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Aliases for TNFSF12-TNFSF13 Gene

Aliases for TNFSF12-TNFSF13 Gene

  • TNFSF12-TNFSF13 Readthrough 2 3
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 12-Member 13 3
  • TNFSF12-TNFSF13 Protein 3
  • TWE-PRIL 3

External Ids for TNFSF12-TNFSF13 Gene

Previous GeneCards Identifiers for TNFSF12-TNFSF13 Gene

  • GC17U900475
  • GC17P007393
  • GC17P007347
  • GC17P007453

Summaries for TNFSF12-TNFSF13 Gene

Entrez Gene Summary for TNFSF12-TNFSF13 Gene

  • This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFSF12-TNFSF13 Gene

TNFSF12-TNFSF13 (TNFSF12-TNFSF13 Readthrough) is a Protein Coding gene. Diseases associated with TNFSF12-TNFSF13 include rheumatic disease. Among its related pathways are Gene Expression and TWEAK Pathway. An important paralog of this gene is TNFSF13.

Gene Wiki entry for TNFSF12-TNFSF13 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF12-TNFSF13 Gene

Genomics for TNFSF12-TNFSF13 Gene

Regulatory Elements for TNFSF12-TNFSF13 Gene

Genomic Location for TNFSF12-TNFSF13 Gene

7,549,058 bp from pter
7,561,608 bp from pter
12,551 bases
Plus strand

Genomic View for TNFSF12-TNFSF13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFSF12-TNFSF13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF12-TNFSF13 Gene

Proteins for TNFSF12-TNFSF13 Gene

  • Protein details for TNFSF12-TNFSF13 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein TNFSF12-TNFSF13
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TNFSF12-TNFSF13 Gene

    330 amino acids
    Molecular mass:
    36589 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TNFSF12-TNFSF13 Gene

Proteomics data for TNFSF12-TNFSF13 Gene at MOPED

Post-translational modifications for TNFSF12-TNFSF13 Gene

No Post-translational modifications

Other Protein References for TNFSF12-TNFSF13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFSF12-TNFSF13 Gene

Domains for TNFSF12-TNFSF13 Gene

Protein Domains for TNFSF12-TNFSF13 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFSF12-TNFSF13: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TNFSF12-TNFSF13 Gene

Function for TNFSF12-TNFSF13 Gene

Gene Ontology (GO) - Molecular Function for TNFSF12-TNFSF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity --
GO:0005164 tumor necrosis factor receptor binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TNFSF12-TNFSF13: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TNFSF12-TNFSF13 Gene

Localization for TNFSF12-TNFSF13 Gene

Gene Ontology (GO) - Cellular Components for TNFSF12-TNFSF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with TNFSF12-TNFSF13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TNFSF12-TNFSF13 Gene

Pathways for TNFSF12-TNFSF13 Gene

genes like me logo Genes that share pathways with TNFSF12-TNFSF13: view

Pathways by source for TNFSF12-TNFSF13 Gene

1 BioSystems pathway for TNFSF12-TNFSF13 Gene

Interacting Proteins for TNFSF12-TNFSF13 Gene

Gene Ontology (GO) - Biological Process for TNFSF12-TNFSF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response --
genes like me logo Genes that share ontologies with TNFSF12-TNFSF13: view

Transcripts for TNFSF12-TNFSF13 Gene

mRNA/cDNA for TNFSF12-TNFSF13 Gene

(342) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFSF12-TNFSF13

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF12-TNFSF13 Gene

No ASD Table

Relevant External Links for TNFSF12-TNFSF13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFSF12-TNFSF13 Gene

mRNA expression in normal human tissues for TNFSF12-TNFSF13 Gene

genes like me logo Genes that share expressions with TNFSF12-TNFSF13: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TNFSF12-TNFSF13 Gene

Orthologs for TNFSF12-TNFSF13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF12-TNFSF13 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Tnfsf12Tnfsf13 35
  • 85.03 (n)
  • 83.83 (a)
BC096441 16
BC096441 36
  • 68 (a)
Tnfsf12 36
  • 68 (a)
(Bos Taurus)
Mammalia -- 36
  • 57 (a)
(Canis familiaris)
Mammalia TNFSF12 36
  • 61 (a)
(Monodelphis domestica)
Mammalia TNFSF13 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 23 (a)
(Pan troglodytes)
Mammalia TNFSF12 36
  • 69 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
(Danio rerio)
Actinopterygii tnfsf13 35
  • 51.75 (n)
  • 41.45 (a)
tnfsf13 36
  • 33 (a)
Species with no ortholog for TNFSF12-TNFSF13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFSF12-TNFSF13 Gene

Gene Tree for TNFSF12-TNFSF13 (if available)
Gene Tree for TNFSF12-TNFSF13 (if available)

Paralogs for TNFSF12-TNFSF13 Gene

Paralogs for TNFSF12-TNFSF13 Gene

genes like me logo Genes that share paralogs with TNFSF12-TNFSF13: view

Variants for TNFSF12-TNFSF13 Gene

Structural Variations from Database of Genomic Variants (DGV) for TNFSF12-TNFSF13 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv523672 CNV Loss 19592680
nsv907651 CNV Loss 21882294

Relevant External Links for TNFSF12-TNFSF13 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TNFSF12-TNFSF13 Gene

Disorders for TNFSF12-TNFSF13 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TNFSF12-TNFSF13 Gene in MalaCards »

(1) Diseases for TNFSF12-TNFSF13 Gene including...

Relevant External Links for TNFSF12-TNFSF13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TNFSF12-TNFSF13: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TNFSF12-TNFSF13 Gene

Publications for TNFSF12-TNFSF13 Gene

  1. An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein. (PMID: 12411489) Pradet-Balade B. … Hahne M. (EMBO J. 2002) 2 3 23
  2. Role of APRIL (TNFSF13) polymorphisms in the susceptibility to systemic lupus erythematosus in Japanese. (PMID: 17307753) Kawasaki A. … Tokunaga K. (Rheumatology (Oxford) 2007) 3 23
  3. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. (PMID: 22197929) Yu X.Q. … Liu J.J. (Nat. Genet. 2012) 3 48
  4. Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese. (PMID: 22558069) Osman W. … Nakamura Y. (PLoS ONE 2012) 3 48
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for TNFSF12-TNFSF13 Gene

Sources for TNFSF12-TNFSF13 Gene

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