot: TNF15_HUMAN, O95150
Similarity: Belongs to the tumor necrosis factor family


TNFSF15 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TNF15_HUMAN, O95150
Function: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial
growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis
Induction: Up-regulated by IL1A/interleukin-1 alpha and TNF

     Genatlas biochemistry entry for TNFSF15:
tumor necrosis factor (ligand) superfamily,member 15,expressed in hematopoietic cells

     Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding TAS9434163
GO:0005123death receptor binding IEA--
GO:0005125cytokine activity IEA--
GO:0005164tumor necrosis factor receptor binding IEA--
GO:0005515protein binding ----
     
TNFSF15 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for TNFSF15:
 Increased cell death in breast 

     3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tnfsf15):
 cellular  hematopoietic system  immune system 

TNFSF15 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for TNFSF15: Tnfsf15tm1Cdon Tnfsf15tm1Lex

   inGenious Targeting Laboratory - Custom generated mouse model solutions for TNFSF15 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNFSF15

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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFSF15 

miRNA
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hsa-miR-579 hsa-miR-485-3p hsa-miR-605 hsa-miR-374c hsa-miR-183* hsa-miR-3658 hsa-miR-889 hsa-miR-330-3p
SwitchGear 3'UTR luciferase reporter plasmidTNFSF15 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF15


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TNFSF15 About   (see all 6)                                                                                              See pathways by source

SuperPathContained pathways About
1TNF Signaling
TNF Signaling0.50
TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.49
Death Receptor Signaling0.50
NF-kB (NFkB) Pathway0.46
2TWEAK Pathway
DR3 Signaling0.87
3Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway0.46
4PEDF Induced Signaling
Cytokine-cytokine receptor interaction0.43
5Apoptosis and survival Apoptotic TNF-family pathways
Apoptosis Signaling Pathways0.35

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for TNFSF15
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

2 R&D Systems Pathways for TNFSF15
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
Apoptosis Signaling Pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TNFSF15
    DR3 Signaling

1 GeneGo (Thomson Reuters) Pathway for TNFSF15
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

1 BioSystems Pathway for TNFSF15
    Senescence and Autophagy

3 Sino Biological Pathways for TNFSF15 
    TNF Signaling
Death Receptor Signaling
NF-kB (NFkB) Pathway


1         Kegg Pathway  (Kegg details for TNFSF15):
    Cytokine-cytokine receptor interaction


TNFSF15 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFSF15

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for TNFSF15 (O951503 ENSP000003631574) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TNFRSF6BO954073, ENSP000003590134I2D: score=1 STRING: ENSP00000359013
TNFRSF25Q930383, ENSP000003670134I2D: score=2 STRING: ENSP00000367013
RTEL1ENSP000003533324STRING: ENSP00000353332
About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IDA11911831
GO:0006955immune response IEA--
GO:0007165signal transduction NAS9872942
GO:0007250activation of NF-kappaB-inducing kinase activity IDA11911831
GO:0042107cytokine metabolic process IDA11911831

TNFSF15 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNFSF15 (TNF15)

Search CenterWatch for drugs/clinical trials and news about TNFSF15 / TNF15

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNFSF15 gene (2 alternative transcripts): 
NM_001204344.1  NM_005118.3  

Unigene Cluster for TNFSF15:

Tumor necrosis factor (ligand) superfamily, member 15
Hs.23349  [show with all ESTs]
Unigene Representative Sequence: NM_005118
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000374045(uc004bjg.3 uc004bjh.3) ENST00000374044
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFSF15 (see all 40):
hsa-miR-579 hsa-miR-485-3p hsa-miR-605 hsa-miR-374c hsa-miR-183* hsa-miR-3658 hsa-miR-889 hsa-miR-330-3p
SwitchGear 3'UTR luciferase reporter plasmidTNFSF15 3' UTR sequence
Inhib. RNA
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Clone
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GenScript: all cDNA clones in your preferred vector (see all 2): TNFSF15 (NM_005118)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFSF15
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF15
Sirion Biotech Customized lentivirus for stable overexpression of TNFSF15 
                     Customized lentivirus expression plasmids for stable overexpression of TNFSF15 
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFSF15

Additional mRNA sequence: 

AF520785.1 AK291642.1 AK313721.1 AY434464.1 BC069435.1 BC074940.2 BC074941.2 BC104462.1 
BC104463.1 

4 DOTS entries:

DT.99997095  DT.208703  DT.91988301  DT.100701114 

6 AceView cDNA sequences:

NM_005118 BC074940 BC069435 BC074941 AF039390 AF520785 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNFSF15 expression in normal human tissues (normalized intensities)      TNFSF15 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TATATCAAAA
TNFSF15 Expression
About this image


TNFSF15 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Endothelium (Cardiovascular System)    fully expand to see all 3 entries
         Human umbilical vein endothelial cells (HUVEC)
         CD31, CD144 positive cells ( Two-step protocol for endothelial differentiation by...
         cd31+ cells   
 
 Pancreas (Endocrine System)
         Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
 
 Uterus (Reproductive System)
         endometrial endothelial cell   
 
 Blood (Cardiovascular System)
         cd31+ cells   
 
 Cartilage (Muscoskeletal System)
         fetal cartilage   

See TNFSF15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFSF15

SOURCE GeneReport for Unigene cluster: Hs.23349

UniProtKB/Swiss-Prot: TNF15_HUMAN, O95150
Tissue specificity: Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver,
kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon

    SABiosciences Expression via Pathway-Focused PCR Arrays including TNFSF15: 
          TNF Ligands & Receptors in human mouse rat
          Common Cytokines in human mouse rat
          Apoptosis 384HT in human mouse rat
          Necrosis in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFSF15
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF15

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF15 gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tnfsf151 , 5 tumor necrosis factor (ligand) superfamily, member more1, 5 78.41(n)1
67.61(a)1
  4 (34.06 cM)5
3266231  NM_177371.31  NP_796345.31 
 637270845 
chicken
(Gallus gallus)
Aves TNFSF151 tumor necrosis factor (ligand) superfamily, member more 61.86(n)
54.33(a)
  417247  NM_001024578.1  NP_001019749.1 
lizard
(Anolis carolinensis)
Reptilia TNFSF156
tumor necrosis factor (ligand) superfamily, member...
25(a)
1 ↔ 1
GL343494.1(118344-132674)


ENSEMBL Gene Tree for TNFSF15 (if available)
TreeFam Gene Tree for TNFSF15 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TNFSF15 gene
FASLG2  LTA2  TNFSF142  TNF2  

TNFSF15 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/487 SNPs in TNFSF15 are shown (see all 487)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs559183411,2
C--117547199(+) GAAAC-/AAAAAA 2 -- ut312Minor allele frequency- A:0.25NA 4
rs3705066761,2
C--117555584(+) GAGTT-/GGGGTT 2 -- int1 us2k10--------
rs1446687771,2
--117558468(+) TCCCGC/TGGATT 2 -- ds50010--------
rs1474589011,2
--117558592(+) GTTCAA/GTGTGA 2 -- ds50010--------
rs1398312261,2
C--117558667(+) CCTCCC/TTTTCC 2 -- ds50010--------
rs561397661,2
C--117558800(+) ATTAGA/CAGCAT 2 -- ds50010--------
rs1154208201,2
C,F--117558839(+) TTAGAC/TTTAAT 2 -- ds50011Minor allele frequency- T:0.01WA 118
rs1878977471,2
--117558951(+) TAACAC/TATACA 2 -- ut310--------
rs559588171,2
C,F--117559028(+) AGTACG/ATATCC 2 -- ut311Minor allele frequency- A:0.02EA 120
rs1918399091,2
C--117559164(+) CCTGAA/TACAAA 2 -- ut310--------

HapMap Linkage Disequilibrium report for TNFSF15 (117546915 - 117568408 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for TNFSF15:    About this table     
Variant IDTypeSubtypePubMed ID
nsv893750CNV Loss21882294
nsv831695CNV Gain17160897


Human Gene Mutation Database (HGMD): TNFSF15
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604052    OMIM disorders: --

15 diseases for TNFSF15:    About MalaCards
endotheliitis    ulcerative colitis    inflammatory bowel disease    crohn's disease
ankylosing spondylitis    leprosy    spondylitis    type 1 diabetes
hepatitis b    rheumatoid arthritis    arthritis    hepatitis
prostate cancer    prostatitis    ovarian cancer

2 diseases from the University of Copenhagen DISEASES database for TNFSF15:
Crohn's disease     Ulcerative colitis

TNFSF15 for disorders           About GeneDecksing

3 Novoseek inferred disease relationships for TNFSF15 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
inflammatory bowel diseases 47.6 9 19839006 (3), 14568967 (2), 19637197 (1), 19522538 (1) (see all 5)
colitis ulcerative 43.6 3 19262684 (1), 14568967 (1)
inflammation 39.1 16 19262684 (2), 15207783 (2), 18598698 (2), 18287561 (2) (see all 7)

Genetic Association Database (GAD): TNFSF15
Human Genome Epidemiology (HuGE) Navigator: TNFSF15 (22 documents)

Export disorders for TNFSF15 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TNFSF15 gene, integrated from 9 sources (see all 94):
(articles sorted by number of sources associating them with TNFSF15)
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world of online information

  1. Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells. (PubMed id 9434163)1, 2, 3 Tan K.B....Truneh A. (1997)
  2. IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein. (PubMed id 19262684)1, 4, 9 Michelsen K.S....Targan S.R. (2009)
  3. TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. (PubMed id 11911831)1, 2, 9 Migone T.-S....Wei P. (2002)
  4. HLA-Cw*1202-B*5201-DRB1*1502 Haplotype Increases Risk for Ulcerative Colitis but Reduces Risk for Crohn's Disease. (PubMed id 21699788)1, 4 Okada Y....Kubo M. (2011)
  5. Decoy strategies: the structure of TL1A:DcR3 complex. (PubMed id 21300286)1, 2 Zhan C.... Almo S.C. (2011)
  6. Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (2011)
  7. Genetic predictors of medically refractory ulcerative colitis. (PubMed id 20848476)1, 4 Haritunians T....McGovern D.P. (2010)
  8. Analysis of 39 Crohn's disease risk loci in Swedish i nflammatory bowel disease patients. (PubMed id 19760754)1, 4 TAPrkvist L....Pettersson S. (2010)
  9. Association between genome-wide association studies r eported SNPs and pediatric-onset Crohn's disease in Canadian children. (PubMed id 20473688)1, 4 Amre D.K....Levy E. (2010)
  10. Comparative genetic analysis of inflammatory bowel di sease and type 1 diabetes implicates multiple loci with opposite effects. (PubMed id 20176734)1, 4 Wang K....Hakonarson H. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9966 HGNC: 11931 AceView: TNFSF15 Ensembl:ENSG00000181634 euGenes: HUgn9966
ECgene: TNFSF15 Kegg: 9966 H-InvDB: TNFSF15

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TNFSF15 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFSF15 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TNFSF15 gene:
Search GeneIP for patents involving TNFSF15

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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