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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFSF12 Gene

protein-coding   GIFtS: 55
GCID: GC17P007452

Tumor Necrosis Factor (Ligand) Superfamily, Member 12

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Necrosis Factor (Ligand) Superfamily, Member 121 2     TNF-Related Weak Inducer Of Apoptosis2 3
APO3L2 3 5     APO3 Ligand2 3
DR3LG2 3 5     APO3/DR3 Ligand2
TWEAK2 3 5     Tumor Necrosis Factor Ligand Superfamily Member 122

External Ids:    HGNC: 119271   Entrez Gene: 87422   Ensembl: ENSG000002396977   OMIM: 6026955   UniProtKB: O435083   

Export aliases for TNFSF12 gene to outside databases

Previous GC identifers: GC17P007866 GC17P008192 GC17P007395 GC17P007652 GC17P007394 GC17P007401 GC17P007346


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFSF12 Gene:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This
protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but
displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms,
can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also
found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.
Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene
and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in
GeneID 407977, TNFSF12-TNFSF13. (provided by RefSeq, Oct 2010)

GeneCards Summary for TNFSF12 Gene: 
TNFSF12 (tumor necrosis factor (ligand) superfamily, member 12) is a protein-coding gene. Diseases associated with TNFSF12 include chronic graft versus host disease, and hemophagocytic lymphohistiocytosis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and DR3 Signaling. GO annotations related to this gene include tumor necrosis factor receptor binding and receptor binding. An important paralog of this gene is TNFSF12-TNFSF13.

UniProtKB/Swiss-Prot: TNF12_HUMAN, O43508
Function: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates
NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in
induction of inflammatory cytokines

Gene Wiki entry for TNFSF12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFSF12 gene promoter:
         AP-1   ATF-2   FOXO1a   MyoD   c-Jun   NF-kappaB   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TNFSF12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFSF12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

TNFSF12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFSF12 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007452:  view genomic region     (about GC identifiers)

Start:
7,452,208 bp from pter      End:
7,464,925 bp from pter
Size:
12,718 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNF12_HUMAN, O43508 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 12  
Size: 249 amino acids; 27216 Da
Subunit: Homotrimer (Potential). Interacts with the angiogenic factor AGGF1/VG5Q
Subcellular location: Cell membrane; Single-pass type II membrane protein
Subcellular location: Tumor necrosis factor ligand superfamily member 12, secreted form: Secreted
Subcellular location: Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein
Sequence caution: Sequence=AAH19047.1; Type=Frameshift; Positions=125;
1 PDB 3D structure from and Proteopedia for TNFSF12:
4HT1 (3D)    
Secondary accessions: Q8IZK7 Q8WUZ7
Alternative splicing: 2 isoforms:  O43508-1   O43508-2   (Endogenous hybrid transcript between TWEAK and APRIL. Expressed at protein level in primary T-lymphocytes and monocytic cell lines)

Explore the universe of human proteins at neXtProt for TNFSF12: NX_O43508

Explore proteomics data for TNFSF12 at MOPED 

Post-translational modifications:

  • UniProtKB: The soluble form derives from the membrane form by proteolytic processing
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43508

  • TNFSF12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNFSF12 Protein Expression
    REFSEQ proteins: NP_003800.1  
    ENSEMBL proteins: 
     ENSP00000293825   ENSP00000314636   ENSP00000451451  

    Human Recombinant Protein Products for TNFSF12: 
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    Sino Biological Recombinant Protein for TNFSF12
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    ProSpec Recombinant Protein for TNFSF12
    Cloud-Clone Corp. Proteins for TNFSF12 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS--
    GO:0005887integral to plasma membrane TAS9560343
    GO:0016020membrane ----
    GO:0048471perinuclear region of cytoplasm IDA14961121

    TNFSF12 for ontologies           About GeneDecksing



    TNFSF12 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for TNFSF12 

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    Cloud-Clone Corp. ELISAs for TNFSF12 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TNFSF: Tumor necrosis factor (ligand) superfamily

    2 InterPro protein domains:
     IPR006052 TNF
     IPR008983 Tumour_necrosis_fac-like_dom

    Graphical View of Domain Structure for InterPro Entry O43508

    ProtoNet protein and cluster: O43508

    1 Blocks protein domain: IPB006052 Tumor Necrosis Factor

    UniProtKB/Swiss-Prot: TNF12_HUMAN, O43508
    Similarity: Belongs to the tumor necrosis factor family


    TNFSF12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNF12_HUMAN, O43508
    Function: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates
    NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in
    induction of inflammatory cytokines

         Genatlas biochemistry entry for TNFSF12:
    tumor necrosis factor (ligand) superfamily,member 12,abundantly expressed in many tissues,inducing IL8,weakly
    inducer of apoptosis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS9560343
    GO:0005125cytokine activity TAS--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding IPI14961121
         
    TNFSF12 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tnfsf12):
     cellular  hematopoietic system  immune system  no phenotypic analysis 

    TNFSF12 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TNFSF12: Tnfsf12tm1.1Biib Tnfsf12tm1Ash

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNFSF12 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNFSF12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFSF12 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFSF12 

    miRNA
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    miRTarBase miRNAs that target TNFSF12:
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFSF12
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFSF12:
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF12


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNFSF12 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    IL-6 Pathway0.61
    MIF Regulation of Innate Immune Cells0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2TWEAK Pathway
    TWEAK Pathway0.87
    Apoptosis through Death Receptors0.42
    DR3 Signaling0.87
    TWEAK Signaling Pathway0.31
    3TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    4Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Apoptotic TNF-family pathways0.35
    Apoptosis Signaling Pathways0.35
    5Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for TNFSF12
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival Apoptotic TNF-family pathways

    2 R&D Systems Pathways for TNFSF12
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    Apoptosis Signaling Pathways

    5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFSF12 (see all 21)
        TWEAK Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    2 Cell Signaling Technology (CST) Pathways for TNFSF12
        Apoptosis and Autophagy
    NF-kappaB Signaling

    2 GeneGo (Thomson Reuters) Pathways for TNFSF12
        Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    1 BioSystems Pathway for TNFSF12
        TWEAK Signaling Pathway

    3 Sino Biological Pathways for TNFSF12 
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1         Kegg Pathway  (Kegg details for TNFSF12):
        Cytokine-cytokine receptor interaction


    TNFSF12 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFSF12

    3 Interacting proteins for TNFSF12 (O435083) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGGF1Q8N3023I2D: score=3 
    TNFRSF25Q930383I2D: score=2 
    TNFRSF12AQ9NP843I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001938positive regulation of endothelial cell proliferation TAS14961121
    GO:0006915apoptotic process IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS9560343

    TNFSF12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFSF12 (TNF12)

    Search CenterWatch for drugs/clinical trials and news about TNFSF12 / TNF12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNFSF12 gene: 
    NM_003809.2  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293825(uc002ghg.3) ENST00000322272(uc002ghh.3) ENST00000462619
    ENST00000462811 ENST00000557233
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    24/342 AceView cDNA sequences (see all 342):

    AA424562 AI432668 BM670282 BF196031 CD370028 AA357370 BM691427 NM_153012 
    BQ073114 H00454 AI492292 NM_003809 AF136294 AI298067 BU630692 BM712014 
    BM974244 AI581741 AW592336 BG272792 AI267879 BU579826 BI758093 AY377858 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFSF12 expression in normal human tissues (normalized intensities)      TNFSF12 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TNFSF12 Expression
    About this image


    TNFSF12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
     
     Lung (Respiratory System)

    See TNFSF12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFSF12

    UniProtKB/Swiss-Prot: TNF12_HUMAN, O43508
    Tissue specificity: Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine,
    lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney,
    testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFSF12: 
              TNF Ligands & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Apoptosis in human mouse rat
              Angiogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TNFSF12 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfsf121 , 5 tumor necrosis factor (ligand) superfamily, member more1, 5 88.35(n)1
    89.16(a)1
      11 (42.86 cM)5
    219441  NM_011614.31  NP_035744.11 
     696862505 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    34(a)
    1 → many
    GL343660.1(16198-37951)
    zebrafish
    (Danio rerio)
    Actinopterygii tnfsf121 tumor necrosis factor (ligand) superfamily, member more 46.87(n)
    34.06(a)
      567542  NM_001076607.1  NP_001070075.1 


    ENSEMBL Gene Tree for TNFSF12 (if available)
    TreeFam Gene Tree for TNFSF12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFSF12 gene
    TNFSF12-TNFSF132  TNFSF13B2  TNFSF132  
    1 SIMAP similar gene for TNFSF12 using alignment to 2 protein entries:     TNF12_HUMAN (see all proteins):
    TWEAK

    TNFSF12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TNFSF12:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    nsv457659CNV Loss19166990
    nsv907651CNV Loss21882294
    nsv523672CNV Loss19592680


    Human Gene Mutation Database (HGMD): TNFSF12
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602695    OMIM disorders: --

    20/39 diseases for TNFSF12 (see all 39):    About MalaCards
    chronic graft versus host disease    hemophagocytic lymphohistiocytosis    klippel-trenaunay syndrome    skeletal muscle regeneration
    psoriatic arthritis    abdominal aortic aneurysm    eczema    lupus nephritis
    keloids    graft versus host disease    aortic aneurysm    nephritis
    systemic lupus erythematosus    atherosclerosis    endotheliitis    acute pancreatitis
    pulmonary fibrosis    type 1 diabetes mellitus    multiple sclerosis    hypoxia


    TNFSF12 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for TNFSF12 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 37.7 4 16547002 (1), 18483204 (1), 12411489 (1), 12651623 (1)
    atherosclerotic plaque 34.9 6 16809572 (4), 15056843 (1)
    inflammation 27 4 19482507 (2), 17981571 (1), 16503147 (1)
    atherosclerosis 22.9 2 15056843 (1), 16809572 (1)
    tumors 15.4 4 16547002 (1), 18483204 (1), 12651623 (1), 17548657 (1)

    Genetic Association Database (GAD): TNFSF12
    Human Genome Epidemiology (HuGE) Navigator: TNFSF12 (4 documents)

    Export disorders for TNFSF12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFSF12 gene, integrated from 9 sources (see all 127):
    (articles sorted by number of sources associating them with TNFSF12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a ligand for the death-domain-containing receptor Apo3. (PubMed id 9560343)1, 2, 3 Marsters S.A....Ashkenazi A. (1998)
    2. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. (PubMed id 9405449)1, 2, 3 Chicheportiche Y.... Browning J.L. (1997)
    3. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    4. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PubMed id 18174230)1, 4 Miyagawa H....Horiuchi T. (2008)
    5. Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome. (PubMed id 14961121)1, 2 Tian X.-L.... Wang Q. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor. (PubMed id 12787562)1, 2 Wiley S.R. and Winkles J.A. (2003)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. TWEAK induces angiogenesis and proliferation of endothelial cells. (PubMed id 10085077)1, 2 Lynch C.N.... Wiley S.R. (1999)
    10. A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications. (PubMed id 17548657)1, 9 Bover L.C....Pasqualini R. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8742 HGNC: 11927 AceView: TNFSF13 Ensembl:ENSG00000239697 euGenes: HUgn8742
    ECgene: TNFSF12 Kegg: 8742 H-InvDB: TNFSF12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFSF12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFSF12 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNFSF12 gene:
    Search GeneIP for patents involving TNFSF12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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