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TNFRSF8 Gene(Protein Coding)

Tumor Necrosis Factor Receptor Superfamily Member 8

GCID:
GC01P012123
GIFtS:
64
Genes Participants
UDN Logo

Aliases for TNFRSF8 Gene

Aliases for TNFRSF8 Gene

  • Tumor Necrosis Factor Receptor Superfamily Member 8 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 8 2 3
  • Lymphocyte Activation Antigen CD30 3 4
  • CD30L Receptor 3 4
  • Ki-1 Antigen 3 4
  • D1S166E 3 4
  • CD30 3 4
  • Cytokine Receptor CD30 3
  • CD30 Antigen 4
  • Ki-1 3

External Ids for TNFRSF8 Gene

Previous HGNC Symbols for TNFRSF8 Gene

  • CD30
  • D1S166E

Previous GeneCards Identifiers for TNFRSF8 Gene

  • GC01P012187
  • GC01P011968
  • GC01P011732
  • GC01P011832
  • GC01P012057
  • GC01P011277

Summaries for TNFRSF8 Gene

Entrez Gene Summary for TNFRSF8 Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF8 Gene

TNFRSF8 (Tumor Necrosis Factor Receptor Superfamily Member 8) is a Protein Coding gene. Diseases associated with TNFRSF8 include Anaplastic Large Cell Lymphoma and Lymphomatoid Papulosis. Among its related pathways are TNF Signaling (sino) and ERK Signaling. GO annotations related to this gene include transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for TNFRSF8 Gene

  • Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.

Gene Wiki entry for TNFRSF8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF8 Gene

Genomics for TNFRSF8 Gene

Products:

  1. Regulatory Element

Regulatory Elements for TNFRSF8 Gene

Enhancers for TNFRSF8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TNFRSF8 on UCSC Golden Path with GeneCards custom track

Promoters for TNFRSF8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNFRSF8 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TNFRSF8 gene promoter:

Genomic Location for TNFRSF8 Gene

Chromosome:
1
Start:
12,063,330 bp from pter
End:
12,144,207 bp from pter
Size:
80,878 bases
Orientation:
Plus strand

Genomic View for TNFRSF8 Gene

Genes around TNFRSF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TNFRSF8 Gene

Proteins for TNFRSF8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TNFRSF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28908-TNR8_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 8
    Protein Accession:
    P28908
    Secondary Accessions:
    • B1AN79
    • B9EGD9
    • D3YTD8
    • Q6P4D9

    Protein attributes for TNFRSF8 Gene

    Size:
    595 amino acids
    Molecular mass:
    63747 Da
    Quaternary structure:
    • Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.
    Miscellaneous:
    • Most specific Hodgkin disease associated antigen.

    Three dimensional structures from OCA and Proteopedia for TNFRSF8 Gene

    Alternative splice isoforms for TNFRSF8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFRSF8 Gene

Proteomics data for TNFRSF8 Gene at MOPED

Protein Expression for TNFRSF8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TNFRSF8 Gene

  • Phosphorylated on serine and tyrosine residues.
  • Glycosylation at Asn 101, Thr 209, and Asn 276
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFRSF8 Gene

Domains & Families for TNFRSF8 Gene

Gene Families for TNFRSF8 Gene

HGNC:
IUPHAR :

Protein Domains for TNFRSF8 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNFRSF8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28908

UniProtKB/Swiss-Prot:

TNR8_HUMAN :
  • Contains 6 TNFR-Cys repeats.
Similarity:
  • Contains 6 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF8: view

Function for TNFRSF8 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for TNFRSF8 Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 8,cell differentiation antigen CD30 (Ki-1),lymphoid activating,identified by monoclonal antibodies HRS-1,Ki-1
UniProtKB/Swiss-Prot Function:
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.

Gene Ontology (GO) - Molecular Function for TNFRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TNFRSF8: view

Phenotypes for TNFRSF8 Gene

MGI mutant phenotypes for TNFRSF8:
inferred from 1 alleles
GenomeRNAi human phenotypes for TNFRSF8:
genes like me logo Genes that share phenotypes with TNFRSF8: view

Animal Models for TNFRSF8 Gene

MGI Knock Outs for TNFRSF8:

Animal Model Products

CRISPR Products

miRNA for TNFRSF8 Gene

miRTarBase miRNAs that target TNFRSF8

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF8 Gene

Localization for TNFRSF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF8 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNFRSF8 Gene COMPARTMENTS Subcellular localization image for TNFRSF8 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
cytosol 2
lysosome 2
nucleus 2
vacuole 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for TNFRSF8 Gene

Pathways & Interactions for TNFRSF8 Gene

genes like me logo Genes that share pathways with TNFRSF8: view

Gene Ontology (GO) - Biological Process for TNFRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA --
GO:0007165 signal transduction TAS 10192335
GO:0007275 multicellular organism development IBA --
GO:0032496 response to lipopolysaccharide IBA --
GO:0033209 tumor necrosis factor-mediated signaling pathway IBA --
genes like me logo Genes that share ontologies with TNFRSF8: view

No data available for SIGNOR curated interactions for TNFRSF8 Gene

Drugs & Compounds for TNFRSF8 Gene

Products:

  1. Drug

(16) Drugs for TNFRSF8 Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
brentuximab vedotin Approved Pharma Target, binder 0
Adcetris Approved August 2011 Pharma 0
CD30 ligand Pharma 0
AFM13 Pharma 0
brentuximab Pharma antibody, inhibitor Therapeutic Antibodies 0

(6) Additional Compounds for TNFRSF8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF8: view

Transcripts for TNFRSF8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for TNFRSF8 Gene

(7) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFRSF8 Gene

Tumor necrosis factor receptor superfamily, member 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF8 Gene

No ASD Table

Relevant External Links for TNFRSF8 Gene

GeneLoc Exon Structure for
TNFRSF8
ECgene alternative splicing isoforms for
TNFRSF8

Expression for TNFRSF8 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for TNFRSF8 Gene

mRNA expression in normal human tissues for TNFRSF8 Gene
mRNA expression by BioGPS for TNFRSF8 GenemRNA expression by GTEx for TNFRSF8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF8 Gene

This gene is overexpressed in Whole Blood (x6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNFRSF8 Gene



SOURCE GeneReport for Unigene cluster for TNFRSF8 Gene Hs.1314

genes like me logo Genes that share expression patterns with TNFRSF8: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TNFRSF8 Gene

Orthologs for TNFRSF8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia TNFRSF8 35
  • 77.39 (n)
  • 65.9 (a)
TNFRSF8 36
  • 66 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia TNFRSF8 35
  • 76.9 (n)
  • 61.62 (a)
TNFRSF8 36
  • 60 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Tnfrsf8 35
  • 71 (n)
  • 59.54 (a)
Tnfrsf8 16
Tnfrsf8 36
  • 57 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia TNFRSF8 35
  • 98.83 (n)
  • 98.34 (a)
TNFRSF8 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Tnfrsf8 35
  • 67.16 (n)
  • 54.85 (a)
chicken
(Gallus gallus)
 Aves TNFRSF8 35
  • 54.05 (n)
  • 46.43 (a)
TNFRSF8 36
  • 31 (a)
 OneToOne
Species with no ortholog for TNFRSF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFRSF8 Gene

ENSEMBL:
Gene Tree for TNFRSF8 (if available)
TreeFam:
Gene Tree for TNFRSF8 (if available)

Paralogs for TNFRSF8 Gene

No data available for Paralogs for TNFRSF8 Gene

Variants for TNFRSF8 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_018753 -
rs2230625 - 12,126,001(+) GCTCC(A/G)GCGCC reference, missense
rs2230624 - 12,115,601(+) GCCAT(A/G/T)TGCAT reference, missense
rs1763642 - 12,115,672(-) GGCAC(A/G)GGAGT reference, missense
rs2275170 - 12,115,723(-) CTGGG(A/G)CTTGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF8 Gene

Variant ID Type Subtype PubMed ID
nsv469830 CNV Complex 16826518
nsv466060 CNV Loss 19166990
esv2662914 CNV Deletion 23128226
nsv525898 CNV Loss 19592680
esv1290308 CNV Deletion 17803354
nsv508891 CNV Insertion 20534489
esv2670946 CNV Deletion 23128226
esv2743796 CNV Deletion 23290073
nsv820293 CNV Loss 19587683

Variation tolerance for TNFRSF8 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TNFRSF8 Gene

Disorders for TNFRSF8 Gene

MalaCards: The human disease database

(58) MalaCards diseases for TNFRSF8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
anaplastic large cell lymphoma
  • alcl
lymphomatoid papulosis
  • lyp
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
hodgkin lymphoma
  • hodgkin's lymphoma
reticulosarcoma
  • lymphoma, non-hodgkin
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFRSF8

Genetic Association Database (GAD)
TNFRSF8
Human Genome Epidemiology (HuGE) Navigator
TNFRSF8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFRSF8
genes like me logo Genes that share disorders with TNFRSF8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF8 Gene

Publications for TNFRSF8 Gene

  1. Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease. (PMID: 1310894) Duerkop H. … Stein H. (Cell 1992) 2 3 4 67
  2. Altered expression of the lymphocyte activation antigen CD30 in active celiac disease. (PMID: 20166880) Periolo N. … CherA+avsky A.C. (Autoimmunity 2010) 3 23
  3. Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma. (PMID: 17965727) Watanabe M. … Horie R. (Lab. Invest. 2008) 3 23
  4. CD30 expression utilization for the accuracy of classical Hodgkin's lymphoma staging. (PMID: 17106517) Flangea C. … Dogaru C. (Rom J Morphol Embryol 2006) 3 23
  5. Human embryonal epithelial cells of the developing small intestinal crypts can express the Hodgkin-cell associated antigen Ki-1 (CD30) in spontaneous abortions during the first trimester of gestation. (PMID: 15644135) Tamiolakis D. … Papadopoulos N. (Theor Biol Med Model 2005) 3 23

Products for TNFRSF8 Gene

Sources for TNFRSF8 Gene

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