TNFRSF8 Gene
protein-coding GIFtS : 65
GCID: GC01 P012123
tumor necrosis factor receptor superfamily, member 8 (Previous symbols: CD30, D1S166E )
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Aliasesfor TNFRSF8 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Tumor Necrosis Factor Receptor Superfamily, Member 8 1 2 KI-11 CD301 2 3 5 Ki-12 D1S166E1 2 3 5 Cytokine Receptor CD302 Lymphocyte Activation Antigen CD302 3 Tumor Necrosis Factor Receptor Superfamily Member 82 CD30L Receptor2 3 CD30 Antigen3 Ki-1 Antigen2 3
Export aliases for TNFRSF8 gene to outside databases Previous GC identifers: GC01P012187 GC01P011968 GC01P011732 GC01P011832 GC01P012057 GC01P011277
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Summariesfor TNFRSF8 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for TNFRSF8 : The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908 Function : Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation ofactivated lymphoblasts. Regulates gene expression through activation of NF-kappa-B Gene Wiki entry for TNFRSF8 (CD30)
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Genomic Viewsfor TNFRSF8 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_021937.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TNFRSF8 gene promoter: STAT5B p53 STAT1beta STAT5A NF-E2 p45 STAT1alpha STAT2 STAT3 NF-E2 RSRFC4 Other transcription factors Search SABiosciences Chromatin IP Primers for TNFRSF8 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TNFRSF8
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36 TNFRSF8 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P012123: view genomic region
(about GC identifiers )
Start:
12,123,434 bp from pter
End:
12,204,264 bp from pter
Size:
80,831 bases
Orientation:
plus strand
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Proteinsfor TNFRSF8 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908 (See
protein sequence )Recommended Name: Tumor necrosis factor receptor superfamily member 8 precursor Size : 595 amino acids; 63747 Da
Subunit : Interacts with TRAF1, TRAF2, TRAF3 and TRAF5
Subcellular location : Isoform Long: Cell membrane; Single-pass type I membrane protein
Subcellular location : Isoform Short: Cytoplasm
Miscellaneous : Most specific Hodgkin disease associated antigen
1 PDB 3D structure from and Proteopedia for TNFRSF8 :1D01 (3D)
 
Secondary accessions : B1AN79 Q6P4D9Alternative initiation : 2 isoforms : P28908-1 P28908-2 Explore the universe of human proteins at neXtProt for TNFRSF8: NX_P28908 Post-translational modifications:
Phosphorylated on serine and tyrosine residues1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P28908 TNFRSF8 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts):
NP_001234.2 NP_694421.1 ENSEMBL proteins: ENSP00000263932 ENSP00000421938 ENSP00000398337 ENSP00000390650 Human Recombinant Protein Products for TNFRSF8: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
TNFRSF8 for ontologies About GeneDecksing TNFRSF8 Antibody Products: Assay Products for TNFRSF8:
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Protein
Domains / Familiesfor TNFRSF8 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TNFRSF8 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P28908 ProtoNet protein and cluster: P28908
1 Blocks protein family : IPB001368 TNFR/CD27/30/40/95 cysteine-rich region UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908 Similarity : Contains 6 TNFR-Cys repeats
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Functionfor TNFRSF8 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: TNR8_HUMAN, P28908 Function : Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation ofactivated lymphoblasts. Regulates gene expression through activation of NF-kappa-B
Genatlas biochemistry entry for TNFRSF8 : tumor necrosis factor receptor superfamily,member 8,cell differentiation antigen CD30 (Ki-1),lymphoid activating,identified by monoclonal antibodies HRS-1,Ki-1 Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
TNFRSF8 for ontologies About GeneDecksing Phenotypes: 2 GenomeRNAi human phenotypes for TNFRSF8 : 3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tnfrsf8) :
TNFRSF8 for phenotypes About GeneDecksing Animal Models: Mouse knock-out Tnfrsf8 tm1Mak for TNFRSF8Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TNFRSF8 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TNFRSF8 (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): TNFRSF8 (NM_001243 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNFRSF8 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TNFRSF8
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF8
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Pathways & Interactionsfor TNFRSF8 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/7 super-pathways (see all 7 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Akt Signaling 2 Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 3 PEDF Induced Signaling 4 TRAF Pathway 5 TNF-alpha/NF-kB Signaling Pathway
Pathway sources See GeneCards unified pathways Show all pathways 1 EMD Millipore Pathway for TNFRSF8 1 R&D Systems Pathway for TNFRSF8 5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF8 (see all 7 )1 GeneGo (Thomson Reuters) Pathway for TNFRSF8 1 BioSystems Pathway for TNFRSF8 1
Kegg Pathway (Kegg details for TNFRSF8) :
TNFRSF8 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF8 STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)5/9 Interacting proteins for TNFRSF8 (P28908 3 ENSP00000263932 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 9 )About this table Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8 ): About this table
TNFRSF8 for ontologies About GeneDecksing
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Drugs & Compoundsfor TNFRSF8 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
TNFRSF8 for compounds About GeneDecksing Browse Tocris compounds for TNFRSF8 10/14 Novoseek chemical compound relationships for TNFRSF8 gene (see all 14 ) About this table
1 PharmGKB related drug/compound annotation for TNFRSF8 gene About this table Search CenterWatch for drugs/clinical trials and news about TNFRSF8 / TNR8
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Transcriptsfor TNFRSF8 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TNFRSF8 gene (2 alternative transcripts): NM_001243.3 NM_152942.2 Unigene Cluster for TNFRSF8:
Tumor necrosis factor receptor superfamily, member 8 Hs.1314 [show with all ESTs ] Unigene Representative Sequence: NM_001243 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000263932 (uc001atq.3 uc010obc.2 ) ENST00000514649 ENST00000413146 (uc001atr.3 uc001ats.3 )ENST00000479933 ENST00000417814 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TNFRSF8 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TNFRSF8 (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): TNFRSF8 (NM_001243 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNFRSF8 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TNFRSF8
Additional cDNA sequence: BC063482.1 BC073839.1 BC136400.1 BC141804.1 BC171762.1 D86042.1 M83554.1 S75768.1
3 DOTS entries : DT.310731 DT.91720897
DT.95153621 22 AceView cDNA sequences :
NM_152942 NM_001243 BC073839 BX110183 BC063482 BF591056 AA047161 BE877671 AA310772 BV199006 M83554 D86042 BU927609 BI909097 AA147594 AI203419 BI908989 AI699969 BP430908 AA928635 BG495230 AA047162 GeneLoc Exon Structure
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Expression for TNFRSF8 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TNFRSF8 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTTCAACAAAAbout this image TNFRSF8 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
Stem Cell Differentiation: 1 LifeMap Cell Name Category Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TNFRSF8 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TNFRSF8 SOURCE GeneReport for Unigene cluster: Hs.1314 SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF8 (see all 8 ): Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TNFRSF8Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TNFRSF8 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TNFRSF8 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TNFRSF8 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF8
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Orthologsfor TNFRSF8 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for TNFRSF8 gene from 2/6 species (see all 6 ) About this table
ENSEMBL Gene Tree for TNFRSF8 (if available)TreeFam Gene Tree for TNFRSF8 (if available)
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Paralogsfor TNFRSF8 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor TNFRSF8 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More