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Aliases for TNFSF12-TNFSF13 Gene

Aliases for TNFSF12-TNFSF13 Gene

  • TNFSF12-TNFSF13 Readthrough 2 3 5
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 12-Member 13 3
  • TWE-PRIL 3

External Ids for TNFSF12-TNFSF13 Gene

Previous GeneCards Identifiers for TNFSF12-TNFSF13 Gene

  • GC17U900475
  • GC17P007393
  • GC17P007347
  • GC17P007453
  • GC17P007552

Summaries for TNFSF12-TNFSF13 Gene

Entrez Gene Summary for TNFSF12-TNFSF13 Gene

  • This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFSF12-TNFSF13 Gene

TNFSF12-TNFSF13 (TNFSF12-TNFSF13 Readthrough) is a Protein Coding gene. Among its related pathways are TWEAK Pathway. GO annotations related to this gene include cytokine activity and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF13.

Gene Wiki entry for TNFSF12-TNFSF13 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF12-TNFSF13 Gene

Genomics for TNFSF12-TNFSF13 Gene

Regulatory Elements for TNFSF12-TNFSF13 Gene

Promoters for TNFSF12-TNFSF13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNFSF12-TNFSF13 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNFSF12-TNFSF13 Gene

Chromosome:
17
Start:
7,549,058 bp from pter
End:
7,561,608 bp from pter
Size:
12,551 bases
Orientation:
Plus strand

Genomic View for TNFSF12-TNFSF13 Gene

Genes around TNFSF12-TNFSF13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF12-TNFSF13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF12-TNFSF13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF12-TNFSF13 Gene

Proteins for TNFSF12-TNFSF13 Gene

  • Protein details for TNFSF12-TNFSF13 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YY99
    Recommended name:
    Protein TNFSF12-TNFSF13
    Protein Accession:
    A0A0A6YY99

    Protein attributes for TNFSF12-TNFSF13 Gene

    Size:
    330 amino acids
    Molecular mass:
    36589 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TNFSF12-TNFSF13 Gene

Proteomics data for TNFSF12-TNFSF13 Gene at MOPED

Post-translational modifications for TNFSF12-TNFSF13 Gene

No Post-translational modifications

Other Protein References for TNFSF12-TNFSF13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFSF12-TNFSF13 Gene

Domains & Families for TNFSF12-TNFSF13 Gene

Protein Domains for TNFSF12-TNFSF13 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFSF12-TNFSF13: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TNFSF12-TNFSF13 Gene

Function for TNFSF12-TNFSF13 Gene

Phenotypes for TNFSF12-TNFSF13 Gene

genes like me logo Genes that share phenotypes with TNFSF12-TNFSF13: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TNFSF12-TNFSF13 Gene

Localization for TNFSF12-TNFSF13 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TNFSF12-TNFSF13 Gene

Pathways & Interactions for TNFSF12-TNFSF13 Gene

SuperPathways for TNFSF12-TNFSF13 Gene

Superpath Contained pathways
1 TWEAK Pathway
genes like me logo Genes that share pathways with TNFSF12-TNFSF13: view

Pathways by source for TNFSF12-TNFSF13 Gene

1 BioSystems pathway for TNFSF12-TNFSF13 Gene

Interacting Proteins for TNFSF12-TNFSF13 Gene

Gene Ontology (GO) - Biological Process for TNFSF12-TNFSF13 Gene

None

No data available for SIGNOR curated interactions for TNFSF12-TNFSF13 Gene

Drugs & Compounds for TNFSF12-TNFSF13 Gene

No Compound Related Data Available

Transcripts for TNFSF12-TNFSF13 Gene

mRNA/cDNA for TNFSF12-TNFSF13 Gene

(1) REFSEQ mRNAs :
(342) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF12-TNFSF13 Gene

No ASD Table

Relevant External Links for TNFSF12-TNFSF13 Gene

GeneLoc Exon Structure for
TNFSF12-TNFSF13
ECgene alternative splicing isoforms for
TNFSF12-TNFSF13

Expression for TNFSF12-TNFSF13 Gene

mRNA expression in normal human tissues for TNFSF12-TNFSF13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expression patterns with TNFSF12-TNFSF13: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TNFSF12-TNFSF13 Gene

Orthologs for TNFSF12-TNFSF13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF12-TNFSF13 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Tnfsf12Tnfsf13 35
  • 85.03 (n)
  • 83.83 (a)
Tnfsfm13 16
BC096441 36
  • 68 (a)
ManyToMany
Tnfsf12 36
  • 68 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 57 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia TNFSF12 36
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TNFSF13 36
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 23 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TNFSF12 36
  • 69 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tnfsf13 35
  • 51.75 (n)
  • 41.45 (a)
tnfsf13 36
  • 33 (a)
OneToMany
Species with no ortholog for TNFSF12-TNFSF13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFSF12-TNFSF13 Gene

ENSEMBL:
Gene Tree for TNFSF12-TNFSF13 (if available)
TreeFam:
Gene Tree for TNFSF12-TNFSF13 (if available)

Paralogs for TNFSF12-TNFSF13 Gene

Paralogs for TNFSF12-TNFSF13 Gene

genes like me logo Genes that share paralogs with TNFSF12-TNFSF13: view

Variants for TNFSF12-TNFSF13 Gene

Structural Variations from Database of Genomic Variants (DGV) for TNFSF12-TNFSF13 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv523672 CNV Loss 19592680
nsv907651 CNV Loss 21882294

Variation tolerance for TNFSF12-TNFSF13 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFSF12-TNFSF13 Gene

HapMap Linkage Disequilibrium report
TNFSF12-TNFSF13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TNFSF12-TNFSF13 Gene

Disorders for TNFSF12-TNFSF13 Gene

Relevant External Links for TNFSF12-TNFSF13

Genetic Association Database (GAD)
TNFSF12-TNFSF13
Human Genome Epidemiology (HuGE) Navigator
TNFSF12-TNFSF13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFSF12-TNFSF13

No disorders were found for TNFSF12-TNFSF13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFSF12-TNFSF13 Gene

Publications for TNFSF12-TNFSF13 Gene

  1. An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein. (PMID: 12411489) Pradet-Balade B. … Hahne M. (EMBO J. 2002) 2 3 23 67
  2. Role of APRIL (TNFSF13) polymorphisms in the susceptibility to systemic lupus erythematosus in Japanese. (PMID: 17307753) Kawasaki A. … Tokunaga K. (Rheumatology (Oxford) 2007) 3 23
  3. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. (PMID: 22197929) Yu X.Q. … Liu J.J. (Nat. Genet. 2012) 3
  4. Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese. (PMID: 22558069) Osman W. … Nakamura Y. (PLoS ONE 2012) 3
  5. Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers. (PMID: 22864923) Yang C. … Zengnan M. (Immunogenetics 2012) 3

Products for TNFSF12-TNFSF13 Gene

Sources for TNFSF12-TNFSF13 Gene

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