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Aliases for TNFRSF9 Gene

Aliases for TNFRSF9 Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 9 2 3
  • T-Cell Antigen 4-1BB Homolog 3 4
  • 4-1BB Ligand Receptor 3 4
  • T-Cell Antigen ILA 3 4
  • CD137 Antigen 3 4
  • CDw137 3 4
  • CD137 3 4
  • ILA 3 4
  • Interleukin-Activated Receptor, Homolog Of Mouse Ly63 3
  • Tumor Necrosis Factor Receptor Superfamily Member 9 3
  • Induced By Lymphocyte Activation (ILA) 3
  • Homolog Of Mouse 4-1BB 3
  • Receptor Protein 4-1BB 3
  • T Cell Antigen ILA 3
  • Homolog Of) 6
  • Mouse 6
  • 4-1BB 3
  • Ly63 6

External Ids for TNFRSF9 Gene

Previous HGNC Symbols for TNFRSF9 Gene

  • ILA

Previous GeneCards Identifiers for TNFRSF9 Gene

  • GC01M007561
  • GC01M007788
  • GC01M007689
  • GC01M007914
  • GC01M007902
  • GC01M007980
  • GC01M007127

Summaries for TNFRSF9 Gene

Entrez Gene Summary for TNFRSF9 Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF9 Gene

TNFRSF9 (Tumor Necrosis Factor Receptor Superfamily, Member 9) is a Protein Coding gene. Diseases associated with TNFRSF9 include dendritic cell tumor. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include receptor activity and cytokine binding.

UniProtKB/Swiss-Prot for TNFRSF9 Gene

  • Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation

Gene Wiki entry for TNFRSF9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF9 Gene

Genomics for TNFRSF9 Gene

Regulatory Elements for TNFRSF9 Gene

Genomic Location for TNFRSF9 Gene

7,915,871 bp from pter
7,943,165 bp from pter
27,295 bases
Minus strand

Genomic View for TNFRSF9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF9 Gene

Proteins for TNFRSF9 Gene

  • Protein details for TNFRSF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 9
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TNFRSF9 Gene

    255 amino acids
    Molecular mass:
    27899 Da
    Quaternary structure:
    • Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1.

neXtProt entry for TNFRSF9 Gene

Proteomics data for TNFRSF9 Gene at MOPED

Post-translational modifications for TNFRSF9 Gene

  • Ubiquitination at Lys219
  • Glycosylation at Asn138 and Asn149
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF9 Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF9 (4-1BB/TNFRSF9/CD137)

Protein Products

  • Enzo Life Sciences proteins for TNFRSF9
  • Novus Biologicals proteins for TNFRSF9
  • Cloud-Clone Corp. Proteins for TNFRSF9

No data available for DME Specific Peptides for TNFRSF9 Gene

Domains for TNFRSF9 Gene

Gene Families for TNFRSF9 Gene

Protein Domains for TNFRSF9 Gene

Suggested Antigen Peptide Sequences for TNFRSF9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 TNFR-Cys repeats.
  • Contains 4 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF9: view

Function for TNFRSF9 Gene

Molecular function for TNFRSF9 Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 9,cell differentiation antigen CD137 (4-1BB),expressed on B and T cells,inhibiting lymphocyte proliferation,activating apoptosis
UniProtKB/Swiss-Prot Function:
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation

Gene Ontology (GO) - Molecular Function for TNFRSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding --
GO:0019955 cytokine binding IEA --
genes like me logo Genes that share ontologies with TNFRSF9: view
genes like me logo Genes that share phenotypes with TNFRSF9: view

Animal Models for TNFRSF9 Gene

MGI Knock Outs for TNFRSF9:

Animal Model Products

CRISPR Products

miRNA for TNFRSF9 Gene

miRTarBase miRNAs that target TNFRSF9

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNFRSF9 Gene

Localization for TNFRSF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF9 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TNFRSF9 Gene COMPARTMENTS Subcellular localization image for TNFRSF9 gene
Compartment Confidence
plasma membrane 4
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for TNFRSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005887 integral component of plasma membrane TAS 8262389
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF9: view

Pathways for TNFRSF9 Gene

genes like me logo Genes that share pathways with TNFRSF9: view

Pathways by source for TNFRSF9 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for TNFRSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 8639902
GO:0008285 negative regulation of cell proliferation TAS 8639902
GO:0042127 regulation of cell proliferation --
GO:0070207 protein homotrimerization IEA --
GO:2001180 negative regulation of interleukin-10 secretion IEA --
genes like me logo Genes that share ontologies with TNFRSF9: view

Drugs for TNFRSF9 Gene

(1) IUPHAR Ligand for TNFRSF9 Gene

Ligand Type Action Affinity Pubmed IDs
4-1BB ligand None None

(6) Novoseek inferred chemical compound relationships for TNFRSF9 Gene

Compound -log(P) Hits PubMed IDs
ccl3 39.1 1
ionomycin 33.2 1
calcium 4.13 3
tyrosine 0 1
cysteine 0 1
genes like me logo Genes that share compounds with TNFRSF9: view

Transcripts for TNFRSF9 Gene

Unigene Clusters for TNFRSF9 Gene

Tumor necrosis factor receptor superfamily, member 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF9 Gene

No ASD Table

Relevant External Links for TNFRSF9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF9 Gene

mRNA expression in normal human tissues for TNFRSF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF9 Gene

This gene is overexpressed in Whole Blood (16.4) and Spleen (4.1).

Protein differential expression in normal tissues for TNFRSF9 Gene

This gene is overexpressed in Bone (67.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNFRSF9 Gene

SOURCE GeneReport for Unigene cluster for TNFRSF9 Gene Hs.86447

mRNA Expression by UniProt/SwissProt for TNFRSF9 Gene

Tissue specificity: Expressed on the surface of activated T-cells
genes like me logo Genes that share expressions with TNFRSF9: view

Expression partners for TNFRSF9 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for TNFRSF9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNFRSF9 35
  • 80.95 (n)
  • 74.29 (a)
  • 74 (a)
(Canis familiaris)
Mammalia TNFRSF9 35
  • 84.97 (n)
  • 78.04 (a)
  • 78 (a)
(Mus musculus)
Mammalia Tnfrsf9 35
  • 70.03 (n)
  • 59.68 (a)
Tnfrsf9 16
Tnfrsf9 36
  • 56 (a)
(Pan troglodytes)
Mammalia TNFRSF9 35
  • 99.35 (n)
  • 98.82 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tnfrsf9 35
  • 69.73 (n)
  • 60.8 (a)
(Monodelphis domestica)
Mammalia TNFRSF9 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia TNFRSF9 36
  • 47 (a)
(Gallus gallus)
Aves TNFRSF9 35
  • 51.25 (n)
  • 44.86 (a)
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfrsf9 35
  • 49.03 (n)
  • 36.41 (a)
(Danio rerio)
Actinopterygii TNFRSF9 (2 of 2) 36
  • 26 (a)
tnfrsf9a 36
  • 24 (a)
Species with no ortholog for TNFRSF9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF9 Gene

Gene Tree for TNFRSF9 (if available)
Gene Tree for TNFRSF9 (if available)

Paralogs for TNFRSF9 Gene

No data available for Paralogs for TNFRSF9 Gene

Variants for TNFRSF9 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs161803 -- 7,915,729(-) TGCTT(C/T)CAACA downstream-variant-500B
rs161804 -- 7,915,578(-) aaccc(C/T)gcctc downstream-variant-500B
rs161805 -- 7,915,535(-) tggca(C/T)gcacc downstream-variant-500B
rs161812 -- 7,939,388(-) TTCTG(C/T)TGATT intron-variant
rs161813 -- 7,939,125(-) ccaag(C/G)tggtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF9 Gene

Variant ID Type Subtype PubMed ID
nsv871360 CNV Gain 21882294
esv2678721 CNV Deletion 23128226
esv2743452 CNV Deletion 23290073

Relevant External Links for TNFRSF9 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF9 Gene

Disorders for TNFRSF9 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TNFRSF9 Gene in MalaCards »

(1) Disease for TNFRSF9 Gene

(15) Novoseek inferred disease relationships for TNFRSF9 Gene

Disease -log(P) Hits PubMed IDs
necrosis 59.6 43
tumors 46.4 63
goiter nodular 40 1
graft-versus-host disease 34 2
rheumatoid arthritis 27 2

Relevant External Links for TNFRSF9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TNFRSF9: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for TNFRSF9 Gene

Publications for TNFRSF9 Gene

  1. A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family. (PMID: 8262389) Schwarz H. … Lotz M. (Gene 1993) 2 3 4
  2. Molecular and biological characterization of human 4-1BB and its ligand. (PMID: 8088337) Alderson M.R. … Goodwin R.G. (Eur. J. Immunol. 1994) 3 4 23
  3. Characterization of human homologue of 4-1BB and its ligand. (PMID: 7622190) Zhou Z. … Kwon B.S. (Immunol. Lett. 1995) 3 4 23
  4. CD137, a member of the tumor necrosis factor receptor family, is located on chromosome 1p36, in a cluster of related genes, and colocalizes with several malignancies. (PMID: 9207223) Schwarz H. … Lotz M. (Biochem. Biophys. Res. Commun. 1997) 3 23
  5. Strong induction of 4-1BB, a growth and survival promoting costimulatory receptor, in HTLV-1-infected cultured and patients' T cells by the viral Tax oncoprotein. (PMID: 18276843) Pichler K. … Grassmann R. (Blood 2008) 3 23

Products for TNFRSF9 Gene

Sources for TNFRSF9 Gene

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