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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TNFSF10 Gene

protein-coding GIFtS: 70
GCID: GC03M172223

tumor necrosis factor (ligand) superfamily, member 10

Explore 165 diseases affiliated with
TNFSF10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tumor Necrosis Factor (Ligand) Superfamily, Member 10¹ ²		TNF-Related Apoptosis Inducing Ligand TRAIL²
TRAIL¹ ² ³ ⁵		Tumor Necrosis Factor (Ligand) Family, Member 10²
Apo-2L¹ ² ³		Tumor Necrosis Factor Apoptosis-Inducing Ligand Splice Variant Delta²
APO2L² ³ ⁵		Tumor Necrosis Factor Ligand Superfamily Member 10²
CD253¹ ²		CD253 Antigen³
TL2¹ ²		Protein TRAIL³
Apo-2 Ligand² ³		TNF-Related Apoptosis-Inducing Ligand³
Chemokine Tumor Necrosis Factor Ligand Superfamily Member 10²

External Ids:	HGNC: 11925¹	Entrez Gene: 8743²	Ensembl: ENSG00000121858⁷	OMIM: 603598⁵	UniProtKB: P50591³

ORGUL members:
	NONCODE:n409611

Export aliases for TNFSF10 gene to outside databases

Previous GC identifers: GC03M169274 GC03M173180 GC03M173625 GC03M173544 GC03M173706 GC03M169593

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFSF10:

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This

protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells

although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF

receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and

possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors

TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to

its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced

transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: TNF10_HUMAN, P50591

Function: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and

possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors

TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis

Gene Wiki entry for TNFSF10 (TRAIL)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNFSF10 gene promoter:
GR STAT1 Sp1 HSF1 (long) STAT5A PPAR-gamma1 HSF1short IRF-7A PPAR-gamma2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNFSF10 promoter sequence

Search SABiosciences Chromatin IP Primers for TNFSF10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFSF10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26 Ensembl cytogenetic band: 3q26.31 HGNC cytogenetic band: 3q26

TNFSF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFSF10 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M172223: view genomic region (about GC identifiers)

Start:	172,223,298 bp from pter	End:	172,241,297 bp from pter
Size:	18,000 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TNF10_HUMAN, P50591 (See protein sequence)

Recommended Name: Tumor necrosis factor ligand superfamily member 10

Size: 281 amino acids; 32509 Da

Cofactor: Binds 1 zinc ion per trimer

Subunit: Homotrimer

Subcellular location: Membrane; Single-pass type II membrane protein (Potential)

5 PDB 3D structures from and Proteopedia for TNFSF10:

1D0G (3D)

1D2Q (3D)

1D4V (3D)

1DG6 (3D)

1DU3 (3D)

Secondary accessions: A1Y9B3

Alternative splicing: 2 isoforms: P50591-1 P50591-2 (Induced upon HIV infection, antagonizes signaling via TRAIL receptor R2 (TNFRSF10B))

Explore the universe of human proteins at neXtProt for TNFSF10: NX_P50591

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P50591

TNFSF10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001177871.1 NP_001177872.1 NP_003801.1

ENSEMBL proteins:

ENSP00000241261 ENSP00000389931 ENSP00000404008

Reactome Protein details: P50591
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant TNFSF10 Protein
	R&D Systems Recombinant & Natural Proteins for TNFSF10 (TRAIL/TNFSF10)
	Enzo Life Sciences proteins for TNFSF10
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	GenScript Custom Purified and Recombinant Proteins Services for TNFSF10
	Novus Biologicals TNFSF10 Proteins Novus Biologicals TNFSF10 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for TNFSF10
	Uscn Proteins for TNFSF10

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005625	soluble fraction	--	--
GO:0005887	integral to plasma membrane	TAS	8663110

TNFSF10 for ontologies About GeneDecksing

TNFSF10 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TNFSF10
	R&D Systems Antibodies for TNFSF10 (TRAIL/TNFSF10)
	Cell Signaling Technology (CST) Antibodies for TNFSF10 (TRAIL)
	OriGene Antibodies: TNFSF10 OriGene Custom Antibody Services for TNFSF10
	GenScript Custom Superior Antibodies Services for TNFSF10
	Novus Biologicals TNFSF10 Antibodies
	Search for Antibodies for TNFSF10 at Abcam
	Uscn Antibodies for TNFSF10
	ThermoFisher Antibody for TNFSF10

Assay Products for TNFSF10:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for TNFSF10 (TRAIL/TNFSF10)
	GenScript Custom Assay Services for TNFSF10
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TNFSF10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNFSF10 for domains About GeneDecksing

4 InterPro domains/families:

IPR006052 TNF

IPR008983 Tumour_necrosis_fac-like_dom

IPR021184 TNF_CS

IPR017355 TNF_ligand_10/11

Graphical View of Domain Structure for InterPro Entry P50591

ProtoNet protein and cluster: P50591

1 Blocks protein family: IPB006052 Tumor Necrosis Factor

UniProtKB/Swiss-Prot: TNF10_HUMAN, P50591

Similarity: Belongs to the tumor necrosis factor family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TNF10_HUMAN, P50591

Function: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and

possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors

TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis

Genatlas biochemistry entry for TNFSF10:

tumor necrosis factor (ligand) superfamily,member 10,TNF-related apoptosis inducing ligand (TRAIL),predominantly

expressed in spleen,lung,prostate

miRNA Products:		OriGene 3'-UTR Clone: TNFSF10 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFSF10
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFSF10:
		hsa-miR-501-5p hsa-miR-876-5p hsa-miR-491-3p hsa-miR-3182 hsa-miR-3647-3p hsa-miR-3167
		SwitchGear 3'UTR luciferase reporter plasmid: TNFSF10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFSF10 (see all 7) OriGene shRNA RFP: TNFSF10 OriGene siRNA: TNFSF10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFSF10

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TNFSF10

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF10 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF10 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): TNFSF10 (NM_003810)
		Sino Biological Human cDNA Clone for TNFSF10
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFSF10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TNFSF10
		LifeMap BioReagents: cell line associated with TNFSF10: PureStem ES-209, Meso-prx/latp Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFSF10

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	8777713
GO:0005125	cytokine activity	IEA	--
GO:0005164	tumor necrosis factor receptor binding	IEA	--
GO:0005515	protein binding	IPI	--
GO:0046872	metal ion binding	IEA	--

TNFSF10 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TNFSF10:

Increased cell death in breast

Animal Models:
Mouse knock-outs for TNFSF10: Tnfsf10^tm1Sdg Tnfsf10^tm1Mjs
8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tnfsf10):

cellular	hematopoietic system	homeostasis/metabolism	immune system	liver/biliary system
mortality/aging	skeleton	tumorigenesis

TNFSF10 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Death Receptor Signalling

	Death Receptor Signalling	1.00			Dimerization of procaspase-8	0.75
	Extrinsic Pathway for Apoptosis	1.00			Caspase-8 activation	0.75

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TNFSF10

Apoptosis and survival Apoptotic TNF-family pathways

2 R&D Systems Pathways for TNFSF10

	TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
	Apoptosis Signaling Pathways

5/31 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFSF10 (see all 31)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	JNK Pathway

1 Cell Signaling Technology (CST) Pathway for TNFSF10

Apoptosis and Autophagy

1 GeneGo (Thomson Reuters) Pathway for TNFSF10

Apoptosis and survival Apoptotic TNF-family pathways

4 BioSystems Pathways for TNFSF10

	Apoptosis
	Apoptosis Modulation and Signaling
	TP53 network
	TRAIL signaling pathway

5/6 Reactome Pathways for TNFSF10 (see all 6)

	Death Receptor Signalling
	Extrinsic Pathway for Apoptosis
	Caspase-8 activation
	TRAIL signaling
	Dimerization of procaspase-8

5 Kegg Pathways (Kegg details for TNFSF10):

	Cytokine-cytokine receptor interaction
	Apoptosis
	Natural killer cell mediated cytotoxicity
	Measles
	Influenza A

TNFSF10 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TNFSF10

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

5/31 Interacting proteins for TNFSF10 (P50591^{1, 2, 3} ENSP00000241261⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CUL3	Q13618¹^,³, ENSP00000264414⁴	EBI-495373,EBI-456129 I2D: score=1 STRING: ENSP00000264414
ACP5	P13686²^,³	MINT-63835 I2D: score=5
TNFRSF10B	O14763¹^,²^,³, ENSP00000276431⁴	EBI-495373,EBI-518882 MINT-24897 I2D: score=7 STRING: ENSP00000276431
TNFRSF10A	O00220¹^,³, ENSP00000221132⁴	EBI-495373,EBI-518861 I2D: score=4 STRING: ENSP00000221132
CASP8	Q14790³, ENSP00000351273⁴	I2D: score=3 STRING: ENSP00000351273

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	TAS	--
GO:0006917	induction of apoptosis	TAS	8663110
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	TAS	--
GO:0006955	immune response	IEA	--
GO:0007165	signal transduction	TAS	8777713

TNFSF10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TNFSF10 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNFSF10
10/152 Novoseek chemical compound relationships for TNFSF10 gene (see all 152) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tri (d)	81.7	15	10811986 (3), 9563466 (2), 10690508 (2), 10933923 (1) (see all 7)
bortezomib	71	84	19261616 (6), 17326159 (6), 20442297 (6), 19768634 (5) (see all 29)
mg 132	64.8	13	16082182 (2), 12556975 (1), 17252198 (1), 16520654 (1) (see all 9)
suberoylanilide hydroxamic acid	63.4	15	19737941 (3), 17410615 (2), 16273296 (1), 17486365 (1) (see all 9)
ly294002	61.3	27	16722146 (3), 17579344 (2), 18676851 (2), 17868340 (1) (see all 19)
doxorubicin	61.1	145	12800232 (7), 12835727 (6), 16619517 (5), 17649723 (5) (see all 58)
etoposide	61.1	91	16044155 (4), 17441316 (4), 20416058 (3), 15368357 (3) (see all 52)
noxa	61	4	17569614 (1), 19050264 (1), 16888645 (1), 16026644 (1)
sp 600125	60.5	6	17698840 (2), 15286701 (1), 19942932 (1), 16442178 (1)
cycloheximide	54.8	52	10676636 (2), 14632785 (2), 15033719 (2), 16003319 (2) (see all 30)

Search CenterWatch for drugs/clinical trials and news about TNFSF10 / TNF10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNFSF10 gene (3 alternative transcripts):

NM_001190942.1 NM_001190943.1 NM_003810.3

Unigene Cluster for TNFSF10:

Tumor necrosis factor (ligand) superfamily, member 10

Hs.478275 [show with all ESTs]

Unigene Representative Sequence: NM_003810

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000241261(uc003fid.3 uc021xhk.1 uc003fie.3) ENST00000420541

ENST00000430881 ENST00000494851 ENST00000472804 ENST00000466777(uc010hwu.2)

miRNA Products:		OriGene 3'-UTR Clone: TNFSF10 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFSF10
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFSF10:
		hsa-miR-501-5p hsa-miR-876-5p hsa-miR-491-3p hsa-miR-3182 hsa-miR-3647-3p hsa-miR-3167
		SwitchGear 3'UTR luciferase reporter plasmid: TNFSF10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFSF10 (see all 7) OriGene shRNA RFP: TNFSF10 OriGene siRNA: TNFSF10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFSF10

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF10 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFSF10 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): TNFSF10 (NM_003810)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFSF10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFSF10

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFSF10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TNFSF10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFSF10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFSF10

Additional cDNA sequence:

AK296085.1 AK309200.1 AK312742.1 AY312579.1 BC009795.1 BC020220.1 BC032722.1 BT019564.1

CR456895.1 DQ848564.1 EU183231.1 NR_033994.1 U37518.1 U57059.1

17 DOTS entries:

DT.449374 DT.100822130 DT.100769434 DT.40117324 DT.100822135 DT.100658129 DT.95363578 DT.100025860

DT.120854655 DT.120854676 DT.95278015 DT.97819079 DT.100822126 DT.120854632 DT.120854642 DT.95278008

DT.95361049

24/277 AceView cDNA sequences (see all 277):

BP360841 AW303882 BX424920 AA910517 Z36726 CB127043 AA298876 AI656729

AI589336 AA297900 AU137748 BX382031 BX399299 AU136348 AA164632 AW474434

AA669645 CR594331 U57059 AA165094 CB215494 BX378852 BM765007 CR598109

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF10 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d
SP1:											-		-						-						-
SP2:											-		-						-		-				-
SP3:											-		-						-
SP4:													-
SP5:											-		-						-		-		-		-

ECgene alternative splicing isoforms for TNFSF10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNFSF10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGCTGTAG

About this image

TNFSF10 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Adult Endothelial Cells

Blood Brain Barrier, Endothelium

Brain

Blood Brain Barrier

Postnatal Endothelial Cells

Blood Brain Barrier, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

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Natural killer-like cells (Derivation of hemato...)

See TNFSF10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFSF10

SOURCE GeneReport for Unigene cluster: Hs.478275

UniProtKB/Swiss-Prot: TNF10_HUMAN, P50591

Tissue specificity: Widespread; most predominant in spleen, lung and prostate

SABiosciences Expression via Pathway-Focused PCR Arrays including TNFSF10 (see all 21):

HIV Host Response in human mouse rat

TGFB/BMP Signaling Pathway in human mouse rat

Autophagy in human mouse rat

Endothelial Cell Biology in human mouse rat

TGFB Signaling Targets in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF10 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tnfsf10^{1 , 5}	tumor necrosis factor (ligand) superfamily, member 10 less^{1, 5}	75.13(n)¹ 67.05(a)¹		3 (10.82 cM)⁵ 22035¹ NM_009425.2¹ NP_033451.1¹ 27317028⁵
chicken (Gallus gallus)	Aves	TNFSF10¹	tumor necrosis factor (ligand) superfamily, member 10 less	64.32(n) 59.26(a)		378894 NM_204379.1 NP_989710.1
lizard (Anolis carolinensis)	Reptilia	TNFSF10⁶	--	53(a)	1 ↔ 1	3(6244924-6260846)
zebrafish (Danio rerio)	Actinopterygii	tnfsf10¹	tumor necrosis factor (ligand) superfamily, member 10 less	53.94(n) 46.18(a)		436866 NM_001002593.1 NP_001002593.1

ENSEMBL Gene Tree for TNFSF10 (if available)
TreeFam Gene Tree for TNFSF10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TNFSF10 gene

TNFSF11²

TNFSF10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114310068^1,2	F,	--	172222798(+)	`CCAGTG/TGGCCA`	3	--	ds500¹		1		WA	118
rs192531236^1,2		--	172222878(+)	`GAGTTC/TAAGAC`	3	--	ds500¹		0	--	--	--	--
rs2860864^1,2	C,A,	--	172222902(+)	`ATGGCG/AAAACC`	3	--	ds500¹		4		NA WA CSA	7
rs184151439^1,2		--	172222938(+)	`TAGCCA/GGGCAT`	3	--	ds500¹		0	--	--	--	--
rs188899205^1,2		--	172222996(+)	`AAAATC/TGCTTG`	3	--	ds500¹		0	--	--	--	--
rs146120920^1,2		--	172223051(+)	`CACTCC/TAGCCT`	3	--	ds500¹		0	--	--	--	--
rs115596301^1,2	C,F,	--	172223127(+)	`CCATCC/ATTTTC`	3	--	ds500¹		1		WA	118
rs192238826^1,2		--	172223132(+)	`CTTTTC/TCAGTA`	3	--	ds500¹		0	--	--	--	--
rs9859259^1,2	C,F,A,H,	--	172223141(+)	`TATGAA/CCTTAC`	3	--	ds500¹		22		EA NS WA NA CSA	2118
rs112822654^1,2	C,	--	172223206(+)	`TACTG-/GTGA GTAAG`	3	--	ds500¹		1		CSA	2

HapMap Linkage Disequilibrium report for TNFSF10 (172223298 - 172241297 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TNFSF10: --
Human Gene Mutation Database (HGMD): TNFSF10

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TNFSF10 for disorders           About GeneDecksing

OMIM gene information: 603598    OMIM disorders: --

20/165 diseases for TNFSF10 (see all 165):    About MalaCards

caspase-8 deficiency post-transplant lymphoproliferative disease diffuse large b-cell lymphoma thrombotic thrombocytopenic purpura

graft versus host disease non-small cell lung carcinoma b-cell lymphomas anaplastic large cell lymphoma

actinic keratosis non-hodgkin lymphoma soft tissue sarcoma anaplastic astrocytoma

oral cavity cancer primary biliary cirrhosis squamous cell carcinoma malignant mesothelioma

avian influenza cowpox primary effusion lymphoma autoimmune lymphoproliferative syndrome

1 disease from the University of Copenhagen DISEASES database for TNFSF10:

Cancer

10/94 Novoseek disease relationships for TNFSF10 gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	90.9	1385	14555528 (3), 15808757 (3), 10438545 (2), 10947965 (2) (see all 99)
tumors	83.9	2283	12384541 (6), 17437073 (6), 12391182 (5), 10626806 (5) (see all 99)
cancer	76.3	867	15158769 (5), 19664138 (5), 17143496 (5), 20430723 (5) (see all 99)
colon cancer	64.6	94	12168112 (3), 15993848 (3), 11309649 (3), 16153452 (3) (see all 59)
malignant glioma	64	38	14655759 (3), 15110189 (2), 18634847 (2), 19939880 (2) (see all 22)
glioma	58.3	131	18172319 (5), 11593384 (5), 18594532 (5), 17545549 (5) (see all 53)
prostate cancer	57.4	135	16891474 (4), 11857034 (4), 18404675 (3), 11461904 (3) (see all 76)
hepatocellular carcinoma	55.4	53	16792868 (4), 17244456 (2), 12750253 (2), 19497411 (2) (see all 38)
glioblastoma	53.5	40	16622457 (4), 14596484 (3), 15504253 (3), 16357155 (3) (see all 20)
reovirus infections	51.1	3	11687970 (1), 10933724 (1), 17661372 (1)

Genetic Association Database (GAD): TNFSF10
Human Genome Epidemiology (HuGE) Navigator: TNFSF10 (17 documents)

Export disorders for TNFSF10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TNFSF10 gene, integrated from 9 sources (see all 1962):
(articles sorted by number of sources associating them with TNFSF10)

Utopia: connect your pdf to the dynamic
world of online information

Identification and characterization of a new member of the TNF family that induces apoptosis. (PubMed id 8777713)^{1, 2, 3, 9} Wiley S.R....Goodwin R.G. (1995)
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. (PubMed id 8663110)^{1, 2, 3} Pitti R.M....Ashkenazi A. (1996)
Isolation of a TRAIL antagonist from the serum of HIV -infected patients. (PubMed id 21859711)^{1, 2} Schnepple D.J....Badley A.D. (2011)
TNF-related apoptosis inducing ligand (TRAIL) gene polymorphism in Japanese patients with multiple sclerosis. (PubMed id 16040132)^{1, 4} Kikuchi S....Sasaki H. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Three polymorphisms in the 3' UTR of the TRAIL (TNF-related apoptosis-inducing ligand) gene. (PubMed id 11781716)^{1, 4} Gray H.L....Ober C. (2001)
Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. (PubMed id 10549288)^{1, 2} Hymowitz S.G.... de Vos A.M. (1999)
Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation. (PubMed id 10542098)^{1, 2} Mongkolsapaya J.... Screaton G.R. (1999)
2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity. (PubMed id 10485660)^{1, 2} Cha S.-S.... Oh B.-H. (1999)
Surface TRAIL decoy receptor-4 expression is correlat ed with TRAIL resistance in MCF7 breast cancer cells. (PubMed id 15916713)^{1, 9} Sanlioglu A.D....Sanlioglu S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8743	HGNC: 11925	AceView: TNFSF10	Ensembl:ENSG00000121858	euGenes: HUgn8743
ECgene: TNFSF10	Kegg: 8743	H-InvDB: TNFSF10

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TNFSF10	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFSF10	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TNFSF10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TNFSF10 gene:
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GeneCards and IP:
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TNFSF10 Gene

tumor necrosis factor (ligand) superfamily, member 10

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TNFSF10 Gene

tumor necrosis factor (ligand) superfamily, member 10

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