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Aliases for TNFSF10 Gene

Aliases for TNFSF10 Gene

  • Tumor Necrosis Factor (Ligand) Superfamily, Member 10 2 3
  • APO2L 3 4 6
  • TRAIL 3 4 6
  • Apo-2 Ligand 3 4
  • Apo-2L 3 4
  • Tumor Necrosis Factor Apoptosis-Inducing Ligand Splice Variant Delta 3
  • Chemokine Tumor Necrosis Factor Ligand Superfamily Member 10 3
  • Tumor Necrosis Factor Ligand Superfamily Member 10 3
  • Tumor Necrosis Factor (Ligand) Family, Member 10 3
  • TNF-Related Apoptosis Inducing Ligand TRAIL 3
  • TNF-Related Apoptosis-Inducing Ligand 4
  • CD253 Antigen 4
  • Protein TRAIL 4
  • CD253 3
  • TL2 3

External Ids for TNFSF10 Gene

Summaries for TNFSF10 Gene

Entrez Gene Summary for TNFSF10 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for TNFSF10 Gene

TNFSF10 (Tumor Necrosis Factor (Ligand) Superfamily, Member 10) is a Protein Coding gene. Diseases associated with TNFSF10 include adult medulloblastoma and malignant glioma. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF11.

UniProtKB/Swiss-Prot for TNFSF10 Gene

  • Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis

Gene Wiki entry for TNFSF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF10 Gene

Genomics for TNFSF10 Gene

Genomic Location for TNFSF10 Gene

Start:
172,505,508 bp from pter
End:
172,523,507 bp from pter
Size:
18,000 bases
Orientation:
Minus strand

Genomic View for TNFSF10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFSF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF10 Gene

Regulatory Elements for TNFSF10 Gene

Proteins for TNFSF10 Gene

  • Protein details for TNFSF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50591-TNF10_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 10
    Protein Accession:
    P50591
    Secondary Accessions:
    • A1Y9B3

    Protein attributes for TNFSF10 Gene

    Size:
    281 amino acids
    Molecular mass:
    32509 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per trimer.;
    Quaternary structure:
    • Homotrimer

    Three dimensional structures from OCA and Proteopedia for TNFSF10 Gene

    Alternative splice isoforms for TNFSF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFSF10 Gene

Proteomics data for TNFSF10 Gene at MOPED

Post-translational modifications for TNFSF10 Gene

Other Protein References for TNFSF10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFSF10 Gene

Domains for TNFSF10 Gene

Gene Families for TNFSF10 Gene

HGNC:
  • CD :CD molecules
  • TNFSF :Tumor necrosis factor (ligand) superfamily

Protein Domains for TNFSF10 Gene

Graphical View of Domain Structure for InterPro Entry

P50591

UniProtKB/Swiss-Prot:

TNF10_HUMAN
Family:
  • Belongs to the tumor necrosis factor family.:
    • P50591
genes like me logo Genes that share domains with TNFSF10: view

Function for TNFSF10 Gene

Molecular function for TNFSF10 Gene

GENATLAS Biochemistry: tumor necrosis factor (ligand) superfamily,member 10,TNF-related apoptosis inducing ligand (TRAIL),predominantly expressed in spleen,lung,prostate
UniProtKB/Swiss-Prot Function: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis

Gene Ontology (GO) - Molecular Function for TNFSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8663110
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 10549288
GO:0032813 tumor necrosis factor receptor superfamily binding --
genes like me logo Genes that share ontologies with TNFSF10: view
genes like me logo Genes that share phenotypes with TNFSF10: view

Animal Models for TNFSF10 Gene

MGI Knock Outs for TNFSF10:

miRNA for TNFSF10 Gene

miRTarBase miRNAs that target TNFSF10

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TNFSF10 Gene

Localization for TNFSF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF10 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFSF10 Gene COMPARTMENTS Subcellular localization image for TNFSF10 gene
Compartment Confidence
extracellular 4
plasma membrane 4
cytosol 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TNFSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005887 integral component of plasma membrane TAS 8663110
GO:0016020 membrane --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with TNFSF10: view

Pathways for TNFSF10 Gene

genes like me logo Genes that share pathways with TNFSF10: view

Gene Ontology (GO) - Biological Process for TNFSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 8663110
GO:0007166 cell surface receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TNFSF10: view

Compounds for TNFSF10 Gene

(152) Novoseek inferred chemical compound relationships for TNFSF10 Gene

Compound -log(P) Hits PubMed IDs
tri (d) 81.7 11
bortezomib 71 61
mg 132 64.8 10
suberoylanilide hydroxamic acid 63.4 12
ly294002 61.3 23
genes like me logo Genes that share compounds with TNFSF10: view

Transcripts for TNFSF10 Gene

Unigene Clusters for TNFSF10 Gene

Tumor necrosis factor (ligand) superfamily, member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: - - - - - -
SP6:
SP7: - - - - - - - -
SP8: - -

Relevant External Links for TNFSF10 Gene

GeneLoc Exon Structure for
TNFSF10
ECgene alternative splicing isoforms for
TNFSF10

Expression for TNFSF10 Gene

mRNA expression in normal human tissues for TNFSF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFSF10 Gene

This gene is overexpressed in Whole Blood (7.2) and Minor Salivary Gland (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNFSF10 Gene

SOURCE GeneReport for Unigene cluster for TNFSF10 Gene Hs.478275

mRNA Expression by UniProt/SwissProt for TNFSF10 Gene

P50591-TNF10_HUMAN
Tissue specificity: Widespread; most predominant in spleen, lung and prostate
genes like me logo Genes that share expressions with TNFSF10: view

Orthologs for TNFSF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFSF10 35
  • 99.17 (n)
  • 98.93 (a)
TNFSF10 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNFSF10 35
  • 80.76 (n)
  • 71.33 (a)
TNFSF10 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNFSF10 35
  • 85.56 (n)
  • 81.59 (a)
TNFSF10 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnfsf10 35
  • 74.84 (n)
  • 66.79 (a)
Tnfsf10 16
Tnfsf10 36
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNFSF10 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFSF10 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfsf10 35
  • 74.47 (n)
  • 70.26 (a)
chicken
(Gallus gallus)
Aves TNFSF10 35
  • 64.11 (n)
  • 58.76 (a)
TNFSF10 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFSF10 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfsf10 35
  • 58.4 (n)
  • 49.62 (a)
zebrafish
(Danio rerio)
Actinopterygii tnfsf10 35
  • 54.2 (n)
  • 46.18 (a)
tnfsf10 36
  • 39 (a)
OneToOne
Species with no ortholog for TNFSF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFSF10 Gene

ENSEMBL:
Gene Tree for TNFSF10 (if available)
TreeFam:
Gene Tree for TNFSF10 (if available)

Paralogs for TNFSF10 Gene

Paralogs for TNFSF10 Gene

genes like me logo Genes that share paralogs with TNFSF10: view

Variants for TNFSF10 Gene

Sequence variations from dbSNP and Humsavar for TNFSF10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs179777 -- 172,520,095(-) GAGCT(A/G)CAAGG intron-variant
rs231979 -- 172,520,897(-) tgtgt(A/G)gtgtt intron-variant
rs231980 -- 172,520,856(-) tctat(A/G)tatct intron-variant
rs231981 -- 172,520,708(-) CTCAT(C/T)AGTAT intron-variant
rs231982 -- 172,520,630(-) TATTG(A/C)GTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFSF10 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv877987 CNV Loss 21882294
nsv829794 CNV Gain 17160897
nsv877989 CNV Gain 21882294

Relevant External Links for TNFSF10 Gene

HapMap Linkage Disequilibrium report
TNFSF10
Human Gene Mutation Database (HGMD)
TNFSF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF10 Gene

Disorders for TNFSF10 Gene

(1) University of Copenhagen DISEASES for TNFSF10 Gene

(94) Novoseek inferred disease relationships for TNFSF10 Gene

Disease -log(P) Hits PubMed IDs
necrosis 90.9 164
tumors 83.9 330
cancer 76.3 264
colon cancer 64.6 84
malignant glioma 64 30

Relevant External Links for TNFSF10

Genetic Association Database (GAD)
TNFSF10
Human Genome Epidemiology (HuGE) Navigator
TNFSF10
genes like me logo Genes that share disorders with TNFSF10: view

No data available for UniProtKB/Swiss-Prot for TNFSF10 Gene

Publications for TNFSF10 Gene

  1. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. (PMID: 8663110) Pitti R.M. … Ashkenazi A. (J. Biol. Chem. 1996) 2 3 4
  2. Identification and characterization of a new member of the TNF family that induces apoptosis. (PMID: 8777713) Wiley S.R. … Goodwin R.G. (Immunity 1995) 2 3 4
  3. Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: a new potential therapy for the treatment of melanoma. (PMID: 20417200) Karasic T.B. … Ivanov V.N. (Exp. Cell Res. 2010) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. TNF-related apoptosis inducing ligand (TRAIL) gene polymorphism in Japanese patients with multiple sclerosis. (PMID: 16040132) Kikuchi S. … Sasaki H. (J. Neuroimmunol. 2005) 3 48

Products for TNFSF10 Gene

Sources for TNFSF10 Gene

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