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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFSF14 Gene

protein-coding   GIFtS: 62
GCID: GC19M006663

tumor necrosis factor (ligand) superfamily, member 14
 Explore 42 diseases affiliated with
TNFSF14 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TNFSF14    

Aliases
for TNFSF14 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Necrosis Factor (Ligand) Superfamily, Member 141 2     Delta Transmembrane LIGHT2
LIGHT1 2 3     Herpesvirus Entry Mediator A2
HVEML2 3 5     Herpesvirus Entry Mediator-Ligand2
CD2581 2     Ligand For Herpesvirus Entry Mediator2
LTg1 2     Tumor Necrosis Factor Ligand Superfamily Member 142
HVEM-L1 3     Tumor Necrosis Factor Receptor-Like 22
Herpes Virus Entry Mediator Ligand2 3     Tumor Necrosis Factor Superfamily Member LIGHT2
Herpesvirus Entry Mediator Ligand2 3     CD258 Antigen3
TR22     

External Ids:    HGNC: 119301   Entrez Gene: 87402   Ensembl: ENSG000001257357   OMIM: 6045205   UniProtKB: O435573   

Export aliases for TNFSF14 gene to outside databases

Previous GC identifers: GC19M006759 GC19M006604 GC19M006615 GC19M006425


Summaries
for TNFSF14 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TNFSF14:
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand
for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a
herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid
cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T
cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor
alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct
isoforms have been reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNF14_HUMAN, O43557
Function: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates
NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for
Herpes simplex virus

Gene Wiki entry for TNFSF14


Genomic Views
for TNFSF14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFSF14 gene promoter:
         AP-1   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFSF14 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFSF14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFSF14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TNFSF14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFSF14 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M006663:  view genomic region     (about GC identifiers)

Start:
 6,663,148 bp from pter      End:
 6,670,599 bp from pter
Size:
 7,452 bases      Orientation:
 minus strand

Proteins
for TNFSF14 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TNF14_HUMAN, O43557 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 14  
Size: 240 amino acids; 26350 Da
Subunit: Homotrimer
Subcellular location: Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass
type II membrane protein
Subcellular location: Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted
Subcellular location: Isoform 2: Cytoplasm
1 PDB 3D structure from and Proteopedia for TNFSF14:
4EN0 (3D)    
Secondary accessions: A8K7M2 C9J5H4 O75476 Q6FHA1 Q8WVF8 Q96LD2
Alternative splicing: 2 isoforms:  O43557-1   O43557-2   

Explore the universe of human proteins at neXtProt for TNFSF14: NX_O43557

Post-translational modifications:

  • N-glycosylated1
  • The soluble form of isoform 1 derives from the membrane form by proteolytic processing1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43557

    • TNFSF14 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_003798.2  NP_742011.2  

    ENSEMBL proteins: 
     ENSP00000245912   ENSP00000326940  

    Human Recombinant Protein Products: 
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    Novus Biologicals TNFSF14 Proteins
    Novus Biologicals TNFSF14 Lysate
    Sino Biological Recombinant Protein for TNFSF14
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TNFSF14

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    TNFSF14 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TNFSF14

    Protein Domains /
    Families
    for TNFSF14 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TNFSF14 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006052 TNF
     IPR006053 TNF_a/b/c
     IPR008983 Tumour_necrosis_fac-like_dom

    Graphical View of Domain Structure for InterPro Entry O43557

    ProtoNet protein and cluster: O43557

    2 Blocks protein families:
    IPB006052 Tumor Necrosis Factor
    IPB006053 Tumour necrosis factor family signature


    UniProtKB/Swiss-Prot: TNF14_HUMAN, O43557
    Similarity: Belongs to the tumor necrosis factor family


    Function
    for TNFSF14 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TNF14_HUMAN, O43557
    Function: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates
    NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for
    Herpes simplex virus
    Induction: Up-regulated after T-cell activation

         Genatlas biochemistry entry for TNFSF14:
    tumor necrosis factor (ligand) superfamily,member 14,highly expressed in splenocytes,activated PBL,CD8+ tumor
    infiltrating lymphocytes,granulocytes,monocytes,inducing apoptosis

    miRNA
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    hsa-miR-593 hsa-miR-330-5p hsa-miR-326 hsa-miR-378* hsa-miR-3074-3p hsa-miR-4308 hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmid: TNFSF14 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: TNFSF14
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for TNFSF14

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF14

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI12393901
    GO:0005125cytokine activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding IPI10318773
    GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA12393901


    TNFSF14 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TNFSF14:
     Actin fiber cells 

    Animal Models:
         Mouse knock-outs for TNFSF14: Tnfsf14tm1Kpf Tnfsf14tm1Ddy Tnfsf14tm1Wwh Tnfsf14tm1Lpc
         4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Tnfsf14):
     cellular  hematopoietic system  immune system  renal/urinary system 

    TNFSF14 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TNFSF14 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/9 pathways (see all 9)
    		PEDF Induced Signaling1.00
    		RAR-Gamma-RXR-Alpha Degradation0.54
    		MIF Mediated Glucocorticoid Regulation0.73
    		STAT3 Pathway0.47
    		MIF Regulation of Innate Immune Cells0.71
    		Endothelin-1 Signaling Pathway0.44
    		IL-6 Pathway0.61
    		Cytokine-cytokine receptor interaction0.26
    2Apoptosis and survival_Lymphotoxin-beta receptor signaling
    		Apoptosis and survival Lymphotoxin-beta receptor signaling1.00
    		LT-BetaR Pathway0.46
    		Apoptosis and survival_Lymphotoxin-beta receptor signaling1.00
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    4PAK Pathway
    		PAK Pathway1.00
    		Antioxidant Action of Vitamin-C0.56
    5Akt Signaling
    		Akt Signaling1.00
    		p38 Signaling0.60

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for TNFSF14
        Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Lymphotoxin-beta receptor signaling

    1 R&D Systems Pathway for TNFSF14
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFSF14 (see all 17)
        LT-BetaR Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Rho Family GTPases

    2 GeneGo (Thomson Reuters) Pathways for TNFSF14
        Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Lymphotoxin-beta receptor signaling


    1         Kegg Pathway  (Kegg details for TNFSF14):
        Cytokine-cytokine receptor interaction


    TNFSF14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFSF14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for TNFSF14 (O435571, 3 ENSP000002459124) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF14Q929561, 3, ENSP000003479484EBI-524131,EBI-1056653 I2D: score=4 STRING: ENSP00000347948
    TNFRSF6BO954071, 3, ENSP000003590134EBI-524131,EBI-524171 I2D: score=2 STRING: ENSP00000359013
    LTBQ066433, ENSP000004104814I2D: score=2 STRING: ENSP00000410481
    LTBRP369413, ENSP000002289184I2D: score=3 STRING: ENSP00000228918
    DIABLOQ9NR283, ENSP000002671694I2D: score=2 STRING: ENSP00000267169
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006917induction of apoptosis TAS10799510
    GO:0006955immune response IEA--
    GO:0007165signal transduction NAS12393901
    GO:0008588release of cytoplasmic sequestered NF-kappaB IDA12393901
    GO:0031295T cell costimulation ----


    TNFSF14 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TNFSF14 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNFSF14 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFSF14
    1 Novoseek chemical compound relationship for TNFSF14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 0 1 19128255 (1)

    Search CenterWatch for drugs/clinical trials and news about TNFSF14 / TNF14 

    Transcripts
    for TNFSF14 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TNFSF14 gene (2 alternative transcripts): 
    NM_003807.3  NM_172014.2  

    Unigene Cluster for TNFSF14:

    Tumor necrosis factor (ligand) superfamily, member 14
    Hs.129708  [show with all ESTs]
    Unigene Representative Sequence: NM_003807
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000245912(uc002mfk.2) ENST00000326176(uc002mfj.2)

    miRNA
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    hsa-miR-593 hsa-miR-330-5p hsa-miR-326 hsa-miR-378* hsa-miR-3074-3p hsa-miR-4308 hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmid: TNFSF14 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF036581.1 AF064090.1 AK026704.1 AK292037.1 AY028261.1 AY358812.1 BC018058.1 CR541854.1 
    CR541871.1 

    3 DOTS entries:

    DT.40127949  DT.75107589  DT.95261466 

    24/731 AceView cDNA sequences (see all 731):

    BG618714 AA344318 BQ723278 BQ881908 CA393142 AI133649 NM_003807 BI823457 
    BQ641572 AI133462 BF379269 BG542872 BQ694606 AA166723 AA343382 K02765 
    T61804 BP360492 T53801 AF064090 NM_000064 BU839610 AL531738 AI207565 

    GeneLoc Exon Structure


    Expression
    for TNFSF14 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFSF14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TNFSF14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFSF14

    SOURCE GeneReport for Unigene cluster: Hs.129708

    UniProtKB/Swiss-Prot: TNF14_HUMAN, O43557
    Tissue specificity: Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral
    lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues,
    endocrine glands, or nonhematopoietic tumor lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFSF14 (see all 10): 
              Inflammasomes in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFSF14
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF14

    Orthologs
    for TNFSF14 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TNFSF14 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tnfsf141 , 5 tumor necrosis factor (ligand) superfamily, member more1, 5 78.39(n)1
    77.97(a)1    		   17 (29.71 cM)5
    509301  NM_019418.21  NP_062291.11 
     571894925 
    lizard
    (Anolis carolinensis)    		 Reptilia TNFSF146
    		 --
    		 44(a)
    		 1 ↔ 1
    		 2(75906218-75908936)
    zebrafish
    (Danio rerio)    		 Actinopterygii BX088529.16
    		 --
    		 26(a)
    		 1 ↔ 1
    		 3(48434311-48444162)


    ENSEMBL Gene Tree for TNFSF14 (if available)
    TreeFam Gene Tree for TNFSF14 (if available) 

    Paralogs
    for TNFSF14 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFSF14 gene
    FASLG2  TNFSF152  LTA2  TNF2  

    TNFSF14 for paralogs           About GeneDecksing



    Genomic Variants
    for TNFSF14 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/224 NCBI SNPs in TNFSF14 are shown (see all 224)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1421393901,2
    		--6662742(+) TTGTAC/TGCATA 2 -- ds50010--------
    rs104103891,2
    		H--6662762(+) GCCCCC/TACCCA 2 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs1459865801,2
    		--6662764(+) CCCCAC/TCCAAC 2 -- ds50010--------
    rs1388612391,2
    		--6662847(+) AGGGCA/GTCTTG 2 -- ds50010--------
    rs1493175401,2
    		--6662854(+) CTTGCA/GGGATG 2 -- ds50010--------
    rs1840196771,2
    		--6662911(+) CCAGAC/TGTGAG 2 -- ds50010--------
    rs1446487541,2
    		--6663009(+) ACCTCC/TATCCC 2 -- ds50010--------
    rs1480852231,2
    		--6663092(+) CTTTAA/GGCCTG 2 -- ds50010--------
    rs1884406731,2
    		--6663126(+) AGTTTG/TTTCCC 2 -- ds50010--------
    rs1418464321,2
    		--6663156(+) AGGTAC/GAACTA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for TNFSF14 (6663148 - 6670599 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TNFSF14
         1 CNV: 5076
    Human Gene Mutation Database (HGMD): TNFSF14

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    Disorders / Diseases
    for TNFSF14 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TNFSF14 for disorders           About GeneDecksing

    OMIM gene information: 604520    OMIM disorders: --

    20/42 diseases for TNFSF14 (see all 42):    About MalaCards
    diffuse large b-cell lymphoma    graft versus host disease    testicular leydig cell tumor    b-cell lymphomas
    herpes simplex    leydig cell tumor    asthenopia    rheumatoid arthritis
    chronic lymphocytic leukemia    vascular dementia    lymphocytic leukemia    viral hepatitis
    kaposi's sarcoma    cystitis    multiple myeloma    hypertriglyceridemia
    osteoarthritis    dementia    crohn's disease    hepatitis b

    2 diseases from the University of Copenhagen DISEASES database for TNFSF14:
    Testicular Leydig cell tumor     Asthenopia

    10/16 Novoseek disease relationships for TNFSF14 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes 77.5 23 12566458 (2), 18412315 (2), 11035077 (2), 14704792 (1) (see all 16)
    necrosis 60.8 53 9739048 (2), 12393901 (2), 19426225 (2), 19128255 (2) (see all 39)
    herpes simplex 49.2 12 12466117 (1), 12566458 (1), 15814693 (1), 16131544 (1) (see all 11)
    tumors 47.1 78 9739048 (7), 20460520 (5), 12393901 (2), 10894944 (2) (see all 47)
    inflammation 36.6 25 15067315 (4), 17015945 (2), 15634882 (2), 15925518 (2) (see all 13)
    rheumatoid arthritis 32.1 15 17393389 (2), 17426140 (2), 16649193 (2), 18412315 (2) (see all 6)
    osteoarthritis 23.8 5 15667572 (1), 17426140 (1), 18412315 (1)
    inflammatory bowel diseases 21.9 6 17570213 (3), 15634882 (1), 15925518 (1)
    atherosclerotic plaque 21.3 5 15667572 (1), 19023130 (1), 16972254 (1)
    colitis 8.51 2 15925518 (2)

    Human Genome Epidemiology (HuGE) Navigator: TNFSF14 (10 documents)

    Export disorders for TNFSF14 gene to outside databases

    Publications
    for TNFSF14 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFSF14 gene, integrated from 9 sources (see all 142):
    (articles sorted by number of sources associating them with TNFSF14)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. (PubMed id 9462508)1, 2, 3 Mauri D.N....Ware C.F. (1998)
    2. Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis. (PubMed id 11673523)1, 2, 9 Granger S.W.... Ware C.F. (2001)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth. (PubMed id 9765287)1, 2 Harrop J.A.... Young P.R. (1998)
    5. Proinflammatory and prothrombotic effects on human vascular endothelial cells of immune-cell-derived LIGHT. (PubMed id 19380287)1, 9 Celik S....Dengler T.J. (2009)
    6. Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor. (PubMed id 11035077)1, 9 Morel Y....Costello R.T. (2000)
    7. LIGHT induces cell proliferation and inflammatory responses of rheumatoid arthritis synovial fibroblasts via lymphotoxin beta receptor. (PubMed id 18412315)1, 9 Ishida S....Suzuki R. (2008)
    8. LIGHT, a member of the tumor necrosis factor ligand superfamily, prevents tumor necrosis factor-alpha-mediated human primary hepatocyte apoptosis, but not Fas-mediated apoptosis. (PubMed id 12393901)1, 9 Matsui H....Shintani Y. (2002)
    9. LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling. (PubMed id 15634882)1, 9 Cohavy O....Targan S.R. (2005)
    10. LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer. (PubMed id 9739048)1, 9 Zhai Y....Yang D. (1998)

    External Searches for TNFSF14 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing TNFSF14 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8740 HGNC: 11930 AceView: C3andTNFSF14 Ensembl:ENSG00000125735 euGenes: HUgn8740
    ECgene: TNFSF14 Kegg: 8740 H-InvDB: TNFSF14

    Other Databases showing TNFSF14 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TNFSF14 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFSF14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFSF14 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TNFSF14 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TNFSF14 gene:
    Search GeneIP for patents involving TNFSF14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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