Aliases for TNFRSF6B Gene
External Ids for TNFRSF6B Gene
Previous GeneCards Identifiers for TNFRSF6B Gene
This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
GeneCards Summary for TNFRSF6B Gene
TNFRSF6B (Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy) is a Protein Coding gene. Diseases associated with TNFRSF6B include silicosis and oral cavity cancer. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include receptor activity. An important paralog of this gene is TNFRSF14.
UniProtKB/Swiss-Prot for TNFRSF6B Gene
Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.