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Aliases for TNFSF13B Gene

Aliases for TNFSF13B Gene

  • Tumor Necrosis Factor (Ligand) Superfamily, Member 13b 2 3
  • Dendritic Cell-Derived TNF-Like Molecule 3 4
  • B-Cell-Activating Factor 3 4
  • TNFSF20 3 4
  • TALL-1 3 4
  • TALL1 3 4
  • ZTNF4 3 4
  • BAFF 3 4
  • BLYS 3 4
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 20 3
  • TNF- And APOL-Related Leukocyte Expressed Ligand 1 4
  • TNF And ApoL-Related Leukocyte Expressed Ligand 1 3
  • Tumor Necrosis Factor-Like Protein ZTNF4 3
  • TNF Homolog That Activates Apoptosis 3
  • ApoL Related Ligand TALL-1 3
  • B-Lymphocyte Stimulator 3
  • B Lymphocyte Stimulator 4
  • CD257 Antigen 4
  • Delta4 BAFF 3
  • Delta BAFF 3
  • CD257 3
  • THANK 3
  • DTL 3

External Ids for TNFSF13B Gene

Previous HGNC Symbols for TNFSF13B Gene

  • TNFSF20

Previous GeneCards Identifiers for TNFSF13B Gene

  • GC13P107281
  • GC13P103309
  • GC13P107758
  • GC13P106619
  • GC13P107719
  • GC13P108903
  • GC13P089512

Summaries for TNFSF13B Gene

Entrez Gene Summary for TNFSF13B Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

GeneCards Summary for TNFSF13B Gene

TNFSF13B (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b) is a Protein Coding gene. Diseases associated with TNFSF13B include sialadenitis and igg4-related disease. Among its related pathways are Immune System and TGF-Beta Pathway. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF13.

UniProtKB/Swiss-Prot for TNFSF13B Gene

  • Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.

  • Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.

  • Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.

Gene Wiki entry for TNFSF13B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF13B Gene

Genomics for TNFSF13B Gene

Regulatory Elements for TNFSF13B Gene

Genomic Location for TNFSF13B Gene

Chromosome:
13
Start:
108,251,240 bp from pter
End:
108,308,484 bp from pter
Size:
57,245 bases
Orientation:
Plus strand

Genomic View for TNFSF13B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFSF13B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF13B Gene

Proteins for TNFSF13B Gene

  • Protein details for TNFSF13B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y275-TN13B_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 13B
    Protein Accession:
    Q9Y275
    Secondary Accessions:
    • E0ADT7
    • Q6FHD6
    • Q7Z5J2

    Protein attributes for TNFSF13B Gene

    Size:
    285 amino acids
    Molecular mass:
    31223 Da
    Quaternary structure:
    • Homotrimer. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1 on the cell surface. Isoform 3 is unlikely form trimers or bind to BAFF receptors.

    Three dimensional structures from OCA and Proteopedia for TNFSF13B Gene

    Alternative splice isoforms for TNFSF13B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFSF13B Gene

Proteomics data for TNFSF13B Gene at MOPED

Post-translational modifications for TNFSF13B Gene

Other Protein References for TNFSF13B Gene

Antibody Products

  • R&D Systems Antibodies for TNFSF13B (BAFF/BLyS/TNFSF13B)
  • Cell Signaling Technology (CST) Antibodies for TNFSF13B (BAFF)

Protein Products

  • Enzo Life Sciences proteins for TNFSF13B

No data available for DME Specific Peptides for TNFSF13B Gene

Domains & Families for TNFSF13B Gene

Gene Families for TNFSF13B Gene

Protein Domains for TNFSF13B Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y275

UniProtKB/Swiss-Prot:

TN13B_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF13B: view

Function for TNFSF13B Gene

Molecular function for TNFSF13B Gene

GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 13B,expressed abundantly in peripheral blood leukocytes T cell and dendritic cells and weakly in spleen,inducing the proliferation of anti IgM stimulated peripheral blood B lymphocyte
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
UniProtKB/Swiss-Prot Function:
Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.
UniProtKB/Swiss-Prot Function:
Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.
UniProtKB/Swiss-Prot Induction:
Up-regulated by exposure to IFNG/IFN-gamma. Down-regulated by phorbol myristate acetate/ionomycin treatment

Gene Ontology (GO) - Molecular Function for TNFSF13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10908663
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 10801128
genes like me logo Genes that share ontologies with TNFSF13B: view

Phenotypes for TNFSF13B Gene

MGI mutant phenotypes for TNFSF13B:
inferred from 3 alleles
GenomeRNAi human phenotypes for TNFSF13B:
genes like me logo Genes that share phenotypes with TNFSF13B: view

Animal Model Products

CRISPR Products

miRNA for TNFSF13B Gene

miRTarBase miRNAs that target TNFSF13B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFSF13B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFSF13B Gene

Localization for TNFSF13B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF13B Gene

Cell membrane; Single-pass type II membrane protein.
Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFSF13B Gene COMPARTMENTS Subcellular localization image for TNFSF13B gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TNFSF13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IDA 19828625
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with TNFSF13B: view

Pathways & Interactions for TNFSF13B Gene

genes like me logo Genes that share pathways with TNFSF13B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for TNFSF13B Gene

Activates:

Gene Ontology (GO) - Biological Process for TNFSF13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001782 B cell homeostasis IEA --
GO:0002636 positive regulation of germinal center formation IEA --
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 10908663
GO:0008283 cell proliferation TAS 10908663
genes like me logo Genes that share ontologies with TNFSF13B: view

Drugs & Compounds for TNFSF13B Gene

(10) Drugs for TNFSF13B Gene - From: NovoSeek, DGIdb, DrugBank, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
belimumab Approved Pharma antibody, Target, neutralizer Therapeutic Antibodies 44
rituximab Approved Pharma Therapeutic Antibodies 1514
1,4-Diethylene Dioxide Experimental Pharma Target 0
thymidine Experimental Pharma 0
Citric Acid Nutra Agonist, Activator, Target 784

(3) Additional Compounds for TNFSF13B Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BCMA
BLyS
Creatinine
  • 1-Methylglycocyamidine
  • 1-Methylhydantoin-2-imide
  • 2-Amino-1-methyl-1,5-dihydroimidazol-4-one
  • 2-Amino-1-methylimidazolin-4-one
  • Creatine anhydride
60-27-5
genes like me logo Genes that share compounds with TNFSF13B: view

Transcripts for TNFSF13B Gene

Unigene Clusters for TNFSF13B Gene

Tumor necrosis factor (ligand) superfamily, member 13b:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFSF13B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF13B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3:
SP4: -

Relevant External Links for TNFSF13B Gene

GeneLoc Exon Structure for
TNFSF13B
ECgene alternative splicing isoforms for
TNFSF13B

Expression for TNFSF13B Gene

mRNA expression in normal human tissues for TNFSF13B Gene

mRNA differential expression in normal tissues according to GTEx for TNFSF13B Gene

This gene is overexpressed in Whole Blood (x24.7).

Protein differential expression in normal tissues from HIPED for TNFSF13B Gene

This gene is overexpressed in Ovary (26.1), Esophagus (21.2), Peripheral blood mononuclear cells (14.2), and Blymphocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFSF13B Gene



SOURCE GeneReport for Unigene cluster for TNFSF13B Gene Hs.525157

mRNA Expression by UniProt/SwissProt for TNFSF13B Gene

Q9Y275-TN13B_HUMAN
Tissue specificity: Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines.
genes like me logo Genes that share expression patterns with TNFSF13B: view

Protein tissue co-expression partners for TNFSF13B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TNFSF13B Gene

Orthologs for TNFSF13B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF13B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TNFSF13B 35
  • 82.01 (n)
  • 79.5 (a)
TNFSF13B 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNFSF13B 35
  • 83.16 (n)
  • 79.3 (a)
TNFSF13B 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnfsf13b 35
  • 71.82 (n)
  • 71.32 (a)
Tnfsf13b 16
Tnfsf13b 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNFSF13B 35
  • 99.88 (n)
  • 99.65 (a)
TNFSF13B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfsf13b 35
  • 66.01 (n)
  • 55.56 (a)
oppossum
(Monodelphis domestica)
Mammalia TNFSF13B 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFSF13B 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNFSF13B 35
  • 62.63 (n)
  • 56.06 (a)
-- 36
  • 67 (a)
OneToMany
BAFF 36
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TNFSF13B 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfsf13b 35
  • 58.41 (n)
  • 50.46 (a)
zebrafish
(Danio rerio)
Actinopterygii tnfsf13b 35
  • 54.13 (n)
  • 46.33 (a)
tnfsf13b 36
  • 38 (a)
OneToOne
Species with no ortholog for TNFSF13B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFSF13B Gene

ENSEMBL:
Gene Tree for TNFSF13B (if available)
TreeFam:
Gene Tree for TNFSF13B (if available)

Paralogs for TNFSF13B Gene

Paralogs for TNFSF13B Gene

(1) SIMAP similar genes for TNFSF13B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TNFSF13B: view

Variants for TNFSF13B Gene

Sequence variations from dbSNP and Humsavar for TNFSF13B Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_013483 -

Structural Variations from Database of Genomic Variants (DGV) for TNFSF13B Gene

Variant ID Type Subtype PubMed ID
esv2747975 CNV Deletion 23290073
esv2563318 CNV Insertion 19546169
nsv510624 CNV Loss 20534489
nsv526850 CNV Gain 19592680
dgv379e199 CNV Deletion 23128226
esv2747976 CNV Deletion 23290073
esv27365 CNV Loss 19812545

Variation tolerance for TNFSF13B Gene

Residual Variation Intolerance Score: 33.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFSF13B Gene

HapMap Linkage Disequilibrium report
TNFSF13B
Human Gene Mutation Database (HGMD)
TNFSF13B

PCR Panel Products

  • Copy Number PCR Panels: for TNFSF13B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF13B Gene

Disorders for TNFSF13B Gene

MalaCards: The human disease database

(26) MalaCards diseases for TNFSF13B Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
sialadenitis
  • sialoadenitis
igg4-related disease
  • hyper-igg4 disease
chronic graft versus host disease
  • chronic gvhd
macroglobulinemia
  • waldenstrom macroglobulinemia
neuromyelitis optica
  • devic's syndrome
- elite association

Relevant External Links for TNFSF13B

Genetic Association Database (GAD)
TNFSF13B
Human Genome Epidemiology (HuGE) Navigator
TNFSF13B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFSF13B
genes like me logo Genes that share disorders with TNFSF13B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF13B Gene

Publications for TNFSF13B Gene

  1. Baseline autoantibody profiles predict normalization of complement and anti-dsDNA autoantibody levels following rituximab treatment in systemic lupus erythematosus. (PMID: 19946034) Tew G.W. … Keir M.E. (Lupus 2010) 23 67
  2. B cells as therapeutic targets in SLE. (PMID: 20520647) Sanz I. … Lee F.E. (Nat Rev Rheumatol 2010) 23 67
  3. New targets of PS-341: BAFF and APRIL. (PMID: 19452288) Li W. … Luo S. (Med. Oncol. 2010) 23 67
  4. BLyS and APRIL expression in peripheral blood mononuclear cells of cryptococcal meningitis patients and their clinical significance. (PMID: 19909733) Xia R. … Wen H. (Clin. Biochem. 2010) 23 67
  5. Multiple novel classes of APRIL-specific receptor-blocking peptides isolated by phage display. (PMID: 19945466) Gordon N.C. … Kelley R.F. (J. Mol. Biol. 2010) 23 67

Products for TNFSF13B Gene

Sources for TNFSF13B Gene

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