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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF9 Gene

protein-coding   GIFtS: 63
GCID: GC01M007980

Tumor Necrosis Factor Receptor Superfamily, Member 9


(Previous symbol: ILA)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 91 2     4-1BB2
ILA1 2 3 5     Homolog Of Mouse 4-1BB2
CD1372 3 5     Induced By Lymphocyte Activation (ILA)2
4-1BB Ligand Receptor2 3     Interleukin-Activated Receptor, Homolog Of Mouse Ly632
CDw1372 3     Receptor Protein 4-1BB2
CD137 Antigen2 3     T Cell Antigen ILA2
T-Cell Antigen 4-1BB Homolog2 3     Tumor Necrosis Factor Receptor Superfamily Member 92
T-Cell Antigen ILA2 3     

External Ids:    HGNC: 119241   Entrez Gene: 36042   Ensembl: ENSG000000492497   OMIM: 6022505   UniProtKB: Q070113   

Export aliases for TNFRSF9 gene to outside databases

Previous GC identifers: GC01M007561 GC01M007788 GC01M007689 GC01M007914 GC01M007902 GC01M007127


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF9 Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the
clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes,
enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1
cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have
been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TNFRSF9 Gene: 
TNFRSF9 (tumor necrosis factor receptor superfamily, member 9) is a protein-coding gene. Diseases associated with TNFRSF9 include eosinophilic disorders, and human monocytic ehrlichiosis, and among its related super-pathways are TNF Signaling and STAT3 Pathway. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot: TNR9_HUMAN, Q07011
Function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation

Gene Wiki entry for TNFRSF9 (CD137) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF9 gene promoter:
         Bach2   SREBP-1c   SREBP-1b   c-Ets-1   FOXL1   Max   POU2F1   SREBP-1a   POU2F1a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNFRSF9 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36

TNFRSF9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M007980:  view genomic region     (about GC identifiers)

Start:
7,975,931 bp from pter      End:
8,003,225 bp from pter
Size:
27,295 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNR9_HUMAN, Q07011 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 9 precursor  
Size: 255 amino acids; 27899 Da
Subunit: Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1
Subcellular location: Membrane; Single-pass type I membrane protein

Explore the universe of human proteins at neXtProt for TNFRSF9: NX_Q07011

Explore proteomics data for TNFRSF9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q07011

  • TNFRSF9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNFRSF9 Protein Expression
    REFSEQ proteins: NP_001552.2  
    ENSEMBL proteins: 
     ENSP00000366729   ENSP00000465272   ENSP00000464978  

    Human Recombinant Protein Products for TNFRSF9: 
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    Sino Biological Cell Lysate for TNFRSF9 
    ProSpec Recombinant Protein for TNFRSF9
    Cloud-Clone Corp. Proteins for TNFRSF9 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005887integral to plasma membrane TAS8262389
    GO:0009897external side of plasma membrane IEA--

    TNFRSF9 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for TNFRSF9 
    Cloud-Clone Corp. CLIAs for TNFRSF9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: 4-1BB 
    Tumour necrosis factor (TNF) receptor family

    2 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR020413 TNFR_9

    Graphical View of Domain Structure for InterPro Entry Q07011

    ProtoNet protein and cluster: Q07011

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNR9_HUMAN, Q07011
    Similarity: Contains 4 TNFR-Cys repeats


    TNFRSF9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR9_HUMAN, Q07011
    Function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation

         Genatlas biochemistry entry for TNFRSF9:
    tumor necrosis factor receptor superfamily,member 9,cell differentiation antigen CD137 (4-1BB),expressed on B and
    T cells,inhibiting lymphocyte proliferation,activating apoptosis

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
    GO:0019955cytokine binding IEA--
         
    TNFRSF9 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNFRSF9:
     Synthetic lethal with c-Myc af  Synthetic lethal with imatinib 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tnfrsf9):
     cellular  craniofacial  endocrine/exocrine gland  hearing/vestibular/ear  hematopoietic system 
     immune system  integument  mortality/aging  no phenotypic analysis  renal/urinary system 
     vision/eye 

    TNFRSF9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tnfrsf9tm1Byk for TNFRSF9

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNFRSF9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNFRSF9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF9 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF9 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of TNFRSF9 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNFRSF9 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    54-1BB Pathway
    4-1BB Pathway0.54

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFRSF9
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF9 (see all 8)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling
    4-1BB Pathway

    2 BioSystems Pathways for TNFRSF9
        TCR Signaling Pathway
    Downstream signaling in naive CD8+ T cells

    3 Sino Biological Pathways for TNFRSF9 
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1         Kegg Pathway  (Kegg details for TNFRSF9):
        Cytokine-cytokine receptor interaction


    TNFRSF9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/12 Interacting proteins for TNFRSF9 (Q070113 ENSP000003667294) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF4P434893, ENSP000003685384I2D: score=3 STRING: ENSP00000368538
    TRAF2Q129333, ENSP000002476684I2D: score=5 STRING: ENSP00000247668
    TNFSF9P412733, ENSP000002458174I2D: score=2 STRING: ENSP00000245817
    TRAF1Q130773, ENSP000003629944I2D: score=5 STRING: ENSP00000362994
    TRAF3Q131143, ENSP000003324684I2D: score=5 STRING: ENSP00000332468
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS8639902
    GO:0008285negative regulation of cell proliferation TAS8639902
    GO:0042127regulation of cell proliferation ----
    GO:0070207protein homotrimerization IEA--
    GO:2001180negative regulation of interleukin-10 secretion IEA--

    TNFRSF9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNFRSF9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFRSF9 (TNR9)

    1 IUPHAR Ligand for TNFRSF9 (4-1BB)    About this table 
    LigandTypeActionAffinityPubmed IDs
    4-1BB ligand
    NoneNone--

    6 Novoseek inferred chemical compound relationships for TNFRSF9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ccl3 39.1 1 15470070 (1)
    ionomycin 33.2 1 12706838 (1)
    calcium 4.13 3 16488622 (2), 16123219 (1)
    tyrosine 0 1 8335927 (1)
    cysteine 0 1 16204238 (1)
    dexamethasone 0 1 9536288 (1)

    Search CenterWatch for drugs/clinical trials and news about TNFRSF9 / TNR9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNFRSF9 gene: 
    NM_001561.5  

    Unigene Cluster for TNFRSF9:

    Tumor necrosis factor receptor superfamily, member 9
    Hs.86447  [show with all ESTs]
    Unigene Representative Sequence: NM_001561
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377507(uc001aot.3) ENST00000474475 ENST00000492571
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK125490.1 BC006196.2 L12964.2 U03397.1 

    3 DOTS entries:

    DT.104964  DT.40117698  DT.92050016 

    24/28 AceView cDNA sequences (see all 28):

    AA210970 BC006196 NM_001561 AI583069 AW449076 CA308737 BF056988 BF509155 
    BE207340 BP382461 CD521747 BP381234 CD641590 BF064069 L12964 BU626483 
    AI990212 AK125490 BG436824 BX283080 AA211393 BG058770 CD640203 CD700025 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFRSF9 expression in normal human tissues (normalized intensities)      TNFRSF9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTGCCAGG
    TNFRSF9 Expression
    About this image


    TNFRSF9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Blood (Hematopoietic System)
             cd4+ t cells   
     
     Brain (Nervous System)
             Ciliary Ganglion   
     
     Placenta (Extraembryonic Tissues)

    See TNFRSF9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFRSF9

    SOURCE GeneReport for Unigene cluster: Hs.86447

    UniProtKB/Swiss-Prot: TNR9_HUMAN, Q07011
    Tissue specificity: Expressed on the surface of activated T-cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF9 (see all 6): 
              Th1/Th2 Response in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF9 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf91 , 5 tumor necrosis factor receptor superfamily, member more1, 5 70.03(n)1
    59.68(a)1
      4 (81.52 cM)5
    219421  NM_001077509.11  NP_001070977.11 
     1509145625 
    chicken
    (Gallus gallus)
    Aves TNFRSF91 tumor necrosis factor receptor superfamily, member more 51.09(n)
    43.46(a)
      419365  XM_417526.3  XP_417526.3 
    zebrafish
    (Danio rerio)
    Actinopterygii tnfrsf9a1 tumor necrosis factor receptor superfamily, member more 44.59(n)
    34.42(a)
      678622  NM_001040369.1  NP_001035459.1 


    ENSEMBL Gene Tree for TNFRSF9 (if available)
    TreeFam Gene Tree for TNFRSF9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/693 SNPs in TNFRSF9 are shown (see all 693)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354784
    A colorectal cancer sample4--see VAR_0354782 E G mis40--------
    rs715673291,2
    C--7132244(+) ATTCC-/AT/ATAT
    ATATATATAT
    ATATA
    1 -- int11NA 2
    rs1385142641,2
    --7975476(+) AGAGTA/CTCGCT 1 -- ds50010--------
    rs1419613681,2
    --7975551(+) CAAGTC/GATTTT 1 -- ds50010--------
    rs1618051,2
    C,F,A,H--7975595(-) tggcaT/Cgcacc 1 -- ds50013Minor allele frequency- C:0.20NA 10
    rs1618041,2
    C,F,H--7975638(-) aacccC/Tgcctc 1 -- ds50018Minor allele frequency- T:0.11NA WA CSA 18
    rs767722991,2
    F--7975783(+) GTCAAT/CTGTTG 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1618031,2
    C,F,A,H--7975789(-) TGCTTT/CCAACA 1 -- ds500124Minor allele frequency- C:0.39NS EA NA WA CSA 2686
    rs1492810371,2
    --7975826(+) AGCATA/CCTTCG 1 -- ds50010--------
    rs1932180241,2
    --7975926(+) TAAAAA/TAAGGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TNFRSF9 (7975931 - 8003225 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TNFRSF9:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678721CNV Deletion23128226
    esv2743452CNV Deletion23290073
    nsv871360CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602250    OMIM disorders: --

    20/43 diseases for TNFRSF9 (see all 43):    About MalaCards
    eosinophilic disorders    human monocytic ehrlichiosis    bronchogenic carcinoma    follicular dendritic cell tumor
    autoimmune myocarditis    ehrlichiosis    allergic conjunctivitis    myocarditis
    typhoid fever    graves' disease    conjunctivitis    goiter
    wegener's granulomatosis    respiratory failure    hiv type 1    graft versus host disease
    severe combined immunodeficiency    celiac disease    acute pancreatitis    acute lymphoblastic leukemia


    TNFRSF9 for disorders           About GeneDecksing

    10/15 Novoseek inferred disease relationships for TNFRSF9 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 59.6 59 9045669 (3), 9464265 (2), 18668547 (2), 16123219 (2) (see all 37)
    tumors 46.4 85 14716821 (4), 17990986 (3), 19773745 (3), 9045669 (3) (see all 45)
    goiter nodular 40 1 16459462 (1)
    graft-versus-host disease 34 3 11207270 (2)
    rheumatoid arthritis 27 3 18668547 (1), 15031666 (1)
    autoimmune diseases 25.6 5 16002686 (1), 16443548 (1), 12695569 (1)
    asthma allergic 13.1 1 11447378 (1)
    graves disease 7.56 2 16232366 (1), 16459462 (1)
    inflammation 3.06 3 19233196 (1), 19104082 (1)
    solid tumor 2.82 2 10946324 (1)

    Genetic Association Database (GAD): TNFRSF9
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF9 (9 documents)

    Export disorders for TNFRSF9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFRSF9 gene, integrated from 9 sources (see all 212):
    (articles sorted by number of sources associating them with TNFRSF9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family. (PubMed id 8262389)1, 2, 3 Schwarz H.... Lotz M. (1993)
    2. Molecular and biological characterization of human 4-1BB and its ligand. (PubMed id 8088337)1, 2, 9 Alderson M.R.... Goodwin R.G. (1994)
    3. Characterization of human homologue of 4-1BB and its ligand. (PubMed id 7622190)1, 2, 9 Zhou Z....Kwon B.S. (1995)
    4. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    7. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    8. Common genetic variants in candidate genes and risk o f familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (2009)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    10. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3604 HGNC: 11924 AceView: TNFRSF9 Ensembl:ENSG00000049249 euGenes: HUgn3604
    ECgene: TNFRSF9 Kegg: 3604 H-InvDB: TNFRSF9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFRSF9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF9 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf9/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNFRSF9 gene:
    Search GeneIP for patents involving TNFRSF9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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