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Aliases for TNFSF14 Gene

Aliases for TNFSF14 Gene

  • TNF Superfamily Member 14 2 3
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 14 2 3
  • Tumor Necrosis Factor Superfamily Member 14 3 5
  • Herpesvirus Entry Mediator Ligand 3 4
  • HVEML 3 4
  • LIGHT 3 4
  • Tumor Necrosis Factor Ligand Superfamily Member 14 3
  • Herpes Virus Entry Mediator Ligand 4
  • Tumor Necrosis Factor Ligand 1D 3
  • CD258 Antigen 4
  • HVEM-L 4
  • CD258 3
  • LTg 3

External Ids for TNFSF14 Gene

Previous GeneCards Identifiers for TNFSF14 Gene

  • GC19M006759
  • GC19M006604
  • GC19M006615
  • GC19M006425

Summaries for TNFSF14 Gene

Entrez Gene Summary for TNFSF14 Gene

  • The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFSF14 Gene

TNFSF14 (TNF Superfamily Member 14) is a Protein Coding gene. Diseases associated with TNFSF14 include Herpes Simplex. Among its related pathways are TRAF Pathway and Innate Immune System. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF15.

UniProtKB/Swiss-Prot for TNFSF14 Gene

  • Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.

Gene Wiki entry for TNFSF14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF14 Gene

Genomics for TNFSF14 Gene

Regulatory Elements for TNFSF14 Gene

Enhancers for TNFSF14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G006674 1.9 FANTOM5 Ensembl ENCODE dbSUPER 51.5 -4.5 -4519 1.1 HDGF PKNOX1 CREB3L1 YBX1 ELK1 ZNF143 ZNF207 FOS ZNF548 KDM4B TNFSF14 C3 GPR108 TRIP10 XAB2 ZNF557 ADGRE1 VAV1 TNFSF9 DENND1C
GH19G006639 1.4 FANTOM5 ENCODE dbSUPER 21.9 +31.0 31031 0.7 HDAC1 PKNOX1 ATF1 GATA2 ZNF366 FOS CREM JUNB ZEB2 SMARCA4 TNFSF14 TNFSF9 GC19P006639 GC19M006661
GH19G006575 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +92.1 92142 5.5 HDGF PKNOX1 ARNT WRNIP1 TCF12 GATA2 ZNF207 FOS CAVIN1 JUNB TNFSF14 TNFSF9 CD70 DENND1C ZNF557 GC19P006580 ENSG00000199223 GC19M006573
GH19G006717 1.6 Ensembl ENCODE dbSUPER 12.8 -50.6 -50571 6.4 HDGF PKNOX1 MLX ZFP64 ARID4B DMAP1 YBX1 ZNF2 YY1 SLC30A9 ENSG00000267571 XAB2 GPR108 TNFSF14 ZNF557 ENSG00000276980 C3
GH19G006641 1.3 Ensembl ENCODE dbSUPER 13.4 +28.6 28640 1.2 HDGF TBL1XR1 EBF1 RELA EED RELB ETV6 IKZF2 CREM SRF TNFSF14 GTF2F1 GC19P006639 GC19M006661
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFSF14 on UCSC Golden Path with GeneCards custom track

Promoters for TNFSF14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106564 888 201 HDGF SMAD5 NR2F1 MAX DPF2 SSRP1 POLR2A MLLT1 HNRNPL RBFOX2

Transcription factor binding sites by QIAGEN in the TNFSF14 gene promoter:

Genomic Location for TNFSF14 Gene

Chromosome:
19
Start:
6,658,135 bp from pter
End:
6,670,588 bp from pter
Size:
12,454 bases
Orientation:
Minus strand

Genomic View for TNFSF14 Gene

Genes around TNFSF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF14 Gene

Proteins for TNFSF14 Gene

  • Protein details for TNFSF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43557-TNF14_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 14
    Protein Accession:
    O43557
    Secondary Accessions:
    • A8K7M2
    • C9J5H4
    • O75476
    • Q6FHA1
    • Q8WVF8
    • Q96LD2

    Protein attributes for TNFSF14 Gene

    Size:
    240 amino acids
    Molecular mass:
    26350 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for TNFSF14 Gene

    Alternative splice isoforms for TNFSF14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFSF14 Gene

Post-translational modifications for TNFSF14 Gene

Other Protein References for TNFSF14 Gene

Antibody Products

  • R&D Systems Antibodies for TNFSF14 (LIGHT/TNFSF14)
  • Cloud-Clone Corp. Antibodies for TNFSF14
  • Santa Cruz Biotechnology (SCBT) Antibodies for TNFSF14

Assay Products

  • Enzo Life Sciences assays for TNFSF14
  • Cloud-Clone Corp Assay Kits for TNFSF14

No data available for DME Specific Peptides for TNFSF14 Gene

Domains & Families for TNFSF14 Gene

Gene Families for TNFSF14 Gene

Suggested Antigen Peptide Sequences for TNFSF14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43557

UniProtKB/Swiss-Prot:

TNF14_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF14: view

Function for TNFSF14 Gene

Molecular function for TNFSF14 Gene

GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 14,highly expressed in splenocytes,activated PBL,CD8+ tumor infiltrating lymphocytes,granulocytes,monocytes,inducing apoptosis
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
UniProtKB/Swiss-Prot Induction:
Up-regulated after T-cell activation.

Gene Ontology (GO) - Molecular Function for TNFSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 12393901
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 9462508
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA 12393901
genes like me logo Genes that share ontologies with TNFSF14: view
genes like me logo Genes that share phenotypes with TNFSF14: view

Animal Models for TNFSF14 Gene

MGI Knock Outs for TNFSF14:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFSF14 Gene

Localization for TNFSF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF14 Gene

Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein.
Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF14 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TNFSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFSF14: view

Pathways & Interactions for TNFSF14 Gene

genes like me logo Genes that share pathways with TNFSF14: view

SIGNOR curated interactions for TNFSF14 Gene

Activates:

Gene Ontology (GO) - Biological Process for TNFSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 10799510
GO:0006955 immune response IEA --
GO:0007165 signal transduction NAS 12393901
GO:0008588 release of cytoplasmic sequestered NF-kappaB IDA 12393901
GO:0010820 positive regulation of T cell chemotaxis IEA --
genes like me logo Genes that share ontologies with TNFSF14: view

Drugs & Compounds for TNFSF14 Gene

(1) Drugs for TNFSF14 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BAMINERCEPT Pharma 0

(1) Additional Compounds for TNFSF14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFSF14: view

Transcripts for TNFSF14 Gene

mRNA/cDNA for TNFSF14 Gene

Unigene Clusters for TNFSF14 Gene

Tumor necrosis factor (ligand) superfamily, member 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF14 Gene

No ASD Table

Relevant External Links for TNFSF14 Gene

GeneLoc Exon Structure for
TNFSF14
ECgene alternative splicing isoforms for
TNFSF14

Expression for TNFSF14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFSF14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFSF14 Gene

This gene is overexpressed in Liver (x19.4) and Whole Blood (x11.9).

Protein differential expression in normal tissues from HIPED for TNFSF14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (51.0), CD8 Tcells (7.3), and NK cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFSF14 Gene



Protein tissue co-expression partners for TNFSF14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNFSF14 Gene:

TNFSF14

SOURCE GeneReport for Unigene cluster for TNFSF14 Gene:

Hs.129708

mRNA Expression by UniProt/SwissProt for TNFSF14 Gene:

O43557-TNF14_HUMAN
Tissue specificity: Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.

Evidence on tissue expression from TISSUES for TNFSF14 Gene

  • Spleen(4.3)
  • Liver(4.2)
  • Blood(2)
genes like me logo Genes that share expression patterns with TNFSF14: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF14 Gene

Orthologs for TNFSF14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFSF14 34 35
  • 98.61 (n)
dog
(Canis familiaris)
Mammalia TNFSF14 34 35
  • 82.91 (n)
cow
(Bos Taurus)
Mammalia TNFSF14 34 35
  • 78.86 (n)
rat
(Rattus norvegicus)
Mammalia Tnfsf14 34
  • 77.54 (n)
mouse
(Mus musculus)
Mammalia Tnfsf14 34 16 35
  • 76.98 (n)
oppossum
(Monodelphis domestica)
Mammalia TNFSF14 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFSF14 35
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFSF14 35
  • 42 (a)
OneToOne
Species where no ortholog for TNFSF14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF14 Gene

ENSEMBL:
Gene Tree for TNFSF14 (if available)
TreeFam:
Gene Tree for TNFSF14 (if available)

Paralogs for TNFSF14 Gene

Paralogs for TNFSF14 Gene

genes like me logo Genes that share paralogs with TNFSF14: view

Variants for TNFSF14 Gene

Sequence variations from dbSNP and Humsavar for TNFSF14 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000287634 -- 6,668,514(+) AAGTC(G/T)GGCCA intron-variant
rs1000416241 -- 6,661,795(+) ATACT(A/G)CTAAC intron-variant, utr-variant-3-prime
rs1000489886 -- 6,662,014(+) ACTGG(C/G)GCTCA intron-variant, utr-variant-3-prime
rs1000528303 -- 6,672,333(+) ACAGA(A/G)AGATA upstream-variant-2KB
rs1000855338 -- 6,666,552(+) GAAAG(C/T)GTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFSF14 Gene

Variant ID Type Subtype PubMed ID
nsv1134749 CNV deletion 24896259
nsv833728 CNV loss 17160897

Variation tolerance for TNFSF14 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFSF14 Gene

Human Gene Mutation Database (HGMD)
TNFSF14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFSF14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF14 Gene

Disorders for TNFSF14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TNFSF14 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFSF14

Genetic Association Database (GAD)
TNFSF14
Human Genome Epidemiology (HuGE) Navigator
TNFSF14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFSF14
genes like me logo Genes that share disorders with TNFSF14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF14 Gene

Publications for TNFSF14 Gene

  1. Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis. (PMID: 11673523) Granger S.W. … Ware C.F. (J. Immunol. 2001) 3 4 22 64
  2. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. (PMID: 9462508) Mauri D.N. … Ware C.F. (Immunity 1998) 2 3 4 64
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 46 64
  4. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee K.M. … Lan Q. (Am. J. Hematol. 2010) 3 46 64
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64

Products for TNFSF14 Gene

Sources for TNFSF14 Gene

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