Aliases for TNFSF13B Gene
- TNF Superfamily Member 13b 2 3 5
- Tumor Necrosis Factor (Ligand) Superfamily, Member 13b 2 3
- Dendritic Cell-Derived TNF-Like Molecule 3 4
- B-Cell-Activating Factor 3 4
- TNFSF20 3 4
- TALL-1 3 4
- TALL1 3 4
- ZTNF4 3 4
- BAFF 3 4
- BLYS 3 4
- Tumor Necrosis Factor (Ligand) Superfamily, Member 20 3
- Tumor Necrosis Factor Ligand Superfamily Member 13B 3
- TNF- And APOL-Related Leukocyte Expressed Ligand 1 4
- TNF And ApoL-Related Leukocyte Expressed Ligand 1 3
- Tumor Necrosis Factor Superfamily Member 13b 3
External Ids for TNFSF13B Gene
Previous HGNC Symbols for TNFSF13B Gene
Previous GeneCards Identifiers for TNFSF13B Gene
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
GeneCards Summary for TNFSF13B Gene
TNFSF13B (TNF Superfamily Member 13b) is a Protein Coding gene. Diseases associated with TNFSF13B include Sialadenitis and Hypersensitivity Reaction Type Ii Disease. Among its related pathways are RANK Signaling in Osteoclasts and Akt Signaling. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF12-TNFSF13.
UniProtKB/Swiss-Prot for TNFSF13B Gene
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.
Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.