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Aliases for TNFRSF8 Gene

Aliases for TNFRSF8 Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 8 2 3
  • Lymphocyte Activation Antigen CD30 3 4
  • CD30L Receptor 3 4
  • Ki-1 Antigen 3 4
  • D1S166E 3 4
  • CD30 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 8 3
  • Cytokine Receptor CD30 3
  • Ki-1 Antigen) 6
  • CD30 Antigen 4
  • Ki-1 3

External Ids for TNFRSF8 Gene

Previous HGNC Symbols for TNFRSF8 Gene

  • CD30
  • D1S166E

Previous GeneCards Identifiers for TNFRSF8 Gene

  • GC01P012187
  • GC01P011968
  • GC01P011732
  • GC01P011832
  • GC01P012057
  • GC01P011277

Summaries for TNFRSF8 Gene

Entrez Gene Summary for TNFRSF8 Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF8 Gene

TNFRSF8 (Tumor Necrosis Factor Receptor Superfamily, Member 8) is a Protein Coding gene. Diseases associated with TNFRSF8 include pityriasis lichenoides et varioliformis acuta and splenic abscess. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include transmembrane signaling receptor activity and tumor necrosis factor-activated receptor activity.

UniProtKB/Swiss-Prot for TNFRSF8 Gene

  • Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B

Gene Wiki entry for TNFRSF8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF8 Gene

Genomics for TNFRSF8 Gene

Regulatory Elements for TNFRSF8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNFRSF8 Gene

12,063,377 bp from pter
12,144,207 bp from pter
80,831 bases
Plus strand

Genomic View for TNFRSF8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF8 Gene

Proteins for TNFRSF8 Gene

  • Protein details for TNFRSF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 8
    Protein Accession:
    Secondary Accessions:
    • B1AN79
    • B9EGD9
    • D3YTD8
    • Q6P4D9

    Protein attributes for TNFRSF8 Gene

    595 amino acids
    Molecular mass:
    63747 Da
    Quaternary structure:
    • Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.
    • Most specific Hodgkin disease associated antigen

    Three dimensional structures from OCA and Proteopedia for TNFRSF8 Gene

    Alternative splice isoforms for TNFRSF8 Gene


neXtProt entry for TNFRSF8 Gene

Proteomics data for TNFRSF8 Gene at MOPED

Post-translational modifications for TNFRSF8 Gene

  • Phosphorylated on serine and tyrosine residues
  • Glycosylation at Asn101, Ser206, Thr209, and Asn276
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF8 Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF8 (CD30/TNFRSF8)

Protein Products

  • Enzo Life Sciences proteins for TNFRSF8
  • Cloud-Clone Corp. Proteins for TNFRSF8

No data available for DME Specific Peptides for TNFRSF8 Gene

Domains for TNFRSF8 Gene

Gene Families for TNFRSF8 Gene

Protein Domains for TNFRSF8 Gene

Suggested Antigen Peptide Sequences for TNFRSF8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 TNFR-Cys repeats.
  • Contains 6 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF8: view

Function for TNFRSF8 Gene

Molecular function for TNFRSF8 Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 8,cell differentiation antigen CD30 (Ki-1),lymphoid activating,identified by monoclonal antibodies HRS-1,Ki-1
UniProtKB/Swiss-Prot Function:
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B

Gene Ontology (GO) - Molecular Function for TNFRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TNFRSF8: view

Phenotypes for TNFRSF8 Gene

genes like me logo Genes that share phenotypes with TNFRSF8: view

Animal Models for TNFRSF8 Gene

MGI Knock Outs for TNFRSF8:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for TNFRSF8 Gene

Localization for TNFRSF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF8 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cytoplasm.

Subcellular locations from

Jensen Localization Image for TNFRSF8 Gene COMPARTMENTS Subcellular localization image for TNFRSF8 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TNFRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with TNFRSF8: view

Pathways for TNFRSF8 Gene

genes like me logo Genes that share pathways with TNFRSF8: view

Pathways by source for TNFRSF8 Gene

1 KEGG pathway for TNFRSF8 Gene
1 GeneGo (Thomson Reuters) pathway for TNFRSF8 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for TNFRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0008285 negative regulation of cell proliferation TAS 10192335
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process IDA 16108830
GO:0043065 positive regulation of apoptotic process IDA 16108830
GO:0045556 positive regulation of TRAIL biosynthetic process IDA 16108830
genes like me logo Genes that share ontologies with TNFRSF8: view

Drugs for TNFRSF8 Gene

(1) Drugbank Compounds for TNFRSF8 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Brentuximab vedotin
  • cAC10-vcMMAE
914088-09-8 Target binder approved

(1) IUPHAR Ligand for TNFRSF8 Gene

Ligand Type Action Affinity Pubmed IDs
CD30 ligand None None

(14) Novoseek inferred chemical compound relationships for TNFRSF8 Gene

Compound -log(P) Hits PubMed IDs
[alcl] 88.6 22
saporin 55 2
paraffin 49.7 7
ricin a 35.2 1
ricin 16.1 1

(1) PharmGKB related drug/compound annotations for TNFRSF8 Gene

Drug/compound Annotation
brentuximab vedotin DrugLabel
genes like me logo Genes that share compounds with TNFRSF8: view

Transcripts for TNFRSF8 Gene

Unigene Clusters for TNFRSF8 Gene

Tumor necrosis factor receptor superfamily, member 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF8 Gene

No ASD Table

Relevant External Links for TNFRSF8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF8 Gene

mRNA expression in normal human tissues for TNFRSF8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF8 Gene

This gene is overexpressed in Whole Blood (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNFRSF8 Gene

SOURCE GeneReport for Unigene cluster for TNFRSF8 Gene Hs.1314

genes like me logo Genes that share expressions with TNFRSF8: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for TNFRSF8 Gene

Orthologs for TNFRSF8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNFRSF8 35
  • 77.39 (n)
  • 65.9 (a)
  • 66 (a)
(Canis familiaris)
Mammalia TNFRSF8 35
  • 76.9 (n)
  • 61.62 (a)
  • 60 (a)
(Mus musculus)
Mammalia Tnfrsf8 35
  • 71 (n)
  • 59.54 (a)
Tnfrsf8 16
Tnfrsf8 36
  • 57 (a)
(Pan troglodytes)
Mammalia TNFRSF8 35
  • 98.83 (n)
  • 98.34 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tnfrsf8 35
  • 67.16 (n)
  • 54.85 (a)
(Gallus gallus)
Aves TNFRSF8 35
  • 54.05 (n)
  • 46.43 (a)
  • 31 (a)
Species with no ortholog for TNFRSF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFRSF8 Gene

Gene Tree for TNFRSF8 (if available)
Gene Tree for TNFRSF8 (if available)

Paralogs for TNFRSF8 Gene

No data available for Paralogs for TNFRSF8 Gene

Variants for TNFRSF8 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs474703 -- 12,093,601(-) atagc(A/G)ccact intron-variant
rs476488 -- 12,138,240(+) AGGAG(C/T)GGTGC synonymous-codon, reference
rs481226 -- 12,131,040(+) CTTTC(C/T)ATTCA intron-variant
rs482170 -- 12,131,143(+) aaata(G/T)tttaa intron-variant
rs488733 -- 12,125,278(+) AGATC(C/T)AGata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF8 Gene

Variant ID Type Subtype PubMed ID
nsv469830 CNV Complex 16826518
nsv466060 CNV Loss 19166990
esv2662914 CNV Deletion 23128226
nsv525898 CNV Loss 19592680
esv1290308 CNV Deletion 17803354
nsv508891 CNV Insertion 20534489
esv2670946 CNV Deletion 23128226
esv2743796 CNV Deletion 23290073
nsv820293 CNV Loss 19587683

Relevant External Links for TNFRSF8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF8 Gene

Disorders for TNFRSF8 Gene

(3) University of Copenhagen DISEASES for TNFRSF8 Gene

(75) Novoseek inferred disease relationships for TNFRSF8 Gene

Disease -log(P) Hits PubMed IDs
anaplastic large cell lymphoma 95.2 65
hodgkin disease 87.9 77
lymphomatoid papulosis 87.3 9
lymphoma large cell 84.2 16
lymphoma 79.9 60

Relevant External Links for TNFRSF8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TNFRSF8: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for TNFRSF8 Gene

Publications for TNFRSF8 Gene

  1. Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). (PMID: 9511754) Mizushima S. … Inoue J. (Gene 1998) 3 4 23
  2. Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the CD30 antigen from different sources. (PMID: 7527901) Jung W. … Pfreundschuh M. (Mol. Immunol. 1994) 3 4 23
  3. Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population. (PMID: 11960307) Ahmed S. … Hara T. (Genes Immun. 2002) 3 23 48
  4. Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease. (PMID: 1310894) Duerkop H. … Stein H. (Cell 1992) 2 3 4
  5. T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors. (PMID: 8627180) Lee S.Y. … Choi Y. (J. Exp. Med. 1996) 3 4

Products for TNFRSF8 Gene

Sources for TNFRSF8 Gene

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