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CD40 Gene

protein-coding GIFtS: 66

GC20P044181

CD40 molecule, TNF receptor superfamily member 5
(Previous names: tumor necrosis factor receptor superfamily, member 5 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TNFRSF5)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Bp50 ^¹, ², ³
CDW40 ^²
CDw40 ^³
MGC9013 ^²
OTTHUMP00000031699 ^²
OTTHUMP00000031700 ^²
TNFRSF5 ^², ³, ⁵
p50 ^¹, ²

Descriptions
B cell surface antigen CD40 ^²
B cell-associated molecule ^²
B-cell surface antigen CD40 ^³
CD40 antigen ^², ³
CD40 antigen (TNF receptor superfamily member 5) ^²
CD40 molecule, TNF receptor superfamily member 5 ^²
CD40 type II isoform ^²
CD40L receptor ^², ³
nerve growth factor receptor-related B-lymphocyte activation molecule ^²
tumor necrosis factor receptor superfamily, member 5 ^¹, ²

External Ids
HGNC: 11919¹
Entrez Gene: 958²
UniProtKB: P25942³
Ensembl: ENSG00000101017⁷

Search outside databases for aliases for CD40 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CD40:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has

been found to be essential in mediating a broad variety of immune and inflammatory responses

including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal

center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the

expression of this receptor and its ligand, which may be important for homotypic cell

interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the

signal transduction. The interaction of this receptor and its ligand is found to be necessary for

amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer

disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct

isoforms have been reported. [provided by RefSeq]

UniProtKB/Swiss-Prot: TNR5_HUMAN, P25942

Function: Receptor for TNFSF5/CD40LG

Gene Wiki entry for CD40

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CD40 gene

Entrez Gene cytogenetic band: 20q12-q13.2 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q12-q13.2

CD40 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P044181: (about GC identifiers)

Start:	44,180,313 bp from pter
End:	44,195,894 bp from pter
Size:	15,582 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TNR5_HUMAN, P25942 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 5 precursor

Size: 277 amino acids; 30619 Da

Subunit: Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549

does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6

Subcellular location: Isoform I: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform II: Secreted

PDB structures from and Proteopedia :

1CDF (3D)

1CZZ (3D)

1D00 (3D)

1FLL (3D)

1LB6 (3D)

Secondary accessions: Q53GN5 Q5JY15 Q5U007 Q7M4Q8 Q86YK5 Q9BYU0

Alternative splicing: 2 isoforms: P25942-1 P25942-2 (Additional isoforms seem to exist)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001241.1 NP_690593.1

ENSEMBL proteins:

ENSP00000279061 ENSP00000361359 ENSP00000361350 ENSP00000361352

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for CD40 (CD40/TNFRSF5)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CD40)
	Human Recombinant Proteins from Abnova (CD40)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	TAS	10748139
GO:0005887	integral to plasma membrane	TAS	10748139

About this table

Antibodies for CD40:

	Invitrogen Antibodies for CD40
	Millipore Mono- and Polyclonal Antibodies for the study of CD40
	Sigma-Aldrich Antibody Arrays and Antibodies for CD40
	R&D Systems Antibodies for CD40 (CD40/TNFRSF5)
	Antibodies from Abcam (CD40), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CD40)
	Novus Biologicals Antibodies for CD40

Assays for CD40:

	Invitrogen Assays for CD40
	Millipore Kits and Assays for the Analysis of CD40
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P25942

ProtoNet protein and cluster: P25942

2 Blocks protein families:

IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

IPB008063 FAS/CD95 receptor family signature

UniProtKB/Swiss-Prot: TNR5_HUMAN, P25942

Similarity: Contains 4 TNFR-Cys repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CD40)
		Millipore RNAi Products for the Analysis of CD40 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CD40)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001250

Applied Biosystems Silencer® siRNAs for CD40

Sigma-Aldrich siRNA and siRNA Panels for CD40

Sigma-Aldrich shRNA Panels and shRNA for CD40

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CD40
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001250
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001250
untagged cDNA clones in CMV expression vector (see all 2): NM_001250

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001250

UniProtKB/Swiss-Prot: TNR5_HUMAN, P25942

Function: Receptor for TNFSF5/CD40LG

4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cd40):

hematopoietic system

homeostasis/metabolism

immune system

renal/urinary system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane receptor activity	IEA	--
GO:0019899	enzyme binding	IPI	12223522

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/12 Sigma-Aldrich "Your Favorite Gene" Pathways for CD40 (Your Favorite Gene powered by Ingenuity) (see all 12 )

IL-12 Signaling and Production in Macrophages
Primary Immunodeficiency Signaling
TREM1 Signaling
Autoimmune Thyroid Disease Signaling
Hepatic Fibrosis / Hepatic Stellate Cell Activation

GeneDecks CD40 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CD40

5/216 Interacting proteins for CD40 (P25942¹ ENSP00000279061³) via UniProtKB, MINT, and/or STRING (see all 216 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRAF3	Q13114¹, ENSP00000332468³	EBI-525714, EBI-357631 STRING (score=.999)
TRAF6	Q9Y4K3¹, ENSP00000337853³	EBI-525714, EBI-359276 STRING (score=.999)
TRAF2	Q5T1L5¹, ENSP00000352685³	EBI-525714, EBI-1046651 STRING (score=.917)
HLA-C	ENSP00000365412³	STRING (score=.702) STRING (score=.722)
CALR	P27797¹	EBI-525714, EBI-1049597

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006461	protein complex assembly	TAS	10748139
GO:0006915	apoptosis	IEA	--
GO:0006954	inflammatory response	TAS	2475341
GO:0006955	immune response	IEA	--
GO:0007165	signal transduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CD40
10/53 Novoseek chemical compound relationships for CD40 gene (see all 53 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lfa703	70.42	4	15618295 (3), 17482516 (1)
rantes	60.35	35	16864989 (8), 11274230 (5), 12122011 (3), 11754818 (1) (see all 17)
blys	53.73	8	17567982 (2), 11015437 (1), 12154359 (1), 16644731 (1) (see all 5)
ionomycin	49.89	9	1708162 (1), 16223731 (1), 9727564 (1), 7699321 (1) (see all 9)
triazolopyrimidine	46.50	7	10600333 (5)
pd 98,059	34.11	5	16272352 (1), 16904975 (1), 19288477 (1), 10586056 (1)
cytidine	31.42	7	14752331 (1), 14978013 (1), 17154264 (1), 17485519 (1) (see all 5)
mevalonate	28.03	1	12426205 (1)
bcma	26.30	2	12865416 (1), 15708970 (1)
tyrosine	23.99	32	12437073 (3), 7523475 (2), 8816388 (2), 9133417 (2) (see all 20)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CD40)
		Millipore RNAi Products for the Analysis of CD40 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CD40)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001250

Sigma-Aldrich siRNA and siRNA Panels for CD40

Sigma-Aldrich shRNA Panels and shRNA for CD40

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001250 NM_152854

REFSEQ mRNAs for CD40 gene (2 alternative transcripts):

NM_001250.4 NM_152854.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001250 NM_152854

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001250
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001250
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001250

Additional cDNA sequence:

AB209660.1 AJ300189.1 AK222896.1 AY225405.1 BC012419.1 BC064518.1 BT019901.1 CR605787.1

CR608994.1 CR619622.1

9 DOTS entries:

DT.451574 DT.100791759 DT.86853137 DT.100791764 DT.95170181 DT.92423397 DT.102104 DT.40204598

DT.95170183

24/119 AceView cDNA sequences (see all 119 ):

CA417566 BQ548631 AI674469 AI733071 H50599 AI356484 BM456032 AI267899

AA767182 AA749024 AA913214 AA886208 BC012419 BM707407 CR605787 BM708033

AA934395 BI759406 NM_152854 AA876065 CA944736 CR608994 BM477258 AI791563

highest scoring ESTs for CD40:

AA147464 AA706580 AA749024 AI457714 AI865431 BC012419 BC064518 BE879861 BF869012 BI759406

Unigene Cluster for CD40:

CD40 molecule, TNF receptor superfamily member 5

Hs.472860 [show with all ESTs]

Unigene Representative Sequence: AB209660

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CD40

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	^	8
SP1:					-												-				-
SP2:					-								-		-						-
SP3:													-				-				-
SP4:																	-

About this scheme

ECgene alternative splicing isoforms for CD40

4 Ensembl transcripts including schematic representations:

ENST00000279061 ENST00000372285 ENST00000372276 ENST00000372278

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CD40 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CD40

¹ / ² / ³

10 probe-sets matching CD40 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35150_at²^{, 3}	U133-A	1	1.00	1.00	0.88	1.17	X60592	0.80	1.00	0.91	1
35149_at²^{, 3}	U95-A	1	0.75	1.00	0.99	0.84	AI865431	0.80	1.00	0.91	1
205153_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001250	0.60	1.00	0.82	1
35150_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X60592	0.80	1.00	0.91	1
222292_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW298127	0.40	1.00	0.76	1
215346_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF664114	0.40	1.00	0.76	1
205153_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
35150_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222292_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215346_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CD40 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.472860
Expression variation in blood from EXPOLDB for CD40
UniProtKB/Swiss-Prot: TNR5_HUMAN, P25942
Tissue specificity: B-cells and in primary carcinomas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CD40 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CD40¹	--	CD40 molecule, TNF receptor superfamily member 5	79.34(n) 71.59(a)	403469 NM_001002982.1 NP_001002982.1
cow (Bos taurus)	CD40¹	--	CD40 molecule, TNF receptor superfamily member 5	76.77(n) 68.23(a)	286849 XM_581509.3 XP_581509.2
rat (Rattus norvegicus)	Cd40¹	--	CD40 molecule, TNF receptor superfamily member 5	70.56(n) 60.58(a)	171369 NM_134360.1 NP_599187.1
mouse (Mus musculus)	Cd40^{1, 5}	2 (97.00 cM)⁵	CD40 antigen^{1, 5}	71.29(n)¹ 62.77(a)¹	21939¹ NM_011611.2¹ NP_035741.2¹ AI326936⁵ AI385482⁵ (see all 30)
chicken (Gallus gallus)	CD40¹	--	CD40 molecule, TNF receptor superfamily member 5	52.58(n) 42.64(a)	395385 NM_204665.1 NP_989996.1

About this table Species with no ortholog for CD40

ENSEMBL Gene Tree for CD40

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CD40 gene

TNFRSF11A² NGFR² LTBR² TNFRSF4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/141 NCBI SNPs in CD40 are shown (see all 141 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 99)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs752118^1,2	A,C,F,H,O	44180145(+)	`TGGGAC/TCATGC`	2	--	ng5¹		22	NS NA MN EA EU WA	2116
	rs1800686^1,2	A,C,F,H,O	44179810(+)	`CACACG/AAGGGA`	2	--	ng5¹ tfbs³		12	EA NA EU WA	764
	rs1883832^1,2	A,C,F,H,O	44180389(+)	`CTCGCC/TATGGT`	2	--	ut5¹		11	EU EA WA NS NA MN	1142
	rs11569343^1,2	C,F,H	44191221(+)	`GCACCC/GCTGCA`	2	--	ut3¹ ese³		9	NS EU EA WA	1014
	rs7273698^1,2	C,F,H	44190230(+)	`ATCTTC/TGGGAT`	2	R/W F/F	mis¹ syn¹		10	NS EU EA WA NA	1062
	rs11569321^1,2	C,F,H	44184770(+)	`CCGCTC/TATGCT`	2	S/L	mis¹ ese³		10	NS EU EA WA NA	1046
--	rs11569300^1,2	C,F	44180321(+)	`AAGGCT/-GGGGC`	2	--	ut5¹		2	NS NA	214
	rs11086998^1,2	C,F	44190931(+)	`AGGCCC/GCCCAC`	2	P/A	mis¹ ut3¹ ese³		7	NS	634
	rs11569345^1,2	F,H	44191928(+)	`TGCTGG/AGTGAC`	2	--	ng3¹		5	NS EU EA WA	580
	rs11569301^1,2	F,H	44180349(+)	`CCTCGC/TTCGGG`	2	--	ut5¹ ese³		5	NS EU EA WA	598

About this table

HapMap Linkage Disequilibrium images for CD40 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 109535 disorders: 606843

UniProtKB/Swiss-Prot: TNR5_HUMAN, P25942

Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3) [MIM:606843].

HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype

switching, one of the final differentiation steps in the humoral immune system, an inability to

mount an antibody-specific immune response, and a lack of germinal center formation

10/93 Novoseek disease relationships for CD40 gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hyper-igm syndrome	80.16	23	9058789 (3), 14752331 (2), 11358428 (2), 10559240 (1) (see all 14)
higm3	77.77	3	15661021 (1), 14610488 (1), 12893749 (1)
necrosis	74.41	233	9511754 (3), 14517219 (2), 10096561 (2), 10318845 (2) (see all 99)
tumors	60.87	333	8623911 (6), 11304696 (6), 10980464 (5), 10473114 (4) (see all 99)
m syndrome	60.16	2	15661021 (1), 8914765 (1)
inflammation	54.41	62	11488834 (2), 19183933 (2), 12209092 (2), 12759449 (2) (see all 47)
atherosclerosis	45.89	18	17967972 (2), 15921025 (1), 16904975 (1), 15280513 (1) (see all 16)
autoimmune diseases	45.33	13	9617563 (1), 17114447 (1), 12223069 (1), 11905840 (1) (see all 10)
latent virus infection	43.99	1	11278268 (1)
atherosclerotic plaque	42.48	9	10049948 (2), 9244201 (2), 10623647 (1), 16356505 (1) (see all 7)

About this table

Human Gene Mutation Database: CD40
Genetic Association Database: CD40
Human Genome Epidemiology Navigator: CD40 (42 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1321 PubMed articles for CD40 gene (see all 1321 ):

CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. (PubMed id 9718306)^{1, 3, 4} Pullen S.S....Kehry M.R. (1998)
Regulation of CD40 function by its isoforms generated through alternative splicing. (PubMed id 11172023)^{1, 3, 4} Tone M.... Waldmann H. (2001)
Downstream regulator TANK binds to the CD40 recognition site on TRAF3. (PubMed id 12005438)^{1, 3, 4} Li C.... Ely K.R. (2002)
Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells. (PubMed id 11676606)^{1, 3, 4} Khandekar S.S....Fishman-Lobell J. (2001)
Molecular basis for CD40 signaling mediated by TRAF3. (PubMed id 10984535)^{1, 3, 4} Ni C.Z.... Ely K.R. (2000)
The role of polar interactions in the molecular recognition of CD40L with its receptor CD40. (PubMed id 9605317)^{1, 3, 4} Singh J.... Thomas D. (1998)
Association of CD40 gene polymorphism (C-1T) with susceptibility and phenotype of Graves' disease. (PubMed id 16279844)^{1, 3, 6} Kurylowicz A....Bednarczuk T. (2005)
Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). (PubMed id 9511754)^{1, 3, 4} Mizushima S.... Inoue J. (1998)
A C/T polymorphism in the 5' untranslated region of the CD40 gene is associated with later onset of Graves' disease in Japanese. (PubMed id 16127217)^{1, 3, 6} Mukai T....Yamada K. (2005)
Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. (PubMed id 11675497)^{1, 3, 4} Ferrari S....Plebani A. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 958	HGNC: 11919	AceView: TNFRSF5	Ensembl:ENSG00000101017	euGenes: HUgn958
ECgene: CD40	H-InvDB: CD40

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CD40	Genetics and Cytogenetics in Oncology and Haematology
CD40base	http://bioinf.uta.fi/CD40base/
GeneReviews	http://www.genetests.org/query?gene=CD40
NIEHS-SNPs	http://egp.gs.washington.edu/data/tnfrsf5/
Wikipedia	http://en.wikipedia.org/wiki/CD40

Licensable Technologies for CD40
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CD40:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CD40-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CD40		Antibodies for CD40
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CD40		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CD40)
	Antibodies (CD40)
	Chimera RNAi (CD40)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (CD40)
	Antibodies (CD40)

Search OriGene for CD40

Search Tocris compounds for CD40

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CD40

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CD40 Gene at Home site.
Version 2.41.1
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CD40 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CD40

Summaries
for CD40

Genomic Location
for CD40

Proteins
for CD40

Protein Domains/
Families
for CD40

Gene Function
for CD40

Pathways & Interactions
for CD40

Drugs & Compounds
for CD40

Transcripts
for CD40

Expression
for CD40

Orthologs
for CD40

Paralogs
for CD40

SNPs/Variants
for CD40

Disorders & Mutations
for CD40

Medical News
for CD40

Publications
for CD40

Search for CD40

Genome Databases showing CD40

Other Databases showing CD40

Specialized Databases showing CD40

Licensable Technologies
for CD40

Services
for CD40

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CD40 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CD40

Summariesfor CD40

Genomic Locationfor CD40

Proteinsfor CD40

Protein Domains/Familiesfor CD40

Gene Functionfor CD40

Pathways & Interactionsfor CD40

Drugs & Compoundsfor CD40

Transcriptsfor CD40

Expression for CD40

Orthologsfor CD40

Paralogsfor CD40

SNPs/Variantsfor CD40

Disorders & Mutationsfor CD40

Medical Newsfor CD40

Publicationsfor CD40

Search for CD40

Genome Databases showing CD40

Other Databases showing CD40

Specialized Databases showing CD40

Licensable Technologiesfor CD40

Servicesfor CD40

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CD40

Summaries
for CD40

Genomic Location
for CD40

Proteins
for CD40

Protein Domains/
Families
for CD40

Gene Function
for CD40

Pathways & Interactions
for CD40

Drugs & Compounds
for CD40

Transcripts
for CD40

Expression
for CD40

Orthologs
for CD40

Paralogs
for CD40

SNPs/Variants
for CD40

Disorders & Mutations
for CD40

Medical News
for CD40

Publications
for CD40

Licensable Technologies
for CD40

Services
for CD40