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TNFSF13B Gene

protein-coding   GIFtS: 68
GCID: GC13P108903

Tumor Necrosis Factor (Ligand) Superfamily, Member 13b


(Previous symbol: TNFSF20)
  See TNFSF13B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tumor Necrosis Factor (Ligand) Superfamily, Member 13b1 2     B-Lymphocyte Stimulator2
TNFSF201 2 3     Delta BAFF2
BAFF2 3 5     Delta4 BAFF2
BLYS2 3 5     TNF And ApoL-Related Leukocyte Expressed Ligand 12
Dendritic Cell-Derived TNF-Like Molecule2 3     TNF Homolog That Activates Apoptosis2
TALL-12 3     Tumor Necrosis Factor (Ligand) Superfamily, Member 202
TALL12 3     Tumor Necrosis Factor Ligand Superfamily Member 13B2
ZTNF42 3     Tumor Necrosis Factor-Like Protein ZTNF42
B-Cell-Activating Factor2 3     BLyS3
CD2572     B Lymphocyte Stimulator3
DTL2     CD257 Antigen3
THANK2     TNF- And APOL-Related Leukocyte Expressed Ligand 13
ApoL Related Ligand TALL-12     

External Ids:    HGNC: 119291   Entrez Gene: 106732   Ensembl: ENSG000001025247   OMIM: 6039695   UniProtKB: Q9Y2753   
ORGUL members:         

Export aliases for TNFSF13B gene to outside databases

Previous GC identifers: GC13P107281 GC13P103309 GC13P107758 GC13P106619 GC13P107719 GC13P089512


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFSF13B Gene:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This
cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed
in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role
in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct
isoforms have been identified. (provided by RefSeq, Mar 2011)

GeneCards Summary for TNFSF13B Gene:
TNFSF13B (tumor necrosis factor (ligand) superfamily, member 13b) is a protein-coding gene. Diseases associated with TNFSF13B include sialadenitis, and chronic lymphocytic leukemia. GO annotations related to this gene include tumor necrosis factor receptor binding and receptor binding. An important paralog of this gene is TNFSF12-TNFSF13.

UniProtKB/Swiss-Prot: TN13B_HUMAN, Q9Y275
Function: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors.
Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and
the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of
mature B-cells and the B-cell response
Function: Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity)
Function: Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50
subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for
soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or
indirectly regulate the differential expression of a large number of genes involved in the innate immune response
and the regulation of apoptosis

Gene Wiki entry for TNFSF13B (B-cell activating factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_009952.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFSF13B gene promoter:
         AP-1   ATF-2   Evi-1   C/EBPalpha   PPAR-gamma1   c-Jun   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFSF13B promoter sequence
   Search Chromatin IP Primers for TNFSF13B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFSF13B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32-q34   Ensembl cytogenetic band:  13q33.3   HGNC cytogenetic band: 13q32-q34

TNFSF13B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFSF13B gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P108903:  view genomic region     (about GC identifiers)

Start:
108,903,588 bp from pter      End:
108,960,832 bp from pter
Size:
57,245 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TN13B_HUMAN, Q9Y275 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 13B  
Size: 285 amino acids; 31223 Da
Subunit: Homotrimer. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional
isoform 1 on the cell surface. Isoform 3 is unlikely form trimers or bind to BAFF receptors
Selected PDB 3D structures from and Proteopedia for TNFSF13B (see all 8):
1JH5 (3D)        1KD7 (3D)        1KXG (3D)        1OQD (3D)        1OQE (3D)        1OSG (3D)    
Secondary accessions: E0ADT7 Q6FHD6 Q7Z5J2
Alternative splicing: 3 isoforms:  Q9Y275-1   Q9Y275-2   Q9Y275-3   

Explore the universe of human proteins at neXtProt for TNFSF13B: NX_Q9Y275

Explore proteomics data for TNFSF13B at MOPED

Post-translational modifications: 

  • The soluble form derives from the membrane form by proteolytic processing1
  • Isoform 2 is not efficiently shed from the membrane unlike isoform 1 (By similarity)1
  • N-glycosylated1
  • Glycosylation2 at Asn124, Asn242

  • See TNFSF13B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139117.1  NP_006564.1  

    ENSEMBL proteins: 
     ENSP00000365048   ENSP00000389540   ENSP00000445334  

    TNFSF13B Human Recombinant Protein Products:

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    R&D Systems Recombinant & Natural Proteins for TNFSF13B (BAFF/BLyS/TNFSF13B)
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    OriGene Purified Proteins for TNFSF13B
    OriGene Protein Over-expression Lysate for TNFSF13B
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    Novus Biologicals TNFSF13B Proteins
    Novus Biologicals TNFSF13B Lysates
    Sino Biological Recombinant Protein for TNFSF13B
    Sino Biological Cell Lysate for TNFSF13B
    ProSpec Recombinant Protein for TNFSF13B
    Browse Proteins at Cloud-Clone Corp.

     
    eBioscience Proteins for TNFSF13B:  
                        Human CD257 (BAFF, BLyS) Recombinant Protein 5 ug

     
    antibodies-online proteins for TNFSF13B (73 products) 

     
    antibodies-online peptides for TNFSF13B

    TNFSF13B Antibody Products:

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    Novus Biologicals TNFSF13B Antibodies
    Abcam antibodies for TNFSF13B
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for TNFSF13B
    antibodies-online antibodies for TNFSF13B (180 products) 

    TNFSF13B Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for TNFSF13B (BAFF/BLyS/TNFSF13B)         (see all)
    GenScript Custom Assay Services for TNFSF13B
    Enzo Life Sciences assays for TNFSF13B
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for TNFSF13B:  
                        Human BAFF Instant ELISA 128 tests
    antibodies-online kits for TNFSF13B (34 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFSF: Tumor necrosis factor (ligand) superfamily

    2 InterPro protein domains:
     IPR006052 TNF_dom
     IPR008983 Tumour_necrosis_fac-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y275

    ProtoNet protein and cluster: Q9Y275

    1 Blocks protein domain: IPB006052 Tumor Necrosis Factor

    UniProtKB/Swiss-Prot: TN13B_HUMAN, Q9Y275
    Similarity: Belongs to the tumor necrosis factor family


    Find genes that share domains with TNFSF13B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TN13B_HUMAN, Q9Y275
    Function: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors.
    Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and
    the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of
    mature B-cells and the B-cell response
    Function: Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity)
    Function: Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50
    subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for
    soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or
    indirectly regulate the differential expression of a large number of genes involved in the innate immune response
    and the regulation of apoptosis
    Induction: Up-regulated by exposure to IFNG/IFN-gamma. Down-regulated by phorbol myristate acetate/ionomycin
    treatment

         Genatlas biochemistry entry for TNFSF13B:
    tumor necrosis factor (ligand) superfamily,member 13B,expressed abundantly in peripheral blood leukocytes T cell
    and dendritic cells and weakly in spleen,inducing the proliferation of anti IgM stimulated peripheral blood B
    lymphocyte

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS10908663
    GO:0005125cytokine activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding IPI10801128
         
    Find genes that share ontologies with TNFSF13B           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tnfsf13b):
     hematopoietic system  immune system 

    Find genes that share phenotypes with TNFSF13B           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TNFSF13B

    miRNA
    Products:
        
    miRTarBase miRNAs that target TNFSF13B:
    hsa-mir-215-5p (MIRT024564), hsa-mir-192-5p (MIRT026689)

    Block miRNA regulation of human, mouse, rat TNFSF13B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNFSF13B (see all 26):
    hsa-miR-2052 hsa-miR-4291 hsa-miR-19b-2* hsa-miR-15a hsa-miR-503 hsa-miR-578 hsa-miR-424 hsa-miR-7-1*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TNFSF13B

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for TNFSF13B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TNFSF13B (NM_006573)
    Sino Biological Human cDNA Clone for TNFSF13B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFSF13B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF13B

    Cell Line
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TN13B_HUMAN, Q9Y275: Cell membrane; Single-pass type II membrane protein
    TN13B_HUMAN, Q9Y275: Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol2
    nucleus2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane NAS12867412

    Find genes that share ontologies with TNFSF13B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFSF13B About   (see all 15)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    3RANK Signaling in Osteoclasts
    BAFF in B-Cell Signaling0.92
    Apoptosis and survival APRIL and BAFF signaling0.39
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60


    Find genes that share SuperPaths with TNFSF13B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFSF13B
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFSF13B (see all 29)
        TRAF Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions

    1 Cell Signaling Technology (CST) Pathway for TNFSF13B
        Lymphocyte Signaling

    2 GeneGo (Thomson Reuters) Pathways for TNFSF13B
        Apoptosis and survival APRIL and BAFF signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    1 BioSystems Pathway for TNFSF13B
        Spinal Cord Injury

    3 Sino Biological Pathways for TNFSF13B
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    4 Kegg Pathways  (Kegg details for TNFSF13B):
        Cytokine-cytokine receptor interaction
    NF-kappa B signaling pathway
    Intestinal immune network for IgA production
    Rheumatoid arthritis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFSF13B (see all 7): 
              Inflammatory Cytokines & Receptors in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Lymphoma in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFSF13B

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for TNFSF13B (Q9Y2751, 3 ENSP000003650484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF13BO148361, 3, ENSP000002616524EBI-519169,EBI-519160 I2D: score=4 STRING: ENSP00000261652
    TNFRSF13CQ96RJ33, ENSP000002912324I2D: score=3 STRING: ENSP00000291232
    TNFSF13O758883, ENSP000003435054I2D: score=3 STRING: ENSP00000343505
    TNFRSF17Q022233, ENSP000000532434I2D: score=4 STRING: ENSP00000053243
    DTLENSP000003559584STRING: ENSP00000355958
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001782B cell homeostasis IEA--
    GO:0002636positive regulation of germinal center formation IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS10908663
    GO:0008283cell proliferation TAS10908663

    Find genes that share ontologies with TNFSF13B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFSF13B (TN13B)

    3 DrugBank Compounds for TNFSF13B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1,4-Diethylene Dioxide-- --target--17139284 17016423
    Citric Acid-- 77-92-9target--17139284 17016423
    Belimumab -- 356547-88-1targetneutralizer--

    7 Novoseek inferred chemical compound relationships for TNFSF13B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bcma 97.2 84 15697217 (6), 10908663 (5), 14764606 (5), 16960154 (4) (see all 46)
    blys 96.4 208 11133761 (10), 12621010 (9), 19731825 (7), 10398604 (7) (see all 59)
    rituximab 66.3 22 19088870 (3), 17092341 (3), 18510703 (3), 19282839 (2) (see all 10)
    thymidine 0 1 11714784 (1)
    calcium 0 10 19737141 (1), 16818641 (1), 15070697 (1), 15908449 (1) (see all 9)
    alanine 0 2 17584580 (1), 14764606 (1)
    creatinine 0 1 18628284 (1)

    1 PharmGKB related drug/compound annotation for TNFSF13B gene    About this table
    Drug/compound PharmGKB Annotation
    belimumab



    Find genes that share compounds with TNFSF13B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNFSF13B gene (2 alternative transcripts): 
    NM_001145645.2  NM_006573.4  

    Unigene Cluster for TNFSF13B:

    Tumor necrosis factor (ligand) superfamily, member 13b
    Hs.525157  [show with all ESTs]
    Unigene Representative Sequence: NM_006573
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486502 ENST00000375887 ENST00000479435(uc001vqs.1) ENST00000493765
    ENST00000430559(uc001vqr.3 uc010agj.3) ENST00000542136
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TNFSF13B (see all 26):
    hsa-miR-2052 hsa-miR-4291 hsa-miR-19b-2* hsa-miR-15a hsa-miR-503 hsa-miR-578 hsa-miR-424 hsa-miR-7-1*
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    eBioscience FlowRNA Probe Sets ( VA1-12860 VA4-12695) for TNFSF13B 

    Additional mRNA sequence: 

    AF116456.1 AF132600.1 AF134715.1 AF136293.1 AF186114.1 AK309629.1 AY129225.1 AY129226.1 
    AY129227.1 AY129228.1 AY302751.1 AY358881.1 BC020674.1 CR541818.1 DQ857727.1 DQ857728.1 
    HM636064.1 

    6 DOTS entries:

    DT.207328  DT.99956687  DT.101982692  DT.100023471  DT.92424206  DT.92424207 

    Selected AceView cDNA sequences (see all 49):

    BI832664 AA906714 AF150302 CR541818 BC020674 AY302751 AY358881 AF116456 
    AF132600 BM931041 AY129225 AF134715 NM_006573 BX646857 AF186114 BI818459 
    BG571258 BX482686 AV712496 BU929119 BP367030 AF136293 AV712599 BI912461 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF13B    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                -                           
    SP2:                          -     -                           
    SP3:                                                            
    SP4:                                -                           


    ECgene alternative splicing isoforms for TNFSF13B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFSF13B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTAGCTA
    TNFSF13B Expression
    About this image


    TNFSF13B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TNFSF13B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFSF13B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525157

    UniProtKB/Swiss-Prot: TN13B_HUMAN, Q9Y275
    Tissue specificity: Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes
    and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower
    expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many
    myeloid cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFSF13B (see all 7): 
              Inflammatory Cytokines & Receptors in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Lymphoma in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFSF13B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfsf13b1 , 5 tumor necrosis factor (ligand) superfamily, member 13b less1, 5 71.82(n)1
    71.32(a)1
      8 (4.55 cM)5
    240991  NM_033622.11  NP_296371.11 
     100068435 
    chicken
    (Gallus gallus)
    Aves TNFSF13B1 tumor necrosis factor (ligand) superfamily, member 13b less 62.63(n)
    56.06(a)
      374229  NM_204327.2  NP_989658.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNFSF13B6
    tumor necrosis factor (ligand) superfamily, member...
    53(a)
    1 ↔ 1
    1(137085895-137094925)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tnfsf13b1 tumor necrosis factor (ligand) superfamily, member 13b less 58.41(n)
    50.46(a)
      101731546  XM_004912372.1  XP_004912429.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tnfsf13b1 tumor necrosis factor (ligand) superfamily, member 13b less 54.13(n)
    46.33(a)
      561268  NM_001113590.1  NP_001107062.1 


    ENSEMBL Gene Tree for TNFSF13B (if available)
    TreeFam Gene Tree for TNFSF13B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNFSF13B gene
    TNFSF12-TNFSF132  TNFSF122  TNFSF132  
    1 SIMAP similar gene for TNFSF13B using alignment to 4 protein entries:     TN13B_HUMAN (see all proteins):
    TNFSF13

    Find genes that share paralogs with TNFSF13B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFSF13B (see all 873)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1510831481,2
    --89511112(+) AACAGC/TGTGGA 2 -- us2k10--------
    rs1468937631,2
    --89511252(+) TCACAA/TCTGCA 2 -- us2k10--------
    rs1479672101,2
    --89511371(+) ATGTTC/TGCATC 2 -- us2k10--------
    rs1886241821,2
    C--89511450(+) TGTTCC/TAACTC 2 -- us2k10--------
    rs1469375811,2
    --89511680(+) AAATAA/TTTTTT 2 -- us2k10--------
    rs169721941,2
    C,F,H--89511926(+) ACTGTG/ATGGAA 2 -- us2k119Minor allele frequency- A:0.07NA MN EA NS WA 1906
    rs362065101,2
    C--89511974(+) GTCCAC/TAGGGG 2 -- us2k10--------
    rs1494748331,2
    --89511987(+) TAGTGA/GCTACC 2 -- us2k10--------
    rs1430905761,2
    --89512046(+) TTTCAA/GTGCTG 2 -- us2k10--------
    rs777232011,2
    C--89512102(+) AGGATA/GAGGCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TNFSF13B (108903588 - 108960832 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TNFSF13B:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv379e199CNV Deletion23128226
    esv2747975CNV Deletion23290073
    esv2747976CNV Deletion23290073
    esv2563318CNV Insertion19546169
    nsv510624CNV Loss20534489
    esv27365CNV Loss19812545
    nsv526850CNV Gain19592680

    Human Gene Mutation Database (HGMD): TNFSF13B
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing TNFSF13B:
    Glioma
    SeqTarget long-range PCR primers for resequencing TNFSF13B
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFSF13B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 603969    OMIM disorders: --

    10 diseases for TNFSF13B:    
    About MalaCards
    sialadenitis    chronic lymphocytic leukemia    localized scleroderma    familial chronic lymphocytic leukemia
    pediatric systemic lupus erythematosus    pemphigus vulgaris    common variable immunodeficiency    myasthenia gravis
    plasmodium vivax malaria    systemic lupus erythematosus

    6 diseases from the University of Copenhagen DISEASES database for TNFSF13B:
    Systemic lupus erythematosus     Rheumatoid arthritis     Lymphoma     Nephritis
    Sjogren's syndrome     Common variable immunodeficiency

    Find genes that share disorders with TNFSF13B           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TNFSF13B gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 79.6 117 18395853 (3), 19737141 (3), 19507632 (3), 16863659 (3) (see all 63)
    autoimmunity 74.2 55 17029886 (3), 17171221 (3), 15790349 (3), 18395853 (2) (see all 33)
    lupus erythematosus systemic 73.5 61 17506477 (2), 18718031 (2), 17500077 (2), 19565488 (2) (see all 33)
    necrosis 70.7 222 10880535 (2), 18243342 (2), 17500077 (2), 17220480 (2) (see all 99)
    common variable immunodeficiency 63.1 4 14597212 (1), 17689597 (1), 18051214 (1), 17556024 (1)
    sjogrens syndrome primary 61.1 4 16093833 (1), 16014518 (1), 18617551 (1), 15981083 (1)
    rheumatoid arthritis 55.1 43 19291304 (3), 17963166 (2), 18528969 (2), 17092341 (2) (see all 19)
    lymphoma b-cell 53 3 18510703 (2), 18628489 (1)
    tumors 49.9 183 12621010 (4), 10880535 (2), 18243342 (2), 16818641 (2) (see all 99)
    leukemia lymphocytic chronic 48.1 18 17768131 (2), 18556064 (2), 19291294 (1), 15860672 (1) (see all 7)

    Genetic Association Database (GAD): TNFSF13B
    Human Genome Epidemiology (HuGE) Navigator: TNFSF13B (15 documents)

    Export disorders for TNFSF13B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFSF13B gene, integrated from 10 sources (see all 507):
    (articles sorted by number of sources associating them with TNFSF13B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. (PubMed id 10359578)1, 2, 3, 9 Schneider P....Tschopp J. (J. Exp. Med. 1999)
    2. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. (PubMed id 10331498)1, 2, 3 Shu H.-B.... Johnson H. (J. Leukoc. Biol. 1999)
    3. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. (PubMed id 10398604)1, 2, 9 Moore P.A.... Hilbert D.M. (Science 1999)
    4. Genetic variation in B-cell-activating factor is associated with an increased risk of developing B-cell non-Hodgkin lymphoma. (PubMed id 19383901)1, 4, 9 Novak A.J....Ansell S.M. (Cancer Res. 2009)
    5. Analysis on the association of human BLYS (BAFF, TNFSF13B) polymorphisms with systemic lupus erythematosus and rheumatoid arthritis. (PubMed id 12424625)1, 4, 9 Kawasaki A....Tokunaga K. (Genes Immun. 2002)
    6. DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF. (PubMed id 12867412)1, 2, 9 Gavin A.L.... Nemazee D. (J. Biol. Chem. 2003)
    7. No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary SjAPgren's syndrome. (PubMed id 16507129)1, 4, 9 Gottenberg J.E....Miceli-Richard C. (amp 2006)
    8. Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes. (PubMed id 11827482)1, 2, 9 Karpusas M.... Kalled S.L. (J. Mol. Biol. 2002)
    9. The complexity of the BAFF TNF-family members: implications for autoimmunity. (PubMed id 22749832)1, 2 Lahiri A.... Pers J.O. (J. Autoimmun. 2012)
    10. Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies. (PubMed id 20813000)1, 4 Shen M....Zheng T. (Br. J. Haematol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10673 HGNC: 11929 AceView: TNFSF13B Ensembl:ENSG00000102524 euGenes: HUgn10673
    ECgene: TNFSF13B Kegg: 10673 H-InvDB: TNFSF13B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNFSF13B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFSF13B Genetics and Cytogenetics in Oncology and Haematology
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/077

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFSF13B gene:
    Search GeneIP for patents involving TNFSF13B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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