V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

TNFRSF6B Gene

protein-coding GIFtS: 60

GC20P061761

tumor necrosis factor receptor superfamily, member 6b, decoy
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DCR3 ^¹, ², ³, ⁵
DJ583P15.1.1 ^²
DcR3 ^¹, ³
M68 ^¹, ², ³
OTTHUMP00000031583 ^²
TR6 ^¹, ², ³

Descriptions
Decoy receptor 3 ^², ³
Decoy receptor for Fas ligand ^³
tumor necrosis factor receptor superfamily, member 6b ^²
tumor necrosis factor receptor superfamily, member 6b, decoy ^²

External Ids
HGNC: 11921¹
Entrez Gene: 8771²
UniProtKB: O95407³
Ensembl: ENSG00000026036⁷

Search outside databases for aliases for TNFRSF6B gene

Previous GC identifers: GC20P062166 GC20U900077 GC20P063052 GC20P063016

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TNFRSF6B:

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is

postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts

as a decoy receptor that competes with death receptors for ligand binding. Overexpression of this

gene has been noted in gastrointestinal tract tumors, and it is located in a gene-rich cluster on

chromosome 20, with other potentially tumor-related genes. Two transcript variants encoding the

same isoform, but differing in the 5' UTR, have been observed for this gene. [provided by

RefSeq]

UniProtKB/Swiss-Prot: TNF6B_HUMAN, O95407

Function: Decoy receptor for the cytotoxic ligands TNFS14/LIGHT and TNFSF6/FASL. Protects against

apoptosis

Gene Wiki entry for TNFRSF6B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TNFRSF6B gene

Entrez Gene cytogenetic band: 20q13.3 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.3

TNFRSF6B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P061761: (about GC identifiers)

Start:	61,759,607 bp from pter
End:	61,800,495 bp from pter
Size:	40,889 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_011333.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TNF6B_HUMAN, O95407 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 6B precursor

Size: 300 amino acids; 32680 Da

Subcellular location: Secreted

REFSEQ proteins (2 alternative transcripts):

NP_003814.1 NP_116563.1

ENSEMBL proteins:

ENSP00000359010 ENSP00000359013 ENSP00000359023 ENSP00000359020 ENSP00000359035 ENSP00000342328

ENSP00000349265 ENSP00000347362 ENSP00000322287 ENSP00000353332

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for TNFRSF6B
	R&D Systems Recombinant & Natural Proteins for TNFRSF6B (DcR3/TNFRSF6B)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (DcR3)
	Human Recombinant Proteins from Abnova (TNFRSF6B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005625	soluble fraction	TAS	9872321

About this table

Antibodies for TNFRSF6B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for TNFRSF6B
	R&D Systems Antibodies for TNFRSF6B (DcR3/TNFRSF6B)
	Cell Signaling Technology (CST) Antibodies for TNFRSF6B (dcr3)
	Antibodies from Abcam (DcR3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TNFRSF6B)
	Novus Biologicals Antibodies for TNFRSF6B

Assays for TNFRSF6B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for TNFRSF6B (DcR3/TNFRSF6B) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O95407

ProtoNet protein and cluster: O95407

1 Blocks protein family: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNF6B_HUMAN, O95407

Similarity: Contains 4 TNFR-Cys repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TNFRSF6B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003823

Applied Biosystems Silencer® siRNAs for TNFRSF6B

Sigma-Aldrich siRNA for TNFRSF6B

Sigma-Aldrich shRNA Panels and shRNA for TNFRSF6B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003823
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003823
untagged cDNA clones in CMV expression vector (see all 3): NM_003823

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003823

UniProtKB/Swiss-Prot: TNF6B_HUMAN, O95407

Function: Decoy receptor for the cytotoxic ligands TNFS14/LIGHT and TNFSF6/FASL. Protects against

apoptosis

Genatlas biochemistry entry for TNFRSF6B:

tumor necrosis factor receptor superfamily,member 6B,binding Fas ligand (TNFRSF6) and inhibiting

FasL induced apoptosis,amplified in primary lung and colon tumors

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	9872321
GO:0005515	protein binding	IPI	10318773

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for TNFRSF6B

5/11 Interacting proteins for TNFRSF6B (ENSP00000349265³ O95407¹) via UniProtKB, MINT, and/or STRING (see all 11 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TNFSF14	O43557¹	STRING (score=.989) EBI-524171, EBI-524131
FASLG	ENSP00000356694³	STRING (score=.999)
TNFSF15	ENSP00000363157³	STRING (score=.994)
TNFRSF1A	ENSP00000162749³	STRING (score=.886)
AKT1	ENSP00000270202³	STRING (score=.831)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptosis	IEA	--
GO:0006916	anti-apoptosis	TAS	9872321

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TNFRSF6B
1 Novoseek chemical compound relationship for TNFRSF6B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylinositol	15.38	3	14688085 (1), 19050262 (1), 14697332 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TNFRSF6B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003823

Sigma-Aldrich siRNA for TNFRSF6B

Sigma-Aldrich shRNA Panels and shRNA for TNFRSF6B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003823 NM_032945

REFSEQ mRNAs for TNFRSF6B gene (2 alternative transcripts):

NM_003823.2 NM_032945.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003823 NM_032945

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003823
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003823
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_003823

Additional cDNA sequence:

AF104419.1 AF134240.1 AF217793.1 AF217794.1 AF217795.1 AK000485.1 AK299332.1 AK302508.1

AK304798.1 AL080127.1 AY124378.1 AY124379.1 AY358279.1 BC017065.1 BC034349.1 BC131817.1

17 DOTS entries:

DT.101980777 DT.99984254 DT.100746777 DT.40230565 DT.100026806 DT.100746778 DT.97770485 DT.426887

DT.110158 DT.120825067 DT.102833296 DT.95349828 DT.91765245 DT.120824862 DT.75164637 DT.97792267

DT.100749378

24/190 AceView cDNA sequences (see all 190 ):

BM857412 AI857725 BM784181 AY124378 BE467871 BF001490 AI380034 AI446656

BM756086 BM742134 BU623385 NM_032957 BF987793 NM_003823 AF217795 AW135723

AA326540 AW955349 BM784338 BQ019285 AY358279 AI304479 AF104419 BE877829

highest scoring ESTs for TNFRSF6B:

AA025673 AA158406 AA514270 AA577603 AA603704 AA613366 AF104419 AF217794 AI185297 AI282851

Unigene Cluster for TNFRSF6B:

Tumor necrosis factor receptor superfamily, member 6b, decoy

Hs.434878 [show with all ESTs]

Unigene Representative Sequence: AF217795

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF6B (see all 12 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^
SP1:									-						-						-
SP2:
SP3:									-
SP4:							-		-		-		-		-						-
SP5:							-		-						-						-

ExUns:	19a	·	19b	^	20	^	21	^	22	^	23a	·	23b	^	24	^	25	^	26	^	27a	·	27b	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35	^	36a	·	36b	·	36c	^	37a	·	37b	^	38a	·
SP1:	-												-								-																								-
SP2:
SP3:
SP4:
SP5:

ExUns:	38b	·	38c	^	39a	·	39b	^	40
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for TNFRSF6B

10 Ensembl transcripts including schematic representations:

ENST00000369993 ENST00000369996 ENST00000370006 ENST00000370003 ENST00000370018 ENST00000342852

ENST00000356810 ENST00000355223 ENST00000318100 ENST00000360203

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TNFRSF6B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TNFRSF6B

¹ / ² / ³

2 probe-sets matching TNFRSF6B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
206467_x_at²^{, 3}	U133-A	4	1.00	0.47	--	--	NM_003823	0.60	0.83	0.73	1
206467_x_at²	U133Plus2	4	1.00	0.47	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.434878
Expression variation in blood from EXPOLDB for TNFRSF6B
UniProtKB/Swiss-Prot: TNF6B_HUMAN, O95407
Tissue specificity: Detected in fetal lung, brain and liver. Detected in adult stomach, spinal
cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from
colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TNFRSF6B gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	TNFRSF6B¹	--	tumor necrosis factor receptor superfamily, member more	81.77(n) 79.14(a)	789154 XM_001255991.1 XP_001255992.1
chicken (Gallus gallus)	TNFRSF6B¹	--	tumor necrosis factor receptor superfamily, member more	64.23(n) 54.38(a)	395096 XM_417434.2 XP_417434.2
zebrafish (Danio rerio)	LOC407674¹	--	hypothetical protein LOC407674	53.11(n) 37.85(a)	407674 XM_001334174.2 XP_001334210.1

About this table Species with no ortholog for TNFRSF6B

ENSEMBL Gene Tree for TNFRSF6B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TNFRSF6B gene

DDX12² DDX11² BRIP1² ERCC2² ENSG00000111788²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/14 NCBI SNPs in TNFRSF6B are shown (see all 14 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 49)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2257440^1,2	A,C,F,H	61798711(+)	`GTGTGT/CGCCCA`	2	C/C	syn¹ ese³		3		EA	1664
	rs1291205^1,2	A,C,F	61799273(+)	`GACACG/CCTGTG`	2	T/T	syn¹ ese³		2		EA MN	1662
	rs2258056^1,2	A,C,F	61798897(+)	`AACCGT/CGCCTG`	2	R/R	syn¹ spl³ ese³		3		EA NA	62
	rs909341^1,2	A,C	61799186(+)	`AGCAGC/TTCCAG`	2	S/S	syn¹ ese³		0	--	--	--	--
	rs2738787^1,2	C	61798819(+)	`TACCTA/GGAGCG`	2	L/L	syn¹		0	--	--	--	--
	rs1291206^1,2	C,F,H,O	61799613(+)	`CACGGG/AGAAAC`	2	--	int¹		6		MN EA EU WA	1340
--	rs1291207^1,2	A,C	61799856(+)	`TGGCCA/GCTCCT`	2	--	int¹		0	--	--	--	--
	rs6062496^1,2	A,H	61799543(+)	`CCTGGG/AGAGCT`	2	--	int¹		2		EA	178
	rs8114953^1,2	H	61799788(+)	`CCTTCC/TGATGG`	2	--	int¹		1		WA	120
--	rs61760055^1,2	--	61798649(+)	`TACGCA/GGAGTG`	2	G/R	mis¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for TNFRSF6B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603361

10/23 Novoseek disease relationships for TNFRSF6B gene (see all 23 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	55.36	35	15475369 (2), 10318773 (2), 12662434 (1), 18723214 (1) (see all 25)
tumors	49.92	94	12740925 (6), 10655513 (5), 12899749 (4), 15475369 (4) (see all 41)
colon adenocarcinoma	44.12	3	14871535 (1), 10318773 (1), 10655513 (1)
herpes	42.01	6	12566458 (1), 15917993 (1), 17010447 (1), 10318773 (1)
pancreatic cancer	35.05	11	12794752 (3), 19050262 (2), 11172597 (1), 18349319 (1) (see all 5)
hepatocellular carcinoma	30.68	15	12899749 (2), 17493386 (2), 16273601 (2), 12740925 (1) (see all 5)
gastric carcinoma	27.61	5	14728836 (2), 12740925 (1), 18991242 (1)
pancreatic carcinoma	24.62	2	12740925 (1)
malignant glioma	23.14	4	11289159 (4)
cancer	23.12	29	12899749 (2), 15661928 (2), 18349319 (2), 12397645 (1) (see all 15)

About this table

Human Genome Epidemiology Navigator: TNFRSF6B (8 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/99 PubMed articles for TNFRSF6B gene (see all 99 ):

A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. (PubMed id 10318773)^{1, 2, 3, 4} Yu K.Y....Kwon B.S. (1999)
Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. (PubMed id 9872321)^{1, 2, 3, 4} Pitti R.M.... Ashkenazi A. (1998)
Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. (PubMed id 10655513)^{1, 3, 4} Bai C....Caskey C.T. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
High DcR3 expression predicts stage pN2-3 in gastric cancer. (PubMed id 18376232)^{1, 3} Wu Y....Xie Q. (2008)
High DcR3 expression predicts stage pN2 in gastric cancer. (PubMed id 18251184)^{1, 3} Wu Y....Chen J. (2007)
Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma. (PubMed id 12794752)^{1, 3} Tsuji S....Imamura M. (2003)
Decoy receptor 3 is a prognostic factor in renal cell cancer. (PubMed id 18813347)^{1, 3} Macher-Goeppinger S....Roth W. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8771	HGNC: 11921	AceView: TNFRSF6B	Ensembl:ENSG00000026036	euGenes: HUgn8771
ECgene: TNFRSF6B	H-InvDB: TNFRSF6B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TNFRSF6B	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TNFRSF6B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TNFRSF6B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TNFRSF6B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TNFRSF6B		Antibodies for TNFRSF6B
	Explore super-pooled esiRNAs		Proteins for TNFRSF6B
	Lentivirus-delivered shRNAs for TNFRSF6B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TNFRSF6B)
	Antibodies (TNFRSF6B)
	Chimera RNAi (TNFRSF6B)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for TNFRSF6B (dcr3)

	Recombinant Proteins (DcR3)
	Antibodies (DcR3)

Search OriGene for TNFRSF6B

Search Tocris compounds for TNFRSF6B

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TNFRSF6B

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TNFRSF6B Gene at Home site.
Version 2.41.1
server5.xennexinc.com

TNFRSF6B Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for TNFRSF6B

Summaries
for TNFRSF6B

Genomic Location
for TNFRSF6B

Proteins
for TNFRSF6B

Protein Domains/
Families
for TNFRSF6B

Gene Function
for TNFRSF6B

Pathways & Interactions
for TNFRSF6B

Drugs & Compounds
for TNFRSF6B

Transcripts
for TNFRSF6B

Expression
for TNFRSF6B

Orthologs
for TNFRSF6B

Paralogs
for TNFRSF6B

SNPs/Variants
for TNFRSF6B

Disorders & Mutations
for TNFRSF6B

Medical News
for TNFRSF6B

Publications
for TNFRSF6B

Search for TNFRSF6B

Genome Databases showing TNFRSF6B

Other Databases showing TNFRSF6B

Specialized Databases showing TNFRSF6B

Licensable Technologies
for TNFRSF6B

Services
for TNFRSF6B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TNFRSF6B Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor TNFRSF6B

Summariesfor TNFRSF6B

Genomic Locationfor TNFRSF6B

Proteinsfor TNFRSF6B

Protein Domains/Familiesfor TNFRSF6B

Gene Functionfor TNFRSF6B

Pathways & Interactionsfor TNFRSF6B

Drugs & Compoundsfor TNFRSF6B

Transcriptsfor TNFRSF6B

Expression for TNFRSF6B

Orthologsfor TNFRSF6B

Paralogsfor TNFRSF6B

SNPs/Variantsfor TNFRSF6B

Disorders & Mutationsfor TNFRSF6B

Medical Newsfor TNFRSF6B

Publicationsfor TNFRSF6B

Search for TNFRSF6B

Genome Databases showing TNFRSF6B

Other Databases showing TNFRSF6B

Specialized Databases showing TNFRSF6B

Licensable Technologiesfor TNFRSF6B

Servicesfor TNFRSF6B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TNFRSF6B

Summaries
for TNFRSF6B

Genomic Location
for TNFRSF6B

Proteins
for TNFRSF6B

Protein Domains/
Families
for TNFRSF6B

Gene Function
for TNFRSF6B

Pathways & Interactions
for TNFRSF6B

Drugs & Compounds
for TNFRSF6B

Transcripts
for TNFRSF6B

Expression
for TNFRSF6B

Orthologs
for TNFRSF6B

Paralogs
for TNFRSF6B

SNPs/Variants
for TNFRSF6B

Disorders & Mutations
for TNFRSF6B

Medical News
for TNFRSF6B

Publications
for TNFRSF6B

Licensable Technologies
for TNFRSF6B

Services
for TNFRSF6B