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Aliases for TNFSF12 Gene

Aliases for TNFSF12 Gene

  • Tumor Necrosis Factor Superfamily Member 12 2 3 5
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 12 2 3
  • APO3 Ligand 3 4
  • APO3L 3 4
  • DR3LG 3 4
  • TWEAK 3 4
  • Tumor Necrosis Factor Ligand Superfamily Member 12 3
  • TNF-Related WEAK Inducer Of Apoptosis 3
  • TNF-Related Weak Inducer Of Apoptosis 4
  • Tumor Necrosis Factor Ligand 4A 3
  • APO3/DR3 Ligand 3
  • TNLG4A 3

External Ids for TNFSF12 Gene

Previous GeneCards Identifiers for TNFSF12 Gene

  • GC17P007866
  • GC17P008192
  • GC17P007395
  • GC17P007652
  • GC17P007394
  • GC17P007401
  • GC17P007452
  • GC17P007346
  • GC17P007550
  • GC17P007553

Summaries for TNFSF12 Gene

Entrez Gene Summary for TNFSF12 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

GeneCards Summary for TNFSF12 Gene

TNFSF12 (Tumor Necrosis Factor Superfamily Member 12) is a Protein Coding gene. Diseases associated with TNFSF12 include Common Variable Immunodeficiency. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Immune System. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF12-TNFSF13.

UniProtKB/Swiss-Prot for TNFSF12 Gene

  • Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.

Gene Wiki entry for TNFSF12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF12 Gene

Genomics for TNFSF12 Gene

Regulatory Elements for TNFSF12 Gene

Enhancers for TNFSF12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F007548 1.4 FANTOM5 ENCODE 22.7 +2.2 2221 5.8 HDGF ATF1 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF48 YY1 ZNF121 TNFSF12 SAT2 CHRNB1 RPL26 ENSG00000226871 ARHGEF15 SNORA48 MIR324 ATP1B2 TMEM102
GH17F007474 1.6 FANTOM5 ENCODE 12.7 -68.3 -68302 12.5 CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DVL2 SNORD10 SNORA48 CHRNB1 PFAS LOC105371523 KCTD11 CTC1 CNTROB MIR6883
GH17F007613 1 ENCODE 18.7 +65.7 65671 2.9 HDGF ATF1 PKNOX1 ARID4B SIN3A YY1 GTF3C2 GLIS2 ZNF143 ZNF548 DVL2 SNORD10 PFAS SNORA48 CTC1 CNTROB LOC105371523 TNFSF12 MIR6883 SOX15
GH17F007556 1.1 ENCODE 11.6 +10.9 10900 7.1 HDGF MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 DEK SAT2 CHRNB1 TNFSF12 TNFSF13 SNORA48 GC17P007611
GH17F007401 1.1 ENCODE 10.4 -144.8 -144766 4.8 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 DVL2 ENSG00000262067 ENSG00000271029 SPEM1 ENSG00000262089 SNORD10 C17orf74 CNTROB CHRNB1 ACAP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFSF12 on UCSC Golden Path with GeneCards custom track

Promoters for TNFSF12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001340234 309 1601 HDGF PKNOX1 KLF17 ARID4B ZNF48 ZNF366 KLF7 EGR2 SP5 ZEB2

Genomic Location for TNFSF12 Gene

Chromosome:
17
Start:
7,548,891 bp from pter
End:
7,557,890 bp from pter
Size:
9,000 bases
Orientation:
Plus strand

Genomic View for TNFSF12 Gene

Genes around TNFSF12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF12 Gene

Proteins for TNFSF12 Gene

  • Protein details for TNFSF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43508-TNF12_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 12
    Protein Accession:
    O43508
    Secondary Accessions:
    • Q8IZK7
    • Q8WUZ7

    Protein attributes for TNFSF12 Gene

    Size:
    249 amino acids
    Molecular mass:
    27216 Da
    Quaternary structure:
    • Homotrimer (Probable). Interacts with the angiogenic factor AGGF1/VG5Q.
    SequenceCaution:
    • Sequence=AAH19047.1; Type=Frameshift; Positions=125; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNFSF12 Gene

    Alternative splice isoforms for TNFSF12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFSF12 Gene

Post-translational modifications for TNFSF12 Gene

  • The soluble form derives from the membrane form by proteolytic processing.
  • Glycosylation at Asn 139
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFSF12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFSF12 (TWEAK/TNFSF12)
  • Cell Signaling Technology (CST) Antibodies for TNFSF12 (TNFSF12)
  • Santa Cruz Biotechnology (SCBT) Antibodies for TNFSF12

Protein Products

  • Enzo Life Sciences proteins for TNFSF12

No data available for DME Specific Peptides for TNFSF12 Gene

Domains & Families for TNFSF12 Gene

Gene Families for TNFSF12 Gene

Protein Domains for TNFSF12 Gene

Suggested Antigen Peptide Sequences for TNFSF12 Gene

Graphical View of Domain Structure for InterPro Entry

O43508

UniProtKB/Swiss-Prot:

TNF12_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF12: view

Function for TNFSF12 Gene

Molecular function for TNFSF12 Gene

GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 12,abundantly expressed in many tissues,inducing IL8,weakly inducer of apoptosis
UniProtKB/Swiss-Prot Function:
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.

Gene Ontology (GO) - Molecular Function for TNFSF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 9560343
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 14961121
genes like me logo Genes that share ontologies with TNFSF12: view
genes like me logo Genes that share phenotypes with TNFSF12: view

Human Phenotype Ontology for TNFSF12 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TNFSF12 Gene

MGI Knock Outs for TNFSF12:

Animal Model Products

  • Taconic Biosciences Mouse Models for TNFSF12

miRNA for TNFSF12 Gene

miRTarBase miRNAs that target TNFSF12

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNFSF12 Gene

Localization for TNFSF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF12 Gene

Cell membrane; Single-pass type II membrane protein.
Tumor necrosis factor ligand superfamily member 12, secreted form: Secreted.
Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF12 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 2
cytosol 2
nucleus 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TNFSF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 9560343
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFSF12: view

Pathways & Interactions for TNFSF12 Gene

genes like me logo Genes that share pathways with TNFSF12: view

Interacting Proteins for TNFSF12 Gene

Gene Ontology (GO) - Biological Process for TNFSF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001938 positive regulation of endothelial cell proliferation TAS 14961121
GO:0006915 apoptotic process IEA,TAS 9560343
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 9560343
genes like me logo Genes that share ontologies with TNFSF12: view

No data available for SIGNOR curated interactions for TNFSF12 Gene

Transcripts for TNFSF12 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF12 Gene

No ASD Table

Relevant External Links for TNFSF12 Gene

GeneLoc Exon Structure for
TNFSF12
ECgene alternative splicing isoforms for
TNFSF12

Expression for TNFSF12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFSF12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TNFSF12 Gene:

TNFSF12

mRNA Expression by UniProt/SwissProt for TNFSF12 Gene:

O43508-TNF12_HUMAN
Tissue specificity: Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
genes like me logo Genes that share expression patterns with TNFSF12: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TNFSF12 Gene

Orthologs for TNFSF12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFSF12 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia TNFSF12 34
  • 88.94 (n)
TNFSF13B 35
  • 10 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia TNFSF12 34 35
  • 88.46 (n)
mouse
(Mus musculus)
Mammalia Tnfsf12 34 16 35
  • 88.35 (n)
BC096441 35
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tnfsf12 34
  • 88.22 (n)
oppossum
(Monodelphis domestica)
Mammalia TNFSF13 35
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 33 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tnfsf12 34
  • 49.34 (n)
tnfsf13 35
  • 33 (a)
OneToMany
Species where no ortholog for TNFSF12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFSF12 Gene

ENSEMBL:
Gene Tree for TNFSF12 (if available)
TreeFam:
Gene Tree for TNFSF12 (if available)

Paralogs for TNFSF12 Gene

Paralogs for TNFSF12 Gene

(1) SIMAP similar genes for TNFSF12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TNFSF12: view

Variants for TNFSF12 Gene

Sequence variations from dbSNP and Humsavar for TNFSF12 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs540997935 Uncertain significance 7,556,837(+) CTCTG(C/T)GCTAC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs11078696 -- 7,555,982(+) TTTTT(G/T)TTTTT intron-variant
rs111505625 -- 7,548,141(+) GGTCC(G/T)TCCTT upstream-variant-2KB
rs111806611 -- 7,552,435(+) CGATT(C/G)TCCTG intron-variant
rs111860500 -- 7,558,015(+) GACCT(C/G)CATGC intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TNFSF12 Gene

Variant ID Type Subtype PubMed ID
nsv574322 CNV loss 21841781
nsv523672 CNV loss 19592680
nsv457659 CNV loss 19166990
esv2422288 CNV deletion 17116639

Variation tolerance for TNFSF12 Gene

Residual Variation Intolerance Score: 26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFSF12 Gene

Human Gene Mutation Database (HGMD)
TNFSF12
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFSF12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF12 Gene

Disorders for TNFSF12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TNFSF12 Gene - From: Orphanet

Disorder Aliases PubMed IDs
common variable immunodeficiency
  • acquired agammaglobulinemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFSF12

Genetic Association Database (GAD)
TNFSF12
Human Genome Epidemiology (HuGE) Navigator
TNFSF12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFSF12
genes like me logo Genes that share disorders with TNFSF12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF12 Gene

Publications for TNFSF12 Gene

  1. Identification of a ligand for the death-domain-containing receptor Apo3. (PMID: 9560343) Marsters S.A. … Ashkenazi A. (Curr. Biol. 1998) 2 3 4 64
  2. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. (PMID: 9405449) Chicheportiche Y. … Browning J.L. (J. Biol. Chem. 1997) 2 3 4 64
  3. Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway. (PMID: 20385556) Brown S.A. … Winkles J.A. (J. Biol. Chem. 2010) 3 22 64
  4. Considering TWEAK as a target for therapy in renal and vascular injury. (PMID: 19482507) Ortiz A. … Blanco-Colio L.M. (Cytokine Growth Factor Rev. 2009) 3 22 64
  5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64

Products for TNFSF12 Gene

Sources for TNFSF12 Gene

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