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TNFSF10 Gene

protein-coding GIFtS: 69

GC03M173706

tumor necrosis factor (ligand) superfamily, member 10
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
APO2L ^², ³, ⁵
Apo-2L ^¹, ², ³
CD253 ^¹, ²
TL2 ^¹, ²
TRAIL ^¹, ², ³, ⁵

Descriptions
Apo-2 ligand ^², ³
CD253 antigen ^³
Protein TRAIL ^³
TNF-related apoptosis inducing ligand TRAIL ^²
TNF-related apoptosis-inducing ligand ^³
tumor necrosis factor (ligand) family, member 10 ^²
tumor necrosis factor (ligand) superfamily, member 10 ^²
tumor necrosis factor apoptosis-inducing ligand splice variant delta ^²

External Ids
HGNC: 11925¹
Entrez Gene: 8743²
UniProtKB: P50591³
Ensembl: ENSG00000121858⁷

Search outside databases for aliases for TNFSF10 gene

Previous GC identifers: GC03M169274 GC03M173180 GC03M173625 GC03M173544

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TNFSF10:

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF)

ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but

does not appear to kill normal cells although it is expressed at a significant level in most

normal tissues. This protein binds to several members of TNF receptor superfamily including

TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to

TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors

TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding

of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8,

and caspase 3. [provided by RefSeq]

UniProtKB/Swiss-Prot: TNF10_HUMAN, P50591

Function: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3,

TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be

modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG

that cannot induce apoptosis

Gene Wiki entry for TNFSF10 (TRAIL)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TNFSF10 gene

Entrez Gene cytogenetic band: 3q26 Ensembl cytogenetic band: 3q26.31 HGNC cytogenetic band: 3q26

TNFSF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M173706: (about GC identifiers)

Start:	173,706,158 bp from pter
End:	173,723,963 bp from pter
Size:	17,806 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TNF10_HUMAN, P50591 (See protein sequence)

Recommended Name: Tumor necrosis factor ligand superfamily member 10

Size: 281 amino acids; 32509 Da

Cofactor: Binds 1 zinc ion per trimer

Subunit: Homotrimer

Subcellular location: Membrane; Single-pass type II membrane protein (Potential)

PDB structures from and Proteopedia :

1D0G (3D)

1D2Q (3D)

1D4V (3D)

1DG6 (3D)

1DU3 (3D)

REFSEQ proteins: NP_003801.1

ENSEMBL proteins:

ENSP00000372198 ENSP00000241261

Human Recombinant Proteins

	Invitrogen human recombinant proteins for TNFSF10
	Millipore Purified and/or Recombinant TNFSF10 Protein
	Sigma-Aldrich Proteins for TNFSF10
	R&D Systems Recombinant & Natural Proteins for TNFSF10 (TRAIL/TNFSF10)
	Enzo Life Sciences proteins for TNFSF10
	Recombinant Proteins from Abcam (TRAIL)
	Human Recombinant Proteins from Abnova (TNFSF10)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	EXP	8777713 10894160
GO:0005615	extracellular space	IEA	--
GO:0005625	soluble fraction	TAS	8663110
GO:0005887	integral to plasma membrane	TAS	8663110
GO:0016020	membrane	IEA	--

About this table

Antibodies for TNFSF10:

	Invitrogen Antibodies for TNFSF10
	Millipore Mono- and Polyclonal Antibodies for the study of TNFSF10
	Sigma-Aldrich Antibody Arrays and Antibodies for TNFSF10
	R&D Systems Antibodies for TNFSF10 (TRAIL/TNFSF10)
	Cell Signaling Technology (CST) Antibodies for TNFSF10 (TRAIL)
	Antibodies from Abcam (TRAIL), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TNFSF10)
	Novus Biologicals Antibodies for TNFSF10

Assays for TNFSF10:

	Invitrogen Assays for TNFSF10
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for TNFSF10 (TRAIL/TNFSF10) (see all)
	Enzo Life Sciences assays for TNFSF10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P50591

ProtoNet protein and cluster: P50591

1 Blocks protein family: IPB006052 Tumor Necrosis Factor

UniProtKB/Swiss-Prot: TNF10_HUMAN, P50591

Similarity: Belongs to the tumor necrosis factor family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TNFSF10)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TNFSF10)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003810

Applied Biosystems Silencer® siRNAs for TNFSF10

Sigma-Aldrich siRNA and siRNA Panels for TNFSF10

Sigma-Aldrich shRNA Panels and shRNA for TNFSF10

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003810
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003810
untagged cDNA clones in CMV expression vector (see all 2): BC032722

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003810

UniProtKB/Swiss-Prot: TNF10_HUMAN, P50591

Function: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3,

TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be

modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG

that cannot induce apoptosis

Genatlas biochemistry entry for TNFSF10:

tumor necrosis factor (ligand) superfamily,member 10,TNF-related apoptosis inducing ligand

(TRAIL),predominantly expressed in spleen,lung,prostate

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tnfsf10):

immune system

life span-post-weaning/aging

skeleton

tumorigenesis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005164	tumor necrosis factor receptor binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for TNFSF10 (Your Favorite Gene powered by Ingenuity)

Death Receptor Signaling

GeneDecks TNFSF10 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for TNFSF10

5/113 Interacting proteins for TNFSF10 (ENSP00000372198³ P50591²) via UniProtKB, MINT, and/or STRING (see all 113 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACP5	P13686²	MINT-63835
TNFRSF10B	O14763²	MINT-24897
CASP8	ENSP00000351273³	STRING (score=.999)
FADD	ENSP00000301838³	STRING (score=.999)
TNFRSF10C	ENSP00000349324³	STRING (score=.999)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptosis	IEA	--
GO:0006917	induction of apoptosis	TAS	8663110
GO:0006955	immune response	IEA	--
GO:0007165	signal transduction	TAS	8663110 8777713
GO:0007267	cell-cell signaling	TAS	8777713

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TNFSF10
10/53 Novoseek chemical compound relationships for TNFSF10 gene (see all 53 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tri (d)	82.90	15	10811986 (3), 9563466 (2), 10690508 (2), 10933923 (1) (see all 7)
noxa	63.05	4	17569614 (1), 19050264 (1), 16888645 (1), 16026644 (1)
sp 600125	62.77	5	17698840 (2), 15286701 (1), 16442178 (1)
ifn-alpha	53.18	57	17617740 (6), 17432976 (6), 16736946 (4), 15585621 (3) (see all 10)
8-chloroadenosine	52.67	4	15201983 (2), 16438865 (1), 18097593 (1)
perifosine	50.43	21	19010914 (7), 18698026 (3), 17604333 (1)
phosphatidylinositol	41.52	24	12140294 (7), 10502402 (2), 15684417 (2), 11350953 (1) (see all 14)
dutp	40.50	3	12198711 (1), 19192720 (1)
epoxomicin	40.08	5	16998592 (1), 18341587 (1), 15930365 (1)
ceramide	38.86	41	15197616 (6), 17610065 (5), 16170023 (5), 16636669 (4) (see all 10)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TNFSF10)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TNFSF10)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003810

Sigma-Aldrich siRNA and siRNA Panels for TNFSF10

Sigma-Aldrich shRNA Panels and shRNA for TNFSF10

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003810

REFSEQ mRNAs for TNFSF10 gene:

NM_003810.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003810

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003810
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003810
                                 untagged cDNA clones in CMV expression vector (see all 2): BC032722

Additional cDNA sequence:

AK296085.1 AK309200.1 AK312742.1 AY312579.1 BC009795.1 BC020220.1 BC032722.1 BT019564.1

CR456895.1 CR594331.1 CR598109.1 DQ848564.1 EU183231.1 U37518.1 U57059.1

17 DOTS entries:

DT.449374 DT.100822130 DT.100769434 DT.40117324 DT.100822135 DT.100658129 DT.95363578 DT.100025860

DT.120854655 DT.120854676 DT.95278015 DT.97819079 DT.100822126 DT.120854632 DT.120854642 DT.95278008

DT.95361049

24/277 AceView cDNA sequences (see all 277 ):

AU139518 AI656729 AA176671 AA297900 NM_003810 BM765007 U57059 BX399299

CB127043 AA298876 AU137748 CR598109 AW303882 AA176836 BX382031 AW474434

AA910517 AU136348 AI638788 AA164632 CB215494 BX378852 AI660244 H38776

highest scoring ESTs for TNFSF10:

U37518 AA263133 AA477173 AA494493 AA877776 AI657160 AI660244 AI769552 AU100152 AU121602

Unigene Cluster for TNFSF10:

Tumor necrosis factor (ligand) superfamily, member 10

Hs.478275 [show with all ESTs]

Unigene Representative Sequence: NM_003810

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF10 (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d
SP1:											-		-						-						-
SP2:											-		-						-		-				-
SP3:											-		-						-
SP4:													-
SP5:											-		-						-		-		-		-

About this scheme

ECgene alternative splicing isoforms for TNFSF10

2 Ensembl transcripts including schematic representations:

ENST00000382750 ENST00000241261

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TNFSF10 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TNFSF10

¹ / ² / ³

7 probe-sets matching TNFSF10 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1715_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U37518	1.00	1.00	1.00	1
202687_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U57059	0.80	1.00	0.91	1
202688_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003810	0.60	1.00	0.82	1
214329_x_at²^{, 3}	U133-A	2	0.27	0.83	--	--	AW474434	0.60	1.00	0.82	1
202687_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202688_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214329_x_at²	U133Plus2	2	0.27	0.83	--	--	--	--	--	--	--

GeneDecks TNFSF10 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCACTACACT

SOURCE GeneReport for Unigene cluster: Hs.478275
Expression variation in blood from EXPOLDB for TNFSF10
UniProtKB/Swiss-Prot: TNF10_HUMAN, P50591
Tissue specificity: Widespread; most predominant in spleen, lung and prostate

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TNFSF10 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	TNFSF10¹	--	tumor necrosis factor (ligand) superfamily, member more	99.29(n) 98.93(a)	460852 XM_001165714.1 XP_001165714.1
cow (Bos taurus)	TNFSF10¹	--	tumor necrosis factor (ligand) superfamily, member more	81.5(n) 72.43(a)	507215 XM_583785.3 XP_583785.3
rat (Rattus norvegicus)	Tnfsf10¹	--	tumor necrosis factor (ligand) superfamily, member more	74.35(n) 70.26(a)	246775 NM_145681.1 NP_663714.1
mouse (Mus musculus)	Tnfsf10^{1, 5}	3⁵	tumor necrosis factor (ligand) superfamily, member more^{1, 5}	75(n)¹ 67.05(a)¹	22035¹ NM_009425.2¹ NP_033451.1¹ AB052771⁵ AF470537⁵ (see all 16)
chicken (Gallus gallus)	TNFSF10¹	--	tumor necrosis factor (ligand) superfamily, member more	64.2(n) 59.26(a)	378894 NM_204379.1 NP_989710.1

About this table Species with no ortholog for TNFSF10

ENSEMBL Gene Tree for TNFSF10

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TNFSF10 gene

TNFSF11² ENSG00000188525²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/194 NCBI SNPs in TNFSF10 are shown (see all 194 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 90)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs388515^1,2	A,C,F,H,O	173725441(-)	`ACAGAC/TAGAAG`	1	--	ng3¹ tfbs³		13	EU EA WA NA	1096
--	rs3136586^1,2	A,C,F,H,O	173724453(-)	`ATGGAA/GTTATG`	1	--	ng3¹		9	NA EU EA WA	782
	rs1131542^1,2	A,C,F,H	173706620(-)	`GAAAGC/AGCAAC`	1	--	ut3¹ trp³		9	NA MN EU EA WA	774
	rs365238^1,2	C,F,H,O	173724560(-)	`GGCATA/GTTGTC`	1	--	ng3¹		9	MN EU EA WA NA	784
	rs9859259^1,2	A,C,F,H	173705835(+)	`tatgaA/Ccttac`	1	--	ng5¹		4	EU EA WA	418
	rs3136581^1,2	C,F,H,O	173725855(-)	`GACTTC/TCTGCA`	1	--	ng3¹		12	NA EU EA WA	1020
	rs1131535^1,2	A,C,F,H	173706769(-)	`CAAGAA/GAATGA`	1	--	ut3¹		14	NA MN EA EU WA	1276
	rs432251^1,2	A,C,F,H	173725458(-)	`TAAATG/ATAGAC`	1	--	ng3¹ tfbs³		5	EU EA WA NA	402
	rs17600346^1,2	C,F,H	173706676(+)	`AACCAT/CTGCAT`	1	--	ut3¹		7	NA EU EA WA	562
	rs16845759^1,2	C,F,H	173715474(+)	`TACTTG/TTCCTG`	1	D/E	mis¹ ese³		16	NA EU EA WA	1456

About this table

HapMap Linkage Disequilibrium images for TNFSF10 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603598

10/93 Novoseek disease relationships for TNFSF10 gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	90.47	1208	14555528 (3), 15808757 (3), 10438545 (2), 10947965 (2) (see all 99)
tumors	83.24	2001	12384541 (6), 17437073 (6), 12391182 (5), 10626806 (5) (see all 99)
cancer	75.08	741	15158769 (5), 17143496 (5), 15550937 (5), 15653686 (4) (see all 99)
malignant glioma	62.66	35	14655759 (3), 15110189 (2), 18634847 (2), 16361820 (2) (see all 20)
colon cancer	62.47	87	12168112 (3), 15993848 (3), 11309649 (3), 16153452 (3) (see all 52)
glioma	58.42	120	18172319 (5), 11593384 (5), 18594532 (5), 17545549 (5) (see all 47)
prostate cancer	56.31	120	16891474 (4), 11857034 (4), 18404675 (3), 11461904 (3) (see all 67)
hepatocellular carcinoma	53.78	43	16792868 (4), 17244456 (2), 12750253 (2), 12795833 (2) (see all 33)
glioblastoma	51.60	38	16622457 (4), 14596484 (3), 16357155 (3), 15504253 (3) (see all 18)
colon carcinoma	49.67	25	17143800 (3), 18097875 (3), 12941843 (2), 17431792 (1) (see all 18)

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Genetic Association Database: TNFSF10
Human Genome Epidemiology Navigator: TNFSF10 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1564 PubMed articles for TNFSF10 gene (see all 1564 ):

Identification and characterization of a new member of the TNF family that induces apoptosis. (PubMed id 8777713)^{1, 2, 3, 4} Wiley S.R....Goodwin R.G. (1995)
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. (PubMed id 8663110)^{2, 3, 4} Pitti R.M....Ashkenazi A. (1996)
TNF-related apoptosis inducing ligand (TRAIL) gene polymorphism in Japanese patients with multiple sclerosis. (PubMed id 16040132)^{3, 6} Kikuchi S....Sasaki H. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Three polymorphisms in the 3' UTR of the TRAIL (TNF-related apoptosis-inducing ligand) gene. (PubMed id 11781716)^{3, 6} Gray H.L....Ober C. (2001)
Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. (PubMed id 10549288)^{3, 4} Hymowitz S.G.... de Vos A.M. (1999)
Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation. (PubMed id 10542098)^{3, 4} Mongkolsapaya J.... Screaton G.R. (1999)
2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity. (PubMed id 10485660)^{3, 4} Cha S.-S.... Oh B.-H. (1999)
Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells. (PubMed id 15916713)^{1, 3} Sanlioglu A.D....Sanlioglu S. (2005)
Expression of TNF-related apoptosis-inducing ligand (TRAIL) in megakaryocytes and platelets. (PubMed id 15539085)^{1, 3} Crist S.A....Ratliff T.L. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 8743	HGNC: 11925	AceView: TNFSF10	Ensembl:ENSG00000121858	euGenes: HUgn8743
ECgene: TNFSF10	H-InvDB: TNFSF10

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TNFSF10	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TNFSF10
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TNFSF10:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TNFSF10-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TNFSF10		Antibodies for TNFSF10
	Explore super-pooled esiRNAs		Proteins for TNFSF10
	Lentivirus-delivered shRNAs for TNFSF10		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TNFSF10)
	Antibodies (TNFSF10)
	Chimera RNAi (TNFSF10)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for TNFSF10 (TRAIL)

	Recombinant Proteins (TRAIL)
	Antibodies (TRAIL)

Search OriGene for TNFSF10

Search Tocris compounds for TNFSF10

	Assays/Proteins for TNFSF10
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TNFSF10

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TNFSF10 Gene at Home site.
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TNFSF10 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for TNFSF10

Summaries
for TNFSF10

Genomic Location
for TNFSF10

Proteins
for TNFSF10

Protein Domains/
Families
for TNFSF10

Gene Function
for TNFSF10

Pathways & Interactions
for TNFSF10

Drugs & Compounds
for TNFSF10

Transcripts
for TNFSF10

Expression
for TNFSF10

Orthologs
for TNFSF10

Paralogs
for TNFSF10

SNPs/Variants
for TNFSF10

Disorders & Mutations
for TNFSF10

Medical News
for TNFSF10

Publications
for TNFSF10

Search for TNFSF10

Genome Databases showing TNFSF10

Other Databases showing TNFSF10

Specialized Databases showing TNFSF10

Licensable Technologies
for TNFSF10

Services
for TNFSF10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TNFSF10 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor TNFSF10

Summariesfor TNFSF10

Genomic Locationfor TNFSF10

Proteinsfor TNFSF10

Protein Domains/Familiesfor TNFSF10

Gene Functionfor TNFSF10

Pathways & Interactionsfor TNFSF10

Drugs & Compoundsfor TNFSF10

Transcriptsfor TNFSF10

Expression for TNFSF10

Orthologsfor TNFSF10

Paralogsfor TNFSF10

SNPs/Variantsfor TNFSF10

Disorders & Mutationsfor TNFSF10

Medical Newsfor TNFSF10

Publicationsfor TNFSF10

Search for TNFSF10

Genome Databases showing TNFSF10

Other Databases showing TNFSF10

Specialized Databases showing TNFSF10

Licensable Technologiesfor TNFSF10

Servicesfor TNFSF10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TNFSF10

Summaries
for TNFSF10

Genomic Location
for TNFSF10

Proteins
for TNFSF10

Protein Domains/
Families
for TNFSF10

Gene Function
for TNFSF10

Pathways & Interactions
for TNFSF10

Drugs & Compounds
for TNFSF10

Transcripts
for TNFSF10

Expression
for TNFSF10

Orthologs
for TNFSF10

Paralogs
for TNFSF10

SNPs/Variants
for TNFSF10

Disorders & Mutations
for TNFSF10

Medical News
for TNFSF10

Publications
for TNFSF10

Licensable Technologies
for TNFSF10

Services
for TNFSF10