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Aliases for TNFRSF6B Gene

Aliases for TNFRSF6B Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy 2 3
  • DCR3 3 4 6
  • Decoy Receptor For Fas Ligand 3 4
  • Decoy Receptor 3 3 4
  • M68 3 4
  • TR6 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 6B 3
  • DJ583P15.1.1 3
  • M68E 3

External Ids for TNFRSF6B Gene

Summaries for TNFRSF6B Gene

Entrez Gene Summary for TNFRSF6B Gene

  • This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]

GeneCards Summary for TNFRSF6B Gene

TNFRSF6B (Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy) is a Protein Coding gene. Diseases associated with TNFRSF6B include crescentic glomerulonephritis and colon adenocarcinoma. Among its related pathways are ERK Signaling and Metabolism. GO annotations related to this gene include receptor activity. An important paralog of this gene is TNFRSF14.

UniProtKB/Swiss-Prot for TNFRSF6B Gene

  • Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.

Gene Wiki entry for TNFRSF6B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF6B Gene

Genomics for TNFRSF6B Gene

Genomic Location for TNFRSF6B Gene

63,696,651 bp from pter
63,698,698 bp from pter
2,048 bases
Plus strand

Genomic View for TNFRSF6B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF6B Gene

Regulatory Elements for TNFRSF6B Gene

Transcription factor binding sites by QIAGEN in the TNFRSF6B gene promoter:

Proteins for TNFRSF6B Gene

  • Protein details for TNFRSF6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 6B
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TNFRSF6B Gene

    300 amino acids
    Molecular mass:
    32680 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TNFRSF6B Gene

neXtProt entry for TNFRSF6B Gene

Proteomics data for TNFRSF6B Gene at MOPED

Post-translational modifications for TNFRSF6B Gene

Other Protein References for TNFRSF6B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFRSF6B Gene

Domains for TNFRSF6B Gene

Gene Families for TNFRSF6B Gene

  • TNFRSF :Tumor necrosis factor receptor superfamily

Protein Domains for TNFRSF6B Gene

Suggested Antigen Peptide Sequences for TNFRSF6B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 TNFR-Cys repeats.:
    • O95407
genes like me logo Genes that share domains with TNFRSF6B: view

Function for TNFRSF6B Gene

Molecular function for TNFRSF6B Gene

GENATLAS Biochemistry: tumor necrosis factor receptor superfamily,member 6B,binding Fas ligand (TNFRSF6) and inhibiting FasL induced apoptosis,amplified in primary lung and colon tumors
UniProtKB/Swiss-Prot Function: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.

Gene Ontology (GO) - Molecular Function for TNFRSF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9872321
GO:0005515 protein binding IPI 10318773
genes like me logo Genes that share ontologies with TNFRSF6B: view

miRNA for TNFRSF6B Gene

miRTarBase miRNAs that target TNFRSF6B

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TNFRSF6B Gene

Localization for TNFRSF6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF6B Gene


Subcellular locations from

Jensen Localization Image for TNFRSF6B Gene COMPARTMENTS Subcellular localization image for TNFRSF6B gene
Compartment Confidence
extracellular 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TNFRSF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space NAS 10318773
genes like me logo Genes that share ontologies with TNFRSF6B: view

Pathways for TNFRSF6B Gene

genes like me logo Genes that share pathways with TNFRSF6B: view

Pathways by source for TNFRSF6B Gene

3 Sino Biological pathways for TNFRSF6B Gene
1 GeneGo (Thomson Reuters) pathway for TNFRSF6B Gene
1 Cell Signaling Technology pathway for TNFRSF6B Gene
1 BioSystems pathway for TNFRSF6B Gene
2 Reactome pathways for TNFRSF6B Gene
1 KEGG pathway for TNFRSF6B Gene

Gene Ontology (GO) - Biological Process for TNFRSF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0043066 negative regulation of apoptotic process TAS 9872321
genes like me logo Genes that share ontologies with TNFRSF6B: view

Compounds for TNFRSF6B Gene

(1) Novoseek inferred chemical compound relationships for TNFRSF6B Gene

Compound -log(P) Hits PubMed IDs
phosphatidylinositol 11.3 3
genes like me logo Genes that share compounds with TNFRSF6B: view

Transcripts for TNFRSF6B Gene


(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(190) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFRSF6B Gene

Tumor necrosis factor receptor superfamily, member 6b, decoy:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF6B Gene

No ASD Table

Relevant External Links for TNFRSF6B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF6B Gene

mRNA expression in normal human tissues for TNFRSF6B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNFRSF6B Gene

SOURCE GeneReport for Unigene cluster for TNFRSF6B Gene Hs.434878

mRNA Expression by UniProt/SwissProt for TNFRSF6B Gene

Tissue specificity: Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells
genes like me logo Genes that share expressions with TNFRSF6B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TNFRSF6B Gene

Orthologs for TNFRSF6B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF6B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNFRSF6B 35
  • 81.65 (n)
  • 79.14 (a)
  • 74 (a)
(Canis familiaris)
Mammalia TNFRSF6B 35
  • 82.57 (n)
  • 79.39 (a)
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia TNFRSF6B 36
  • 46 (a)
(Gallus gallus)
Aves TNFRSF6B 35
  • 63.52 (n)
  • 54.34 (a)
  • 48 (a)
(Anolis carolinensis)
Reptilia TNFRSF6B 36
  • 54 (a)
(Danio rerio)
Actinopterygii tnfrsf11b 36
  • 25 (a)
Species with no ortholog for TNFRSF6B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF6B Gene

Gene Tree for TNFRSF6B (if available)
Gene Tree for TNFRSF6B (if available)

Paralogs for TNFRSF6B Gene

Paralogs for TNFRSF6B Gene

Selected SIMAP similar genes for TNFRSF6B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TNFRSF6B: view

Variants for TNFRSF6B Gene

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF6B Gene

Variant ID Type Subtype PubMed ID
dgv4618n71 CNV Loss 21882294
nsv913190 CNV Loss 21882294
dgv1344e1 CNV Complex 17122850
nsv913213 CNV Loss 21882294
nsv470563 CNV Loss 18288195
dgv4644n71 CNV Loss 21882294
dgv1345e1 CNV Complex 17122850
nsv428381 CNV Gain+Loss 18775914
nsv913241 CNV Loss 21882294
dgv4645n71 CNV Loss 21882294
dgv4646n71 CNV Loss 21882294
dgv4647n71 CNV Loss 21882294
nsv913249 CNV Loss 21882294
nsv913250 CNV Loss 21882294
nsv913253 CNV Loss 21882294

Relevant External Links for TNFRSF6B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TNFRSF6B Gene

Disorders for TNFRSF6B Gene

(23) Novoseek inferred disease relationships for TNFRSF6B Gene

Disease -log(P) Hits PubMed IDs
necrosis 56.7 33
tumors 49.8 79
herpes 44.6 4
pancreatic carcinoma 41.2 1
colon adenocarcinoma 40.8 3

Relevant External Links for TNFRSF6B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TNFRSF6B: view

No data available for UniProtKB/Swiss-Prot for TNFRSF6B Gene

Publications for TNFRSF6B Gene

  1. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. (PMID: 9872321) Pitti R.M. … Ashkenazi A. (Nature 1998) 2 3 4 23
  2. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. (PMID: 10318773) Yu K.-Y. … Kwon B.S. (J. Biol. Chem. 1999) 2 3 4 23
  3. Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. (PMID: 10655513) Bai C. … Caskey C.T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23
  4. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. (PMID: 18758464) Kugathasan S. … Hakonarson H. (Nat. Genet. 2008) 3 23 48
  5. Decoy receptor 3 is a prognostic factor in renal cell cancer. (PMID: 18813347) Macher-Goeppinger S. … Roth W. (Neoplasia 2008) 3 23

Products for TNFRSF6B Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Copy Number PCR Panels: for TNFRSF6B
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis 384HT in human,mouse,rat
    • TNF Ligands & Receptors in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TNFRSF6B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF6B
    • Block miRNA regulation of TNFRSF6B using miScript Target Protectors

    Sources for TNFRSF6B Gene

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