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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNFRSF8 Gene

protein-coding   GIFtS: 66
GCID: GC01P012123

Tumor Necrosis Factor Receptor Superfamily, Member 8


(Previous symbols: CD30, D1S166E)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 81 2     Ki-1 Antigen2 3
CD301 2 3 5     Ki-12
D1S166E1 2 3 5     Cytokine Receptor CD302
Lymphocyte Activation Antigen CD302 3     Tumor Necrosis Factor Receptor Superfamily Member 82
CD30L Receptor2 3     CD30 Antigen3

External Ids:    HGNC: 119231   Entrez Gene: 9432   Ensembl: ENSG000001209497   OMIM: 1532435   UniProtKB: P289083   

Export aliases for TNFRSF8 gene to outside databases

Previous GC identifers: GC01P012187 GC01P011968 GC01P011732 GC01P011832 GC01P012057 GC01P011277


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF8 Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by
activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the
signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of
apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and
protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding
distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFRSF8 Gene: 
TNFRSF8 (tumor necrosis factor receptor superfamily, member 8) is a protein-coding gene. Diseases associated with TNFRSF8 include splenic abscess, and pityriasis lichenoides et varioliformis acuta, and among its related super-pathways are TNF Signaling and STAT3 Pathway. GO annotations related to this gene include transmembrane signaling receptor activity and tumor necrosis factor-activated receptor activity.

UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908
Function: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of
activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B

Gene Wiki entry for TNFRSF8 (CD30) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNFRSF8 gene promoter:
         STAT5B   p53   STAT1beta   STAT5A   NF-E2 p45   STAT1alpha   STAT2   STAT3   NF-E2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF8 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNFRSF8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36

TNFRSF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P012123:  view genomic region     (about GC identifiers)

Start:
12,123,434 bp from pter      End:
12,204,264 bp from pter
Size:
80,831 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 8 precursor  
Size: 595 amino acids; 63747 Da
Subunit: Interacts with TRAF1, TRAF2, TRAF3 and TRAF5
Subcellular location: Isoform Long: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform Short: Cytoplasm
Miscellaneous: Most specific Hodgkin disease associated antigen
1 PDB 3D structure from and Proteopedia for TNFRSF8:
1D01 (3D)    
Secondary accessions: B1AN79 Q6P4D9
Alternative initiation: 2 isoforms:  P28908-1   P28908-2   

Explore the universe of human proteins at neXtProt for TNFRSF8: NX_P28908

Explore proteomics data for TNFRSF8 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on serine and tyrosine residues
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P28908

  • TNFRSF8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNFRSF8 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001234.2  NP_001268359.1  

    ENSEMBL proteins: 
     ENSP00000263932   ENSP00000421938   ENSP00000398337   ENSP00000390650  

    Human Recombinant Protein Products for TNFRSF8: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TNFRSF8
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    Sino Biological Recombinant Protein for TNFRSF8
    Sino Biological Cell Lysate for TNFRSF8 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNFRSF8 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    TNFRSF8 for ontologies           About GeneDecksing



    TNFRSF8 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for TNFRSF8 

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    Cloud-Clone Corp. ELISAs for TNFRSF8 
    Cloud-Clone Corp. CLIAs for TNFRSF8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: CD30 
    Tumour necrosis factor (TNF) receptor family

    2 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR020416 TNFR_8

    Graphical View of Domain Structure for InterPro Entry P28908

    ProtoNet protein and cluster: P28908

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908
    Similarity: Contains 6 TNFR-Cys repeats


    TNFRSF8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR8_HUMAN, P28908
    Function: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of
    activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B

         Genatlas biochemistry entry for TNFRSF8:
    tumor necrosis factor receptor superfamily,member 8,cell differentiation antigen CD30 (Ki-1),lymphoid
    activating,identified by monoclonal antibodies HRS-1,Ki-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS1310894
    GO:0005031tumor necrosis factor-activated receptor activity RCA19641626
    GO:0005515protein binding ----
         
    TNFRSF8 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNFRSF8:
     Decreased Hepatitis C virus re  Increased HPV18 LCR reporter a 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tnfrsf8):
     hematopoietic system  immune system 

    TNFRSF8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tnfrsf8tm1Mak for TNFRSF8

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNFRSF8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNFRSF8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF8 

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    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF8 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of TNFRSF8 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNFRSF8 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    5Rho Family GTPases
    Molecular Mechanisms of Cancer0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TNFRSF8
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

    1 R&D Systems Pathway for TNFRSF8
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF8 (see all 7)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling

    1 GeneGo (Thomson Reuters) Pathway for TNFRSF8
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

    1 BioSystems Pathway for TNFRSF8
        TNF-alpha/NF-kB Signaling Pathway

    3 Sino Biological Pathways for TNFRSF8 
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1         Kegg Pathway  (Kegg details for TNFRSF8):
        Cytokine-cytokine receptor interaction


    TNFRSF8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNFRSF8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for TNFRSF8 (P289083 ENSP000002639324) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF5O004633, ENSP000002614644I2D: score=4 STRING: ENSP00000261464
    TDP2O955513, ENSP000003674404I2D: score=3 STRING: ENSP00000367440
    TNFSF8P329713, ENSP000002237954I2D: score=2 STRING: ENSP00000223795
    ALKQ9UM733, ENSP000003737004I2D: score=1 STRING: ENSP00000373700
    TRAF2Q129333, ENSP000002476684I2D: score=4 STRING: ENSP00000247668
    About this table

    Gene Ontology (GO): 7 biological process terms (GO ID links to tree view) (see first 5):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS10192335
    GO:0008285negative regulation of cell proliferation TAS10192335
    GO:0033209tumor necrosis factor-mediated signaling pathway RCA19641626
    GO:0042535positive regulation of tumor necrosis factor biosynthetic process IDA16108830
    GO:0043065positive regulation of apoptotic process IDA16108830
    GO:0045556positive regulation of TRAIL biosynthetic process IDA16108830
    GO:0071260cellular response to mechanical stimulus IEP19593445

    TNFRSF8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TNFRSF8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNFRSF8 (TNR8)

    1 IUPHAR Ligand for TNFRSF8 (CD30)    About this table 
    LigandTypeActionAffinityPubmed IDs
    CD30 ligand
    NoneNone--

    10/14 Novoseek inferred chemical compound relationships for TNFRSF8 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    [alcl] 88.6 33 17965727 (5), 16140928 (3), 12754742 (2), 8055109 (1) (see all 15)
    saporin 55 2 7517259 (1), 8903477 (1)
    paraffin 49.7 7 7745117 (2), 8912826 (1), 11866962 (1), 12475440 (1) (see all 6)
    ricin a 35.2 1 2152774 (1)
    ricin 16.1 1 7591211 (1)
    calcium 1.64 5 7866279 (1), 7527901 (1), 7869589 (1)
    lipid 1.03 5 15034047 (3)
    thymidine 0 1 8535215 (1)
    tuberculin 0 1 8568238 (1)
    threonine 0 1 16879614 (1)

    1 PharmGKB related drug/compound annotation for TNFRSF8 gene    About this table
    Drug/compound PharmGKB Annotation
    brentuximab vedotin

    Search CenterWatch for drugs/clinical trials and news about TNFRSF8 / TNR8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNFRSF8 gene (3 alternative transcripts): 
    NM_001243.3  NM_001281430.1  NM_152942.2  

    Unigene Cluster for TNFRSF8:

    Tumor necrosis factor receptor superfamily, member 8
    Hs.1314  [show with all ESTs]
    Unigene Representative Sequence: NM_001243
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263932(uc001atq.3 uc010obc.2) ENST00000514649 ENST00000413146(uc001atr.3 uc001ats.3)
    ENST00000479933 ENST00000417814

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    Additional mRNA sequence: 

    BC063482.1 BC073839.1 BC136400.1 BC141804.1 BC171762.1 D86042.1 M83554.1 S75768.1 

    3 DOTS entries:

    DT.310731  DT.91720897  DT.95153621 

    22 AceView cDNA sequences:

    BC073839 NM_152942 BF591056 NM_001243 AA047161 BC063482 BX110183 D86042 
    AA310772 M83554 BV199006 BE877671 BU927609 AA147594 BI909097 BI908989 
    BP430908 AI203419 AI699969 AA928635 BG495230 AA047162 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNFRSF8 expression in normal human tissues (normalized intensities)      TNFRSF8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAACAAA
    TNFRSF8 Expression
    About this image


    TNFRSF8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Colon (Gastrointestinal Tract)
             colon ; endothelial cells   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Lower Urinary Tract (Urinary System)
             urinary bladder ; urothelial cells   
     
     Oral Cavity (Gastrointestinal Tract)
             oral mucosa ; squamous epithelial cells   
     
     Pancreas (Endocrine System)
             pancreas ; exocrine glandular cells   

    See TNFRSF8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNFRSF8

    SOURCE GeneReport for Unigene cluster: Hs.1314
        SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF8 (see all 8): 
              Cell Surface Markers in human mouse rat
              Th1/Th2 Response in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF8 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf81 , 5 tumor necrosis factor receptor superfamily, member more1, 5 63.8(n)1
    52.76(a)1
      4 (78.17 cM)5
    219411  NM_009401.21  NP_033427.11 
     1452671375 
    chicken
    (Gallus gallus)
    Aves TNFRSF81 tumor necrosis factor receptor superfamily, member more 49.38(n)
    38.11(a)
      395090  NM_204444.1  NP_989775.1 


    ENSEMBL Gene Tree for TNFRSF8 (if available)
    TreeFam Gene Tree for TNFRSF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2005 SNPs in TNFRSF8 are shown (see all 2005)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0187534
    ----see VAR_0187532 C Y mis40--------
    rs1136626681,2
    C--12122309(+) CTGCTCATC/-  
            
    CATCC
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs97020051,2
    A--12122332(+) atccaC/Tctatg 1 -- us2k10--------
    rs1424441371,2
    C--12127960(+) GGGGC-/GGGGGG 1 -- int10--------
    rs352493511,2
    C--12130203(+) GGGGG-/GCTGGG 1 -- int10--------
    rs612066851,2
    C--12130219(+) TTGGG-/GGGAGCAG 1 -- int10--------
    rs57724831,2
    C--12137926(+) TTTGGT/-TTTTT 1 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs1453942731,2
    --12139785(+) ACCTCA/GGCCTC 1 -- us2k10--------
    rs760118091,2
    F--12139822(+) GCCATA/GTCACC 1 -- us2k10--------
    rs1167833061,2
    C,F--12139888(+) TCTTGC/TGTTCC 1 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for TNFRSF8 (12123434 - 12204264 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TNFRSF8:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662914CNV Deletion23128226
    esv1290308CNV Deletion17803354
    esv2670946CNV Deletion23128226
    esv2743796CNV Deletion23290073
    nsv508891CNV Insertion20534489
    nsv466060CNV Loss19166990
    nsv820293CNV Loss19587683
    nsv525898CNV Loss19592680
    nsv469830CNV Complex16826518

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 153243    OMIM disorders: --

    20/100 diseases for TNFRSF8 (see all 100):    About MalaCards
    splenic abscess    pityriasis lichenoides et varioliformis acuta    interdigitating dendritic cell sarcoma    pityriasis lichenoides
    composite lymphoma    marek disease    intravascular large b-cell lymphoma    lymphoepithelioma-like carcinoma
    lymphosarcoma    anaplastic large cell lymphoma    lymphomatoid papulosis    mast-cell leukemia
    reticulosarcoma    hodgkin's lymphoma    panniculitis    malignant histiocytosis
    cutaneous leishmaniasis    mycosis fungoides    dendritic cell sarcoma    histiocytosis

    3 diseases from the University of Copenhagen DISEASES database for TNFRSF8:
    Reticulosarcoma     Lymphoma     Malignant histiocytosis

    TNFRSF8 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/75 Novoseek inferred disease relationships for TNFRSF8 gene (see all 75)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anaplastic large cell lymphoma 95.2 70 8183550 (4), 8960041 (2), 12754742 (2), 17965727 (2) (see all 55)
    hodgkin disease 87.9 79 11004694 (2), 12754742 (2), 12875982 (2), 9209650 (2) (see all 67)
    lymphomatoid papulosis 87.3 14 11121138 (2), 15894695 (2), 1344811 (1), 10556192 (1) (see all 7)
    lymphoma large cell 84.2 20 11729213 (2), 1335094 (1), 11891807 (1), 8390600 (1) (see all 15)
    lymphoma 79.9 72 11594583 (3), 1330287 (3), 19131793 (2), 10628334 (2) (see all 52)
    lymphoma pleomorphic 79.2 1 10672058 (1)
    lymphoma t-cell peripheral 74 4 7982672 (1), 1652981 (1), 8513200 (1), 12645345 (1)
    lymphoma non-hodgkins 71.9 23 8055109 (2), 7982672 (1), 7564510 (1), 10793083 (1) (see all 22)
    lymphoma t-cell 71.5 14 1659246 (1), 12692428 (1), 1509528 (1), 15328201 (1) (see all 13)
    lymphoproliferative disorders 69.9 7 15894695 (3), 10793083 (1), 17320171 (1), 16882190 (1) (see all 5)

    Genetic Association Database (GAD): TNFRSF8
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF8 (10 documents)

    Export disorders for TNFRSF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNFRSF8 gene, integrated from 9 sources (see all 463):
    (articles sorted by number of sources associating them with TNFRSF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease. (PubMed id 1310894)1, 2, 3 Duerkop H.... Stein H. (1992)
    2. Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the CD30 antigen from different sources. (PubMed id 7527901)1, 2, 9 Jung W....Pfreundschuh M. (1994)
    3. Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population. (PubMed id 11960307)1, 4, 9 Ahmed S....Hara T. (2002)
    4. Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). (PubMed id 9511754)1, 2, 9 Mizushima S.... Inoue J. (1998)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    7. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    8. Prognostic values of soluble CD30 and CD30 gene polymorphisms in heart transplantation. (PubMed id 16641601)1, 4 Frisaldi E....Amoroso A. (2006)
    9. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PubMed id 15301860)1, 4 Cho S.M....Lee J.K. (2004)
    10. Distribution of human CD30 gene promoter microsatellite alleles in healthy and human immunodeficiency virus-1 infected populations. (PubMed id 12648280)1, 4 McIntyre M.Q....Abraham L.J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 943 HGNC: 11923 AceView: TNFRSF8 Ensembl:ENSG00000120949 euGenes: HUgn943
    ECgene: TNFRSF8 Kegg: 943 H-InvDB: TNFRSF8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNFRSF8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF8 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf8/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNFRSF8 gene:
    Search GeneIP for patents involving TNFRSF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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