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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF8 Gene

protein-coding   GIFtS: 66
GCID: GC01P012123

Tumor Necrosis Factor Receptor Superfamily, Member 8


(Previous symbols: CD30, D1S166E)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 81 2     Ki-1 Antigen2 3
CD301 2 3 5     Ki-12
D1S166E1 2 3 5     Cytokine Receptor CD302
Lymphocyte Activation Antigen CD302 3     Tumor Necrosis Factor Receptor Superfamily Member 82
CD30L Receptor2 3     CD30 Antigen3

External Ids:    HGNC: 119231   Entrez Gene: 9432   Ensembl: ENSG000001209497   OMIM: 1532435   UniProtKB: P289083   

Export aliases for TNFRSF8 gene to outside databases

Previous GC identifers: GC01P012187 GC01P011968 GC01P011732 GC01P011832 GC01P012057 GC01P011277


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF8 Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by
activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the
signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of
apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and
protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding
distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFRSF8 Gene: 
TNFRSF8 (tumor necrosis factor receptor superfamily, member 8) is a protein-coding gene. Diseases associated with TNFRSF8 include splenic abscess, and pityriasis lichenoides et varioliformis acuta, and among its related super-pathways are TNF Signaling and STAT3 Pathway. GO annotations related to this gene include transmembrane signaling receptor activity and tumor necrosis factor-activated receptor activity.

UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908
Function: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of
activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B

Gene Wiki entry for TNFRSF8 (CD30) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF8 gene promoter:
         STAT5B   p53   STAT1beta   STAT5A   NF-E2 p45   STAT1alpha   STAT2   STAT3   NF-E2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF8 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36

TNFRSF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P012123:  view genomic region     (about GC identifiers)

Start:
12,123,434 bp from pter      End:
12,204,264 bp from pter
Size:
80,831 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 8 precursor  
Size: 595 amino acids; 63747 Da
Subunit: Interacts with TRAF1, TRAF2, TRAF3 and TRAF5
Subcellular location: Isoform Long: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform Short: Cytoplasm
Miscellaneous: Most specific Hodgkin disease associated antigen
1 PDB 3D structure from and Proteopedia for TNFRSF8:
1D01 (3D)    
Secondary accessions: B1AN79 Q6P4D9
Alternative initiation: 2 isoforms:  P28908-1   P28908-2   

Explore the universe of human proteins at neXtProt for TNFRSF8: NX_P28908

Explore proteomics data for TNFRSF8 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on serine and tyrosine residues
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P28908

  • TNFRSF8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNFRSF8 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001234.2  NP_001268359.1  

    ENSEMBL proteins: 
     ENSP00000263932   ENSP00000421938   ENSP00000398337   ENSP00000390650  

    Human Recombinant Protein Products for TNFRSF8: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TNFRSF8
    OriGene Custom MassSpec 
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    Sino Biological Recombinant Protein for TNFRSF8
    Sino Biological Cell Lysate for TNFRSF8 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNFRSF8 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    TNFRSF8 for ontologies           About GeneDecksing



    TNFRSF8 Antibody Products: 
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    Abcam antibodies for TNFRSF8
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    ThermoFisher Antibody for TNFRSF8
    LSBio Antibodies in human, mouse, rat for TNFRSF8 

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    Cloud-Clone Corp. ELISAs for TNFRSF8 
    Cloud-Clone Corp. CLIAs for TNFRSF8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: CD30 
    Tumour necrosis factor (TNF) receptor family

    2 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR020416 TNFR_8

    Graphical View of Domain Structure for InterPro Entry P28908

    ProtoNet protein and cluster: P28908

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908
    Similarity: Contains 6 TNFR-Cys repeats


    TNFRSF8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR8_HUMAN, P28908
    Function: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of
    activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B

         Genatlas biochemistry entry for TNFRSF8:
    tumor necrosis factor receptor superfamily,member 8,cell differentiation antigen CD30 (Ki-1),lymphoid
    activating,identified by monoclonal antibodies HRS-1,Ki-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS1310894
    GO:0005031tumor necrosis factor-activated receptor activity RCA19641626
    GO:0005515protein binding ----
         
    TNFRSF8 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNFRSF8:
     Decreased Hepatitis C virus re  Increased HPV18 LCR reporter a 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tnfrsf8):
     hematopoietic system  immune system 

    TNFRSF8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tnfrsf8tm1Mak for TNFRSF8

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNFRSF8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNFRSF8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF8 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF8 3' UTR sequence
    Inhib. RNA
    Products:
        
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                         Customized lentivirus expression plasmids for stable overexpression of TNFRSF8 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNFRSF8 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    5Rho Family GTPases
    Molecular Mechanisms of Cancer0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TNFRSF8
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

    1 R&D Systems Pathway for TNFRSF8
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF8 (see all 7)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling

    1 GeneGo (Thomson Reuters) Pathway for TNFRSF8
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

    1 BioSystems Pathway for TNFRSF8
        TNF-alpha/NF-kB Signaling Pathway

    3 Sino Biological Pathways for TNFRSF8 
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1         Kegg Pathway  (Kegg details for TNFRSF8):
        Cytokine-cytokine receptor interaction


    TNFRSF8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for TNFRSF8 (P289083 ENSP000002639324) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF5O004633, ENSP000002614644I2D: score=4 STRING: ENSP00000261464
    TDP2O955513, ENSP000003674404I2D: score=3 STRING: ENSP00000367440
    TNFSF8P329713, ENSP000002237954I2D: score=2 STRING: ENSP00000223795
    ALKQ9UM733, ENSP000003737004I2D: score=1 STRING: ENSP00000373700
    TRAF2Q129333, ENSP000002476684I2D: score=4 STRING: ENSP00000247668
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS10192335
    GO:0008285negative regulation of cell proliferation TAS10192335
    GO:0033209tumor necrosis factor-mediated signaling pathway RCA19641626
    GO:0042535positive regulation of tumor necrosis factor biosynthetic process IDA16108830
    GO:0043065positive regulation of apoptotic process IDA16108830

    TNFRSF8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNFRSF8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFRSF8 (TNR8)

    1 IUPHAR Ligand for TNFRSF8 (CD30)    About this table 
    LigandTypeActionAffinityPubmed IDs
    CD30 ligand
    NoneNone--

    10/14 Novoseek inferred chemical compound relationships for TNFRSF8 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    [alcl] 88.6 33 17965727 (5), 16140928 (3), 12754742 (2), 8055109 (1) (see all 15)
    saporin 55 2 7517259 (1), 8903477 (1)
    paraffin 49.7 7 7745117 (2), 8912826 (1), 11866962 (1), 12475440 (1) (see all 6)
    ricin a 35.2 1 2152774 (1)
    ricin 16.1 1 7591211 (1)
    calcium 1.64 5 7866279 (1), 7527901 (1), 7869589 (1)
    lipid 1.03 5 15034047 (3)
    thymidine 0 1 8535215 (1)
    tuberculin 0 1 8568238 (1)
    threonine 0 1 16879614 (1)

    1 PharmGKB related drug/compound annotation for TNFRSF8 gene    About this table
    Drug/compound PharmGKB Annotation
    brentuximab vedotin

    Search CenterWatch for drugs/clinical trials and news about TNFRSF8 / TNR8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNFRSF8 gene (3 alternative transcripts): 
    NM_001243.3  NM_001281430.1  NM_152942.2  

    Unigene Cluster for TNFRSF8:

    Tumor necrosis factor receptor superfamily, member 8
    Hs.1314  [show with all ESTs]
    Unigene Representative Sequence: NM_001243
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263932(uc001atq.3 uc010obc.2) ENST00000514649 ENST00000413146(uc001atr.3 uc001ats.3)
    ENST00000479933 ENST00000417814

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    Additional mRNA sequence: 

    BC063482.1 BC073839.1 BC136400.1 BC141804.1 BC171762.1 D86042.1 M83554.1 S75768.1 

    3 DOTS entries:

    DT.310731  DT.91720897  DT.95153621 

    22 AceView cDNA sequences:

    BC073839 NM_152942 BF591056 NM_001243 AA047161 BC063482 BX110183 D86042 
    AA310772 M83554 BV199006 BE877671 BU927609 AA147594 BI909097 BI908989 
    BP430908 AI203419 AI699969 AA928635 BG495230 AA047162 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFRSF8 expression in normal human tissues (normalized intensities)      TNFRSF8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAACAAA
    TNFRSF8 Expression
    About this image


    TNFRSF8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Colon (Gastrointestinal Tract)
             colon ; endothelial cells   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Lower Urinary Tract (Urinary System)
             urinary bladder ; urothelial cells   
     
     Oral Cavity (Gastrointestinal Tract)
             oral mucosa ; squamous epithelial cells   
     
     Pancreas (Endocrine System)
             pancreas ; exocrine glandular cells   

    See TNFRSF8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFRSF8

    SOURCE GeneReport for Unigene cluster: Hs.1314
        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF8 (see all 8): 
              Cell Surface Markers in human mouse rat
              Th1/Th2 Response in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF8 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf81 , 5 tumor necrosis factor receptor superfamily, member more1, 5 63.8(n)1
    52.76(a)1
      4 (78.17 cM)5
    219411  NM_009401.21  NP_033427.11 
     1452671375 
    chicken
    (Gallus gallus)
    Aves TNFRSF81 tumor necrosis factor receptor superfamily, member more 49.38(n)
    38.11(a)
      395090  NM_204444.1  NP_989775.1 


    ENSEMBL Gene Tree for TNFRSF8 (if available)
    TreeFam Gene Tree for TNFRSF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2005 SNPs in TNFRSF8 are shown (see all 2005)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0187534
    ----see VAR_0187532 C Y mis40--------
    rs1136626681,2
    C--12122309(+) CTGCTCATC/-  
            
    CATCC
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs97020051,2
    A--12122332(+) atccaC/Tctatg 1 -- us2k10--------
    rs1424441371,2
    C--12127960(+) GGGGC-/GGGGGG 1 -- int10--------
    rs352493511,2
    C--12130203(+) GGGGG-/GCTGGG 1 -- int10--------
    rs612066851,2
    C--12130219(+) TTGGG-/GGGAGCAG 1 -- int10--------
    rs57724831,2
    C--12137926(+) TTTGGT/-TTTTT 1 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs1453942731,2
    --12139785(+) ACCTCA/GGCCTC 1 -- us2k10--------
    rs760118091,2
    F--12139822(+) GCCATA/GTCACC 1 -- us2k10--------
    rs1167833061,2
    C,F--12139888(+) TCTTGC/TGTTCC 1 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for TNFRSF8 (12123434 - 12204264 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TNFRSF8:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662914CNV Deletion23128226
    esv1290308CNV Deletion17803354
    esv2670946CNV Deletion23128226
    esv2743796CNV Deletion23290073
    nsv508891CNV Insertion20534489
    nsv466060CNV Loss19166990
    nsv820293CNV Loss19587683
    nsv525898CNV Loss19592680
    nsv469830CNV Complex16826518

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFRSF8
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFRSF8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 153243    OMIM disorders: --

    20/100 diseases for TNFRSF8 (see all 100):    About MalaCards
    splenic abscess    pityriasis lichenoides et varioliformis acuta    interdigitating dendritic cell sarcoma    pityriasis lichenoides
    composite lymphoma    marek disease    intravascular large b-cell lymphoma    lymphoepithelioma-like carcinoma
    lymphosarcoma    anaplastic large cell lymphoma    lymphomatoid papulosis    mast-cell leukemia
    reticulosarcoma    hodgkin's lymphoma    panniculitis    malignant histiocytosis
    cutaneous leishmaniasis    mycosis fungoides    dendritic cell sarcoma    histiocytosis

    3 diseases from the University of Copenhagen DISEASES database for TNFRSF8:
    Reticulosarcoma     Lymphoma     Malignant histiocytosis

    TNFRSF8 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/75 Novoseek inferred disease relationships for TNFRSF8 gene (see all 75)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anaplastic large cell lymphoma 95.2 70 8183550 (4), 8960041 (2), 12754742 (2), 17965727 (2) (see all 55)
    hodgkin disease 87.9 79 11004694 (2), 12754742 (2), 12875982 (2), 9209650 (2) (see all 67)
    lymphomatoid papulosis 87.3 14 11121138 (2), 15894695 (2), 1344811 (1), 10556192 (1) (see all 7)
    lymphoma large cell 84.2 20 11729213 (2), 1335094 (1), 11891807 (1), 8390600 (1) (see all 15)
    lymphoma 79.9 72 11594583 (3), 1330287 (3), 19131793 (2), 10628334 (2) (see all 52)
    lymphoma pleomorphic 79.2 1 10672058 (1)
    lymphoma t-cell peripheral 74 4 7982672 (1), 1652981 (1), 8513200 (1), 12645345 (1)
    lymphoma non-hodgkins 71.9 23 8055109 (2), 7982672 (1), 7564510 (1), 10793083 (1) (see all 22)
    lymphoma t-cell 71.5 14 1659246 (1), 12692428 (1), 1509528 (1), 15328201 (1) (see all 13)
    lymphoproliferative disorders 69.9 7 15894695 (3), 10793083 (1), 17320171 (1), 16882190 (1) (see all 5)

    Genetic Association Database (GAD): TNFRSF8
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF8 (10 documents)

    Export disorders for TNFRSF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFRSF8 gene, integrated from 9 sources (see all 463) (see top 10):
    (articles sorted by number of sources associating them with TNFRSF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease. (PubMed id 1310894)1, 2, 3 Duerkop H.... Stein H. (1992)
    2. Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the CD30 antigen from different sources. (PubMed id 7527901)1, 2, 9 Jung W....Pfreundschuh M. (1994)
    3. Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population. (PubMed id 11960307)1, 4, 9 Ahmed S....Hara T. (2002)
    4. Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). (PubMed id 9511754)1, 2, 9 Mizushima S.... Inoue J. (1998)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    7. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    8. Prognostic values of soluble CD30 and CD30 gene polymorphisms in heart transplantation. (PubMed id 16641601)1, 4 Frisaldi E....Amoroso A. (2006)
    9. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PubMed id 15301860)1, 4 Cho S.M....Lee J.K. (2004)
    10. Distribution of human CD30 gene promoter microsatellite alleles in healthy and human immunodeficiency virus-1 infected populations. (PubMed id 12648280)1, 4 McIntyre M.Q....Abraham L.J. (2003)
    11. Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily. (PubMed id 9168896)1, 2 Boucher L.-M.... Mak T.W. (1997)
    12. Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. (PubMed id 8999898)1, 2 Aizawa S.... Watanabe T. (1997)
    13. T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors. (PubMed id 8627180)1, 2 Lee S.Y.... Choi Y. (1996)
    14. A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophages. (PubMed id 8839832)1, 2 Horie R.... Watanabe T. (1996)
    15. Assignment of the human CD30 (Ki-1) gene to 1p36. (PubMed id 1330892)1, 3 Fonatsch C....Stein H. (1992)
    16. Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma. (PubMed id 17965727)1, 9 Watanabe M....Horie R. (2008)
    17. Marek's disease is a natural model for lymphomas overexpressing Hodgkin's disease antigen (CD30). (PubMed id 15356338)1, 9 Burgess S.C....Davison T.F. (2004)
    18. CD30 expression utilization for the accuracy of classical Hodgkin's lymphoma staging. (PubMed id 17106517)1, 9 Flangea C....Dogaru C. (2006)
    19. AP-1 mediated relief of repressive activity of the CD30 promoter microsatellite in Hodgkin and Reed-Sternberg cells. (PubMed id 12875982)1, 9 Watanabe M....Horie R. (2003)
    20. CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins. (PubMed id 8662842)1, 9 Gedrich R.W....Thompson C.B. (1996)
    21. Human embryonal epithelial cells of the developing small intestinal crypts can express the Hodgkin-cell associated antigen Ki-1 (CD30) in spontaneous abortions during the first trimester of gestation. (PubMed id 15644135)1, 9 Tamiolakis D....Papadopoulos N. (2005)
    22. Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cells. (PubMed id 11971184)1, 9 Horie R....Watanabe T. (2002)
    23. Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3. (PubMed id 8183550)1, 9 Shiota M....Mori S. (1994)
    24. Altered expression of the lymphocyte activation antig en CD30 in active celiac disease. (PubMed id 20166880)1, 9 Periolo N....CherA+avsky A.C. (2010)
    25. CD30 expression identifies the predominant proliferating T lymphocyte population in human alloimmune responses. (PubMed id 12165500)1, 9 Chan K.W....Martinez O.M. (2002)
    26. The tyrosine kinase NPM-ALK, associated with anaplastic large cell lymphoma, binds the intracellular domain of the surface receptor CD30 but is not activated by CD30 stimulation. (PubMed id 10641597)1, 9 Hubinger G....Bergmann L. (1999)
    27. TRAF1 is involved in the classical NF-kappaB activati on and CD30-induced alternative activity in Hodgkin's lymphoma cells. (PubMed id 19540595)1, 9 Guo F....Chen Z. (2009)
    28. Pathophysiological functions of CD30+ CD4+ T cells in rheumatoid arthritis. (PubMed id 14726963)1, 9 Okamoto A....Makino H. (2003)
    29. Ber-H2 (CD30) immunohistochemical staining of human fetal tissues. (PubMed id 16244703)1, 9 Tamiolakis D....Kouskoukis C. (2005)
    30. CD30 and the NPM-ALK fusion protein (p80) are differentially expressed between peripheral blood and bone marrow in primary small cell variant of anaplastic large cell lymphoma. (PubMed id 11891807)1, 9 Awaya N....Abe T. (2002)
    31. Co-expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) in thyroid nodules is associated with co-expression of CD30 ligand/CD30 receptor. (PubMed id 12553555)1, 9 Ruggeri R.M....Benvenga S. (2002)
    32. CD30L up-regulates CD30 and IL-4 expression by T cells. (PubMed id 11728464)1, 9 Rossi F.M....Gattei V. (2001)
    33. Two distinct signalling cascades target the NF-kappaB regulatory factor c-IAP1 for degradation. (PubMed id 19243308)1, 9 Csomos R.A....Duckett C.S. (2009)
    34. Selective redox regulation of cytokine receptor signaling by extracellular thioredoxin-1. (PubMed id 17557078)1, 9 Schwertassek U....Dick T.P. (2007)
    35. CD30-induced up-regulation of the inhibitor of apoptosis genes cIAP1 and cIAP2 in anaplastic large cell lymphoma cells. (PubMed id 15050749)1, 9 Hubinger G....Muller E. (2004)
    36. Signal transduction in anaplastic large cell lymphoma cells (ALCL) mediated by the tumor necrosis factor receptor CD30. (PubMed id 15291361)1, 9 Schneider C....Hubinger G. (2004)
    37. Hodgkin's lymphoma and CD30 signal transduction. (PubMed id 12568298)1, 9 Horie R....Watanabe T. (2003)
    38. TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation. (PubMed id 10764746)1, 9 Pype S.... Remacle J.E. (2000)
    39. Release of soluble CD30 after allogeneic stimulation i s mediated by memory T cells and regulated by IFN-g and IL-2. (PubMed id 23857000)1 Velasquez S.Y....Susal C. (2013)
    40. RIP1 expression is necessary for CD30-mediated cell de ath induction in anaplastic large-cell lymphoma cells. (PubMed id 23545938)1 Hirsch B....Durkop H. (2013)
    41. Soluble CD26 and CD30 levels in patients with common v ariable immunodeficiency. (PubMed id 23654079)1 Mahmoudi M....Rezaei N. (2013)
    42. CD30 expression in acute myeloid leukemia is associate d with FLT3-internal tandem duplication mutation and leukocytosis. (PubMed id 22966913)1 Fathi A.T....Hasserjian R.P. (2013)
    43. CD30 expression defines a novel subgroup of diffuse la rge B-cell lymphoma with favorable prognosis and distinct gene expression signat ure: a report from the International DLBCL Rituximab-CHOP Consortium Program Stu dy. (PubMed id 23343832)1 Hu S....Young K.H. (2013)
    44. Post-transplant monitoring of soluble CD30 level as pr edictor of graft outcome: a single center experience from China. (PubMed id 23079227)1 Wang D....Tan J. (2012)
    45. Alloantigen-stimulated induction and release of CD30 i n patients with end-stage renal failure. (PubMed id 22940451)1 Velasquez S.Y....Alvarez C.M. (2012)
    46. Pityriasis lichenoides et varioliformis acuta with num erous CD30(+) cells: a variant mimicking lymphomatoid papulosis and other cutane ous lymphomas. A clinicopathologic, immunohistochemical, and molecular biologica l study of 13 cases. (PubMed id 22472952)1 Kempf W....Kutzner H. (2012)
    47. Assessment of different biomarkers provides valuable d iagnostic standards in the evaluation of the risk of acute rejection. (PubMed id 22759804)1 Zheng J....Xue W. (2012)
    48. The expression of CXCR3 and CD30 in mycosis fungoides. (PubMed id 22369302)1 Nikoo A. (2012)
    49. Deletion of the TNFAIP3/A20 gene detected by FICTION a nalysis in classical Hodgkin lymphoma. (PubMed id 23039325)1 Nomoto J....Kobayashi Y. (2012)
    50. A novel role for reciprocal CD30-CD30L signaling in th e cross-talk between natural killer and dendritic cells. (PubMed id 22628304)1 Simhadri V.L....von Strandmann E.P. (2012)
    51. Distinct motifs in the intracellular domain of human C D30 differentially activate canonical and alternative transcription factor NF-kB signaling. (PubMed id 23028875)1 Buchan S.L. and Al-Shamkhani A. (2012)
    52. Serum levels of soluble CD26 and CD30 and their clinic al significance in patients with rheumatoid arthritis. (PubMed id 22193227)1 Ulusoy H....Ozgocmen S. (2012)
    53. CD30 ligand/CD30 interaction is involved in pathogenes is of inflammatory bowel disease. (PubMed id 22451116)1 Somada S....Tani K. (2012)
    54. Tumor cell nuclear diameter and CD30 expression as pot ential prognostic parameter in patients with extranodal NK/T-cell lymphoma, nasa l type. (PubMed id 23119111)1 Hong J....Lee J.H. (2012)
    55. Galectin-1-mediated cell death is increased by CD30-in duced signaling in anaplastic large cell lymphoma cells but not in Hodgkin lymph oma cells. (PubMed id 21986812)1 Suzuki O....Stein H. (2012)
    56. Soluble CD30: a possible serum tumor marker for primar y effusion lymphoma. (PubMed id 23244086)1 Michai M....Okada S. (2012)
    57. Predicting renal graft failure by sCD30 levels and de novo HLA antibodies at 1year post-transplantation. (PubMed id 22446727)1 Wang D....Tan J. (2012)
    58. Clinical relevance of pre and post-transplant immune m arkers in kidney allograft recipients: anti-HLA and MICA antibodies and serum le vels of sCD30 and sMICA. (PubMed id 22182633)1 Solgi G....Amirzargar A.A. (2012)
    59. Soluble CD30: a serum marker for Epstein-Barr virus-a ssociated lymphoproliferative diseases. (PubMed id 21181928)1 Haque T....Crawford D.H. (2011)
    60. Targeted repression of overexpressed CD30 downregulate s NF-kappaB and ERK1/2 pathway in Hodgkin lymphoma cell lines. (PubMed id 22715589)1 Watanabe M....Horie R. (2011)
    61. Can serum soluble CD23 or CD30 predict the occurrence of lymphoma in HIV-infected patients? (PubMed id 21860351)1 Jarrin I....Sellier P. (2011)
    62. Posttransplant sCD30 as a predictor of kidney graft o utcome. (PubMed id 21505378)1 SA1sal C....Opelz G. (2011)
    63. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    64. Aberrant expression of CD30 in neoplastic mast cells in high-grade mastocytosis. (PubMed id 21186345)1 Sotlar K....Horny H.P. (2011)
    65. Aberrant expression of CD30 in aggressive systemic ma stocytosis and mast cell leukemia: a differential diagnosis to consider in aggr essive hematopoietic CD30-positive neoplasms. (PubMed id 21261503)1 Valent P....Horny H.P. (2011)
    66. Soluble CD30 and Hepatocyte growth factor as predicti ve markers of antibody-mediated rejection of the kidney allograft. (PubMed id 21376809)1 Pavlova Y....Slavcev A. (2011)
    67. Soluble CD30 in normotensive pregnant women with isol ated fetal intrauterine growth restriction: a comparison with preeclamptic wome n. (PubMed id 20591497)1 Laskowska M....Oleszczuk J. (2010)
    68. Increased expression of ganglioside GM1 in peripheral CD4+ T cells correlates soluble form of CD30 in Systemic Lupus Erythematosus p atients. (PubMed id 20625494)1 Dong L....Umehara H. (2010)
    69. Valsartan-induced drug eruption followed by CD30+ pse udolymphomatous eruption. (PubMed id 20814632)1 Sawada Y....Tokura Y. (2010)
    70. A prospective study of serum soluble CD30 in allogene ic hematopoietic stem cell transplantation. (PubMed id 20620210)1 HA1bel K....Hansen H.P. (2010)
    71. Relative reductions in soluble CD30 levels post-trans plant predict acute graft function in islet allograft recipients receiving thre e different immunosuppression protocols. (PubMed id 20600901)1 Hire K....Bansal-Pakala P. (2010)
    72. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    73. CD30 discriminates heat shock protein 60-induced FOXP 3+ CD4+ T cells with a regulatory phenotype. (PubMed id 20631311)1 de Kleer I....Prakken B. (2010)
    74. Soluble CD30 in renal transplant recipients: is it a good biomarker to predict rejection? (PubMed id 20061689)1 Azarpira N....Malekpour Z. (2010)
    75. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    76. Resistance of cutaneous anaplastic large-cell lymphom a cells to apoptosis by death ligands is enhanced by CD30-mediated overexpressi on of c-FLIP. (PubMed id 19890350)1 Braun F.K....Eberle J. (2010)
    77. Pre-transplant soluble CD30 level as a predictor of n ot only acute rejection and graft loss but pneumonia in renal transplant recipi ents. (PubMed id 20036333)1 Wang D....Tan J.M. (2010)
    78. Soluble CD30 and Cd27 levels in patients undergoing H LA antibody-incompatible renal transplantation. (PubMed id 20600903)1 Hamer R....Higgins R. (2010)
    79. Serial soluble CD30 measurements as a predictor of ki dney graft outcome. (PubMed id 20430176)1 Halim M.A....Nampoory M.R. (2010)
    80. Posttransplant soluble CD30 as a predictor of acute r enal allograft rejection. (PubMed id 20353374)1 Kamali K....Rezaie A.R. (2009)
    81. Intradermal CD30-positive mononuclear cells in superficial fungal infections of the skin. (PubMed id 18793267)1 Murphy M. (2009)
    82. Study of the expression of CD30 in pterygia compared to healthy conjunctivas. (PubMed id 19862340)1 Garfias Y....JimAcnez-MartA-nez M.C. (2009)
    83. Plasma sCD26 and sCD30 levels in cutaneous leishmaniasis. (PubMed id 18983807)1 Jafari-Shakib R....Khamesipour A. (2009)
    84. Elevated pretransplantation soluble CD30 is associate d with decreased early allograft function after human lung transplantation. (PubMed id 19126420)1 Shah A.S....Zachary A.A. (2009)
    85. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    86. Local network topology in human protein interaction d ata predicts functional association. (PubMed id 19641626)1 Li H. and Liang S. (2009)
    87. CD30 expression reveals that culture adaptation of hu man embryonic stem cells can occur through differing routes. (PubMed id 19415777)1 Harrison N.J....Andrews P.W. (2009)
    88. TH1/TH2 cytokines and soluble CD30 levels in kidney a llograft patients with donor bone marrow cell infusion. (PubMed id 19765439)1 Solgi G....Nikbin B. (2009)
    89. CD30 expression and proliferative fraction in nontran sformed mycosis fungoides. (PubMed id 19898220)1 Edinger J.T....Swerdlow S.H. (2009)
    90. Expression of the Bcl-2 protein BAD promotes prostate cancer growth. (PubMed id 19593445)1 Smith A.J....Kulik G. (2009)
    91. Soluble CD30 levels in recipients undergoing heart tr ansplantation do not predict post-transplant outcome. (PubMed id 19782609)1 Ypsilantis E....Taylor C.J. (2009)
    92. The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription. (PubMed id 19131627)1 Wright C.W. and Duckett C.S. (2009)
    93. High serum level of the soluble CD30 identifies Chinese kidney transplant recipients at high risk of unfavorable outcome. (PubMed id 19100393)1 Iv R....Chen J.H. (2008)
    94. CD30 serum levels and response to hymenoptera venom immunotherapy. (PubMed id 18714536)1 Foschi F.G....Stefanini G.F. (2008)
    95. The CD30 gene promoter microsatellite binds transcription factor Yin Yang 1 (YY1) and shows genetic instability in anaplastic large cell lymphoma. (PubMed id 17973241)1 Franchina M....Abraham L.J. (2008)
    96. Increased serum levels of soluble CD30 in patients with common variable immunodeficiency and its clinical implications. (PubMed id 17912490)1 Rezaei N....Pourpak Z. (2008)
    97. Level of soluble CD30 after kidney transplantation correlates with acute rejection episodes. (PubMed id 19100394)1 Yang J.L....Na Y.Q. (2008)
    98. Soluble CD30 measured after lung transplantation does not predict bronchiolitis obliterans syndrome in a tacrolimus/mycophenolate mofetil-based immunosuppressive regimen. (PubMed id 18926413)1 Kwakkel-van Erp J.M....van de Graaf E.A. (2008)
    99. Soluble CD30 levels as a diagnostic marker for bronchiolitis obliterans syndrome following human lung transplantation. (PubMed id 18047935)1 Golocheikine A.S....Mohanakumar T. (2008)
    100. CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells. (PubMed id 18187570)1 Hirsch B....Durkop H. (2008)
    101. CD30, a marker to detect the high-risk kidney transplant recipients. (PubMed id 19040559)1 Spiridon C....Mack M. (2008)
    102. Serum soluble CD30 in early arthritis: a sign of inflammation but not a predictor of outcome. (PubMed id 19032830)1 Savolainen E....Kaipiainen-SeppAonen O. (2008)
    103. Does pretransplant soluble CD30 serum concentration affect deceased-donor kidney graft function 3 years after transplantation? (PubMed id 18589105)1 Kovac J....Kandus A. (2008)
    104. Association between serum soluble CD30 and serum crea tinine before and after renal transplantation. (PubMed id 19010142)1 LA^pez-Hoyos M....Arias M. (2008)
    105. Serum neopterin levels in patients with breast cancer. (PubMed id 18320364)1 Yildirim Y....Cetin A. (2008)
    106. Value of soluble CD30 in liver transplantation. (PubMed id 17889168)1 Fabrega E....Romero F.P. (2007)
    107. The levels of sCD30 and of sCD40L in a group of patients with systemic lupus erythematodes and their diagnostic value. (PubMed id 17103120)1 Ciferska H....Scudla V. (2007)
    108. Elevated soluble CD30 characterizes patients with hepatitis C virus-induced liver allograft cirrhosis. (PubMed id 18165785)1 Bharat A....Mohanakumar T. (2007)
    109. High variation of individual soluble serum CD30 levels of pre-transplantation patients: sCD30 a feasible marker for prediction of kidney allograft rejection? (PubMed id 17616534)1 Altermann W....Seliger B. (2007)
    110. Study of gene expression of CD30 variant (CD30v) and CD30 ligand (CD30L) in acute leukemia. (PubMed id 18689277)1 Essa E.A....Farag W. (2007)
    111. Increased expression of CD30 and CD57 molecules on CD4(+) T cells from children with atopic asthma: a preliminary report. (PubMed id 18201430)1 Rojas-Ramos E....Lascurain R. (2007)
    112. Maternal serum soluble CD30 is increased in normal pregnancy, but decreased in preeclampsia and small for gestational age pregnancies. (PubMed id 17853188)1 Kusanovic J.P....Espinoza J. (2007)
    113. Soluble CD26 and CD30 levels in patients with anthroponotic cutaneous leishmaniasis. (PubMed id 17241668)1 Ajdary S....Khamesipour A. (2007)
    114. CD30 (Ber-H2) expression by thymocytes and thymic epithelial cells during the late first and second trimester of gestation: an immunohistochemical and in situ hybridization (ISH) study. (PubMed id 18049429)1 Lambropoulou M....Papadopoulos N. (2007)
    115. Maternal serum soluble CD30 is increased in pregnancies complicated with acute pyelonephritis. (PubMed id 17853184)1 Kusanovic J.P....Hassan S.S. (2007)
    116. Plasma levels of soluble CD30 in kidney graft recipients as predictors of acute allograft rejection. (PubMed id 16980071)1 Ayed K....Kheder A. (2006)
    117. Elevated serum soluble CD30 precedes the development of AIDS-associated non-Hodgkin's B cell lymphoma. (PubMed id 16651853)1 Breen E.C....Martinez-Maza O. (2006)
    118. Evaluation of soluble CD30 as an immunologic marker in heart transplant recipients. (PubMed id 17175368)1 Spiridon C....Nikaein A. (2006)
    119. HLA antibodies and soluble CD30 are associated with poor renal graft outcome: updated results of a single-center cross-sectional study. (PubMed id 18365380)1 Langan L.L....Christiansen F.T. (2006)
    120. Immunoexpression of the CD30 ligand/CD30 and IL-6/IL-6R signals in thyroid autoimmune diseases. (PubMed id 16372246)1 Ruggeri R.M....Trovato M. (2006)
    121. Post-transplant sCD30 and neopterin as predictors of chronic allograft nephropathy: impact of different immunosuppressive regimens. (PubMed id 16771810)1 Weimer R....Opelz G. (2006)
    122. Expression of CD30 (Ber-H2) in nasopharyngeal carcinoma, undifferentiated type and lymphoepithelioma-like carcinoma. A comparison study with anaplastic large cell lymphoma. (PubMed id 16722935)1 Kneile J.R....Wakely P.E. (2006)
    123. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    124. Soluble CD30 concentrations in ESRD patients with and without panel reactive HLA antibodies. (PubMed id 16842522)1 Vaidya S....Gugliuzza K. (2006)
    125. High serum soluble CD30 does not predict acute rejection in liver transplant patients. (PubMed id 17175343)1 Matinlauri I....Isoniemi H. (2006)
    126. Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts. (PubMed id 15782119)1 Nonaka M....Yamaoka S. (2005)
    127. High pre-transplant soluble CD30 levels are predictive of the grade of rejection. (PubMed id 15996240)1 Rajakariar R....Yaqoob M.M. (2005)
    128. CD30 antigen and multiple sclerosis: CD30, an important costimulatory molecule and marker of a regulatory subpopulation of dendritic cells, is involved in the maintenance of the physiological balance between TH1/TH2 immune responses and tolerance. The role of IFNbeta-1a in the treatment of multiple sclerosis. (PubMed id 15990453)1 Pellegrini P....Adorno D. (2005)
    129. Analysis of BCL6-interacting proteins by tandem mass spectrometry. (PubMed id 16147992)1 Miles R.R....Elenitoba-Johnson K.S. (2005)
    130. Stimulation of CD30 in anaplastic large cell lymphoma leads to production of nuclear factor-kappaB p52, which is associated with hyperphosphorylated Bcl-3. (PubMed id 16108830)1 Nishikori M....Uchiyama T. (2005)
    131. Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-kappaB activation. (PubMed id 15876358)1 Higuchi M....Fujii M. (2005)
    132. CD4-veCD8-ve CD30+ve T cells are detectable in human lung transplant patients and their proportion of the lymphocyte population after in vitro stimulation with donor spleen cells correlates with preservation of lung physiology. (PubMed id 15964393)1 Polster K....Leonard C.T. (2005)
    133. Serum sCD30 in monitoring of alloresponse in well HLA-matched cadaveric kidney transplantations. (PubMed id 16378078)1 Matinlauri I.H....Susal C. (2005)
    134. Hodgkin's lymphoma cells are efficiently engrafted and tumor marker CD30 is expressed with constitutive nuclear factor-kappaB activity in unconditioned NOD/SCID/gammac(null) mice. (PubMed id 16108827)1 Dewan M.Z....Yamamoto N. (2005)
    135. sCD30 and neopterin as risk factors of chronic renal transplant rejection: impact of cyclosporine A, tacrolimus, and mycophenolate mofetil. (PubMed id 15919463)1 Weimer R....Opelz G. (2005)
    136. Evaluation of pretransplant immunologic status in kidney-transplant recipients by panel reactive antibody and soluble CD30 determinations. (PubMed id 15880060)1 Cinti P....Molajoni E.R. (2005)
    137. Increased expression and activation of CD30 induce apoptosis in human blood eosinophils. (PubMed id 15265955)1 Berro A.I....Agrawal D.K. (2004)
    138. Roles for CD30 in the biology and treatment of CD30 lymphoproliferative diseases. (PubMed id 15175022)1 Granados S. and Hwang S.T. (2004)
    139. CD30 is involved in inhibition of T-cell proliferation by Hodgkin's Reed-Sternberg cells. (PubMed id 15026356)1 Su C.C....Hsu S.M. (2004)
    140. The ectodomain shedding of CD30 is specifically regulated by peptide motifs in its cysteine-rich domains 2 and 5. (PubMed id 15033921)1 Hansen H.P....Engert A. (2004)
    141. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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    143. Human CD30: structural implications from epitope mapping and modeling studies. (PubMed id 12557237)1 Dong L....Uchanska-Ziegler B. (2003)
    144. Pleiotropic signal transduction mediated by human CD30: a member of the tumor necrosis factor receptor (TNFR) family. (PubMed id 12389614)1 Schneider C. and Hubinger G. (2002)
    145. Single-cell analysis of CD30+ cells in lymphomatoid papulosis demonstrates a common clonal T-cell origin. (PubMed id 12091351)1 Steinhoff M....Stein H. (2002)
    146. Increased levels of soluble CD30 in plasma of patients with Plasmodium falciparum malaria. (PubMed id 11986285)1 Kemp K....Hviid L. (2002)
    147. Soluble CD30 binds to CD153 with high affinity and blocks transmembrane signaling by CD30. (PubMed id 11754357)1 Hargreaves P.G. and Al-Shamkhani A. (2002)
    148. Co-expression of CD30 ligand and interleukin 4 (IL-4) receptors by acute myeloid leukaemia blasts is associated with the expansion of IL-4-producing CD30+ normal T cells. (PubMed id 11918534)1 Rossi F.M....Gattei V. (2002)
    149. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    150. Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells. (PubMed id 10192335)1 Kurts C....Heath W.R. (1999)
    151. CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival. (PubMed id 9353251)1 Duckett C.S. and Thompson C.B. (1997)
    152. TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. (PubMed id 9104814)1 Lee S.Y.... Choi Y. (1997)
    153. Ki-1 (CD30) antigen is released by Ki-1-positive tumor cells in vitro and in vivo. I. Partial characterization of soluble Ki-1 antigen and detection of the antigen in cell culture supernatants and in serum by an enzyme-linked immunosorbent assay. (PubMed id 2537734)1 Josimovic-Alasevic O....Diamantstein T. (1989)
    154. Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population. (PubMed id 6754630)1 Stein H....Diehl V. (1982)
    155. Expression of CD30 mRNA, CD30L mRNA and a variant form of CD30 mRNA in restimulated peripheral blood mononuclear cells (PBMC) of patients with helminthic infections resembling a Th2 disease. (PubMed id 9933429)9 Kilwinski J....Kern P. (1999)
    156. Structure and expression of murine CD30 and its role in cytokine production. (PubMed id 8543792)9 Bowen M.A....Podack E.R. (1996)
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    160. Cloning and characterization of a cDNA for rat CD30 homolog and chromosomal assignment of the genomic gene. (PubMed id 8982082)9 Aizawa S....Watanabe T. (1996)
    161. Preferential expression of CD30 by human CD4+ T cells producing Th2-type cytokines. (PubMed id 7821763)9 Del Prete G....Romagnani S. (1995)
    162. CD30 is a signal-transducing molecule that defines a subset of human activated CD45RO+ T cells. (PubMed id 8103064)9 Ellis T.M....Fisher R.I. (1993)
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    165. A zinc metalloproteinase is responsible for the release of CD30 on human tumor cell lines. (PubMed id 7591296)9 Hansen H.P....Lemke H. (1995)
    166. CD30 antigen in embryonal carcinoma and embryogenesis and release of the soluble molecule. (PubMed id 7856755)9 Latza U....Stein H. (1995)
    167. Expression of Ki-1 antigen (CD30) in mesenchymal tumors. (PubMed id 2169996)9 Mechtersheimer G. and Moller P. (1990)
    168. Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. (PubMed id 16964309)9 Fischer M....Nilsson G. (2006)
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    170. Distinct effects of CD30 and Fas signaling in cutaneous anaplastic lymphomas: a possible mechanism for disease progression. (PubMed id 11121138)9 Levi E....Kadin M.E. (2000)
    171. Expression and regulation of CD30 ligand and CD30 in human leukemia-lymphoma cell lines. (PubMed id 7528856)9 Gruss H.J....Drexler H.G. (1994)
    172. JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell lymphoma and reed-sternberg cells of Hodgkin lymphoma. (PubMed id 16140928)9 Watanabe M....Horie R. (2005)
    173. Expression of CD30 and Ox40 on T lymphocyte subsets is controlled by distinct regulatory mechanisms. (PubMed id 14634058)9 Toennies H.M....Arch R.H. (2004)
    174. Specific immunotherapy effect on interleukin-18 and CD30 serum levels in monosensitized patients with rhinitis. (PubMed id 12866321)9 Ariano R....Gangemi S. (2003)
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    177. Thiols decrease cytokine levels and down-regulate the expression of CD30 on human allergen-specific T helper (Th) 0 and Th2 cells. (PubMed id 11298119)9 Bengtsson A....Scheynius A. (2001)
    178. Human decidual cells can express the Hodgkin's cell-associated antigen Ki-1 (CD30) in spontaneous abortions during the first trimester of gestation. (PubMed id 11838744)9 Papadopoulos N....Tamiolakis D. (2001)
    179. Involvement of Sp1 and microsatellite repressor sequences in the transcriptional control of the human CD30 gene. (PubMed id 10793083)9 Croager E.J....Abraham L.J. (2000)
    180. Characterization of the CD30L binding domain on the human CD30 molecule using anti-CD30 antibodies. (PubMed id 10768840)9 Franke A.C....Ellis T.M. (2000)
    181. A novel domain in the CD30 cytoplasmic tail mediates NFkappaB activation. (PubMed id 9533448)9 Horie R....Watanabe T. (1998)
    182. CD30 expression does not discriminate between human Th1- and Th2-type T cells. (PubMed id 8568238)9 Hamann D....van Lier R.A. (1996)
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    196. Polymorphism of the CD30 promoter microsatellite repressive element is associated with development of primary cutaneous lymphoproliferative disorders. (PubMed id 15894695)9 Franchina M....Abraham L.J. (2005)
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    263. Epstein-Barr virus-associated proliferative disorder presenting as Hodgkin's lymphoma and developing as aggressive natural killer-ce ll leukemia 19 years later: a case report of composite lymphoma. (PubMed id 19269751)9 Oka K....Mori N. (2009)
    264. Lymphocyte depleted Hodgkin lymphoma: an evaluation w ith immunophenotyping and genetic analysis. (PubMed id 19455461)9 Slack G.W....Zukerberg L.R. (2009)
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    266. The relationship between thyroid function, serum monokine induced by interferon gamma and soluble interleukin-2 receptor in thyroid autoimmune diseases. (PubMed id 19250272)9 Jiskra J....LacinovA! Z. (2009)
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    269. Quantitative PCR detection of NPM/ALK fusion gene and CD30 gene expression in patients with anaplastic large cell lymphoma--residual disease monitoring and a correlation with the disease status. (PubMed id 17320171)9 Kalinova M....Kodet R. (2008)
    270. A genomic and expression study of AP-1 in primary cutaneous T-cell lymphoma: evidence for dysregulated expression of JUNB and JUND in MF and SS. (PubMed id 18494816)9 Mao X....Whittaker S.J. (2008)
    271. Large cell transformation mimicking regional lymphoma toid papulosis in a patient with mycosis fungoides. (PubMed id 18477228)9 Nakahigashi K....Miyachi Y. (2008)
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    273. [Intravascular large B-cell lymphoma: report of two autopsy cases with literature review] (PubMed id 19031716)9 Xu X....Li G.D. (2008)
    274. Gastric inflammatory markers and interleukins in patients with functional dyspepsia treated with astaxanthin. (PubMed id 17521392)9 Andersen L.P....WadstrAPm T. (2007)
    275. Common chromosomal abnormalities in mycosis fungoides transformation. (PubMed id 17584911)9 Prochazkova M....Merlio J.P. (2007)
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    277. Pretargeted antibody-guided radioimmunotherapy in a child affected by resistant anaplastic large cell lymphoma. (PubMed id 17655697)9 Palumbo G....Paganelli G. (2007)
    278. Plasma cytokine and soluble receptor signature predicts outcome of patients with classical Hodgkin's lymphoma: a study from the Groupe d'Etude des Lymphomes de l'Adulte. (PubMed id 17389336)9 Casasnovas R.O....Salles G. (2007)
    279. Characterization of the expanded T-cell populations in patients with Wegener's granulomatosis. (PubMed id 16918819)9 Giscombe R....Lefvert A.K. (2006)
    280. Critical, but conditional, role of OX40 in memory T cell-mediated rejection. (PubMed id 16424166)9 Vu M.D....Li X.C. (2006)
    281. A T2 cytokine environment may not limit T1 responses in human immunodeficiency virus patients with a favourable response to antiretroviral therapy. (PubMed id 16792698)9 Price P....French M.A. (2006)
    282. Human embryonal tissues of all three germ layers can express the CD30 antigen. An immunohistochemical study of 30 fetuses coming after therapeutic abortions from week 8th to week 16th of gestation. (PubMed id 16506595)9 Tamiolakis D....Kouskoukis C. (2006)
    283. Ki-1/57 interacts with PRMT1 and is a substrate for arginine methylation. (PubMed id 16879614)9 Passos D.O....Kobarg J. (2006)
    284. CD30+ lymphoproliferative disorders: histopathology, differential diagnosis, new variants, and simulators. (PubMed id 16412214)9 Kempf W. (2006)
    285. Eosinophilic ulcer of the oral mucosa: another histological simulator of CD30+ lymphoproliferative disorders. (PubMed id 16882190)9 Segura S....Estrach T. (2006)
    286. ALK-positive anaplastic large cell lymphoma with primary bone involvement in children. (PubMed id 16482992)9 Bakshi N.A....Schnitzer B. (2006)
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    288. Gastric inflammatory markers and interleukins in patients with functional dyspepsia, with and without Helicobacter pylori infection. (PubMed id 15866221)9 Andersen L.P....WadstrAPm T. (2005)
    289. De novo CD5-positive diffuse large B-cell lymphoma of the skin arising in chronic limb lymphedema. (PubMed id 16019518)9 Dargent J.L....Bron D. (2005)
    290. JunB expression is a common feature of CD30+ lymphomas and lymphomatoid papulosis. (PubMed id 15920551)9 Rassidakis G.Z....Medeiros L.J. (2005)
    291. TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. (PubMed id 15708970)9 Hauer J....Engelmann H. (2005)
    292. Reappraisal of BCL3 as a molecular marker of anaplastic large cell lymphoma. (PubMed id 16533741)9 Ohno H....Haga H. (2005)
    293. CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease. (PubMed id 15322151)9 Blazar B.R....Taylor P.A. (2004)
    294. Molecular cloning and characterization of chicken tumor necrosis factor (TNF)-superfamily ligands, CD30L and TNF-related apoptosis inducing ligand (TRAIL). (PubMed id 15240938)9 Abdalla S.A....Matsuda H. (2004)
    295. Malignant melanoma with a rhabdoid phenotype: histologic, immunohistochemical, and ultrastructural study of a case and review of the literature. (PubMed id 15163228)9 Abbott J.J....Hoang M.P. (2004)
    296. Frequent expression of CD30 antigen in the primary gastric non-B, non-Hodgkin lymphomas. (PubMed id 15189504)9 Iwamizu-Watanabe S....Mori N. (2004)
    297. Posttransplant lymphoproliferative disorder presenting as CD30+, ALK+, anaplastic large cell lymphoma in a child. (PubMed id 15148593)9 Sebire N.J....Ramsay A.D. (2004)
    298. [Pathologic diagnosis and subtyping of lymphoma in bone marrow biopsies using histologic examination, immunohistochemistry and gene rearrangement studies] (PubMed id 15132847)9 Xiao J.C....Yuan F. (2004)
    299. Lacunar and reed-sternberg-like cells in follicular lymphomas are clonally related to the centrocytic and centroblastic cells as demonstrated by laser capture microdissection. (PubMed id 15539378)9 Bayerl M.G....Palutke M. (2004)
    300. [Pathologic diagnoses of core needle biopsies of the mediastinum] (PubMed id 15132850)9 Liu M....Li X.H. (2004)
    301. Neutrophil-rich anaplastic large cell lymphoma presenting in the skin. (PubMed id 12652196)9 Kato N....Shibata M. (2003)
    302. T cell receptor-gamma gene analysis of CD30+ large atypical individual cells in CD30+ large primary cutaneous T cell lymphomas. (PubMed id 12648233)9 Gellrich S....Sterry W. (2003)
    303. Anaplastic large cell lymphoma--a rare disorder in southern Taiwan. (PubMed id 14692525)9 Lin C.N....Chuang S.S. (2003)
    304. Comparison of fascin expression in anaplastic large cell lymphoma and Hodgkin disease. (PubMed id 12579989)9 Fan G....Braziel R.M. (2003)
    305. CXCR4/CD184 immunoreactivity in T-cell non-Hodgkin lymphomas with an overall Th1- Th2+ immunophenotype. (PubMed id 12645345)9 Weng A.P....Dorfman D.M. (2003)
    306. Epithelial membrane antigen (EMA) or MUC1 expression in monocytes and monoblasts. (PubMed id 14555387)9 Leong C.F....Noor Hamidah H. (2003)
    307. [Immunophenotype of peripheral blood mononuclear cells in atopic diseases] (PubMed id 15058161)9 Pitsch T....Rogala B. (2003)
    308. Primary central nervous system cytotoxic/suppressor T-cell lymphoma: report of a unique case and review of the literature. (PubMed id 12717253)9 Liu D....Hutchison R.E. (2003)
    309. Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? (PubMed id 12974476)9 Croft M. (2003)
    310. Epstein-Barr virus-associated peripheral T-Cell lymphoma involving spleen in a renal transplant patient. (PubMed id 12692428)9 Lee H.K....Yang W.I. (2003)
    311. [Hodgkin's and Reed-Sternberg cells in the peripheral blood of a patient with advanced stage Hodgkin's disease] (PubMed id 15058220)9 MiloseviA8 R....BogunoviA8 M. (2003)
    312. Anaplastic large-cell lymphoma (Ki-1 lymphoma): ultrastructural and immunohistochemical studies. (PubMed id 12353136)9 Hirano H....Mori H. (2002)
    313. An ultrastructural study of cutaneous panniculitis-like T-cell lymphoma: cytoplasmic granules and active cellular and cell-to-matrix interaction mimic cytotoxic T-cells. (PubMed id 12184377)9 Yamazaki K. (2002)
    314. Characterization of a novel human anaplastic large cell lymphoma cell line tumorigenic in SCID mice. (PubMed id 11908723)9 Merz H....Feller A.C. (2002)
    315. Relapsed Hodgkin's lymphoma: immunostaining patterns in relation to survival. (PubMed id 12152993)9 Amini R.M....SundstrAPm C. (2002)
    316. Concentrations of cytokines, soluble interleukin-2 receptor, and soluble CD30 in sera of patients with hepatitis B virus infection during acute and convalescent phases. (PubMed id 12414777)9 Monsalve-De Castillo F....Callejas D. (2002)
    317. Clinical significance of serum neuron-specific enolase in patients with adult T-cell leukemia. (PubMed id 12353304)9 Fujiwara H....Tei C. (2002)
    318. [Clinico-immunological characteristics of lymphoid tumors in children] (PubMed id 11882963)9 Makhonova L.A....Sholokhova E.N. (2002)
    319. TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism. (PubMed id 12193714)9 Harlin H....Alegre M.L. (2002)
    320. [Immunophenotype and differential diagnosis of Hodgkin's lymphoma] (PubMed id 12482349)9 Liu Y....Cai X. (2002)
    321. Diagnosis and differential diagnosis of nodular lymph ocyte-predominant Hodgkin's lymphoma. (PubMed id 12475440)9 Liu Y....Luo X. (2002)
    322. Anaplastic lymphoma kinase (ALK) protein expressing lymphoma after liver transplantation: case report and literature review. (PubMed id 12401829)9 Costes-Martineau V....Delsol G. (2002)
    323. Primary Ki-1 lymphoma in the central nervous system. (PubMed id 11683612)9 Kawamura T....Fukui M. (2001)
    324. Primary effusion lymphoma with herpesvirus 8 DNA in p atients coinfected with HIV and hepatitis C virus: a report of 2 cases. (PubMed id 11570267)9 Hong S. and Krafft A.E. (2001)
    325. Primary anaplastic large cell lymphoma of the spleen presenting as a splenic abscess. (PubMed id 11911429)9 Sakadamis A....Rafailidis S. (2001)
    326. [Differential diagnostic and prognostic value of serum cytokines (soluble CD30, soluble interleukin-2 receptor, interleukin-10 and interleukin-6) in Hodgkin's disease and lymphosarcomas] (PubMed id 11494447)9 Iaguzhinskaia O.E....Pivnik A.V. (2001)
    327. Pathologic and clinical features of 77 Hodgkin's lymphoma patients treated in a lymphoma protocol (LNH87): a GELA study. (PubMed id 11224599)9 Cazals-Hatem D....Gaulard P. (2001)
    328. Primary cerebral anaplastic large cell lymphoma containing abundant reactive histiocytes and eosinophils. A case report and literature review. (PubMed id 11569930)9 Chuang S.S....Shen C.H. (2001)
    329. Primary Epstein-Barr virus-associated Hodgkin disease of the ileum complicating Crohn disease. (PubMed id 11231497)9 Li S. and Borowitz M.J. (2001)
    330. Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4--anaplastic lymphoma kinase gene fusion. (PubMed id 11493472)9 Meech S.J....Hunger S.P. (2001)
    331. MUC1 (EMA) is preferentially expressed by ALK positive anaplastic large cell lymphoma, in the normally glycosylated or only partly hypoglycosylated form. (PubMed id 11729213)9 ten Berge R.L....Meijer C.J. (2001)
    332. Il-4 influences apoptosis of mycobacterium-reactive lymphocytes in the presence of TNF-alpha. (PubMed id 11466338)9 Seah G.T. and Rook G.A. (2001)
    333. Segregation of effector mechanisms in a tumour-specific CD8+ T-cell clone correlates with CD30 expression. (PubMed id 11555396)9 Sun Y....Schadendorf D. (2001)
    334. Further support for a role for Th2-like cytokines in blister formation of pemphigus. (PubMed id 11161984)9 Caproni M....Fabbri P. (2001)
    335. [Primary Ki-1 positive anaplastic large cell non-Hodgkin's lymphoma of the lung. A case study and review of the literature] (PubMed id 11862770)9 BeltrA!n BeltrA!n S....Ferreras FernA!ndez P. (2001)
    336. [Primary cutaneous CD30-positive anaplastic large cell lymphoma] (PubMed id 11866962)9 Shi Q....Qian B. (2001)
    337. Combining phage display and screening of cDNA expression libraries: a new approach for identifying the target antigen of an scFv preselected by phage display. (PubMed id 10966781)9 Barth S....Engert A. (2000)
    338. Lymphohistiocytic anaplastic large cell lymphoma stage I: long-term survival after resection alone. (PubMed id 10779993)9 Kedar A. and Braylan R.C. (2000)
    339. Granzyme B-positive primary gastric T-cell lymphoma: gastric T-cell lymphoma with the possibility of extrathymic T cell origin. (PubMed id 11107059)9 Murata T....Shiraishi T. (2000)
    340. Expression of the CD30 antigen in non-lymphoid tissues and cells. (PubMed id 10727988)9 DA1rkop H....Stein H. (2000)
    341. Anaplastic large cell lymphoma arising in bone: report of a case of the monomorphic variant with the t(2;5)(p23;q35) translocation. (PubMed id 10975933)9 Lones M.A....Medeiros L.J. (2000)
    342. Immune recruitment by bispecific antibodies for the treatment of Hodgkin disease. (PubMed id 10950145)9 da Costa L....Pfreundschuh M. (2000)
    343. Human CD4+ T lymphocytes with remarkable regulatory functions on dendritic cells and nickel-specific Th1 immune responses. (PubMed id 10651989)9 Cavani A....Girolomoni G. (2000)
    344. Anaplastic large cell lymphomas presented as bone lesions: a clinicopathologic study of six cases and review of the literature. (PubMed id 11048810)9 Nagasaka T....Lai R. (2000)
    345. A case of anaplastic lymphoma kinase-positive anaplastic large cell lymphoma presenting with spontaneous splenic rupture: an extremely unusual presentation. (PubMed id 11097375)9 Hebeda K.M....van Krieken J.H. (2000)
    346. Immunohistochemical analysis of CD30-positive lymphoproliferative disorders for expression of CD95 and CD95L. (PubMed id 10786813)9 Sigel J.E. and Hsi E.D. (2000)
    347. Initiation of humoral and cellular immune responses in patients with refractory Hodgkin's disease by treatment with an anti-CD16/CD30 bispecific antibody. (PubMed id 10881697)9 Renner C....Pfreundschuh M. (2000)
    348. Sinusoidal CD30-positive large B-cell lymphoma: a morphologic mimic of anaplastic large cell lymphoma. (PubMed id 10757332)9 Lai R....Coupland R.W. (2000)
    349. Analysis of TNF-receptor and ligand superfamily molecules in patients with lymphoproliferative disease of granular lymphocytes. (PubMed id 10887130)9 Zambello R....Semenzato G. (2000)
    350. Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo. (PubMed id 10331500)9 Annunziato F....Maggi E. (1999)
    351. Nodal cytotoxic lymphoma spectrum: a clinicopathologic study of 66 patients. (PubMed id 10524519)9 Kagami Y....Nakamura S. (1999)
    352. Epstein-Barr virus-associated intravascular lymphomatosis within Kaposi's sarcoma in an AIDS patient. (PubMed id 10199480)9 Hsiao C.H....How S.W. (1999)
    353. Primary anaplastic large cell lymphoma of the central nervous system. (PubMed id 10452512)9 Abdulkader I....Forteza J. (1999)
    354. The Fanconi anemia group C gene product modulates apoptotic responses to tumor necrosis factor-alpha and Fas ligand but does not suppress expression of receptors of the tumor necrosis factor receptor superfamily. (PubMed id 9923438)9 Koh P.S....Bagby G.C. (1999)
    355. Primary cutaneous Ki-1(CD30) positive anaplastic large cell lymphoma in childhood. (PubMed id 10321635)9 Tomaszewski M.M....Lupton G.P. (1999)
    356. CD3+/CD30+ circulating T lymphocytes are markedly increased in older subjects with Down's syndrome (Trisomy 21). (PubMed id 10023139)9 Bertotto A....Vaccaro R. (1999)
    357. Leukaemic presentation of small cell variant anaplastic large cell lymphoma: report of four cases. (PubMed id 10192426)9 Bayle C....Delsol G. (1999)
    358. Neuron-specific enolase (gamma enolase, gamma-gamma dimer) expression in Hodgkin's disease and large cell lymphomas. (PubMed id 10628334)9 Massarelli G....Tanda F. (1999)
    359. A murine xenograft model for human CD30+ anaplastic large cell lymphoma. Successful growth inhibition with an anti-CD30 antibody (HeFi-1). (PubMed id 10514417)9 Pfeifer W....Kadin M.E. (1999)
    360. NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27. (PubMed id 9794406)9 Yamamoto H....Minamoto S. (1998)
    361. Primary manifestation of Hodgkin's disease in the central nervous system. (PubMed id 9645450)9 Deckert-SchlA1ter M....Wiestler O.D. (1998)
    362. Tumour necrosis factor (TNF) and TNF-related molecules in HIV-1+ individuals: relationship with in vitro Th1/Th2-type response. (PubMed id 9764604)9 Rizzardi G.P....Barcellini W. (1998)
    363. Dual action of CD30 antigen: anti-CD30 antibody induced apoptosis and interleukin-8 secretion in Ki-1 lymphoma cells. (PubMed id 9650447)9 Masuda M....Mizoguchi H. (1998)
    364. Characteristics and prognosis of KI-1 positive anaplastic large cell lymphoma in Asians. (PubMed id 9972408)9 Lee S.C....Wong J. (1998)
    365. Cutaneous CD30+ lymphoproliferative disorders: expression of bcl-2 and proteins of the tumor necrosis factor receptor superfamily. (PubMed id 9824099)9 Paulli M....Kadin M.E. (1998)
    366. Anaplastic large cell malignant lymphoma with extensive eosinophilic or neutrophilic infiltration. (PubMed id 9543666)9 McCluggage W.G....Bharucha H. (1998)
    367. CD30-ligand and CD40-ligand expression in lymph nodes involved with Hodgkin's disease. (PubMed id 9209650)9 Younes A....Andreeff M. (1997)
    368. Carbamazepine-induced lymphadenopathy mimicking Ki-1 (CD30+) T-cell lymphoma. (PubMed id 9094181)9 Yeo W....Johnson P.J. (1997)
    369. The role of eosinophils in the pathobiology of Hodgkin's disease. (PubMed id 9209649)9 Pinto A....Carbone A. (1997)
    370. T-helper 2 involvement in the pathogenesis of bullous pemphigoid: role of soluble CD30 (sCD30). (PubMed id 9452886)9 De PitA! O....Puddu P. (1997)
    371. CD30+ lymphocytes in chronic gingivitis from HIV-positive patients: a pilot study. (PubMed id 9379333)9 Gomez R.S....Araujo N.S. (1997)
    372. [Flow cytometry for extensive thoracic diagnosis] (PubMed id 9206929)9 Bernhardt K. (1997)
    373. Cytologic diagnosis of Ki-1 lymphoma in pleural and p eritoneal effusions: a case report. (PubMed id 9258621)9 Burja I.T....Brown E.J. (1997)
    374. Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells. (PubMed id 9434163)9 Tan K.B....Truneh A. (1997)
    375. Diffuse large cell, B-cell type lymphoma with a novel translocation (2;22)(p23;q11.2). (PubMed id 9216718)9 Park J.P....Mohandas T.K. (1997)
    376. Adult T-cell leukemia/lymphoma with features of CD30-positive anaplastic large cell lymphoma--a case report. (PubMed id 9288638)9 Lee S.N....Hong S.I. (1997)
    377. Most primary cutaneous CD30-positive lymphoproliferative disorders have a CD4-positive cytotoxic T-cell phenotype. (PubMed id 9347791)9 Kummer J.A....Willemze R. (1997)
    378. Treatment of refractory Hodgkin's disease with an anti-CD16/CD30 bispecific antibody. (PubMed id 9058726)9 Hartmann F....Pfreundschuh M. (1997)
    379. Patients suffering from both Hodgkin's disease and non-Hodgkin's lymphoma: a clinico-pathological and immuno-histochemical population-based study of 32 patients. (PubMed id 9178801)9 Amini R.M....Glimelius B. (1997)
    380. [Cutaneous T-cell lymphoma of the mycosis fungoides type in the area of the eyelid and lacrimal ducts] (PubMed id 9206737)9 Aaliouet H....SAPnnichsen K. (1997)
    381. Traumatic eosinophilic granuloma of the oral mucosa: a CD30+(Ki-1) lymphoproliferative disorder? (PubMed id 9415340)9 Ficarra G....Romagnoli P. (1997)
    382. Distinctive clinicopathologic features associated with regressive primary CD30 positive cutaneous lymphomas: analysis of 6 cases. (PubMed id 9085151)9 Bernier M....Wechsler J. (1997)
    383. Expression of CD95 antigen and Bcl-2 protein in non-Hodgkin's lymphomas and Hodgkin's disease. (PubMed id 8774139)9 Nguyen P.L....Robertson M.J. (1996)
    384. CD30 ligand, a member of the TNF ligand superfamily, with growth and activation control CD30+ lymphoid and lymphoma cells. (PubMed id 8833395)9 Gruss H-J . and Herrmann F. (1996)
    385. Phenotypic modulation of Hodgkin and Reed-Sternberg cells by Epstein-Barr virus. (PubMed id 8691346)9 Herbst H....Stein H. (1996)
    386. Expression of tumor necrosis factor-receptor superfamily members by lung T lymphocytes in interstitial lung disease. (PubMed id 8616567)9 Agostini C....Semenzato G. (1996)
    387. Anaplastic large cell Ki-1 lymphoma: primary bone presentation in an elderly man. (PubMed id 8677761)9 Wang J.C....Goldberg M. (1996)
    388. Primary Ki-1-positive T-cell lymphoma of the brain--an aggressive subtype of lymphoma: case report and review of the literature. (PubMed id 8677486)9 Goldbrunner R....Roosen K. (1996)
    389. Amplification of genomic DNA demonstrates the presence of the t(2;5) (p23;q35) in anaplastic large cell lymphoma, but not in other non-Hodgkin's lymphomas, Hodgkin's disease, or lymphomatoid papulosis. (PubMed id 8781434)9 Sarris A.H....Pugh W.C. (1996)
    390. Induction of apoptosis by ribosome-inactivating proteins and related immunotoxins. (PubMed id 8903477)9 Bolognesi A....Stirpe F. (1996)
    391. Fine needle aspiration cytology, histology and immunohistochemistry of anaplastic large cell Ki-1-positive lymphoma. A report of three cases. (PubMed id 8693905)9 McCluggage W.G....Caughley L. (1996)
    392. Plasma levels of soluble CD30, tumour necrosis factor (TNF)-alpha and TNF receptors during primary HIV-1 infection: correlation with HIV-1 RNA and the clinical outcome. (PubMed id 8931778)9 Rizzardi G.P....Lazzarin A. (1996)
    393. CD30-positive cutaneous large cell lymphomas. A comparative study of clinicopathologic and molecular features of 16 cases. (PubMed id 8604686)9 Macgrogan G....Merlio J.P. (1996)
    394. Cytology of extranodal Ki-1 anaplastic large cell lymphoma. (PubMed id 8964173)9 Zakowski M.F....Filippa D.A. (1996)
    395. Human eosinophils express functional CD30 ligand and stimulate proliferation of a Hodgkin's disease cell line. (PubMed id 8896393)9 Pinto A....Carbone A. (1996)
    396. Pleomorphic large cell lymphomas of the mediastinum. (PubMed id 8554112)9 Suster S. and Moran C.A. (1996)
    397. Single-cell analysis of T-cell receptor-gamma rearrangements in large-cell anaplastic lymphoma. (PubMed id 8919540)9 Lorenzen J....Hansmann M.L. (1996)
    398. CD30 expression in seminoma. (PubMed id 8912826)9 Hittmair A....Feichtinger H. (1996)
    399. Prognostic significance of immunological evaluation in colorectal cancer. (PubMed id 10851496)9 Berghella A.M....Casciani C.U. (1996)
    400. CD30/Ki-1-positive lymphoproliferative disorders of the skin--clinicopathologic correlation and statistical analysis of 86 cases: a multicentric study from the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Project Group. (PubMed id 7751878)9 Paulli M....Santucci M. (1995)
    401. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. (PubMed id 7539037)9 Katsikis P.D....Herzenberg L.A. (1995)
    402. Inflammatory pseudotumour of lymph nodes. (PubMed id 7706516)9 New N.E....Harris M. (1995)
    403. Treatment of heterotransplanted Hodgkin's tumors in SCID mice by a combination of human NK or T cells and bispecific antibodies. (PubMed id 8581383)9 Renner C. and Pfreundschuh M. (1995)
    404. Primary cutaneous Ki-1+ anaplastic large cell lymphoma: a morphologic, immunohistochemical and genetic study of an indolent case. (PubMed id 7650245)9 Sato N....Tomita Y. (1995)
    405. Nasal natural killer (NK) cell lymphoma: report of a case with activated NK cells containing Epstein-Barr virus and expressing CD21 antigen, and comparative studies of their phenotype and cytotoxicity with normal NK cells. (PubMed id 8547075)9 Kaneko T....Oshimi K. (1995)
    406. Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas. (PubMed id 7780126)9 Gruss H.J. and Dower S.K. (1995)
    407. Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein. (PubMed id 7737295)9 Birkeland M.L....Barclay A.N. (1995)
    408. Soluble ICAM-1 in Hodgkin's disease: a promising independent predictive marker for survival. (PubMed id 8535215)9 Christiansen I....TAPtterman T.H. (1995)
    409. [Large cell anaplastic Ki-1 positive lymphoma of the skin. 5 personal cases and review of the literature] (PubMed id 7875968)9 Trautmann C....Orfanos C.E. (1995)
    410. A new t(2;5) translocation in a null cell type CD30 positive anaplastic large cell lymphoma case. (PubMed id 7564510)9 Wlodarska I....Van den Berghe H. (1995)
    411. SBH-1, a novel Reed-Sternberg-like cell line capable of inducing tumors in SCID mice: immunophenotypic, cytogenetic, and cytokine expression profiles. (PubMed id 7742544)9 DeCoteau J.F....Pinkerton P.H. (1995)
    412. [Large-cell anaplastic malignant CD30/Ki-1-positive T-type lymphoma, associated with STLV-1 virus (baboon malignant lymphoma model] (PubMed id 7615247)9 Iakovleva L.A....Lapin B.A. (1995)
    413. The role of lymphocyte subsets and adhesion molecules in T cell-dependent cytotoxicity mediated by CD3 and CD28 bispecific monoclona l antibodies. (PubMed id 7621876)9 Renner C....Pfreundschuh M. (1995)
    414. Molecular characterization of CD30+ anaplastic large-cell lymphoma: high frequency of c-myc proto-oncogene activation. (PubMed id 8204884)9 Inghirami G....Knowles D.M. (1994)
    415. Detection of Epstein-Barr virus small RNAs in routine paraffin sections using non-isotopic RNA/RNA in situ hybridization. (PubMed id 7982672)9 Hamilton-Dutoit S.J. and Pallesen G. (1994)
    416. T-cell lymphoma of the tonsil with Ki-1 antigen expression. (PubMed id 7949650)9 Yoshioka K....Andachi H. (1994)
    417. Monocyte/macrophage system and malignancies. (PubMed id 8084313)9 Schmidt D. (1994)
    418. Ber-H2 expression in testicular germ cell tumors. (PubMed id 8200647)9 Ferreiro J.A. (1994)
    419. Nucleophosmin (NPM) gene rearrangements in Ki-1-positive lymphomas. (PubMed id 8187071)9 Bullrich F....Croce C.M. (1994)
    420. Positive selection of hematopoietic CD34+ stem cells provides 'indirect purging' of CD34- lymphoid cells and the purging efficiency is increased by anti-CD2 and anti-CD30 immunotoxins. (PubMed id 7517259)9 Lemoli R.M....Tura S. (1994)
    421. A Ki-1-positive cell line expressing Epstein-Barr virus antigens, established from a child with Ki-1-positive lymphoma. (PubMed id 8169113)9 Shimakage M....Ikegami N. (1993)
    422. High-grade pleomorphic T cell lymphoma with restricted involvement of skin and bone marrow. (PubMed id 8513200)9 Gautier M.S....LapiA"re C.M. (1993)
    423. Anaplastic large cell lymphoma (Ki-1+/CD30+) in childhood. (PubMed id 8390600)9 Vecchi V....Paolucci G. (1993)
    424. KP1 (CD68)-positive large cell lymphomas: a histopathologic and immunophenotypic characterization of 12 cases. (PubMed id 7690736)9 Carbone A....Pinto A. (1993)
    425. Voluminous solitary non-Hodgkin extraganglionary lymphoma of thigh. (PubMed id 7849284)9 Laky D. and DumitraA9cu G.H. (1993)
    426. CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. (PubMed id 8391931)9 Smith C.A.... Armitage R.J. (1993)
    427. Active specific immunotherapy of Hodgkin's lymphoma by an anti-idiotype vaccine against the Hodgkin-associated CD30 antigen. (PubMed id 8396378)9 Renner C....Pohl C. (1993)
    428. CD30-specific AB1-AB2-AB3 internal image antibody network: potential use as anti-idiotype vaccine against Hodgkin's lymphoma. (PubMed id 8389737)9 Pohl C....Diehl V. (1993)
    429. Ki-1-positive large cell anaplastic lymphoma diagnosed by urinary cytology. A case report. (PubMed id 8392254)9 Tanaka T....Mori H. (1993)
    430. Quantitative approach to the immunohistochemical analysis of p53 antioncogene and CD30 antigen in Hodgkin' disease. (PubMed id 8218985)9 Chilosi M....Mariuzzi G.M. (1993)
    431. Cutaneous manifestations of Epstein-Barr virus-associated T-cell lymphoma. (PubMed id 8227539)9 Su I.J....Chen C.C. (1993)
    432. Endomyocardial biopsies after heart transplantation. The presence of markers indicative of activation. (PubMed id 8420034)9 Wijngaard P.L....Schuurman H.J. (1993)
    433. Lethal midline granuloma (peripheral T-cell lymphoma) after lymphomatoid papulosis. (PubMed id 1322784)9 Harabuchi Y....Kon S. (1992)
    434. [Non-Hodgkin lymphoma with Ki-1 antigen: a case report] (PubMed id 1329671)9 Nakamura S. and Shiigai T. (1992)
    435. Large cell lymphoma of the mediastinum with marked tropism for germinal centers. (PubMed id 1591683)9 Suster S. (1992)
    436. A rare entity among childhood malignant lymphomas (large anaplastic T-cell Ki-1 +). (PubMed id 1509528)9 Ulukutlu L....Maurer R. (1992)
    437. [Adult T-cell leukemia/lymphoma, histologically presenting Ki-1 positive anaplastic large cell lymphoma] (PubMed id 1335094)9 Hashimoto K....Tago H. (1992)
    438. Cellular localizations and processing of the two molecular forms of the Hodgkin-associated Ki-1 (CD30) antigen. The protein kinase Ki-1/57 occurs in the nucleus. (PubMed id 1310832)9 Rohde D....Lemke H. (1992)
    439. Malignant histiocytosis in childhood: a distinctive CD30-positive clinicopathological entity associated with a chromosomal translocation involving 5q35. (PubMed id 1313990)9 Nezelof C....Terrier-Lacombe M.J. (1992)
    440. Soluble CD8, CD25 and CD30 antigens as prognostic markers in patients with untreated Hodgkin's lymphoma. (PubMed id 1333270)9 Gause A....Pfreundschuh M. (1992)
    441. Immunoarchitecture of normal human bone marrow: a study of frozen and fixed tissue sections. (PubMed id 1592393)9 Shin S.S....Winberg C.D. (1992)
    442. Paraffin section immunohistochemistry in the diagnosis of Hodgkin's disease and anaplastic large cell (CD30+) lymphomas. (PubMed id 1376944)9 Carbone A....Volpe R. (1992)
    443. Histiocytes in familial and infection-induced/idiopathic hemophagocytic syndromes may exhibit phenotypic differences. (PubMed id 1348582)9 Buckley P.J....Komp D.M. (1992)
    444. Response of refractory Hodgkin's disease to monoclonal anti-CD30 immunotoxin. (PubMed id 1349939)9 Falini B....Pizzolo G. (1992)
    445. Phenotyping and genotyping of composite lymphoma with Ki-1 component. (PubMed id 1337078)9 Sun T....Rogers C. (1992)
    446. Childhood Ki-1 lymphoma: presentation as a buttock mass. (PubMed id 1724356)9 Winter S.S....Cartwright K.C. (1991)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 943 HGNC: 11923 AceView: TNFRSF8 Ensembl:ENSG00000120949 euGenes: HUgn943
    ECgene: TNFRSF8 Kegg: 943 H-InvDB: TNFRSF8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for TNFRSF8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF8 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf8/

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