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TNFSF13 Gene

protein-coding   GIFtS: 68
GCID: GC17P007461

Tumor Necrosis Factor (Ligand) Superfamily, Member 13

  See TNFSF13-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tumor Necrosis Factor (Ligand) Superfamily, Member 131 2     TNF- And APOL-Related Leukocyte Expressed Ligand 22 3
A Proliferation-Inducing Ligand2 3     CD2562
APRIL2 3     Tumor Necrosis Factor Ligand Superfamily Member 132
TALL-22 3     Tumor Necrosis Factor-Like Protein ZTNF22
TALL22 3     Tumor Necrosis Factor-Related Death Ligand-12
TRDL-12 3     CD256 Antigen3
ZTNF22 3     TNF-Related Death Ligand 13

External Ids:    HGNC: 119281   Entrez Gene: 87412   Ensembl: ENSG000001619557   OMIM: 6044725   UniProtKB: O758883   
ORGUL members:         

Export aliases for TNFSF13 gene to outside databases

Previous GC identifers: GC17P007876 GC17P008201 GC17P007396 GC17P007653 GC17P007654 GC17P007397 GC17P007398 GC17P007399 GC17P007402 GC17P007392 GC17P007355


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFSF13 Gene:
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a
ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be
important for B cell development. In vitro experiments suggested that this protein may be able to induce
apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM.
Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the
upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through
transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. (provided by RefSeq, Oct 2010)

GeneCards Summary for TNFSF13 Gene:
TNFSF13 (tumor necrosis factor (ligand) superfamily, member 13) is a protein-coding gene. Diseases associated with TNFSF13 include brain glioblastoma multiforme, and glioblastoma multiforme. GO annotations related to this gene include tumor necrosis factor receptor binding and receptor binding. An important paralog of this gene is TNFSF12-TNFSF13.

UniProtKB/Swiss-Prot: TNF13_HUMAN, O75888
Function: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell
growth. May be involved in monocyte/macrophage-mediated immunological processes

Gene Wiki entry for TNFSF13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFSF13 gene promoter:
         CREB   PPAR-gamma1   AP-1   deltaCREB   MyoD   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TNFSF13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFSF13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

TNFSF13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFSF13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007461:  view genomic region     (about GC identifiers)

Start:
7,461,609 bp from pter      End:
7,464,925 bp from pter
Size:
3,317 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TNF13_HUMAN, O75888 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 13 precursor  
Size: 250 amino acids; 27433 Da
Subunit: Homotrimer (Potential)
Secondary accessions: A8MYD5 B4DVT2 Q541E1 Q5U0G8 Q96HV6 Q9P1M8 Q9P1M9
Alternative splicing: 6 isoforms:  O75888-1   O75888-2   O75888-3   O75888-4   O43508-2   O75888-5   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for TNFSF13: NX_O75888

Explore proteomics data for TNFSF13 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by furin1
  • Glycosylation2 at Asn124
  • Modification sites at PhosphoSitePlus

  • See TNFSF13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001185551.1  NP_001185552.1  NP_001185553.1  NP_003799.1  NP_742084.1  NP_742085.1  

    ENSEMBL proteins: 
     ENSP00000464998   ENSP00000379792   ENSP00000390771   ENSP00000410094   ENSP00000314455  
     ENSP00000343505   ENSP00000379794   ENSP00000369908  
    Reactome Protein details: O75888

    TNFSF13 Human Recombinant Protein Products:

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    Novus Biologicals TNFSF13 Proteins
    Novus Biologicals TNFSF13 Lysates
    Sino Biological Recombinant Protein for TNFSF13
    Sino Biological Cell Lysate for TNFSF13
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNFSF13

     
    Search eBioscience for Proteins for TNFSF13 

     
    antibodies-online proteins for TNFSF13 (31 products) 

     
    antibodies-online peptides for TNFSF13

    TNFSF13 Antibody Products:

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    TNFSF13 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFSF: Tumor necrosis factor (ligand) superfamily

    3 InterPro protein domains:
     IPR006052 TNF_dom
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR021184 TNF_CS

    Graphical View of Domain Structure for InterPro Entry O75888

    ProtoNet protein and cluster: O75888

    1 Blocks protein domain: IPB006052 Tumor Necrosis Factor

    UniProtKB/Swiss-Prot: TNF13_HUMAN, O75888
    Similarity: Belongs to the tumor necrosis factor family


    Find genes that share domains with TNFSF13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNF13_HUMAN, O75888
    Function: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell
    growth. May be involved in monocyte/macrophage-mediated immunological processes
    Induction: Down-regulated by phorbol myristate acetate/ionomycin treatment

         Genatlas biochemistry entry for TNFSF13:
    tumor necrosis factor,ligand,superfamily,member 13,highly expressed in transformed cell lines and in diverse human
    cancers putative regulator of tumor cell growth

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS9743536
    GO:0005125cytokine activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TNFSF13           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNFSF13:
     G0/1 arrest  Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tnfsf13):
     hematopoietic system  immune system  normal  skeleton 

    Find genes that share phenotypes with TNFSF13           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TNFSF13: Tnfsf13tm1Pod Tnfsf13tm1Ash Tnfsf13tm1Geha

       genOway: Develop your customized and physiologically relevant rodent model for TNFSF13

    miRNA
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    miRTarBase miRNAs that target TNFSF13:
    hsa-mir-375 (MIRT019711), hsa-mir-192-5p (MIRT026351)

    Block miRNA regulation of human, mouse, rat TNFSF13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNFSF13 (see all 10):
    hsa-miR-516b hsa-miR-26b* hsa-miR-1270 hsa-miR-3158-3p hsa-miR-199a-5p hsa-miR-620 hsa-miR-199b-5p hsa-miR-145
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TNFSF13

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 6): TNFSF13 (NM_001198622)
    Sino Biological Human cDNA Clone for TNFSF13
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF13

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNF13_HUMAN, O75888: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol4
    nucleus4
    plasma membrane2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0009897external side of plasma membrane IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with TNFSF13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFSF13 About   (see all 13)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    3RANK Signaling in Osteoclasts
    APRIL Pathway0.92
    Apoptosis and survival APRIL and BAFF signaling0.39
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    5CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.62
    Stabilization of mRNA by HuR0.00


    Find genes that share SuperPaths with TNFSF13           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFSF13
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFSF13 (see all 18)
        TRAF Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    APRIL Pathway

    3 GeneGo (Thomson Reuters) Pathways for TNFSF13
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival APRIL and BAFF signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    1 BioSystems Pathway for TNFSF13
        Spinal Cord Injury

    3 Sino Biological Pathways for TNFSF13
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    1 Reactome Pathway for TNFSF13
        HuR stabilizes mRNA


    3 Kegg Pathways  (Kegg details for TNFSF13):
        Cytokine-cytokine receptor interaction
    Intestinal immune network for IgA production
    Rheumatoid arthritis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFSF13: 
              Inflammatory Cytokines & Receptors in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFSF13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for TNFSF13 (O758883 ENSP000003435054) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF13BO148363, ENSP000002616524I2D: score=3 STRING: ENSP00000261652
    FASP254453, ENSP000003479794I2D: score=2 STRING: ENSP00000347979
    TNFRSF11BO003003, ENSP000002973504I2D: score=2 STRING: ENSP00000297350
    TNFRSF14Q929563, ENSP000003479484I2D: score=2 STRING: ENSP00000347948
    FURINP099583, ENSP000002681714I2D: score=1 STRING: ENSP00000268171
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002426immunoglobulin production in mucosal tissue IEA--
    GO:0002636positive regulation of germinal center formation IEA--
    GO:0006955immune response ----
    GO:0007165signal transduction TAS9743536
    GO:0008284positive regulation of cell proliferation IEA--

    Find genes that share ontologies with TNFSF13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFSF13 (TNF13)

    3 Novoseek inferred chemical compound relationships for TNFSF13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bcma 97.6 62 14764606 (6), 16960154 (4), 17968879 (4), 15697217 (3) (see all 33)
    blys 93.8 81 16239971 (6), 12370363 (5), 12687540 (5), 12351410 (4) (see all 22)
    monopril 88 5 19997650 (2), 17021878 (1), 16094704 (1)



    Find genes that share compounds with TNFSF13           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNFSF13 gene (6 alternative transcripts): 
    NM_001198622.1  NM_001198623.1  NM_001198624.1  NM_003808.3  NM_172087.2  NM_172088.2  

    Unigene Cluster for TNFSF13:

    Tumor necrosis factor (ligand) superfamily, member 13
    Hs.54673  [show with all ESTs]
    Unigene Representative Sequence: NM_003808
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483039 ENST00000396542 ENST00000438470 ENST00000436057 ENST00000349228(uc002ghj.2 uc002ghk.2 uc002ghl.2 uc010vua.1 uc010cmk.2)
    ENST00000338784(uc021tpb.1) ENST00000396545 ENST00000380535
    miRNA
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    hsa-miR-516b hsa-miR-26b* hsa-miR-1270 hsa-miR-3158-3p hsa-miR-199a-5p hsa-miR-620 hsa-miR-199b-5p hsa-miR-145
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    Primer
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    Additional mRNA sequence: 

    AF030099.1 AF046888.1 AF055872.1 AF114011.1 AF114012.1 AF114013.1 AF136294.1 AF184972.1 
    AK090698.1 AK225556.1 AK301221.1 AK314518.1 AY081050.1 AY358870.1 AY358880.1 AY377858.1 
    BC008042.2 BC104420.1 BT019561.1 BT019562.1 CR542040.1 CR542073.1 DQ149579.1 EF211088.1 
    NR_037146.1 NR_073490.2 

    13 DOTS entries:

    DT.443031  DT.91764994  DT.100754772  DT.210127  DT.97846269  DT.97846267  DT.100817918  DT.91765000 
    DT.97773298  DT.100817915  DT.95258824  DT.95376400  DT.120916384 

    Selected AceView cDNA sequences (see all 342):

    CB528323 BQ073114 CD366782 BM974244 AF136294 AI581741 AI422796 BM712014 
    AW195034 AI868964 AI378132 AI127694 BI758093 AA424562 CA396679 AA364051 
    AI954750 AY377858 AI310092 AF114012 CA866073 AA394047 BM670282 AI432668 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF13 (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^
    SP1:              -                       -           -     -     -     -     -     -     -     -     -     -     -                                             
    SP2:              -                                                                                                                                             
    SP3:                                                                                                                                                            
    SP4:              -                       -                                                                                                                     
    SP5:              -                       -                                                                                                                     

    ExUns: 16a · 16b ^ 17a · 17b · 17c · 17d
    SP1:                                    
    SP2:                                    
    SP3:        -                           
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for TNFSF13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFSF13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACACCTCT
    TNFSF13 Expression
    About this image


    TNFSF13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
     
     Lung (Respiratory System)
     
     Colon (Gastrointestinal Tract)
    TNFSF13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFSF13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.54673

    UniProtKB/Swiss-Prot: TNF13_HUMAN, O75888
    Tissue specificity: Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid
    tissues and specifically expressed in monocytes and macrophages

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFSF13: 
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              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFSF13 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfsf131 , 5 tumor necrosis factor (ligand) superfamily, member more1, 5 82.22(n)1
    81.25(a)1
      11 (42.86 cM)5
    695831  NM_023517.21  NP_076006.21 
     696828465 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    32(a)
    1 → many
    GL343660.1(16198-37951)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017309411 tumor necrosis factor ligand superfamily member 13-like 49.3(n)
    38.6(a)
      101730941  XM_004919407.1  XP_004919464.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tnfsf136
    tumor necrosis factor (ligand) superfamily, member...
    32(a)
    1 → many
    5(71366008-71376195) ENSDARG00000091556


    ENSEMBL Gene Tree for TNFSF13 (if available)
    TreeFam Gene Tree for TNFSF13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNFSF13 gene
    TNFSF12-TNFSF132  TNFSF13B2  TNFSF122  
    1 SIMAP similar gene for TNFSF13 using alignment to 8 protein entries:     TNF13_HUMAN (see all proteins):
    TNFSF13B

    Find genes that share paralogs with TNFSF13           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFSF13 (see all 169)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1930443231,2
    --7448854(+) GATAGA/GCATTT 7 -- us2k10--------
    rs1478678641,2
    C--7449100(+) GTCAAC/TTATGG 7 -- us2k10--------
    rs1848105571,2
    --7449116(+) ATAGGC/GGATGG 7 -- us2k10--------
    rs2003131931,2
    C--7449212(+) GTGGGG/AGAGTC 7 -- us2k11Minor allele frequency- A:0.00EU 1297
    rs2015825471,2
    F--7449287(+) CTGGGA/GGGAAG 7 -- us2k11Minor allele frequency- G:0.00EU 1069
    rs2000590751,2
    --7449329(+) CAACCA/GCCAGA 7 -- us2k10--------
    rs3696617281,2
    C--7449422(+) TAAGAA/GAGTGG 7 -- us2k10--------
    rs1884949041,2
    --7449447(+) GGAGAG/TTGGGG 7 -- us2k10--------
    rs1414500011,2
    --7449462(+) AGCTAC/TAGGGC 7 -- us2k10--------
    rs38037971,2
    H--7449480(+) GTGAGT/CTGGGG 7 -- us2k14Minor allele frequency- C:0.00NS EA 418

    HapMap Linkage Disequilibrium report for TNFSF13 (7461609 - 7464925 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TNFSF13:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    nsv457659CNV Loss19166990
    nsv907651CNV Loss21882294

    Human Gene Mutation Database (HGMD): TNFSF13
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TNFSF13
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604472    OMIM disorders: --

    3 diseases for TNFSF13:    
    About MalaCards
    brain glioblastoma multiforme    glioblastoma multiforme    b-cell chronic lymphocytic leukemia


    Find genes that share disorders with TNFSF13           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TNFSF13 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 61.5 7 14764606 (1), 19339060 (1), 19758161 (1), 16239971 (1) (see all 7)
    autoimmunity 60.3 4 19760066 (2), 18295728 (1)
    necrosis 59.7 35 11550092 (3), 10956646 (2), 14504101 (1), 16547002 (1) (see all 31)
    lupus erythematosus systemic 43.5 11 18718031 (2), 17307753 (2), 19565488 (2), 17092341 (2) (see all 7)
    leukemia lymphocytic chronic 42.7 9 17768131 (2), 19291294 (1), 17026820 (1), 19452288 (1)
    tumors 36.7 61 11550092 (4), 19291294 (4), 15846369 (4), 9743536 (3) (see all 32)
    hodgkin disease 25.6 7 17315017 (1), 16960154 (1), 19291294 (1), 17026820 (1)
    hematologic malignancies 23 1 19291294 (1)
    rheumatoid arthritis 22.8 7 17092341 (2), 17307753 (1), 17968879 (1), 20116334 (1) (see all 5)
    lymphoma 15.7 4 17026820 (1), 19321861 (1), 19452288 (1)

    Genetic Association Database (GAD): TNFSF13
    Human Genome Epidemiology (HuGE) Navigator: TNFSF13 (9 documents)

    Export disorders for TNFSF13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFSF13 gene, integrated from 10 sources (see all 202):
    (articles sorted by number of sources associating them with TNFSF13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. (PubMed id 9743536)1, 2, 3, 9 Hahne M.... Tschopp J. (J. Exp. Med. 1998)
    2. Role of APRIL (TNFSF13) polymorphisms in the susceptibility to systemic lupus erythematosus in Japanese. (PubMed id 17307753)1, 4, 9 Kawasaki A....Tokunaga K. (Rheumatology (Oxford) 2007)
    3. A novel polymorphism of the human APRIL gene is associated with systemic lupus erythematosus. (PubMed id 12730512)1, 4, 9 Koyama T....Horiuchi T. (Rheumatology (Oxford) 2003)
    4. APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death. (PubMed id 10706119)1, 2, 9 Kelly K.A.... Jones D.A. (Cancer Res. 2000)
    5. An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein. (PubMed id 12411489)1, 2, 9 Pradet-Balade B....Hahne M. (EMBO J. 2002)
    6. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. (PubMed id 22197929)1, 4 Yu X.Q....Liu J.J. (Nat. Genet. 2012)
    7. Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese. (PubMed id 22558069)1, 4 Osman W....Nakamura Y. (PLoS ONE 2012)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    10. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8741 HGNC: 11928 AceView: TNFSF13 Ensembl:ENSG00000161955 euGenes: HUgn8741
    ECgene: TNFSF13 Kegg: 8741 H-InvDB: TNFSF13

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNFSF13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFSF13 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFSF13 gene:
    Search GeneIP for patents involving TNFSF13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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