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Aliases for TNFRSF9 Gene

Aliases for TNFRSF9 Gene

  • Tumor Necrosis Factor Receptor Superfamily Member 9 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 9 2 3
  • T-Cell Antigen 4-1BB Homolog 3 4
  • 4-1BB Ligand Receptor 3 4
  • T-Cell Antigen ILA 3 4
  • CD137 Antigen 3 4
  • CDw137 3 4
  • CD137 3 4
  • ILA 3 4
  • Interleukin-Activated Receptor, Homolog Of Mouse Ly63 3
  • Induced By Lymphocyte Activation (ILA) 3
  • Homolog Of Mouse 4-1BB 3
  • Receptor Protein 4-1BB 3
  • T Cell Antigen ILA 3
  • 4-1BB 3

External Ids for TNFRSF9 Gene

Previous HGNC Symbols for TNFRSF9 Gene

  • ILA

Previous GeneCards Identifiers for TNFRSF9 Gene

  • GC01M007561
  • GC01M007788
  • GC01M007689
  • GC01M007914
  • GC01M007902
  • GC01M007980
  • GC01M007127

Summaries for TNFRSF9 Gene

Entrez Gene Summary for TNFRSF9 Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF9 Gene

TNFRSF9 (Tumor Necrosis Factor Receptor Superfamily Member 9) is a Protein Coding gene. Diseases associated with TNFRSF9 include Retroperitoneal Hemangiopericytoma and Multiple Sclerosis 4. Among its related pathways are TNF Signaling (sino) and ERK Signaling. GO annotations related to this gene include receptor activity and cytokine binding.

UniProtKB/Swiss-Prot for TNFRSF9 Gene

  • Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Gene Wiki entry for TNFRSF9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF9 Gene

Genomics for TNFRSF9 Gene

Regulatory Elements for TNFRSF9 Gene

Enhancers for TNFRSF9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TNFRSF9 on UCSC Golden Path with GeneCards custom track

Promoters for TNFRSF9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNFRSF9 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNFRSF9 Gene

7,915,871 bp from pter
7,943,165 bp from pter
27,295 bases
Minus strand

Genomic View for TNFRSF9 Gene

Genes around TNFRSF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF9 Gene

Proteins for TNFRSF9 Gene

  • Protein details for TNFRSF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 9
    Protein Accession:

    Protein attributes for TNFRSF9 Gene

    255 amino acids
    Molecular mass:
    27899 Da
    Quaternary structure:
    • Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1.

neXtProt entry for TNFRSF9 Gene

Proteomics data for TNFRSF9 Gene at MOPED

Post-translational modifications for TNFRSF9 Gene

  • Ubiquitination at Lys 219
  • Glycosylation at Asn 138 and Asn 149
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF9 Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF9 (4-1BB/TNFRSF9/CD137)
  • Abcam antibodies for CD137

Protein Products

  • Enzo Life Sciences proteins for TNFRSF9
  • Novus Biologicals proteins for TNFRSF9
  • Cloud-Clone Corp. Proteins for TNFRSF9
  • Abcam proteins for CD137

No data available for DME Specific Peptides for TNFRSF9 Gene

Domains & Families for TNFRSF9 Gene

Gene Families for TNFRSF9 Gene

Protein Domains for TNFRSF9 Gene

Suggested Antigen Peptide Sequences for TNFRSF9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 TNFR-Cys repeats.
  • Contains 4 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF9: view

Function for TNFRSF9 Gene

Molecular function for TNFRSF9 Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 9,cell differentiation antigen CD137 (4-1BB),expressed on B and T cells,inhibiting lymphocyte proliferation,activating apoptosis
UniProtKB/Swiss-Prot Function:
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Gene Ontology (GO) - Molecular Function for TNFRSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0019955 cytokine binding IEA --
genes like me logo Genes that share ontologies with TNFRSF9: view
genes like me logo Genes that share phenotypes with TNFRSF9: view

Animal Models for TNFRSF9 Gene

MGI Knock Outs for TNFRSF9:

Animal Model Products

  • Taconic Biosciences Mouse Models for TNFRSF9

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF9 Gene

Localization for TNFRSF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF9 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TNFRSF9 Gene COMPARTMENTS Subcellular localization image for TNFRSF9 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 2
lysosome 1
nucleus 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for TNFRSF9 Gene

Pathways & Interactions for TNFRSF9 Gene

genes like me logo Genes that share pathways with TNFRSF9: view

Gene Ontology (GO) - Biological Process for TNFRSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 8639902
GO:0007275 multicellular organism development IBA --
GO:0008285 negative regulation of cell proliferation TAS 8639902
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IBA --
GO:0042127 regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with TNFRSF9: view

No data available for SIGNOR curated interactions for TNFRSF9 Gene

Drugs & Compounds for TNFRSF9 Gene

(8) Drugs for TNFRSF9 Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4-1BB ligand Pharma 0
BMS-663513 Pharma Antibody Immunomodulatory agents 0
Urelumab Pharma inhibitor 0

(1) Additional Compounds for TNFRSF9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF9: view

Transcripts for TNFRSF9 Gene

Unigene Clusters for TNFRSF9 Gene

Tumor necrosis factor receptor superfamily, member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF9 Gene

No ASD Table

Relevant External Links for TNFRSF9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF9 Gene

mRNA expression in normal human tissues for TNFRSF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF9 Gene

This gene is overexpressed in Whole Blood (x16.4) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for TNFRSF9 Gene

This gene is overexpressed in Bone (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF9 Gene

SOURCE GeneReport for Unigene cluster for TNFRSF9 Gene Hs.86447

mRNA Expression by UniProt/SwissProt for TNFRSF9 Gene

Tissue specificity: Expressed on the surface of activated T-cells.
genes like me logo Genes that share expression patterns with TNFRSF9: view

Protein tissue co-expression partners for TNFRSF9 Gene

- Elite partner

Primer Products

Orthologs for TNFRSF9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNFRSF9 35
  • 80.95 (n)
  • 74.29 (a)
  • 74 (a)
(Canis familiaris)
Mammalia TNFRSF9 35
  • 84.97 (n)
  • 78.04 (a)
  • 78 (a)
(Mus musculus)
Mammalia Tnfrsf9 35
  • 70.03 (n)
  • 59.68 (a)
Tnfrsf9 16
Tnfrsf9 36
  • 56 (a)
(Pan troglodytes)
Mammalia TNFRSF9 35
  • 99.35 (n)
  • 98.82 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tnfrsf9 35
  • 69.73 (n)
  • 60.8 (a)
(Monodelphis domestica)
Mammalia TNFRSF9 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia TNFRSF9 36
  • 47 (a)
(Gallus gallus)
Aves TNFRSF9 35
  • 51.25 (n)
  • 44.86 (a)
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfrsf9 35
  • 49.03 (n)
  • 36.41 (a)
(Danio rerio)
Actinopterygii TNFRSF9 (2 of 2) 36
  • 26 (a)
tnfrsf9a 36
  • 24 (a)
Species with no ortholog for TNFRSF9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF9 Gene

Gene Tree for TNFRSF9 (if available)
Gene Tree for TNFRSF9 (if available)

Paralogs for TNFRSF9 Gene

No data available for Paralogs for TNFRSF9 Gene

Variants for TNFRSF9 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9657963 - 7,938,763(-) CCAGC(A/G)CAGGT reference, missense
rs9657965 - 7,938,194(-) AAAAA(A/C)GGTAC reference, missense
rs9657979 - 7,935,030(-) GCCTG(A/C)CCCTG reference, missense
VAR_035478 A colorectal cancer sample
rs161803 -- 7,915,729(-) TGCTT(C/T)CAACA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF9 Gene

Variant ID Type Subtype PubMed ID
nsv871360 CNV Gain 21882294
esv2678721 CNV Deletion 23128226
esv2743452 CNV Deletion 23290073

Variation tolerance for TNFRSF9 Gene

Residual Variation Intolerance Score: 70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.67% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TNFRSF9 Gene

Disorders for TNFRSF9 Gene

MalaCards: The human disease database

(8) MalaCards diseases for TNFRSF9 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retroperitoneal hemangiopericytoma
multiple sclerosis 4
  • multiple sclerosis, susceptibility to, 4
  • madras eye
colorectal cancer
  • colorectal cancer, somatic
sciatic neuropathy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFRSF9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TNFRSF9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF9 Gene

Publications for TNFRSF9 Gene

  1. A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family. (PMID: 8262389) Schwarz H. … Lotz M. (Gene 1993) 2 3 4 67
  2. Decreased 4-1BB expression on HIV-specific CD4+ T cells is associated with sustained viral replication and reduced IL-2 production. (PMID: 19406689) Kassu A. … Palmer B.E. (Clin. Immunol. 2009) 3 23
  3. 4-1BB regulates NKG2D costimulation in human cord blood CD8+ T cells. (PMID: 18024793) Kim Y.J. … Broxmeyer H.E. (Blood 2008) 3 23
  4. Strong induction of 4-1BB, a growth and survival promoting costimulatory receptor, in HTLV-1-infected cultured and patients' T cells by the viral Tax oncoprotein. (PMID: 18276843) Pichler K. … Grassmann R. (Blood 2008) 3 23
  5. Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells. (PMID: 18645038) Hippen K.L. … Blazar B.R. (Blood 2008) 3 23

Products for TNFRSF9 Gene

Sources for TNFRSF9 Gene