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Aliases for TNFRSF6B Gene

Aliases for TNFRSF6B Gene

  • TNF Receptor Superfamily Member 6b 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy 2 3
  • Decoy Receptor For Fas Ligand 3 4
  • DCR3 3 4
  • M68 3 4
  • TR6 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 6B 3
  • Decoy Receptor 3 Variant 1 3
  • Decoy Receptor 3 Variant 2 3
  • Decoy Receptor 3 4
  • DJ583P15.1.1 3
  • M68E 3

External Ids for TNFRSF6B Gene

Previous GeneCards Identifiers for TNFRSF6B Gene

  • GC20P062166
  • GC20U900077
  • GC20P063052
  • GC20P063016
  • GC20P061761
  • GC20P062326
  • GC20P059059

Summaries for TNFRSF6B Gene

Entrez Gene Summary for TNFRSF6B Gene

  • This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]

GeneCards Summary for TNFRSF6B Gene

TNFRSF6B (TNF Receptor Superfamily Member 6b) is a Protein Coding gene. Diseases associated with TNFRSF6B include Bladder Urothelial Carcinoma and Pancreatic Cancer. Among its related pathways are TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions and Immune System. GO annotations related to this gene include receptor activity. An important paralog of this gene is TNFRSF11B.

UniProtKB/Swiss-Prot for TNFRSF6B Gene

  • Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.

Gene Wiki entry for TNFRSF6B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF6B Gene

Genomics for TNFRSF6B Gene

Regulatory Elements for TNFRSF6B Gene

Enhancers for TNFRSF6B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F063452 1.7 FANTOM5 Ensembl ENCODE 13.6 -241.8 -241819 5.5 HDGF PKNOX1 CREB3L1 ZNF207 FOS ZNF263 SP3 JUNB ZHX2 REST MIR647 RTEL1 ENSG00000226390 EEF1A2 ZNF512B KCNQ2 ARFGAP1 TNFRSF6B LOC105372725 MIR1914
GH20F063844 1.3 Ensembl ENCODE 11 +150.3 150250 4.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YBX1 FEZF1 DMAP1 YY1 SLC30A9 PRPF6 MIR647 MIR1914 ENSG00000237371 ZBTB46-AS1 CICP4 DNAJC5 TNFRSF6B UCKL1 LIME1
GH20F062913 1.3 Ensembl ENCODE 10.9 -781.6 -781556 4.0 ATF1 MLX ARID4B SIN3A DMAP1 YBX1 ZNF48 ZNF121 SLC30A9 FOS DIDO1 GID8 TCFL5 TNFRSF6B SLC17A9 ENSG00000273759 ARF4P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNFRSF6B on UCSC Golden Path with GeneCards custom track

Genomic Location for TNFRSF6B Gene

63,696,651 bp from pter
63,698,698 bp from pter
2,048 bases
Plus strand

Genomic View for TNFRSF6B Gene

Genes around TNFRSF6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF6B Gene

Proteins for TNFRSF6B Gene

  • Protein details for TNFRSF6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 6B
    Protein Accession:

    Protein attributes for TNFRSF6B Gene

    300 amino acids
    Molecular mass:
    32680 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TNFRSF6B Gene

neXtProt entry for TNFRSF6B Gene

Post-translational modifications for TNFRSF6B Gene

  • Glycosylation at Asn 173
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF6B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFRSF6B (DcR3/TNFRSF6B)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF6B (TNFRSF6B)
  • Abcam antibodies for TNFRSF6B

No data available for DME Specific Peptides for TNFRSF6B Gene

Domains & Families for TNFRSF6B Gene

Gene Families for TNFRSF6B Gene

Protein Domains for TNFRSF6B Gene

Suggested Antigen Peptide Sequences for TNFRSF6B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 TNFR-Cys repeats.
  • Contains 4 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF6B: view

Function for TNFRSF6B Gene

Molecular function for TNFRSF6B Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 6B,binding Fas ligand (TNFRSF6) and inhibiting FasL induced apoptosis,amplified in primary lung and colon tumors
UniProtKB/Swiss-Prot Function:
Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.

Gene Ontology (GO) - Molecular Function for TNFRSF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9872321
GO:0005031 tumor necrosis factor-activated receptor activity IBA --
GO:0005515 protein binding IPI 10318773
genes like me logo Genes that share ontologies with TNFRSF6B: view
genes like me logo Genes that share phenotypes with TNFRSF6B: view

Animal Model Products

miRNA for TNFRSF6B Gene

miRTarBase miRNAs that target TNFRSF6B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFRSF6B Gene

Localization for TNFRSF6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF6B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF6B gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TNFRSF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space NAS 10318773
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with TNFRSF6B: view

Pathways & Interactions for TNFRSF6B Gene

genes like me logo Genes that share pathways with TNFRSF6B: view

Pathways by source for TNFRSF6B Gene

1 Sino Biological pathway for TNFRSF6B Gene
1 Cell Signaling Technology pathway for TNFRSF6B Gene
1 BioSystems pathway for TNFRSF6B Gene
1 KEGG pathway for TNFRSF6B Gene
1 GeneGo (Thomson Reuters) pathway for TNFRSF6B Gene

SIGNOR curated interactions for TNFRSF6B Gene


Gene Ontology (GO) - Biological Process for TNFRSF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007275 multicellular organism development IBA --
GO:0032496 response to lipopolysaccharide IBA --
genes like me logo Genes that share ontologies with TNFRSF6B: view

Drugs & Compounds for TNFRSF6B Gene

(1) Additional Compounds for TNFRSF6B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF6B: view

Transcripts for TNFRSF6B Gene


Unigene Clusters for TNFRSF6B Gene

Tumor necrosis factor receptor superfamily, member 6b, decoy:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF6B Gene

No ASD Table

Relevant External Links for TNFRSF6B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFRSF6B Gene

Protein differential expression in normal tissues from HIPED for TNFRSF6B Gene

This gene is overexpressed in Breast (41.3) and Cervix (27.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF6B Gene

Protein tissue co-expression partners for TNFRSF6B Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF6B Gene:


SOURCE GeneReport for Unigene cluster for TNFRSF6B Gene:


mRNA Expression by UniProt/SwissProt for TNFRSF6B Gene:

Tissue specificity: Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.
genes like me logo Genes that share expression patterns with TNFRSF6B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TNFRSF6B Gene

Orthologs for TNFRSF6B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF6B Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TNFRSF6B 34 35
  • 82.57 (n)
(Bos Taurus)
Mammalia TNFRSF6B 34 35
  • 81.65 (n)
(Ornithorhynchus anatinus)
Mammalia TNFRSF6B 35
  • 46 (a)
(Gallus gallus)
Aves TNFRSF6B 34 35
  • 63.52 (n)
(Anolis carolinensis)
Reptilia TNFRSF6B 35
  • 54 (a)
(Danio rerio)
Actinopterygii tnfrsf11b 35
  • 25 (a)
Species where no ortholog for TNFRSF6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF6B Gene

Gene Tree for TNFRSF6B (if available)
Gene Tree for TNFRSF6B (if available)

Paralogs for TNFRSF6B Gene

Paralogs for TNFRSF6B Gene

(2) SIMAP similar genes for TNFRSF6B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TNFRSF6B: view

Variants for TNFRSF6B Gene

Sequence variations from dbSNP and Humsavar for TNFRSF6B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs201540674 Pathogenic 63,695,619(+) CCAGC(A/G)CTGCC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs587777037 Pathogenic 63,695,558(+) GTGTG(C/T)GCCAG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs786205702 Pathogenic 63,695,093(+) ACACC(A/C)CAAGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs754782569 Likely benign 63,698,309(+) TCATC(A/G)ACTTT nc-transcript-variant, downstream-variant-500B, reference, missense
rs797045923 Uncertain significance 63,695,443(+) CAGTC(C/T)TCAGG nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF6B Gene

Variant ID Type Subtype PubMed ID
nsv953308 CNV deletion 24416366
nsv586611 CNV loss 21841781
nsv470563 CNV loss 18288195
nsv428381 CNV gain+loss 18775914
nsv1160690 CNV deletion 26073780
esv2758806 CNV gain+loss 17122850
dgv7676n54 CNV loss 21841781

Variation tolerance for TNFRSF6B Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNFRSF6B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF6B Gene

Disorders for TNFRSF6B Gene

MalaCards: The human disease database

(3) MalaCards diseases for TNFRSF6B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bladder urothelial carcinoma
  • bladder transitional cell carcinoma
pancreatic cancer
  • pancreatic carcinoma, somatic
oral cavity cancer
  • malignant neoplasm of anterior portion of floor of mouth
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNFRSF6B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TNFRSF6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF6B Gene

Publications for TNFRSF6B Gene

  1. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. (PMID: 10318773) Yu K.-Y. … Kwon B.S. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. (PMID: 9872321) Pitti R.M. … Ashkenazi A. (Nature 1998) 2 3 4 22 64
  3. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. (PMID: 18758464) Kugathasan S. … Hakonarson H. (Nat. Genet. 2008) 3 22 46 64
  4. Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. (PMID: 10655513) Bai C. … Caskey C.T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 22 64
  5. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson C.A. … Rioux J.D. (Nat. Genet. 2011) 3 46 64

Products for TNFRSF6B Gene

Sources for TNFRSF6B Gene

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