Aliases for TNFRSF8 Gene
External Ids for TNFRSF8 Gene
Previous HGNC Symbols for TNFRSF8 Gene
Previous GeneCards Identifiers for TNFRSF8 Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF8 Gene
TNFRSF8 (TNF Receptor Superfamily Member 8) is a Protein Coding gene. Diseases associated with TNFRSF8 include Anaplastic Large Cell Lymphoma and Malignant Histiocytosis. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Akt Signaling. GO annotations related to this gene include transmembrane signaling receptor activity.
UniProtKB/Swiss-Prot for TNFRSF8 Gene
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.