Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TNFSF12-TNFSF13 Gene

Aliases for TNFSF12-TNFSF13 Gene

  • TNFSF12-TNFSF13 Readthrough 2 3 5
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 12-Member 13 3
  • TNFSF12-TNFSF13 Protein 3
  • TWE-PRIL 3

External Ids for TNFSF12-TNFSF13 Gene

Previous GeneCards Identifiers for TNFSF12-TNFSF13 Gene

  • GC17U900475
  • GC17P007393
  • GC17P007347
  • GC17P007453
  • GC17P007552
  • GC17P007555

Summaries for TNFSF12-TNFSF13 Gene

Entrez Gene Summary for TNFSF12-TNFSF13 Gene

  • This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFSF12-TNFSF13 Gene

TNFSF12-TNFSF13 (TNFSF12-TNFSF13 Readthrough) is a Protein Coding gene. GO annotations related to this gene include cytokine activity and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF13.

Gene Wiki entry for TNFSF12-TNFSF13 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF12-TNFSF13 Gene

Genomics for TNFSF12-TNFSF13 Gene

Regulatory Elements for TNFSF12-TNFSF13 Gene

Enhancers for TNFSF12-TNFSF13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F007474 1.6 FANTOM5 ENCODE 10.7 -68.5 -68469 12.5 CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DVL2 SNORD10 SNORA48 CHRNB1 PFAS LOC105371523 KCTD11 CTC1 CNTROB MIR6883
GH17F007401 1.1 ENCODE 10.4 -144.9 -144933 4.8 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 DVL2 ENSG00000262067 ENSG00000271029 SPEM1 ENSG00000262089 SNORD10 C17orf74 CNTROB CHRNB1 ACAP1
GH17F007465 1 Ensembl ENCODE 11.2 -82.0 -82031 2.2 HDAC1 ESRRA ZNF175 BCL11B YY1 HIC1 NCOR1 POLR2A RCOR1 NR2F6 CHRNB1 FGF11 TMEM102 C17orf74 SPEM1 TNFSF12 TNFSF12-TNFSF13 NLGN2 TMEM256 TMEM256-PLSCR3
GH17F007613 1 ENCODE 10.8 +65.5 65504 2.9 HDGF ATF1 PKNOX1 ARID4B SIN3A YY1 GTF3C2 GLIS2 ZNF143 ZNF548 DVL2 SNORD10 PFAS SNORA48 CTC1 CNTROB LOC105371523 TNFSF12 MIR6883 SOX15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFSF12-TNFSF13 on UCSC Golden Path with GeneCards custom track

Promoters for TNFSF12-TNFSF13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001340234 142 1601 HDGF PKNOX1 KLF17 ARID4B ZNF48 ZNF366 KLF7 EGR2 SP5 ZEB2

Genomic Location for TNFSF12-TNFSF13 Gene

7,549,058 bp from pter
7,561,608 bp from pter
12,551 bases
Plus strand

Genomic View for TNFSF12-TNFSF13 Gene

Genes around TNFSF12-TNFSF13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF12-TNFSF13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF12-TNFSF13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF12-TNFSF13 Gene

Proteins for TNFSF12-TNFSF13 Gene

  • Protein details for TNFSF12-TNFSF13 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein TNFSF12-TNFSF13
    Protein Accession:

    Protein attributes for TNFSF12-TNFSF13 Gene

    330 amino acids
    Molecular mass:
    36589 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TNFSF12-TNFSF13 Gene

Post-translational modifications for TNFSF12-TNFSF13 Gene

No Post-translational modifications

Other Protein References for TNFSF12-TNFSF13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFSF12-TNFSF13 Gene

Domains & Families for TNFSF12-TNFSF13 Gene

Protein Domains for TNFSF12-TNFSF13 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFSF12-TNFSF13: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TNFSF12-TNFSF13 Gene

Function for TNFSF12-TNFSF13 Gene

Gene Ontology (GO) - Molecular Function for TNFSF12-TNFSF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005164 tumor necrosis factor receptor binding IEA --
genes like me logo Genes that share ontologies with TNFSF12-TNFSF13: view

Phenotypes for TNFSF12-TNFSF13 Gene

genes like me logo Genes that share phenotypes with TNFSF12-TNFSF13: view

Animal Model Products

CRISPR Products

Clone Products

Cell Line Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TNFSF12-TNFSF13 Gene

Localization for TNFSF12-TNFSF13 Gene

Gene Ontology (GO) - Cellular Components for TNFSF12-TNFSF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFSF12-TNFSF13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TNFSF12-TNFSF13 Gene

Pathways & Interactions for TNFSF12-TNFSF13 Gene

SuperPathways for TNFSF12-TNFSF13 Gene

No Data Available

Interacting Proteins for TNFSF12-TNFSF13 Gene

Gene Ontology (GO) - Biological Process for TNFSF12-TNFSF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with TNFSF12-TNFSF13: view

No data available for Pathways by source and SIGNOR curated interactions for TNFSF12-TNFSF13 Gene

Transcripts for TNFSF12-TNFSF13 Gene

mRNA/cDNA for TNFSF12-TNFSF13 Gene

(1) REFSEQ mRNAs :
(342) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF12-TNFSF13 Gene

No ASD Table

Relevant External Links for TNFSF12-TNFSF13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFSF12-TNFSF13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFSF12-TNFSF13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expression patterns with TNFSF12-TNFSF13: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TNFSF12-TNFSF13 Gene

Orthologs for TNFSF12-TNFSF13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF12-TNFSF13 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Tnfsf12Tnfsf13 34
  • 85.03 (n)
BC096441 35
  • 68 (a)
Tnfsf12 35
  • 68 (a)
Tnfsfm13 16
(Pan troglodytes)
Mammalia TNFSF12 35
  • 69 (a)
(Canis familiaris)
Mammalia TNFSF12 35
  • 61 (a)
(Bos Taurus)
Mammalia -- 35
  • 57 (a)
(Monodelphis domestica)
Mammalia TNFSF13 35
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 23 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 33 (a)
(Danio rerio)
Actinopterygii tnfsf13 34 35
  • 51.75 (n)
Species where no ortholog for TNFSF12-TNFSF13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFSF12-TNFSF13 Gene

Gene Tree for TNFSF12-TNFSF13 (if available)
Gene Tree for TNFSF12-TNFSF13 (if available)

Paralogs for TNFSF12-TNFSF13 Gene

Paralogs for TNFSF12-TNFSF13 Gene

genes like me logo Genes that share paralogs with TNFSF12-TNFSF13: view

Variants for TNFSF12-TNFSF13 Gene

Sequence variations from dbSNP and Humsavar for TNFSF12-TNFSF13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs540997935 Uncertain significance 7,556,837(+) CTCTG(C/T)GCTAC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs11078696 -- 7,555,982(+) TTTTT(G/T)TTTTT intron-variant
rs111451688 -- 7,560,295(+) AGGCC(C/T)CCCAG intron-variant, upstream-variant-2KB
rs111505625 -- 7,548,141(+) GGTCC(G/T)TCCTT upstream-variant-2KB
rs111806611 -- 7,552,435(+) CGATT(C/G)TCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFSF12-TNFSF13 Gene

Variant ID Type Subtype PubMed ID
nsv574322 CNV loss 21841781
nsv523672 CNV loss 19592680
nsv457659 CNV loss 19166990
esv2422288 CNV deletion 17116639

Variation tolerance for TNFSF12-TNFSF13 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFSF12-TNFSF13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF12-TNFSF13 Gene

Disorders for TNFSF12-TNFSF13 Gene

Relevant External Links for TNFSF12-TNFSF13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TNFSF12-TNFSF13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFSF12-TNFSF13 Gene

Publications for TNFSF12-TNFSF13 Gene

  1. An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein. (PMID: 12411489) Pradet-Balade B. … Hahne M. (EMBO J. 2002) 2 3 22 64
  2. Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese. (PMID: 22558069) Osman W. … Nakamura Y. (PLoS ONE 2012) 3 46 64
  3. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. (PMID: 22197929) Yu X.Q. … Liu J.J. (Nat. Genet. 2012) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Role of APRIL (TNFSF13) polymorphisms in the susceptibility to systemic lupus erythematosus in Japanese. (PMID: 17307753) Kawasaki A. … Tokunaga K. (Rheumatology (Oxford) 2007) 3 22 64

Products for TNFSF12-TNFSF13 Gene

Sources for TNFSF12-TNFSF13 Gene

Loading form....