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Aliases for TNFSF14 Gene

Aliases for TNFSF14 Gene

  • Tumor Necrosis Factor (Ligand) Superfamily, Member 14 2 3
  • HVEML 3 4 6
  • Herpes Virus Entry Mediator Ligand 3 4
  • Herpesvirus Entry Mediator Ligand 3 4
  • LIGHT 3 4
  • Tumor Necrosis Factor Ligand Superfamily Member 14 3
  • Tumor Necrosis Factor Superfamily Member LIGHT 3
  • Ligand For Herpesvirus Entry Mediator 3
  • Tumor Necrosis Factor Receptor-Like 2 3
  • Herpesvirus Entry Mediator-Ligand 3
  • Herpesvirus Entry Mediator A 3
  • Delta Transmembrane LIGHT 3
  • CD258 Antigen 4
  • HVEM-L 4
  • CD258 3
  • TR2 3
  • LTg 3

External Ids for TNFSF14 Gene

Summaries for TNFSF14 Gene

Entrez Gene Summary for TNFSF14 Gene

  • The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFSF14 Gene

TNFSF14 (Tumor Necrosis Factor (Ligand) Superfamily, Member 14) is a Protein Coding gene. Diseases associated with TNFSF14 include vascular dementia. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNF.

UniProtKB/Swiss-Prot for TNFSF14 Gene

  • Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus

Gene Wiki entry for TNFSF14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF14 Gene

Genomics for TNFSF14 Gene

Genomic Location for TNFSF14 Gene

Start:
6,661,253 bp from pter
End:
6,670,588 bp from pter
Size:
9,336 bases
Orientation:
Minus strand

Genomic View for TNFSF14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFSF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF14 Gene

Regulatory Elements for TNFSF14 Gene

Transcription factor binding sites by QIAGEN in the TNFSF14 gene promoter:

Proteins for TNFSF14 Gene

  • Protein details for TNFSF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43557-TNF14_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 14
    Protein Accession:
    O43557
    Secondary Accessions:
    • A8K7M2
    • C9J5H4
    • O75476
    • Q6FHA1
    • Q8WVF8
    • Q96LD2

    Protein attributes for TNFSF14 Gene

    Size:
    240 amino acids
    Molecular mass:
    26350 Da
    Quaternary structure:
    • Homotrimer

    Three dimensional structures from OCA and Proteopedia for TNFSF14 Gene

    Alternative splice isoforms for TNFSF14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFSF14 Gene

Proteomics data for TNFSF14 Gene at MOPED

Post-translational modifications for TNFSF14 Gene

Other Protein References for TNFSF14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFSF14 Gene

Domains for TNFSF14 Gene

Gene Families for TNFSF14 Gene

HGNC:
  • CD :CD molecules
  • TNFSF :Tumor necrosis factor (ligand) superfamily

UniProtKB/Swiss-Prot:

TNF14_HUMAN
Family:
  • Belongs to the tumor necrosis factor family.:
    • O43557
genes like me logo Genes that share domains with TNFSF14: view

Function for TNFSF14 Gene

Molecular function for TNFSF14 Gene

GENATLAS Biochemistry: tumor necrosis factor (ligand) superfamily,member 14,highly expressed in splenocytes,activated PBL,CD8+ tumor infiltrating lymphocytes,granulocytes,monocytes,inducing apoptosis
UniProtKB/Swiss-Prot Function: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus
UniProtKB/Swiss-Prot Induction: Up-regulated after T-cell activation

Gene Ontology (GO) - Molecular Function for TNFSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 12393901
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 10318773
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA 12393901
genes like me logo Genes that share ontologies with TNFSF14: view

Phenotypes for TNFSF14 Gene

genes like me logo Genes that share phenotypes with TNFSF14: view

Animal Models for TNFSF14 Gene

MGI Knock Outs for TNFSF14:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TNFSF14 Gene

Localization for TNFSF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF14 Gene

Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein.
Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFSF14 Gene COMPARTMENTS Subcellular localization image for TNFSF14 gene
Compartment Confidence
extracellular 5
plasma membrane 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TNFSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFSF14: view

Pathways for TNFSF14 Gene

genes like me logo Genes that share pathways with TNFSF14: view

Gene Ontology (GO) - Biological Process for TNFSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 10799510
GO:0006955 immune response IEA --
GO:0007165 signal transduction NAS 12393901
GO:0008588 release of cytoplasmic sequestered NF-kappaB IDA 12393901
GO:0010820 positive regulation of T cell chemotaxis IEA --
genes like me logo Genes that share ontologies with TNFSF14: view

Compounds for TNFSF14 Gene

(1) Novoseek inferred chemical compound relationships for TNFSF14 Gene

Compound -log(P) Hits PubMed IDs
vegf 0 1
genes like me logo Genes that share compounds with TNFSF14: view

Transcripts for TNFSF14 Gene

mRNA/cDNA for TNFSF14 Gene

Unigene Clusters for TNFSF14 Gene

Tumor necrosis factor (ligand) superfamily, member 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF14 Gene

No ASD Table

Relevant External Links for TNFSF14 Gene

GeneLoc Exon Structure for
TNFSF14
ECgene alternative splicing isoforms for
TNFSF14

Expression for TNFSF14 Gene

mRNA expression in normal human tissues for TNFSF14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFSF14 Gene

This gene is overexpressed in Liver (19.4) and Whole Blood (11.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNFSF14 Gene

SOURCE GeneReport for Unigene cluster for TNFSF14 Gene Hs.129708

mRNA Expression by UniProt/SwissProt for TNFSF14 Gene

O43557-TNF14_HUMAN
Tissue specificity: Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines
genes like me logo Genes that share expressions with TNFSF14: view

Orthologs for TNFSF14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFSF14 36
  • 98.61 (n)
  • 98.33 (a)
TNFSF14 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNFSF14 36
  • 78.86 (n)
  • 73.15 (a)
TNFSF14 37
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNFSF14 36
  • 82.91 (n)
  • 83.19 (a)
TNFSF14 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnfsf14 36
  • 76.98 (n)
  • 75.85 (a)
Tnfsf14 16
Tnfsf14 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNFSF14 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFSF14 37
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfsf14 36
  • 77.54 (n)
  • 77.12 (a)
lizard
(Anolis carolinensis)
Reptilia TNFSF14 37
  • 42 (a)
OneToOne
Species with no ortholog for TNFSF14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF14 Gene

ENSEMBL:
Gene Tree for TNFSF14 (if available)
TreeFam:
Gene Tree for TNFSF14 (if available)

Paralogs for TNFSF14 Gene

Paralogs for TNFSF14 Gene

genes like me logo Genes that share paralogs with TNFSF14: view

Variants for TNFSF14 Gene

Sequence variations from dbSNP and Humsavar for TNFSF14 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs173171 -- 6,672,583(-) aactt(C/G)tgcct upstream-variant-2KB
rs180763 -- 6,671,881(-) agttc(A/G)agacc upstream-variant-2KB
rs344557 -- 6,671,581(-) caggc(A/G)gatca upstream-variant-2KB
rs344558 -- 6,670,242(-) GCGGG(A/G/T)ACCGG intron-variant, utr-variant-5-prime
rs344559 -- 6,668,526(-) gtttc(A/G)ccatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFSF14 Gene

Variant ID Type Subtype PubMed ID
nsv833728 CNV Loss 17160897

Relevant External Links for TNFSF14 Gene

HapMap Linkage Disequilibrium report
TNFSF14
Human Gene Mutation Database (HGMD)
TNFSF14

Disorders for TNFSF14 Gene

(1) MalaCards Diseases for TNFSF14 Gene

Search for TNFSF14 Gene in MalaCards »

(16) Novoseek inferred disease relationships for TNFSF14 Gene

Disease -log(P) Hits PubMed IDs
herpes 77.5 19
necrosis 60.8 43
herpes simplex 49.2 11
tumors 47.1 63
inflammation 36.6 20

Relevant External Links for TNFSF14

Genetic Association Database (GAD)
TNFSF14
Human Genome Epidemiology (HuGE) Navigator
TNFSF14
genes like me logo Genes that share disorders with TNFSF14: view

No data available for UniProtKB/Swiss-Prot for TNFSF14 Gene

Publications for TNFSF14 Gene

  1. Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis. (PMID: 11673523) Granger S.W. … Ware C.F. (J. Immunol. 2001) 3 4 23
  2. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. (PMID: 9462508) Mauri D.N. … Ware C.F. (Immunity 1998) 2 3 4
  3. Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population. (PMID: 12768436) Lee J.K. … Jo I. (J. Hum. Genet. 2003) 3 49
  4. Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth. (PMID: 9765287) Harrop J.A. … Young P.R. (J. Biol. Chem. 1998) 3 4
  5. Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis. (PMID: 19023130) Sandberg W.J. … Aukrust P. (Circ. Res. 2009) 3 23

Products for TNFSF14 Gene

Sources for TNFSF14 Gene

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