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Aliases for TNFSF10 Gene

Aliases for TNFSF10 Gene

  • Tumor Necrosis Factor Superfamily Member 10 2 3 5
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 10 2 3
  • Apo-2 Ligand 3 4
  • Apo-2L 3 4
  • APO2L 3 4
  • TRAIL 3 4
  • Tumor Necrosis Factor Apoptosis-Inducing Ligand Splice Variant Delta 3
  • Chemokine Tumor Necrosis Factor Ligand Superfamily Member 10 3
  • Tumor Necrosis Factor (Ligand) Superfamily Member 10 3
  • Tumor Necrosis Factor (Ligand) Family, Member 10 3
  • TNF-Related Apoptosis Inducing Ligand TRAIL 3
  • TNF-Related Apoptosis-Inducing Ligand 4
  • Tumor Necrosis Factor Ligand 6A 3
  • CD253 Antigen 4
  • Protein TRAIL 4
  • TNLG6A 3
  • CD253 3
  • TL2 3

External Ids for TNFSF10 Gene

Previous GeneCards Identifiers for TNFSF10 Gene

  • GC03M169274
  • GC03M173180
  • GC03M173625
  • GC03M173544
  • GC03M173706
  • GC03M172223
  • GC03M169593

Summaries for TNFSF10 Gene

Entrez Gene Summary for TNFSF10 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for TNFSF10 Gene

TNFSF10 (Tumor Necrosis Factor Superfamily Member 10) is a Protein Coding gene. Diseases associated with TNFSF10 include malignant glioma and primary effusion lymphoma. Among its related pathways are Apoptosis Modulation and Signaling and PEDF Induced Signaling. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF11.

UniProtKB/Swiss-Prot for TNFSF10 Gene

  • Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

Gene Wiki entry for TNFSF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF10 Gene

Genomics for TNFSF10 Gene

Regulatory Elements for TNFSF10 Gene

Enhancers for TNFSF10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TNFSF10 on UCSC Golden Path with GeneCards custom track

Promoters for TNFSF10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNFSF10 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNFSF10 Gene

Chromosome:
3
Start:
172,505,508 bp from pter
End:
172,523,507 bp from pter
Size:
18,000 bases
Orientation:
Minus strand

Genomic View for TNFSF10 Gene

Genes around TNFSF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF10 Gene

Proteins for TNFSF10 Gene

  • Protein details for TNFSF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50591-TNF10_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 10
    Protein Accession:
    P50591
    Secondary Accessions:
    • A1Y9B3

    Protein attributes for TNFSF10 Gene

    Size:
    281 amino acids
    Molecular mass:
    32509 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for TNFSF10 Gene

    Alternative splice isoforms for TNFSF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFSF10 Gene

Proteomics data for TNFSF10 Gene at MOPED

Post-translational modifications for TNFSF10 Gene

Other Protein References for TNFSF10 Gene

Antibody Products

  • R&D Systems Antibodies for TNFSF10 (TRAIL/TNFSF10)
  • Cell Signaling Technology (CST) Antibodies for TNFSF10 (TRAIL)

Protein Products

  • Enzo Life Sciences proteins for TNFSF10
  • Cloud-Clone Corp. Proteins for TNFSF10

No data available for DME Specific Peptides for TNFSF10 Gene

Domains & Families for TNFSF10 Gene

Gene Families for TNFSF10 Gene

Protein Domains for TNFSF10 Gene

Graphical View of Domain Structure for InterPro Entry

P50591

UniProtKB/Swiss-Prot:

TNF10_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF10: view

Function for TNFSF10 Gene

Molecular function for TNFSF10 Gene

GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 10,TNF-related apoptosis inducing ligand (TRAIL),predominantly expressed in spleen,lung,prostate
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

Gene Ontology (GO) - Molecular Function for TNFSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10549288
genes like me logo Genes that share ontologies with TNFSF10: view
genes like me logo Genes that share phenotypes with TNFSF10: view

Animal Models for TNFSF10 Gene

MGI Knock Outs for TNFSF10:

Animal Model Products

CRISPR Products

miRNA for TNFSF10 Gene

miRTarBase miRNAs that target TNFSF10

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFSF10 Gene

Localization for TNFSF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF10 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFSF10 Gene COMPARTMENTS Subcellular localization image for TNFSF10 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TNFSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFSF10: view

Pathways & Interactions for TNFSF10 Gene

genes like me logo Genes that share pathways with TNFSF10: view

SIGNOR curated interactions for TNFSF10 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TNFSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0007165 signal transduction TAS 8663110
GO:0007267 cell-cell signaling TAS 8777713
GO:0010939 regulation of necrotic cell death TAS --
GO:0012501 programmed cell death TAS --
genes like me logo Genes that share ontologies with TNFSF10: view

Drugs & Compounds for TNFSF10 Gene

(89) Drugs for TNFSF10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(63) Additional Compounds for TNFSF10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFSF10: view

Transcripts for TNFSF10 Gene

Unigene Clusters for TNFSF10 Gene

Tumor necrosis factor (ligand) superfamily, member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: - - - - - -
SP6:
SP7: - - - - - - - -
SP8: - -

Relevant External Links for TNFSF10 Gene

GeneLoc Exon Structure for
TNFSF10
ECgene alternative splicing isoforms for
TNFSF10

Expression for TNFSF10 Gene

mRNA expression in normal human tissues for TNFSF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFSF10 Gene

This gene is overexpressed in Whole Blood (x7.2) and Minor Salivary Gland (x4.5).

Protein differential expression in normal tissues from HIPED for TNFSF10 Gene

This gene is overexpressed in Milk (45.1) and Islet of Langerhans (18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFSF10 Gene



SOURCE GeneReport for Unigene cluster for TNFSF10 Gene Hs.478275

mRNA Expression by UniProt/SwissProt for TNFSF10 Gene

P50591-TNF10_HUMAN
Tissue specificity: Widespread; most predominant in spleen, lung and prostate.
genes like me logo Genes that share expression patterns with TNFSF10: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for TNFSF10 Gene

Orthologs for TNFSF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TNFSF10 35
  • 80.76 (n)
  • 71.33 (a)
TNFSF10 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNFSF10 35
  • 85.56 (n)
  • 81.59 (a)
TNFSF10 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnfsf10 35
  • 74.84 (n)
  • 66.79 (a)
Tnfsf10 16
Tnfsf10 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNFSF10 35
  • 99.17 (n)
  • 98.93 (a)
TNFSF10 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfsf10 35
  • 74.47 (n)
  • 70.26 (a)
oppossum
(Monodelphis domestica)
Mammalia TNFSF10 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFSF10 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNFSF10 35
  • 64.11 (n)
  • 58.76 (a)
TNFSF10 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFSF10 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfsf10 35
  • 58.4 (n)
  • 49.62 (a)
zebrafish
(Danio rerio)
Actinopterygii tnfsf10 35
  • 54.2 (n)
  • 46.18 (a)
tnfsf10 36
  • 39 (a)
OneToOne
Species with no ortholog for TNFSF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFSF10 Gene

ENSEMBL:
Gene Tree for TNFSF10 (if available)
TreeFam:
Gene Tree for TNFSF10 (if available)

Paralogs for TNFSF10 Gene

Paralogs for TNFSF10 Gene

genes like me logo Genes that share paralogs with TNFSF10: view

Variants for TNFSF10 Gene

Sequence variations from dbSNP and Humsavar for TNFSF10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs6763816 - 172,523,288(+) AGTTA(C/T)AGCCA nc-transcript-variant, reference, missense
rs16845759 - 172,514,990(+) TACTT(G/T)TCCTG nc-transcript-variant, reference, missense
rs179777 -- 172,520,095(-) GAGCT(A/G)CAAGG intron-variant
rs365238 -- 172,524,076(-) GGCAT(A/G)TTGTC upstream-variant-2KB
rs388515 -- 172,524,957(-) ACAGA(C/T)AGAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TNFSF10 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv877987 CNV Loss 21882294
nsv829794 CNV Gain 17160897
nsv877989 CNV Gain 21882294

Variation tolerance for TNFSF10 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFSF10 Gene

HapMap Linkage Disequilibrium report
TNFSF10
Human Gene Mutation Database (HGMD)
TNFSF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF10 Gene

Disorders for TNFSF10 Gene

MalaCards: The human disease database

(17) MalaCards diseases for TNFSF10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malignant glioma
  • glioma
primary effusion lymphoma
  • aids-related lymphoma
ulceroglandular tularemia
pharyngoconjunctival fever
  • adenoviral pharyngoconjunctivitis
mesothelioma, somatic
  • malignant mesothelioma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFSF10

Genetic Association Database (GAD)
TNFSF10
Human Genome Epidemiology (HuGE) Navigator
TNFSF10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFSF10
genes like me logo Genes that share disorders with TNFSF10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF10 Gene

Publications for TNFSF10 Gene

  1. Identification and characterization of a new member of the TNF family that induces apoptosis. (PMID: 8777713) Wiley S.R. … Goodwin R.G. (Immunity 1995) 2 3 4 67
  2. AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators. (PMID: 19896469) GarcA-a-GarcA-a C. … LA^pez-Rivas A. (Biochem. Pharmacol. 2010) 3 23
  3. Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis. (PMID: 20097879) Mader I. … Fulda S. (FASEB J. 2010) 3 23
  4. Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection. (PMID: 20334827) Stegmann K.A. … Wedemeyer H. (Gastroenterology 2010) 3 23
  5. Synergistic effect of celecoxib on TRAIL-induced apoptosis in hepatocellular carcinoma cells. (PMID: 20394499) Lu G. … Wang G. (Cancer Invest. 2010) 3 23

Products for TNFSF10 Gene

Sources for TNFSF10 Gene

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