Aliases for TNFSF13B Gene
- Tumor Necrosis Factor (Ligand) Superfamily, Member 13b 2 3
- Dendritic Cell-Derived TNF-Like Molecule 3 4
- B-Cell-Activating Factor 3 4
- TNFSF20 3 4
- TALL-1 3 4
- TALL1 3 4
- ZTNF4 3 4
- BAFF 3 4
- BLYS 3 4
- Tumor Necrosis Factor (Ligand) Superfamily, Member 20 3
- TNF- And APOL-Related Leukocyte Expressed Ligand 1 4
- TNF And ApoL-Related Leukocyte Expressed Ligand 1 3
External Ids for TNFSF13B Gene
Previous HGNC Symbols for TNFSF13B Gene
Previous GeneCards Identifiers for TNFSF13B Gene
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
GeneCards Summary for TNFSF13B Gene
TNFSF13B (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b) is a Protein Coding gene. Diseases associated with TNFSF13B include sialadenitis and igg4-related disease. Among its related pathways are Immune System and TGF-Beta Pathway. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF13.
UniProtKB/Swiss-Prot for TNFSF13B Gene
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.
Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.