Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TNFRSF8 Gene

protein-coding GIFtS: 65
GCID: GC01P012123

tumor necrosis factor receptor superfamily, member 8

(Previous symbols: CD30, D1S166E)

Explore 106 diseases affiliated with
TNFRSF8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 8¹ ²		KI-1¹
CD30¹ ² ³ ⁵		Ki-1²
D1S166E¹ ² ³ ⁵		Cytokine Receptor CD30²
Lymphocyte Activation Antigen CD30² ³		Tumor Necrosis Factor Receptor Superfamily Member 8²
CD30L Receptor² ³		CD30 Antigen³
Ki-1 Antigen² ³

External Ids:	HGNC: 11923¹	Entrez Gene: 943²	Ensembl: ENSG00000120949⁷	OMIM: 153243⁵	UniProtKB: P28908³

Export aliases for TNFRSF8 gene to outside databases

Previous GC identifers: GC01P012187 GC01P011968 GC01P011732 GC01P011832 GC01P012057 GC01P011277

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF8:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated,

but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal

transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also

has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against

autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been

reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908

Function: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of

activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B

Gene Wiki entry for TNFRSF8 (CD30)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_021937.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNFRSF8 gene promoter:
STAT5B p53 STAT1beta STAT5A NF-E2 p45 STAT1alpha STAT2 STAT3 NF-E2 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNFRSF8 promoter sequence

Search SABiosciences Chromatin IP Primers for TNFRSF8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36

TNFRSF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF8 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P012123: view genomic region (about GC identifiers)

Start:	12,123,434 bp from pter	End:	12,204,264 bp from pter
Size:	80,831 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 8 precursor

Size: 595 amino acids; 63747 Da

Subunit: Interacts with TRAF1, TRAF2, TRAF3 and TRAF5

Subcellular location: Isoform Long: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform Short: Cytoplasm

Miscellaneous: Most specific Hodgkin disease associated antigen

1 PDB 3D structure from and Proteopedia for TNFRSF8:

1D01 (3D)

Secondary accessions: B1AN79 Q6P4D9

Alternative initiation: 2 isoforms: P28908-1 P28908-2

Explore the universe of human proteins at neXtProt for TNFRSF8: NX_P28908

Post-translational modifications:

Phosphorylated on serine and tyrosine residues¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P28908

TNFRSF8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001234.2 NP_694421.1

ENSEMBL proteins:

ENSP00000263932 ENSP00000421938 ENSP00000398337 ENSP00000390650

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for TNFRSF8 (CD30/TNFRSF8)
	Enzo Life Sciences proteins for TNFRSF8
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TNFRSF8 OriGene Custom Protein Services for TNFRSF8
	GenScript Custom Purified and Recombinant Proteins Services for TNFRSF8
	Novus Biologicals TNFRSF8 Protein Novus Biologicals TNFRSF8 Lysate
	Sino Biological Recombinant Protein for TNFRSF8
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TNFRSF8

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

TNFRSF8 for ontologies About GeneDecksing

TNFRSF8 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TNFRSF8
	R&D Systems Antibodies for TNFRSF8 (CD30/TNFRSF8)
	OriGene Antibodies (see all 6): TNFRSF8 OriGene Custom Antibody Services for TNFRSF8
	GenScript Custom Superior Antibodies Services for TNFRSF8
	Novus Biologicals TNFRSF8 Antibodies
	Abcam antibodies for TNFRSF8
	Uscn Antibodies for TNFRSF8
	ThermoFisher Antibody for TNFRSF8

Assay Products for TNFRSF8:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for TNFRSF8 (CD30/TNFRSF8)
	GenScript Custom Assay Services for TNFRSF8
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TNFRSF8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNFRSF8 for domains About GeneDecksing

2 InterPro domains/families:

IPR001368 TNFR/NGFR_Cys_rich_reg

IPR020416 TNFR_8

Graphical View of Domain Structure for InterPro Entry P28908

ProtoNet protein and cluster: P28908

1 Blocks protein family: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908

Similarity: Contains 6 TNFR-Cys repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TNR8_HUMAN, P28908

Function: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of

activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B

Genatlas biochemistry entry for TNFRSF8:

tumor necrosis factor receptor superfamily,member 8,cell differentiation antigen CD30 (Ki-1),lymphoid

activating,identified by monoclonal antibodies HRS-1,Ki-1

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFRSF8
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFRSF8 (see all 12):
		hsa-miR-3679-3p hsa-miR-203 hsa-miR-623 hsa-miR-502-5p hsa-miR-211 hsa-miR-3922-3p hsa-miR-2355-5p hsa-miR-149

		SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFRSF8 (see all 7) OriGene shRNA RFP: TNFRSF8 OriGene siRNA: TNFRSF8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFRSF8

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TNFRSF8

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF8 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF8 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TNFRSF8 (NM_001243)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF8

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TNFRSF8
		Search LifeMap BioReagents cell lines for TNFRSF8

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF8

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane signaling receptor activity	TAS	1310894
GO:0005031	tumor necrosis factor-activated receptor activity	RCA	19641626

TNFRSF8 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for TNFRSF8:

Decreased Hepatitis C virus re

Increased HPV18 LCR reporter a

Animal Models:
Mouse knock-out Tnfrsf8^tm1Mak for TNFRSF8
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tnfrsf8):

cellular

hematopoietic system

immune system

TNFRSF8 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

0.46

Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway

0.46

PEDF Induced Signaling

STAT3 Pathway

0.47

Cytokine-cytokine receptor interaction

0.26

TRAF Pathway

TNF Superfamily Pathway

0.42

TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

0.08

TNF-alpha/NF-kB Signaling Pathway

TNF-alpha/NF-kB Signaling Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TNFRSF8

Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

1 R&D Systems Pathway for TNFRSF8

TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TNFRSF8 (see all 7)

	STAT3 Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	p38 Signaling
	Akt Signaling

1 GeneGo (Thomson Reuters) Pathway for TNFRSF8

Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

1 BioSystems Pathway for TNFRSF8

TNF-alpha/NF-kB Signaling Pathway

1 Kegg Pathway (Kegg details for TNFRSF8):

Cytokine-cytokine receptor interaction

TNFRSF8 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TNFRSF8

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/9 Interacting proteins for TNFRSF8 (P28908³ ENSP00000263932⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRAF5	O00463³, ENSP00000261464⁴	I2D: score=4 STRING: ENSP00000261464
TDP2	O95551³, ENSP00000367440⁴	I2D: score=3 STRING: ENSP00000367440
TNFSF8	P32971³, ENSP00000223795⁴	I2D: score=2 STRING: ENSP00000223795
ALK	Q9UM73³, ENSP00000373700⁴	I2D: score=1 STRING: ENSP00000373700
TRAF2	Q12933³, ENSP00000247668⁴	I2D: score=4 STRING: ENSP00000247668

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	10192335
GO:0008285	negative regulation of cell proliferation	TAS	10192335
GO:0033209	tumor necrosis factor-mediated signaling pathway	RCA	19641626
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	IDA	16108830
GO:0043065	positive regulation of apoptotic process	IDA	16108830

TNFRSF8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TNFRSF8 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNFRSF8
14 Novoseek chemical compound relationships for TNFRSF8 gene (see top 10) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
[alcl]	88.6	33	17965727 (5), 16140928 (3), 12754742 (2), 8055109 (1) (see all 15)
saporin	55	2	7517259 (1), 8903477 (1)
paraffin	49.7	7	7745117 (2), 8912826 (1), 11866962 (1), 12475440 (1) (see all 6)
ricin a	35.2	1	2152774 (1)
ricin	16.1	1	7591211 (1)
calcium	1.64	5	7866279 (1), 7527901 (1), 7869589 (1)
lipid	1.03	5	15034047 (3)
thymidine	0	1	8535215 (1)
tuberculin	0	1	8568238 (1)
threonine	0	1	16879614 (1)
zinc	0	5	7591296 (2)
tyrosine	0	2	8183550 (1), 10641597 (1)
serine	0	1	16879614 (1)
cyclosporin a	0	1	14551032 (1)

1 PharmGKB related drug/compound annotation for TNFRSF8 gene

Drug/compound	PharmGKB Annotation
brentuximab vedotin	DL

About this table

Search CenterWatch for drugs/clinical trials and news about TNFRSF8 / TNR8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNFRSF8 gene (2 alternative transcripts):

NM_001243.3 NM_152942.2

Unigene Cluster for TNFRSF8:

Tumor necrosis factor receptor superfamily, member 8

Hs.1314 [show with all ESTs]

Unigene Representative Sequence: NM_001243

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000263932(uc001atq.3 uc010obc.2) ENST00000514649 ENST00000413146(uc001atr.3 uc001ats.3)

ENST00000479933 ENST00000417814

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNFRSF8
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate TNFRSF8 (see all 12):
		hsa-miR-3679-3p hsa-miR-203 hsa-miR-623 hsa-miR-502-5p hsa-miR-211 hsa-miR-3922-3p hsa-miR-2355-5p hsa-miR-149

		SwitchGear 3'UTR luciferase reporter plasmid: TNFRSF8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFRSF8 (see all 7) OriGene shRNA RFP: TNFRSF8 OriGene siRNA: TNFRSF8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFRSF8

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF8 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF8 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TNFRSF8 (NM_001243)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF8

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFRSF8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TNFRSF8
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF8

Additional cDNA sequence:

BC063482.1 BC073839.1 BC136400.1 BC141804.1 BC171762.1 D86042.1 M83554.1 S75768.1

3 DOTS entries:

DT.310731 DT.91720897 DT.95153621

22 AceView cDNA sequences:

NM_152942 NM_001243 BC073839 BX110183 BC063482 BF591056 AA047161 BE877671

AA310772 BV199006 M83554 D86042 BU927609 BI909097 AA147594 AI203419

BI908989 AI699969 BP430908 AA928635 BG495230 AA047162

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNFRSF8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCAACAAA

About this image

TNFRSF8 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TNFRSF8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNFRSF8

SOURCE GeneReport for Unigene cluster: Hs.1314

SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF8 (see all 8):

Cell Surface Markers in human mouse rat

Th1/Th2 Response in human mouse rat

TNF Ligands & Receptors in human mouse rat

Apoptosis 384HT in human mouse rat

T-Cell Anergy & Immune Tolerance in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFRSF8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TNFRSF8
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF8

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF8 gene from 2/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tnfrsf8^{1 , 5}	tumor necrosis factor receptor superfamily, member more^{1, 5}	63.8(n)¹ 52.76(a)¹		4 (78.17 cM)⁵ 21941¹ NM_009401.2¹ NP_033427.1¹ 145267137⁵
chicken (Gallus gallus)	Aves	TNFRSF8¹	tumor necrosis factor receptor superfamily, member more	49.38(n) 38.11(a)		395090 NM_204444.1 NP_989775.1

ENSEMBL Gene Tree for TNFRSF8 (if available)
TreeFam Gene Tree for TNFRSF8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76011809^1,2		--	12121459(+)	`GCCATA/GTCACC`	1	--	us2k¹		0	--	--	--	--
rs116783306^1,2	F,	--	12121525(+)	`TCTTGC/TGTTCC`	1	--	us2k¹		1		WA	118
rs142383347^1,2		--	12121682(+)	`AAGGGA/GCATGA`	1	--	us2k¹		0	--	--	--	--
rs77732487^1,2	F,	--	12121802(+)	`CCCTAT/GAGGGC`	1	--	us2k¹		1		WA	118
rs77054165^1,2	C,F,	--	12122144(+)	`GGCTTG/AAATCA`	1	--	us2k¹		1		EA	120
rs117552217^1,2	F,	--	12122175(+)	`CAGCCG/ACCTCC`	1	--	us2k¹		1		EA	120
rs147799282^1,2		--	12122270(+)	`TCCATC/TTACCA`	1	--	us2k¹		0	--	--	--	--
rs113662668^1,2	C,	--	12122309(+)	`CTGCTCATC/- CATCC`	1	--	us2k¹		1		CSA	2
rs9702005^1,2	A	--	12122332(+)	`atccaC/Tctatg`	1	--	us2k¹		0	--	--	--	--
rs61777860^1,2	C,	--	12122373(+)	`TCCATC/TCACCC`	1	--	us2k¹		1		WA	2

HapMap Linkage Disequilibrium report for TNFRSF8 (12123434 - 12204264 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TNFRSF8
1 CNV: 0676
1 Indel: 58329

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFRSF8

DNA2.0 Custom Variant and Variant Library Synthesis for TNFRSF8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TNFRSF8 for disorders           About GeneDecksing

OMIM gene information: 153243    OMIM disorders: --

20/106 diseases for TNFRSF8 (see all 106):    About MalaCards

lymphomatoid papulosis interdigitating dendritic cell sarcoma lymphoepithelioma-like carcinoma b-cell non-hodgkin lymphoma

malignant fibrous histiocytoma fibrous histiocytoma anaplastic large cell lymphoma diffuse large b-cell lymphoma

non-hodgkin lymphoma human immunodeficiency virus infectious disease severe combined immunodeficiency infectious mononucleosis

mycosis fungoides graft versus host disease splenic abscess b-cell lymphomas

plasmodium falciparum malaria common variable immunodeficiency mast-cell leukemia testicular germ cell tumor

3 diseases from the University of Copenhagen DISEASES database for TNFRSF8:

Reticulosarcoma Malignant histiocytosis Lymphoma

10/75 Novoseek disease relationships for TNFRSF8 gene (see all 75) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
anaplastic large cell lymphoma	95.2	70	8183550 (4), 8960041 (2), 12754742 (2), 17965727 (2) (see all 55)
hodgkin disease	87.9	79	11004694 (2), 12754742 (2), 12875982 (2), 9209650 (2) (see all 67)
lymphomatoid papulosis	87.3	14	11121138 (2), 15894695 (2), 1344811 (1), 10556192 (1) (see all 7)
lymphoma large cell	84.2	20	11729213 (2), 1335094 (1), 11891807 (1), 8390600 (1) (see all 15)
lymphoma	79.9	72	11594583 (3), 1330287 (3), 19131793 (2), 10628334 (2) (see all 52)
lymphoma pleomorphic	79.2	1	10672058 (1)
lymphoma t-cell peripheral	74	4	7982672 (1), 1652981 (1), 8513200 (1), 12645345 (1)
lymphoma non-hodgkins	71.9	23	8055109 (2), 7982672 (1), 7564510 (1), 10793083 (1) (see all 22)
lymphoma t-cell	71.5	14	1659246 (1), 12692428 (1), 1509528 (1), 15328201 (1) (see all 13)
lymphoproliferative disorders	69.9	7	15894695 (3), 10793083 (1), 17320171 (1), 16882190 (1) (see all 5)

Genetic Association Database (GAD): TNFRSF8
Human Genome Epidemiology (HuGE) Navigator: TNFRSF8 (10 documents)

Export disorders for TNFRSF8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TNFRSF8 gene, integrated from 9 sources (see all 450):
(articles sorted by number of sources associating them with TNFRSF8)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease. (PubMed id 1310894)^{1, 2, 3} Duerkop H.... Stein H. (1992)
Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the CD30 antigen from different sources. (PubMed id 7527901)^{1, 2, 9} Jung W....Pfreundschuh M. (1994)
Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population. (PubMed id 11960307)^{1, 4, 9} Ahmed S....Hara T. (2002)
Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). (PubMed id 9511754)^{1, 2, 9} Mizushima S.... Inoue J. (1998)
Distribution of human CD30 gene promoter microsatellite alleles in healthy and human immunodeficiency virus-1 infected populations. (PubMed id 12648280)^{1, 4} McIntyre M.Q....Abraham L.J. (2003)
Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily. (PubMed id 9168896)^{1, 2} Boucher L.-M.... Mak T.W. (1997)
Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. (PubMed id 8999898)^{1, 2} Aizawa S.... Watanabe T. (1997)
T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors. (PubMed id 8627180)^{1, 2} Lee S.Y.... Choi Y. (1996)
A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophages. (PubMed id 8839832)^{1, 2} Horie R.... Watanabe T. (1996)
Assignment of the human CD30 (Ki-1) gene to 1p36. (PubMed id 1330892)^{1, 3} Fonatsch C....Stein H. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 943	HGNC: 11923	AceView: TNFRSF8	Ensembl:ENSG00000120949	euGenes: HUgn943
ECgene: TNFRSF8	Kegg: 943	H-InvDB: TNFRSF8

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TNFRSF8	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNFRSF8	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/tnfrsf8/

Intellectual Property for TNFRSF8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TNFRSF8 gene:
Search GeneIP for patents involving TNFRSF8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of TNFRSF8
	Browse Purified and Recombinant Proteins at EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for TNFRSF8 (CD30/TNFRSF8)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for TNFRSF8 (CD30/TNFRSF8)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for TNFRSF8 (CD30/TNFRSF8)

	OriGene Antibodies for TNFRSF8		OriGene shRNA RFP for TNFRSF8
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNFRSF8		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNFRSF8
	OriGene Protein Over-expression Lysate for TNFRSF8		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TNFRSF8		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF8		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNFRSF8
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TNFRSF8		OriGene Custom Protein Services for TNFRSF8
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TNFRSF8
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNFRSF8
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNFRSF8
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNFRSF8
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNFRSF8
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF8

	GenScript Custom Purified and Recombinant Proteins Services for TNFRSF8		GenScript cDNA clones with any tag delivered in your preferred vector for TNFRSF8
	GenScript Custom Assay Services for TNFRSF8		GenScript Custom Superior Antibodies Services for TNFRSF8
	GenScript Custom overexpressing Cell Line Services for TNFRSF8		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TNFRSF8 promoter
	Search Chromatin IP Primers for TNFRSF8
	RT² qPCR Primer Assay in human, mouse, rat TNFRSF8
	GNC Network for TNFRSF8
	SABiosciences PCR Arrays including human, mouse, rat TNFRSF8

Search Tocris compounds for TNFRSF8

	Proteins and Antibodies for TNFRSF8
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Proteins for TNFRSF8
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TNFRSF8 antibodies
	TNFRSF8 proteins
	TNFRSF8 lysates

	Antibodies for TNFRSF8
	See all of Abcam's Antibodies, Kits and Proteins for TNFRSF8
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TNFRSF8 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TNFRSF8

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF8

	SwitchGear 3'UTR luciferase reporter plasmids for TNFRSF8
	SwitchGear Promoter luciferase reporter plasmids for TNFRSF8

ThermoFisher Antibody for TNFRSF8

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF8

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TNFRSF8 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TNFRSF8 Gene

tumor necrosis factor receptor superfamily, member 8

Aliases
for TNFRSF8 gene

Summaries
for TNFRSF8 gene

Genomic Views
for TNFRSF8 gene

Proteins
for TNFRSF8 gene

Protein Domains /
Families
for TNFRSF8 gene

Function
for TNFRSF8 gene

Pathways & Interactions
for TNFRSF8 gene

Drugs & Compounds
for TNFRSF8 gene

Transcripts
for TNFRSF8 gene

Expression
for TNFRSF8 gene

Orthologs
for TNFRSF8 gene

Paralogs
for TNFRSF8 gene

Genomic Variants
for TNFRSF8 gene

Disorders / Diseases
for TNFRSF8 gene

Publications
for TNFRSF8 gene

External Searches for TNFRSF8 gene

Genome Databases showing TNFRSF8 gene

Other Databases showing TNFRSF8 gene

Specialized Databases showing TNFRSF8 gene

Intellectual Property
for TNFRSF8 gene

Products
for TNFRSF8 gene

View Random Gene

Lymphoma Large Cell
Kaposi Sarcoma
Leukemia T-Cell
Dermatitis Atopic
Sclerosis
Lymphoma T-Cell
Thyroid Nodule
Anaplasia
allergy
malignant fibrous histiocytoma
Skin Diseases
Breast Cancer
anaplastic large cell lymphoma
primary tumor
AIDS
Asthma
Mycosis Fungoides
Seminoma
Allergic rhinitis
Cancer
Lymphoma
Miscarriage
Lymphoma Pleomorphic
effusion
Inflammation
Burkitt Lymphoma
Tuberculosis
SKIN NODULE
Lymphosarcoma
immunodeficiency
Hepatitis B
MYELOMA
Therapeutic abortion
Rheumatoid Arthritis
Tumors
Malignant histiocytosis
Lymphomatoid Papulosis
Necrosis
Autoimmunity
Pseudolymphoma
Asthma allergic
Lymphoma T-Cell Cutaneous
virus infection
progressive disease
neoplastic transformation
HD adult
lymphoid neoplasm
Pemphigoid Bullous
SUBCUTANEOUS NODULE
Carcinoma
Hodgkin Disease
Infectious disease
epithelial tumor
Osteosarcoma
Severe Combined Immunodeficiency
Hematologic Malignancies
Sarcoma Synovial
Lymphoma B-Cell
NASOPHARYNGEAL CARCINOMA
Adenoma
Lymphoproliferative Disorders
mesothelioma
Giant Cell Tumors
Lymphocytic Leukemia Chronic B-Cell
Ewings sarcoma
Histopathology
SKIN LESION
Lymphoma Large Cell Diffuse
Infectious Mononucleosis
Granuloma
Carcinoma Embryonal
Plasmacytoma
Lymphoma Non-Hodgkins
Yolk Sac Tumor
Lymphoma T-Cell Peripheral

Advanced Search

Export list of displayed genes

TNFRSF8 Gene

tumor necrosis factor receptor superfamily, member 8

Aliasesfor TNFRSF8 gene

Summariesfor TNFRSF8 gene

Genomic Viewsfor TNFRSF8 gene

Proteinsfor TNFRSF8 gene

Protein Domains /Familiesfor TNFRSF8 gene

Functionfor TNFRSF8 gene

Pathways & Interactionsfor TNFRSF8 gene

Drugs & Compoundsfor TNFRSF8 gene

Transcriptsfor TNFRSF8 gene

Expression for TNFRSF8 gene

Orthologsfor TNFRSF8 gene

Paralogsfor TNFRSF8 gene

Genomic Variantsfor TNFRSF8 gene

Disorders / Diseasesfor TNFRSF8 gene

Publicationsfor TNFRSF8 gene

External Searches for TNFRSF8 gene

Genome Databases showing TNFRSF8 gene

Other Databases showing TNFRSF8 gene

Specialized Databases showing TNFRSF8 gene

Intellectual Propertyfor TNFRSF8 gene

Productsfor TNFRSF8 gene

View Random Gene

Aliases
for TNFRSF8 gene

Summaries
for TNFRSF8 gene

Genomic Views
for TNFRSF8 gene

Proteins
for TNFRSF8 gene

Protein Domains /
Families
for TNFRSF8 gene

Function
for TNFRSF8 gene

Pathways & Interactions
for TNFRSF8 gene

Drugs & Compounds
for TNFRSF8 gene

Transcripts
for TNFRSF8 gene

Expression
for TNFRSF8 gene

Orthologs
for TNFRSF8 gene

Paralogs
for TNFRSF8 gene

Genomic Variants
for TNFRSF8 gene

Disorders / Diseases
for TNFRSF8 gene

Publications
for TNFRSF8 gene

Intellectual Property
for TNFRSF8 gene

Products
for TNFRSF8 gene