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Aliases for TNFRSF6B Gene

Aliases for TNFRSF6B Gene

  • TNF Receptor Superfamily Member 6b 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy 2 3
  • Decoy Receptor For Fas Ligand 3 4
  • DCR3 3 4
  • M68 3 4
  • TR6 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 6B 3
  • Decoy Receptor 3 Variant 1 3
  • Decoy Receptor 3 Variant 2 3
  • Decoy Receptor 3 4
  • DJ583P15.1.1 3
  • M68E 3

External Ids for TNFRSF6B Gene

Previous GeneCards Identifiers for TNFRSF6B Gene

  • GC20P062166
  • GC20U900077
  • GC20P063052
  • GC20P063016
  • GC20P061761
  • GC20P062326
  • GC20P059059

Summaries for TNFRSF6B Gene

Entrez Gene Summary for TNFRSF6B Gene

  • This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]

GeneCards Summary for TNFRSF6B Gene

TNFRSF6B (TNF Receptor Superfamily Member 6b) is a Protein Coding gene. Diseases associated with TNFRSF6B include Bladder Urothelial Carcinoma and Oral Cavity Cancer. Among its related pathways are Apoptosis and Autophagy and Innate Immune System. GO annotations related to this gene include receptor activity. An important paralog of this gene is TNFRSF11B.

UniProtKB/Swiss-Prot for TNFRSF6B Gene

  • Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.

Gene Wiki entry for TNFRSF6B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF6B Gene

Genomics for TNFRSF6B Gene

Regulatory Elements for TNFRSF6B Gene

Enhancers for TNFRSF6B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G063845 1.6 Ensembl ENCODE dbSUPER 39.2 +150.7 150676 3.3 HDGF FOXA2 PKNOX1 ARNT AGO1 ARID4B SIN3A YBX1 FEZF1 DMAP1 TNFRSF6B PCMTD2 MIR647 RTEL1 ZNF512B UCKL1 ZBTB46-AS1 DNAJC5 PRPF6 C20orf204
GH20G064062 1.7 Ensembl ENCODE dbSUPER 22.7 +368.2 368196 5.3 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC RGS19 RTEL1 TNFRSF6B ARFGAP1 MIR647 ZNF512B PRPF6 UCKL1 TCEA2 C20orf204
GH20G063953 1.4 ENCODE dbSUPER 20.2 +259.9 259857 5.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 RTEL1 UCKL1 TNFRSF6B PRPF6 MIR647 STMN3 HAR1A ZBTB46 ZNF512B PIR62018
GH20G063455 1.1 dbSUPER 22.8 -239.5 -239547 2.2 HDGF PKNOX1 FOXA2 CREB3L1 ZBTB7B ZNF207 FOS SP3 JUNB ZHX2 RTEL1 TNFRSF6B MIR647 EEF1A2 PCMTD2 ZNF512B ARFGAP1 LOC105372725 PRPF6 ZBTB46
GH20G062860 1.1 ENCODE 20.3 -835.0 -834975 2.9 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 TNFRSF6B TCFL5 RTEL1 ZBTB46 LOC105372717
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFRSF6B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TNFRSF6B gene promoter:

Genomic Location for TNFRSF6B Gene

Chromosome:
20
Start:
63,696,651 bp from pter
End:
63,698,698 bp from pter
Size:
2,048 bases
Orientation:
Plus strand

Genomic View for TNFRSF6B Gene

Genes around TNFRSF6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF6B Gene

Proteins for TNFRSF6B Gene

  • Protein details for TNFRSF6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95407-TNF6B_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 6B
    Protein Accession:
    O95407

    Protein attributes for TNFRSF6B Gene

    Size:
    300 amino acids
    Molecular mass:
    32680 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TNFRSF6B Gene

neXtProt entry for TNFRSF6B Gene

Post-translational modifications for TNFRSF6B Gene

  • Glycosylation at posLast=173173
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF6B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFRSF6B (DcR3/TNFRSF6B)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF6B (TNFRSF6B)
  • Abcam antibodies for TNFRSF6B

No data available for DME Specific Peptides for TNFRSF6B Gene

Domains & Families for TNFRSF6B Gene

Gene Families for TNFRSF6B Gene

Protein Domains for TNFRSF6B Gene

Suggested Antigen Peptide Sequences for TNFRSF6B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFRSF6B: view

No data available for UniProtKB/Swiss-Prot for TNFRSF6B Gene

Function for TNFRSF6B Gene

Molecular function for TNFRSF6B Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 6B,binding Fas ligand (TNFRSF6) and inhibiting FasL induced apoptosis,amplified in primary lung and colon tumors
UniProtKB/Swiss-Prot Function:
Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.

Gene Ontology (GO) - Molecular Function for TNFRSF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9872321
GO:0005031 tumor necrosis factor-activated receptor activity IBA --
GO:0005515 protein binding IPI 10318773
genes like me logo Genes that share ontologies with TNFRSF6B: view
genes like me logo Genes that share phenotypes with TNFRSF6B: view

Animal Model Products

CRISPR Products

miRNA for TNFRSF6B Gene

miRTarBase miRNAs that target TNFRSF6B

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFRSF6B Gene

Localization for TNFRSF6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF6B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF6B gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TNFRSF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space NAS 10318773
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with TNFRSF6B: view

Pathways & Interactions for TNFRSF6B Gene

genes like me logo Genes that share pathways with TNFRSF6B: view

Pathways by source for TNFRSF6B Gene

1 Sino Biological pathway for TNFRSF6B Gene
1 Cell Signaling Technology pathway for TNFRSF6B Gene
1 BioSystems pathway for TNFRSF6B Gene
1 KEGG pathway for TNFRSF6B Gene
1 GeneGo (Thomson Reuters) pathway for TNFRSF6B Gene

SIGNOR curated interactions for TNFRSF6B Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TNFRSF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007275 multicellular organism development IBA --
GO:0032496 response to lipopolysaccharide IBA --
genes like me logo Genes that share ontologies with TNFRSF6B: view

Drugs & Compounds for TNFRSF6B Gene

(1) Additional Compounds for TNFRSF6B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF6B: view

Transcripts for TNFRSF6B Gene

mRNA/cDNA for TNFRSF6B Gene

Unigene Clusters for TNFRSF6B Gene

Tumor necrosis factor receptor superfamily, member 6b, decoy:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF6B Gene

No ASD Table

Relevant External Links for TNFRSF6B Gene

GeneLoc Exon Structure for
TNFRSF6B
ECgene alternative splicing isoforms for
TNFRSF6B

Expression for TNFRSF6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF6B Gene

Protein differential expression in normal tissues from HIPED for TNFRSF6B Gene

This gene is overexpressed in Breast (41.3) and Cervix (27.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF6B Gene



Protein tissue co-expression partners for TNFRSF6B Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF6B Gene:

TNFRSF6B

SOURCE GeneReport for Unigene cluster for TNFRSF6B Gene:

Hs.434878

mRNA Expression by UniProt/SwissProt for TNFRSF6B Gene:

O95407-TNF6B_HUMAN
Tissue specificity: Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Evidence on tissue expression from TISSUES for TNFRSF6B Gene

  • Lung(4.3)
  • Skin(4)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with TNFRSF6B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF6B Gene

Orthologs for TNFRSF6B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF6B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TNFRSF6B 34 35
  • 82.57 (n)
cow
(Bos Taurus)
Mammalia TNFRSF6B 34 35
  • 81.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TNFRSF6B 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNFRSF6B 34 35
  • 63.52 (n)
lizard
(Anolis carolinensis)
Reptilia TNFRSF6B 35
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tnfrsf11b 35
  • 25 (a)
OneToMany
Species where no ortholog for TNFRSF6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF6B Gene

ENSEMBL:
Gene Tree for TNFRSF6B (if available)
TreeFam:
Gene Tree for TNFRSF6B (if available)

Paralogs for TNFRSF6B Gene

Paralogs for TNFRSF6B Gene

(2) SIMAP similar genes for TNFRSF6B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TNFRSF6B: view

Variants for TNFRSF6B Gene

Sequence variations from dbSNP and Humsavar for TNFRSF6B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs201540674 Pathogenic 63,695,619(+) CCAGC(A/G)CTGCC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs587777037 Pathogenic 63,695,558(+) GTGTG(C/T)GCCAG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs786205702 Pathogenic 63,695,093(+) ACACC(A/C)CAAGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs754782569 Likely benign 63,698,309(+) TCATC(A/G)ACTTT nc-transcript-variant, downstream-variant-500B, reference, missense
rs797045923 Uncertain significance 63,695,443(+) CAGTC(C/T)TCAGG nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF6B Gene

Variant ID Type Subtype PubMed ID
dgv7676n54 CNV loss 21841781
esv2758806 CNV gain+loss 17122850
nsv1160690 CNV deletion 26073780
nsv428381 CNV gain+loss 18775914
nsv470563 CNV loss 18288195
nsv586611 CNV loss 21841781
nsv953308 CNV deletion 24416366

Variation tolerance for TNFRSF6B Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF6B Gene

Human Gene Mutation Database (HGMD)
TNFRSF6B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF6B Gene

Disorders for TNFRSF6B Gene

MalaCards: The human disease database

(3) MalaCards diseases for TNFRSF6B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bladder urothelial carcinoma
  • bladder transitional cell carcinoma
oral cavity cancer
  • malignant neoplasm of anterior portion of floor of mouth
pancreatic cancer
  • pancreatic carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFRSF6B

Genetic Association Database (GAD)
TNFRSF6B
Human Genome Epidemiology (HuGE) Navigator
TNFRSF6B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNFRSF6B
genes like me logo Genes that share disorders with TNFRSF6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF6B Gene

Publications for TNFRSF6B Gene

  1. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. (PMID: 10318773) Yu K.-Y. … Kwon B.S. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. (PMID: 9872321) Pitti R.M. … Ashkenazi A. (Nature 1998) 2 3 4 22 64
  3. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. (PMID: 18758464) Kugathasan S. … Hakonarson H. (Nat. Genet. 2008) 3 22 46 64
  4. Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. (PMID: 10655513) Bai C. … Caskey C.T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 22 64
  5. Decoy strategies: the structure of TL1A:DcR3 complex. (PMID: 21300286) Zhan C. … Almo S.C. (Structure 2011) 3 4 64

Products for TNFRSF6B Gene

Sources for TNFRSF6B Gene

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