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TNFRSF9 Gene

protein-coding   GIFtS: 65
GCID: GC01M007980

Tumor Necrosis Factor Receptor Superfamily, Member 9


(Previous symbol: ILA)
  See TNFRSF9-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 91 2     4-1BB2
ILA1 2 3 5     Homolog Of Mouse 4-1BB2
CD1372 3 5     Induced By Lymphocyte Activation (ILA)2
4-1BB Ligand Receptor2 3     Interleukin-Activated Receptor, Homolog Of Mouse Ly632
CDw1372 3     Receptor Protein 4-1BB2
CD137 Antigen2 3     T Cell Antigen ILA2
T-Cell Antigen 4-1BB Homolog2 3     Tumor Necrosis Factor Receptor Superfamily Member 92
T-Cell Antigen ILA2 3     

External Ids:    HGNC: 119241   Entrez Gene: 36042   Ensembl: ENSG000000492497   OMIM: 6022505   UniProtKB: Q070113   

Export aliases for TNFRSF9 gene to outside databases

Previous GC identifers: GC01M007561 GC01M007788 GC01M007689 GC01M007914 GC01M007902 GC01M007127


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFRSF9 Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the
clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes,
enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1
cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have
been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TNFRSF9 Gene:
TNFRSF9 (tumor necrosis factor receptor superfamily, member 9) is a protein-coding gene. Diseases associated with TNFRSF9 include follicular dendritic cell tumor. GO annotations related to this gene include cytokine binding and receptor activity.

UniProtKB/Swiss-Prot: TNR9_HUMAN, Q07011
Function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation

Gene Wiki entry for TNFRSF9 (CD137) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFRSF9 gene promoter:
         Bach2   SREBP-1c   SREBP-1b   c-Ets-1   FOXL1   Max   POU2F1   SREBP-1a   POU2F1a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFRSF9 promoter sequence
   Search Chromatin IP Primers for TNFRSF9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36

TNFRSF9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M007980:  view genomic region     (about GC identifiers)

Start:
7,975,931 bp from pter      End:
8,003,225 bp from pter
Size:
27,295 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TNR9_HUMAN, Q07011 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 9 precursor  
Size: 255 amino acids; 27899 Da
Subunit: Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1

Explore the universe of human proteins at neXtProt for TNFRSF9: NX_Q07011

Explore proteomics data for TNFRSF9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys219
  • Glycosylation2 at Asn138, Asn149
  • Modification sites at PhosphoSitePlus

  • See TNFRSF9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001552.2  
    ENSEMBL proteins: 
     ENSP00000366729   ENSP00000465272   ENSP00000464978  

    TNFRSF9 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TNFRSF9

     
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    TNFRSF9 Assay Products:

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    Cloud-Clone Corp. ELISAs for TNFRSF9
    Cloud-Clone Corp. CLIAs for TNFRSF9
    eBioscience ELISAs for TNFRSF9:  
                        Human sCD137 (s4-1BB) Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: 4-1BB
    Tumour necrosis factor (TNF) receptor family

    3 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR009030 Growth_fac_rcpt_N_dom
     IPR020413 TNFR_9

    Graphical View of Domain Structure for InterPro Entry Q07011

    ProtoNet protein and cluster: Q07011

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNR9_HUMAN, Q07011
    Similarity: Contains 4 TNFR-Cys repeats


    Find genes that share domains with TNFRSF9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR9_HUMAN, Q07011
    Function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation

         Genatlas biochemistry entry for TNFRSF9:
    tumor necrosis factor receptor superfamily,member 9,cell differentiation antigen CD137 (4-1BB),expressed on B and
    T cells,inhibiting lymphocyte proliferation,activating apoptosis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
    GO:0019955cytokine binding IEA--
         
    Find genes that share ontologies with TNFRSF9           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNFRSF9:
     Synthetic lethal with c-Myc af  Synthetic lethal with imatinib 

         11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tnfrsf9):
     cellular  craniofacial  endocrine/exocrine gland  hearing/vestibular/ear  hematopoietic system 
     immune system  integument  mortality/aging  no phenotypic analysis  renal/urinary system 
     vision/eye 

    Find genes that share phenotypes with TNFRSF9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TNFRSF9: Tnfrsf9tm1Byk Tnfrsf9tm1Lpc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFRSF9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNFRSF9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF9

    miRNA
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    miRTarBase miRNAs that target TNFRSF9:
    hsa-mir-335-5p (MIRT017048), hsa-mir-98-5p (MIRT027444)

    Block miRNA regulation of human, mouse, rat TNFRSF9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNFRSF9 (see all 9):
    hsa-miR-579 hsa-miR-1290 hsa-miR-3688-3p hsa-miR-759 hsa-miR-4261 hsa-miR-141* hsa-miR-494 hsa-miR-1914
    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF9

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNR9_HUMAN, Q07011: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular3
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005887integral component of plasma membrane TAS8262389
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with TNFRSF9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFRSF9 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    54-1BB Pathway
    4-1BB Pathway0.54


    Find genes that share SuperPaths with TNFRSF9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFRSF9
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF9 (see all 8)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling
    4-1BB Pathway

    2 BioSystems Pathways for TNFRSF9
        TCR Signaling Pathway
    Downstream signaling in naive CD8+ T cells

    3 Sino Biological Pathways for TNFRSF9
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1 Kegg Pathway  (Kegg details for TNFRSF9):
        Cytokine-cytokine receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF9 (see all 6): 
              Th1/Th2 Response in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFRSF9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for TNFRSF9 (Q070113 ENSP000003667294) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF4P434893, ENSP000003685384I2D: score=3 STRING: ENSP00000368538
    TNFSF9P412733, ENSP000002458174I2D: score=2 STRING: ENSP00000245817
    TRAF2Q129333, ENSP000002476684I2D: score=5 STRING: ENSP00000247668
    LRR1Q96L503, ENSP000002982884I2D: score=1 STRING: ENSP00000298288
    TRAF1Q130773, ENSP000003629944I2D: score=5 STRING: ENSP00000362994
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS8639902
    GO:0008285negative regulation of cell proliferation TAS8639902
    GO:0042127regulation of cell proliferation ----
    GO:0070207protein homotrimerization IEA--
    GO:2001180negative regulation of interleukin-10 secretion IEA--

    Find genes that share ontologies with TNFRSF9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFRSF9 (TNR9)

    1 IUPHAR Ligand for TNFRSF9 (4-1BB)    About this table
    LigandTypeActionAffinityPubmed IDs
    4-1BB ligand
    NoneNone--

    6 Novoseek inferred chemical compound relationships for TNFRSF9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ccl3 39.1 1 15470070 (1)
    ionomycin 33.2 1 12706838 (1)
    calcium 4.13 3 16488622 (2), 16123219 (1)
    tyrosine 0 1 8335927 (1)
    cysteine 0 1 16204238 (1)
    dexamethasone 0 1 9536288 (1)



    Find genes that share compounds with TNFRSF9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNFRSF9 gene: 
    NM_001561.5  

    Unigene Cluster for TNFRSF9:

    Tumor necrosis factor receptor superfamily, member 9
    Hs.86447  [show with all ESTs]
    Unigene Representative Sequence: NM_001561
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377507(uc001aot.3) ENST00000474475 ENST00000492571
    miRNA
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    hsa-miR-579 hsa-miR-1290 hsa-miR-3688-3p hsa-miR-759 hsa-miR-4261 hsa-miR-141* hsa-miR-494 hsa-miR-1914
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      QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF9
      QuantiFast Probe-based Assays in human, mouse, rat TNFRSF9

    Additional mRNA sequence: 

    AK125490.1 BC006196.2 L12964.2 U03397.1 

    3 DOTS entries:

    DT.104964  DT.40117698  DT.92050016 

    Selected AceView cDNA sequences (see all 28):

    BF056988 NM_001561 AA210970 CA308737 AW449076 AI583069 BC006196 AK125490 
    L12964 BU626483 BF064069 CD641590 BE207340 BG436824 BP381234 CD521747 
    BX283080 AI990212 BF509155 BP382461 CD640203 BG058770 AA211393 CD700025 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFRSF9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTGCCAGG
    TNFRSF9 Expression
    About this image


    TNFRSF9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Placenta (Extraembryonic Tissues)
    TNFRSF9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFRSF9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.86447

    UniProtKB/Swiss-Prot: TNR9_HUMAN, Q07011
    Tissue specificity: Expressed on the surface of activated T-cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF9 (see all 6): 
              Th1/Th2 Response in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TNFRSF9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF9 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf91 , 5 tumor necrosis factor receptor superfamily, member more1, 5 70.03(n)1
    59.68(a)1
      4 (81.52 cM)5
    219421  NM_001077509.11  NP_001070977.11 
     1509145625 
    chicken
    (Gallus gallus)
    Aves TNFRSF91 tumor necrosis factor receptor superfamily, member more 51.25(n)
    44.86(a)
      419365  XM_417526.4  XP_417526.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tnfrsf91 tumor necrosis factor receptor superfamily, member more 49.03(n)
    36.41(a)
      100489585  XM_002937465.2  XP_002937511.2 
    zebrafish
    (Danio rerio)
    Actinopterygii TNFRSF9 (2 of 2)6
    tnfrsf9a6
    tumor necrosis factor receptor superfamily, member...
    tumor necrosis factor receptor superfamily, member...
    26(a)
    24(a)
    many → 1
    many → 1
    11(41570024-41577401) ENSDARG00000090728
    23(30244785-30250014) ENSDARG00000060498


    ENSEMBL Gene Tree for TNFRSF9 (if available)
    TreeFam Gene Tree for TNFRSF9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFRSF9 (see all 693)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354784
    A colorectal cancer sample4--see VAR_0354782 E G mis40--------
    rs715673291,2
    C--7132244(+) ATTCC-/AT/ATAT
    ATATATATAT
    ATATA
    1 -- int11NA 2
    rs1385142641,2
    --7975476(+) AGAGTA/CTCGCT 1 -- ds50010--------
    rs1419613681,2
    --7975551(+) CAAGTC/GATTTT 1 -- ds50010--------
    rs1618051,2
    C,F,A,H--7975595(-) tggcaT/Cgcacc 1 -- ds50013Minor allele frequency- C:0.20NA 10
    rs1618041,2
    C,F,H--7975638(-) aacccC/Tgcctc 1 -- ds50018Minor allele frequency- T:0.11NA WA CSA 18
    rs767722991,2
    F--7975783(+) GTCAAT/CTGTTG 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1618031,2
    C,F,A,H--7975789(-) TGCTTT/CCAACA 1 -- ds500124Minor allele frequency- C:0.39NS EA NA WA CSA 2686
    rs1492810371,2
    --7975826(+) AGCATA/CCTTCG 1 -- ds50010--------
    rs1932180241,2
    --7975926(+) TAAAAA/TAAGGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TNFRSF9 (7975931 - 8003225 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TNFRSF9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678721CNV Deletion23128226
    esv2743452CNV Deletion23290073
    nsv871360CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFRSF9
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602250    OMIM disorders: --

    1 disease for TNFRSF9:    
    About MalaCards
    follicular dendritic cell tumor


    Find genes that share disorders with TNFRSF9           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TNFRSF9 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 59.6 59 9045669 (3), 9464265 (2), 18668547 (2), 16123219 (2) (see all 37)
    tumors 46.4 85 14716821 (4), 17990986 (3), 19773745 (3), 9045669 (3) (see all 45)
    goiter nodular 40 1 16459462 (1)
    graft-versus-host disease 34 3 11207270 (2)
    rheumatoid arthritis 27 3 18668547 (1), 15031666 (1)
    autoimmune diseases 25.6 5 16002686 (1), 16443548 (1), 12695569 (1)
    asthma allergic 13.1 1 11447378 (1)
    graves disease 7.56 2 16232366 (1), 16459462 (1)
    inflammation 3.06 3 19233196 (1), 19104082 (1)
    solid tumor 2.82 2 10946324 (1)

    Genetic Association Database (GAD): TNFRSF9
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF9 (9 documents)

    Export disorders for TNFRSF9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFRSF9 gene, integrated from 10 sources (see all 216):
    (articles sorted by number of sources associating them with TNFRSF9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family. (PubMed id 8262389)1, 2, 3 Schwarz H.... Lotz M. (Gene 1993)
    2. Molecular and biological characterization of human 4-1BB and its ligand. (PubMed id 8088337)1, 2, 9 Alderson M.R.... Goodwin R.G. (Eur. J. Immunol. 1994)
    3. Characterization of human homologue of 4-1BB and its ligand. (PubMed id 7622190)1, 2, 9 Zhou Z....Kwon B.S. (Immunol. Lett. 1995)
    4. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    7. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    8. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3604 HGNC: 11924 AceView: TNFRSF9 Ensembl:ENSG00000049249 euGenes: HUgn3604
    ECgene: TNFRSF9 Kegg: 3604 H-InvDB: TNFRSF9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNFRSF9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF9 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf9/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFRSF9 gene:
    Search GeneIP for patents involving TNFRSF9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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