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Aliases for TNFSF12 Gene

Aliases for TNFSF12 Gene

  • Tumor Necrosis Factor (Ligand) Superfamily, Member 12 2 3
  • APO3L 3 4 6
  • DR3LG 3 4 6
  • TWEAK 3 4 6
  • APO3 Ligand 3 4
  • Tumor Necrosis Factor Ligand Superfamily Member 12 3
  • TNF-Related WEAK Inducer Of Apoptosis 3
  • TNF-Related Weak Inducer Of Apoptosis 4
  • APO3/DR3 Ligand 3

External Ids for TNFSF12 Gene

Previous GeneCards Identifiers for TNFSF12 Gene

  • GC17P007866
  • GC17P008192
  • GC17P007395
  • GC17P007652
  • GC17P007394
  • GC17P007401
  • GC17P007452
  • GC17P007346

Summaries for TNFSF12 Gene

Entrez Gene Summary for TNFSF12 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

GeneCards Summary for TNFSF12 Gene

TNFSF12 (Tumor Necrosis Factor (Ligand) Superfamily, Member 12) is a Protein Coding gene. Diseases associated with TNFSF12 include peripheral artery disease and skeletal muscle regeneration. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF13.

UniProtKB/Swiss-Prot for TNFSF12 Gene

  • Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.

Gene Wiki entry for TNFSF12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF12 Gene

Genomics for TNFSF12 Gene

Regulatory Elements for TNFSF12 Gene

Genomic Location for TNFSF12 Gene

Start:
7,548,891 bp from pter
End:
7,557,890 bp from pter
Size:
9,000 bases
Orientation:
Plus strand

Genomic View for TNFSF12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFSF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF12 Gene

Proteins for TNFSF12 Gene

  • Protein details for TNFSF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43508-TNF12_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 12
    Protein Accession:
    O43508
    Secondary Accessions:
    • Q8IZK7
    • Q8WUZ7

    Protein attributes for TNFSF12 Gene

    Size:
    249 amino acids
    Molecular mass:
    27216 Da
    Quaternary structure:
    • Homotrimer (Probable). Interacts with the angiogenic factor AGGF1/VG5Q.
    SequenceCaution:
    • Sequence=AAH19047.1; Type=Frameshift; Positions=125; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNFSF12 Gene

    Alternative splice isoforms for TNFSF12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFSF12 Gene

Proteomics data for TNFSF12 Gene at MOPED

Post-translational modifications for TNFSF12 Gene

  • The soluble form derives from the membrane form by proteolytic processing
  • Glycosylation at Asn139
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFSF12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFSF12 Gene

Domains for TNFSF12 Gene

Gene Families for TNFSF12 Gene

HGNC:
  • TNFSF :Tumor necrosis factor (ligand) superfamily

Protein Domains for TNFSF12 Gene

Suggested Antigen Peptide Sequences for TNFSF12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43508

UniProtKB/Swiss-Prot:

TNF12_HUMAN :
  • O43508
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF12: view

Function for TNFSF12 Gene

Molecular function for TNFSF12 Gene

GENATLAS Biochemistry: tumor necrosis factor (ligand) superfamily,member 12,abundantly expressed in many tissues,inducing IL8,weakly inducer of apoptosis
UniProtKB/Swiss-Prot Function: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.

Gene Ontology (GO) - Molecular Function for TNFSF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 9560343
GO:0005125 cytokine activity TAS 21525013
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 14961121
genes like me logo Genes that share ontologies with TNFSF12: view

Phenotypes for TNFSF12 Gene

genes like me logo Genes that share phenotypes with TNFSF12: view

Animal Models for TNFSF12 Gene

MGI Knock Outs for TNFSF12:

miRNA for TNFSF12 Gene

miRTarBase miRNAs that target TNFSF12

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TNFSF12 Gene

Localization for TNFSF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF12 Gene

Cell membrane; Single-pass type II membrane protein.
Tumor necrosis factor ligand superfamily member 12, secreted form: Secreted.
Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFSF12 Gene COMPARTMENTS Subcellular localization image for TNFSF12 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 4
nucleus 4
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TNFSF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 21525013
GO:0005887 integral component of plasma membrane TAS 9560343
GO:0016020 membrane --
GO:0048471 perinuclear region of cytoplasm IDA 14961121
genes like me logo Genes that share ontologies with TNFSF12: view

Pathways for TNFSF12 Gene

genes like me logo Genes that share pathways with TNFSF12: view

Interacting Proteins for TNFSF12 Gene

Gene Ontology (GO) - Biological Process for TNFSF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001938 positive regulation of endothelial cell proliferation TAS 14961121
GO:0006915 apoptotic process IEA --
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 9560343
genes like me logo Genes that share ontologies with TNFSF12: view

Transcripts for TNFSF12 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF12 Gene

No ASD Table

Relevant External Links for TNFSF12 Gene

GeneLoc Exon Structure for
TNFSF12
ECgene alternative splicing isoforms for
TNFSF12

Expression for TNFSF12 Gene

mRNA expression in normal human tissues for TNFSF12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA Expression by UniProt/SwissProt for TNFSF12 Gene

O43508-TNF12_HUMAN
Tissue specificity: Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain
genes like me logo Genes that share expressions with TNFSF12: view

No data available for mRNA differential expression in normal tissues and Protein expression for TNFSF12 Gene

Orthologs for TNFSF12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFSF12 35
  • 100 (n)
  • 100 (a)
TNFSF12 36
  • 69 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia TNFSF12 35
  • 88.94 (n)
  • 85.11 (a)
TNFSF13B 36
  • 10 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia TNFSF12 35
  • 88.46 (n)
  • 88.94 (a)
TNFSF12 36
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia BC096441 36
  • 68 (a)
ManyToMany
Tnfsf12 35
  • 88.35 (n)
  • 89.16 (a)
Tnfsf12 16
Tnfsf12 36
  • 68 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia TNFSF13 36
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 23 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tnfsf12 35
  • 88.22 (n)
  • 87.55 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tnfsf12 35
  • 49.34 (n)
  • 40.13 (a)
tnfsf13 36
  • 33 (a)
OneToMany
Species with no ortholog for TNFSF12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFSF12 Gene

ENSEMBL:
Gene Tree for TNFSF12 (if available)
TreeFam:
Gene Tree for TNFSF12 (if available)

Paralogs for TNFSF12 Gene

Paralogs for TNFSF12 Gene

Selected SIMAP similar genes for TNFSF12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TNFSF12: view

Variants for TNFSF12 Gene

Structural Variations from Database of Genomic Variants (DGV) for TNFSF12 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv523672 CNV Loss 19592680
nsv907651 CNV Loss 21882294

Relevant External Links for TNFSF12 Gene

HapMap Linkage Disequilibrium report
TNFSF12
Human Gene Mutation Database (HGMD)
TNFSF12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TNFSF12 Gene

Disorders for TNFSF12 Gene

(5) Novoseek inferred disease relationships for TNFSF12 Gene

Disease -log(P) Hits PubMed IDs
necrosis 37.7 4
atherosclerotic plaque 34.9 5
inflammation 27 4
atherosclerosis 22.9 2
tumors 15.4 4

Relevant External Links for TNFSF12

Genetic Association Database (GAD)
TNFSF12
Human Genome Epidemiology (HuGE) Navigator
TNFSF12
genes like me logo Genes that share disorders with TNFSF12: view

No data available for UniProtKB/Swiss-Prot for TNFSF12 Gene

Publications for TNFSF12 Gene

  1. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. (PMID: 9405449) Chicheportiche Y. … Browning J.L. (J. Biol. Chem. 1997) 2 3 4
  2. Identification of a ligand for the death-domain-containing receptor Apo3. (PMID: 9560343) Marsters S.A. … Ashkenazi A. (Curr. Biol. 1998) 2 3 4
  3. TWEAK induces angiogenesis and proliferation of endothelial cells. (PMID: 10085077) Lynch C.N. … Wiley S.R. (J. Biol. Chem. 1999) 3 4
  4. An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein. (PMID: 12411489) Pradet-Balade B. … Hahne M. (EMBO J. 2002) 4 23
  5. TWEAK can induce pro-inflammatory cytokines and matrix metalloproteinase-9 in macrophages. (PMID: 15056843) Kim S.H. … Lee W.H. (Circ. J. 2004) 3 23

Products for TNFSF12 Gene

Sources for TNFSF12 Gene

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