Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TNFRSF9 Gene

Aliases for TNFRSF9 Gene

  • TNF Receptor Superfamily Member 9 2 3 5
  • T-Cell Antigen 4-1BB Homolog 3 4
  • 4-1BB Ligand Receptor 3 4
  • CD137 Antigen 3 4
  • CDw137 3 4
  • CD137 3 4
  • ILA 3 4
  • Interleukin-Activated Receptor, Homolog Of Mouse Ly63 3
  • Tumor Necrosis Factor Receptor Superfamily, Member 9 2
  • Tumor Necrosis Factor Receptor Superfamily Member 9 3
  • Induced By Lymphocyte Activation (ILA) 3
  • Homolog Of Mouse 4-1BB 3
  • Receptor Protein 4-1BB 3
  • T Cell Antigen ILA 3
  • T-Cell Antigen ILA 4
  • 4-1BB 3

External Ids for TNFRSF9 Gene

Previous HGNC Symbols for TNFRSF9 Gene

  • ILA

Previous GeneCards Identifiers for TNFRSF9 Gene

  • GC01M007561
  • GC01M007788
  • GC01M007689
  • GC01M007914
  • GC01M007902
  • GC01M007980
  • GC01M007127

Summaries for TNFRSF9 Gene

Entrez Gene Summary for TNFRSF9 Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF9 Gene

TNFRSF9 (TNF Receptor Superfamily Member 9) is a Protein Coding gene. Diseases associated with TNFRSF9 include Retroperitoneal Hemangiopericytoma and Colorectal Cancer. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Akt Signaling. GO annotations related to this gene include receptor activity and cytokine binding.

UniProtKB/Swiss-Prot for TNFRSF9 Gene

  • Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Gene Wiki entry for TNFRSF9 Gene

Additional gene information for TNFRSF9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF9 Gene

Genomics for TNFRSF9 Gene

Regulatory Elements for TNFRSF9 Gene

Enhancers for TNFRSF9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H007703 1.7 FANTOM5 Ensembl ENCODE 10.1 +238.3 238288 2.3 ATF1 ARNT ZNF121 GLIS2 ZNF143 KLF7 FOS ATF7 SP3 SP5 PER3 ENSG00000270171 VAMP3 SLC45A1 ENSG00000236266 TNFRSF9 CAMTA1 LOC105376689
GH01H008002 1.6 Ensembl ENCODE dbSUPER 10.4 -61.8 -61797 4.3 HDGF PKNOX1 FOXA2 ARNT ZFP64 SIN3A FEZF1 ZNF2 YY1 FOS ENSG00000238290 PARK7 ERRFI1 SLC45A1 LINC01714 RNU1-7P TNFRSF9 UTS2 PER3 GC01P008012
GH01H007993 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -50.9 -50886 1.8 BACH1 ZBTB40 BATF ZNF121 ZNF366 EED ATF7 ZSCAN29 NFE2 ETV6 ENSG00000238290 PARK7 ERRFI1 SLC45A1 TNFRSF9 PER3 VAMP3 ENSG00000284747 ENSG00000284716
GH01H008010 1.2 FANTOM5 ENCODE dbSUPER 10.4 -67.1 -67067 0.3 PAF1 TFAP4 ARID4B CHD7 NR2F2 KAT8 POLR2A ETV4 ZNF600 MIXL1 SLC45A1 PARK7 TNFRSF9 ERRFI1 PER3 GC01P008012 ENSG00000284716
GH01H008283 1.1 FANTOM5 ENCODE 10.2 -340.4 -340415 1.1 BATF ZNF316 POLR2A EED ATF7 RUNX3 IKZF2 CREM MAFK MAZ SLC45A1 TNFRSF9 RNU6-991P GC01M008275
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFRSF9 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TNFRSF9 Gene

Genomic Locations for TNFRSF9 Gene
27,295 bases
Minus strand

Genomic View for TNFRSF9 Gene

Genes around TNFRSF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF9 Gene

Proteins for TNFRSF9 Gene

  • Protein details for TNFRSF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 9
    Protein Accession:

    Protein attributes for TNFRSF9 Gene

    255 amino acids
    Molecular mass:
    27899 Da
    Quaternary structure:
    • Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1.

neXtProt entry for TNFRSF9 Gene

Post-translational modifications for TNFRSF9 Gene

  • Ubiquitination at Lys219
  • Glycosylation at posLast=138138 and posLast=149149
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF9 Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF9 (4-1BB/TNFRSF9/CD137)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF9 (TNFRSF9)
  • Abcam antibodies for TNFRSF9

Protein Products

  • Novus Biologicals proteins for TNFRSF9
  • Abcam proteins for TNFRSF9

Assay Products

  • Cloud-Clone Corp. Assay Kits for TNFRSF9
  • Abcam assays for TNFRSF9

No data available for DME Specific Peptides for TNFRSF9 Gene

Domains & Families for TNFRSF9 Gene

Gene Families for TNFRSF9 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TNFRSF9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFRSF9: view

No data available for UniProtKB/Swiss-Prot for TNFRSF9 Gene

Function for TNFRSF9 Gene

Molecular function for TNFRSF9 Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 9,cell differentiation antigen CD137 (4-1BB),expressed on B and T cells,inhibiting lymphocyte proliferation,activating apoptosis
UniProtKB/Swiss-Prot Function:
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Phenotypes From GWAS Catalog for TNFRSF9 Gene

Gene Ontology (GO) - Molecular Function for TNFRSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 8262389
GO:0005031 tumor necrosis factor-activated receptor activity IBA --
GO:0019955 cytokine binding IEA --
genes like me logo Genes that share ontologies with TNFRSF9: view
genes like me logo Genes that share phenotypes with TNFRSF9: view

Animal Models for TNFRSF9 Gene

MGI Knock Outs for TNFRSF9:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF9 Gene

Localization for TNFRSF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF9 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF9 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 2
mitochondrion 1
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNFRSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8262389
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF9: view

Pathways & Interactions for TNFRSF9 Gene

genes like me logo Genes that share pathways with TNFRSF9: view

Gene Ontology (GO) - Biological Process for TNFRSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 8639902
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007275 multicellular organism development IBA --
GO:0008285 negative regulation of cell proliferation IEA,TAS --
genes like me logo Genes that share ontologies with TNFRSF9: view

No data available for SIGNOR curated interactions for TNFRSF9 Gene

Drugs & Compounds for TNFRSF9 Gene

(9) Drugs for TNFRSF9 Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Urelumab Investigational Pharma inhibitor 0
4-1BB ligand Pharma 0
BMS-663513 Pharma Antibody Immunomodulatory agents 0
genes like me logo Genes that share compounds with TNFRSF9: view

Transcripts for TNFRSF9 Gene

Unigene Clusters for TNFRSF9 Gene

Tumor necrosis factor receptor superfamily, member 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF9 Gene

No ASD Table

Relevant External Links for TNFRSF9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF9 Gene

This gene is overexpressed in Whole Blood (x16.4) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for TNFRSF9 Gene

This gene is overexpressed in Bone (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF9 Gene

Protein tissue co-expression partners for TNFRSF9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF9 Gene:


SOURCE GeneReport for Unigene cluster for TNFRSF9 Gene:


mRNA Expression by UniProt/SwissProt for TNFRSF9 Gene:

Tissue specificity: Expressed on the surface of activated T-cells.

Evidence on tissue expression from TISSUES for TNFRSF9 Gene

  • Blood(4.6)
  • Kidney(4.3)
  • Lymph node(2.6)
  • Spleen(2.6)
genes like me logo Genes that share expression patterns with TNFRSF9: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF9 Gene

Orthologs for TNFRSF9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFRSF9 33 34
  • 99.35 (n)
(Canis familiaris)
Mammalia TNFRSF9 33 34
  • 84.97 (n)
(Bos Taurus)
Mammalia TNFRSF9 33 34
  • 80.95 (n)
(Mus musculus)
Mammalia Tnfrsf9 33 16 34
  • 70.03 (n)
(Rattus norvegicus)
Mammalia Tnfrsf9 33
  • 69.73 (n)
(Monodelphis domestica)
Mammalia TNFRSF9 34
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia TNFRSF9 34
  • 47 (a)
(Gallus gallus)
Aves TNFRSF9 33 34
  • 51.25 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfrsf9 33
  • 49.03 (n)
(Danio rerio)
Actinopterygii TNFRSF9 (2 of 2) 34
  • 26 (a)
tnfrsf9a 34
  • 24 (a)
Species where no ortholog for TNFRSF9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF9 Gene

Gene Tree for TNFRSF9 (if available)
Gene Tree for TNFRSF9 (if available)

Paralogs for TNFRSF9 Gene

No data available for Paralogs for TNFRSF9 Gene

Variants for TNFRSF9 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs776878260 A colorectal cancer sample 7,920,854(+) CTCCT(C/T)CTTCT reference, missense
rs9657963 Benign 7,938,763(-) CCAGC(A/G)CAGGT reference, missense
rs1000050617 -- 7,922,746(+) GGCAG(A/T)GGTTG intron-variant
rs1000115443 -- 7,937,726(+) GATCG(C/T)TAAAT reference, missense
rs1000116961 -- 7,920,665(+) AAAAG(G/T)GGTGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF9 Gene

Variant ID Type Subtype PubMed ID
esv2678721 CNV deletion 23128226
esv2743452 CNV deletion 23290073
esv3585133 CNV loss 21293372

Variation tolerance for TNFRSF9 Gene

Residual Variation Intolerance Score: 70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF9 Gene

Disorders for TNFRSF9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TNFRSF9 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retroperitoneal hemangiopericytoma
colorectal cancer
  • colorectal cancer, somatic
sciatic neuropathy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFRSF9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TNFRSF9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF9 Gene

Publications for TNFRSF9 Gene

  1. Characterization of human homologue of 4-1BB and its ligand. (PMID: 7622190) Zhou Z … Kwon BS (Immunology letters 1995) 3 4 22 60
  2. Molecular and biological characterization of human 4-1BB and its ligand. (PMID: 8088337) Alderson MR … Din WS (European journal of immunology 1994) 3 4 22 60
  3. A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family. (PMID: 8262389) Schwarz H … Lotz M (Gene 1993) 2 3 4 60
  4. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee KM … Lan Q (American journal of hematology 2010) 3 45 60
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60

Products for TNFRSF9 Gene

Sources for TNFRSF9 Gene

Loading form....