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TNFRSF8 Gene

protein-coding GIFtS: 66
GCID: GC01P012123

Tumor Necrosis Factor Receptor Superfamily, Member 8

(Previous symbols: CD30, D1S166E)

Pneumococci & Pneumococcal Diseases Congress

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 8¹ ²		Ki-1 Antigen² ³
CD30¹ ² ³ ⁵		Ki-1²
D1S166E¹ ² ³ ⁵		Cytokine Receptor CD30²
Lymphocyte Activation Antigen CD30² ³		Tumor Necrosis Factor Receptor Superfamily Member 8²
CD30L Receptor² ³		CD30 Antigen³

External Ids:	HGNC: 11923¹	Entrez Gene: 943²	Ensembl: ENSG00000120949⁷	OMIM: 153243⁵	UniProtKB: P28908³

Export aliases for TNFRSF8 gene to outside databases

Previous GC identifers: GC01P012187 GC01P011968 GC01P011732 GC01P011832 GC01P012057 GC01P011277

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFRSF8 Gene:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by

activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the

signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of

apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and

protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding

distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFRSF8 Gene:

TNFRSF8 (tumor necrosis factor receptor superfamily, member 8) is a protein-coding gene. Diseases associated with TNFRSF8 include pityriasis lichenoides et varioliformis acuta, and splenic abscess. GO annotations related to this gene include transmembrane signaling receptor activity and tumor necrosis factor-activated receptor activity.

UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908

Function: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of

activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B

Gene Wiki entry for TNFRSF8 (CD30) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000001.11 NT_032977.10 NC_018912.2

Regulatory elements:

Regulatory transcription factor binding sites in the TNFRSF8 gene promoter:
STAT5B p53 STAT1beta STAT5A NF-E2 p45 STAT1alpha STAT2 STAT3 NF-E2 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF8 promoter sequence

Search Chromatin IP Primers for TNFRSF8

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36

TNFRSF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF8 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P012123: view genomic region (about GC identifiers)

Start:	12,123,434 bp from pter	End:	12,204,264 bp from pter
Size:	80,831 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 8 precursor

Size: 595 amino acids; 63747 Da

Subunit: Interacts with TRAF1, TRAF2, TRAF3 and TRAF5

Miscellaneous: Most specific Hodgkin disease associated antigen

1 PDB 3D structure from and Proteopedia for TNFRSF8:

1D01 (3D)

Secondary accessions: B1AN79 Q6P4D9

Alternative initiation: 2 isoforms: P28908-1 P28908-2

Explore the universe of human proteins at neXtProt for TNFRSF8: NX_P28908

Explore proteomics data for TNFRSF8 at MOPED

Post-translational modifications:

Phosphorylated on serine and tyrosine residues¹

Glycosylation² at Asn101, Ser206, Thr209, Asn276

Modification sites at PhosphoSitePlus

See TNFRSF8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001234.3 NP_001268359.2

ENSEMBL proteins:

ENSP00000263932 ENSP00000421938 ENSP00000398337 ENSP00000390650

TNFRSF8 Human Recombinant Protein Products:

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TNFRSF8 Antibody Products:

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TNFRSF8 Assay Products:

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	GenScript Custom Assay Services for TNFRSF8
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for TNFRSF8 Cloud-Clone Corp. CLIAs for TNFRSF8

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

CD: CD molecules

TNFRSF: Tumor necrosis factor receptor superfamily

IUPHAR Guide to PHARMACOLOGY protein family classification: CD30

Tumour necrosis factor (TNF) receptor family

2 InterPro protein domains:

IPR001368 TNFR/NGFR_Cys_rich_reg

IPR020416 TNFR_8

Graphical View of Domain Structure for InterPro Entry P28908

ProtoNet protein and cluster: P28908

1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908

Similarity: Contains 6 TNFR-Cys repeats

TNFRSF8 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: TNR8_HUMAN, P28908

Function: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of

activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B

Genatlas biochemistry entry for TNFRSF8:

tumor necrosis factor receptor superfamily,member 8,cell differentiation antigen CD30 (Ki-1),lymphoid

activating,identified by monoclonal antibodies HRS-1,Ki-1

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane signaling receptor activity	TAS	1310894
GO:0005031	tumor necrosis factor-activated receptor activity	RCA	19641626
GO:0005515	protein binding	--	--

TNFRSF8 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for TNFRSF8:

Decreased Hepatitis C virus re

Increased HPV18 LCR reporter a

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tnfrsf8):

hematopoietic system

immune system

TNFRSF8 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Tnfrsf8^tm1Mak for TNFRSF8

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFRSF8

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNFRSF8

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF8

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF8

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		hsa-miR-3679-3p hsa-miR-203 hsa-miR-623 hsa-miR-502-5p hsa-miR-211 hsa-miR-3922-3p hsa-miR-2355-5p hsa-miR-149

		SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF8 3' UTR sequence

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Gene Editing
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		GenScript: all cDNA clones in your preferred vector (see all 2): TNFRSF8 (NM_001243)
		Sino Biological Human cDNA Clone for TNFRSF8
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TNFRSF8
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF8

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

TNR8_HUMAN, P28908: Isoform Long: Cell membrane; Single-pass type I membrane protein

TNR8_HUMAN, P28908: Isoform Short: Cytoplasm

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5
extracellular	2
cytoskeleton	1
lysosome	1
nucleus	1

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Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral component of membrane	IEA	--
GO:0070062	extracellular vesicular exosome	IDA	--

TNFRSF8 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TNFRSF8 About (see all 8)

See pathways by source

SuperPath

Contained pathways About

TNF Signaling

	TNF Signaling	0.50			TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions	0.49
	Death Receptor Signaling	0.50			NF-kB (NFkB) Pathway	0.46

PEDF Induced Signaling

STAT3 Pathway

0.47

Cytokine-cytokine receptor interaction

0.43

Akt Signaling

	Akt Signaling	0.60			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

PAK Pathway

Antioxidant Action of Vitamin-C

0.56

ERK Signaling

Molecular Mechanisms of Cancer

0.51

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for TNFRSF8

TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF8 (see all 7)

	STAT3 Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	p38 Signaling
	Akt Signaling

1 GeneGo (Thomson Reuters) Pathway for TNFRSF8

Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

1 BioSystems Pathway for TNFRSF8

TNF-alpha/NF-kB Signaling Pathway

3 Sino Biological Pathways for TNFRSF8

	TNF Signaling
	Death Receptor Signaling
	NF-kB (NFkB) Pathway

1 Kegg Pathway (Kegg details for TNFRSF8):

Cytokine-cytokine receptor interaction

TNFRSF8 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including TNFRSF8 (see all 8):

Cell Surface Markers in human mouse rat

Th1/Th2 Response in human mouse rat

TNF Ligands & Receptors in human mouse rat

Apoptosis 384HT in human mouse rat

T-Cell Anergy & Immune Tolerance in human mouse rat

Interactions:

GeneGlobe Interaction Network for TNFRSF8

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

Selected Interacting proteins for TNFRSF8 (P28908³ ENSP00000263932⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRAF5	O00463³, ENSP00000261464⁴	I2D: score=4 STRING: ENSP00000261464
TDP2	O95551³, ENSP00000367440⁴	I2D: score=3 STRING: ENSP00000367440
TNFSF8	P32971³, ENSP00000223795⁴	I2D: score=2 STRING: ENSP00000223795
ALK	Q9UM73³, ENSP00000373700⁴	I2D: score=1 STRING: ENSP00000373700
TRAF2	Q12933³, ENSP00000247668⁴	I2D: score=4 STRING: ENSP00000247668

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Gene Ontology (GO): Selected biological process terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	10192335
GO:0008285	negative regulation of cell proliferation	TAS	10192335
GO:0033209	tumor necrosis factor-mediated signaling pathway	RCA	19641626
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	IDA	16108830
GO:0043065	positive regulation of apoptotic process	IDA	16108830

TNFRSF8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for TNFRSF8 (TNR8)

1 IUPHAR Ligand for TNFRSF8 (CD30) About this table

Ligand	Type	Action	Affinity	Pubmed IDs
CD30 ligand	None	None		--

Selected Novoseek inferred chemical compound relationships for TNFRSF8 gene (see all 14) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
[alcl]	88.6	33	17965727 (5), 16140928 (3), 12754742 (2), 8055109 (1) (see all 15)
saporin	55	2	7517259 (1), 8903477 (1)
paraffin	49.7	7	7745117 (2), 8912826 (1), 11866962 (1), 12475440 (1) (see all 6)
ricin a	35.2	1	2152774 (1)
ricin	16.1	1	7591211 (1)
calcium	1.64	5	7866279 (1), 7527901 (1), 7869589 (1)
lipid	1.03	5	15034047 (3)
thymidine	0	1	8535215 (1)
tuberculin	0	1	8568238 (1)
threonine	0	1	16879614 (1)

1 PharmGKB related drug/compound annotation for TNFRSF8 gene About this table

Drug/compound	PharmGKB Annotation
brentuximab vedotin

TNFRSF8 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TNFRSF8 gene (3 alternative transcripts):

NM_001243.4 NM_001281430.2 NM_152942.2

Unigene Cluster for TNFRSF8:

Tumor necrosis factor receptor superfamily, member 8

Hs.1314 [show with all ESTs]

Unigene Representative Sequence: NM_001243

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000263932(uc001atq.3 uc010obc.2) ENST00000514649 ENST00000413146(uc001atr.3 uc001ats.3)

ENST00000479933 ENST00000417814

miRNA Products:		Block miRNA regulation of human, mouse, rat TNFRSF8 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TNFRSF8 (see all 12):
		hsa-miR-3679-3p hsa-miR-203 hsa-miR-623 hsa-miR-502-5p hsa-miR-211 hsa-miR-3922-3p hsa-miR-2355-5p hsa-miR-149

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		QuantiFast Probe-based Assays in human, mouse, rat TNFRSF8

Additional mRNA sequence:

BC063482.1 BC073839.1 BC136400.1 BC141804.1 BC171762.1 D86042.1 M83554.1 S75768.1

3 DOTS entries:

DT.310731 DT.91720897 DT.95153621

22 AceView cDNA sequences:

NM_001243 BC063482 NM_152942 BX110183 BF591056 AA047161 BC073839 BU927609

BV199006 M83554 D86042 BE877671 AA310772 BI909097 AA147594 AI203419

BP430908 AI699969 BI908989 AA928635 BG495230 AA047162

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TNFRSF8 expression in normal human tissues (normalized intensities) TNFRSF8 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTTCAACAAA

About this image

TNFRSF8 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 3) fully expand


Inner Cell Mass (Early Embryonic Tissues) fully expand to see all 2 entries
Human embryonic stem cells (family)

Pancreas (Endocrine System)
Islets of Langerhans

Ovary (Reproductive System)
Oviduct

TNFRSF8 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TNFRSF8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.1314

Pathway & Disease-focused RT² Profiler PCR Arrays including TNFRSF8 (see all 8):

Cell Surface Markers in human mouse rat

Th1/Th2 Response in human mouse rat

TNF Ligands & Receptors in human mouse rat

Apoptosis 384HT in human mouse rat

T-Cell Anergy & Immune Tolerance in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for TNFRSF8
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TNFRSF8
		QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF8
		QuantiFast Probe-based Assays in human, mouse, rat TNFRSF8

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF8 gene from 6 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
chimpanzee (Pan troglodytes)	Mammalia	TNFRSF8¹	tumor necrosis factor receptor superfamily, member more	98.83(n) 98.34(a)	457960 XM_514397.3 XP_514397.3
mouse (Mus musculus)	Mammalia	Tnfrsf8^{1 , 5}	tumor necrosis factor receptor superfamily, member more^{1, 5}	71(n)¹ 59.54(a)¹	4 (78.17 cM)⁵ 21941¹ NM_009401.2¹ NP_033427.1¹ 145267137⁵
rat (Rattus norvegicus)	Mammalia	Tnfrsf8¹	tumor necrosis factor receptor superfamily, member more	67.16(n) 54.85(a)	25069 NM_019135.1 NP_062008.1
cow (Bos taurus)	Mammalia	TNFRSF8¹	tumor necrosis factor receptor superfamily, member more	77.39(n) 65.9(a)	614780 XM_002694054.2 XP_002694100.2
dog (Canis familiaris)	Mammalia	TNFRSF8¹	tumor necrosis factor receptor superfamily, member more	76.9(n) 61.62(a)	487438 XM_005617983.1 XP_005618040.1
chicken (Gallus gallus)	Aves	TNFRSF8¹	tumor necrosis factor receptor superfamily, member more	54.05(n) 46.43(a)	395090 NM_204444.1 NP_989775.1

Species with no ortholog for TNFRSF8

ENSEMBL Gene Tree for TNFRSF8 (if available)
TreeFam Gene Tree for TNFRSF8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113662668^1,2	C	--	12122309(+)	`CTGCTCATC/- CATCC`	1	--	us2k¹		1		CSA	2
rs9702005^1,2	A	--	12122332(+)	`atccaC/Tctatg`	1	--	us2k¹		0	--	--	--	--
rs142444137^1,2	C	--	12127960(+)	`GGGGC-/GGGGGG`	1	--	int¹		0	--	--	--	--
rs35249351^1,2	C	--	12130203(+)	`GGGGG-/GCTGGG`	1	--	int¹		0	--	--	--	--
rs61206685^1,2	C	--	12130219(+)	`TTGGG-/GGGAGCAG`	1	--	int¹		0	--	--	--	--
rs5772483^1,2	C	--	12137926(+)	`TTTGGT/-TTTTT`	1	--	int¹ trp³		2		NA CSA	4
rs145394273^1,2		--	12139785(+)	`ACCTCA/GGCCTC`	1	--	us2k¹		0	--	--	--	--
rs76011809^1,2	F	--	12139822(+)	`GCCATA/GTCACC`	1	--	us2k¹		0	--	--	--	--
rs116783306^1,2	C,F	--	12139888(+)	`TCTTGC/TGTTCC`	1	--	us2k¹		1		WA	118
rs142383347^1,2		--	12140045(+)	`AAGGGA/GCATGA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TNFRSF8 (12123434 - 12204264 bp)

Structural Variations
Database of Genomic Variants (DGV) 9 variations for TNFRSF8: About this table

Variant ID	Type	Subtype	PubMed ID
esv2662914	CNV	Deletion	23128226
esv1290308	CNV	Deletion	17803354
esv2670946	CNV	Deletion	23128226
esv2743796	CNV	Deletion	23290073
nsv508891	CNV	Insertion	20534489
nsv466060	CNV	Loss	19166990
nsv820293	CNV	Loss	19587683
nsv525898	CNV	Loss	19592680
nsv469830	CNV	Complex	16826518

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 153243 OMIM disorders: --

Selected diseases for TNFRSF8 (see all 113): About MalaCards

pityriasis lichenoides et varioliformis acuta splenic abscess interdigitating dendritic cell sarcoma pityriasis lichenoides

aggressive systemic mastocytosis composite lymphoma marek disease lymphoepithelioma-like carcinoma

intravascular large b-cell lymphoma lymphosarcoma anaplastic large cell lymphoma mast-cell leukemia

lymphomatoid papulosis reticulosarcoma malignant histiocytosis panniculitis

mycosis fungoides nodular lymphocyte predominant hodgkin lymphoma primary mediastinal large b-cell lymphoma cutaneous leishmaniasis

3 diseases from the University of Copenhagen DISEASES database for TNFRSF8:

Reticulosarcoma Lymphoma Malignant histiocytosis

TNFRSF8 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

Selected Novoseek inferred disease relationships for TNFRSF8 gene (see all 75) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
anaplastic large cell lymphoma	95.2	70	8183550 (4), 8960041 (2), 12754742 (2), 17965727 (2) (see all 55)
hodgkin disease	87.9	79	11004694 (2), 12754742 (2), 12875982 (2), 9209650 (2) (see all 67)
lymphomatoid papulosis	87.3	14	11121138 (2), 15894695 (2), 1344811 (1), 10556192 (1) (see all 7)
lymphoma large cell	84.2	20	11729213 (2), 1335094 (1), 11891807 (1), 8390600 (1) (see all 15)
lymphoma	79.9	72	11594583 (3), 1330287 (3), 19131793 (2), 10628334 (2) (see all 52)
lymphoma pleomorphic	79.2	1	10672058 (1)
lymphoma t-cell peripheral	74	4	7982672 (1), 1652981 (1), 8513200 (1), 12645345 (1)
lymphoma non-hodgkins	71.9	23	8055109 (2), 7982672 (1), 7564510 (1), 10793083 (1) (see all 22)
lymphoma t-cell	71.5	14	1659246 (1), 12692428 (1), 1509528 (1), 15328201 (1) (see all 13)
lymphoproliferative disorders	69.9	7	15894695 (3), 10793083 (1), 17320171 (1), 16882190 (1) (see all 5)

Genetic Association Database (GAD): TNFRSF8
Human Genome Epidemiology (HuGE) Navigator: TNFRSF8 (10 documents)

Export disorders for TNFRSF8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TNFRSF8 gene, integrated from 10 sources (see all 468):
(articles sorted by number of sources associating them with TNFRSF8)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease. (PubMed id 1310894)^{1, 2, 3} Duerkop H.... Stein H. (Cell 1992)
Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the CD30 antigen from different sources. (PubMed id 7527901)^{1, 2, 9} Jung W....Pfreundschuh M. (Mol. Immunol. 1994)
Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population. (PubMed id 11960307)^{1, 4, 9} Ahmed S....Hara T. (Genes Immun. 2002)
Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). (PubMed id 9511754)^{1, 2, 9} Mizushima S.... Inoue J. (Gene 1998)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)^{1, 4} Lee K.M....Lan Q. (Am. J. Hematol. 2010)
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)^{1, 4} Hosgood H.D....Lan Q. (Occup Environ Med 2009)
Prognostic values of soluble CD30 and CD30 gene polymorphisms in heart transplantation. (PubMed id 16641601)^{1, 4} Frisaldi E....Amoroso A. (Transplantation 2006)
Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PubMed id 15301860)^{1, 4} Cho S.M....Lee J.K. (Hum. Immunol. 2004)
Distribution of human CD30 gene promoter microsatellite alleles in healthy and human immunodeficiency virus-1 infected populations. (PubMed id 12648280)^{1, 4} McIntyre M.Q....Abraham L.J. (Eur. J. Immunogenet. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 943	HGNC: 11923	AceView: TNFRSF8	Ensembl:ENSG00000120949	euGenes: HUgn943
ECgene: TNFRSF8	Kegg: 943	H-InvDB: TNFRSF8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TNFRSF8	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFRSF8	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/tnfrsf8/

Intellectual Property for TNFRSF8 gene
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Patent Information for TNFRSF8 gene:
Search GeneIP for patents involving TNFRSF8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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TNFRSF8 Gene

Tumor Necrosis Factor Receptor Superfamily, Member 8

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TNFRSF8 Gene

Tumor Necrosis Factor Receptor Superfamily, Member 8

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