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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TNFRSF9 Gene

protein-coding GIFtS: 61
GCID: GC01M007980

tumor necrosis factor receptor superfamily, member 9

(Previous symbol: ILA)

Explore 39 diseases affiliated with
TNFRSF9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 9¹ ²		T-Cell Antigen ILA² ³
CD137¹ ² ³ ⁵		Homolog Of Mouse 4-1BB²
ILA¹ ² ³ ⁵		Induced By Lymphocyte Activation (ILA)²
4-1BB¹ ²		Interleukin-Activated Receptor, Homolog Of Mouse Ly63²
4-1BB Ligand Receptor² ³		Receptor Protein 4-1BB²
CDw137² ³		T Cell Antigen ILA²
CD137 Antigen² ³		Tumor Necrosis Factor Receptor Superfamily Member 9²
T-Cell Antigen 4-1BB Homolog² ³

External Ids:	HGNC: 11924¹	Entrez Gene: 3604²	Ensembl: ENSG00000049249⁷	OMIM: 602250⁵	UniProtKB: Q07011³

Export aliases for TNFRSF9 gene to outside databases

Previous GC identifers: GC01M007561 GC01M007788 GC01M007689 GC01M007914 GC01M007902 GC01M007127

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF9:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal

expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T

cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell

responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown

to bind to this receptor and transduce the signals leading to activation of NF-kappaB. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNR9_HUMAN, Q07011

Function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation

Gene Wiki entry for TNFRSF9 (CD137)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_021937.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNFRSF9 gene promoter:
Bach2 SREBP-1c SREBP-1b c-Ets-1 FOXL1 Max POU2F1 SREBP-1a POU2F1a c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNFRSF9 promoter sequence

Search SABiosciences Chromatin IP Primers for TNFRSF9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.23 HGNC cytogenetic band: 1p36

TNFRSF9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF9 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M007980: view genomic region (about GC identifiers)

Start:	7,979,907 bp from pter	End:	8,000,926 bp from pter
Size:	21,020 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TNR9_HUMAN, Q07011 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 9 precursor

Size: 255 amino acids; 27899 Da

Subunit: Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1

Subcellular location: Membrane; Single-pass type I membrane protein

Explore the universe of human proteins at neXtProt for TNFRSF9: NX_Q07011

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q07011

TNFRSF9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001552.2

ENSEMBL proteins:

ENSP00000366729 ENSP00000465272 ENSP00000464978

Human Recombinant Protein Products for TNFRSF9:

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	Sino Biological Recombinant Protein for TNFRSF9
	ProSpec Recombinant Protein for TNFRSF9
	Uscn Proteins for TNFRSF9

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	8262389
GO:0009897	external side of plasma membrane	IEA	--

TNFRSF9 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TNFRSF9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNFRSF9 for domains About GeneDecksing

2 InterPro domains/families:

IPR001368 TNFR/NGFR_Cys_rich_reg

IPR020413 TNFR_9

Graphical View of Domain Structure for InterPro Entry Q07011

ProtoNet protein and cluster: Q07011

1 Blocks protein family: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNR9_HUMAN, Q07011

Similarity: Contains 4 TNFR-Cys repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TNR9_HUMAN, Q07011

Function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation

Genatlas biochemistry entry for TNFRSF9:

tumor necrosis factor receptor superfamily,member 9,cell differentiation antigen CD137 (4-1BB),expressed on B and T

cells,inhibiting lymphocyte proliferation,activating apoptosis

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--

TNFRSF9 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for TNFRSF9:

Synthetic lethal with c-Myc af

Synthetic lethal with imatinib

11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tnfrsf9):

cellular	craniofacial	endocrine/exocrine gland	hearing/vestibular/ear	hematopoietic system
immune system	integument	mortality/aging	no phenotypic analysis	renal/urinary system
vision/eye

TNFRSF9 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Tnfrsf9^tm1Byk for TNFRSF9

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TNFRSF9

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFRSF9
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFRSF9 (see all 9):
		hsa-miR-579 hsa-miR-1290 hsa-miR-3688-3p hsa-miR-759 hsa-miR-4261 hsa-miR-141* hsa-miR-494 hsa-miR-1914

		SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF9 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF9 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF9

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

PEDF Induced Signaling

STAT3 Pathway

0.47

Cytokine-cytokine receptor interaction

0.26

TRAF Pathway

TNF Superfamily Pathway

0.42

TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

0.08

4-1BB Pathway

4-1BB Pathway

1.00

Downstream signaling in naive CD8+ T cells

Downstream signaling in naive CD8+ T cells

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for TNFRSF9

TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF9 (see all 8)

	STAT3 Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Tec Kinases Signaling
	4-1BB Pathway

2 BioSystems Pathways for TNFRSF9

	TCR Signaling Pathway
	Downstream signaling in naive CD8+ T cells

1 Kegg Pathway (Kegg details for TNFRSF9):

Cytokine-cytokine receptor interaction

TNFRSF9 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TNFRSF9

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/12 Interacting proteins for TNFRSF9 (Q07011³ ENSP00000366729⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TNFRSF4	P43489³, ENSP00000368538⁴	I2D: score=3 STRING: ENSP00000368538
TRAF2	Q12933³, ENSP00000247668⁴	I2D: score=5 STRING: ENSP00000247668
TNFSF9	P41273³, ENSP00000245817⁴	I2D: score=2 STRING: ENSP00000245817
TRAF1	Q13077³, ENSP00000362994⁴	I2D: score=5 STRING: ENSP00000362994
TRAF3	Q13114³, ENSP00000332468⁴	I2D: score=5 STRING: ENSP00000332468

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006917	induction of apoptosis	TAS	8639902
GO:0008285	negative regulation of cell proliferation	TAS	8639902
GO:0042127	regulation of cell proliferation	--	--

TNFRSF9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TNFRSF9 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNFRSF9
6 Novoseek chemical compound relationships for TNFRSF9 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ccl3	39.1	1	15470070 (1)
ionomycin	33.2	1	12706838 (1)
calcium	4.13	3	16488622 (2), 16123219 (1)
tyrosine	0	1	8335927 (1)
cysteine	0	1	16204238 (1)
dexamethasone	0	1	9536288 (1)

Search CenterWatch for drugs/clinical trials and news about TNFRSF9 / TNR9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNFRSF9 gene:

NM_001561.5

Unigene Cluster for TNFRSF9:

Tumor necrosis factor receptor superfamily, member 9

Hs.86447 [show with all ESTs]

Unigene Representative Sequence: NM_001561

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000377507(uc001aot.3) ENST00000474475 ENST00000492571

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFRSF9
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFRSF9 (see all 9):
		hsa-miR-579 hsa-miR-1290 hsa-miR-3688-3p hsa-miR-759 hsa-miR-4261 hsa-miR-141* hsa-miR-494 hsa-miR-1914

		SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF9 3' UTR sequence

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Additional cDNA sequence:

AK125490.1 BC006196.2 L12964.2 U03397.1

3 DOTS entries:

DT.104964 DT.40117698 DT.92050016

24/28 AceView cDNA sequences (see all 28):

BF056988 AA210970 AI583069 NM_001561 BC006196 AW449076 CA308737 AI990212

BX283080 L12964 BU626483 BE207340 BG436824 BP382461 BP381234 BF064069

AK125490 CD641590 BF509155 CD521747 CD640203 BG058770 AA211393 CD700025

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNFRSF9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTGCCAGG

About this image

TNFRSF9 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TNFRSF9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFRSF9

SOURCE GeneReport for Unigene cluster: Hs.86447

UniProtKB/Swiss-Prot: TNR9_HUMAN, Q07011

Tissue specificity: Expressed on the surface of activated T-cells

SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF9 (see all 6):

Th1/Th2 Response in human mouse rat

TNF Ligands & Receptors in human mouse rat

T Helper Cell Differentiation in human mouse rat

Apoptosis 384HT in human mouse rat

Apoptosis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF9

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF9 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Tnfrsf9^{1 , 5}	tumor necrosis factor receptor superfamily, member more^{1, 5}	70.03(n)¹ 59.68(a)¹	4 (81.52 cM)⁵ 21942¹ NM_001077509.1¹ NP_001070977.1¹ 150914562⁵
chicken (Gallus gallus)	Aves	TNFRSF9¹	tumor necrosis factor receptor superfamily, member more	51.09(n) 43.46(a)	419365 XM_417526.3 XP_417526.3
zebrafish (Danio rerio)	Actinopterygii	tnfrsf9a¹	tumor necrosis factor receptor superfamily, member more	44.59(n) 34.42(a)	678622 NM_001040369.1 NP_001035459.1

ENSEMBL Gene Tree for TNFRSF9 (if available)
TreeFam Gene Tree for TNFRSF9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TNFRSF9 gene

TNFRSF21² TNFRSF6B² CD40² TNFRSF1B² TNFRSF4² TNFRSF11A² NGFR² TNFRSF14²

TNFRSF11B² LTBR²

TNFRSF9 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138514264^1,2		--	7975476(+)	`AGAGTA/CTCGCT`	1	--	ds500¹		0	--	--	--	--
rs141961368^1,2		--	7975551(+)	`CAAGTC/GATTTT`	1	--	ds500¹		0	--	--	--	--
rs161805^1,2	C,F,A,H	--	7975595(-)	`TGGCAT/CGCACC`	1	--	ds500¹		3		NA	10
rs161804^1,2	C,F,H	--	7975638(-)	`AACCCC/TGCCTC`	1	--	ds500¹		8		NA WA CSA	18
rs76772299^1,2	F	--	7975783(+)	`GTCAAT/CTGTTG`	1	--	ds500¹		1		EA	120
rs161803^1,2	C,F,A,H	--	7975789(-)	`TGCTTT/CCAACA`	1	--	ds500¹		24		NS EA NA WA CSA	2686
rs149281037^1,2		--	7975826(+)	`AGCATA/CCTTCG`	1	--	ds500¹		0	--	--	--	--
rs193218024^1,2		--	7975926(+)	`TAAAAA/TAAGGT`	1	--	ds500¹		0	--	--	--	--
rs12403741^1,2	H	--	7975931(+)	`TAAGGG/TCTTTT`	1	--	ut3¹		0	--	--	--	--
rs184733969^1,2		--	7976006(+)	`AAAACA/GTTGAT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TNFRSF9 (7979907 - 8000926 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TNFRSF9: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFRSF9

DNA2.0 Custom Variant and Variant Library Synthesis for TNFRSF9

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TNFRSF9 for disorders           About GeneDecksing

OMIM gene information: 602250    OMIM disorders: --

20/39 diseases for TNFRSF9 (see all 39):    About MalaCards

graft versus host disease human monocytic ehrlichiosis icos deficiency severe combined immunodeficiency

wegener's granulomatosis typhoid fever combined immunodeficiency b-cell lymphomas

allergic conjunctivitis autoimmune myocarditis graves' disease bronchogenic carcinoma

goiter acute lymphoblastic leukemia ehrlichiosis rheumatoid arthritis

lymphoblastic leukemia respiratory failure myocarditis conjunctivitis

10/15 Novoseek disease relationships for TNFRSF9 gene (see all 15) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	59.6	59	9045669 (3), 9464265 (2), 18668547 (2), 16123219 (2) (see all 37)
tumors	46.4	85	14716821 (4), 17990986 (3), 19773745 (3), 9045669 (3) (see all 45)
goiter nodular	40	1	16459462 (1)
graft-versus-host disease	34	3	11207270 (2)
rheumatoid arthritis	27	3	18668547 (1), 15031666 (1)
autoimmune diseases	25.6	5	16002686 (1), 16443548 (1), 12695569 (1)
asthma allergic	13.1	1	11447378 (1)
graves disease	7.56	2	16232366 (1), 16459462 (1)
inflammation	3.06	3	19233196 (1), 19104082 (1)
solid tumor	2.82	2	10946324 (1)

Human Genome Epidemiology (HuGE) Navigator: TNFRSF9 (9 documents)

Export disorders for TNFRSF9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TNFRSF9 gene, integrated from 9 sources (see all 206):
(articles sorted by number of sources associating them with TNFRSF9)

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A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family. (PubMed id 8262389)^{1, 2, 3} Schwarz H.... Lotz M. (1993)
Molecular and biological characterization of human 4-1BB and its ligand. (PubMed id 8088337)^{1, 2, 9} Alderson M.R.... Goodwin R.G. (1994)
Characterization of human homologue of 4-1BB and its ligand. (PubMed id 7622190)^{1, 2, 9} Zhou Z....Kwon B.S. (1995)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A novel leucine-rich repeat protein (LRR-1): potential involvement in 4-1BB-mediated signal transduction. (PubMed id 11804328)^{1, 2} Jang I.-K.... Kwon B.S. (2001)
4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. (PubMed id 9418902)^{1, 2} Arch R.H. and Thompson C.B. (1998)
CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand. (PubMed id 9607925)^{1, 2} Saoulli K....Watts T.H. (1998)
ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survi val. (PubMed id 8639902)^{1, 3} Schwarz H....Lotz M. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3604	HGNC: 11924	AceView: TNFRSF9	Ensembl:ENSG00000049249	euGenes: HUgn3604
ECgene: TNFRSF9	Kegg: 3604	H-InvDB: TNFRSF9

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TNFRSF9	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFRSF9	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/tnfrsf9/

Intellectual Property for TNFRSF9 gene
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Patent Information for TNFRSF9 gene:
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tumor necrosis factor receptor superfamily, member 9

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TNFRSF9 Gene

tumor necrosis factor receptor superfamily, member 9

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