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TNFRSF8 Gene

protein-coding   GIFtS: 66
GCID: GC01P012123

Tumor Necrosis Factor Receptor Superfamily, Member 8


(Previous symbols: CD30, D1S166E)
  See TNFRSF8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 81 2     Ki-1 Antigen2 3
CD301 2 3 5     Ki-12
D1S166E1 2 3 5     Cytokine Receptor CD302
Lymphocyte Activation Antigen CD302 3     Tumor Necrosis Factor Receptor Superfamily Member 82
CD30L Receptor2 3     CD30 Antigen3

External Ids:    HGNC: 119231   Entrez Gene: 9432   Ensembl: ENSG000001209497   OMIM: 1532435   UniProtKB: P289083   

Export aliases for TNFRSF8 gene to outside databases

Previous GC identifers: GC01P012187 GC01P011968 GC01P011732 GC01P011832 GC01P012057 GC01P011277


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TNFRSF8 Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by
activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the
signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of
apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and
protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding
distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNFRSF8 Gene:
TNFRSF8 (tumor necrosis factor receptor superfamily, member 8) is a protein-coding gene. Diseases associated with TNFRSF8 include pityriasis lichenoides et varioliformis acuta, and splenic abscess. GO annotations related to this gene include transmembrane signaling receptor activity and tumor necrosis factor-activated receptor activity.

UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908
Function: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of
activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B

Gene Wiki entry for TNFRSF8 (CD30) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFRSF8 gene promoter:
         STAT5B   p53   STAT1beta   STAT5A   NF-E2 p45   STAT1alpha   STAT2   STAT3   NF-E2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF8 promoter sequence
   Search Chromatin IP Primers for TNFRSF8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36

TNFRSF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P012123:  view genomic region     (about GC identifiers)

Start:
12,123,434 bp from pter      End:
12,204,264 bp from pter
Size:
80,831 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 8 precursor  
Size: 595 amino acids; 63747 Da
Subunit: Interacts with TRAF1, TRAF2, TRAF3 and TRAF5
Miscellaneous: Most specific Hodgkin disease associated antigen
1 PDB 3D structure from and Proteopedia for TNFRSF8:
1D01 (3D)    
Secondary accessions: B1AN79 Q6P4D9
Alternative initiation: 2 isoforms:  P28908-1   P28908-2   

Explore the universe of human proteins at neXtProt for TNFRSF8: NX_P28908

Explore proteomics data for TNFRSF8 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine and tyrosine residues1
  • Glycosylation2 at Asn101, Ser206, Thr209, Asn276
  • Modification sites at PhosphoSitePlus

  • See TNFRSF8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001234.3  NP_001268359.2  

    ENSEMBL proteins: 
     ENSP00000263932   ENSP00000421938   ENSP00000398337   ENSP00000390650  

    TNFRSF8 Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for TNFRSF8
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNFRSF8

     
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    antibodies-online proteins for TNFRSF8 (7 products) 

     
    Search antibodies-online for peptides for TNFRSF8

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    Cloud-Clone Corp. ELISAs for TNFRSF8
    Cloud-Clone Corp. CLIAs for TNFRSF8
    eBioscience ELISAs for TNFRSF8: (see all 5
                        Human sCD30 Instant ELISA 128 tests
    antibodies-online kits for TNFRSF8 (17 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: CD30
    Tumour necrosis factor (TNF) receptor family

    2 InterPro protein domains:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR020416 TNFR_8

    Graphical View of Domain Structure for InterPro Entry P28908

    ProtoNet protein and cluster: P28908

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908
    Similarity: Contains 6 TNFR-Cys repeats


    Find genes that share domains with TNFRSF8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR8_HUMAN, P28908
    Function: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of
    activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B

         Genatlas biochemistry entry for TNFRSF8:
    tumor necrosis factor receptor superfamily,member 8,cell differentiation antigen CD30 (Ki-1),lymphoid
    activating,identified by monoclonal antibodies HRS-1,Ki-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS1310894
    GO:0005031tumor necrosis factor-activated receptor activity RCA19641626
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TNFRSF8           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNFRSF8:
     Decreased Hepatitis C virus re  Increased HPV18 LCR reporter a 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tnfrsf8):
     hematopoietic system  immune system 

    Find genes that share phenotypes with TNFRSF8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tnfrsf8tm1Mak for TNFRSF8

       genOway: Develop your customized and physiologically relevant rodent model for TNFRSF8

    miRNA
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    Block miRNA regulation of human, mouse, rat TNFRSF8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNFRSF8 (see all 12):
    hsa-miR-3679-3p hsa-miR-203 hsa-miR-623 hsa-miR-502-5p hsa-miR-211 hsa-miR-3922-3p hsa-miR-2355-5p hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidTNFRSF8 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNR8_HUMAN, P28908: Isoform Long: Cell membrane; Single-pass type I membrane protein
    TNR8_HUMAN, P28908: Isoform Short: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    lysosome1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with TNFRSF8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNFRSF8 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    5ERK Signaling
    Molecular Mechanisms of Cancer0.51


    Find genes that share SuperPaths with TNFRSF8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFRSF8
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF8 (see all 7)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling

    1 GeneGo (Thomson Reuters) Pathway for TNFRSF8
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

    1 BioSystems Pathway for TNFRSF8
        TNF-alpha/NF-kB Signaling Pathway

    3 Sino Biological Pathways for TNFRSF8
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1 Kegg Pathway  (Kegg details for TNFRSF8):
        Cytokine-cytokine receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF8 (see all 8): 
              Cell Surface Markers in human mouse rat
              Th1/Th2 Response in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFRSF8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for TNFRSF8 (P289083 ENSP000002639324) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF5O004633, ENSP000002614644I2D: score=4 STRING: ENSP00000261464
    TDP2O955513, ENSP000003674404I2D: score=3 STRING: ENSP00000367440
    TNFSF8P329713, ENSP000002237954I2D: score=2 STRING: ENSP00000223795
    ALKQ9UM733, ENSP000003737004I2D: score=1 STRING: ENSP00000373700
    TRAF2Q129333, ENSP000002476684I2D: score=4 STRING: ENSP00000247668
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS10192335
    GO:0008285negative regulation of cell proliferation TAS10192335
    GO:0033209tumor necrosis factor-mediated signaling pathway RCA19641626
    GO:0042535positive regulation of tumor necrosis factor biosynthetic process IDA16108830
    GO:0043065positive regulation of apoptotic process IDA16108830

    Find genes that share ontologies with TNFRSF8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFRSF8 (TNR8)

    1 IUPHAR Ligand for TNFRSF8 (CD30)    About this table
    LigandTypeActionAffinityPubmed IDs
    CD30 ligand
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for TNFRSF8 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    [alcl] 88.6 33 17965727 (5), 16140928 (3), 12754742 (2), 8055109 (1), 10786813 (1), 11891807 (1), 15050749 (1), 11097375 (1), 11729213 (1), 8781434 (1), 11908723 (1), 17655697 (1), 8204884 (1), 10757332 (1), 12353136 (1) (see top 4)
    saporin 55 2 7517259 (1), 8903477 (1)
    paraffin 49.7 7 7745117 (2), 8912826 (1), 11866962 (1), 12475440 (1), 18460027 (1), 2370346 (1) (see top 4)
    ricin a 35.2 1 2152774 (1)
    ricin 16.1 1 7591211 (1)
    calcium 1.64 5 7866279 (1), 7527901 (1), 7869589 (1)
    lipid 1.03 5 15034047 (3)
    thymidine 0 1 8535215 (1)
    tuberculin 0 1 8568238 (1)
    threonine 0 1 16879614 (1)

    1 PharmGKB related drug/compound annotation for TNFRSF8 gene    About this table
    Drug/compound PharmGKB Annotation
    brentuximab vedotin



    Find genes that share compounds with TNFRSF8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNFRSF8 gene (3 alternative transcripts): 
    NM_001243.4  NM_001281430.2  NM_152942.2  

    Unigene Cluster for TNFRSF8:

    Tumor necrosis factor receptor superfamily, member 8
    Hs.1314  [show with all ESTs]
    Unigene Representative Sequence: NM_001243
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263932(uc001atq.3 uc010obc.2) ENST00000514649 ENST00000413146(uc001atr.3 uc001ats.3)
    ENST00000479933 ENST00000417814
    miRNA
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    hsa-miR-3679-3p hsa-miR-203 hsa-miR-623 hsa-miR-502-5p hsa-miR-211 hsa-miR-3922-3p hsa-miR-2355-5p hsa-miR-149
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      QuantiFast Probe-based Assays in human, mouse, rat TNFRSF8

    Additional mRNA sequence: 

    BC063482.1 BC073839.1 BC136400.1 BC141804.1 BC171762.1 D86042.1 M83554.1 S75768.1 

    3 DOTS entries:

    DT.310731  DT.91720897  DT.95153621 

    22 AceView cDNA sequences:

    NM_001243 BC063482 NM_152942 BX110183 BF591056 AA047161 BC073839 BU927609 
    BV199006 M83554 D86042 BE877671 AA310772 BI909097 AA147594 AI203419 
    BP430908 AI699969 BI908989 AA928635 BG495230 AA047162 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNFRSF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAACAAA
    TNFRSF8 Expression
    About this image


    TNFRSF8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Ovary (Reproductive System)
             Oviduct
    TNFRSF8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFRSF8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1314
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF8 (see all 8): 
              Cell Surface Markers in human mouse rat
              Th1/Th2 Response in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat TNFRSF8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF8 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnfrsf81 , 5 tumor necrosis factor receptor superfamily, member more1, 5 71(n)1
    59.54(a)1
      4 (78.17 cM)5
    219411  NM_009401.21  NP_033427.11 
     1452671375 
    chicken
    (Gallus gallus)
    Aves TNFRSF81 tumor necrosis factor receptor superfamily, member more 54.05(n)
    46.43(a)
      395090  NM_204444.1  NP_989775.1 


    ENSEMBL Gene Tree for TNFRSF8 (if available)
    TreeFam Gene Tree for TNFRSF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNFRSF8 (see all 2005)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1136626681,2
    C--12122309(+) CTGCTCATC/-  
            
    CATCC
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs97020051,2
    A--12122332(+) atccaC/Tctatg 1 -- us2k10--------
    rs1424441371,2
    C--12127960(+) GGGGC-/GGGGGG 1 -- int10--------
    rs352493511,2
    C--12130203(+) GGGGG-/GCTGGG 1 -- int10--------
    rs612066851,2
    C--12130219(+) TTGGG-/GGGAGCAG 1 -- int10--------
    rs57724831,2
    C--12137926(+) TTTGGT/-TTTTT 1 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs1453942731,2
    --12139785(+) ACCTCA/GGCCTC 1 -- us2k10--------
    rs760118091,2
    F--12139822(+) GCCATA/GTCACC 1 -- us2k10--------
    rs1167833061,2
    C,F--12139888(+) TCTTGC/TGTTCC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1423833471,2
    --12140045(+) AAGGGA/GCATGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TNFRSF8 (12123434 - 12204264 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TNFRSF8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662914CNV Deletion23128226
    esv1290308CNV Deletion17803354
    esv2670946CNV Deletion23128226
    esv2743796CNV Deletion23290073
    nsv508891CNV Insertion20534489
    nsv466060CNV Loss19166990
    nsv820293CNV Loss19587683
    nsv525898CNV Loss19592680
    nsv469830CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNFRSF8
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 153243    OMIM disorders: --

    12 diseases for TNFRSF8:    
    About MalaCards
    pityriasis lichenoides et varioliformis acuta    splenic abscess    pityriasis lichenoides    aggressive systemic mastocytosis
    composite lymphoma    reticulosarcoma    lymphoepithelioma-like carcinoma    intravascular large b-cell lymphoma
    malignant histiocytosis    hodgkin's lymphoma    primary mediastinal large b-cell lymphoma    malaria

    3 diseases from the University of Copenhagen DISEASES database for TNFRSF8:
    Reticulosarcoma     Lymphoma     Malignant histiocytosis

    Find genes that share disorders with TNFRSF8           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TNFRSF8 gene (see all 75)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anaplastic large cell lymphoma 95.2 70 8183550 (4), 8960041 (2), 12754742 (2), 17965727 (2) (see all 55)
    hodgkin disease 87.9 79 11004694 (2), 12754742 (2), 12875982 (2), 9209650 (2) (see all 67)
    lymphomatoid papulosis 87.3 14 11121138 (2), 15894695 (2), 1344811 (1), 10556192 (1) (see all 7)
    lymphoma large cell 84.2 20 11729213 (2), 1335094 (1), 11891807 (1), 8390600 (1) (see all 15)
    lymphoma 79.9 72 11594583 (3), 1330287 (3), 19131793 (2), 10628334 (2) (see all 52)
    lymphoma pleomorphic 79.2 1 10672058 (1)
    lymphoma t-cell peripheral 74 4 7982672 (1), 1652981 (1), 8513200 (1), 12645345 (1)
    lymphoma non-hodgkins 71.9 23 8055109 (2), 7982672 (1), 7564510 (1), 10793083 (1) (see all 22)
    lymphoma t-cell 71.5 14 1659246 (1), 12692428 (1), 1509528 (1), 15328201 (1) (see all 13)
    lymphoproliferative disorders 69.9 7 15894695 (3), 10793083 (1), 17320171 (1), 16882190 (1) (see all 5)

    Genetic Association Database (GAD): TNFRSF8
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF8 (10 documents)

    Export disorders for TNFRSF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNFRSF8 gene, integrated from 10 sources (see all 468):
    (articles sorted by number of sources associating them with TNFRSF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease. (PubMed id 1310894)1, 2, 3 Duerkop H.... Stein H. (Cell 1992)
    2. Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the CD30 antigen from different sources. (PubMed id 7527901)1, 2, 9 Jung W....Pfreundschuh M. (Mol. Immunol. 1994)
    3. Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population. (PubMed id 11960307)1, 4, 9 Ahmed S....Hara T. (Genes Immun. 2002)
    4. Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). (PubMed id 9511754)1, 2, 9 Mizushima S.... Inoue J. (Gene 1998)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    7. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    8. Prognostic values of soluble CD30 and CD30 gene polymorphisms in heart transplantation. (PubMed id 16641601)1, 4 Frisaldi E....Amoroso A. (Transplantation 2006)
    9. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PubMed id 15301860)1, 4 Cho S.M....Lee J.K. (Hum. Immunol. 2004)
    10. Distribution of human CD30 gene promoter microsatellite alleles in healthy and human immunodeficiency virus-1 infected populations. (PubMed id 12648280)1, 4 McIntyre M.Q....Abraham L.J. (Eur. J. Immunogenet. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 943 HGNC: 11923 AceView: TNFRSF8 Ensembl:ENSG00000120949 euGenes: HUgn943
    ECgene: TNFRSF8 Kegg: 943 H-InvDB: TNFRSF8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNFRSF8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF8 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf8/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNFRSF8 gene:
    Search GeneIP for patents involving TNFRSF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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