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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFSF12 Gene

protein-coding   GIFtS: 53
GCID: GC17P007452

tumor necrosis factor (ligand) superfamily, member 12
 Explore 36 diseases affiliated with
TNFSF12 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TNFSF12    

Aliases
for TNFSF12 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Necrosis Factor (Ligand) Superfamily, Member 121 2     TNF-Related Weak Inducer Of Apoptosis2 3
APO3L1 2 3 5     APO3 Ligand2 3
DR3LG1 2 3 5     APO3/DR3 Ligand2
TWEAK1 2 3 5     Tumor Necrosis Factor Ligand Superfamily Member 122

External Ids:    HGNC: 119271   Entrez Gene: 87422   Ensembl: ENSG000002396977   OMIM: 6026955   UniProtKB: O435083   

Export aliases for TNFSF12 gene to outside databases

Previous GC identifers: GC17P007866 GC17P008192 GC17P007395 GC17P007652 GC17P007394 GC17P007401 GC17P007346


Summaries
for TNFSF12 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TNFSF12:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This
protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but
displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can
induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to
promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative
splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into
the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977,
TNFSF12-TNFSF13. (provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: TNF12_HUMAN, O43508
Function: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates
NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of
inflammatory cytokines

Gene Wiki entry for TNFSF12


Genomic Views
for TNFSF12 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFSF12 gene promoter:
         AP-1   ATF-2   FOXO1a   MyoD   c-Jun   NF-kappaB   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TNFSF12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFSF12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

TNFSF12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFSF12 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007452:  view genomic region     (about GC identifiers)

Start:
 7,452,208 bp from pter      End:
 7,464,925 bp from pter
Size:
 12,718 bases      Orientation:
 plus strand

Proteins
for TNFSF12 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TNF12_HUMAN, O43508 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 12  
Size: 249 amino acids; 27216 Da
Subunit: Homotrimer (Potential). Interacts with the angiogenic factor AGGF1/VG5Q
Subcellular location: Cell membrane; Single-pass type II membrane protein
Subcellular location: Tumor necrosis factor ligand superfamily member 12, secreted form: Secreted
Subcellular location: Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein
Sequence caution: Sequence=AAH19047.1; Type=Frameshift; Positions=125;
Secondary accessions: Q8IZK7 Q8WUZ7
Alternative splicing: 2 isoforms:  O43508-1   O43508-2   (Endogenous hybrid transcript between TWEAK and APRIL. Expressed at protein level in primary T-lymphocytes and monocytic cell lines)

Explore the universe of human proteins at neXtProt for TNFSF12: NX_O43508

Post-translational modifications:

  • The soluble form derives from the membrane form by proteolytic processing1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43508

    • TNFSF12 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003800.1  
    ENSEMBL proteins: 
     ENSP00000293825   ENSP00000314636   ENSP00000451451  

    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant TNFSF12 Protein
    R&D Systems Recombinant & Natural Proteins for TNFSF12 (TWEAK/TNFSF12)
    Enzo Life Sciences proteins for TNFSF12
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: TNFSF12
    OriGene Custom Protein Services for TNFSF12 
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    Novus Biologicals TNFSF12 Proteins
    Novus Biologicals TNFSF12 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for TNFSF12
    Uscn Proteins for TNFSF12

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS--
    GO:0005887integral to plasma membrane TAS9560343
    GO:0016020membrane ----
    GO:0048471perinuclear region of cytoplasm IDA14961121


    TNFSF12 for ontologies           About GeneDecksing



    TNFSF12 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TNFSF12
    R&D Systems Antibodies for TNFSF12 (TWEAK/TNFSF12)
    Cell Signaling Technology (CST) Antibodies for TNFSF12 
    OriGene Antibodies: TNFSF12
    OriGene Custom Antibody Services for TNFSF12 
    GenScript Custom Superior Antibodies Services for TNFSF12
    Novus Biologicals TNFSF12 Antibodies
    Search for Antibodies for TNFSF12 at Abcam  
    Uscn Antibodies for TNFSF12
    ThermoFisher Antibodies for TNFSF12

    Assay Products for TNFSF12: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for TNFSF12 (TWEAK/TNFSF12)         (see all)
    GenScript Custom Assay Services for TNFSF12
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TNFSF12

    Protein Domains /
    Families
    for TNFSF12 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TNFSF12 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR006052 TNF
     IPR008983 Tumour_necrosis_fac-like_dom

    Graphical View of Domain Structure for InterPro Entry O43508

    ProtoNet protein and cluster: O43508

    1 Blocks protein family: IPB006052 Tumor Necrosis Factor

    UniProtKB/Swiss-Prot: TNF12_HUMAN, O43508
    Similarity: Belongs to the tumor necrosis factor family


    Function
    for TNFSF12 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TNF12_HUMAN, O43508
    Function: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates
    NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of
    inflammatory cytokines

         Genatlas biochemistry entry for TNFSF12:
    tumor necrosis factor (ligand) superfamily,member 12,abundantly expressed in many tissues,inducing IL8,weakly inducer
    of apoptosis

    miRNA
    Products:            		miRTarBase miRNAs that target TNFSF12:
    hsa-mir-17 (MIRT004681)

    OriGene 3'-UTR Clone: TNFSF12
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFSF12
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFSF12:
    hsa-miR-889 hsa-miR-3176 hsa-miR-548c-3p hsa-miR-3922-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFSF12 (see all 10)
    OriGene shRNA RFP: TNFSF12
    OriGene siRNA: TNFSF12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFSF12

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TNFSF12

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF12 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF12
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TNFSF12 (NM_003809)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFSF12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF12 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TNFSF12
    Search LifeMap BioReagents cell lines for TNFSF12

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF12

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS9560343
    GO:0005125cytokine activity TAS--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding IPI14961121


    TNFSF12 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for TNFSF12: Tnfsf12tm1.1Biib Tnfsf12tm1Ash
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tnfsf12):
     cellular  hematopoietic system  immune system  no phenotypic analysis 

    TNFSF12 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TNFSF12 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/9 pathways (see all 9)
    		PEDF Induced Signaling1.00
    		RAR-Gamma-RXR-Alpha Degradation0.54
    		MIF Mediated Glucocorticoid Regulation0.73
    		STAT3 Pathway0.47
    		MIF Regulation of Innate Immune Cells0.71
    		Endothelin-1 Signaling Pathway0.44
    		IL-6 Pathway0.61
    		Cytokine-cytokine receptor interaction0.26
    2TWEAK Pathway
    		TWEAK Pathway1.00
    		Apoptosis through Death Receptors0.32
    		DR3 Signaling0.87
    		TWEAK Signaling Pathway0.31
    3Apoptosis and survival_Apoptotic TNF-family pathways
    		Apoptosis and survival Apoptotic TNF-family pathways1.00
    		Apoptosis Signaling Pathways0.35
    		Apoptosis and survival_Apoptotic TNF-family pathways1.00
    4Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    5Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for TNFSF12
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival Apoptotic TNF-family pathways

    2 R&D Systems Pathways for TNFSF12
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    Apoptosis Signaling Pathways

    5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFSF12 (see all 21)
        TWEAK Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    2 Cell Signaling Technology (CST) Pathways for TNFSF12
        Apoptosis and Autophagy
    NF-kappaB Signaling

    2 GeneGo (Thomson Reuters) Pathways for TNFSF12
        Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    1 BioSystems Pathway for TNFSF12 
        TWEAK Signaling Pathway


    1         Kegg Pathway  (Kegg details for TNFSF12):
        Cytokine-cytokine receptor interaction


    TNFSF12 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFSF12

    3 Interacting proteins for TNFSF12 (O435083) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGGF1Q8N3023I2D: score=3 
    TNFRSF25Q930383I2D: score=2 
    TNFRSF12AQ9NP843I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001938positive regulation of endothelial cell proliferation TAS14961121
    GO:0006915apoptotic process IEA--
    GO:0006917induction of apoptosis TAS9560343
    GO:0006955immune response IEA--


    TNFSF12 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TNFSF12 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFSF12
    Search CenterWatch for drugs/clinical trials and news about TNFSF12 / TNF12 

    Transcripts
    for TNFSF12 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TNFSF12 gene: 
    NM_003809.2  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293825(uc002ghg.3) ENST00000322272(uc002ghh.3) ENST00000462619
    ENST00000462811 ENST00000557233

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TNFSF12
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFSF12
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFSF12:
    hsa-miR-889 hsa-miR-3176 hsa-miR-548c-3p hsa-miR-3922-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFSF12 (see all 10)
    OriGene shRNA RFP: TNFSF12
    OriGene siRNA: TNFSF12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFSF12
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF12 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF12
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TNFSF12 (NM_003809)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFSF12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF12 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFSF12
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFSF12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFSF12

    24/342 AceView cDNA sequences (see all 342):

    AY377858 BF111820 NM_003808 BM997880 AW129324 BI758093 BF476443 AI498385 
    AA357370 BQ016244 BQ073114 AI310092 CF126932 BM662622 AK090698 BC019047 
    AA424562 CA941046 BC008042 AW204512 BF196031 BM691427 AI378132 CD366782 

    GeneLoc Exon Structure


    Expression
    for TNFSF12 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFSF12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TNFSF12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFSF12

    UniProtKB/Swiss-Prot: TNF12_HUMAN, O43508
    Tissue specificity: Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung,
    ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis,
    liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFSF12: 
              TNF Ligands & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Apoptosis in human mouse rat
              Angiogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFSF12
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF12

    Orthologs
    for TNFSF12 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TNFSF12 gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii tnfsf121 tumor necrosis factor (ligand) superfamily, member more 46.87(n)
    34.06(a)    		   567542  NM_001076607.1  NP_001070075.1 


    ENSEMBL Gene Tree for TNFSF12 (if available)
    TreeFam Gene Tree for TNFSF12 (if available) 

    Paralogs
    for TNFSF12 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNFSF12 gene
    TNFSF12-TNFSF132  TNFSF13B2  TNFSF132  
    1 SIMAP similar gene for TNFSF12 using alignment to 2 protein entries:     TNF12_HUMAN (see all proteins):
    TWEAK

    TNFSF12 for paralogs           About GeneDecksing



    Genomic Variants
    for TNFSF12 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/164 NCBI SNPs in TNFSF12 are shown (see all 164)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1437316911,2
    		--7450552(+) TCATGA/CGATCT 3 -- us2k10--------
    rs129450841,2
    		C,--7450637(+) gtgccC/Tgccac 3 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1819915351,2
    		--7450753(+) AAGTGC/TTGGGA 3 -- us2k10--------
    rs129459771,2
    		C,F,--7450911(+) ttgctC/Ggtgtt 3 -- us2k14Minor allele frequency- G:0.17NA WA 242
    rs1863239481,2
    		--7450930(+) GTGGTA/GTGATC 3 -- us2k10--------
    rs1906754431,2
    		--7450972(+) CAGGTG/TATCCT 3 -- us2k10--------
    rs1156413881,2
    		C,F,--7451075(+) TAGGTA/GGTACT 3 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1178084471,2
    		F,--7451081(+) GTACTC/TTTTGT 3 -- us2k11Minor allele frequency- T:0.02NA 120
    rs347909081,2
    		C,F,H,--7451110(+) TTCCTC/TCAATG 3 -- us2k116Minor allele frequency- T:0.15NS EA NA WA 2202
    rs2000214251,2
    		--7451140(+) TTTGG-/TCTT  
                TCTTT     		3 -- us2k10--------

    HapMap Linkage Disequilibrium report for TNFSF12 (7452208 - 7464925 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TNFSF12: --

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    Disorders / Diseases
    for TNFSF12 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TNFSF12 for disorders           About GeneDecksing

    OMIM gene information: 602695    OMIM disorders: --

    20/36 diseases for TNFSF12 (see all 36):    About MalaCards
    klippel-trenaunay syndrome    skeletal muscle regeneration    graft versus host disease    abdominal aortic aneurysm
    hemophagocytic lymphohistiocytosis    aortic aneurysm    systemic lupus erythematosus    lupus erythematosus
    psoriatic arthritis    lupus nephritis    myocardial infarction    nephritis
    renal cell carcinoma    pulmonary fibrosis    eczema    rheumatoid arthritis
    multiple sclerosis    keloids    arthritis    atherosclerosis

    5 Novoseek disease relationships for TNFSF12 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 37.7 4 16547002 (1), 18483204 (1), 12411489 (1), 12651623 (1)
    atherosclerotic plaque 34.9 6 16809572 (4), 15056843 (1)
    inflammation 27 4 19482507 (2), 17981571 (1), 16503147 (1)
    atherosclerosis 22.9 2 15056843 (1), 16809572 (1)
    tumors 15.4 4 16547002 (1), 18483204 (1), 12651623 (1), 17548657 (1)

    Human Genome Epidemiology (HuGE) Navigator: TNFSF12 (4 documents)

    Export disorders for TNFSF12 gene to outside databases

    Publications
    for TNFSF12 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFSF12 gene, integrated from 9 sources (see all 115):
    (articles sorted by number of sources associating them with TNFSF12)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a ligand for the death-domain-containing receptor Apo3. (PubMed id 9560343)1, 2, 3 Marsters S.A....Ashkenazi A. (1998)
    2. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. (PubMed id 9405449)1, 2, 3 Chicheportiche Y.... Browning J.L. (1997)
    3. Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome. (PubMed id 14961121)1, 2 Tian X.-L.... Wang Q. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor. (PubMed id 12787562)1, 2 Wiley S.R. and Winkles J.A. (2003)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. TWEAK induces angiogenesis and proliferation of endothelial cells. (PubMed id 10085077)1, 2 Lynch C.N.... Wiley S.R. (1999)
    8. A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications. (PubMed id 17548657)1, 9 Bover L.C....Pasqualini R. (2007)
    9. Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway. (PubMed id 20385556)1, 9 Brown S.A....Winkles J.A. (2010)
    10. Considering TWEAK as a target for therapy in renal an d vascular injury. (PubMed id 19482507)1, 9 Ortiz A....Blanco-Colio L.M. (2009)

    External Searches for TNFSF12 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing TNFSF12 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8742 HGNC: 11927 AceView: TNFSF13 Ensembl:ENSG00000239697 euGenes: HUgn8742
    ECgene: TNFSF12 Kegg: 8742 H-InvDB: TNFSF12

    Other Databases showing TNFSF12 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TNFSF12 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFSF12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFSF12 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TNFSF12 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TNFSF12 gene:
    Search GeneIP for patents involving TNFSF12

    GeneCards and IP:
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