TNFSF13B Gene
protein-coding GIFtS: 67
GCID: GC13P108903
|
|
tumor necrosis factor (ligand) superfamily, member 13b
(Previous symbol: TNFSF20)
| |
Aliases
for TNFSF13B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tumor Necrosis Factor (Ligand) Superfamily, Member 13b1 2 | | B-Lymphocyte Stimulator2 | | BAFF1 2 3 5 | | Delta BAFF2 | | BLYS1 2 3 5 | | Delta4 BAFF2 | | TALL-11 2 3 | | TNF And ApoL-Related Leukocyte Expressed Ligand 12 | | TALL11 2 3 | | TNF Homolog That Activates Apoptosis2 | | TNFSF201 2 3 | | Tumor Necrosis Factor (Ligand) Superfamily, Member 202 | | CD2571 2 | | Tumor Necrosis Factor Ligand Superfamily Member 13B2 | | THANK1 2 | | Tumor Necrosis Factor-Like Protein ZTNF42 | | Dendritic Cell-Derived TNF-Like Molecule2 3 | | BLyS3 | | ZTNF42 3 | | B Lymphocyte Stimulator3 | | B-Cell-Activating Factor2 3 | | CD257 Antigen3 | | DTL2 | | TNF- And APOL-Related Leukocyte Expressed Ligand 13 | | ApoL Related Ligand TALL-12 | | |
Export aliases for TNFSF13B gene to outside databasesPrevious GC identifers: GC13P107281 GC13P103309 GC13P107758 GC13P106619 GC13P107719 GC13P089512 |
Summaries
for TNFSF13B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TNFSF13B:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. Thiscytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in Bcell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in theproliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoformshave been identified. (provided by RefSeq, Mar 2011)
UniProtKB/Swiss-Prot: TN13B_HUMAN, Q9Y275Function: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors.Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and theregulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of matureB-cells and the B-cell responseFunction: Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity)
Gene Wiki entry for TNFSF13B (B-cell activating factor)
|
Genomic Views
for TNFSF13B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_009952.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TNFSF13B gene promoter:
AP-1 ATF-2 Evi-1 C/EBPalpha PPAR-gamma1 c-Jun PPAR-gamma2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for TNFSF13B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFSF13B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q32-q34 Ensembl cytogenetic band: 13q33.3 HGNC cytogenetic band: 13q32-q34TNFSF13B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P108903: view genomic region
(about GC identifiers)
Start:
|
108,903,588 bp from pter |
End:
|
108,959,385 bp from pter |
Size:
|
55,798 bases |
Orientation:
|
plus strand |
|
Proteins
for TNFSF13B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TN13B_HUMAN, Q9Y275 (See
protein sequence)Recommended Name: Tumor necrosis factor ligand superfamily member 13B Size: 285 amino acids; 31223 Da
Subunit: Homotrimer. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1on the cell surface
Subcellular location: Cell membrane; Single-pass type II membrane protein
Subcellular location: Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted
6/8 PDB 3D structures from  and Proteopedia  for TNFSF13B (see all 8):1JH5 (3D)
1KD7 (3D)
1KXG (3D)
1OQD (3D)
1OQE (3D)
1OSG (3D)
Secondary accessions: Q6FHD6 Q7Z5J2Alternative splicing: 2 isoforms: Q9Y275-1 Q9Y275-2 Explore the universe of human proteins at neXtProt for TNFSF13B: NX_Q9Y275
Post-translational modifications:
The soluble form derives from the membrane form by proteolytic processing1
Isoform 2 is not efficiently shed from the membrane unlike isoform 1 (By similarity)1
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y275
TNFSF13B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001139117.1 NP_006564.1
ENSEMBL proteins: ENSP00000365048 ENSP00000389540 ENSP00000445334
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TNFSF13B for ontologies About GeneDecksing
TNFSF13B Antibody Products:
Assay Products for TNFSF13B: |
Protein
Domains /
Families
for TNFSF13B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TNFSF13B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y275ProtoNet protein and cluster: Q9Y275 1 Blocks protein family: IPB006052 Tumor Necrosis Factor
UniProtKB/Swiss-Prot: TN13B_HUMAN, Q9Y275Similarity: Belongs to the tumor necrosis factor family |
Function
for TNFSF13B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TN13B_HUMAN, Q9Y275Function: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors.Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and theregulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of matureB-cells and the B-cell responseFunction: Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity)Induction: Up-regulated by exposure to IFNG/IFN-gamma. Down-regulated by phorbol myristate acetate/ionomycin treatment Genatlas biochemistry entry for TNFSF13B:tumor necrosis factor (ligand) superfamily,member 13B,expressed abundantly in peripheral blood leukocytes T cell anddendritic cells and weakly in spleen,inducing the proliferation of anti IgM stimulated peripheral blood B lymphocyte
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF13B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF13B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TNFSF13B (NM_006573) | |  | Sino Biological Human cDNA Clone for TNFSF13B | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNFSF13B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF13B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF13B |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TNFSF13B for ontologies About GeneDecksing
Animal Models:
3 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Tnfsf13b):
TNFSF13B for phenotypes About GeneDecksing
|
Pathways & Interactions
for TNFSF13B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | PEDF Induced Signaling | | | 2 | TGF-Beta Pathway | | | 3 | Akt Signaling | | | 4 | Rho Family GTPases | | | 5 | TRAF Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for TNFSF13B
1  R&D Systems Pathway for TNFSF13B
5/29 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFSF13B (see all 29)
1 
Cell Signaling Technology (CST) Pathway for TNFSF13B
2  GeneGo (Thomson Reuters) Pathways for TNFSF13B
3 
Kegg Pathways (Kegg details for TNFSF13B):
TNFSF13B for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFSF13B
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for TNFSF13B (Q9Y2751, 3 ENSP000003650484) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
TNFSF13B for ontologies About GeneDecksing
|
Drugs & Compounds
for TNFSF13B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TNFSF13B for compounds About GeneDecksing
 Browse Tocris compounds for TNFSF13B
2 DrugBank Compounds for TNFSF13B About this table
7 Novoseek chemical compound relationships for TNFSF13B gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| bcma |
97.2 |
84 |
15697217 (6), 10908663 (5), 14764606 (5), 16960154 (4) (see all 46) |
| blys |
96.4 |
208 |
11133761 (10), 12621010 (9), 19731825 (7), 10398604 (7) (see all 59) |
| rituximab |
66.3 |
22 |
19088870 (3), 17092341 (3), 18510703 (3), 19282839 (2) (see all 10) |
| thymidine |
0 |
1 |
11714784 (1) |
| calcium |
0 |
10 |
19737141 (1), 16818641 (1), 15070697 (1), 15908449 (1) (see all 9) |
| alanine |
0 |
2 |
17584580 (1), 14764606 (1) |
| creatinine |
0 |
1 |
18628284 (1) |
Search CenterWatch for drugs/clinical trials and news about TNFSF13B / TN13B
|
Transcripts
for TNFSF13B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TNFSF13B gene (2 alternative transcripts): NM_001145645.2 NM_006573.4 Unigene Cluster for TNFSF13B: Tumor necrosis factor (ligand) superfamily, member 13b Hs.525157 [show with all ESTs]Unigene Representative Sequence: NM_0065736 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000486502 ENST00000375887 ENST00000479435(uc001vqs.1) ENST00000493765
ENST00000430559(uc001vqr.3 uc010agj.3) ENST00000542136
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF13B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF13B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TNFSF13B (NM_006573) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNFSF13B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF13B |
Additional cDNA sequence: AF116456.1 AF132600.1 AF134715.1 AF136293.1 AF186114.1 AK309629.1 AY129225.1 AY129226.1 AY129227.1 AY129228.1 AY302751.1 AY358881.1 BC020674.1 CR541818.1 DQ857727.1 DQ857728.1 HM636064.1 6 DOTS entries: DT.207328 DT.99956687 DT.101982692 DT.100023471 DT.92424206 DT.92424207 24/49 AceView cDNA sequences (see all 49): BM931041 AF132600 BX646857 CR541818 AA906714 AY129225 AF150302 BI832664 NM_006573 AF134715 AF116456 AY358881 AF186114 AY302751 BC020674 BI818459 CD370869 BU929202 AV710643 BI908928 AV712599 AY129227 BX110396 BU929119
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF13B About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for TNFSF13B
|
Expression
for TNFSF13B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TNFSF13B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGTAGCTA
About this image
See TNFSF13B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFSF13B
SOURCE GeneReport for Unigene cluster: Hs.525157
UniProtKB/Swiss-Prot: TN13B_HUMAN, Q9Y275Tissue specificity: Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes andmacrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seenin placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines
SABiosciences Expression via Pathway-Focused PCR Arrays including TNFSF13B (see all 7):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFSF13B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNFSF13B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFSF13B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFSF13B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF13B |
Orthologs
for TNFSF13B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TNFSF13B gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for TNFSF13B (if available)
TreeFam Gene Tree for TNFSF13B (if available) |
Paralogs
for TNFSF13B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TNFSF13B gene
- TNFSF12-TNFSF132 TNFSF122 TNFSF132
1 SIMAP similar gene for TNFSF13B using alignment to 5 protein entries: TN13B_HUMAN (see all proteins):TNFSF13
TNFSF13B for paralogs About GeneDecksing
|
Genomic Variants
for TNFSF13B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TNFSF13B (108903588 - 108959385 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TNFSF13B
3 CNVs: 66545 87021 87022
1 Indel: 101852
Human Gene Mutation Database (HGMD): TNFSF13B
| SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing TNFSF13B: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFSF13B |
|
Disorders
/ Diseases
for TNFSF13B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TNFSF13B for disorders About GeneDecksing
OMIM gene information: 603969
OMIM disorders: --
20/83  diseases for TNFSF13B (see all 83): About MalaCardsb-cell non-hodgkin lymphoma common variable immunodeficiency diffuse large b-cell lymphoma non-hodgkin lymphoma
pemphigus vulgaris neuromyelitis optica central nervous system lymphoma graft versus host disease
myasthenia gravis b-cell lymphomas pemphigus foliaceus waldenstrom macroglobulinemia
localized scleroderma severe combined immunodeficiency pemphigus alopecia areata
wegener's granulomatosis familial chronic lymphocytic leukemia bullous pemphigoid chronic lymphocytic leukemia
4 diseases from the University of Copenhagen DISEASES database for TNFSF13B:Systemic lupus erythematosus Rheumatoid arthritis Lymphoma Sjogren's syndrome 10/35 Novoseek disease relationships for TNFSF13B gene (see all 35) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| autoimmune diseases |
79.6 |
117 |
18395853 (3), 19737141 (3), 19507632 (3), 16863659 (3) (see all 63) |
| autoimmunity |
74.2 |
55 |
17029886 (3), 17171221 (3), 15790349 (3), 18395853 (2) (see all 33) |
| lupus erythematosus systemic |
73.5 |
61 |
17506477 (2), 18718031 (2), 17500077 (2), 19565488 (2) (see all 33) |
| necrosis |
70.7 |
222 |
10880535 (2), 18243342 (2), 17500077 (2), 17220480 (2) (see all 99) |
| common variable immunodeficiency |
63.1 |
4 |
14597212 (1), 17689597 (1), 18051214 (1), 17556024 (1) |
| sjogrens syndrome primary |
61.1 |
4 |
16093833 (1), 16014518 (1), 18617551 (1), 15981083 (1) |
| rheumatoid arthritis |
55.1 |
43 |
19291304 (3), 17963166 (2), 18528969 (2), 17092341 (2) (see all 19) |
| lymphoma b-cell |
53 |
3 |
18510703 (2), 18628489 (1) |
| tumors |
49.9 |
183 |
12621010 (4), 10880535 (2), 18243342 (2), 16818641 (2) (see all 99) |
| leukemia lymphocytic chronic |
48.1 |
18 |
17768131 (2), 18556064 (2), 19291294 (1), 15860672 (1) (see all 7) |
Genetic Association Database (GAD): TNFSF13B
Human Genome Epidemiology (HuGE) Navigator: TNFSF13B (15 documents)
Export disorders for TNFSF13B gene to outside databases
|
Publications
for TNFSF13B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TNFSF13B gene, integrated from 9 sources (see all 472):
(articles sorted by number of sources associating them with TNFSF13B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. (PubMed id 10359578)1, 2, 3, 9 Schneider P....Tschopp J. (1999)
- TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. (PubMed id 10331498)1, 2, 3 Shu H.-B.... Johnson H. (1999)
- BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. (PubMed id 10398604)1, 2, 9 Moore P.A.... Hilbert D.M. (1999)
- Analysis on the association of human BLYS (BAFF, TNFSF13B) polymorphisms with systemic lupus erythematosus and rheumatoid arthritis. (PubMed id 12424625)1, 4, 9 Kawasaki A....Tokunaga K. (2002)
- DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF. (PubMed id 12867412)1, 2, 9 Gavin A.L.... Nemazee D. (2003)
- Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes. (PubMed id 11827482)1, 2, 9 Karpusas M.... Kalled S.L. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Structural basis of BLyS receptor recognition. (PubMed id 11862220)1, 2 Oren D.A.... Arnold E. (2002)
- Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands. (PubMed id 11853672)1, 2 Liu Y.... Zhang G. (2002)
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External Searches for TNFSF13B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TNFSF13B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TNFSF13B gene
(According to HUGE)
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Specialized Databases showing TNFSF13B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for TNFSF13B gene:
Search GeneIP for patents involving TNFSF13B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TNFSF13B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for TNFSF13B | | OriGene shRNA RFP for TNFSF13B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFSF13B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFSF13B | | | OriGene Protein Over-expression Lysate for TNFSF13B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TNFSF13B | | OriGene 3'-UTR Clone for TNFSF13B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF13B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF13B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TNFSF13B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TNFSF13B | | OriGene Custom Protein Services for TNFSF13B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TNFSF13B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFSF13B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFSF13B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFSF13B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFSF13B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFSF13B |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF13B |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF13B |
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