Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TNFRSF6B Gene

protein-coding   GIFtS: 61
GCID: GC20P062326

Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy

  See TNFRSF6B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy1 2     TR62 3
DCR32 3 5     DJ583P15.1.12
Decoy Receptor 32 3     M68E2
Decoy Receptor For Fas Ligand2 3     Tumor Necrosis Factor Receptor Superfamily Member 6B2
M682 3     DcR33

External Ids:    HGNC: 119211   Entrez Gene: 87712   Ensembl: ENSG000002435097   OMIM: 6033615   UniProtKB: O954073   

Export aliases for TNFRSF6B gene to outside databases

Previous GC identifers: GC20P062166 GC20U900077 GC20P063052 GC20P063016 GC20P061761 GC20P059059


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TNFRSF6B Gene:
This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a
regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes
with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract
tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of
telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. (provided by RefSeq, Feb 2011)

GeneCards Summary for TNFRSF6B Gene:
TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b, decoy) is a protein-coding gene. Diseases associated with TNFRSF6B include colon adenocarcinoma, and crescentic glomerulonephritis. GO annotations related to this gene include receptor activity. An important paralog of this gene is TNFRSF21.

UniProtKB/Swiss-Prot: TNF6B_HUMAN, O95407
Function: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects
against apoptosis

Gene Wiki entry for TNFRSF6B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNFRSF6B gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TNFRSF6B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF6B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.3   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

TNFRSF6B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF6B gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P062326:  view genomic region     (about GC identifiers)

Start:
62,328,004 bp from pter      End:
62,330,051 bp from pter
Size:
2,048 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TNF6B_HUMAN, O95407 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 6B precursor  
Size: 300 amino acids; 32680 Da
Selected PDB 3D structures from and Proteopedia for TNFRSF6B (see all 7):
3K51 (3D)        3MHD (3D)        3MI8 (3D)        4J6G (3D)        4KGG (3D)        4KGQ (3D)    

Explore the universe of human proteins at neXtProt for TNFRSF6B: NX_O95407

Explore proteomics data for TNFRSF6B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn173

  • See TNFRSF6B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003814.1  
    ENSEMBL proteins: 
     ENSP00000359013  

    TNFRSF6B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TNFRSF6B (DcR3/TNFRSF6B)
    Enzo Life Sciences proteins for TNFRSF6B
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TNFRSF6B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TNFRSF6B
    GenScript Custom Purified and Recombinant Proteins Services for TNFRSF6B
    Novus Biologicals TNFRSF6B Proteins
    Novus Biologicals TNFRSF6B Lysates
    Sino Biological Recombinant Protein for TNFRSF6B
    Sino Biological Cell Lysate for TNFRSF6B
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNFRSF6B

     
    Search eBioscience for Proteins for TNFRSF6B 

    TNFRSF6B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TNFRSF6B (DcR3/TNFRSF6B)
    Cell Signaling Technology (CST) Antibodies for TNFRSF6B 
    OriGene Antibodies for TNFRSF6B
    OriGene Custom Antibody Services for TNFRSF6B
    Novus Biologicals TNFRSF6B Antibodies
    Abcam antibodies for TNFRSF6B
    Cloud-Clone Corp. Antibodies for TNFRSF6B
    ThermoFisher Antibody for TNFRSF6B
    LSBio Antibodies in human, mouse, rat for TNFRSF6B

    TNFRSF6B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TNFRSF6B
    R&D Systems ELISAs for TNFRSF6B (DcR3/TNFRSF6B)         (see all)
    GenScript Custom Assay Services for TNFRSF6B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TNFRSF6B
    Cloud-Clone Corp. CLIAs for TNFRSF6B
    Search eBioscience for ELISAs for TNFRSF6B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: decoy receptor 3
    Tumour necrosis factor (TNF) receptor family

    1 InterPro protein domain:
     IPR001368 TNFR/NGFR_Cys_rich_reg

    Graphical View of Domain Structure for InterPro Entry O95407

    ProtoNet protein and cluster: O95407

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: TNF6B_HUMAN, O95407
    Similarity: Contains 4 TNFR-Cys repeats


    Find genes that share domains with TNFRSF6B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNF6B_HUMAN, O95407
    Function: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects
    against apoptosis

         Genatlas biochemistry entry for TNFRSF6B:
    tumor necrosis factor receptor superfamily,member 6B,binding Fas ligand (TNFRSF6) and inhibiting FasL induced
    apoptosis,amplified in primary lung and colon tumors

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9872321
    GO:0005515protein binding IPI10318773
         
    Find genes that share ontologies with TNFRSF6B           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFRSF6B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNFRSF6B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNFRSF6B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNFRSF6B

    miRNA
    Products:
        
    miRTarBase miRNAs that target TNFRSF6B:
    hsa-mir-34a-5p (MIRT004905)

    Block miRNA regulation of human, mouse, rat TNFRSF6B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TNFRSF6B
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TNFRSF6B
    Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF6B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TNFRSF6B

    Clone
    Products:
         
    OriGene clones in human, mouse for TNFRSF6B (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNFRSF6B (NM_003823)
    Sino Biological Human cDNA Clone for TNFRSF6B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF6B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF6B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TNFRSF6B
    Browse ESI BIO Cell Lines and PureStem Progenitors for TNFRSF6B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF6B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TNF6B_HUMAN, O95407: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space NAS10318773

    Find genes that share ontologies with TNFRSF6B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TNFRSF6B About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2TWEAK Pathway
    Apoptosis through Death Receptors0.42
    Fas Signaling0.35
    3ERK Signaling
    Molecular Mechanisms of Cancer0.51
    4Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    5PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43


    Find genes that share SuperPaths with TNFRSF6B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TNFRSF6B
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TNFRSF6B
        Apoptosis through Death Receptors
    Molecular Mechanisms of Cancer
    Fas Signaling

    1 Cell Signaling Technology (CST) Pathway for TNFRSF6B
        Apoptosis and Autophagy

    1 GeneGo (Thomson Reuters) Pathway for TNFRSF6B
        Apoptosis and survival FAS signaling cascades

    1 BioSystems Pathway for TNFRSF6B
        Apoptosis Modulation and Signaling

    3 Sino Biological Pathways for TNFRSF6B
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1 Kegg Pathway  (Kegg details for TNFRSF6B):
        Cytokine-cytokine receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF6B: 
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TNFRSF6B

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TNFRSF6B (O954071, 3 ENSP000003590134) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFSF14O435571, 3, ENSP000002459124EBI-524171,EBI-524131 I2D: score=2 STRING: ENSP00000245912
    TNFSF15O951503, ENSP000003631574I2D: score=1 STRING: ENSP00000363157
    FASLGP480233, ENSP000003566944I2D: score=1 STRING: ENSP00000356694
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0043066negative regulation of apoptotic process TAS9872321

    Find genes that share ontologies with TNFRSF6B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNFRSF6B (TNF6B)

    1 Novoseek inferred chemical compound relationship for TNFRSF6B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 11.3 3 14688085 (1), 19050262 (1), 14697332 (1)



    Find genes that share compounds with TNFRSF6B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TNFRSF6B gene (2 alternative transcripts): 
    NM_003823.3  NM_032945.2  

    Unigene Cluster for TNFRSF6B:

    Tumor necrosis factor receptor superfamily, member 6b, decoy
    Hs.434878  [show with all ESTs]
    Unigene Representative Sequence: BQ688727
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369996
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TNFRSF6B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TNFRSF6B
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TNFRSF6B
    Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF6B
    Clone
    Products:
         
    OriGene clones in human, mouse for TNFRSF6B (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNFRSF6B (NM_003823)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNFRSF6B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF6B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TNFRSF6B
    OriGene qSTAR qPCR primer pairs in human, mouse for TNFRSF6B
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TNFRSF6B
      QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF6B
      QuantiFast Probe-based Assays in human, mouse, rat TNFRSF6B

    Additional mRNA sequence: 

    AF104419.1 AF134240.1 AF217794.1 AY124378.1 AY124379.1 AY358279.1 BC017065.1 BC034349.1 

    6 DOTS entries:

    DT.101980777  DT.100026806  DT.97770485  DT.99984254  DT.100746777  DT.100746778 

    Selected AceView cDNA sequences (see all 190):

    BF987793 BE877829 NM_032957 BM784338 AU099288 BE467871 AI857725 BM742134 
    AW955349 NM_016434 AF217795 AI304479 AW135723 AI380034 AY124378 BM784181 
    AF104419 BM756086 BU623385 AY358279 BM857412 NM_003823 AA326540 BF001490 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TNFRSF6B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACCCTGTG
    TNFRSF6B Expression
    About this image

    TNFRSF6B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNFRSF6B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434878

    UniProtKB/Swiss-Prot: TNF6B_HUMAN, O95407
    Tissue specificity: Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node,
    trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum,
    esophagus and in SW480 colon carcinoma cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TNFRSF6B: 
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TNFRSF6B
    OriGene qSTAR qPCR primer pairs in human, mouse for TNFRSF6B
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TNFRSF6B
    QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF6B
    QuantiFast Probe-based Assays in human, mouse, rat TNFRSF6B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF6B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TNFRSF6B gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia TNFRSF6B1 tumor necrosis factor receptor superfamily, member more 82.57(n)
    79.39(a)
      102152544  XM_005635296.1  XP_005635353.1 
    chicken
    (Gallus gallus)
    Aves TNFRSF6B1 tumor necrosis factor receptor superfamily, member more 63.52(n)
    54.34(a)
      395096  XM_417434.4  XP_417434.2 
    lizard
    (Anolis carolinensis)
    Reptilia TNFRSF6B6
    tumor necrosis factor receptor superfamily, member...
    54(a)
    1 ↔ 1
    GL343401.1(874091-882568)
    zebrafish
    (Danio rerio)
    Actinopterygii tnfrsf11b6
    tumor necrosis factor receptor superfamily, member...
    25(a)
    1 → many
    19(157731-161607) ENSDARG00000034243


    ENSEMBL Gene Tree for TNFRSF6B (if available)
    TreeFam Gene Tree for TNFRSF6B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TNFRSF6B gene
    TNFRSF212  TNFRSF11A2  LTBR2  TNFRSF11B2  TNFRSF142  CD402  TNFRSF1B2  
    2 SIMAP similar genes for TNFRSF6B using alignment to 4 protein entries:     TNF6B_HUMAN (see all proteins):
    TNFRSF11B    TNFRSF1B

    Find genes that share paralogs with TNFRSF6B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TNFRSF6B (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv913250CNV Loss21882294
    dgv4647n71CNV Loss21882294
    dgv4644n71CNV Loss21882294
    nsv470563CNV Loss18288195
    dgv4645n71CNV Loss21882294
    nsv913213CNV Loss21882294
    nsv913190CNV Loss21882294
    dgv4618n71CNV Loss21882294
    nsv913241CNV Loss21882294
    nsv913249CNV Loss21882294

    Human Gene Mutation Database (HGMD): TNFRSF6B
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing TNFRSF6B:
    Lung Cancer
    SeqTarget long-range PCR primers for resequencing TNFRSF6B
    DNA2.0 Custom Variant and Variant Library Synthesis for TNFRSF6B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603361    OMIM disorders: --

    9 diseases for TNFRSF6B:    
    About MalaCards
    colon adenocarcinoma    crescentic glomerulonephritis    oral cavity cancer    malignant glioma
    autoimmune hepatitis    silicosis    esophageal squamous cell carcinoma    pancreatic cancer
    hepatocellular carcinoma


    Find genes that share disorders with TNFRSF6B           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TNFRSF6B gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 56.7 47 15475369 (2), 10318773 (2), 12662434 (1), 18723214 (1) (see all 31)
    tumors 49.8 108 12740925 (6), 10655513 (5), 12899749 (4), 15475369 (4) (see all 48)
    herpes 44.6 6 12566458 (1), 15917993 (1), 17010447 (1), 10318773 (1)
    pancreatic carcinoma 41.2 2 12740925 (1)
    colon adenocarcinoma 40.8 3 14871535 (1), 10318773 (1), 10655513 (1)
    pancreatic cancer 36 12 12794752 (3), 19050262 (2), 11172597 (1), 19466993 (1) (see all 6)
    hepatocellular carcinoma 34 18 12899749 (2), 17493386 (2), 16273601 (2), 19195939 (2) (see all 7)
    cancer 29.9 33 12899749 (2), 15661928 (2), 18349319 (2), 12397645 (1) (see all 19)
    gastric carcinoma 23.8 5 14728836 (2), 12740925 (1), 18991242 (1)
    rheumatoid arthritis 22.6 6 19821006 (2), 18757243 (1), 17393415 (1)

    Genetic Association Database (GAD): TNFRSF6B
    Human Genome Epidemiology (HuGE) Navigator: TNFRSF6B (16 documents)

    Export disorders for TNFRSF6B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TNFRSF6B gene, integrated from 10 sources (see all 158):
    (articles sorted by number of sources associating them with TNFRSF6B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. (PubMed id 10318773)1, 2, 3, 9 Yu K.-Y.... Kwon B.S. (J. Biol. Chem. 1999)
    2. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. (PubMed id 9872321)1, 2, 3, 9 Pitti R.M.... Ashkenazi A. (Nature 1998)
    3. Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. (PubMed id 10655513)1, 2, 9 Bai C.... Caskey C.T. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    4. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. (PubMed id 18758464)1, 4, 9 Kugathasan S....Hakonarson H. (Nat. Genet. 2008)
    5. Decoy strategies: the structure of TL1A:DcR3 complex. (PubMed id 21300286)1, 2 Zhan C.... Almo S.C. (Structure 2011)
    6. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
    7. Polymorphisms of decoy receptor 3 are associated with risk of esophageal squamous cell carcinoma in Chinese Han. (PubMed id 20567955)1, 4 Xiong G....Bai Y. (Tumour Biol. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Evidence of epistasis between TNFRSF14 and TNFRSF6B polymorphisms in patients with rheumatoid arthritis. (PubMed id 20187130)1, 4 Perdigones N....Urcelay E. (Arthritis Rheum. 2010)
    10. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8771 HGNC: 11921 AceView: TNFRSF6B Ensembl:ENSG00000243509 euGenes: HUgn8771
    ECgene: TNFRSF6B Kegg: 8771 H-InvDB: TNFRSF6B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TNFRSF6B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNFRSF6B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TNFRSF6B gene:
    Search GeneIP for patents involving TNFRSF6B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for TNFRSF6B (DcR3/TNFRSF6B)   Browse Cell Culture Products  
     ELISAs for TNFRSF6B (DcR3/TNFRSF6B)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Luminex Assays for TNFRSF6B (DcR3/TNFRSF6B)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for TNFRSF6B (DcR3/TNFRSF6B)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TNFRSF6B   OriGene RNAi products in human, mouse, rat for TNFRSF6B  
     OriGene qPCR primer pairs and template standards for TNFRSF6B   OriGene Protein Over-expression Lysate for TNFRSF6B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TNFRSF6B  
     OriGene qSTAR qPCR primer pairs in human, mouse for TNFRSF6B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TNFRSF6B   OriGene Custom Protein Services for TNFRSF6B  

     
     
     Block miRNA regulation of human, mouse, rat TNFRSF6B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TNFRSF6B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNFRSF6B Predesigned siRNA for gene silencing in human, mouse, rat TNFRSF6B
     QuantiFast Probe-based Assays in human, mouse, rat TNFRSF6B QuantiTect SYBR Green Assays in human, mouse, rat TNFRSF6B
     PCR Arrays including human, mouse / rat TNFRSF6B Search Chromatin IP Primers for TNFRSF6B
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TNFRSF6B  GeneGlobe Interaction Network for TNFRSF6B
     Regulatory tfbs in TNFRSF6B promoter
     GenScript Custom Purified and Recombinant Proteins Services for TNFRSF6B GenScript cDNA clones with any tag delivered in your preferred vector for TNFRSF6B
     GenScript Custom Assay Services for TNFRSF6B GenScript Custom overexpressing Cell Line Services for TNFRSF6B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for TNFRSF6B 

     Search Tocris compounds for TNFRSF6B (TNF6B)
     Proteins for TNFRSF6B
     Cell Lysates for TNFRSF6B
     cDNA Clones for TNFRSF6B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for TNFRSF6B
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TNFRSF6B antibodies
     TNFRSF6B proteins
     TNFRSF6B lysates
     Antibodies for TNFRSF6B
     See all of Abcam's Antibodies, Kits and Proteins for TNFRSF6B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TNFRSF6B
     Antibodies for TNFRSF6B
     ELISAs for TNFRSF6B
     CLIAs for TNFRSF6B



     Browse ESI BIO Cell Lines and PureStem Progenitors for TNFRSF6B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNFRSF6B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TNFRSF6B
     Browse SwitchGear Promoter luciferase reporter plasmids for TNFRSF6B
     ThermoFisher Antibody for TNFRSF6B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNFRSF6B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNFRSF6B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TNFRSF6B
     LSBio Antibodies in human, mouse, rat for TNFRSF6B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for TNFRSF6B
      Search eBioscience for proteins for TNFRSF6B
      Search eBioscience for elisas for TNFRSF6B
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TNFRSF6B gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4